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Stroke Thrombolysis Pathway
This document is to be used in conjunction with the ‘Medical Care Management for Stroke Patients’ document. It is also the front page of the contact assessment; it is to be photocopied with the referral details when referring the patient to any other Health Care Professional.
Ward / Dept: FGH RLI WGH
Demographic Information Next of Kin/Significant other Information Affix patient label
Unit /ID No. 1.Name
Name Address
Address
Telephone No. Night Call
Relationship Next of kin Emergency contact
Post Code Key holder Main Carer
Date of Birth Age 2.Name
Religion Address
Telephone Number
Preferred Name Telephone No. Night Call
Occupation Relationship Next of kin Emergency contact
Ethnic origin Gender M F Key holder Main Carer
GP Name/Surgery Discharge Address/phone number if different above
Telephone Number
Dentist
Reason for admission
Social
Admitted from Home Nursing Home Residential Home Other
Lives Alone Partner/Relative Dependants specify
In a House Bungalow Sheltered Other
Patient has a social worker (if yes, identify) Contacted
Admission/Discharge Information
Date/Time of Admission Named Nurse
Estimated Date of Discharge ID Band in situ Disclaimer Signed
Actual Date/Time Discharge Patient understands reason for admission
Consultant Relatives/Carer aware of admission
Bed/Trolley/Room Number Relative/Carer understands reason for admission
Transferred to: Ward Date Time
Ward Date Time
Ward Date Time
2
Instructions for use.
All staff using the Stroke Thrombolysis pathway please sign sample signature record below.
This document is to be filed in the patients case notes on discharge.
Print Name Full Signature Initials Professional Title Date
3
Cardiac and Stroke Networks in Lancashire & Cumbria
STROKE THROMBOLYSIS PATHWAY
This Document is Private and Confidential
Visitors and members of the public must not view without
the consent of the patient.
Patient Information
This is a Multidisciplinary Integrated Care Pathway (ICP).
The pathway will be kept at the foot of your bed as it is a document that all members of staff will refer to whilst providing your care, however if you wish it to be kept at the Nursing station please inform the Nursing staff.
It contains a record of your planned treatment/management, if you want to know more about your care please follow the pathway.
If you have any questions please do not hesitate to ask one of the nursing staff or doctors.
Remember this pathway is a guide to your expected care.
As an individual your health care requirements may vary from this pathway.
Do not worry if events do not occur at the exact time stated in the pathway, patient’s progress at different rates and the team involved in your care will use their professional judgement to adapt your care accordingly.
Any variation from the pathway will be recorded and explained to you at your request.
If you would like to know more about how we use your information please ask a member of staff for the leaflet “How we use your Health Records”
4
EVENT TIME (24 hr clock)
DELAYS
Stroke onset
Ambulance arrived at scene
Ambulance departed scene
Ambulance arrived at ED
Stroke team bleeped
Stroke team arrived in ED
Patient left ED
CT scan completed
Thrombolysis started
Transfer to CCU
Transfer to ASU
Stroke Thrombolysis – Timing Sheet (24 hr clock)
5
FOR THE ATTENTION OF ALL STAFF
This Integrated Care Pathway has been developed for use as a plan of care for patients:
…………………………………………………………………………………………..
It is intended as a guide only; all staff must maintain professional responsibility and accountability when
using this pathway.
Decisions regarding an individual patient’s care remain at the discretion of the professional.
Please read instructions below and sign accountability section before using the pathway.
