of 18 /18
Systemic Determination Systemic Determination of Neuronal Activity of Neuronal Activity

Systemic Determination of Neuronal Activity

Embed Size (px)

DESCRIPTION

Systemic Determination of Neuronal Activity. Result “from the outside”:. Memory. Environmental. Parameters. afferentation. of the result. Acceptor. of action’s. Decision. Triggering. Result. result. of the action. making. stimulus. Program. of the action. Environmental. Action. - PowerPoint PPT Presentation

Citation preview

Page 1: Systemic Determination of Neuronal Activity

Systemic Determination of Systemic Determination of Neuronal ActivityNeuronal Activity

Page 2: Systemic Determination of Neuronal Activity

In the framework of reactivityparadigm individual's behaviorindividual's behaviorisis aa reaction to stimulus reaction to stimulus. Thisreaction is based on thepropagation of excitationpropagation of excitationalong the reflex arcalong the reflex arc: fromreceptors through centralstructures to effector organs.

1

2

Reactivity

1

1.Stimulus

2.Reaction

Page 3: Systemic Determination of Neuronal Activity

1

2

Reactivity

1

1.Stimulus

2.Reaction

The reactivity paradigm treats neuron as anelement of reflex arc, while its functionis a propagation of excitation.

Thus reactivity paradigm treats neuron quitelogically: neuron, just like an organism,responds to stimuli. Impulses that aneuron receives from other cells act asstimuli, while the response of a neuron isits discharges following the synapticinput.

Page 4: Systemic Determination of Neuronal Activity

In the framework of activityactivity paradigmindividual's behavior isindividual's behavior is a a goalgoal--directed actiondirected action. . The principaldeterminant of a behavior is an eventwhich is not in the past with respectto behaviour, that is, a stimulus, butwhich occurs in the future, a a resultresult,which is understood as a desiredrelation between an organism andenvironment.

1

2

Reactivity Activity

1.Stimulus

2.Reaction

2.Result

1.Action

1

1.Stimulus

2.Reaction

??

Page 5: Systemic Determination of Neuronal Activity

А neuron, like any other livinglike any other livingcellcell, realizes a genetic programwhich requires metabolitesrequires metabolitesreceived from other cellsreceived from other cells..

1

2

Reactivity Activity

2.Result

1

1.Stimulus

2.Reaction

1.Action

2.Result

Page 6: Systemic Determination of Neuronal Activity

Neuronal activityNeuronal activity, like a behavior of anorganism, is notis not a a response response,, but but a a way of way ofchanging the relation to environmentchanging the relation to environment,,""actionaction"" that removes discrepancy between"needs" and microenvironment, causingmodifications in blood flow, metabolic inflowfrom glial cells, activity of other neurons.

1

2

Reactivity Activity

2.Result

1

1.Stimulus

2.Reaction

1.Action

2.Result

Page 7: Systemic Determination of Neuronal Activity

1

2

Reactivity Activity

2.Result

1

1.Stimulus

2.Reaction

1.Action

2.Result

Thus, neuronneuron is not an "encodingelement", "conductor", or "summator", but anan organismorganism withinwithin organismorganism, , providingproviding forfor itsits needsneeds withwith metabolicmetabolicsubstancessubstances receivedreceived fromfrom otherotherelementselements.

Page 8: Systemic Determination of Neuronal Activity

1

2

Reactivity Activity

2.Result

1

1.Stimulus

2.Reaction

1.Action

2.Result

Neuron may provide for its metabolic"needs" only by joining with otheronly by joining with otherelements of an organismelements of an organism to form afunctional system.

Achievement ofAchievement of a a result result of abehavioral act appears assatisfying metabolic "needs" ofneurons, and it stops theirstops theiractivityactivity..

Page 9: Systemic Determination of Neuronal Activity

Result “from the outside”:

Page 10: Systemic Determination of Neuronal Activity

Memory

Motivation

Decisionmaking

Acceptorof action’s

result

Programof the action

Action

Resultof the action

Parametersof the result

Afferentsynthesis

Triggeringstimulus

Environmentalafferentation

Environmentalafferentation

Act n Act n+1 Act n+2T T

Rn

Rn + 1r1 r1 r1r2 r2 r2r3 r3

Page 11: Systemic Determination of Neuronal Activity

"From within", at the level of at the level of separate neurons, separate neurons, achievement of a resultachievement of a result appears as satisfying metabolic "needs" of neurons, and it stops their activitystops their activity.

Page 12: Systemic Determination of Neuronal Activity

А neuron, like anylike anyother living cellother living cell,

realizes a genetic programwhich requires metabolitesrequires metabolitesreceived from other cellsreceived from other cells.. 1

2

Reactivity Activity

2.Result

1

1.Stimulus

2.Reaction

1.Action

2.Result

Page 13: Systemic Determination of Neuronal Activity

The anticipatory nature of reflection that is the principal and specific property of life determines the ability of any individual (both unicellular and multicellular) to prepare for the forthcoming events organized in certain temporal sequences. It is the most fundamental characteristic of the living matter (P. K. Anokhin).

Page 14: Systemic Determination of Neuronal Activity
Page 15: Systemic Determination of Neuronal Activity
Page 16: Systemic Determination of Neuronal Activity

HEALTHY28%

17%

11%

34%

22%

34%

30%

26%

L>M M>L

M>L L~M

Acuteethanol

AcuteethanolALCOHOLIC

Ch

ron

ic e

than

ol

E- E+

Page 17: Systemic Determination of Neuronal Activity
Page 18: Systemic Determination of Neuronal Activity