559

IMPETIGO

" XBD=528 XHG=294 YBD=349 YHG=278>THE " XBD=1080 XHG=610 YBD=348 YHG=278>LANCETLO.LYDON: SATURDAY, " XBD=962 XHG=840 YBD=424 YHG=393>MAY " XBD=1029 XHG=995 YBD=429 YHG=393>1, " XBD=1158 XHG=1065 YBD=423 YHG=392>1943

" XBD=196 XHG=155 YBD=591 YHG=557>IT " XBD=242 XHG=211 YBD=590 YHG=556>is " XBD=491 XHG=260 YBD=598 YHG=558>customary " XBD=551 XHG=507 YBD=587 YHG=557>to " XBD=770 XHG=568 YBD=598 YHG=553>recognise " XBD=868 XHG=787 YBD=587 YHG=556>two " XBD=1003 XHG=884 YBD=587 YHG=552>kinds " XBD=1066 XHG=1021 YBD=586 YHG=552>of " XBD=1282 XHG=1078 YBD=597 YHG=552>impetigo," XBD=171 XHG=113 YBD=641 YHG=607>the " XBD=352 XHG=199 YBD=638 YHG=604>bullous " XBD=577 XHG=382 YBD=647 YHG=602>impetigo " XBD=655 XHG=609 YBD=636 YHG=601>of " XBD=847 XHG=682 YBD=645 YHG=600>infancy " XBD=959 XHG=878 YBD=635 YHG=601>and " XBD=1060 XHG=990 YBD=635 YHG=601>the " XBD=1284 XHG=1092 YBD=646 YHG=601>impetigo" XBD=323 XHG=113 YBD=697 YHG=654>contagiosa " XBD=402 XHG=357 YBD=686 YHG=651>of " XBD=630 XHG=432 YBD=684 YHG=651>TILBURY " XBD=767 XHG=662 YBD=684 YHG=650>Fox. " XBD=989 XHG=823 YBD=684 YHG=648>Bullous " XBD=1215 XHG=1023 YBD=694 YHG=650>impetigo " XBD=1284 XHG=1250 YBD=683 YHG=650>is" XBD=187 XHG=111 YBD=737 YHG=713>now " XBD=397 XHG=200 YBD=745 YHG=699>generally " XBD=606 XHG=413 YBD=744 YHG=699>accepted " XBD=667 XHG=623 YBD=732 YHG=710>as " XBD=707 XHG=683 YBD=733 YHG=710>a " XBD=1046 XHG=725 YBD=743 YHG=698>staphylococcal " XBD=1281 XHG=1062 YBD=739 YHG=697>infection ;" XBD=137 XHG=110 YBD=786 YHG=752>it " XBD=180 XHG=149 YBD=784 YHG=751>is " XBD=331 XHG=196 YBD=794 YHG=748>highly " XBD=585 XHG=348 YBD=793 YHG=748>contagious " XBD=684 XHG=603 YBD=781 YHG=748>and " XBD=775 XHG=701 YBD=781 YHG=747>has " XBD=918 XHG=793 YBD=792 YHG=746>lately " XBD=1037 XHG=936 YBD=781 YHG=747>been " XBD=1164 XHG=1054 YBD=781 YHG=758>more " XBD=1283 XHG=1182 YBD=781 YHG=747>than" XBD=307 XHG=110 YBD=842 YHG=796>ordinarily " XBD=549 XHG=338 YBD=842 YHG=796>prevalent " XBD=625 XHG=582 YBD=829 YHG=796>in " XBD=864 XHG=658 YBD=837 YHG=796>nurseries, " XBD=1151 XHG=899 YBD=840 YHG=795>fortunately " XBD=1225 XHG=1183 YBD=830 YHG=796>in " XBD=1282 XHG=1258 YBD=830 YHG=808>a" XBD=191 XHG=109 YBD=882 YHG=846>mild " XBD=328 XHG=215 YBD=880 YHG=845>form. " XBD=590 XHG=381 YBD=889 YHG=844>Although " XBD=837 XHG=617 YBD=884 YHG=844>ALMQUIST " XBD=1092 XHG=862 YBD=890 YHG=845>recognised " XBD=1280 XHG=1119 YBD=879 YHG=845>distinc-" XBD=177 XHG=106 YBD=929 YHG=895>tive " XBD=361 XHG=196 YBD=928 YHG=893>cultural " XBD=609 XHG=382 YBD=927 YHG=893>characters " XBD=671 XHG=629 YBD=927 YHG=894>in " XBD=761 XHG=690 YBD=927 YHG=893>the " XBD=916 XHG=782 YBD=928 YHG=893>causal " XBD=1280 XHG=937 YBD=939 YHG=892>staphylococcus," XBD=222 XHG=106 YBD=978 YHG=944>recent " XBD=353 XHG=245 YBD=977 YHG=942>work " XBD=450 XHG=375 YBD=976 YHG=942>has " XBD=597 XHG=473 YBD=976 YHG=941>failed " XBD=665 XHG=621 YBD=977 YHG=945>to " XBD=855 XHG=691 YBD=977 YHG=942>confirm " XBD=941 XHG=878 YBD=976 YHG=942>his " XBD=1115 XHG=966 YBD=984 YHG=942>claims, " XBD=1224 XHG=1141 YBD=977 YHG=942>and " XBD=1282 XHG=1247 YBD=977 YHG=943>it" XBD=214 XHG=107 YBD=1027 YHG=1002>seems " XBD=346 XHG=254 YBD=1026 YHG=991>that " XBD=466 XHG=395 YBD=1025 YHG=990>the " XBD=624 XHG=507 YBD=1025 YHG=990>usual " XBD=813 XHG=675 YBD=1026 YHG=1002>source " XBD=900 XHG=855 YBD=1025 YHG=991>of " XBD=1131 XHG=938 YBD=1026 YHG=991>infection " XBD=1206 XHG=1172 YBD=1026 YHG=992>is " XBD=1280 XHG=1256 YBD=1026 YHG=1003>a" XBD=407 XHG=106 YBD=1085 YHG=1038>staphylococcal " XBD=529 XHG=438 YBD=1073 YHG=1040>skin " XBD=683 XHG=558 YBD=1074 YHG=1040>lesion " XBD=756 XHG=712 YBD=1074 YHG=1041>in " XBD=943 XHG=785 YBD=1074 YHG=1040>mother " XBD=1016 XHG=973 YBD=1075 YHG=1052>or " XBD=1277 XHG=1046 YBD=1075 YHG=1041>attendant." XBD=175 XHG=105 YBD=1124 YHG=1088>The " XBD=303 XHG=190 YBD=1122 YHG=1098>cause " XBD=360 XHG=315 YBD=1122 YHG=1087>of " XBD=566 XHG=370 YBD=1133 YHG=1088>impetigo " XBD=825 XHG=580 YBD=1134 YHG=1089>contagiosa, " XBD=966 XHG=837 YBD=1123 YHG=1089>which " XBD=1015 XHG=982 YBD=1123 YHG=1090>is " XBD=1279 XHG=1031 YBD=1124 YHG=1093>commonest" XBD=140 XHG=105 YBD=1172 YHG=1139>at " XBD=287 XHG=159 YBD=1171 YHG=1136>school " XBD=394 XHG=310 YBD=1181 YHG=1148>age, " XBD=453 XHG=418 YBD=1171 YHG=1137>is " XBD=588 XHG=476 YBD=1173 YHG=1149>more " XBD=814 XHG=612 YBD=1172 YHG=1137>doubtful. " XBD=903 XHG=866 YBD=1172 YHG=1137>A " XBD=1062 XHG=926 YBD=1172 YHG=1138>mixed " XBD=1279 XHG=1085 YBD=1173 YHG=1138>infection" XBD=186 XHG=104 YBD=1219 YHG=1185>with " XBD=438 XHG=212 YBD=1230 YHG=1184>heemolytic " XBD=731 XHG=467 YBD=1231 YHG=1187>streptococci " XBD=840 XHG=759 YBD=1221 YHG=1186>and " XBD=1165 XHG=868 YBD=1232 YHG=1186>staphylococci " XBD=1226 XHG=1192 YBD=1221 YHG=1187>is " XBD=1279 XHG=1254 YBD=1221 YHG=1199>a" XBD=270 XHG=105 YBD=1268 YHG=1245>common " XBD=441 XHG=288 YBD=1280 YHG=1234>finding " XBD=504 XHG=460 YBD=1268 YHG=1235>in " XBD=593 XHG=522 YBD=1269 YHG=1236>the " XBD=791 XHG=614 YBD=1281 YHG=1235>crusting " XBD=954 XHG=810 YBD=1270 YHG=1235>lesions " XBD=1019 XHG=974 YBD=1270 YHG=1235>of " XBD=1143 XHG=1034 YBD=1270 YHG=1247>some " XBD=1277 XHG=1163 YBD=1280 YHG=1235>days’" XBD=298 XHG=104 YBD=1324 YHG=1282>duration ; " XBD=430 XHG=348 YBD=1317 YHG=1284>and " XBD=787 XHG=463 YBD=1330 YHG=1284>bacteriological " XBD=984 XHG=820 YBD=1329 YHG=1284>opinion " XBD=1089 XHG=1015 YBD=1318 YHG=1284>has " XBD=1176 XHG=1123 YBD=1318 YHG=1296>on " XBD=1278 XHG=1207 YBD=1318 YHG=1284>the" XBD=212 XHG=104 YBD=1365 YHG=1330>whole " XBD=423 XHG=228 YBD=1366 YHG=1331>favoured |>" XBD=724 XHG=442 YBD=1377 YHG=1332>Streptococcus " XBD=928 XHG=739 YBD=1377 YHG=1344>pyogenes " XBD=992 XHG=948 YBD=1368 YHG=1345>as " XBD=1080 XHG=1010 YBD=1367 YHG=1333>the " XBD=1279 XHG=1099 YBD=1378 YHG=1333>primary" XBD=275 XHG=102 YBD=1426 YHG=1379>infecting " XBD=514 XHG=301 YBD=1426 YHG=1381>organism." XBD=249 XHG=143 YBD=1464 YHG=1428>Since " XBD=356 XHG=284 YBD=1464 YHG=1430>the " XBD=595 XHG=395 YBD=1465 YHG=1431>outbreak " XBD=679 XHG=634 YBD=1465 YHG=1431>of " XBD=795 XHG=714 YBD=1466 YHG=1443>war " XBD=1026 XHG=833 YBD=1476 YHG=1431>impetigo " XBD=1137 XHG=1064 YBD=1465 YHG=1431>has " XBD=1278 XHG=1177 YBD=1465 YHG=1431>been" XBD=349 XHG=101 YBD=1513 YHG=1478>troublesome " XBD=528 XHG=380 YBD=1526 YHG=1491>among " XBD=710 XHG=559 YBD=1526 YHG=1483>troops, " XBD=826 XHG=744 YBD=1514 YHG=1480>and " XBD=1023 XHG=855 YBD=1514 YHG=1480>interest " XBD=1127 XHG=1053 YBD=1514 YHG=1480>has " XBD=1278 XHG=1159 YBD=1525 YHG=1480>again" XBD=185 XHG=101 YBD=1561 YHG=1527>been " XBD=364 XHG=202 YBD=1562 YHG=1527>focused " XBD=438 XHG=385 YBD=1563 YHG=1540>on " XBD=513 XHG=458 YBD=1563 YHG=1529>its " XBD=723 XHG=535 YBD=1574 YHG=1528>aetiology " XBD=826 XHG=744 YBD=1563 YHG=1529>and " XBD=1078 XHG=845 YBD=1563 YHG=1531>treatment. " XBD=1184 XHG=1133 YBD=1563 YHG=1529>In " XBD=1278 XHG=1204 YBD=1563 YHG=1540>our" XBD=257 XHG=100 YBD=1621 YHG=1580>present. " XBD=388 XHG=282 YBD=1611 YHG=1578>issue " XBD=514 XHG=431 YBD=1612 YHG=1580>two " XBD=833 XHG=559 YBD=1623 YHG=1578>independent " XBD=1023 XHG=874 YBD=1623 YHG=1589>groups " XBD=1112 XHG=1066 YBD=1612 YHG=1576>of " XBD=1278 XHG=1148 YBD=1622 YHG=1577>Army" XBD=361 XHG=99 YBD=1671 YHG=1625>investigators " XBD=483 XHG=392 YBD=1671 YHG=1626>give " XBD=682 XHG=519 YBD=1661 YHG=1637>reasons " XBD=774 XHG=711 YBD=1661 YHG=1625>for " XBD=1044 XHG=807 YBD=1671 YHG=1626>concluding " XBD=1172 XHG=1077 YBD=1661 YHG=1626>that " XBD=1275 XHG=1199 YBD=1661 YHG=1626>im-" XBD=214 XHG=97 YBD=1720 YHG=1674>petigo " XBD=279 XHG=237 YBD=1708 YHG=1675>in " XBD=375 XHG=304 YBD=1709 YHG=1675>the " XBD=517 XHG=400 YBD=1709 YHG=1674>adult " XBD=576 XHG=542 YBD=1710 YHG=1676>is " XBD=680 XHG=602 YBD=1709 YHG=1675>due " XBD=751 XHG=706 YBD=1710 YHG=1678>to |>" XBD=1096 XHG=776 YBD=1720 YHG=1675>Staphylococcu8 |>" XBD=1274 XHG=1120 YBD=1710 YHG=1686>aureU8." XBD=177 XHG=97 YBD=1757 YHG=1722>This " XBD=407 XHG=210 YBD=1768 YHG=1724>organism " XBD=525 XHG=444 YBD=1758 YHG=1735>was " XBD=774 XHG=561 YBD=1759 YHG=1725>recovered " XBD=913 XHG=809 YBD=1758 YHG=1723>from " XBD=1019 XHG=948 YBD=1757 YHG=1724>the " XBD=1198 XHG=1054 YBD=1758 YHG=1723>lesions " XBD=1279 XHG=1235 YBD=1758 YHG=1723>of" XBD=207 XHG=98 YBD=1807 YHG=1772>about " XBD=325 XHG=228 YBD=1818 YHG=1771>95% " XBD=394 XHG=349 YBD=1807 YHG=1772>of " XBD=517 XHG=411 YBD=1807 YHG=1773>their " XBD=661 XHG=540 YBD=1814 YHG=1784>cases, " XBD=860 XHG=685 YBD=1807 YHG=1773>whereas " XBD=958 XHG=880 YBD=1807 YHG=1773>Str. " XBD=1171 XHG=978 YBD=1817 YHG=1783>pyogenes " XBD=1274 XHG=1192 YBD=1807 YHG=1784>was" XBD=239 XHG=98 YBD=1866 YHG=1824>present " XBD=305 XHG=262 YBD=1855 YHG=1821>in " XBD=427 XHG=331 YBD=1866 YHG=1820>only " XBD=502 XHG=453 YBD=1856 YHG=1822>25 " XBD=574 XHG=529 YBD=1856 YHG=1825>to " XBD=713 XHG=601 YBD=1866 YHG=1820>38%. " XBD=883 XHG=768 YBD=1855 YHG=1822>Even " XBD=1018 XHG=907 YBD=1856 YHG=1833>more " XBD=1273 XHG=1045 YBD=1866 YHG=1821>significant" XBD=164 XHG=97 YBD=1905 YHG=1881>was " XBD=250 XHG=182 YBD=1904 YHG=1870>the " XBD=417 XHG=270 YBD=1904 YHG=1869>almost " XBD=630 XHG=440 YBD=1904 YHG=1873>constant " XBD=886 XHG=652 YBD=1905 YHG=1881>occurrence " XBD=954 XHG=908 YBD=1904 YHG=1869>of " XBD=1107 XHG=970 YBD=1914 YHG=1870>Staph. " XBD=1273 XHG=1130 YBD=1904 YHG=1881>aureus" XBD=129 XHG=97 YBD=1953 YHG=1919>in " XBD=244 XHG=151 YBD=1964 YHG=1930>pure " XBD=425 XHG=270 YBD=1953 YHG=1918>culture " XBD=496 XHG=453 YBD=1954 YHG=1920>in " XBD=593 XHG=521 YBD=1953 YHG=1919>the " XBD=720 XHG=620 YBD=1953 YHG=1918>fluid " XBD=792 XHG=747 YBD=1953 YHG=1918>of " XBD=885 XHG=814 YBD=1953 YHG=1919>the " XBD=1092 XHG=911 YBD=1964 YHG=1919>primary " XBD=1270 XHG=1118 YBD=1960 YHG=1918>blister," XBD=194 XHG=97 YBD=2002 YHG=1967>while " XBD=285 XHG=216 YBD=2002 YHG=1968>the " XBD=539 XHG=308 YBD=2013 YHG=1967>haemolytic " XBD=874 XHG=565 YBD=2012 