Instruction and information for staff
This pathway is to be completed by ALL members of the multidisciplinary team
involved in the patients care and will form part of the patients health record
All sections (where relevant) must be completed
All professionals using this pathway must complete all parts of the accountability
section
It supports decision making but does not constrain your clinical autonomy
Where available the pathway is evidence-based
When an activity has been completed, sign and record the time. If responsibility
for completion of an activity is shared all disciplines must sign
In exercising professional judgement alteration from the pathway must be noted
as a variance and must be recorded on the variance sheet
Please note variances may be positive or negative
Put a V in the box next to the activity and then record the variance on the
variance sheet
Record an explanation of the variance on the variance sheet
Record action taken as a result of the variance on the variance sheet
There is a multidisciplinary notes/communication section to record e.g. additional
care given. These must be signed and dated
Any additional documentation e.g. blood results must be filed with the ICP in the
patients case notes upon discharge
If you have any queries about using the ICP please contact the author/originator
6
ONCE COMPLETED PLEASE FILE ICP IN PATIENTS HOSPITAL CASENOTES
Acute Stroke Thrombolysis Pathway
Write patient details or affix Identification label
Hospital Number: Name: Address: Date of Birth: NHS Number:
Abbreviations used in this section to be listed here with the full description:
GCS Glasgow Coma Score
NG Nasogastric tube
IM Intramuscular
NIHSS National Institute Health Stroke Scale
BP Blood pressure
FBC Full Blood Count
BS Blood Sugar
7
(* If BS < 3.5millimols treat urgently and reassess once blood glucose normal)
Date & Time of symptom onset _________________ BP = GCS Best eye response Best motor response Best verbal response Has there been any loss of consciousness or syncope? Y (-1) N (0) Has there been any seizure activity? Y (-1) N (0)
Is there a NEW ACUTE onset or on awakening from sleep: Asymmetric facial weakness Y (1) N (0) Asymmetric arm weakness Y (1) N (0) Asymmetric leg weakness Y (1) N (0) Speech Disturbance Y (1) N (0) Visual Field Deficit Y (1) N (0)
TOTAL SCORE (-2 to +5)
A score > 0 indicates possible stroke Signature: ……………………………… Print Name:………………………………… Designation: ……………………………. Date: / /
*BS
Abbreviations used in this section to be listed here with the full description:
ROSIER = Recognition of Stroke in the Emergency Room
BS = Blood Glucose
GCS = Glasgow Coma Score
BP = Blood Pressure
ED = Emergency Department
ROSIER
8
The following MUST be answered YES before considering thrombolysis:
ROSIER > 0 YES
Clear time of onset within the previous 2 hours YES
Age between 18 – 80 years. YES
Patient NOT comatose or severely obtunded YES
NO seizure activity YES
Patient previously independent YES
Blood glucose between 2.8 and 22 mmols (BM sufficient) YES
Patient is NOT on warfarin (or anticoagulants) YES
IF the answer to the above questions are ALL YES then page the Stroke Team, insert TWO cannulae and send URGENT bloods – FBC, biochemistry screen, glucose, coagulation screen and group and save. Weight if possible.
IF ALL YES CONTACT STROKE TEAM AND COMMENCE NURSING CARE PATHWAY
IF ANY ARE ANSWERED NO THEN PATIENT IS NOT SUITABLE FOR
THROMBOLYSIS
Signature: Print name: Designation: Date:
Emergency Department
Acute Stroke Thrombolysis
Abbreviations used in this section to be listed here with the full description:
ROSIER= Recognition of Stroke in the Emergency Room
Mmols= millimols
BS = Blood Glucose
FBC= Full blood count
9
Inclusion criteria for stroke; The following must be answered YES:
Does the patient have symptoms of acute stroke? YES
Was the patient previously independent? YES
Age between 18 and 80? YES
Is there a clear time of onset within the last 120 minutes (2 hours) YES
Is there a measurable deficit on the NIH stroke scale? (5 - 25) YES
Exclusion criteria for stroke;
Was there a seizure at the time of symptom onset? NO
Is there a history of intracranial hemorrhage? NO
Is the history suggestive of SAH? NO
Is systolic BP > 185 mmHg BP: NO
Is diastolic BP > 110 mmHg NO
Has any new BP treatment been given to attain these limits? NO
Has the patient been given anticoagulant treatment within the last 48 hours, with an increased PTT?
NO
Has there been arterial puncture at a non-compressible site within the last 7 days?
NO
Has the patient undergone major surgery within the last 2 weeks? NO
Has there been any GI or urinary tract hemorrhage within the last 3 weeks?
