SCIENTIFIC WRITING - clevelandclinic.org · Synopsis of Writing Project 2 73. SI 2015 Scientific Writing Projects. doc Ashok Agarwal, PhD Professor, Lerner College of Medicine Director,

71. Scientific Writing Projects Insert Page 2015.doc

SCIENTIFIC WRITING

NO. WRITING PROJECT TOPIC NO. OF INTERNS DEADLINE

BOOK 1

PROJECT 1OVERVIEW & SOURCES OF REACTIVE OXYGEN

SPECIES IN THE REPRODUCTIVE SYSTEM3 31-Jul-15

PROJECT 2METHODS TO MEASURE REACTIVE OXYGEN

SPECIES (AND TAC) IN THE REPRODUCTIVE SYSTEM2 31-Jul-15

PROJECT 3PHYSIOLOGICAL ROLE OF REACTIVE OXYGEN

SPECIES IN THE REPRODUCTIVE SYSTEM2 31-Jul-15

PROJECT 4NEGATIVE EFFECTS OF OXIDATIVE STRESS IN THE

REPRODUCTIVE SYSTEM2 31-Jul-15

PROJECT 5EXTRINSIC FACTORS INDUCING OXIDATIVE STRESS

IN THE REPRODUCTIVE SYSTEM2 31-Jul-15

PROJECT 6

PATHOLOGICAL ROLE OF REACTIVE OXYGEN

SPECIES IN COMPLICATIONS/DISEASES RELATED

TO THE REPRODUCTIVE SYSTEM

3 31-Jul-15

PROJECT 7THERAPEUTIC ROLE OF ANTIOXIDANTS (AOX) IN

THE TREATMENT OF INFERTILITY 2 31-Jul-15

BOOK 2

PROJECT 8 CARDIOVASCULAR DISEASES 2 31-Jul-15

PROJECT 9 CANCERS 2 31-Jul-15

PROJECT 10 DIABETES 2 31-Jul-15

PROJECT 11 OBESITY 2 31-Jul-15

PROJECT 12 PITUITARY, THYROID AND ADRENAL DISORDERS 2 31-Jul-15

PROJECT 13 MENTAL HEALTH 2 31-Jul-15

PROJECT 14 GASTROINTESTINAL DISEASES 2 31-Jul-15

Ashok Agarwal, PhD

Gulfam Ahmad, PhD

Sajal Gupta, MD

Rakesh Sharma, PhD

NON-COMMUNICABLE DISEASES AND THEIR IMPACT ON FERTILITY

Sajal Gupta, MD

Avraham Harlev, MD

Gulfam Ahmad, PhD

Rakesh Sharma, PhD

Sajal Gupta, MD

Stefan du Plessis, PhD

Gulfam Ahmad, PhD


Gulfam Ahmad, PhD

Ashok Agarwal, PhD

Gulfam Ahmad, PhD


Avraham Harlev, MD

Gulfam Ahmad, PhD

INDEX OF SCIENTIFIC WRITING PROJECTS

OXIDATIVE STRESS IN HUMAN REPRODUCTION – SHEDDING LIGHT ON A COMPLICATED PHENOMENON

MENTOR(S)

Ashok Agarwal, PhD

Gulfam Ahmad, PhD

Luna Samanta, PhD

Damayanthi Durairajanayagam, PhD

Ashok Agarwal, PhD

Rakesh Sharma, PhD

Anthony Kashou, BS

Sajal Gupta, MD

Avraham Harlev, MD

Ashok Agarwal, PhD


Avraham Harlev, MD

Ashok Agarwal, PhD

Rakesh Sharma, PhD

Luna Samanta, PhD

Ahmet Ayaz, MSc

Ashok Agarwal, PhD


Avraham Harlev, MD

Ashok Agarwal, PhD


Sajal Gupta, MD

Damayanthi Durairajanayagam, PhD

72. Index of Scientific Writing Projects

Synopsis of Writing Project

1 73. SI 2015 Scientific Writing Projects. doc

8th ANNUAL SUMMER MENTORSHIP IN

REPRODUCTIVE MEDICINE

CENTER FOR REPRODUCTIVE MEDICINE

CLEVELAND CLINIC

SYNOPSIS OF SCIENTIFIC WRITING PROJECTS

JUNE 15th – JULY 31st, 2015



Ashok Agarwal, PhD

Professor, Lerner College of Medicine

Director, Center for Reproductive Medicine

Director, Andrology Center

Cleveland Clinic

E-mail: [email protected]

