Your partner in managing your patients’ health, Thorne Research utilizes the latest scienti�c �ndings and o�ers the purest products available on the market, free of binders, unnecessary �llers, and �owing agents that can inhibit your patients’ ability to absorb essential nutrients... experience the Purity-to-Healing Relationship with Thorne Research.

P R AC T I T I O N E R R E F E R E N C E

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. P.O. BOX 25, DOVER, IDAHO 83825 TOLL-FREE 800.228.1966 EMAIL INFO@THORNE.COM WWW.THORNE.COM

How many of your patients could be helped by DaxibeQOL?

Suggested Use: Mix 1 sachet with 4- 6 ouncesof water once or twice daily or as recommended by a health-care practitioner.

DaxibeQOL is a delicious, lemon-flavored,lightly-sweetened formula, without artificialflavors or sweeteners, that mixes easilyin warm or cold liquids.

Amino Acid Cofactors are Necessary for Energy Production in the Krebs (Citric Acid) Cycle within the Mitochondria

axibe

30 Sachets QOL106

DaxibeQOL®S u p p l e m e n t F a c t sServing Size: One SachetServings Per Container: 30 Sachets

Each (6.6 g) Sachet Contains: % DV

*Daily Value (DV) not established.

Other Ingredients: Citric Acid, Fatty Acid Polyglycerol Esters, Sodium Citrate, Hydroxypropylmethylcellulose, Lemon Flavor, Stevia extract (leaf) (Rebaudioside A 95%) Silicon Dioxide, colored with Vitamin B2.

If pregnant, consult your health-care practitioner before using this product.

L-Leucine 1.25 g * L-Lysine (as L-Lysine Chloride) 650 mg * L-Isoleucine 625 mg * L-Valine 625 mg * L-Threonine 350 mg * L-Histidine (as L-Histidine Chloride Monohydrate) 150 mg * L-Cystine 150 mg * L-Phenylalanine 100 mg * L-Methionine 50 mg * L-Tyrosine 30 mg * L-Tryptophan 20 mg *

The comprehensive blend of branched-chain andother essential amino acids in DaxibeQOL has beenvalidated through extensive clinical trials to promotelean muscle mass and muscle strength.*

D QOL®

DaxibeQOL provides substrates to the Krebs Cycle for energy production.*

DaxibeQOL promotes mitochondrial biogenesis*

DaxibeQOL promotes and maintainslean muscle*

Support for: Cachexia, Sarcopenia, COPD, Diabetes, CHD,Exercise, Performance, and Wound Healing

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. *This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

DaxibeQOL® induces mitochondrial biogenesis*

diminished fat synthesis+

stress resistance

gene expressionmitochondrial

biogenesis

nucleus

eNOS

DaxibeQOL amino acid supplementationExerciseCaloric restriction

Amino acid supplementation has been shown to decreasefat synthesis, improve redox status, and improve energy production

via activation of NRF-2 and PGC-1α.*

NO

cGMP

O2

SIRT1

PGC-1α

NRF-2 ?

ATP

The active ingredient formulation in DaxibeQOL® has over 25 years of scienti�c and clinical research

DaxibeQOL for 60 weeks to elderly subjects with type 2 diabetes resulted in decreased fasting blood sugar, post-prandial glucose, HbA1c, and serum insulin, and improvedinsulin sensitivity.Solerte SB, Fioravanti M, Locatelli E, et al. Improvement of blood glucose control and insulin sensitivity during long-term (60 weeks) randomized study with amino acid supplements in elderly subjects with type 2 diabetes mellitus. Am J Cardiol 2008;101:82E-88E.

DaxibeQOL for a period of 6 months and 18 months in elderly subjects resulted insigni�cant increases in whole-body lean mass; signi�cant decrease in fasting blood glucose and serum insulin; improved insulin resistance; signi�cant reduction in serum tumor necrosis factor-alpha; and a signi�cant increase in IGF-1 and in the IGF-1/TNF-alpha ratio. Solerte SB, Gazzaruso C, Bonacasa R, et al. Nutritional supplements with oral amino acid mixtures increases whole-body lean mass and insulin sensitivity in elderly subjects with sarcopenia. Am J Cardiol 2008;101:69E-77E.