NO
Has the patient suffered a stroke within the last 3 months? NO
Has the patient suffered a head trauma within the last 3 months? NO
History of anaphylaxis to rtPA? NO
Is plasma glucose < 2.7 or > 22.2 mmols/L? NO
If available
Is PT > 15 seconds? NO
Is platelet count < 100,000? NO
Following CT scan – must be answered YES
Has the CT brain scan since onset of stroke excluded haemorrhage? YES
Has the CT scan been reviewed by the stroke thrombolysis lead? YES
Has thrombolysis been discussed with patient and / or family? YES
Information sheet given and verbal consent / assent documented YES
Is there a monitoring bed available YES
Modified Rankin Score (note: this is a stroke outcome scale, and should be interpreted with caution for causes of disability other than previous stroke) Description Score No symptoms at all 0 No significant disability despite symptoms; able to carry out all usual duties and activities. 1 Slight disability; unable to carry out all previous activities, but able to look after own affairs without assistance
2
Moderate Disability; requiring some help, but able to walk without assistance 3 Moderately severe disability; unable to walk without assistance and unable to attend to own bodily needs without assistance
4
Severe disability; bedridden, incontinent and requiring constant nursing care and attention 5 Dead 6
Total Score
Thrombolysis for acute stroke checklist
Stroke Team Assessment
10
National Institute of Health Stroke Scale (NIHSS) Pre 2 hrs
24hrs
7 day
1a Level of Consciousness (LOC)
Alert- keenly responsive Drowsy- rousable by minor stimulation to obey, answer, or respond Stuporous- requires repeated stimulation to attend, or is obtunded and requires strong or painful stimulation to make movements (not stereotyped) Comatose- responds only with reflex motor or autonomic effects or totally unresponsive, flaccid
0 1 2 3
0 1 2 3
0 1 2 3
0 1 2 3
1b LOC Questions
Answers both correctly Answers one correctly Both incorrect Patient is asked to state the month & his / her age
0 1 2
0 1 2
0 1 2
0 1 2
1c LOC Commands
Obeys both correctly Obeys one correctly Both incorrect Patient is asked to open & close eyes, grip & release normal hand
0 1 3
0 1 3
0 1 3
0 1 3
2. Best Gaze Normal Partial gaze palsy- gaze is abnormal in one or both eyes, no forced deviation/total gaze paresis Forced deviation- or total gaze paresis not overcome by oculocephalic manoeuvre
0 1 2
0 1 2
0 1 2
0 1 2
3.Visual Fields No visual loss(or in a coma) partial hemianopia complete hemianopia bilateral hemianopia-including cortical blindness
0 1 2 3
0 1 2 3
0 1 2 3
0 1 2 3
4. Facial Palsy Normal Minor- flattened nasolabial fold, asymmetry on smiling Partial- total or near total paralysis of lower face Complete- absent facial movement in upper and lower face and lower face on one or both sides
0 1 2 3
0 1 2 3
0 1 2 3
0 1 2 3
5. Best Motor RIGHT LEG
No drift- holds limb at 90 degrees for full 10 seconds Drift- drifts down but does not hit bed Some effort against gravity No effort against gravity No movement
0 1 2 3 4
0 1 2 3 4
0 1 2 3 4
0 1 2 3 4
6. Best Motor LEFT LEG
No drift- holds limb at 90 degrees for full 10 seconds Drift- drifts down but does not hit bed Some effort against gravity No effort against gravity No movement
0 1 2 3 4
0 1 2 3 4
0 1 2 3 4
0 1 2 3 4
7. Best Motor RIGHT ARM
No drift- holds arm at 45 degrees for full 5 seconds Drift- drifts down but does not hit bed Some effort against gravity No effort against gravity No movement
0 1 2 3 4
0 1 2 3 4
0 1 2 3 4
0 1 2 3 4
8. Best Motor LEFT ARM
No drift- holds arm at 45 degrees for full 5 seconds Drift- drifts down but does not hit bed Some effort against gravity No effort against gravity No movement
0 1 2 3 4
0 1 2 3 4
0 1 2 3 4
0 1 2 3 4
11
9. Limb Ataxia Absent(or in coma) Present in 1 limb Present in 2 or more limbs
0 1 2
0 1 2
0 1 2
0 1 2
10. Sensory Normal Partial loss- patient feels pinprick is less sharp or is dull on affected side Dense loss(or in coma)- patient is unaware of being touched on face, arm, leg
0 1 2
0 1 2
0 1 2
0 1 2
11. Best Language
No dysphasia Mild- moderate dysphasia obvious loss of fluency or comprehension, without significant limitation on ideas expressed or form of expression. Makes conversation about provided material difficult or impossible, e.g. examiner can identify picture or naming card from patient’s response. Severe dysphasia- all communication is through fragmentary expression; great need for inference, questioning, and guessing by the listener who carries burden of communication. Examiner cannot identify materials provided from patient response Mute- no usable speech or auditory comprehension, or in coma.