Tel: 216-444-9485 / Mobile: 216-312-5829

1. OXIDATIVE STRESS IN HUMAN REPRODUCTION – SHEDDING LIGHT ON A COMPLICATED

PHENOMENON

Authors : Ashok Agarwal, PhD; Damayanthi Durairajanayagam, PhD; Gulfam Ahmad, PhD; Stefan

Du Plessis, PhD; Luna Samanta, PhD; Rakesh Sharma, PhD; Avraham Harlev, MD; Ahmet Ayaz, MS;

Anthony Kashou, BS

Background:

Pro-oxidants such as reactive oxygen species (ROS) and reactive nitrogen species are produced

as byproducts of normal physiologic processes and cellular metabolism. These are required at

physiological levels for the normal functioning of both the male and female reproductive system.

Endogenous antioxidants oppose the over production and subsequent effects of pro-oxidants in order to

maintain the intracellular homeostasis. An imbalance between pro and anti-oxidants levels may result

into oxidative stress which may lead to the development of a number of pathological conditions. This

review will discuss the generation and determination of ROS levels in body fluid/tissues. The

physiological roles of ROS as well as its negative effects on the human reproductive processes will be

emphasized. Further, the multiple extrinsic factors that could induce oxidative stress in the reproductive

system will be discussed. This will be followed by a description of the various clinical pathologies related

to the reproductive system that arise from or produce oxidative stress, both in the male and female.

Next, the use of antioxidants as a therapeutic measure to keep ROS levels in check will be highlighted,

by describing the outcome of various clinical studies involving antioxidant supplementation in infertile

patients. Infertility is a global disease that affects 15-25% of all couples, and oxidative stress arising from

mailto:[email protected]



a multitude of sources has been implicated as one of the major contributing factors to the decline in

human fertility.

Key Words: Reactive oxygen species, Oxidative stress, Male Infertility, Female Infertility, Human

Reproduction, Antioxidant Therapy

Significance:

This review will be addressing a current and pertinent issue and will provide an up to date background

on the significance of ROS in human reproduction.

Outline: Chapter 1: Introduction and Sources of Reactive Oxygen Species in the Reproductive System

Infertility

Redox Reactions

Haber-Weiss reaction

Fenton reaction

Electron transport chain

Reactive Oxygen Species (ROS)

Characteristics

Reactive Nitrogen Species (RNS)

Characteristics

Antioxidants

Enzymatic

Non-enzymatic

Oxidative Stress (OS) Sources of Reactive Oxygen Species in the Reproductive System In the Male

Endogenous Sources of OS in Seminal Plasma

Immature Sperm (excess residual cytoplasm)

Leukocytospermia (peroxidase-positive leukocytes) In the Female

Endogenous Sources of OS in Follicular Fluid, Tubal Fluid, Oocyte, Embryo, Endometrium, Placenta Chapter 2: Methods to Measure Reactive Oxygen Species (and TAC) in the Reproductive System

Microscopy and Stain

Chemiluminescence

Epifluorescence Microscopy

Flow Cytometry

Total Antioxidant Capacity (TAC) Assay



ELISA

Immunohistochemistry, and Western Blotting Chapter 3: Physiological Role of Reactive Oxygen Species in the Reproductive System In the Male

Motility

Capacitation

Hyperactivation

Acrosome reaction

Sperm-oocyte fusion In the Female

Folliculogenesis

Oogenesis

Corpus luteum apoptosis

Steroidogenesis

Endometrial Cycle Chapter 4: Negative Effects of Oxidative Stress in the Reproductive System In the Male

Lipid peroxidation

Sperm mitochondrial membrane potential

Sperm DNA Damage

Acrosome Reaction

Sperm-oocyte fusion

Apoptosis In the Female

Lipid peroxidation/cellular damage

DNA Damage

Protein Oxidation Chapter 5: Extrinsic Factors Inducing Oxidative Stress in the Reproductive System In the Male

Diet (obesity/malnutrition)

Alcohol

Smoking / Tobacco Use

Recreational Drug Use

Environmental pollution

Radiation

Spinal Cord Injury

Depression In the Female

Diet (obesity/malnutrition)

Alcohol

Smoking / Tobacco Use

Recreational Drug Use



Environmental pollution

Radiation Chapter 6: Pathological Role of Reactive Oxygen Species in Complications/Diseases Related to the Reproductive System In the Male

