SUPPORT ADRENALSTM

Protection from Stress.UPGRADEDFORMULA!

120 CAPSULES - RETAIL: $50.00

SUPPORT ADRENAL HEALTH AND HPA FUNCTION• Therapeutic levels of nutrients to support health and function of the adrenal glands• Defends against the damaging effects of stress• Helps with glycemic control• Aids in neurological function• Helps in tissue repair and reducing inflammation• Supports steady energy production• A vital component of every anti-aging regimen

HIGHLIGHTS INCLUDE:

• Capsules made from natural vegetable sources.• Folate now provided in the form of a proprietary and superior 5 –methyltetrahydrofolate (5-MTHF) known as Quatrefolic. This is themost bioavailable source of folate available. With many patients incapable of converting folic acid, this upgrade of folate form is a greatimprovement.• Improved sources of bioflavonoids, including addition of citrus peel complex powder.

FORMULA UPGRADED, MAY 2017

With millions of bottles dispensed worldwide for clinical protocols, as well as daily supplement routines, Support Adrenals has held a place at the top of the list for specialty formulas for nearly 20 years. And effective May 2017, we improved the formula to comply with the latest scientific research. Refer to the following pages for the new Supplement Facts and formula details.

THE ADRENAL GLANDS AND STRESSAdrenal health is required for production of cortisol and DHEA, hormones involved in HPA function for managing and responding to stress. Support Adrenals is clinically proven to help nourish and support the adrenals by enhancing the body’s ability to deal with stressors of all kinds. This synergistic formula of balanced B-vitamins, minerals, bioflavonoids, and supportive co-factors can help in a myriad of ways to

improve health and recover from stress-related conditions.

307 - 212 - 6600800 - 570 - 2000

307 - 426 - 5058www.biomatrixone.com

These statements have not been evaluated by the Food and Drug Administration.

CONTAINING

2 capsules containAmount

Per Serving

% Daily

ValueVitamin C (Ascorbic Acid and Ascorbyl Palmitate) 100 mg 111%

Thiamine (as Thiamine Mononitrate) 50 mg 4,167%

Riboflavin 50 mg 3,846%

Niacin (as Niacinamide and Niacin) 50 mg 313%

Vitamin B6 (as Pyridoxine HCl and Pyridoxal- 5Phosphate 50 mg 111%

Folate (as [6S]-5-Methyltetrahydrofolic Acid Glucosamine Salt Quatrefolic®)

400 Mcg DFE 100%

Vitamin B12 (as Cyanocobalamin) 100 mcg 4,167%

Biotin 2,000 mcg 6,667%

Pantothenic Acid (as Calcium-D-Pantothenate) 200 mg 4,000%

Choline (as Choline Bitartrate) 20 mg 4%

Zinc (as Zinc Citrate) 1.5 mg 14%

Copper (as Copper Citrate) 0.55 mg 61%

PABA (Para-Aminobenzoic Acid) 75 mg *

Citrus Bioflavonoid Peel Complex Powder 50 mg *

Inositol 50 mg *

Eleuthero Root Extract 50 mg *

Rosemary Leaf Extract 36 mg *

Naringin 36 mg *

Hesperidin Methyl Chalcone 36 mg *

Rutin 10 mg *

DHEA (Dehydroepiandrosterone) 8 mg *

SUPPLEMENT FACTSServing Size: 2 Capsules | Servings: 60

* % Daily Value not established.Other Ingredients: Natural Vegetable Capsules,Microcrystalline Cellulose, and Vegetable Stearate.

SUPPORT ADRENALSTM

Protection from Stress.

307 - 212 - 6600800 - 570 - 2000

307 - 426 - 5058www.biomatrixone.com

These statements have not been evaluated by the Food and Drug Administration.

Vitamin C is utilized by the adrenal glands in the production of all of the adrenal hormones, most notably cortisol. Ascorbic acid is a cofactor required

both in catecholamine biosynthesis and in adrenal

steroidogenesis.

Bioflavonoids enhance the absorption and stability of vitamin C and improve its

utilization in the cells. Under stress, vitamin C is rapidly used up in the production

of cortisol and related stress response hormones.

NOURISH

C-BIOFLAV BLEND

Helping the body adapt to stress requires positive

changes to lifestyle behaviors, resolving underlying

causes and supplementing with powerfully effective

combinations of nutrients.