DaxibeQOL increases muscle mass by stimulating muscle �ber hypertrophy and improving strength.Kraemer WJ, Ratamess NA, Volek JS, et al. The e�ects of amino acid supplementation on hormonal responses to resistance training overreaching. Metabolism 2006;55:282-291.

12 weeks of DaxibeQOL to elderly subjects improved walking capacity, muscle strength, and heart function.Scognamiglio R, Testa A, Aquilani R, et al. Impairment in walking capacity and myocardial function in the elderly: is there a role for nonpharmacologic therapy with nutritional amino acid supplements? Am J Cardiol 2008;101:78E-81E.

DaxibeQOL for 3 months to COPD patients improved: blood oxygen, cognitive function, general health status, and muscle energy metabolism.Dal Negro RW, Aquilani R, Bertacco S, et al. Comprehensive e�ects of supplemented essential amino acids in patients with severe COPD and sarcopenia. Monaldi Arch Chest Dis 2010;73:25-33.

Cancer patients with cachexia (stage IV): Twenty-�ve individuals given DaxibeQOL, one sachet BID x 8 weeks demonstrated signi�cant improvement in grip strength, serum albumin and ROS. CRP reduced from 25 to 17 (NS, but close – p=0.066).

Madeddu C. Open phase II study on e�cacy and safety of an oral amino acid functional cluster supplementation in cancer cachexia. Mediterr J Nutr Metab 2010;3:165-172.

30 days of DaxibeQOL to elderly subjects with CHF improved exercise capacity, oxygen utilization, and muscle function.Aquilani R, Viglio S, Iadarola P, et al. Oral amino acid supplements improve exercise capacities in elderly patients with chronic heart failure. Am J Cardiol 2008;101:104E-110E.

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. *This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

DaxibeQOL® induces mitochondrial biogenesis*

diminished fat synthesis+

stress resistance

gene expressionmitochondrial

biogenesis

nucleus

eNOS

DaxibeQOL amino acid supplementationExerciseCaloric restriction

Amino acid supplementation has been shown to decreasefat synthesis, improve redox status, and improve energy production

via activation of NRF-2 and PGC-1α.*

NO

cGMP

O2

SIRT1

PGC-1α

NRF-2 ?

ATP

The active ingredient formulation in DaxibeQOL® has over 25 years of scienti�c and clinical research

DaxibeQOL for 60 weeks to elderly subjects with type 2 diabetes resulted in decreased fasting blood sugar, post-prandial glucose, HbA1c, and serum insulin, and improvedinsulin sensitivity.Solerte SB, Fioravanti M, Locatelli E, et al. Improvement of blood glucose control and insulin sensitivity during long-term (60 weeks) randomized study with amino acid supplements in elderly subjects with type 2 diabetes mellitus. Am J Cardiol 2008;101:82E-88E.

DaxibeQOL for a period of 6 months and 18 months in elderly subjects resulted insigni�cant increases in whole-body lean mass; signi�cant decrease in fasting blood glucose and serum insulin; improved insulin resistance; signi�cant reduction in serum tumor necrosis factor-alpha; and a signi�cant increase in IGF-1 and in the IGF-1/TNF-alpha ratio. Solerte SB, Gazzaruso C, Bonacasa R, et al. Nutritional supplements with oral amino acid mixtures increases whole-body lean mass and insulin sensitivity in elderly subjects with sarcopenia. Am J Cardiol 2008;101:69E-77E.

DaxibeQOL increases muscle mass by stimulating muscle �ber hypertrophy and improving strength.Kraemer WJ, Ratamess NA, Volek JS, et al. The e�ects of amino acid supplementation on hormonal responses to resistance training overreaching. Metabolism 2006;55:282-291.

