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In-plant Training at Square Pharmaceuticals Ltd – Syed Shazzad Ali
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Introduction
In plant training for the professionals is now essential to know in details the
application mode of modern scientific and management issue aiming to familiar
them correctly.
This training is the bridge between the theories and principles with their
practices, in other words between the institution and commercial organization.
SQUARE Pharmaceuticals Limited is committed to ensure between lives through
quality medicine. For this, we selected the SQUARE Pharmaceuticals Limited to
be trained which is already known as one of the tops leading pharmaceutical
company is Bangladesh. I fell proud to take my training in such factory.
All of the employees from top to the bottom of the factory are very much
cooperative and responsive, they help us to understand every operation, simplify
various critical points and make me understand a factory job. we are very much
grateful and our cordial gratitude to them.
In-plant Training at Square Pharmaceuticals Ltd – Syed Shazzad Ali
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In-plant Training at Square Pharmaceuticals Ltd – Syed Shazzad Ali
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Company
Company over view
SQUARE Pharmaceuticals Limited is the largest pharmaceutical company in
Bangladesh and it has been continuously in the 1st position among all national
and multinational companies since 1985. It was established in 1958 and
converted into a public limited company in 1991. The sales turnover of SPL was
more than Taka 5 Billion (US$ 90 million) with about 15% market share (April
2003 – March 2004) having a growth rate of about 16%.
SQUARE today symbolizes a name - a state of mind. But its journey to the growth
and prosperity has been no bed of roses. From the inception in 1958, it has today
burgeoned into one of the top line conglomerates in Bangladesh.
SQUARE Pharmaceuticals Limited, the flagship company, is holding the strong
leadership position in the pharmaceutical industry of Bangladesh since 1985 and
is now on its way to becoming a high performance global player.
Milestones :
1958 : Debut of Square Pharma as a Partnership Firm
1964: Converted into a Private Limited Company
In-plant Training at Square Pharmaceuticals Ltd – Syed Shazzad Ali
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1974: Technical Collaboration with Janssen Pharmaceutical, Belgium, a
subsidiary of Johnson and Johnson International, USA.
1982: Licensing Agreement signed with F. Hoffmann-La Roche Ltd., Switzerland.
1985: Achieved first position in the Pharmaceutical Market of Bangladesh among
all national and multinational companies.
1987: Pioneer in pharmaceutical export from Bangladesh
1991: Converted in to a Public Limited Company
1994: Initial Public Offering of Square Pharmaceutical Shares
1995: Chemical Division of Square Pharmaceuticals Ltd. starts production of
pharmaceutical bulk products (API).
1997: Won the National Export trophy for exporting pharmaceuticals.
1998: Agro-chemicals & Veterinary Products Division of Square Pharma starts
its operation.
2001: US FDA/UK MCA standard new Pharmaceutical factory goes into
operation built under the supervision of Bovis Lend Lease, UK.
2004: Signing of agreement with ROVIPHARM, Vietnam to manufacture and
market SQUARE products under license in Vietnam.
Secured the top position for the best published accounts and report for 2003 in
the manufacturing category for transparency and excellence in corporate
reporting.
In-plant Training at Square Pharmaceuticals Ltd – Syed Shazzad Ali
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2005: New State-of- the-Art SQUARE Cephalosporin Ltd. goes into operation;
built under the supervision of TELSTAR S.A. of Spain as per US FDA/ UK MHRA
requirements.
Their Mission
Their mission is to provide quality & innovative healthcare relief for people,
maintain stringently ethical standard in business operation also ensuring benefit
to the shareholders and other stakeholders.
Their Vision
They see business as a means to the wellbeing of the investors, employees and
the society at large, leading to accretion of wealth through financial and moral
gains as a part of the process of the human civilization.
Their Objective
Their objectives are to conduct transparent business operations within the legal &
social frame work with aims to attain the mission reflected by our vision.
Strengths of SQUARE Pharmaceuticals Ltd
- Strong leadership
- House keeping
- Traditional safety culture
In-plant Training at Square Pharmaceuticals Ltd – Syed Shazzad Ali
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- Good discipline
- Occupational health
Export
Present Markets
Asia: Bhutan, Cambodia, Macau, Malaysia, Myanmar, Nepal, Iraq, Papua New
Guinea, Sri Lanka, Tajikistan, Uzbekistan, Vietnam, Yemen
Africa: Botswana, Benin, Comoros Islands, Gambia, Ghana, Kenya, Libya,
Mauritius, Mozambique, Malawi, Niger, Rwanda, Sierra Leone, Somalia,
Tanzania
Europe: Kosovo, Ukraine
Markets under Exploration
Asia: Hong Kong, Iran, Laos, Maldives, Philippines, Qatar, Saudi Arabia,
Thailand, UAE
Africa: Algeria, Chad, Nigeria, South Africa, Sudan, Ethiopia
Europe: England, Russia
America: Costa Rica
Major Therapeutic Areas
Their marketed product portfolio covers seven core therapeutic areas
Alimentary Preparations
In-plant Training at Square Pharmaceuticals Ltd – Syed Shazzad Ali
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Antiallergy Preparations
Antidiabetic Preparations
Antiparasite Preparations
Bone Calcium Regulator
Cardiovascular Preparations
CNS Preparations
Drugs for Urinary Incontinence
Eye and Ear Preparations
Haematinics
Lipid Modifying Preparations
Local Anesthetics
Mineral Supplements
NSAIDs and Antigout Preparations
Penicillins and Cephalosporins
Quinolone Antibiotics
Respiratory Tract Preparations
Systemic Antifungal, Antiviral and Antiprotozoal Agents
In-plant Training at Square Pharmaceuticals Ltd – Syed Shazzad Ali
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Thyroid Therapy
Topical Preparations
Vitamins and Minerals
Dhaka Unit
The Dhaka Unit is about 50 km away in the north of the capital city. Bovis Lend
Lease, UK designed this plant. This is a state of the art manufacturing facility for
oral solid dosage forms and all facilities have been developed meeting the
requirements of cGMP CFR 21. Dhaka Unit started its operation at the end of
2002.