To this end, these Support Adrenals components

are combined to support stress adaptation. Through

their singular potencies and dynamic synergistic

influences, these are factorsd which help to regulate

healthy HPA axis function.

REGULATE

HPA AXIS FACTORS

Well-known to play essential roles in physiology, B vitamins

are especially important in promoting HPA axis function and nourishing the adrenal

glands.

The mechanisms of action are primarily based in

the vitamins’ roles in the conversion of coenzymes involved in such functions

as metabolizing glucose into energy and modulating the

stress response.

MAINTAIN

B VITAMIN CORE

The primary stress response hormones produced by the adrenal glands are DHEA and pregnenolone. Under

chronic stress, the production of these hormones becomes

compromised.

In this formula, we use a small amount of each hormone to cause a homeopathic

influence intended to promote healthy function without overstimulation. This low-dose fanning of

the conversion pathways is discreet enough to be used

with hormone therapy as well as daily maintenance support.

• DHEA• Pregnenolone

INFLUENCE

TRACE HORMONES

SUPPORT ADRENALS: THE FORMULAThe ingredients in Support Adrenals are combined in carefully considered amounts in order to promote proper homeostasis of cortisol, support healthy hypothalamic - pituitary - adrenal (HPA) axis function, and replace nutritional deficiencies that result from chronic stress.

Support Adrenals works. Hundreds of thousands of patients and clinicians have experienced the efficiacy of this legendary formula since 1999, as the cornerstone of clinical protocols and maintenance programs alike.

See Reverse for Ingredient Details

• Vitamin C • Citrus Peel Complex • Hesperidin• Naringin• Rutin

• Choline• Inositol • Rosemary Leaf • Eleuthero Root • PABA• Copper• Zinc

• Niacin (B3)• Pyridoxine (B6)• Cobalamin (B12)• Pantothenic Acid

(B5)• Folate (B9)• Biotin (B7)• Thiamine (B1)• Riboflavin (B2)

307 - 212 - 6600800 - 570 - 2000

307 - 426 - 5058www.biomatrixone.com

These statements have not been evaluated by the Food and Drug Administration.

SUPPORT ADRENALS: THE FORMULA Vitamin C: With enhanced absorption from the complementary bioflavonoids in the formula, this blend of water-soluble Ascorbic Acid and fat - soluble Ascorbyl Palmitate acts to support biosynthesis of corticosteroids and nourishment of the adrenal glands.

Bioflavonoid Blend • Citrus Peel Complex – This broad spectrum bioflavonoid mix is composed of stabilized powder from multiple citrus peel sources, representing a powerful broad-spectrum antioxidant role in the formula. This complex, along with the other bioflavonoids listed below, also contributes to improved glycemic control, a critical part of any stress management plan. • Hesperidin Methyl Chalcone and Naringin – Besides their well-documented benefits for supporting ascorbic acid synthesis and strengthening capillary permeability, hesperidin and naringin both play important roles in preventing the progression of hyperglycemia, partly by increasing hepatic glycolysis and glycogen concentration and/or by lowering hepatic gluconeogenesis. • Rutin – This extensively studied bioflavonoid has its greatest effect within the bloodstream and capillary beds, as a powerful antioxidant with inflammatory traits. By inhibiting the mechanism of action of several mediators of inflammation, it helps in preventing inflammation. Reduction of inflammation is a crucial component of HPA axis recovery protocols.