12 weeks of DaxibeQOL to elderly subjects improved walking capacity, muscle strength, and heart function.Scognamiglio R, Testa A, Aquilani R, et al. Impairment in walking capacity and myocardial function in the elderly: is there a role for nonpharmacologic therapy with nutritional amino acid supplements? Am J Cardiol 2008;101:78E-81E.

DaxibeQOL for 3 months to COPD patients improved: blood oxygen, cognitive function, general health status, and muscle energy metabolism.Dal Negro RW, Aquilani R, Bertacco S, et al. Comprehensive e�ects of supplemented essential amino acids in patients with severe COPD and sarcopenia. Monaldi Arch Chest Dis 2010;73:25-33.

Cancer patients with cachexia (stage IV): Twenty-�ve individuals given DaxibeQOL, one sachet BID x 8 weeks demonstrated signi�cant improvement in grip strength, serum albumin and ROS. CRP reduced from 25 to 17 (NS, but close – p=0.066).

Madeddu C. Open phase II study on e�cacy and safety of an oral amino acid functional cluster supplementation in cancer cachexia. Mediterr J Nutr Metab 2010;3:165-172.

30 days of DaxibeQOL to elderly subjects with CHF improved exercise capacity, oxygen utilization, and muscle function.Aquilani R, Viglio S, Iadarola P, et al. Oral amino acid supplements improve exercise capacities in elderly patients with chronic heart failure. Am J Cardiol 2008;101:104E-110E.

Your partner in managing your patients’ health, Thorne Research utilizes the latest scienti�c �ndings and o�ers the purest products available on the market, free of binders, unnecessary �llers, and �owing agents that can inhibit your patients’ ability to absorb essential nutrients... experience the Purity-to-Healing Relationship with Thorne Research.

P R AC T I T I O N E R R E F E R E N C E

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. P.O. BOX 25, DOVER, IDAHO 83825 TOLL-FREE 800.228.1966 EMAIL INFO@THORNE.COM WWW.THORNE.COM

How many of your patients could be helped by DaxibeQOL?

Suggested Use: Mix 1 sachet with 4- 6 ouncesof water once or twice daily or as recommended by a health-care practitioner.

DaxibeQOL is a delicious, lemon-flavored,lightly-sweetened formula, without artificialflavors or sweeteners, that mixes easilyin warm or cold liquids.

Amino Acid Cofactors are Necessary for Energy Production in the Krebs (Citric Acid) Cycle within the Mitochondria

axibe

30 Sachets QOL106

DaxibeQOL®S u p p l e m e n t F a c t sServing Size: One SachetServings Per Container: 30 Sachets

Each (6.6 g) Sachet Contains: % DV

*Daily Value (DV) not established.

Other Ingredients: Citric Acid, Fatty Acid Polyglycerol Esters, Sodium Citrate, Hydroxypropylmethylcellulose, Lemon Flavor, Stevia extract (leaf) (Rebaudioside A 95%) Silicon Dioxide, colored with Vitamin B2.

If pregnant, consult your health-care practitioner before using this product.

L-Leucine 1.25 g * L-Lysine (as L-Lysine Chloride) 650 mg * L-Isoleucine 625 mg * L-Valine 625 mg * L-Threonine 350 mg * L-Histidine (as L-Histidine Chloride Monohydrate) 150 mg * L-Cystine 150 mg * L-Phenylalanine 100 mg * L-Methionine 50 mg * L-Tyrosine 30 mg * L-Tryptophan 20 mg *

The comprehensive blend of branched-chain andother essential amino acids in DaxibeQOL has beenvalidated through extensive clinical trials to promotelean muscle mass and muscle strength.*

D QOL®

DaxibeQOL provides substrates to the Krebs Cycle for energy production.*

DaxibeQOL promotes mitochondrial biogenesis*

DaxibeQOL promotes and maintainslean muscle*

Support for: Cachexia, Sarcopenia, COPD, Diabetes, CHD,Exercise, Performance, and Wound Healing