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Small Cell Lung Cancer
Clinical T-Stage, N0-N3 M0 SCLC
0%
20%
40%
60%
80%
100%
0 2 4 6 8 10YEARS AFTER ENTRY
T1T2T3T4
Deaths / N335 / 470
1158 / 1396484 / 564
883 / 1000
MST21151312
5 Year 29% 15% 11% 10%
From:From: Shepherd FA, Crowley J, Van Houtte P et al. The IASLC lung cancer Shepherd FA, Crowley J, Van Houtte P et al. The IASLC lung cancer staging project: proposals regarding the clinical staging of small cell lung cancer staging project: proposals regarding the clinical staging of small cell lung cancer in the forthcoming (seventh) edition of the tumor, node, metastasis classification in the forthcoming (seventh) edition of the tumor, node, metastasis classification
for lung cancer. J Thorac Oncol 2007; 2: 1067-1077.for lung cancer. J Thorac Oncol 2007; 2: 1067-1077.
Small Cell Lung Cancer
Clinical N-Stage, T1-T4 M0 SCLC
0%
20%
40%
60%
80%
100%
0 2 4 6 8 10YEARS AFTER ENTRY
N0N1N2N3
Deaths / N562 / 750267 / 348
1375 / 1592656 / 740
MST18191412
5 Year 24% 20% 12% 9%
From:From: Shepherd FA, Crowley J, Van Houtte P et al. The IASLC lung cancer Shepherd FA, Crowley J, Van Houtte P et al. The IASLC lung cancer staging project: proposals regarding the clinical staging of small cell lung cancer staging project: proposals regarding the clinical staging of small cell lung cancer in the forthcoming (seventh) edition of the tumor, node, metastasis classification in the forthcoming (seventh) edition of the tumor, node, metastasis classification
for lung cancer. J Thorac Oncol 2007; 2: 1067-1077.for lung cancer. J Thorac Oncol 2007; 2: 1067-1077.
Small Cell Lung Cancer
Survival by Clinical N-Category Within T-CategoryT1-T4, M0 SCLC
cN0M0
0%
20%
40%
60%
80%
100%
0 2 4 6 8 10YEARS AFTER ENTRY
T1T2T3T4
Deaths / N135 / 211246 / 325
79 / 95102 / 119
MST30181713
5 Year 38% 21% 16% 10%
cN3M0
0%
20%
40%
60%
80%
100%
0 2 4 6 8 10YEARS AFTER ENTRY
T1T2T3T4
Deaths / N52 / 56
190 / 212110 / 131304 / 341
MST15121311
5 Year 9% 6% 11% 10%
cN1M0
0%
20%
40%
60%
80%
100%
0 2 4 6 8 10YEARS AFTER ENTRY
T1T2T3T4
Deaths / N36 / 55
132 / 17561 / 7238 / 46
MST33201214
5 Year 38% 20% 11% 13%
cN2M0
0%
20%
40%
60%
80%
100%
0 2 4 6 8 10YEARS AFTER ENTRY
T1T2T3T4
Deaths / N112 / 148590 / 684234 / 266439 / 494
MST16151212
5 Year 19% 13% 10% 9%
From:From: Shepherd FA, Crowley J, Van Houtte P et al. The IASLC lung cancer Shepherd FA, Crowley J, Van Houtte P et al. The IASLC lung cancer staging project: proposals regarding the clinical staging of small cell lung cancer staging project: proposals regarding the clinical staging of small cell lung cancer in the forthcoming (seventh) edition of the tumor, node, metastasis classification in the forthcoming (seventh) edition of the tumor, node, metastasis classification
for lung cancer. J Thorac Oncol 2007; 2: 1067-1077.for lung cancer. J Thorac Oncol 2007; 2: 1067-1077.
Small Cell Lung Cancer
Clinical TNM Stage 6th Edition
0%
20%
40%
60%
80%
100%
0 2 4 6 8 10YEARS AFTER ENTRY
IAIBIIAIIBIIIAIIIB
Deaths / N135 / 211246 / 325
36 / 55211 / 270
997 / 11701235 / 1399
MST301833181412
5 Year 38% 21% 38% 18% 13% 9%
From:From: Shepherd FA, Crowley J, Van Houtte P et al. The IASLC lung cancer Shepherd FA, Crowley J, Van Houtte P et al. The IASLC lung cancer staging project: proposals regarding the clinical staging of small cell lung cancer staging project: proposals regarding the clinical staging of small cell lung cancer in the forthcoming (seventh) edition of the tumor, node, metastasis classification in the forthcoming (seventh) edition of the tumor, node, metastasis classification
for lung cancer. J Thorac Oncol 2007; 2: 1067-1077.for lung cancer. J Thorac Oncol 2007; 2: 1067-1077.
