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T Cells with Chimeric Antigen Receptors Have Potent Antitumor Effects and Can Establish Memory in Patients
with Advanced Leukemia
by Michael Kalos, Bruce L. Levine, David L. Porter, Sharyn Katz, Stephan A. Grupp, Adam Bagg, and Carl H. June
Sci Transl MedVolume 3(95):95ra73-95ra73
August 10, 2011
Published by AAAS
Fig. 1 Schematic representation of the gene transfer vector and transgene, gene-modified T cell manufacturing, and clinical protocol design.
Michael Kalos et al., Sci Transl Med 2011;3:95ra73
Published by AAAS
Fig. 2 Sustained in vivo expansion and persistence in blood and marrow of CART19 cells.
Michael Kalos et al., Sci Transl Med 2011;3:95ra73
Published by AAAS
Fig. 3 Serum and BM cytokines before and after CART19 cell infusion.
Michael Kalos et al., Sci Transl Med 2011;3:95ra73
Published by AAAS
Fig. 4 Prolonged surface CAR19 expression and establishment of functional memory CART19 cells in vivo.
Michael Kalos et al., Sci Transl Med 2011;3:95ra73
Published by AAAS