Subcutaneous keloid diagnosed and monitored by high-frequency ultrasound

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<ul><li><p>Posters -Non-invasive methods in skin srudy S261 </p><p>and the control group were as follows: +lO f 3 vrn @ &lt; 0.005) and 4.2 f 2 pm (p &lt; 0.2) for epidermal thickness, +0.04 rt 0.02 mm @ &lt; 0.2) and -0.03 f 0.02 mm @ &lt; 0.2) for dermal thickness, +0.03 f 0.01 0, &lt; 0.005) and -0.02 f 0.01 @ &lt; 0.05) for elasticity, and -53 f 14 KPa @ &lt; 0.001) and -2 f I6 KPa (p &lt; 0.9) for stiffness. Difference between treatment groups for elasticity only was statistically significant @ &lt; 0.01, test Bonferroni). </p><p>Taken together, these results indicate that retinaldehyde has some beneficial effects on skin ageing. </p><p>I P323 The influence of different irritation models and assessment methods on the evaluation of skin barrier creams and emollients </p><p>G. Richter, St. GroBmann. Dep. of Dermatology TU Dresden, Germany </p><p>Aim: Are the results from approved occlusive repetitive ir- ritation tests with SLS comparable to those from open use test with disinfectants? Are the assessment data from various bioengineering methods and visual scores concordant? </p><p>Methods: Skin irritation (9d) with SLS 1% and SLS 2% (big Finn Chambers) or with the skin disinfectant Steryllium@ (open, 3 x 3O/d) on 21 human volunteers; 3 different treatment regimes and untreated control; assessments: TEWL, chromame- try (a, b, L), skin capacitance, visual scores. </p><p>Results: The results correspond in proving the special skin barrier preparations to be most effective. The differences be- tween the occlusive irritation with SLS 1% and SLS 2% respectively, were only marginal. From the simulated surgical skin disinfection with Steryllium@, however, resulted different ranking data for the untreated controls and the applications of Ungt. Ale. Lan. aquos. The various assessment methods agreed in principel but not in all details. Correct evaluations of differ- ent skin protective agents demand: similar irritation models, a battery of assessment methods and right statistics. </p><p>I P324 Subcutaneous keloid diagnosed and monitored by high-frequency ultrasound </p><p>H. Egekvist. K. Thestrup-Pedersen, P. Bjerring. Department of Dermatology, Marselisboq Hospital, Aarhus University Hospital, Aarhus, Denmark </p><p>Objectives: This report describes ultrasound examination of a subcutaneous keloid and regression due to treatment. </p><p>Methods and Materials: A 56-year-old woman developed sleep-disturbing intermittent pain in the upper part of a 15 cm long midline scar following hysterectomy. Clinical examination by several physicians did not show any abnormality. We exam- ined the painful acea using 20 MHz ultrasound. This revealed a keloid extending subcutaneously from the dermal/subcutaneous border. During 5 months the patient received 4 injections of intralesional triamcinolone acetonide 10 mg/ml. The depth of injection was each time guided by ultrasound examination performed just prior to the injection. </p><p>Results: After each individual treatment a brief relief of the painful sensation was reported, and at the last examination, 5 months after the initial treatment, the painful sensation had dis- appeared. Following the treatments the subcutaneous extension </p><p>of the keloid was reduced from 1.2 to 0.9 mm, and the skin thickness was reduced from 3.8 to 2.8 mm. </p><p>Conclusion: Ultrasound examination is useful for exami- nation of keloids, especially when deeply located, and for monitoring of the physical reduction during treatment. </p><p>I P325 Effect of EmlaB cream on skin thickness and subcutaneous venous diameter </p><p>H. Egekvist, P Bjerring. Department of Dermatology, Marselisborg Hospital, Aarhus University Hospital, Aarhus, Denmark </p><p>Questions have been raised whether blanching of the skin following EMLA application is due to vasoconstriction of the veins and/or hydration of the epidermis. </p><p>Objectives: The aim was to evaluate subcutaneous venous diameter and skin thickness before and after application of EMLA cream. </p><p>Materials and Methods: lXventy healthy children, 3-11 years, were included. Veins suitable for venepuncture were identified on the dorsum of the hand or in the antecubital fossa. EMLA cream (Astra, Sweden), 2.5 g was applied under occlu- sion for 60-70 min. High-frequency 20 MHz ultrasound B-scan examination of the veins and overlying skin were conducted immediately after removal of cream, and after 15 min of air exposure. </p><p>Results: Compared to baseline the mean (&amp; S.E.M.) percent change of vein diameter after removal of EMLA cream .was -7.6% (&amp; 6.1%) and after 15 min -13.5% (&amp; 4.6%). Com- pared to baseline mean percent change of skin thickness after removal of EMLA cream was +19.3% (&amp; 6.6%), and after 15 min of removal +8.8% (* 5.7%). </p><p>Conclusion: These data suggest both a reduction of vein di- ameter and an increase of skin thickness following application of EMLA cream. </p><p>I P326 Assessment of skin aging with principal component analysis </p><p>C. Guinot, D. MaIvy, M. Tenenhaus3, M. Dubourgeat, F. Morizot, I. Le Fur, E. Tschachler,4. CE.R.I.E.S., Neuilly/Seine; INSERM U334 Bonieaux; jHEC Group, Jouy en Josas, France: 4 University of Vienna, Henna, Austria </p><p>The effects of skin aging - chronological, actinic and hormonal - range from minor esthetic to pathological problems. The present study, conducted on 654 women aged 18-70, aimed to propose a method to quantify visible skin aging with a global indicator assessing chronological, actinic and hormonal aging effects, based on clinical signs. Using principal com- ponent analysis, a cutaneous age indicator was constructed with signs of aging assessed on diierent facial areas (wrinkles, slackening, dyschromia, vascular aging and pilosity). To explain discrepancies between chronological age and the indicator, a mathematical model was constructed using multiple regres- sion analysis. The skin aging indicator increased according to smoking habits, fair phototype (</p></li></ul>


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