0 1 2 3
0 1 2 3
0 1 2 3
0 1 2 3
12. Dysarthria Normal articulation Mild- moderate dysarthria- patient slurs some words can be understood with some difficulty. Unintelligible or worse- speech is so slurred as to be unintelligible (absence of or out of proportion to dysphasia) or is mute / anarthic, or in coma
0 1 2
0 1 2
0 1 2
0 1 2
13.Neglect No neglect(or in a coma) Partial neglect- visual, tactile, auditory, spatial, or personal inattention or extinction to bilateral simultaneous stimulation in one of the sensory modalities Complete neglect- profound hemi-inattention or hemi-inattention to more than one modality. Does not recognise own hand or orients to only one side of space
0 1 2
0 1 2
0 1 2
0 1 2
Total Score
12
Alteplase (t-PA) Dosage Schedule for Acute Stroke
Vol. Of 1mg/1ml t-PA Vol. Of 1mg/1ml t-
PA
Patient weight (Kg) Total dose at
0.9mg/kg (mg) 10%
Bolus (ml) 90% Infusion
(ml) Patient
weight (Kg) Total dose at
0.9mg/kg (mg) 10%
Bolus (ml)
90% Infusion
(ml)
40 36 3.6 32.4 70 63 6.3 56.7
41 36.9 3.7 33.2 71 63.9 6.4 57.5
42 37.8 3.8 34 72 64.8 6.5 58.3
43 38.7 3.9 34.8 73 65.7 6.6 59.1
44 39.6 4 35.6 74 66.6 6.7 59.9
45 40.5 4.1 36.4 75 67.5 6.8 60.7
46 41.4 4.1 37.3 76 68.4 6.8 61.6
47 42.3 4.2 38.1 77 69.3 6.9 62.4
48 43.2 4.3 38.9 78 70.2 7 63.2
49 44.1 4.4 39.7 79 71.1 7.1 64
50 45 4.5 40.5 80 72 7.2 64.8
51 45.9 4.6 41.3 81 72.9 7.3 65.6
52 46.8 4.7 42.1 82 73.8 7.4 66.4
53 47.7 4.8 42.9 83 74.7 7.5 67.2
54 48.6 4.9 43.7 84 75.6 7.6 68
55 49.5 5 44.5 85 76.5 7.7 68.8
56 50.4 5 45.4 86 77.4 7.7 69.7
57 51.3 5.1 46.2 87 78.3 7.8 70.5
58 52.2 5.2 47 88 79.2 7.9 71.3
59 53.1 5.3 47.8 89 80.1 8 72.1
60 54 5.4 48.6 90 81 8.1 72.9
61 54.9 5.5 49.4 91 81.9 8.2 73.7
62 55.8 5.6 50.2 92 82.8 8.3 74.5
63 56.7 5.7 51 93 83.7 8.4 75.2
64 57.6 5.8 51.8 94 84.6 8.5 76.1
65 58.5 5.9 52.6 95 85.5 8.6 76.9
66 59.4 5.9 53.5 96 86.4 8.6 77.8
67 60.3 6 54.3 97 87.3 8.7 78.6
68 61.2 6.1 55.1 98 88.2 8.8 79.4
69 62.1 6.2 56 99 89.1 8.9 80.2
100kg &
over 90 9 81
13
Integrated Care Plan
Restrictions for 24 hours (variants to this MUST be documented):
Patient are ADVISED to be on Bed Rest
AVOID Nasogastric tube
NO central venous access, arterial puncture or IM injections
NO anticoagulants, aspirin or non-steroidal anti-inflammatory drugs
NO urinary catheter
Measurements / Interventions
Timing Actions Signature
Intravenous Recombinant tissue plasminogen activator (Alteplase)
10% is given as bolus. The remaining over a period of sixty minutes.