In the year 2002, the representative of UNICEF, Copenhagen, audited Dhaka
Unit facility and enlisted this plant for their global supply. Besides UNICEF audit,
in 2003, David Begg Associates, an UK based consulting company also audited
this facility and recognized that this plant fulfills the requirement of MHRA (United
Kingdom Medicines and Healthcare Products Regulatory Agency).
Objectives of Dhaka Unit
Meet challenges of globalization
Expand export horizon
Attract contract/ license manufacturing
Benchmark for pharmaceutical industry in Bangladesh
In-plant Training at Square Pharmaceuticals Ltd – Syed Shazzad Ali
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Dhaka Unit is endowed with the following unique features
1. General Production building
Raw material receiving bay with electrocutors to prevent entering insects
Two air conditioned warehouses one is for raw materials and another is
for finished goods and packaging components
In-plant Training at Square Pharmaceuticals Ltd – Syed Shazzad Ali
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Electronic controlled (Interlocked) double-door air locks for material entry
In-plant Training at Square Pharmaceuticals Ltd – Syed Shazzad Ali
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Complete dress change through double change rooms have been
implemented for the personnel with mandatory shower at the first time
entry in a day
All production equipments are modern state of the art from European and
American sources and are cGMP compliance
In-plant Training at Square Pharmaceuticals Ltd – Syed Shazzad Ali
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Down flow sampling and dispensing booths
Granulation suites are completely closed with vacuum loading and transfer
facilities
Material handling is performed by Intermediate Bulk Container (IBC)
system-a closed system for efficient and safe handling of bulk materials
(powder/granules).
In-plant Training at Square Pharmaceuticals Ltd – Syed Shazzad Ali
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IBC cage for powder/granules blending with safety interlock barrier.
In-plant Training at Square Pharmaceuticals Ltd – Syed Shazzad Ali
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IBCs are cleaned through PLC control cleaning cycles with hot, cold and
purified water for effective cleaning
Materials (powder/granules) are discharged by gravity fed discharge
station which is a closed system
In-plant Training at Square Pharmaceuticals Ltd – Syed Shazzad Ali
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2. Secured reject store independent from production building
3. QC laboratory
Independent from production building
In-plant Training at Square Pharmaceuticals Ltd – Syed Shazzad Ali
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All equipments (HPLC, GLC, FTIR, FTNIR, Infrared spectrophotometer,
Atomic absorption etc) are state of the art and from Japanese, European
and American sources.
All
stability studies are performed as per ICH storage guidelines
In-plant Training at Square Pharmaceuticals Ltd – Syed Shazzad Ali
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4. Dedicated Air Handling Units and other building service systems
installed in the mezzanine floor with a focus to prevent cross
contamination.
In-plant Training at Square Pharmaceuticals Ltd – Syed Shazzad Ali
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5. Building Energy Management Systems (BEMS) to control and monitor
temperature, relative humidity and air pressure differential at the
processing area.
In-plant Training at Square Pharmaceuticals Ltd – Syed Shazzad Ali
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6. Central Dust Collector to achieve dust free operation at the point of dust
generation in the processing area
In-plant Training at Square Pharmaceuticals Ltd – Syed Shazzad Ali
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7. Own generation of electricity to ensure uninterrupted power supply
round the clock
8. Purified water meets USP 27 specification. After a series of pretreatment
and softening, softened water is passed through de-ionizer and reverse
osmosis for final purification. Auto sanitization system also exist in the
purified water distribution system.
In-plant Training at Square Pharmaceuticals Ltd – Syed Shazzad Ali
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In-plant Training at Square Pharmaceuticals Ltd – Syed Shazzad Ali
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9. Central and in-house laundry for factory garment cleaning
In-plant Training at Square Pharmaceuticals Ltd – Syed Shazzad Ali
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In-plant Training at Square Pharmaceuticals Ltd – Syed Shazzad Ali
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Orientation And
Department of Square