YHG=1971>streptococcus, " XBD=999 XHG=900 YBD=2013 YHG=1979>very " XBD=1110 XHG=1021 YBD=2001 YHG=1978>rare " XBD=1177 XHG=1133 YBD=2001 YHG=1967>in " XBD=1271 XHG=1200 YBD=2002 YHG=1968>the" XBD=189 XHG=96 YBD=2062 YHG=2016>early " XBD=336 XHG=214 YBD=2057 YHG=2015>bulla, " XBD=528 XHG=366 YBD=2051 YHG=2016>showed " XBD=580 XHG=556 YBD=2050 YHG=2028>a " XBD=731 XHG=608 YBD=2061 YHG=2016>rising " XBD=963 XHG=758 YBD=2050 YHG=2016>incidence " XBD=1034 XHG=990 YBD=2050 YHG=2016>in " XBD=1132 XHG=1061 YBD=2050 YHG=2016>the " XBD=1272 XHG=1160 YBD=2051 YHG=2016>older" XBD=253 XHG=97 YBD=2110 YHG=2065>crusting " XBD=432 XHG=275 YBD=2099 YHG=2065>lesions. " XBD=544 XHG=488 YBD=2099 YHG=2065>As " XBD=736 XHG=568 YBD=2099 YHG=2064>BIGGER " XBD=840 XHG=758 YBD=2099 YHG=2065>and " XBD=1073 XHG=862 YBD=2099 YHG=2064>HODGSON " XBD=1268 XHG=1097 YBD=2106 YHG=2065>remark," XBD=152 XHG=95 YBD=2149 YHG=2115>the " XBD=339 XHG=168 YBD=2148 YHG=2114>increase " XBD=395 XHG=353 YBD=2148 YHG=2114>in " XBD=699 XHG=407 YBD=2159 YHG=2113>streptococcal " XBD=910 XHG=717 YBD=2148 YHG=2112>infection " XBD=1023 XHG=925 YBD=2148 YHG=2114>with " XBD=1270 XHG=1043 YBD=2159 YHG=2114>advancing" XBD=154 XHG=96 YBD=2209 YHG=2174>age " XBD=211 XHG=169 YBD=2197 YHG=2163>of " XBD=291 XHG=222 YBD=2198 YHG=2163>the " XBD=434 XHG=307 YBD=2196 YHG=2162>lesion " XBD=533 XHG=451 YBD=2196 YHG=2173>was " XBD=764 XHG=550 YBD=2207 YHG=2161>strikingly " XBD=930 XHG=780 YBD=2196 YHG=2162>similar " XBD=990 XHG=946 YBD=2196 YHG=2165>to " XBD=1101 XHG=1006 YBD=2196 YHG=2162>that " XBD=1210 XHG=1117 YBD=2196 YHG=2174>seen " XBD=1268 XHG=1225 YBD=2197 YHG=2163>in" XBD=199 XHG=95 YBD=2246 YHG=2212>burns " XBD=265 XHG=223 YBD=2246 YHG=2222>or " XBD=395 XHG=291 YBD=2257 YHG=2223>open " XBD=599 XHG=417 YBD=2252 YHG=2211>wounds, " XBD=708 XHG=626 YBD=2245 YHG=2211>and " XBD=844 XHG=731 YBD=2245 YHG=2210>there " XBD=994 XHG=869 YBD=2245 YHG=2222>seems " XBD=1062 XHG=1018 YBD=2245 YHG=2213>to " XBD=1137 XHG=1088 YBD=2245 YHG=2210>be " XBD=1267 XHG=1160 YBD=2245 YHG=2211>little" XBD=205 XHG=95 YBD=2296 YHG=2261>doubt " XBD=326 XHG=233 YBD=2295 YHG=2260>that " XBD=398 XHG=355 YBD=2293 YHG=2259>in " XBD=533 XHG=427 YBD=2294 YHG=2259>their " XBD=673 XHG=564 YBD=2294 YHG=2270>cases " XBD=774 XHG=703 YBD=2293 YHG=2259>the " XBD=1101 XHG=805 YBD=2305 YHG=2262>streptococcus " XBD=1211 XHG=1130 YBD=2294 YHG=2271>was " XBD=1266 XHG=1242 YBD=2294 YHG=2272>a" XBD=293 XHG=94 YBD=2354 YHG=2309>secondary " XBD=497 XHG=317 YBD=2343 YHG=2308>invader. " XBD=678 XHG=551 YBD=2342 YHG=2308>These " XBD=875 XHG=703 YBD=2343 YHG=2308>workers " XBD=1051 XHG=899 YBD=2353 YHG=2307>largely " XBD=1196 XHG=1073 YBD=2343 YHG=2307>failed " XBD=1265 XHG=1220 YBD=2342 YHG=2311>to" XBD=289 XHG=92 YBD=2404 YHG=2359>reproduce " XBD=480 XHG=311 YBD=2402 YHG=2357>typical - " XBD=682 XHG=489 YBD=2402 YHG=2357>impetigo " XBD=763 XHG=706 YBD=2401 YHG=2357>by " XBD=1032 XHG=784 YBD=2391 YHG=2356>inoculation " XBD=1102 XHG=1055 YBD=2391 YHG=2356>of " XBD=1264 XHG=1120 YBD=2391 YHG=2357>vesicle" XBD=175 XHG=92 YBD=2442 YHG=2407>fluid " XBD=237 XHG=195 YBD=2442 YHG=2418>or " XBD=583 XHG=259 YBD=2451 YHG=2405>staphylococcal " XBD=760 XHG=605 YBD=2440 YHG=2405>culture " XBD=835 XHG=782 YBD=2439 YHG=2416>on " XBD=926 XHG=856 YBD=2439 YHG=2405>the " XBD=1039 XHG=949 YBD=2439 YHG=2405>skin " XBD=1106 XHG=1060 YBD=2439 YHG=2405>of " XBD=1262 XHG=1121 YBD=2440 YHG=2405>volun-" XBD=189 XHG=92 YBD=2490 YHG=2458>teers. " XBD=446 XHG=242 YBD=2490 YHG=2455>SHEEHAN " XBD=571 XHG=489 YBD=2489 YHG=2455>and " XBD=899 XHG=613 YBD=2495 YHG=2454>FEROUSSON, " XBD=1119 XHG=921 YBD=2495 YHG=2454>however, " XBD=1264 XHG=1162 YBD=2489 YHG=2466>were" XBD=183 XHG=91 YBD=2539 YHG=2516>more " XBD=434 XHG=210 YBD=2545 YHG=2503>successful, " XBD=535 XHG=464 YBD=2537 YHG=2503>the " XBD=655 XHG=565 YBD=2537 YHG=2503>best " XBD=1049 XHG=682 YBD=2548 YHG=2502>results-varying " XBD=1181 XHG=1076 YBD=2538 YHG=2502>from " XBD=1264 XHG=1210 YBD=2537 YHG=2515>an" XBD=255 XHG=90 YBD=2597 YHG=2553>aborting " XBD=426 XHG=281 YBD=2587 YHG=2552>vesicle " XBD=497 XHG=452 YBD=2586 YHG=2555>to " XBD=599 XHG=524 YBD=2586 YHG=2551>full " XBD=989 XHG=625 YBD=2597 YHG=2551>impetigo-being " XBD=1180 XHG=1016 YBD=2586 YHG=2552>secured " XBD=1264 XHG=1207 YBD=2597 YHG=2552>by" XBD=242 XHG=89 YBD=2645 YHG=2601>rubbing |>" XBD=556 XHG=275 YBD=2635 YHG=2600>vesicle fluid " XBD=678 XHG=591 YBD=2634 YHG=2600>into " XBD=895 XHG=715 YBD=2634 YHG=2600>scarified " XBD=1044 XHG=931 YBD=2634 YHG=2611>areas " XBD=1125 XHG=1080 YBD=2634 YHG=2600>of " XBD=1259 XHG=1156 YBD=2635 YHG=2600>skin." XBD=227 XHG=89 YBD=2684 YHG=2648>Similar " XBD=386 XHG=243 YBD=2684 YHG=2648>lesions " XBD=505 XHG=403 YBD=2683 YHG=2660>were " XBD=729 XHG=523 YBD=2690 YHG=2649>obtained, " XBD=903 XHG=748 YBD=2694 YHG=2648>though " XBD=996 XHG=920 YBD=2683 YHG=2648>less " XBD=1260 XHG=1015 YBD=2693 YHG=2648>constantly," XBD=170 XHG=89 YBD=2732 YHG=2698>with " XBD=371 XHG=199 YBD=2732 YHG=2696>cultures " XBD=449 XHG=403 YBD=2732 YHG=2697>of " XBD=615 XHG=476 YBD=2742 YHG=2697>Staph. |>" XBD=802 XHG=648 YBD=2738 YHG=2708>aureus, " XBD=911 XHG=836 YBD=2732 YHG=2698>but " XBD=1189 XHG=941 YBD=2732 YHG=2696>inoculation " XBD=1266 XHG=1221 YBD=2731 YHG=2697>of" XBD=149 XHG=89 YBD=2780 YHG=2746>Str. " XBD=348 XHG=163 YBD=2790 YHG=2757>pyogenes " XBD=448 XHG=365 YBD=2780 YHG=2746>and " XBD=610 XHG=472 YBD=2790 YHG=2746>Staph. " XBD=740 XHG=630 YBD=2780 YHG=2745>albu8 " XBD=834 XHG=763 YBD=2780 YHG=2746>did " XBD=931 XHG=858 YBD=2780 YHG=2748>not " XBD=1166 XHG=948 YBD=2791 YHG=2746>reproduce " XBD=1260 XHG=1190 YBD=2780 YHG=2746>the" XBD=232 XHG=89 YBD=2828 YHG=2793>disease. " XBD=441 XHG=285 YBD=2829 YHG=2793>Strains " XBD=515 XHG=469 YBD=2829 YHG=2794>of " XBD=675 XHG=538 YBD=2838 YHG=2794>Staph. |>" XBD=846 XHG=704 YBD=2829 YHG=2804>aureus " XBD=989 XHG=874 YBD=2829 YHG=2794>other " XBD=1118 XHG=1014 YBD=2828 YHG=2794>than " XBD=1260 XHG=1143 YBD=2828 YHG=2794>those" XBD=236 XHG=87 YBD=2876 YHG=2841>isolated " XBD=363 XHG=260 YBD=2877 YHG=2841>from " XBD=501 XHG=391 YBD=2877 YHG=2854>cases " XBD=573 XHG=528 YBD=2877 YHG=2842>of " XBD=786 XHG=594 YBD=2889 YHG=2842>impetigo " XBD=913 XHG=813 YBD=2877 YHG=2854>were " XBD=1012 XHG=939 YBD=2877 YHG=2846>not " XBD=1183 XHG=1037 YBD=2877 YHG=2843>tested." XBD=242 XHG=126 YBD=2924 YHG=2890>These " XBD=432 XHG=259 YBD=2936 YHG=2891>findings " XBD=581 XHG=450 YBD=2926 YHG=2892>afford " XBD=738 XHG=598 YBD=2936 YHG=2894>pretty " XBD=980 XHG=756 YBD=2926 YHG=2891>conclusive " XBD=1117 XHG=997 YBD=2937 YHG=2891>proof " XBD=1177 XHG=1130 YBD=2925 YHG=2891>of " XBD=1260 XHG=1190 YBD=2925 YHG=2891>the" XBD=387 XHG=87 YBD=2982 YHG=2938>staphylococcal " XBD=544 XHG=413 YBD=2985 YHG=2940>origin " XBD=615 XHG=570 YBD=2974 YHG=2940>of " XBD=829 XHG=635 YBD=2986 YHG=2940>impetigo " XBD=898 XHG=854 YBD=2974 YHG=2952>as " XBD=1017 XHG=924 YBD=2974 YHG=2951>seen " XBD=1084 XHG=1041 YBD=2974 YHG=2940>in " XBD=1257 XHG=1110 YBD=2981 YHG=2939>adults," XBD=151 XHG=86 YBD=3020 YHG=2986>and " XBD=234 XHG=171 YBD=3020 YHG=2997>are " XBD=498 XHG=256 YBD=3033 YHG=2988>apparently " XBD=564 XHG=519 YBD=3022 YHG=2992>at " XBD=772 XHG=585 YBD=3024 YHG=2989>variance " XBD=891 XHG=794 YBD=3023 YHG=2989>with " XBD=984 XHG=913 YBD=3022 YHG=2988>the " XBD=1194 XHG=1005 YBD=3023 YHG=2988>evidence " XBD=1259 XHG=1215 YBD=3022 YHG=2989>in" XBD=208 XHG=85 YBD=3068 YHG=3032>favour " XBD=296 XHG=252 YBD=3069 YHG=3035>of " XBD=361 XHG=338 YBD=3069 YHG=3048>a " XBD=587 XHG=406 YBD=3081 YHG=3037>primary " XBD=920 XHG=632 YBD=3082 YHG=3036>streptococcal " XBD=1169 XHG=964 YBD=3071 YHG=3037>infection. " XBD=1259 XHG=1222 YBD=3071 YHG=3037>A" XBD=236 XHG=85 YBD=3124 YHG=3082>possible " XBD=423 XHG=248 YBD=3118 YHG=3083>solution " XBD=480 XHG=436 YBD=3119 YHG=3088>to " XBD=577 XHG=494 YBD=3119 YHG=3085>this " XBD=753 XHG=592 YBD=3120 YHG=3086>conflict " XBD=799 XHG=764 YBD=3120 YHG=3087>is " XBD=961 XHG=813 YBD=3120 YHG=3086>offered " XBD=1030 XHG=973 YBD=3129 YHG=3085>by |>|>|>" XBD=1257 XHG=1042 YBD=3126 YHG=3085>ErSTBlN/" XBD=156 XHG=85 YBD=3163 YHG=3129>who " XBD=345 XHG=187 YBD=3165 YHG=3129>learned " XBD=422 XHG=379 YBD=3166 YHG=3133>in " XBD=529 XHG=457 YBD=3167 YHG=3133>the " XBD=681 XHG=567 YBD=3167 YHG=3133>clinic " XBD=762 XHG=717 YBD=3167 YHG=3133>of " XBD=1139 XHG=793 YBD=3168 YHG=3135>LEW ANDOWSKY " XBD=1255 XHG=1173 YBD=3168 YHG=3133>and" XBD=313 XHG=84 YBD=3212 YHG=3174>JADASSOHN " XBD=383 XHG=340 YBD=3213 YHG=3179>in " XBD=580 XHG=410 YBD=3215 YHG=3180>Breslau " XBD=700 XHG=607 YBD=3215 YHG=3182>that " XBD=840 XHG=727 YBD=3215 YHG=3182>there " XBD=934 XHG=867 YBD=3215 YHG=3193>are " XBD=1042 XHG=961 YBD=3215 YHG=3184>two " XBD=1257 XHG=1070 YBD=3215 YHG=3182>varieties" XBD=119 XHG=84 YBD=3257 YHG=3223>of " XBD=321 XHG=127 YBD=3271 YHG=3224>impetigo, " XBD=469 XHG=339 YBD=3261 YHG=3227>which " XBD=584 XHG=485 YBD=3262 YHG=3229>with " XBD=625 XHG=601 YBD=3262 YHG=3240>a " XBD=745 XHG=639 YBD=3262 YHG=3228>little " XBD=991 XHG=761 YBD=3273 YHG=3229>experience " XBD=1083 XHG=1008 YBD=3263 YHG=3240>can " XBD=1257 XHG=1098 YBD=3273 YHG=3229>usually" XBD=121 XHG=84 YBD=3305 YHG=3270>be " XBD=448 XHG=147 YBD=3310 YHG=3272>differentiated. " XBD=803 XHG=503 YBD=3321 YHG=3276>Streptococcal " XBD=1037 XHG=831 YBD=3322 YHG=3277>impetigo, " XBD=1118 XHG=1067 YBD=3311 YHG=3277>he " XBD=1253 XHG=1147 YBD=3322 YHG=3288>says," XBD=107 XHG=83 YBD=3353 YHG=3319>is " XBD=419 XHG=137 YBD=3357 YHG=3321>characterised " XBD=512 XHG=455 YBD=3368 YHG=3324>by " XBD=601 XHG=547 YBD=3358 YHG=3336>an " XBD=876 XHG=636 YBD=3362 YHG=3328>evanescent " XBD=1106 XHG=910 YBD=3359 YHG=3325>vesicular " XBD=1253 XHG=1140 YBD=3369 YHG=3329>stage" XBD=242 XHG=81 YBD=3404 YHG=3367>followed " XBD=335 XHG=277 YBD=3406 YHG=3370>bv " XBD=484 XHG=370 YBD=3405 YHG=3372>thick " XBD=712 XHG=523 YBD=3405 YHG=3372>stuck-on " XBD=1086 XHG=749 YBD=3406 YHG=3372>honev-coloured " XBD=1253 XHG=1124 YBD=3406 YHG=3376>crusts