C-BIOFLAV BLEND

Choline & Inositol: Together, choline and inositol are considered a nootropic force. They not only promote cell health and helps lipid transport, they also manufacture the fuel from which choline can be metabolized, ensuring that the brain is able to synthesize acetylcholine, the neurotransmitter most strongly associated with cognitive enhancement and memory formation. Acetylcholine acts as a sort of “lubricant” for all brain function, thereby playing a role as a benefactor to HPA axis health. Rosemary Leaf Extract: Rosemary leaf is a powerful antioxidant that supports cognitive abilities and helps fight against poor memory, digestive problems and bad circulation. It contains compounds which prevent certain enzymes from causing destruction of the neurotransmitter acetylcholine. Furthermore, rosemary contains antioxidants that protect the brain is reported by many to elicit a sense of calm (an essential goal in any HPA stress management plan). Eleuthero Root Extract: Renowned as an adaptogen, eleuthero (from Siberian ginseng root) also works to balance serotonin, norepinephrine, dopamine, and epinephrine. And its active chemical components, eleutherosides, are known to inhibit the stress response by reducing the activity of the adrenal cortex. Studies demonstrate that compounds in eleuthero support adrenal function by decreasing adrenal hypertrophy, blunting fatigue, bolstering immunity, and inhibiting elevated cortisol levels in response to stress. PABA: PABA is a component of many biological systems and participates in numerous metabolic processes. It functions as a coenzyme in the conversion of certain chemicals involved in DNA repair. It has also been suggested that PABA has an antifibrosis activity, increasing oxygen uptake at the tissues. This increase in oxygen may enhance monoamine oxidase activity, which aids in metabolism of serotonin, norepinephrine, and dopamine. Copper-Zinc: Zinc deficiency can impair a healthy stress response, and zinc appears to moderate cortisol release with stress. In humans, adequate zinc levels can help stabilize serum cortisol levels post operatively, preventing a sharp increase in cortisol. Copper is included in the formula to balance the zinc. Copper has a key role in neurotransmitter balance and formation.

HPA AXIS FACTORS

DHEA: Dehydroepiandrosterone (DHEA) is the most common adrenal steroid hormone in the body. It is naturally produced from cholesterol in a variety of tissues, most notably the adrenal glands. DHEA is the parent hormone of both the androgens and the estrogens. Pregnenolone: Pregnenolone is the “mother” hormone which produces other hormones like estrogens, progesterone, testosterone, cortisol, and DHEA. This neuroprotective hormone has powerful effects on aging, memory, mood, sexuality, sleep, and so much more. It helps raise brain levels of acetylcholine, the neurotransmitter needed for healthy cognition.

TRACE HORMONES

Niacin (Vitamin B3): Besides its most renowned benefits, such as lowering cholesterol, B3 is a strong methyl acceptor that has the potential to moderate stress-induced overproduction of neurotransmitters. Pyridoxine (Vitamin B6): Vitamin B6 is a cofactor for numerous enzymatic processes throughout the body. Recent evidence supports the role of vitamin B6 in the cellular stress response for protection from free radicals and other environmental stressors. In addition, vitamin B6 is a necessary cofactor for the metabolism of several important neurotransmitters associated with stress, most notably GABA, 5-HTP, serotonin, and dopamine. Cobalamin (B12): Vitamin B12 is critical for the functioning of the brain and nervous system and for the formation of blood. It affects metabolism in every cell in the body and is directly involved in energy production. Pantothenic Acid (B5): In animal studies, pantothenic acid has been shown to raise cortisol levels. Pantothenic acid also appears to improve stress resiliency, acting as a modulating agent for adrenal function. Pantothenic acid is a precursor for acetyl coenzyme A, a compound essential for the production of corticosteroid hormones. Folate (B9, as 5-MTHF): Folate helps support adrenal function, maintain a healthy nervous system, and is a required component of numerous metabolic processes. It is the primary B vitamin involved in the formation of dopamine, norepinephrine, and serotonin. Support Adrenals contains a proprietary form of folate called Quatrefolic ([6S]-5-Methyltetrahydrofolic Acid Glucosamine Salt). Tetrahydrofolic acid acts as a coenzyme in several vital metabolic reactions and in the metabolism of several important amino acids. Biotin (B7): Biotin plays a major role in energy production by acting as a coenzyme for several carboxylase enzymes involved in the metabolism of fatty acids and amino acids. It also plays numerous roles in maintaining healthy blood sugar balance such as: stimulating glucose induced insulin secretion, enhancing insulin sensitivity and accelerating glucose metabolism in the liver and pancreas. Biotin also activates glucokinase, a critical enzyme involved in glucose utilization. Thiamine (B1): Thiamine is involved in many body functions, including nervous system and muscle function, the flow of electrolytes in and out of nerve and muscle cells, digestion, and carbohydrate metabolism. Riboflavin (B2): The main role of riboflavin is to help with the conversion of carbohydrates to energy in the body. It also helps to convert vitamin B6 and folate to their active forms.

B VITAMIN CORE

307 - 212 - 6600800 - 570 - 2000

307 - 426 - 5058www.biomatrixone.com

These statements have not been evaluated by the Food and Drug Administration.

CONTAINING