Dosage 0.9mg per Kg. Maximum 90mg. As per dosage schedule NO OTHER INFUSIONS THROUGH SAME CANNULA
Glasgow Coma Score
Every 15 minutes for 1 hour before infusion
If GCS < 2 points inform medics, increase frequency and complete NIHSS
Every 15 minutes for 2 hours after commencing infusion
Then every 30 minutes for the following 6 hours
Then hourly until 24 hours after starting infusion
NIHSS Prior to commencement of infusion
Deterioration > 4 points inform medics – repeat CT scan
Repeat sooner if change GCS, as indicated above
2 hours following commencement of infusion
24 hours following infusion and at 7 days
Heart rate and rhythm
Continually via the cardiac monitor
Rate < 50 or >120 inform medics
OR
NEW AF or arrhythmia. Do 12 lead
ECG and inform medics
Oxygen Saturation
Continually via the cardiac monitor
If saturations < 95%:
Check airway, reposition and suction if necessary.
14
Check for obstruction: Observe tongue for signs swelling or excessive bleeding mouth teeth and gums Give O2 via mask or nasal cannula 24%. Inform medics for review
Blood pressure RECORD using a manual cuff
Every 15 minutes for 1 hour before infusion. If Bp > 185/110 repeat in 5-10mins if remains high treat
Maintain Bp BELOW 185mmHg systolic and 110mmHg diastolic – On 2 consecutive readings 5-10 minutes apart.
Every 15 minutes for 2 hours after commencing infusion
Labetalol 10mg IV over 2 mins then 10-20 every 10-15mins up to a maximum 150 , stop when response adequate)
Then every 30 minutes for following 6 hours
Then hourly until 24 hours after starting infusion
Temperature Every 15 minutes for 1 hour before infusion
Core temp >37.8oc (using temporal artery thermometer) Cool. Remove clothing, use fans or tepid sponging. Give Paracetamol 1gram 6 hourly. Orally or PR >38.5 oc. Infective process. Sputum. MSU. Blood cultures. Inform medics.
Every 15 minutes for 2 hours after commencing infusion
Then every 30 minutes for following 6 hours
Then hourly until 24 hours after starting infusion
Blood Glucose Record on admission. If abnormal or diabetic record 4 hourly
< 3 mmols – Inform medics and give glucose as prescribed >10 mmols – inform medics. Consider insulin therapy.
15
Observe for:
Overt bleeding
Check patient for external signs of bleeding when carrying out observations. Skin, gum and nose bleeding usually do not require action
Other bleeding – STOP tPA. Compress site if possible Inform medics Give fluid replacement Check clotting and fibrinogen IF deterioration continue with fluid resuscitation and give packed cells, cryoprecipitate, fresh frozen plasma and platelets, on the advice of a haematologist.
Observe for:
Anaphylactic reactions; Hypotension Bronchospasm Rash Angio-oedema
When carrying out observations STOP tPA
Continue with O2 and IV fluids Inform medics Give Chlorphenamine 10 milligrams and Hydrocortisone 200 milligrams IV IF SEVERE breathing problems or hypotension give adrenaline IM 500 micrograms repeated if necessary every 5 minutes. NOTE No other IM injection can be given for 24 hours
Observe for:
Neurological deterioration, New headache, vomiting or acute rise in BP
STOP tPA
Inform medics Repeat CT head immediately
Bloods for FBC, fibrinogen and clotting.