1. Epstein, S. Arch. Derm. Syph. 1940, 42, 840.

" XBD=1452 XHG=1354 YBD=237 YHG=203>with " XBD=1552 XHG=1496 YBD=237 YHG=214>an " XBD=1901 XHG=1597 YBD=247 YHG=202>erythematous " XBD=2098 XHG=1945 YBD=236 YHG=202>sodden " XBD=2240 XHG=2141 YBD=236 YHG=212>zone " XBD=2442 XHG=2285 YBD=235 YHG=201>around " XBD=2558 XHG=2484 YBD=236 YHG=202>the" XBD=1504 XHG=1352 YBD=292 YHG=251>lesion ; " XBD=1588 XHG=1554 YBD=285 YHG=251>it " XBD=1653 XHG=1619 YBD=285 YHG=251>is " XBD=1836 XHG=1684 YBD=296 YHG=250>mostly " XBD=1962 XHG=1868 YBD=285 YHG=262>seen " XBD=2035 XHG=1992 YBD=284 YHG=250>in " XBD=2247 XHG=2067 YBD=284 YHG=249>children " XBD=2362 XHG=2279 YBD=284 YHG=250>and " XBD=2468 XHG=2392 YBD=284 YHG=249>has " XBD=2557 XHG=2499 YBD=285 YHG=250>its" XBD=1578 XHG=1351 YBD=334 YHG=302>maximum " XBD=1803 XHG=1598 YBD=334 YHG=299>incidence " XBD=1864 XHG=1823 YBD=333 YHG=300>in " XBD=1957 XHG=1887 YBD=333 YHG=299>the " XBD=2163 XHG=1978 YBD=333 YHG=302>autumn. " XBD=2554 XHG=2218 YBD=343 YHG=298>Staphylococcal" XBD=1545 XHG=1350 YBD=393 YHG=348>impetigo " XBD=1597 XHG=1563 YBD=382 YHG=349>is " XBD=1835 XHG=1615 YBD=393 YHG=347>primarily, " XBD=1938 XHG=1856 YBD=382 YHG=348>and " XBD=2066 XHG=1955 YBD=382 YHG=358>more " XBD=2357 XHG=2084 YBD=392 YHG=346>persistently, |>" XBD=2554 XHG=2378 YBD=388 YHG=347>bullops," XBD=1462 XHG=1350 YBD=437 YHG=396>with, " XBD=1603 XHG=1488 YBD=437 YHG=396>later, " XBD=1721 XHG=1629 YBD=430 YHG=396>thin " XBD=1817 XHG=1743 YBD=431 YHG=396>flat " XBD=2104 XHG=1841 YBD=431 YHG=395>varnish-like " XBD=2258 XHG=2128 YBD=430 YHG=398>crusts " XBD=2365 XHG=2283 YBD=430 YHG=395>and " XBD=2415 XHG=2389 YBD=430 YHG=407>a " XBD=2553 XHG=2440 YBD=430 YHG=395>clean" XBD=1469 XHG=1350 YBD=486 YHG=445>base ; " XBD=1577 XHG=1500 YBD=479 YHG=445>but " XBD=1661 XHG=1591 YBD=479 YHG=445>the " XBD=1995 XHG=1673 YBD=490 YHG=444>staphylococcal " XBD=2135 XHG=2009 YBD=480 YHG=445>lesion " XBD=2246 XHG=2149 YBD=489 YHG=455>may " XBD=2317 XHG=2260 YBD=491 YHG=444>by " XBD=2553 XHG=2329 YBD=489 YHG=444>secondary" XBD=1545 XHG=1349 YBD=527 YHG=492>infection " XBD=1727 XHG=1571 YBD=527 YHG=504>assume " XBD=1863 XHG=1753 YBD=528 YHG=505>more " XBD=1936 XHG=1890 YBD=528 YHG=494>of " XBD=2026 XHG=1956 YBD=528 YHG=494>the " XBD=2280 XHG=2053 YBD=529 YHG=494>characters " XBD=2352 XHG=2306 YBD=528 YHG=493>of " XBD=2548 XHG=2374 YBD=538 YHG=496>strepto-" XBD=1483 XHG=1350 YBD=575 YHG=541>coccal " XBD=1704 XHG=1497 YBD=586 YHG=542>impetigo. " XBD=1800 XHG=1759 YBD=576 YHG=543>It " XBD=1849 XHG=1814 YBD=575 YHG=542>is " XBD=2113 XHG=1866 YBD=577 YHG=546>commonest " XBD=2172 XHG=2128 YBD=577 YHG=543>in " XBD=2325 XHG=2187 YBD=577 YHG=542>adults " XBD=2423 XHG=2340 YBD=576 YHG=542>and " XBD=2553 XHG=2440 YBD=576 YHG=541>older" XBD=1541 XHG=1349 YBD=631 YHG=589>children, " XBD=1640 XHG=1559 YBD=624 YHG=590>and " XBD=1802 XHG=1653 YBD=635 YHG=590>prefers " XBD=1886 XHG=1816 YBD=624 YHG=591>the " XBD=1995 XHG=1899 YBD=626 YHG=591>heat " XBD=2056 XHG=2010 YBD=625 YHG=591>of " XBD=2253 XHG=2066 YBD=626 YHG=603>summer. " XBD=2548 XHG=2310 YBD=635 YHG=590>Obviously," XBD=1459 XHG=1348 YBD=672 YHG=650>more " XBD=1576 XHG=1477 YBD=672 YHG=638>data " XBD=1660 XHG=1593 YBD=673 YHG=649>are " XBD=1830 XHG=1677 YBD=673 YHG=639>needed " XBD=1891 XHG=1847 YBD=673 YHG=642>to " XBD=2019 XHG=1909 YBD=674 YHG=640>show " XBD=2125 XHG=2034 YBD=675 YHG=640>how " XBD=2204 XHG=2140 YBD=675 YHG=640>far " XBD=2302 XHG=2219 YBD=675 YHG=640>this " XBD=2549 XHG=2318 YBD=675 YHG=639>reconcilia-" XBD=1437 XHG=1347 YBD=722 YHG=688>tion " XBD=1495 XHG=1450 YBD=721 YHG=686>of " XBD=1734 XHG=1505 YBD=732 YHG=687>conflicting " XBD=2066 XHG=1747 YBD=734 YHG=687>bacteriological " XBD=2252 XHG=2079 YBD=734 YHG=689>findings " XBD=2333 XHG=2264 YBD=723 YHG=689>fits " XBD=2417 XHG=2346 YBD=723 YHG=689>the " XBD=2547 XHG=2429 YBD=723 YHG=688>facts." XBD=1507 XHG=1348 YBD=781 YHG=736>Among " XBD=1814 XHG=1538 YBD=782 YHG=736>predisposing " XBD=2007 XHG=1844 YBD=777 YHG=735>factors, " XBD=2236 XHG=2033 YBD=772 YHG=737>irritation " XBD=2324 XHG=2267 YBD=784 YHG=738>by " XBD=2548 XHG=2348 YBD=783 YHG=749>exposure" XBD=1392 XHG=1347 YBD=819 YHG=789>to " XBD=1480 XHG=1409 YBD=819 YHG=785>the " XBD=1573 XHG=1496 YBD=819 YHG=796>sun " XBD=1671 XHG=1589 YBD=819 YHG=785>and " XBD=1893 XHG=1687 YBD=819 YHG=785>abrasions " XBD=1955 XHG=1910 YBD=820 YHG=785>of " XBD=2037 XHG=1966 YBD=819 YHG=786>the " XBD=2144 XHG=2053 YBD=820 YHG=786>skin " XBD=2220 XHG=2162 YBD=829 YHG=787>(as " XBD=2342 XHG=2236 YBD=821 YHG=786>from " XBD=2545 XHG=2358 YBD=831 YHG=786>shaving)" XBD=1415 XHG=1347 YBD=869 YHG=845>are " XBD=1636 XHG=1435 YBD=879 YHG=834>probably " XBD=1904 XHG=1654 YBD=879 YHG=834>important ; " XBD=2018 XHG=1942 YBD=869 YHG=834>but " XBD=2089 XHG=2031 YBD=869 YHG=845>we " XBD=2192 XHG=2110 YBD=868 YHG=834>still " XBD=2331 XHG=2210 YBD=869 YHG=835>know " XBD=2421 XHG=2350 YBD=869 YHG=838>too " XBD=2550 XHG=2440 YBD=869 YHG=835>little" XBD=1475 XHG=1347 YBD=917 YHG=883>about " XBD=1609 XHG=1514 YBD=924 YHG=883>this, " XBD=1701 XHG=1657 YBD=916 YHG=894>or " XBD=1867 XHG=1740 YBD=917 YHG=883>about " XBD=1981 XHG=1911 YBD=916 YHG=883>the " XBD=2349 XHG=2021 YBD=928 YHG=884>contagiousness " XBD=2438 XHG=2391 YBD=917 YHG=883>of " XBD=2551 XHG=2477 YBD=918 YHG=884>the" XBD=1554 XHG=1345 YBD=966 YHG=931>infection.

" XBD=1463 XHG=1399 YBD=1016 YHG=980>On " XBD=1563 XHG=1490 YBD=1015 YHG=981>the " XBD=1813 XHG=1591 YBD=1015 YHG=983>treatment " XBD=1939 XHG=1842 YBD=1021 YHG=975>side, " XBD=2077 XHG=1968 YBD=1015 YHG=984>most " XBD=2277 XHG=2105 YBD=1015 YHG=980>workers " XBD=2423 XHG=2306 YBD=1026 YHG=992>agree " XBD=2546 XHG=2451 YBD=1015 YHG=980>that" XBD=1537 XHG=1343 YBD=1076 YHG=1030>impetigo " XBD=1587 XHG=1553 YBD=1064 YHG=1030>is " XBD=1627 XHG=1603 YBD=1064 YHG=1042>a " XBD=1907 XHG=1645 YBD=1075 YHG=1029>self-limiting " XBD=2075 XHG=1923 YBD=1065 YHG=1030>disease " XBD=2173 XHG=2091 YBD=1065 YHG=1030>and " XBD=2282 XHG=2188 YBD=1064 YHG=1030>that " XBD=2369 XHG=2298 YBD=1064 YHG=1030>the " XBD=2546 XHG=2384 YBD=1071 YHG=1029>lesions," XBD=1378 XHG=1343 YBD=1112 YHG=1079>if " XBD=1615 XHG=1404 YBD=1124 YHG=1079>protected " XBD=1725 XHG=1643 YBD=1113 YHG=1078>and " XBD=1899 XHG=1753 YBD=1120 YHG=1079>rested, " XBD=2009 XHG=1929 YBD=1113 YHG=1078>will " XBD=2128 XHG=2036 YBD=1113 YHG=1078>heal " XBD=2475 XHG=2157 YBD=1123 YHG=1078>spontaneously " XBD=2546 XHG=2502 YBD=1112 YHG=1079>in" XBD=1444 XHG=1344 YBD=1162 YHG=1129>7-10 " XBD=1578 XHG=1464 YBD=1172 YHG=1128>days. |>" XBD=1838 XHG=1633 YBD=1163 YHG=1127>SHEEHAN " XBD=1898 XHG=1857 YBD=1163 YHG=1132>et " XBD=1987 XHG=1921 YBD=1170 YHG=1128>al., " XBD=2122 XHG=2007 YBD=1172 YHG=1128>using " XBD=2328 XHG=2141 YBD=1162 YHG=1127>different " XBD=2545 XHG=2349 YBD=1162 YHG=1127>remedies" XBD=1405 XHG=1342 YBD=1211 YHG=1176>for " XBD=1581 XHG=1429 YBD=1211 YHG=1175>similar " XBD=1742 XHG=1598 YBD=1211 YHG=1176>lesions " XBD=1802 XHG=1760 YBD=1211 YHG=1178>in " XBD=1889 XHG=1819 YBD=1212 YHG=1176>the " XBD=2016 XHG=1907 YBD=1212 YHG=1188>same " XBD=2204 XHG=2033 YBD=1223 YHG=1178>patient, " XBD=2389 XHG=2219 YBD=1210 YHG=1176>decided " XBD=2501 XHG=2406 YBD=1210 YHG=1176>that " XBD=2544 XHG=2518 YBD=1210 YHG=1188>a" XBD=1576 XHG=1344 YBD=1270 YHG=1225>compound " XBD=1910 XHG=1591 YBD=1270 YHG=1225>sulphathiazole " XBD=2042 XHG=1926 YBD=1270 YHG=1227>paste " XBD=2135 XHG=2053 YBD=1259 YHG=1236>was " XBD=2222 XHG=2151 YBD=1258 YHG=1225>the " XBD=2329 XHG=2238 YBD=1260 YHG=1225>best " XBD=2485 XHG=2345 YBD=1259 YHG=1235>means " XBD=2549 XHG=2502 YBD=1258 YHG=1225>of" XBD=1608 XHG=1343 YBD=1319 YHG=1274>accelerating " XBD=1817 XHG=1645 YBD=1319 YHG=1273>healing, " XBD=1939 XHG=1858 YBD=1308 YHG=1274>and " XBD=2069 XHG=1975 YBD=1307 YHG=1274>that " XBD=2445 XHG=2106 YBD=1318 YHG=1272>sulphanilamide " XBD=2544 XHG=2485 YBD=1315 YHG=1273>(in" XBD=1545 XHG=1344 YBD=1357 YHG=1324>ointment " XBD=1605 XHG=1562 YBD=1357 YHG=1334>or " XBD=1784 XHG=1622 YBD=1366 YHG=1324>cream), " XBD=2121 XHG=1802 YBD=1366 YHG=1321>gentian-violet, " XBD=2221 XHG=2139 YBD=1356 YHG=1322>and " XBD=2333 XHG=2239 YBD=1366 YHG=1333>ung. " XBD=2540 XHG=2348 YBD=1366 YHG=1321>hydrarg." XBD=1519 XHG=1343 YBD=1407 YHG=1383>ammon. " XBD=1635 XHG=1534 YBD=1406 YHG=1383>were " XBD=1769 XHG=1648 YBD=1405 YHG=1371>much " XBD=1857 XHG=1781 YBD=1404 YHG=1371>less " XBD=2069 XHG=1875 YBD=1405 YHG=1371>effective. " XBD=2207 XHG=2123 YBD=1404 YHG=1370>The " XBD=2370 XHG=2224 YBD=1405 YHG=1369>results " XBD=2541 XHG=2383 YBD=1405 YHG=1370>seemed" XBD=1385 XHG=1341 YBD=1455 YHG=1424>to " XBD=1451 XHG=1401 YBD=1455 YHG=1421>be " XBD=1533 XHG=1464 YBD=1455 YHG=1420>the " XBD=1656 XHG=1549 YBD=1454 YHG=1432>same " XBD=1872 XHG=1672 YBD=1454 YHG=1420>whatever " XBD=1983 XHG=1885 YBD=1454 YHG=1419>kind |>" XBD=2044 XHG=1999 YBD=1454 YHG=1414>of " XBD=2253 XHG=2055 YBD=1465 YHG=1419>organism " XBD=2539 XHG=2267 YBD=1465 YHG=1423>was present." XBD=1472 XHG=1345 YBD=1505 YHG=1470>Other " XBD=1676 XHG=1502 YBD=1505 YHG=1471>workers " XBD=1810 XHG=1705 YBD=1504 YHG=1470>have " XBD=2016 XHG=1840 YBD=1504 YHG=1470>testified " XBD=2091 XHG=2047 YBD=1504 YHG=1473>to " XBD=2193 XHG=2122 YBD=1504 YHG=1469>the " XBD=2470 XHG=2224 YBD=1514 YHG=1470>superiority " XBD=2545 XHG=2499 YBD=1504 YHG=1468>of" XBD=1676 XHG=1343 YBD=1564 YHG=1518>sulphathiazole, " XBD=1742 XHG=1689 YBD=1553 YHG=1530>no " XBD=1904 XHG=1754 YBD=1553 YHG=1521>matter " XBD=2026 XHG=1917 YBD=1553 YHG=1519>what " XBD=2109 XHG=2038 YBD=1552 YHG=1519>the " XBD=2336 XHG=2122 YBD=1564 YHG=1519>excipient. " XBD=2541 XHG=2386 YBD=1553 YHG=1518>Indeed" XBD=1541 XHG=1343 YBD=1609 YHG=1568>HARRIES using " XBD=1719 XHG=1695 YBD=1602 YHG=1579>a " XBD=1837 XHG=1737 YBD=1613 YHG=1567>drop " XBD=1902 XHG=1858 YBD=1602 YHG=1579>or " XBD=2000 XHG=1918 YBD=1602 YHG=1570>two " XBD=2064 XHG=2019 YBD=1602 YHG=1567>of " XBD=2103 XHG=2079 YBD=1601 YHG=1579>a " XBD=2219 XHG=2121 YBD=1613 YHG=1567>20% " XBD=2480 XHG=2241 YBD=1613 YHG=1567>suspension " XBD=2545 XHG=2498 YBD=1601 YHG=1566>of" XBD=1413 XHG=1341 YBD=1651 YHG=1617>the " XBD=1556 XHG=1427 YBD=1651 YHG=1617>new &dquo; " XBD=1924 XHG=1569 YBD=1662 YHG=1616>microcrystalline " XBD=1959 XHG=1937 YBD=1630 YHG=1616>&dquo; " XBD=2294 XHG=1975 YBD=1662 YHG=1615>sulphathiazole " XBD=2360 XHG=2307 YBD=1651 YHG=1628>on " XBD=2399 XHG=2374 YBD=1651 YHG=1628>a " XBD=2541 XHG=2413 YBD=1661 YHG=1627>gauze" XBD=1535 XHG=1343 YBD=1711 YHG=1666>dressing, " XBD=1695 XHG=1547 YBD=1700 YHG=1665>claims " XBD=1804 XHG=1714 YBD=1700 YHG=1677>cure " XBD=1869 XHG=1824 YBD=1700 YHG=1664>of " XBD=1953 XHG=1883 YBD=1699 YHG=1666>the " XBD=2096 XHG=1970 YBD=1700 YHG=1665>lesion " XBD=2156 XHG=2113 YBD=1700 YHG=1666>in " XBD=2224 XHG=2174 YBD=1699 YHG=1666>24 " XBD=2376 XHG=2241 YBD=1700 YHG=1666>hours. " XBD=2540 XHG=2432 YBD=1700 YHG=1664>Such" XBD=1590 XHG=1342 YBD=1749 YHG=1715>accelerated " XBD=1781 XHG=1621 YBD=1760 YHG=1714>healing " XBD=1946 XHG=1812 YBD=1749 YHG=1714>would " XBD=2029 XHG=1978 YBD=1749 YHG=1715>be " XBD=2085 XHG=2060 YBD=1749 YHG=1727>a " XBD=2231 XHG=2116 YBD=1760 YHG=1718>great " XBD=2357 XHG=2262 YBD=1760 YHG=1713>help " XBD=2435 XHG=2386 YBD=1749 YHG=1717>to " XBD=2539 XHG=2467 YBD=1749 YHG=1713>the" XBD=1532 XHG=1342 YBD=1799 YHG=1764>Services. " XBD=1907 XHG=1588 YBD=1808 YHG=1763>Unfortunately " XBD=2000 XHG=1928 YBD=1798 YHG=1764>the " XBD=2257 XHG=2024 YBD=1809 YHG=1763>possibility " XBD=2327 XHG=2281 YBD=1799 YHG=1763>of " XBD=2538 XHG=2346 YBD=1809 YHG=1763>inducing" XBD=1701 XHG=1339 YBD=1858 YHG=1813>hypersensitivity " XBD=1759 XHG=1713 YBD=1847 YHG=1816>to " XBD=1844 XHG=1774 YBD=1846 YHG=1813>the " XBD=1961 XHG=1860 YBD=1858 YHG=1813>drug " XBD=2125 XHG=1977 YBD=1847 YHG=1816>cannot " XBD=2191 XHG=2141 YBD=1848 YHG=1813>be " XBD=2401 XHG=2205 YBD=1858 YHG=1813>ignored.3

