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Name of Compound Structure
4-Chloro-4'-bromochalcone
4-chloro-4'-fluorochalcone
4-bromo-4'-chlorochalcone
4-bromo-4'-nitrochalcone
4-chloro-4'-hydroxychalcone
Innovation aspect: This is an era in science where we are exploring our ancient roots and delving deep into the molecular mechanisms exhibited in mother nature with the sophistication of modern techniques at our disposal. Combining traditional literature documented by our ancestors as well as recent evidence provided to us on the structural diversity of Chalcones and coumarins (which contributes to their biological potency), we aim to design a class of compounds which could be potentially more effective in treatment of cancer.
Introduction: The burden of cancer is increasing across the World and thus it is the leading cause of deaths in economically developed countries and second leading cause of deaths in developing countries. Cancer is considered to be one of the most intractable diseases because of the innate characteristics of cancer stem cells that can proliferate uncontrollably, avoid apoptosis, invade and metastasize. Despite the advances in chemotherapy, there are no sufficient clinically useful cytotoxic agents that selectively targets cancer cells. Chalcones/ coumarines are natural products that display various biological activities, including anticancer properties. Compelling data from laboratory studies indicate that these compounds have important effects on cancer cell growth and proliferation.
METHODOLOGYMETHODOLOGY
Synthesis of ChalconesChalcones can be produced in laboratory very easily by using condensation reaction in the
presence of suitable catalyst.
Cell-based assays are used for screening collections of compounds to determine if the test molecules have effects on cell proliferation or show direct cytotoxic effects that eventually lead to cell death.
Anukriti Khare, BSc (H)Chem. II year
Bornika Roy, BSc (H)Zoo III year
Jennifer B. Thomas, BSc (H)Bot III year
Rahul , BSc (H) BioSc III year
Rakesh Kumar, BSc (H) Chem III year
Rishi Kodwani, BSc (H) Chem II year
Ritu Bansal, BSc (H) Chem II year
Sandhya Singh, BSc (H) Zoo III year
Sonali Khurana, BSc (H) Chem II year
Sukriti Kapoor, BSc (H) BioSc III year
STUDENTSSTUDENTSDr. Sanjay KumarAssociate ProfessorDepartment of Chemistry
Dr. Shukla SalujaAssistant Professor
Department of Botany
MENTORMENTORProf. Sunil Sharma
Department of ChemistryUniversity of Delhi
Objectives: Designing and synthesis of potential derivatives of Chalcones/ Coumarines using traditional knowledge about plants. Evaluation of Anti-cancer activity of synthesized derivatives using cancer cell lines.
Results and publications :Results and publications :The synthesized chalcones are being screened for anticancer properties using MTT assay and we hope for a positive outcome.A review article entitled ‘Recent developments in antitumor activity of Chalcones’ has been sent for publishing in a reputed journal. The abstract has been approved and acceptance of the review is awaited.
References:References:•Li Pan, Hee-Byung Chai, and A. Douglas Kinghorn, Discovery of new anticancer agents from higher plants, Front Biosci (Schol Ed).2012 ; 4: 142–156•Mondal S, Bandyopadhyay S, Ghosh MK, Mukhopadhyay S, Roy S, Mandal C, Natural products: promising resources for cancer drug discovery. Anticancer Agents Med Chem. 2012 Jan;12(1):49-75.
Dr. Rajendra PhartyalAssistant ProfessorDepartment of Zoology
INVESTIGATORSINVESTIGATORS
FEW OF THE SYNTHESIZED COMPOUNDS