Follow up CT Scan at 24 - 36 hours and MUST be done before commencing on aspirin therapy
16
0hrs 15 30 45 1hr 1hr15 1hr30 1hr45 2hr 2hr30 3hr 3hr30 4hr 5hr 6hr 8hr 12hr 16hr 20hr 24hr
TIME (24 HR CLOCK)
eyes open
sleepy but can be fully
awakend by voice
sleepy requiring painful
stimuli to open eyes
No response to stimuli
Normal no speech difficulty
Some speech difficulty
No speech
Can lift up
moves but cannot lift
Cannot move
Can lift up
moves but cannot lift
Cannot move
40
39
38
37
36
35
160
140
120
100
80
60
40
240
220
200
190
180
170
160
150
140
130
120
110
100
90
80
70
50
40
IF FALL OF
1 SQUARE
OR MORE
SINCE 0hrs
SEE OVER
IF TOTAL
FALL OF 2
SQUARES
OR MORE
SINCE 0hrs
SEE OVER
SINCE THROMBOLYSIS
STROKE THROMBOLYSIS OBSERVATION COMPLICATION (STOC) CHART
Blo
od
Pre
ssu
re
PATIENT NAME
Co
nscio
us l
evel
Sp
eech
Heart
Rate
Arm
DATE OF BIRTH / / . DATE TODAY / / . TIME OF THROMBOLYSIS: hrs
Le
g
O2 SATS
IF <94%
SEE OVER
BM (Unless on GKI)
02 % OR L/MIN
IF SBP
<95mmHg
SEE OVER
Te
mp
era
ture
IF SBP >
185mmHg
SEE OVER
IF DBP >
110mmHg
SEE OVER
.
17
Suggested Interventions
NEUROLOGICAL DETERIORATION SINCE THROMBOLYSIS
IF THERE IS A FALL IN CONSCIOUS LEVEL SINCE THROMBOLYSIS BY 1 SQUARE OR MORE OR IF SPEECH + ARM + LEG TOTAL FALLS BY 2 SQUARES OR MORE SINCE THROMBOLYSIS THEN:
STOP ALTEPLASE INFUSION IF IT IS STILL RUNNING CHECK BP AND BM INFORM DOCTOR DOCTOR CONSIDER URGENT CT HEAD CONTACT STROKE PHYSICIAN ON CALL IF UNSURE NIL BY MOUTH UNLESS ABLE TO REASSESS SWALLOW CHECK CLOTTING IF HAEMORRHAGE OR MASSIVE OEDEMA ON CT SCAN THEN CONTACT
NEUROSURGEONS IF HAEMORRHAGE AND CLOTTING ABNORMAL THEN GIVE CRYOPRECIPITATE
HYPER / HYPOTENSION IF SYSTOLIC BP ABOVE 185mm Hg OR IF DIASTOLIC ABOVE 110mm Hg AT ANY TIME THEN:
CONFIRM WITH MANUAL MEASUREMENT (AND CONTINUE WITH MANUAL MEASUREMENTS)
CHECK FOR PAIN AND TREAT CAUSE IF STILL ABOVE RANGE RECHECK IN 5 MINUTES INFORM DOCTOR CONSIDER IV GTN (If GTN started then use GTN protocol and chart)
IF SYSTOLIC BP BELOW 95mmHg THEN:
STOP GTN INFUSION IF RUNNING CHECK FOR EXTERNAL OR INTERNAL BLEEDING (SEE BELOW) RECHECK IN 5 MINUTES IF STILL BELOW RANGE INFORM DOCTOR GIVE IV FLUIDS IF APPROPRIATE URGENT BLOODS FOR FBC / CLOTTING
HYPOXIA IF OXYGEN SATURATION BELOW 94% THEN:
SIT THE PATIENT UP! INCREASE O2 IF APPROPRIATE INFORM DOCTOR
BLEEDING
IF MAJOR BLEEDING STOP ALTEPLASE INFUSION INFORM DOCTOR GIVE IV FLUIDS URGENT BLOODS FOR FBC/CLOTTING
MBH 1680B
18
Intracranial Haemorrhage Algorithm Haemorrhage following initiation of thrombolytic therapy for stroke
Note 1:
Preparations for giving platelets and Cryoprecipitate can be initiated at the first suspicion of haemorrhage so that they would be ready if needed.
Local guidance is that 2 doses of platelets are administered (8 units)
Local guidance is that 2 doses of cryoprecipitate are administered (10 units)
Potential volume is 850 ml so care with patients who have heart failure Note 2:
Recommend any patient with symptomatic haemorrhage is discussed with the Consultant on call to consider whether neurosurgical referral is beneficial
19
20
21
22