SEA-WATER AND BLOOD" XBD=1480 XHG=1388 YBD=1991 YHG=1957>THE " XBD=1650 XHG=1491 YBD=1991 YHG=1956>famous " XBD=1841 XHG=1662 YBD=1991 YHG=1957>doctrine " XBD=1897 XHG=1853 YBD=1992 YHG=1956>of |>|>" XBD=2162 XHG=1903 YBD=1992 YHG=1957>MCCALLUM4 " XBD=2265 XHG=2171 YBD=1991 YHG=1957>that " XBD=2347 XHG=2276 YBD=1991 YHG=1956>the " XBD=2482 XHG=2359 YBD=1991 YHG=1955>blood " XBD=2540 XHG=2493 YBD=1990 YHG=1956>of" XBD=1729 XHG=1335 YBD=2050 YHG=2005>higher vertebrates " XBD=1769 XHG=1735 YBD=2040 YHG=2006>is " XBD=1844 XHG=1775 YBD=2040 YHG=2006>the " XBD=2130 XHG=1850 YBD=2051 YHG=2005>evolutionary " XBD=2383 XHG=2136 YBD=2040 YHG=2005>descendant " XBD=2442 XHG=2395 YBD=2039 YHG=2004>of " XBD=2531 XHG=2449 YBD=2039 YHG=2016>sea-" XBD=1459 XHG=1335 YBD=2089 YHG=2057>water " XBD=1519 XHG=1473 YBD=2096 YHG=2055>is, " XBD=1678 XHG=1535 YBD=2089 YHG=2055>within " XBD=1844 XHG=1688 YBD=2089 YHG=2066>narrow " XBD=1994 XHG=1857 YBD=2096 YHG=2054>limits, " XBD=2032 XHG=2008 YBD=2089 YHG=2066>a " XBD=2202 XHG=2045 YBD=2089 YHG=2055>truism. " XBD=2344 XHG=2255 YBD=2089 YHG=2053>Life " XBD=2533 XHG=2355 YBD=2099 YHG=2054>depends" XBD=1387 XHG=1335 YBD=2138 YHG=2115>on " XBD=1494 XHG=1424 YBD=2137 YHG=2103>the " XBD=1732 XHG=1531 YBD=2138 YHG=2104>existence " XBD=1805 XHG=1760 YBD=2138 YHG=2103>of " XBD=1866 XHG=1840 YBD=2137 YHG=2115>a " XBD=2147 XHG=1896 YBD=2139 YHG=2106>menstruum " XBD=2226 XHG=2183 YBD=2138 YHG=2115>or " XBD=2532 XHG=2256 YBD=2148 YHG=2103>ground-fluid" XBD=1406 XHG=1333 YBD=2186 YHG=2155>not " XBD=1526 XHG=1426 YBD=2197 YHG=2163>very " XBD=1730 XHG=1544 YBD=2187 YHG=2152>different " XBD=1853 XHG=1748 YBD=2187 YHG=2152>from " XBD=2079 XHG=1872 YBD=2187 YHG=2156>sea-water " XBD=2225 XHG=2099 YBD=2186 YHG=2152>either " XBD=2287 XHG=2243 YBD=2186 YHG=2153>in " XBD=2410 XHG=2304 YBD=2187 YHG=2153>ionic " XBD=2531 XHG=2426 YBD=2187 YHG=2163>com-" XBD=1509 XHG=1332 YBD=2246 YHG=2201>position " XBD=1650 XHG=1529 YBD=2244 YHG=2201>(Na+, " XBD=1753 XHG=1668 YBD=2243 YHG=2201>Cl-, " XBD=1853 XHG=1771 YBD=2243 YHG=2201>K+, " XBD=1995 XHG=1871 YBD=2243 YHG=2201>Cay, " XBD=2152 XHG=2012 YBD=2246 YHG=2201>Mg++) " XBD=2218 XHG=2174 YBD=2235 YHG=2213>or " XBD=2279 XHG=2235 YBD=2235 YHG=2201>in " XBD=2407 XHG=2296 YBD=2246 YHG=2212>gross " XBD=2532 XHG=2425 YBD=2236 YHG=2201>ionic" XBD=1588 XHG=1331 YBD=2295 YHG=2250>proportions " XBD=1719 XHG=1608 YBD=2295 YHG=2250>(high |>" XBD=1843 XHG=1736 YBD=2291 YHG=2250>Na+, " XBD=1963 XHG=1863 YBD=2292 YHG=2249>Cl- ; " XBD=2111 XHG=1992 YBD=2284 YHG=2250>lower " XBD=2225 XHG=2128 YBD=2292 YHG=2250>K+ ; " XBD=2384 XHG=2257 YBD=2291 YHG=2249>Ca + +, " XBD=2526 XHG=2404 YBD=2296 YHG=2250>Mg+ +" XBD=1450 XHG=1330 YBD=2332 YHG=2297>lower " XBD=1589 XHG=1476 YBD=2342 YHG=2298>still). " XBD=1897 XHG=1643 YBD=2344 YHG=2298>Protoplasm " XBD=2108 XHG=1923 YBD=2340 YHG=2299>without, " XBD=2198 XHG=2134 YBD=2333 YHG=2298>for " XBD=2422 XHG=2223 YBD=2344 YHG=2298>example, " XBD=2529 XHG=2452 YBD=2333 YHG=2299>cal-" XBD=1450 XHG=1332 YBD=2388 YHG=2347>cium, " XBD=1495 XHG=1472 YBD=2360 YHG=2347>&dquo; " XBD=1547 XHG=1511 YBD=2381 YHG=2347>is " XBD=1829 XHG=1562 YBD=2382 YHG=2346>unthinkable " XBD=1926 XHG=1847 YBD=2388 YHG=2348>&dquo; 5 ; " XBD=2074 XHG=1962 YBD=2382 YHG=2347>&dquo; if a " XBD=2243 XHG=2090 YBD=2382 YHG=2348>marine " XBD=2530 XHG=2261 YBD=2393 YHG=2348>composition" XBD=1375 XHG=1330 YBD=2430 YHG=2395>of " XBD=1458 XHG=1386 YBD=2429 YHG=2395>the " XBD=1650 XHG=1473 YBD=2430 YHG=2395>internal " XBD=1843 XHG=1663 YBD=2431 YHG=2396>medium " XBD=1901 XHG=1858 YBD=2430 YHG=2397>in " XBD=1997 XHG=1915 YBD=2431 YHG=2396>this " XBD=2223 XHG=2012 YBD=2431 YHG=2397>restricted " XBD=2353 XHG=2240 YBD=2430 YHG=2408>sense " XBD=2440 XHG=2369 YBD=2431 YHG=2396>did " XBD=2530 XHG=2455 YBD=2431 YHG=2400>not" XBD=1447 XHG=1329 YBD=2485 YHG=2445>exist, " XBD=1569 XHG=1468 YBD=2479 YHG=2444>then " XBD=1621 XHG=1588 YBD=2479 YHG=2445>it " XBD=1777 XHG=1642 YBD=2480 YHG=2444>would " XBD=1902 XHG=1796 YBD=2480 YHG=2456>seem " XBD=2132 XHG=1922 YBD=2490 YHG=2456>necessary " XBD=2213 XHG=2151 YBD=2480 YHG=2445>for " XBD=2304 XHG=2232 YBD=2479 YHG=2445>the " XBD=2527 XHG=2324 YBD=2490 YHG=2445>organism" XBD=1372 XHG=1327 YBD=2528 YHG=2496>to " XBD=1538 XHG=1395 YBD=2528 YHG=2493>invent " XBD=1634 XHG=1561 YBD=2528 YHG=2493>it.&dquo; " XBD=1664 XHG=1650 YBD=2515 YHG=2496>6 " XBD=1758 XHG=1706 YBD=2528 YHG=2494>It " XBD=1814 XHG=1780 YBD=2528 YHG=2494>is " XBD=2033 XHG=1835 YBD=2528 YHG=2493>therefore " XBD=2253 XHG=2055 YBD=2539 YHG=2493>profitless " XBD=2321 XHG=2275 YBD=2528 YHG=2496>to " XBD=2440 XHG=2343 YBD=2528 YHG=2494>read " XBD=2529 XHG=2475 YBD=2528 YHG=2506>an" XBD=1492 XHG=1327 YBD=2576 YHG=2542>esoteric " XBD=1777 XHG=1525 YBD=2587 YHG=2542>significance " XBD=1895 XHG=1807 YBD=2576 YHG=2543>into " XBD=1996 XHG=1927 YBD=2576 YHG=2543>the " XBD=2188 XHG=2029 YBD=2586 YHG=2542>affinity " XBD=2400 XHG=2218 YBD=2576 YHG=2543>between " XBD=2526 XHG=2442 YBD=2577 YHG=2554>sea-" XBD=1451 XHG=1326 YBD=2625 YHG=2593>water " XBD=1560 XHG=1477 YBD=2625 YHG=2591>and " XBD=1731 XHG=1585 YBD=2631 YHG=2589>blood ; " XBD=1978 XHG=1774 YBD=2635 YHG=2590>biologists " XBD=2072 XHG=2005 YBD=2624 YHG=2602>are " XBD=2230 XHG=2098 YBD=2624 YHG=2590>better " XBD=2449 XHG=2256 YBD=2636 YHG=2591>occupied " XBD=2528 XHG=2483 YBD=2625 YHG=2591>in" XBD=1479 XHG=1326 YBD=2683 YHG=2639>finding " XBD=1571 XHG=1498 YBD=2673 YHG=2642>out " XBD=1699 XHG=1589 YBD=2673 YHG=2650>more " XBD=1800 XHG=1716 YBD=2673 YHG=2639>and " XBD=1924 XHG=1814 YBD=2673 YHG=2650>more " XBD=2102 XHG=1941 YBD=2673 YHG=2650>reasons " XBD=2214 XHG=2120 YBD=2683 YHG=2639>why " XBD=2302 XHG=2230 YBD=2673 YHG=2639>the " XBD=2525 XHG=2331 YBD=2684 YHG=2640>composi-" XBD=1415 XHG=1326 YBD=2722 YHG=2688>tion " XBD=1476 XHG=1431 YBD=2721 YHG=2687>of " XBD=1559 XHG=1488 YBD=2721 YHG=2688>the " XBD=1821 XHG=1575 YBD=2732 YHG=2687>body-fluids " XBD=1998 XHG=1838 YBD=2728 YHG=2690>cannot, " XBD=2058 XHG=2015 YBD=2721 YHG=2687>in " XBD=2169 XHG=2072 YBD=2728 YHG=2686>fact, " XBD=2237 XHG=2187 YBD=2722 YHG=2688>be " XBD=2374 XHG=2253 YBD=2722 YHG=2688>much " XBD=2523 XHG=2390 YBD=2722 YHG=2688>differ-" XBD=1397 XHG=1326 YBD=2770 YHG=2739>ent " XBD=1522 XHG=1416 YBD=2769 YHG=2735>from " XBD=1652 XHG=1542 YBD=2770 YHG=2736>what " XBD=1705 XHG=1668 YBD=2769 YHG=2736>it " XBD=1785 XHG=1722 YBD=2769 YHG=2736>is.7 " XBD=1888 XHG=1847 YBD=2769 YHG=2735>It " XBD=1988 XHG=1908 YBD=2769 YHG=2747>was " XBD=2279 XHG=2009 YBD=2770 YHG=2736>HENDERSON " XBD=2308 XHG=2295 YBD=2757 YHG=2739>B " XBD=2418 XHG=2328 YBD=2770 YHG=2736>who " XBD=2525 XHG=2438 YBD=2770 YHG=2736>first

" XBD=1390 XHG=1324 YBD=2818 YHG=2784>led " XBD=1455 XHG=1407 YBD=2817 YHG=2795>us " XBD=1519 XHG=1473 YBD=2818 YHG=2787>to " XBD=1617 XHG=1536 YBD=2817 YHG=2783>this " XBD=1732 XHG=1636 YBD=2817 YHG=2782>bald " XBD=1971 XHG=1749 YBD=2828 YHG=2784>pragmatic " XBD=2165 XHG=1990 YBD=2818 YHG=2784>solution " XBD=2228 XHG=2184 YBD=2818 YHG=2784>of " XBD=2324 XHG=2253 YBD=2818 YHG=2784>the " XBD=2525 XHG=2342 YBD=2829 YHG=2784>problem" XBD=1371 XHG=1325 YBD=2867 YHG=2831>of " XBD=1420 XHG=1397 YBD=2845 YHG=2831>&dquo; " XBD=1577 XHG=1437 YBD=2866 YHG=2832>fitness " XBD=1616 XHG=1594 YBD=2845 YHG=2832>&dquo; " XBD=1728 XHG=1646 YBD=2865 YHG=2831>and " XBD=2006 XHG=1756 YBD=2876 YHG=2831>adaptation, " XBD=2117 XHG=2035 YBD=2867 YHG=2832>and " XBD=2233 XHG=2143 YBD=2867 YHG=2833>who " XBD=2435 XHG=2261 YBD=2873 YHG=2833>showed, " XBD=2523 XHG=2465 YBD=2876 YHG=2832>by" XBD=1536 XHG=1323 YBD=2925 YHG=2881>reasoning " XBD=1707 XHG=1559 YBD=2914 YHG=2879>similar " XBD=1773 XHG=1726 YBD=2914 YHG=2883>to " XBD=1887 XHG=1794 YBD=2921 YHG=2880>this, " XBD=2003 XHG=1910 YBD=2915 YHG=2881>that " XBD=2094 XHG=2024 YBD=2915 YHG=2882>the " XBD=2183 XHG=2117 YBD=2915 YHG=2892>sea " XBD=2238 XHG=2204 YBD=2914 YHG=2881>is " XBD=2345 XHG=2259 YBD=2925 YHG=2881>just " XBD=2412 XHG=2368 YBD=2914 YHG=2892>as " XBD=2523 XHG=2444 YBD=2914 YHG=2880>for-" XBD=1570 XHG=1324 YBD=2974 YHG=2928>tunately &dquo; " XBD=1766 XHG=1588 YBD=2973 YHG=2928>adapted " XBD=1804 XHG=1783 YBD=2941 YHG=2927>&dquo; " XBD=1882 XHG=1838 YBD=2963 YHG=2931>to " XBD=1983 XHG=1913 YBD=2964 YHG=2929>the " XBD=2117 XHG=2015 YBD=2963 YHG=2929>vital " XBD=2347 XHG=2147 YBD=2973 YHG=2929>workings " XBD=2425 XHG=2379 YBD=2962 YHG=2928>of " XBD=2523 XHG=2451 YBD=2962 YHG=2929>the" XBD=1528 XHG=1325 YBD=3022 YHG=2978>organism " XBD=1586 XHG=1542 YBD=3010 YHG=2988>as " XBD=1671 XHG=1600 YBD=3011 YHG=2977>the " XBD=1885 XHG=1685 YBD=3021 YHG=2977>organism " XBD=1933 XHG=1898 YBD=3012 YHG=2978>is " XBD=1991 XHG=1946 YBD=3012 YHG=2981>to " XBD=2077 XHG=2006 YBD=3011 YHG=2978>the " XBD=2172 XHG=2093 YBD=3011 YHG=2989>sea." XBD=1619 XHG=1374 YBD=3060 YHG=3021>MCCALLUM " XBD=1887 XHG=1637 YBD=3060 YHG=3025>maintained " XBD=2008 XHG=1902 YBD=3067 YHG=3026>that, " XBD=2285 XHG=2027 YBD=3070 YHG=3024>primitively, " XBD=2376 XHG=2305 YBD=3058 YHG=3024>the " XBD=2521 XHG=2394 YBD=3068 YHG=3024>body-" XBD=1442 XHG=1322 YBD=3108 YHG=3074>fluids " XBD=1518 XHG=1471 YBD=3106 YHG=3072>of " XBD=1699 XHG=1546 YBD=3107 YHG=3073>marine " XBD=1901 XHG=1732 YBD=3108 YHG=3073>animals " XBD=2036 XHG=1936 YBD=3108 YHG=3085>were " XBD=2112 XHG=2069 YBD=3106 YHG=3074>in " XBD=2395 XHG=2138 YBD=3117 YHG=3072>equilibrium " XBD=2522 XHG=2423 YBD=3107 YHG=3073>with" XBD=1546 XHG=1323 YBD=3161 YHG=3124>sea-water, " XBD=1670 XHG=1589 YBD=3155 YHG=3121>and " XBD=1804 XHG=1711 YBD=3155 YHG=3122>that " XBD=1915 XHG=1845 YBD=3155 YHG=3122>the " XBD=2116 XHG=1957 YBD=3166 YHG=3124>present " XBD=2438 XHG=2171 YBD=3165 YHG=3121>composition " XBD=2526 XHG=2479 YBD=3154 YHG=3119>of" XBD=1584 XHG=1320 YBD=3204 YHG=3168>mammalian " XBD=1730 XHG=1609 YBD=3203 YHG=3169>blood " XBD=1795 XHG=1761 YBD=3203 YHG=3170>is " XBD=1972 XHG=1826 YBD=3212 YHG=3169>closely " XBD=2151 XHG=2001 YBD=3202 YHG=3168>similar " XBD=2225 XHG=2180 YBD=3202 YHG=3171>to " XBD=2350 XHG=2256 YBD=3202 YHG=3168>that " XBD=2424 XHG=2378 YBD=3202 YHG=3168>of " XBD=2526 XHG=2449 YBD=3202 YHG=3169>the

2. Harris, T. N. J. Amer. med. Ass. Feb. 6, 1943, p. 403.3. Ibid, pp. 406, 408 and 411.4. Physiol. Rev. 1926, 6, 316.5. Pantin, C. F. A. Biol. Rev. 1931, 6, 459.6. Conway, E. J. Proc. R. Irish Acad. B, 1943, 48, 161.7. of. Hogben, L. Nature of Living Matter, London, 1930.8. Fitness of the Environment, New York, 1913.