Small Cell Lung Cancer
Pleural Effusion in M0 SCLC
0%
20%
40%
60%
80%
100%
0 2 4 6 8 10YEARS AFTER ENTRY
M0, PE AbsentM0, PE PresentM1
Deaths / N966 / 1113134 / 145
4313 / 4500
MST18127
5 Year 18% 8% 1%
From:From: Shepherd FA, Crowley J, Van Houtte P et al. The IASLC lung cancer Shepherd FA, Crowley J, Van Houtte P et al. The IASLC lung cancer staging project: proposals regarding the clinical staging of small cell lung cancer staging project: proposals regarding the clinical staging of small cell lung cancer in the forthcoming (seventh) edition of the tumor, node, metastasis classification in the forthcoming (seventh) edition of the tumor, node, metastasis classification
for lung cancer. J Thorac Oncol 2007; 2: 1067-1077.for lung cancer. J Thorac Oncol 2007; 2: 1067-1077.
Small Cell Lung Cancer
Pleural Effusion with Cytology in M0 SCLC
0%
20%
40%
60%
80%
100%
0 2 4 6 8 10YEARS AFTER ENTRY
M0, PE AbsentM0, PE Cyt (+)M0, PE Cyt (-)M1
Deaths / N966 / 1113
35 / 4024 / 28
4313 / 4500
MST1812137
5 Year 18% 8% 21% 1%
From:From: Shepherd FA, Crowley J, Van Houtte P et al. The IASLC lung cancer Shepherd FA, Crowley J, Van Houtte P et al. The IASLC lung cancer staging project: proposals regarding the clinical staging of small cell lung cancer staging project: proposals regarding the clinical staging of small cell lung cancer in the forthcoming (seventh) edition of the tumor, node, metastasis classification in the forthcoming (seventh) edition of the tumor, node, metastasis classification
for lung cancer. J Thorac Oncol 2007; 2: 1067-1077.for lung cancer. J Thorac Oncol 2007; 2: 1067-1077.
Small Cell Lung Cancer
TNM Stage 6th and Proposed 7th Edition
0%
20%
40%
60%
80%
100%
0 2 4 6 8 10YEARS AFTER ENTRY
IAIBIIAIIBIIIAIIIBIV
Deaths / N17 / 2514 / 198 / 15
84 / 101332 / 384472 / 533
1400 / 1439
MST3135681713128
5 Year 36% 31% 53% 16% 11% 10% 2%
0%
20%
40%
60%
80%
100%
0 2 4 6 8 10YEARS AFTER ENTRY
IAIBIIAIIBIIIAIIIBIV
Deaths / N17 / 2520 / 27
2 / 883 / 100
326 / 377521 / 587
1358 / 1392
MST3126NR1813128
5 Year 36% 29% 75% 17% 11% 10% 1%
From:From: Shepherd FA, Crowley J, Van Houtte P et al. The IASLC lung cancer Shepherd FA, Crowley J, Van Houtte P et al. The IASLC lung cancer staging project: proposals regarding the clinical staging of small cell lung cancer staging project: proposals regarding the clinical staging of small cell lung cancer in the forthcoming (seventh) edition of the tumor, node, metastasis classification in the forthcoming (seventh) edition of the tumor, node, metastasis classification
for lung cancer. J Thorac Oncol 2007; 2: 1067-1077.for lung cancer. J Thorac Oncol 2007; 2: 1067-1077.
Small Cell Lung Cancer - Validation
Proposed TNM Stage 7th EditionUnited States National Cancer Institute SEER Registries
0%
20%
40%
60%
80%
100%
0 1 2 3 4 5YEARS AFTER DIAGNOSIS
IAIBIIAIIBIIIAIIIBIV
Deaths / N83 / 12780 / 11471 / 10045 / 52
537 / 637545 / 611
3132 / 3243
MST2621151213116
5 Year 22% 19% 25% 13% 10% 9% 1%
From:From: Shepherd FA, Crowley J, Van Houtte P et al. The IASLC lung cancer Shepherd FA, Crowley J, Van Houtte P et al. The IASLC lung cancer staging project: proposals regarding the clinical staging of small cell lung cancer staging project: proposals regarding the clinical staging of small cell lung cancer in the forthcoming (seventh) edition of the tumor, node, metastasis classification in the forthcoming (seventh) edition of the tumor, node, metastasis classification
for lung cancer. J Thorac Oncol 2007; 2: 1067-1077.for lung cancer. J Thorac Oncol 2007; 2: 1067-1077.
