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T Cells with Chimeric Antigen Receptors Have Potent Antitumor Effects and Can Establish Memory in Patients with Advanced Leukemia by Michael Kalos, Bruce L. Levine, David L. Porter, Sharyn Katz, Stephan A. Grupp, Adam Bagg, and Carl H. June Sci Transl Med Volume 3(95):95ra73-95ra73 August 10, 2011 Published by AAAS

T Cells with Chimeric Antigen Receptors Have Potent Antitumor Effects and Can Establish Memory in Patients with Advanced Leukemia by Michael Kalos, Bruce

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T Cells with Chimeric Antigen Receptors Have Potent Antitumor Effects and Can Establish Memory in Patients

with Advanced Leukemia

by Michael Kalos, Bruce L. Levine, David L. Porter, Sharyn Katz, Stephan A. Grupp, Adam Bagg, and Carl H. June

Sci Transl MedVolume 3(95):95ra73-95ra73

August 10, 2011

Published by AAAS

Fig. 1 Schematic representation of the gene transfer vector and transgene, gene-modified T cell manufacturing, and clinical protocol design.

Michael Kalos et al., Sci Transl Med 2011;3:95ra73

Published by AAAS

Fig. 2 Sustained in vivo expansion and persistence in blood and marrow of CART19 cells.

Michael Kalos et al., Sci Transl Med 2011;3:95ra73

Published by AAAS

Fig. 3 Serum and BM cytokines before and after CART19 cell infusion.

Michael Kalos et al., Sci Transl Med 2011;3:95ra73

Published by AAAS

Fig. 4 Prolonged surface CAR19 expression and establishment of functional memory CART19 cells in vivo.

Michael Kalos et al., Sci Transl Med 2011;3:95ra73

Published by AAAS

Fig. 5 Evaluation of clinical responses after infusion of CART19 cells.

Michael Kalos et al., Sci Transl Med 2011;3:95ra73

Published by AAAS