560 T

" XBD=321 XHG=113 YBD=237 YHG=202>Paleozoic " XBD=414 XHG=346 YBD=236 YHG=213>sea " XBD=554 XHG=437 YBD=237 YHG=201>when " XBD=649 XHG=577 YBD=239 YHG=202>the " XBD=920 XHG=672 YBD=236 YHG=201>vertebrates " XBD=1017 XHG=944 YBD=236 YHG=201>left " XBD=1075 XHG=1041 YBD=236 YHG=202>it " XBD=1182 XHG=1100 YBD=236 YHG=202>and " XBD=1311 XHG=1206 YBD=237 YHG=201>their" XBD=238 XHG=116 YBD=286 YHG=250>blood " XBD=442 XHG=264 YBD=293 YHG=251>became, " XBD=514 XHG=470 YBD=286 YHG=251>in " XBD=564 XHG=540 YBD=287 YHG=263>a " XBD=952 XHG=591 YBD=298 YHG=250>physicochemical " XBD=1105 XHG=980 YBD=292 YHG=262>sense, " XBD=1231 XHG=1134 YBD=285 YHG=251>shut " XBD=1317 XHG=1258 YBD=286 YHG=250>off" XBD=220 XHG=115 YBD=334 YHG=299>from " XBD=283 XHG=237 YBD=335 YHG=300>it. " XBD=526 XHG=337 YBD=335 YHG=299>Brilliant " XBD=626 XHG=544 YBD=335 YHG=300>and " XBD=895 XHG=643 YBD=344 YHG=299>stimulating " XBD=957 XHG=913 YBD=334 YHG=311>as " XBD=1007 XHG=973 YBD=334 YHG=300>it " XBD=1071 XHG=1024 YBD=342 YHG=301>is, " XBD=1152 XHG=1089 YBD=334 YHG=299>his " XBD=1314 XHG=1168 YBD=345 YHG=300>theory" XBD=189 XHG=115 YBD=385 YHG=349>has " XBD=288 XHG=213 YBD=383 YHG=352>not " XBD=416 XHG=313 YBD=384 YHG=350>been " XBD=634 XHG=441 YBD=395 YHG=348>accepted " XBD=715 XHG=658 YBD=393 YHG=348>by " XBD=866 XHG=739 YBD=382 YHG=348>either biologists " XBD=1199 XHG=1114 YBD=383 YHG=351>2 or " XBD=1312 XHG=1224 YBD=394 YHG=359>geo-" XBD=336 XHG=118 YBD=433 YHG=398>chemists.a " XBD=441 XHG=389 YBD=432 YHG=398>In " XBD=528 XHG=457 YBD=433 YHG=399>the " XBD=633 XHG=545 YBD=431 YHG=397>first " XBD=777 XHG=650 YBD=442 YHG=396>place, " XBD=899 XHG=797 YBD=431 YHG=408>even " XBD=988 XHG=916 YBD=432 YHG=397>the " XBD=1254 XHG=1006 YBD=442 YHG=396>body-fluids " XBD=1318 XHG=1273 YBD=432 YHG=396>of" XBD=186 XHG=116 YBD=482 YHG=446>the " XBD=416 XHG=222 YBD=492 YHG=447>majority " XBD=497 XHG=452 YBD=481 YHG=447>of " XBD=680 XHG=528 YBD=480 YHG=446>marine " XBD=1008 XHG=715 YBD=481 YHG=445>invertebrates " XBD=1112 XHG=1045 YBD=481 YHG=458>are " XBD=1238 XHG=1163 YBD=481 YHG=449>not " XBD=1316 XHG=1272 YBD=480 YHG=446>in" XBD=278 XHG=117 YBD=541 YHG=496>passive " XBD=546 XHG=290 YBD=541 YHG=495>equilibrium " XBD=656 XHG=557 YBD=528 YHG=494>with " XBD=998 XHG=670 YBD=530 YHG=495>sea-water-the " XBD=1316 XHG=1012 YBD=530 YHG=495>concentration" XBD=252 XHG=122 YBD=580 YHG=544>ofH+ " XBD=361 XHG=279 YBD=579 YHG=545>and " XBD=449 XHG=382 YBD=578 YHG=543>K+ " XBD=510 XHG=475 YBD=577 YHG=543>is " XBD=667 XHG=527 YBD=587 YHG=542>higher " XBD=791 XHG=688 YBD=578 YHG=544>than " XBD=855 XHG=812 YBD=578 YHG=544>in " XBD=943 XHG=872 YBD=578 YHG=544>the " XBD=1041 XHG=962 YBD=584 YHG=555>sea, " XBD=1143 XHG=1062 YBD=578 YHG=544>and " XBD=1254 XHG=1160 YBD=578 YHG=544>that " XBD=1319 XHG=1273 YBD=578 YHG=543>of" XBD=240 XHG=119 YBD=639 YHG=593>Mg++ " XBD=497 XHG=263 YBD=637 YHG=591>and S04-- " XBD=654 XHG=523 YBD=626 YHG=591>lower. " XBD=799 XHG=710 YBD=627 YHG=591>Still " XBD=897 XHG=820 YBD=627 YHG=592>less " XBD=948 XHG=914 YBD=627 YHG=593>is " XBD=999 XHG=965 YBD=627 YHG=593>it " XBD=1106 XHG=1016 YBD=627 YHG=595>true " XBD=1170 XHG=1125 YBD=626 YHG=591>of " XBD=1312 XHG=1184 YBD=627 YHG=595>verte-" XBD=377 XHG=120 YBD=677 YHG=641>brates-the " XBD=641 XHG=394 YBD=675 YHG=640>fresh-water " XBD=798 XHG=655 YBD=675 YHG=640>teleost " XBD=889 XHG=815 YBD=676 YHG=642>has " XBD=947 XHG=903 YBD=676 YHG=645>to " XBD=1071 XHG=961 YBD=676 YHG=642>work " XBD=1129 XHG=1084 YBD=676 YHG=644>to " XBD=1314 XHG=1144 YBD=686 YHG=644>prevent" XBD=232 XHG=120 YBD=725 YHG=690>itself " XBD=429 XHG=254 YBD=735 YHG=689>swelling " XBD=511 XHG=454 YBD=735 YHG=701>up " XBD=628 XHG=546 YBD=724 YHG=690>and " XBD=848 XHG=653 YBD=735 YHG=689>bursting, " XBD=946 XHG=876 YBD=724 YHG=690>the " XBD=1133 XHG=980 YBD=724 YHG=690>marine " XBD=1314 XHG=1168 YBD=726 YHG=690>teleost" XBD=166 XHG=120 YBD=773 YHG=742>to " XBD=354 XHG=184 YBD=784 YHG=741>prevent " XBD=484 XHG=372 YBD=773 YHG=737>itself " XBD=618 XHG=500 YBD=784 YHG=737>being " XBD=875 XHG=637 YBD=774 YHG=738>desiccated. " XBD=1045 XHG=928 YBD=779 YHG=739>True, " XBD=1135 XHG=1065 YBD=772 YHG=738>the " XBD=1312 XHG=1156 YBD=773 YHG=738>cartila-" XBD=264 XHG=122 YBD=833 YHG=788>ginous " XBD=362 XHG=286 YBD=822 YHG=787>fish " XBD=491 XHG=385 YBD=822 YHG=787>have " XBD=654 XHG=513 YBD=823 YHG=788>bloods " XBD=845 XHG=676 YBD=823 YHG=788>isotonic " XBD=967 XHG=868 YBD=822 YHG=787>with " XBD=1212 XHG=991 YBD=829 YHG=790>sea-water, " XBD=1314 XHG=1237 YBD=822 YHG=788>but" XBD=192 XHG=122 YBD=872 YHG=836>the " XBD=379 XHG=224 YBD=883 YHG=840>greater " XBD=505 XHG=411 YBD=884 YHG=840>part " XBD=581 XHG=536 YBD=872 YHG=837>of " XBD=715 XHG=609 YBD=872 YHG=838>their " XBD=915 XHG=749 YBD=872 YHG=837>osmotic " XBD=1047 XHG=948 YBD=871 YHG=836>debt " XBD=1111 XHG=1078 YBD=870 YHG=837>is " XBD=1240 XHG=1143 YBD=882 YHG=836>paid " XBD=1315 XHG=1271 YBD=871 YHG=837>in" XBD=284 XHG=124 YBD=932 YHG=887>organic " XBD=662 XHG=311 YBD=933 YHG=898>currency-urea. " XBD=841 XHG=716 YBD=922 YHG=887>There " XBD=900 XHG=866 YBD=920 YHG=886>is " XBD=978 XHG=924 YBD=921 YHG=897>no " XBD=1194 XHG=1005 YBD=920 YHG=886>evidence " XBD=1314 XHG=1220 YBD=920 YHG=886>that" XBD=194 XHG=124 YBD=970 YHG=936>the " XBD=341 XHG=218 YBD=971 YHG=935>blood " XBD=410 XHG=365 YBD=971 YHG=936>of " XBD=679 XHG=430 YBD=971 YHG=937>vertebrates " XBD=784 XHG=702 YBD=971 YHG=948>was " XBD=900 XHG=808 YBD=970 YHG=947>ever " XBD=966 XHG=923 YBD=969 YHG=937>in " XBD=1149 XHG=989 YBD=980 YHG=935>passive " XBD=1311 XHG=1173 YBD=980 YHG=935>equili-" XBD=258 XHG=126 YBD=1020 YHG=985>brium " XBD=386 XHG=286 YBD=1020 YHG=985>with " XBD=634 XHG=415 YBD=1021 YHG=989>sea-water. " XBD=816 XHG=688 YBD=1020 YHG=986>Given " XBD=869 XHG=845 YBD=1020 YHG=997>a " XBD=1075 XHG=897 YBD=1029 YHG=984>working " XBD=1313 XHG=1103 YBD=1029 YHG=987>excretory" XBD=371 XHG=124 YBD=1069 YHG=1035>mechanism " XBD=618 XHG=387 YBD=1080 YHG=1034>constantly " XBD=833 XHG=632 YBD=1080 YHG=1034>depleting " XBD=917 XHG=848 YBD=1068 YHG=1034>the " XBD=1105 XHG=932 YBD=1068 YHG=1033>internal " XBD=1310 XHG=1120 YBD=1075 YHG=1034>medium,

PANTRN " XBD=505 XHG=306 YBD=1118 YHG=1083>2 believes " XBD=612 XHG=519 YBD=1119 YHG=1084>that " XBD=695 XHG=625 YBD=1118 YHG=1084>the " XBD=894 XHG=709 YBD=1119 YHG=1084>essential " XBD=1118 XHG=908 YBD=1118 YHG=1083>difference " XBD=1314 XHG=1131 YBD=1118 YHG=1084>between" XBD=194 XHG=124 YBD=1166 YHG=1133>the " XBD=330 XHG=225 YBD=1167 YHG=1133>ionic " XBD=615 XHG=361 YBD=1178 YHG=1133>proportions " XBD=692 XHG=648 YBD=1167 YHG=1133>of " XBD=841 XHG=720 YBD=1168 YHG=1133>blood " XBD=953 XHG=873 YBD=1167 YHG=1133>and " XBD=1193 XHG=986 YBD=1168 YHG=1136>sea-water " XBD=1312 XHG=1228 YBD=1176 YHG=1133>(the" XBD=334 XHG=125 YBD=1226 YHG=1180>relatively " XBD=441 XHG=344 YBD=1228 YHG=1181>high " XBD=517 XHG=451 YBD=1216 YHG=1182>K+ " XBD=617 XHG=536 YBD=1216 YHG=1182>and " XBD=707 XHG=630 YBD=1217 YHG=1182>low " XBD=862 XHG=722 YBD=1228 YHG=1181>Mg+ +) " XBD=954 XHG=879 YBD=1216 YHG=1194>can " XBD=1017 XHG=967 YBD=1217 YHG=1182>be " XBD=1243 XHG=1030 YBD=1228 YHG=1182>explained " XBD=1314 XHG=1258 YBD=1227 YHG=1182>by" XBD=196 XHG=125 YBD=1265 YHG=1231>the " XBD=452 XHG=220 YBD=1266 YHG=1230>differences " XBD=518 XHG=474 YBD=1266 YHG=1231>in " XBD=610 XHG=540 YBD=1266 YHG=1232>the " XBD=848 XHG=633 YBD=1266 YHG=1231>mobilities " XBD=916 XHG=872 YBD=1266 YHG=1231>of " XBD=1005 XHG=935 YBD=1266 YHG=1232>the " XBD=1116 XHG=1028 YBD=1267 YHG=1232>ions " XBD=1222 XHG=1140 YBD=1266 YHG=1231>and " XBD=1315 XHG=1244 YBD=1267 YHG=1232>the" XBD=213 XHG=125 YBD=1315 YHG=1283>rate " XBD=290 XHG=245 YBD=1315 YHG=1283>at " XBD=456 XHG=325 YBD=1315 YHG=1280>which " XBD=593 XHG=493 YBD=1327 YHG=1281>they " XBD=826 XHG=629 YBD=1316 YHG=1280>therefore " XBD=956 XHG=864 YBD=1327 YHG=1293>pass " XBD=1126 XHG=995 YBD=1317 YHG=1293>across " XBD=1352 XHG=1153 YBD=1322 YHG=1280>natural" XBD=379 XHG=126 YBD=1365 YHG=1330>membranes " XBD=511 XHG=405 YBD=1365 YHG=1330>from " XBD=611 XHG=540 YBD=1366 YHG=1331>the " XBD=808 XHG=639 YBD=1366 YHG=1330>outside. " XBD=988 XHG=862 YBD=1366 YHG=1331>These " XBD=1246 XHG=1016 YBD=1367 YHG=1332>differences " XBD=1317 XHG=1273 YBD=1366 YHG=1332>in

" XBD=315 XHG=127 YBD=1425 YHG=1379>mobility " XBD=416 XHG=335 YBD=1414 YHG=1379>will " XBD=489 XHG=438 YBD=1415 YHG=1380>be |>" XBD=775 XHG=510 YBD=1433 YHG=1381>exaggerated " XBD=852 XHG=794 YBD=1425 YHG=1381>by " XBD=942 XHG=871 YBD=1415 YHG=1381>the " XBD=1149 XHG=963 YBD=1426 YHG=1382>negative " XBD=1316 XHG=1173 YBD=1426 YHG=1381>charge" XBD=280 XHG=129 YBD=1464 YHG=1429>carried " XBD=356 XHG=299 YBD=1474 YHG=1429>by " XBD=482 XHG=374 YBD=1464 YHG=1432>most " XBD=663 XHG=502 YBD=1464 YHG=1430>natural " XBD=959 XHG=682 YBD=1464 YHG=1430>membranes.9" XBD=263 XHG=178 YBD=1514 YHG=1478>The " XBD=558 XHG=292 YBD=1525 YHG=1479>geochemical " XBD=774 XHG=586 YBD=1514 YHG=1479>evidence " XBD=835 XHG=800 YBD=1513 YHG=1479>is " XBD=915 XHG=862 YBD=1514 YHG=1491>no " XBD=1051 XHG=942 YBD=1514 YHG=1491>more " XBD=1316 XHG=1078 YBD=1524 YHG=1479>reassuring." XBD=212 XHG=128 YBD=1564 YHG=1528>The " XBD=415 XHG=228 YBD=1564 YHG=1528>essential " XBD=584 XHG=429 YBD=1564 YHG=1528>feature " XBD=646 XHG=601 YBD=1563 YHG=1528>of " XBD=941 XHG=662 YBD=1563 YHG=1528>McCALMJM’s " XBD=1103 XHG=957 YBD=1575 YHG=1529>theory " XBD=1150 XHG=1117 YBD=1564 YHG=1529>is " XBD=1260 XHG=1166 YBD=1564 YHG=1529>that " XBD=1320 XHG=1276 YBD=1563 YHG=1529>in" XBD=375 XHG=132 YBD=1614 YHG=1577>Ordovician " XBD=512 XHG=392 YBD=1613 YHG=1578>times " XBD=575 XHG=532 YBD=1613 YHG=1590>or " XBD=853 XHG=593 YBD=1613 YHG=1578>thereabouts " XBD=942 XHG=872 YBD=1613 YHG=1578>the " XBD=1029 XHG=962 YBD=1613 YHG=1590>sea " XBD=1131 XHG=1047 YBD=1613 YHG=1578>had " XBD=1220 XHG=1150 YBD=1613 YHG=1579>the " XBD=1319 XHG=1240 YBD=1613 YHG=1578>salt" XBD=433 XHG=131 YBD=1664 YHG=1627>concentration " XBD=502 XHG=457 YBD=1662 YHG=1627>of " XBD=784 XHG=524 YBD=1674 YHG=1628>present-day " XBD=1083 XHG=806 YBD=1666 YHG=1627>mammalian blood " XBD=1320 XHG=1238 YBD=1663 YHG=1628>and" XBD=224 XHG=130 YBD=1713 YHG=1678>that " XBD=275 XHG=241 YBD=1713 YHG=1677>it " XBD=366 XHG=292 YBD=1713 YHG=1678>has " XBD=487 XHG=384 YBD=1712 YHG=1678>been " XBD=660 XHG=505 YBD=1723 YHG=1678>getting " XBD=858 XHG=686 YBD=1723 YHG=1677>steadily " XBD=992 XHG=872 YBD=1712 YHG=1677>salter " XBD=1123 XHG=1011 YBD=1712 YHG=1678>since’ " XBD=1223 XHG=1138 YBD=1722 YHG=1677>(the " XBD=1321 XHG=1242 YBD=1712 YHG=1676>salt" XBD=251 XHG=131 YBD=1773 YHG=1727>being " XBD=314 XHG=269 YBD=1762 YHG=1727>of " XBD=509 XHG=327 YBD=1762 YHG=1726>volcanic " XBD=667 XHG=528 YBD=1773 YHG=1727>origin, " XBD=731 XHG=687 YBD=1762 YHG=1739>or " XBD=868 XHG=749 YBD=1772 YHG=1727>being " XBD=1039 XHG=888 YBD=1762 YHG=1727>carried " XBD=1144 XHG=1056 YBD=1762 YHG=1728>into " XBD=1233 XHG=1162 YBD=1762 YHG=1727>the " XBD=1320 XHG=1253 YBD=1762 YHG=1738>sea" XBD=188 XHG=131 YBD=1823 YHG=1777>by " XBD=282 XHG=211 YBD=1812 YHG=1777>the " XBD=430 XHG=305 YBD=1812 YHG=1778>rivers " XBD=499 XHG=455 YBD=1811 YHG=1788>as " XBD=548 XHG=524 YBD=1811 YHG=1789>a " XBD=697 XHG=571 YBD=1812 YHG=1776>result " XBD=766 XHG=721 YBD=1811 YHG=1776>of " XBD=885 XHG=788 YBD=1812 YHG=1777>rock " XBD=1092 XHG=909 YBD=1821 YHG=1777>erosion). " XBD=1199 XHG=1147 YBD=1811 YHG=1777>In " XBD=1320 XHG=1221 YBD=1818 YHG=1776>fact," XBD=327 XHG=131 YBD=1868 YHG=1827>however, " XBD=472 XHG=363 YBD=1871 YHG=1826>large " XBD=585 XHG=507 YBD=1860 YHG=1825>salt " XBD=796 XHG=620 YBD=1871 YHG=1826>deposits " XBD=899 XHG=832 YBD=1860 YHG=1837>are " XBD=1080 XHG=931 YBD=1861 YHG=1826>known " XBD=1157 XHG=1114 YBD=1861 YHG=1827>in " XBD=1322 XHG=1191 YBD=1861 YHG=1829>strata" XBD=272 XHG=131 YBD=1922 YHG=1876>dating " XBD=406 XHG=299 YBD=1910 YHG=1876>from " XBD=660 XHG=433 YBD=1916 YHG=1875>Cambrian, " XBD=1005 XHG=690 YBD=1910 YHG=1875>Permian-Trias " XBD=1116 XHG=1033 YBD=1910 YHG=1876>and " XBD=1323 XHG=1142 YBD=1911 YHG=1876>Miocene" XBD=263 XHG=131 YBD=1968 YHG=1926>times, " XBD=368 XHG=287 YBD=1960 YHG=1926>and " XBD=504 XHG=389 YBD=1960 YHG=1925>there " XBD=557 XHG=524 YBD=1959 YHG=1925>is " XBD=748 XHG=579 YBD=1971 YHG=1925>nothing " XBD=815 XHG=770 YBD=1960 YHG=1928>to " XBD=998 XHG=839 YBD=1971 YHG=1928>suggest " XBD=1112 XHG=1019 YBD=1960 YHG=1925>that " XBD=1234 XHG=1133 YBD=1971 YHG=1926>they " XBD=1322 XHG=1255 YBD=1960 YHG=1929>are" XBD=201 XHG=130 YBD=2010 YHG=1975>the " XBD=409 XHG=215 YBD=2022 YHG=1976>products " XBD=472 XHG=428 YBD=2010 YHG=1974>of " XBD=553 XHG=482 YBD=2010 YHG=1975>the " XBD=712 XHG=569 YBD=2020 YHG=1975>drying " XBD=781 XHG=726 YBD=2021 YHG=1986>up " XBD=841 XHG=797 YBD=2009 YHG=1974>of " XBD=1037 XHG=853 YBD=2010 YHG=1975>different " XBD=1169 XHG=1051 YBD=2021 YHG=1979>types " XBD=1230 XHG=1185 YBD=2010 YHG=1975>of " XBD=1321 XHG=1242 YBD=2010 YHG=1987>sea.|>" XBD=349 XHG=132 YBD=2061 YHG=2025>CONWAY has " XBD=557 XHG=453 YBD=2060 YHG=2025>tried " XBD=613 XHG=568 YBD=2060 YHG=2028>to " XBD=818 XHG=626 YBD=2060 YHG=2024>calculate " XBD=906 XHG=836 YBD=2060 YHG=2025>the " XBD=1003 XHG=924 YBD=2061 YHG=2025>salt " XBD=1324 XHG=1022 YBD=2060 YHG=2025>concentration" XBD=181 XHG=135 YBD=2111 YHG=2075>of " XBD=274 XHG=202 YBD=2110 YHG=2076>the " XBD=501 XHG=294 YBD=2110 YHG=2075>Paleozoic " XBD=587 XHG=520 YBD=2110 YHG=2087>sea " XBD=662 XHG=609 YBD=2109 YHG=2086>on " XBD=754 XHG=684 YBD=2109 YHG=2075>the " XBD=951 XHG=776 YBD=2121 YHG=2075>grounds " XBD=1017 XHG=973 YBD=2110 YHG=2074>of " XBD=1123 XHG=1041 YBD=2110 YHG=2079>two " XBD=1324 XHG=1145 YBD=2110 YHG=2078>extreme" XBD=403 XHG=132 YBD=2171 YHG=2125>hypotheses : " XBD=496 XHG=442 YBD=2169 YHG=2125>(a) " XBD=706 XHG=519 YBD=2159 YHG=2127>constant " XBD=1027 XHG=726 YBD=2159 YHG=2124>ocean-volume " XBD=1129 XHG=1047 YBD=2159 YHG=2125>and " XBD=1324 XHG=1149 YBD=2159 YHG=2124>chloride" XBD=326 XHG=135 YBD=2216 YHG=2178>content; " XBD=417 XHG=365 YBD=2218 YHG=2174>(b) " XBD=628 XHG=440 YBD=2209 YHG=2176>constant " XBD=949 XHG=648 YBD=2209 YHG=2173>ocean-volume " XBD=1068 XHG=969 YBD=2208 YHG=2174>with " XBD=1262 XHG=1088 YBD=2209 YHG=2173>chloride " XBD=1329 XHG=1283 YBD=2209 YHG=2173>of" XBD=315 XHG=133 YBD=2259 YHG=2223>volcanic " XBD=488 XHG=349 YBD=2269 YHG=2224>origin. " XBD=628 XHG=542 YBD=2258 YHG=2224>The " XBD=864 XHG=659 YBD=2258 YHG=2223>estimates " XBD=958 XHG=896 YBD=2258 YHG=2223>for " XBD=1061 XHG=990 YBD=2257 YHG=2223>the " XBD=1324 XHG=1093 YBD=2258 YHG=2223>Cambrian-" XBD=380 XHG=137 YBD=2309 YHG=2273>Ordovician " XBD=556 XHG=410 YBD=2319 YHG=2273>epochs " XBD=639 XHG=587 YBD=2308 YHG=2273>do " XBD=742 XHG=669 YBD=2308 YHG=2276>not " XBD=887 XHG=773 YBD=2308 YHG=2273>differ " XBD=1099 XHG=918 YBD=2318 YHG=2272>greatly : " XBD=1217 XHG=1146 YBD=2307 YHG=2273>the " XBD=1326 XHG=1247 YBD=2307 YHG=2272>salt" XBD=440 XHG=137 YBD=2358 YHG=2324>concentration " XBD=512 XHG=478 YBD=2357 YHG=2323>is " XBD=634 XHG=552 YBD=2358 YHG=2322>still " XBD=800 XHG=674 YBD=2358 YHG=2323>about " XBD=952 XHG=839 YBD=2358 YHG=2323>three " XBD=1110 XHG=991 YBD=2357 YHG=2323>times " XBD=1244 XHG=1149 YBD=2357 YHG=2322>that " XBD=1331 XHG=1284 YBD=2357 YHG=2321>of" XBD=397 XHG=134 YBD=2407 YHG=2372>mammalian " XBD=538 XHG=404 YBD=2414 YHG=2372>blood, " XBD=631 XHG=549 YBD=2408 YHG=2373>and " XBD=708 XHG=638 YBD=2407 YHG=2373>the " XBD=1019 XHG=718 YBD=2407 YHG=2372>concentration " XBD=1072 XHG=1028 YBD=2406 YHG=2371>of " XBD=1327 XHG=1078 YBD=2417 YHG=2372>magnesium" XBD=170 XHG=135 YBD=2457 YHG=2422>is " XBD=321 XHG=182 YBD=2468 YHG=2422>higher " XBD=439 XHG=334 YBD=2457 YHG=2422>than " XBD=548 XHG=455 YBD=2456 YHG=2422>that " XBD=611 XHG=565 YBD=2456 YHG=2421>of " XBD=858 XHG=623 YBD=2467 YHG=2423>potassium. " XBD=977 XHG=913 YBD=2456 YHG=2422>He " XBD=1040 XHG=993 YBD=2463 YHG=2422>is, " XBD=1102 XHG=1058 YBD=2455 YHG=2421>in " XBD=1244 XHG=1120 YBD=2463 YHG=2422>short, " XBD=1329 XHG=1262 YBD=2456 YHG=2421>led" XBD=180 XHG=135 YBD=2506 YHG=2475>to " XBD=362 XHG=204 YBD=2506 YHG=2471>dismiss " XBD=665 XHG=386 YBD=2506 YHG=2471>McCAijijOTM’s " XBD=810 XHG=690 YBD=2506 YHG=2472>views " XBD=878 XHG=835 YBD=2505 YHG=2482>as " XBD=926 XHG=905 YBD=2485 YHG=2470>&dquo; " XBD=1168 XHG=946 YBD=2516 YHG=2470>superficial " XBD=1327 XHG=1193 YBD=2505 YHG=2470>evolu-" XBD=341 XHG=136 YBD=2555 YHG=2520>tionism.&dquo; " XBD=614 XHG=397 YBD=2556 YHG=2520>Sea-water " XBD=717 XHG=635 YBD=2555 YHG=2520>and " XBD=805 XHG=734 YBD=2555 YHG=2521>the " XBD=947 XHG=826 YBD=2555 YHG=2520>blood " XBD=1013 XHG=968 YBD=2554 YHG=2520>of " XBD=1241 XHG=1028 YBD=2555 YHG=2520>mammals " XBD=1329 XHG=1261 YBD=2554 YHG=2531>are" XBD=462 XHG=136 YBD=2615 YHG=2568>fundamentally " XBD=632 XHG=483 YBD=2604 YHG=2569>similar " XBD=822 XHG=653 YBD=2604 YHG=2570>because " XBD=969 XHG=843 YBD=2604 YHG=2569>that’s " XBD=1060 XHG=990 YBD=2604 YHG=2570>the " XBD=1172 XHG=1082 YBD=2614 YHG=2581>way " XBD=1330 XHG=1192 YBD=2615 YHG=2569>things" XBD=232 XHG=139 YBD=2659 YHG=2629>are ; " XBD=323 XHG=264 YBD=2652 YHG=2630>we " XBD=451 XHG=340 YBD=2653 YHG=2622>must " XBD=631 XHG=467 YBD=2653 YHG=2619>become " XBD=936 XHG=649 YBD=2665 YHG=2619>sophisticated " XBD=1110 XHG=953 YBD=2663 YHG=2619>enough " XBD=1171 XHG=1127 YBD=2653 YHG=2622>to " XBD=1329 XHG=1188 YBD=2653 YHG=2618>realise" XBD=232 XHG=138 YBD=2701 YHG=2668>that " XBD=340 XHG=259 YBD=2701 YHG=2667>this " XBD=679 XHG=367 YBD=2713 YHG=2668>interpretation " XBD=739 XHG=705 YBD=2703 YHG=2669>is " XBD=839 XHG=766 YBD=2703 YHG=2671>not " XBD=1006 XHG=866 YBD=2713 YHG=2667>nearly " XBD=1077 XHG=1033 YBD=2702 YHG=2679>as " XBD=1197 XHG=1107 YBD=2713 YHG=2667>silly " XBD=1269 XHG=1225 YBD=2701 YHG=2679>as " XBD=1331 XHG=1296 YBD=2702 YHG=2668>it

VITAMIN B1 AND SHOCK" XBD=282 XHG=190 YBD=2889 YHG=2855>THE " XBD=382 XHG=299 YBD=2889 YHG=2866>war " XBD=472 XHG=399 YBD=2890 YHG=2856>has " XBD=552 XHG=487 YBD=2889 YHG=2854>led " XBD=613 XHG=568 YBD=2890 YHG=2858>to " XBD=700 XHG=630 YBD=2890 YHG=2857>the " XBD=841 XHG=718 YBD=2901 YHG=2857>study " XBD=902 XHG=858 YBD=2891 YHG=2856>of " XBD=1106 XHG=914 YBD=2891 YHG=2857>vitamins " XBD=1228 XHG=1123 YBD=2891 YHG=2856>from " XBD=1331 XHG=1245 YBD=2892 YHG=2868>new" XBD=289 XHG=143 YBD=2950 YHG=2903>angles. " XBD=422 XHG=342 YBD=2939 YHG=2903>For " XBD=636 XHG=440 YBD=2949 YHG=2904>example, " XBD=828 XHG=655 YBD=2940 YHG=2905>vitamin " XBD=881 XHG=851 YBD=2940 YHG=2906>C " XBD=977 XHG=904 YBD=2939 YHG=2906>has " XBD=1102 XHG=1000 YBD=2940 YHG=2906>been " XBD=1264 XHG=1126 YBD=2940 YHG=2906>shown " XBD=1332 XHG=1286 YBD=2941 YHG=2910>to" XBD=324 XHG=143 YBD=2988 YHG=2954>decrease " XBD=421 XHG=350 YBD=2988 YHG=2953>the " XBD=656 XHG=445 YBD=2999 YHG=2953>mortality " XBD=726 XHG=682 YBD=2988 YHG=2953>of " XBD=978 XHG=747 YBD=3000 YHG=2954>guineapigs " XBD=1213 XHG=1005 YBD=2999 YHG=2954>subjected " XBD=1282 XHG=1237 YBD=2989 YHG=2957>to " XBD=1332 XHG=1307 YBD=2989 YHG=2967>a" XBD=346 XHG=142 YBD=3045 YHG=3005>trauma,1o " XBD=449 XHG=366 YBD=3037 YHG=3003>and " XBD=510 XHG=465 YBD=3037 YHG=3005>to " XBD=695 XHG=527 YBD=3048 YHG=3002>prolong " XBD=788 XHG=718 YBD=3037 YHG=3003>the " XBD=878 XHG=809 YBD=3038 YHG=3002>life " XBD=946 XHG=902 YBD=3039 YHG=3003>of " XBD=1053 XHG=967 YBD=3038 YHG=3007>cats " XBD=1206 XHG=1075 YBD=3039 YHG=3004>which " XBD=1333 XHG=1228 YBD=3039 YHG=3004>have" XBD=243 XHG=142 YBD=3087 YHG=3053>been " XBD=591 XHG=267 YBD=3098 YHG=3051>bled-possibly " XBD=668 XHG=611 YBD=3097 YHG=3052>by " XBD=904 XHG=685 YBD=3098 YHG=3052>increasing " XBD=997 XHG=927 YBD=3087 YHG=3052>the " XBD=1274 XHG=1022 YBD=3099 YHG=3053>availability " XBD=1338 XHG=1292 YBD=3088 YHG=3053>of" XBD=301 XHG=143 YBD=3147 YHG=3113>oxygen " XBD=353 XHG=308 YBD=3137 YHG=3105>to " XBD=432 XHG=362 YBD=3136 YHG=3102>the " XBD=627 XHG=441 YBD=3136 YHG=3102>tissues " XBD=833 XHG=652 YBD=3136 YHG=3101>Vitamin " XBD=896 XHG=842 YBD=3148 YHG=3102>Bl " XBD=987 XHG=905 YBD=3137 YHG=3101>also " XBD=1069 XHG=997 YBD=3138 YHG=3102>has " XBD=1183 XHG=1082 YBD=3137 YHG=3103>been " XBD=1334 XHG=1196 YBD=3137 YHG=3103>shown" XBD=198 XHG=142 YBD=3196 YHG=3151>by " XBD=387 XHG=220 YBD=3186 YHG=3151>GOVIER " XBD=491 XHG=410 YBD=3186 YHG=3151>and " XBD=710 XHG=519 YBD=3186 YHG=3150>GREER 12 " XBD=784 XHG=739 YBD=3185 YHG=3153>to " XBD=977 XHG=811 YBD=3195 YHG=3151>prolong " XBD=1074 XHG=1004 YBD=3186 YHG=3147>the " XBD=1169 XHG=1100 YBD=3185 YHG=3151>life " XBD=1242 XHG=1198 YBD=3185 YHG=3150>of " XBD=1332 XHG=1267 YBD=3187 YHG=3163>ex-" XBD=411 XHG=144 YBD=3245 YHG=3200>sanguinated " XBD=606 XHG=423 YBD=3241 YHG=3199>animals, " XBD=702 XHG=621 YBD=3234 YHG=3200>and " XBD=759 XHG=714 YBD=3234 YHG=3202>to " XBD=962 XHG=773 YBD=3233 YHG=3199>diminish " XBD=1044 XHG=973 YBD=3234 YHG=3201>the " XBD=1334 XHG=1058 YBD=3234 YHG=3200>disturbances" XBD=185 XHG=142 YBD=3283 YHG=3249>in " XBD=509 XHG=214 YBD=3294 YHG=3249>carbohydrate " XBD=792 XHG=536 YBD=3283 YHG=3248>metabolism " XBD=1020 XHG=820 YBD=3293 YHG=3247>following " XBD=1333 XHG=1048 YBD=3294 YHG=3249>haemorrhage." XBD=198 XHG=148 YBD=3332 YHG=3298>In " XBD=317 XHG=212 YBD=3332 YHG=3298>their " XBD=419 XHG=332 YBD=3333 YHG=3298>first " XBD=702 XHG=435 YBD=3344 YHG=3299>experiments " XBD=816 XHG=717 YBD=3342 YHG=3297>they " XBD=1019 XHG=830 YBD=3331 YHG=3298>removed " XBD=1193 XHG=1032 YBD=3342 YHG=3297>rapidly " XBD=1336 XHG=1209 YBD=3332 YHG=3298>about

9. cf. Baldwin, E. Comparative Biochemistry, Cambridge, 1940.10. Ungar, G. Lancet, 1943, i, 421.11. Stewart, C. P., Learmonth, J. R., Pollock,G.A. Lancet,1941, i, 818.12. Govier, W. M., Greer, C. M. J. Pharmacol. 1941, 72, 317.

" XBD=1403 XHG=1378 YBD=236 YHG=214>a " XBD=1525 XHG=1414 YBD=236 YHG=202>third " XBD=1582 XHG=1538 YBD=237 YHG=201>of " XBD=1661 XHG=1591 YBD=237 YHG=202>the " XBD=1907 XHG=1675 YBD=248 YHG=202>circulating " XBD=2041 XHG=1920 YBD=237 YHG=202>blood " XBD=2157 XHG=2053 YBD=237 YHG=202>from " XBD=2266 XHG=2170 YBD=247 YHG=203>dogs " XBD=2524 XHG=2279 YBD=237 YHG=202>anaesthetised" XBD=1474 XHG=1376 YBD=285 YHG=251>with " XBD=1613 XHG=1490 YBD=286 YHG=251>ether. " XBD=1751 XHG=1667 YBD=286 YHG=251>The " XBD=1948 XHG=1767 YBD=292 YHG=251>animals, " XBD=2093 XHG=1964 YBD=285 YHG=250>which " XBD=2287 XHG=2108 YBD=285 YHG=251>received " XBD=2525 XHG=2300 YBD=285 YHG=251>intravenous" XBD=1459 XHG=1377 YBD=335 YHG=300>and " XBD=1789 XHG=1481 YBD=335 YHG=299>intramuscular " XBD=2023 XHG=1812 YBD=343 YHG=300>injections " XBD=2091 XHG=2047 YBD=334 YHG=300>of " XBD=2281 XHG=2111 YBD=333 YHG=300>vitamin " XBD=2352 XHG=2302 YBD=345 YHG=299>Bl " XBD=2524 XHG=2372 YBD=333 YHG=299>immedi-" XBD=1489 XHG=1378 YBD=394 YHG=348>ately " XBD=1617 XHG=1514 YBD=383 YHG=349>after " XBD=1839 XHG=1643 YBD=394 YHG=348>bleeding, " XBD=2056 XHG=1868 YBD=382 YHG=348>survived " XBD=2135 XHG=2083 YBD=382 YHG=359>on " XBD=2229 XHG=2159 YBD=382 YHG=348>the " XBD=2411 XHG=2254 YBD=392 YHG=353>average " XBD=2485 XHG=2433 YBD=382 YHG=347>for " XBD=2525 XHG=2507 YBD=382 YHG=349>8" XBD=1512 XHG=1377 YBD=438 YHG=397>hours, " XBD=1710 XHG=1535 YBD=433 YHG=398>whereas " XBD=1845 XHG=1729 YBD=431 YHG=396>those " XBD=1958 XHG=1865 YBD=431 YHG=397>that " XBD=2079 XHG=1978 YBD=431 YHG=408>were " XBD=2172 XHG=2100 YBD=431 YHG=400>not " XBD=2347 XHG=2193 YBD=430 YHG=396>treated " XBD=2453 XHG=2365 YBD=430 YHG=396>with " XBD=2526 XHG=2469 YBD=430 YHG=395>the" XBD=1562 XHG=1378 YBD=488 YHG=446>vitamin, " XBD=1682 XHG=1590 YBD=481 YHG=446>died " XBD=1810 XHG=1708 YBD=480 YHG=445>after " XBD=1944 XHG=1837 YBD=480 YHG=457>some " XBD=2019 XHG=1970 YBD=490 YHG=445>3? " XBD=2177 XHG=2044 YBD=480 YHG=446>hours. " XBD=2323 XHG=2230 YBD=479 YHG=445>This " XBD=2527 XHG=2346 YBD=479 YHG=443>difference" XBD=1459 XHG=1378 YBD=529 YHG=506>was " XBD=1630 XHG=1493 YBD=529 YHG=496>shown " XBD=1707 XHG=1661 YBD=529 YHG=498>to " XBD=1790 XHG=1739 YBD=529 YHG=495>be " XBD=2079 XHG=1823 YBD=538 YHG=493>statistically " XBD=2343 XHG=2112 YBD=539 YHG=493>significant, " XBD=2443 XHG=2376 YBD=527 YHG=493>but " XBD=2527 XHG=2469 YBD=527 YHG=493>the" XBD=1521 XHG=1377 YBD=588 YHG=544>figures " XBD=1643 XHG=1534 YBD=578 YHG=544>show " XBD=1747 XHG=1654 YBD=577 YHG=544>that " XBD=1829 XHG=1759 YBD=578 YHG=544>the " XBD=1997 XHG=1843 YBD=578 YHG=542>control " XBD=2134 XHG=2009 YBD=589 YHG=554>group " XBD=2227 XHG=2146 YBD=577 YHG=554>was " XBD=2329 XHG=2239 YBD=576 YHG=541>bled " XBD=2380 XHG=2339 YBD=576 YHG=545>to " XBD=2413 XHG=2392 YBD=575 YHG=554>a " XBD=2527 XHG=2425 YBD=575 YHG=552>some." XBD=1487 XHG=1376 YBD=627 YHG=593>what " XBD=1661 XHG=1508 YBD=638 YHG=596>greater " XBD=1822 XHG=1683 YBD=627 YHG=594>extent " XBD=1944 XHG=1842 YBD=627 YHG=592>than " XBD=2033 XHG=1963 YBD=626 YHG=591>the " XBD=2393 XHG=2054 YBD=626 YHG=590>vitamin-treated " XBD=2526 XHG=2410 YBD=636 YHG=602>group." XBD=1479 XHG=1427 YBD=676 YHG=641>In " XBD=1523 XHG=1499 YBD=676 YHG=653>a " XBD=1692 XHG=1545 YBD=676 YHG=642>second |>" XBD=1880 XHG=1715 YBD=687 YHG=644>paper,13 " XBD=2072 XHG=1906 YBD=677 YHG=641>GOVIER " XBD=2178 XHG=2098 YBD=675 YHG=641>and " XBD=2347 XHG=2204 YBD=676 YHG=640>GREER " XBD=2529 XHG=2369 YBD=685 YHG=641>reported" XBD=1470 XHG=1377 YBD=725 YHG=690>that " XBD=1814 XHG=1489 YBD=725 YHG=690>administration " XBD=1878 XHG=1833 YBD=725 YHG=690>of " XBD=2066 XHG=1892 YBD=724 YHG=691>vitamin " XBD=2137 XHG=2085 YBD=736 YHG=690>Bl " XBD=2292 XHG=2155 YBD=724 YHG=690>lowers " XBD=2376 XHG=2310 YBD=723 YHG=689>the " XBD=2482 XHG=2392 YBD=723 YHG=688>level " XBD=2531 XHG=2497 YBD=724 YHG=690>of" XBD=1612 XHG=1376 YBD=781 YHG=739>keto-acids, " XBD=1750 XHG=1633 YBD=784 YHG=750>sugar " XBD=1852 XHG=1770 YBD=774 YHG=739>and " XBD=1987 XHG=1868 YBD=773 YHG=738>lactic " XBD=2097 XHG=2007 YBD=774 YHG=739>acid " XBD=2156 XHG=2113 YBD=773 YHG=740>in " XBD=2248 XHG=2179 YBD=773 YHG=739>the " XBD=2382 XHG=2266 YBD=774 YHG=738>blood " XBD=2439 XHG=2398 YBD=772 YHG=737>of " XBD=2529 XHG=2451 YBD=784 YHG=738>dogs" XBD=1507 XHG=1377 YBD=823 YHG=788>which " XBD=1636 XHG=1531 YBD=825 YHG=789>have " XBD=1761 XHG=1660 YBD=823 YHG=788>been " XBD=1889 XHG=1785 YBD=823 YHG=787>bled. " XBD=1999 XHG=1944 YBD=822 YHG=788>As " XBD=2136 XHG=2023 YBD=822 YHG=788>these " XBD=2425 XHG=2161 YBD=822 YHG=785>observations " XBD=2529 XHG=2446 YBD=823 YHG=798>were" XBD=1494 XHG=1377 YBD=872 YHG=837>made " XBD=1554 XHG=1510 YBD=871 YHG=837>in " XBD=1739 XHG=1570 YBD=871 YHG=837>animals " XBD=1900 XHG=1754 YBD=882 YHG=837>locally " XBD=2209 XHG=1917 YBD=878 YHG=836>anaesthetised, " XBD=2323 XHG=2228 YBD=882 YHG=837>they " XBD=2530 XHG=2340 YBD=873 YHG=835>concluded" XBD=1470 XHG=1377 YBD=921 YHG=886>that " XBD=1563 XHG=1493 YBD=921 YHG=886>the " XBD=1792 XHG=1586 YBD=921 YHG=886>beneficial " XBD=1952 XHG=1815 YBD=921 YHG=886>effects " XBD=2162 XHG=1974 YBD=932 YHG=887>reported " XBD=2226 XHG=2184 YBD=920 YHG=887>in " XBD=2348 XHG=2248 YBD=921 YHG=886>their " XBD=2529 XHG=2369 YBD=932 YHG=886>previous" XBD=1502 XHG=1378 YBD=981 YHG=946>paper " XBD=1647 XHG=1529 YBD=970 YHG=935>could " XBD=1746 XHG=1672 YBD=970 YHG=939>not " XBD=1823 XHG=1773 YBD=970 YHG=936>be " XBD=1928 XHG=1850 YBD=970 YHG=936>due " XBD=1999 XHG=1955 YBD=970 YHG=938>to " XBD=2097 XHG=2026 YBD=970 YHG=936>the " XBD=2316 XHG=2125 YBD=981 YHG=935>complete " XBD=2384 XHG=2343 YBD=970 YHG=946>or " XBD=2532 XHG=2408 YBD=980 YHG=935>partial" XBD=1614 XHG=1378 YBD=1019 YHG=983>annulment " XBD=1683 XHG=1626 YBD=1030 YHG=985>by " XBD=1765 XHG=1695 YBD=1019 YHG=985>the " XBD=1951 XHG=1778 YBD=1020 YHG=985>vitamin " XBD=2008 XHG=1964 YBD=1020 YHG=984>of " XBD=2088 XHG=2017 YBD=1019 YHG=985>the " XBD=2274 XHG=2100 YBD=1019 YHG=984>harmful " XBD=2415 XHG=2286 YBD=1019 YHG=984>effects " XBD=2467 XHG=2427 YBD=1019 YHG=984>of " XBD=2530 XHG=2474 YBD=1021 YHG=985>the" XBD=1503 XHG=1379 YBD=1069 YHG=1034>ether. " XBD=1640 XHG=1557 YBD=1069 YHG=1034>The " XBD=1734 XHG=1658 YBD=1069 YHG=1034>rise " XBD=1795 XHG=1751 YBD=1069 YHG=1033>in " XBD=1930 XHG=1812 YBD=1069 YHG=1033>lactic " XBD=2038 XHG=1950 YBD=1069 YHG=1034>acid " XBD=2150 XHG=2058 YBD=1069 YHG=1046>seen " XBD=2271 XHG=2169 YBD=1069 YHG=1033>after " XBD=2530 XHG=2289 YBD=1081 YHG=1034>haemorrhage" XBD=1411 XHG=1378 YBD=1118 YHG=1084>is " XBD=1515 XHG=1441 YBD=1118 YHG=1087>not " XBD=1589 XHG=1545 YBD=1119 YHG=1083>of " XBD=1892 XHG=1616 YBD=1129 YHG=1083>significance ; " XBD=2015 XHG=1940 YBD=1119 YHG=1084>but " XBD=2116 XHG=2045 YBD=1119 YHG=1084>the " XBD=2387 XHG=2144 YBD=1129 YHG=1084>importance " XBD=2454 XHG=2414 YBD=1119 YHG=1083>of " XBD=2531 XHG=2476 YBD=1121 YHG=1085>the" XBD=1582 XHG=1378 YBD=1168 YHG=1134>increased " XBD=1822 XHG=1604 YBD=1178 YHG=1133>quantities " XBD=1887 XHG=1843 YBD=1168 YHG=1132>of " XBD=2128 XHG=1903 YBD=1168 YHG=1133>keto-acids " XBD=2181 XHG=2148 YBD=1167 YHG=1134>is " XBD=2310 XHG=2201 YBD=1168 YHG=1145>more " XBD=2481 XHG=2322 YBD=1168 YHG=1132>-difficult " XBD=2531 XHG=2497 YBD=1170 YHG=1137>to" XBD=1518 XHG=1379 YBD=1217 YHG=1194>assess. " XBD=1613 XHG=1571 YBD=1219 YHG=1183>It " XBD=1662 XHG=1628 YBD=1216 YHG=1183>is " XBD=1750 XHG=1678 YBD=1217 YHG=1185>not " XBD=1869 XHG=1767 YBD=1217 YHG=1183>clear " XBD=1978 XHG=1885 YBD=1228 YHG=1183>why " XBD=2106 XHG=1993 YBD=1217 YHG=1183>there " XBD=2265 XHG=2123 YBD=1217 YHG=1182>should " XBD=2328 XHG=2279 YBD=1217 YHG=1183>be " XBD=2366 XHG=2343 YBD=1218 YHG=1195>a " XBD=2531 XHG=2380 YBD=1228 YHG=1183>need for" XBD=1552 XHG=1379 YBD=1267 YHG=1232>vitamin " XBD=1630 XHG=1576 YBD=1279 YHG=1231>Bl " XBD=1759 XHG=1656 YBD=1266 YHG=1231>after " XBD=2056 XHG=1785 YBD=1278 YHG=1232>haemorrhage " XBD=2125 XHG=2082 YBD=1266 YHG=1232>in " XBD=2174 XHG=2150 YBD=1266 YHG=1243>a " XBD=2362 XHG=2200 YBD=1278 YHG=1232>healthy " XBD=2531 XHG=2386 YBD=1270 YHG=1232>well-fed" XBD=1483 XHG=1379 YBD=1327 YHG=1282>dog : " XBD=1679 XHG=1513 YBD=1317 YHG=1282>GOVIER " XBD=1773 XHG=1692 YBD=1316 YHG=1282>and " XBD=1934 XHG=1786 YBD=1317 YHG=1282>GREER " XBD=2158 XHG=1948 YBD=1328 YHG=1281>suggested " XBD=2262 XHG=2170 YBD=1317 YHG=1282>that " XBD=2445 XHG=2274 YBD=1328 YHG=1282>bleeding " XBD=2533 XHG=2456 YBD=1330 YHG=1294>may" XBD=1496 XHG=1379 YBD=1367 YHG=1332>lower " XBD=1565 XHG=1521 YBD=1366 YHG=1332>in " XBD=1699 XHG=1590 YBD=1367 YHG=1343>some " XBD=1814 XHG=1723 YBD=1377 YHG=1343>way " XBD=1907 XHG=1837 YBD=1366 YHG=1331>the " XBD=2106 XHG=1933 YBD=1366 YHG=1331>thiamin " XBD=2231 XHG=2129 YBD=1366 YHG=1331>level " XBD=2300 XHG=2257 YBD=1367 YHG=1331>of " XBD=2387 XHG=2320 YBD=1366 YHG=1332>the " XBD=2529 XHG=2409 YBD=1369 YHG=1333>tissues" XBD=1591 XHG=1380 YBD=1427 YHG=1380>generally. " XBD=1754 XHG=1644 YBD=1416 YHG=1381>More " XBD=1950 XHG=1772 YBD=1426 YHG=1380>recently " XBD=2171 XHG=1968 YBD=1416 YHG=1381>GOVIER 14 " XBD=2260 XHG=2188 YBD=1415 YHG=1381>has " XBD=2470 XHG=2280 YBD=1417 YHG=1382>described " XBD=2533 XHG=2485 YBD=1418 YHG=1382>his" XBD=1532 XHG=1381 YBD=1466 YHG=1431>studies " XBD=1607 XHG=1554 YBD=1465 YHG=1442>on " XBD=1697 XHG=1626 YBD=1465 YHG=1431>the " XBD=1977 XHG=1718 YBD=1476 YHG=1430>relationship " XBD=2178 XHG=1999 YBD=1465 YHG=1430>between " XBD=2268 XHG=2198 YBD=1465 YHG=1430>the " XBD=2433 XHG=2288 YBD=1476 YHG=1430>plasma " XBD=2533 XHG=2451 YBD=1466 YHG=1431>level" XBD=1426 XHG=1381 YBD=1516 YHG=1480>of " XBD=1630 XHG=1457 YBD=1515 YHG=1480>vitamin " XBD=1716 XHG=1664 YBD=1526 YHG=1480>Bl " XBD=1834 XHG=1752 YBD=1514 YHG=1479>and " XBD=1938 XHG=1868 YBD=1514 YHG=1480>the " XBD=2187 XHG=1972 YBD=1514 YHG=1480>resistance " XBD=2265 XHG=2222 YBD=1514 YHG=1483>to " XBD=2416 XHG=2301 YBD=1515 YHG=1480>shock " XBD=2532 XHG=2449 YBD=1517 YHG=1480>after" XBD=1663 XHG=1380 YBD=1575 YHG=1530>haemorrhage. " XBD=1781 XHG=1718 YBD=1564 YHG=1529>He " XBD=1932 XHG=1804 YBD=1564 YHG=1529>found " XBD=2047 XHG=1955 YBD=1564 YHG=1529>that " XBD=2116 XHG=2072 YBD=1564 YHG=1532>to " XBD=2307 XHG=2135 YBD=1575 YHG=1530>produce " XBD=2353 XHG=2330 YBD=1564 YHG=1542>a " XBD=2530 XHG=2375 YBD=1576 YHG=1542>perman." XBD=1495 XHG=1381 YBD=1625 YHG=1579>ently " XBD=1700 XHG=1528 YBD=1614 YHG=1579>lowered " XBD=2052 XHG=1734 YBD=1625 YHG=1578>blood-pressure " XBD=2187 XHG=2090 YBD=1625 YHG=1580>dogs " XBD=2368 XHG=2222 YBD=1625 YHG=1579>having " XBD=2423 XHG=2401 YBD=1614 YHG=1592>a " XBD=2531 XHG=2454 YBD=1626 YHG=1580>high" XBD=1725 XHG=1381 YBD=1675 YHG=1628>plasma-thiamin " XBD=1818 XHG=1752 YBD=1676 YHG=1629>(4y " XBD=1902 XHG=1833 YBD=1675 YHG=1640>per " XBD=1992 XHG=1921 YBD=1664 YHG=1630>100 " XBD=2120 XHG=2009 YBD=1664 YHG=1641>c.cm. " XBD=2219 XHG=2138 YBD=1663 YHG=1629>and " XBD=2373 XHG=2234 YBD=1673 YHG=1629>above) " XBD=2484 XHG=2389 YBD=1665 YHG=1621>must " XBD=2534 XHG=2495 YBD=1665 YHG=1630>be" XBD=1474 XHG=1381 YBD=1714 YHG=1678>bled " XBD=1597 XHG=1489 YBD=1714 YHG=1690>some " XBD=1709 XHG=1611 YBD=1726 YHG=1679>45% " XBD=1834 XHG=1724 YBD=1713 YHG=1690>more " XBD=1956 XHG=1854 YBD=1713 YHG=1679>than " XBD=2090 XHG=1974 YBD=1714 YHG=1679>those " XBD=2152 XHG=2110 YBD=1713 YHG=1679>in " XBD=2293 XHG=2165 YBD=1713 YHG=1679>which " XBD=2379 XHG=2312 YBD=1713 YHG=1679>the " XBD=2533 XHG=2392 YBD=1725 YHG=1679>plasma-" XBD=1555 XHG=1382 YBD=1764 YHG=1729>thiamin " XBD=1606 XHG=1572 YBD=1763 YHG=1729>is " XBD=1700 XHG=1623 YBD=1764 YHG=1728>low " XBD=1862 XHG=1717 YBD=1776 YHG=1729>(0-2y). " XBD=2032 XHG=1901 YBD=1764 YHG=1728>When " XBD=2144 XHG=2046 YBD=1774 YHG=1729>dogs " XBD=2261 XHG=2161 YBD=1763 YHG=1740>were " XBD=2442 XHG=2277 YBD=1764 YHG=1728>fortified " XBD=2532 XHG=2456 YBD=1764 YHG=1729>with" XBD=1559 XHG=1383 YBD=1814 YHG=1779>vitamin " XBD=1653 XHG=1600 YBD=1825 YHG=1778>Bl " XBD=1827 XHG=1694 YBD=1813 YHG=1777>before " XBD=2062 XHG=1867 YBD=1824 YHG=1777>bleeding, " XBD=2210 XHG=2107 YBD=1813 YHG=1778>their " XBD=2531 XHG=2250 YBD=1825 YHG=1775>blood-pressure" XBD=1533 XHG=1384 YBD=1863 YHG=1828>tended " XBD=1590 XHG=1545 YBD=1863 YHG=1831>to " XBD=1742 XHG=1603 YBD=1862 YHG=1832>return " XBD=1799 XHG=1754 YBD=1862 YHG=1831>to " XBD=1967 XHG=1812 YBD=1863 YHG=1828>normal " XBD=2085 XHG=1981 YBD=1863 YHG=1827>after " XBD=2375 XHG=2098 YBD=1873 YHG=1828>haemorrhage, " XBD=2532 XHG=2389 YBD=1863 YHG=1828>whereas" XBD=1554 XHG=1386 YBD=1912 YHG=1877>animals " XBD=1762 XHG=1577 YBD=1912 YHG=1877>deficient " XBD=1826 XHG=1784 YBD=1912 YHG=1878>in " XBD=2023 XHG=1850 YBD=1912 YHG=1877>vitamin " XBD=2102 XHG=2048 YBD=1924 YHG=1877>Bi " XBD=2336 XHG=2120 YBD=1923 YHG=1877>developed " XBD=2533 XHG=2352 YBD=1923 YHG=1878>persistent" XBD=1654 XHG=1386 YBD=1973 YHG=1928>hypotension " XBD=1775 XHG=1677 YBD=1963 YHG=1939>soon " XBD=1900 XHG=1798 YBD=1962 YHG=1926>after " XBD=1993 XHG=1923 YBD=1962 YHG=1928>the " XBD=2095 XHG=2015 YBD=1962 YHG=1927>loss " XBD=2162 XHG=2118 YBD=1962 YHG=1926>of " XBD=2295 XHG=2181 YBD=1962 YHG=1925>small " XBD=2485 XHG=2316 YBD=1962 YHG=1929>amounts " XBD=2536 XHG=2503 YBD=1961 YHG=1926>of" XBD=1519 XHG=1386 YBD=2012 YHG=1977>blood. " XBD=1656 XHG=1572 YBD=2012 YHG=1977>The " XBD=1876 XHG=1674 YBD=2012 YHG=1977>incidence " XBD=1940 XHG=1895 YBD=2012 YHG=1976>of " XBD=2160 XHG=1953 YBD=2012 YHG=1975>intestinal " XBD=2437 XHG=2178 YBD=2023 YHG=1976>haemorrhage " XBD=2533 XHG=2452 YBD=2011 YHG=1975>after" XBD=1569 XHG=1386 YBD=2074 YHG=2027>bleeding " XBD=1670 XHG=1589 YBD=2063 YHG=2039>was " XBD=1809 XHG=1689 YBD=2063 YHG=2028>much " XBD=1983 XHG=1829 YBD=2073 YHG=2030>greater " XBD=2044 XHG=2002 YBD=2061 YHG=2027>in " XBD=2232 XHG=2064 YBD=2062 YHG=2026>animals " XBD=2426 XHG=2251 YBD=2062 YHG=2026>deficient " XBD=2480 XHG=2442 YBD=2062 YHG=2027>in " XBD=2533 XHG=2493 YBD=2074 YHG=2026>Bl" XBD=1488 XHG=1385 YBD=2113 YHG=2079>than " XBD=1550 XHG=1508 YBD=2112 YHG=2077>in " XBD=1686 XHG=1570 YBD=2112 YHG=2078>those " XBD=1804 XHG=1707 YBD=2112 YHG=2077>with " XBD=1921 XHG=1824 YBD=2122 YHG=2077>high " XBD=2284 XHG=1941 YBD=2123 YHG=2076>plasma-thiamin " XBD=2440 XHG=2303 YBD=2118 YHG=2076>levels; " XBD=2533 XHG=2461 YBD=2117 YHG=2075>and," XBD=1537 XHG=1386 YBD=2172 YHG=2127>finally, " XBD=1626 XHG=1556 YBD=2161 YHG=2127>the " XBD=1987 XHG=1643 YBD=2172 YHG=2127>plasma-thiamin " XBD=2088 XHG=2000 YBD=2162 YHG=2138>rose " XBD=2150 XHG=2106 YBD=2161 YHG=2138>as " XBD=2236 XHG=2166 YBD=2162 YHG=2127>the " XBD=2534 XHG=2253 YBD=2172 YHG=2125>blood-pressure" XBD=1467 XHG=1387 YBD=2213 YHG=2176>fell. " XBD=1646 XHG=1520 YBD=2211 YHG=2177>These " XBD=1931 XHG=1665 YBD=2223 YHG=2177>experiments " XBD=2055 XHG=1951 YBD=2211 YHG=2188>seem " XBD=2127 XHG=2083 YBD=2211 YHG=2179>to " XBD=2264 XHG=2155 YBD=2211 YHG=2176>show " XBD=2379 XHG=2289 YBD=2210 YHG=2176>that " XBD=2535 XHG=2395 YBD=2210 YHG=2174>vitamin" XBD=1441 XHG=1388 YBD=2274 YHG=2227>Bl " XBD=1652 XHG=1457 YBD=2261 YHG=2226>increases " XBD=1739 XHG=1668 YBD=2262 YHG=2227>the " XBD=1969 XHG=1754 YBD=2261 YHG=2227>resistance " XBD=2030 XHG=1986 YBD=2261 YHG=2225>of " XBD=2212 XHG=2044 YBD=2261 YHG=2225>animals " XBD=2273 XHG=2229 YBD=2261 YHG=2229>to " XBD=2356 XHG=2289 YBD=2260 YHG=2225>the " XBD=2490 XHG=2371 YBD=2260 YHG=2224>effects " XBD=2537 XHG=2504 YBD=2259 YHG=2222>of" XBD=1672 XHG=1389 YBD=2322 YHG=2277>haemorrhage, " XBD=1791 XHG=1710 YBD=2311 YHG=2275>and " XBD=1993 XHG=1827 YBD=2311 YHG=2276>GOVIER " XBD=2222 XHG=2027 YBD=2311 YHG=2276>discusses " XBD=2362 XHG=2258 YBD=2310 YHG=2287>some " XBD=2535 XHG=2393 YBD=2321 YHG=2273>possible" XBD=1680 XHG=1389 YBD=2373 YHG=2326>explanations. " XBD=1907 XHG=1734 YBD=2372 YHG=2326>Hepatic " XBD=2263 XHG=1951 YBD=2372 YHG=2325>glycogenolysis " XBD=2381 XHG=2305 YBD=2361 YHG=2325>and " XBD=2534 XHG=2419 YBD=2371 YHG=2325>hyper-" XBD=1596 XHG=1389 YBD=2423 YHG=2376>glycaemia " XBD=1719 XHG=1615 YBD=2412 YHG=2375>after " XBD=2009 XHG=1738 YBD=2421 YHG=2376>haemorrhage " XBD=2110 XHG=2029 YBD=2411 YHG=2375>will " XBD=2301 XHG=2128 YBD=2410 YHG=2376>increase " XBD=2386 XHG=2320 YBD=2410 YHG=2376>the " XBD=2535 XHG=2407 YBD=2420 YHG=2373>quanti-" XBD=1465 XHG=1389 YBD=2461 YHG=2427>ties " XBD=1527 XHG=1483 YBD=2461 YHG=2425>of " XBD=1762 XHG=1539 YBD=2461 YHG=2426>keto-acids " XBD=1982 XHG=1778 YBD=2471 YHG=2426>produced " XBD=2040 XHG=1997 YBD=2460 YHG=2426>in " XBD=2126 XHG=2056 YBD=2460 YHG=2426>the " XBD=2416 XHG=2141 YBD=2470 YHG=2425>intermediary " XBD=2536 XHG=2431 YBD=2471 YHG=2427>stages" XBD=1435 XHG=1392 YBD=2510 YHG=2475>of " XBD=1776 XHG=1484 YBD=2520 YHG=2475>carbohydrate " XBD=2093 XHG=1825 YBD=2517 YHG=2475>metabolism, " XBD=2205 XHG=2142 YBD=2510 YHG=2474>for " XBD=2323 XHG=2254 YBD=2511 YHG=2475>the " XBD=2536 XHG=2371 YBD=2520 YHG=2474>complete" XBD=1600 XHG=1392 YBD=2560 YHG=2525>oxidation " XBD=1661 XHG=1617 YBD=2560 YHG=2524>of " XBD=1804 XHG=1675 YBD=2559 YHG=2525>which " XBD=2024 XHG=1820 YBD=2560 YHG=2525>increased " XBD=2259 XHG=2042 YBD=2570 YHG=2524>quantities " XBD=2319 XHG=2276 YBD=2560 YHG=2524>of " XBD=2484 XHG=2331 YBD=2559 YHG=2524>vitamin " XBD=2537 XHG=2497 YBD=2569 YHG=2523>Bl" XBD=1472 XHG=1391 YBD=2610 YHG=2574>will " XBD=1542 XHG=1492 YBD=2610 YHG=2575>be " XBD=1726 XHG=1563 YBD=2609 YHG=2574>needed. " XBD=1831 XHG=1780 YBD=2608 YHG=2574>In " XBD=1956 XHG=1851 YBD=2609 YHG=2574>their " XBD=2147 XHG=1978 YBD=2609 YHG=2575>absence " XBD=2237 XHG=2168 YBD=2610 YHG=2574>the " XBD=2488 XHG=2258 YBD=2610 YHG=2573>metabolism " XBD=2540 XHG=2506 YBD=2608 YHG=2570>of" XBD=1462 XHG=1391 YBD=2660 YHG=2624>the " XBD=1803 XHG=1479 YBD=2670 YHG=2623>predominantly " XBD=2301 XHG=1822 YBD=2670 YHG=2624>carbohydrate-burning " XBD=2448 XHG=2317 YBD=2659 YHG=2624>tissues " XBD=2537 XHG=2463 YBD=2668 YHG=2632>may" XBD=1443 XHG=1392 YBD=2708 YHG=2673>be " XBD=1729 XHG=1466 YBD=2719 YHG=2674>interrupted, " XBD=1946 XHG=1753 YBD=2720 YHG=2673>resulting " XBD=2012 XHG=1969 YBD=2708 YHG=2675>in " XBD=2290 XHG=2034 YBD=2719 YHG=2674>impairment " XBD=2355 XHG=2313 YBD=2709 YHG=2673>of " XBD=2535 XHG=2372 YBD=2710 YHG=2673>function." XBD=1476 XHG=1392 YBD=2758 YHG=2723>The " XBD=1697 XHG=1490 YBD=2758 YHG=2722>intestinal " XBD=1979 XHG=1710 YBD=2769 YHG=2723>haemorrhage " XBD=2089 XHG=1994 YBD=2768 YHG=2735>may " XBD=2154 XHG=2103 YBD=2758 YHG=2724>be " XBD=2246 XHG=2168 YBD=2758 YHG=2723>due " XBD=2302 XHG=2259 YBD=2758 YHG=2727>to " XBD=2536 XHG=2317 YBD=2759 YHG=2723>constriction" XBD=1437 XHG=1393 YBD=2807 YHG=2772>of " XBD=1521 XHG=1451 YBD=2807 YHG=2773>the " XBD=1698 XHG=1538 YBD=2818 YHG=2772>hepatic " XBD=1870 XHG=1716 YBD=2814 YHG=2773>veins,15 " XBD=1933 XHG=1889 YBD=2808 YHG=2784>or " XBD=1995 XHG=1950 YBD=2807 YHG=2776>to " XBD=2190 XHG=2017 YBD=2819 YHG=2772>swelling " XBD=2255 XHG=2212 YBD=2807 YHG=2772>of " XBD=2339 XHG=2272 YBD=2808 YHG=2773>the " XBD=2536 XHG=2358 YBD=2819 YHG=2770>polygonal" XBD=1486 XHG=1395 YBD=2856 YHG=2821>cells " XBD=1543 XHG=1499 YBD=2857 YHG=2821>of " XBD=1620 XHG=1551 YBD=2856 YHG=2822>the liver .6 " XBD=1993 XHG=1824 YBD=2868 YHG=2821>Against " XBD=2263 XHG=2005 YBD=2857 YHG=2823>constriction " XBD=2320 XHG=2276 YBD=2857 YHG=2822>of " XBD=2394 XHG=2329 YBD=2857 YHG=2823>the " XBD=2536 XHG=2406 YBD=2869 YHG=2822>hepatic" XBD=1520 XHG=1395 YBD=2912 YHG=2871>veins, " XBD=1715 XHG=1542 YBD=2906 YHG=2871>vitamin " XBD=1788 XHG=1735 YBD=2917 YHG=2870>Bl " XBD=1939 XHG=1808 YBD=2917 YHG=2872>might " XBD=2010 XHG=1959 YBD=2906 YHG=2871>be " XBD=2076 XHG=2031 YBD=2905 YHG=2870>of " XBD=2242 XHG=2094 YBD=2906 YHG=2871>benefit " XBD=2317 XHG=2263 YBD=2917 YHG=2871>by " XBD=2535 XHG=2336 YBD=2916 YHG=2872>reinforcing" XBD=1770 XHG=1396 YBD=2965 YHG=2919>acetylcholine-if " XBD=1934 XHG=1788 YBD=2955 YHG=2920>indeed " XBD=2037 XHG=1955 YBD=2955 YHG=2920>this " XBD=2133 XHG=2059 YBD=2955 YHG=2920>has " XBD=2179 XHG=2155 YBD=2955 YHG=2933>a " XBD=2343 XHG=2203 YBD=2956 YHG=2921>dilator " XBD=2481 XHG=2363 YBD=2956 YHG=2921>action " XBD=2536 XHG=2498 YBD=2956 YHG=2931>on" XBD=1519 XHG=1394 YBD=3004 YHG=2969>them. " XBD=1627 XHG=1574 YBD=3004 YHG=2969>Or " XBD=1677 XHG=1642 YBD=3004 YHG=2970>it " XBD=1820 XHG=1692 YBD=3015 YHG=2969>might " XBD=1941 XHG=1836 YBD=3004 YHG=2970>have " XBD=2065 XHG=1957 YBD=3005 YHG=2981>some " XBD=2301 XHG=2080 YBD=3016 YHG=2971>protective " XBD=2485 XHG=2314 YBD=3006 YHG=2970>influence " XBD=2536 XHG=2498 YBD=3006 YHG=2980>on" XBD=1464 XHG=1394 YBD=3053 YHG=3019>the " XBD=1580 XHG=1481 YBD=3053 YHG=3018>liver " XBD=1703 XHG=1600 YBD=3054 YHG=3018>cells." XBD=1589 XHG=1446 YBD=3102 YHG=3067>Before " XBD=1675 XHG=1605 YBD=3103 YHG=3069>the " XBD=1780 XHG=1691 YBD=3102 YHG=3072>true " XBD=1915 XHG=1796 YBD=3103 YHG=3068>value " XBD=1975 XHG=1931 YBD=3103 YHG=3067>of " XBD=2159 XHG=1987 YBD=3103 YHG=3068>vitamin " XBD=2227 XHG=2174 YBD=3114 YHG=3069>Bl " XBD=2283 XHG=2242 YBD=3103 YHG=3069>in " XBD=2411 XHG=2298 YBD=3104 YHG=3069>shock " XBD=2487 XHG=2425 YBD=3105 YHG=3081>can " XBD=2536 XHG=2498 YBD=3105 YHG=3070>be" XBD=1574 XHG=1396 YBD=3151 YHG=3117>assessed " XBD=1670 XHG=1599 YBD=3151 YHG=3117>the " XBD=1805 XHG=1696 YBD=3152 YHG=3117>work " XBD=1877 XHG=1833 YBD=3152 YHG=3117>of |>" XBD=2066 XHG=1900 YBD=3152 YHG=3116>GoviER " XBD=2174 XHG=2093 YBD=3152 YHG=3118>and |>" XBD=2346 XHG=2201 YBD=3153 YHG=3118>GREER " XBD=2437 XHG=2367 YBD=3153 YHG=3117>will " XBD=2536 XHG=2459 YBD=3154 YHG=3117>need" XBD=1689 XHG=1399 YBD=3201 YHG=3165>confirmation. " XBD=1798 XHG=1742 YBD=3201 YHG=3166>At " XBD=1926 XHG=1823 YBD=3208 YHG=3167>best, " XBD=2126 XHG=1953 YBD=3201 YHG=3167>vitamin |>" XBD=2204 XHG=2151 YBD=3213 YHG=3167>Bl " XBD=2304 XHG=2231 YBD=3202 YHG=3178>can " XBD=2373 XHG=2327 YBD=3202 YHG=3167>be " XBD=2477 XHG=2396 YBD=3213 YHG=3166>only " XBD=2535 XHG=2496 YBD=3203 YHG=3178>an" XBD=1596 XHG=1397 YBD=3258 YHG=3214>adjuvant " XBD=1659 XHG=1615 YBD=3249 YHG=3218>to " XBD=1936 XHG=1678 YBD=3256 YHG=3214>transfusion, " XBD=2038 XHG=1957 YBD=3249 YHG=3215>and " XBD=2192 XHG=2057 YBD=3249 YHG=3214>before " XBD=2263 XHG=2210 YBD=3250 YHG=3216>its " XBD=2425 XHG=2281 YBD=3260 YHG=3216>general " XBD=2496 XHG=2440 YBD=3251 YHG=3228>use " XBD=2535 XHG=2510 YBD=3250 YHG=3216>is" XBD=1697 XHG=1399 YBD=3308 YHG=3263>contemplated " XBD=1905 XHG=1735 YBD=3298 YHG=3275>answers " XBD=2054 XHG=1944 YBD=3298 YHG=3266>must " XBD=2142 XHG=2092 YBD=3297 YHG=3264>be " XBD=2304 XHG=2179 YBD=3298 YHG=3263>found " XBD=2379 XHG=2338 YBD=3298 YHG=3268>to " XBD=2534 XHG=2414 YBD=3300 YHG=3263>several" XBD=1617 XHG=1400 YBD=3357 YHG=3312>questions. " XBD=1769 XHG=1661 YBD=3356 YHG=3312>Why " XBD=1814 XHG=1780 YBD=3345 YHG=3312>is " XBD=1939 XHG=1826 YBD=3346 YHG=3312>there " XBD=1975 XHG=1952 YBD=3346 YHG=3323>a " XBD=2143 XHG=1989 YBD=3357 YHG=3314>greater " XBD=2256 XHG=2156 YBD=3347 YHG=3312>need " XBD=2326 XHG=2267 YBD=3347 YHG=3312>for " XBD=2486 XHG=2338 YBD=3347 YHG=3313>vitamin " XBD=2533 XHG=2494 YBD=3358 YHG=3313>Bl

13. J. Pharmacol. 1941, 72, 321.14. Govier, W. M. Ibid, 1943, 77, 40. 15. Lamson, P. Ibid, 1920, 16, 125.16. Bainbridge, F. A. and Trevan, J. W. J. Physiol. 1917, 16, 460.