Semen quality

Varicocele

Cryptorchidism

Torsion of spermatic cord

Unexplained infertility In the Female

Pregnancy complications

Spontaneous abortion

Pregnancy loss

Preeclampsia

Menopause

Polycystic ovary syndrome

Endometriosis

Unexplained infertility

Gestational diabetes mellitus (GDM) Chapter 7: Therapeutic Role of Antioxidants (AOX) in the Treatment of Infertility In the Male

Individual AOX Treatments

Combined AOX Treatments In the Female

Individual AOX Treatments

Combined AOX Treatments Chapter 8: Compendium of Oxidative Stress Studies Published by the Cleveland Clinic Chapter 9: Conclusion

Key findings

Five year view

Take Home Message

Literature review:

A preliminary literature search has been done using resources of the Cleveland Clinic Alumni Library. An

exhaustive literature review needs to be conducted before the manuscript is written.



Suggested reading:

1. Agarwal A, Virk G, Ong C, du Plessis SS. Effect of oxidative stress on male reproduction. World J

Mens Health. 2014 Apr;32(1):1-17. doi: 10.5534/wjmh.2014.32.1.1.

2. Agarwal A, Saleh RA, Bedaiwy MA. Role of reactive oxygen species in the pathophysiology of

human reproduction. Fertil Steril. 2003 Apr;79(4):829-43.

3. Sharma RK, Agarwal A. Role of reactive oxygen species in male infertility. Urology. 1996

Dec;48(6):835-50.

4. Agarwal A, Aponte-Mellado A, Premkumar BJ, Shaman A, Gupta S. The effects of oxidative

stress on female reproduction: a review. Reprod Biol Endocrinol. 2012 Jun 29;10:49.

5. Agarwal A, Said TM, Bedaiwy MA, Banerjee J, Alvarez JG. Oxidative stress in an assisted

reproductive techniques setting. Fertil Steril. 2006 Sep;86(3):503-12.

6. Doshi SB, Agarwal A. The role of oxidative stress in menopause. J Midlife Health. 2013

Jul;4(3):140-6.

7. Agarwal A, Gupta S, Sharma RK. Role of oxidative stress in female reproduction. Reprod Biol

Endocrinol. 2005 Jul 14;3:28

8. Agarwal A, Shyam S, Alamaneni R. Free radicals and male reproduction. J Indian Med Assoc

2011; 109:184-187.

9. Chandra, A, Surti, N, Kesavan, S, Agarwal, A. Significance of oxidative stress in human

reproduction. Arch of Med Sci. 2009; 5, 1A: S28-S42.

10. Agarwal A, Makker K, Sharma R. Clinical relevance of oxidative stress in male factor infertility: an

update. Am J Reprod Immunol 2008; 59: 2–11.

11. Agarwal A, Sekhon LH. The role of antioxidant therapy in the treatment of male infertility. Hum

Fert (Camb) 2010; 13(3): 217-225.

12. Aitken RJ, Krausz C. Oxidative stress, DNA damage and the Y chromosome. Reproduction 2001;

122(4):497-506.

13. Aitken RJ, Roman SD. Antioxidant systems and oxidative stress in the testes. Oxid Med Cell

Longev. 2008. 1(1): 15–24.

14. Kefer JC, Agarwal A, Sabanegh E. Role of antioxidants in the treatment of male infertility. Int J

Urol. 2009; 16(5): 449-457.

15. Tremellen K. Oxidative stress and male infertility--a clinical perspective. Hum Reprod Update

2008; 14(3):243-58.

http://www.ncbi.nlm.nih.gov/pubmed/8973665



Intended audience:

This authoritative review will be of particular interest to reproductive biologists and clinicians dealing

with the complications of oxidative stress in their research and medical practice.

Book Chapters:

In: Oxidative Stress in Human Reproduction – Shedding Light on a Complicated Phenomenon,

SpringerBriefs in Reproductive Medicine, Springer.

Deadline:

July 31, 2015




Gulfam Ahmad, PhD

Fulbright Fellows in Andrology

Center for Reproductive Medicine

Cleveland Clinic

E-mail: [email protected]; [email protected]

Tel: 216-444-4402 / Mobile: 216-387-7932 (SSDP)

Tel: 216-444-4402 / Mobile: 216-507-6445 (AG)

2. NON-COMMUNICABLE DISEASES AND THEIR IMPACT ON FERTILITY

Authors: Stefan Du Plessis, PhD; Gulfam Ahmad, PhD; Ashok Agarwal, PhD; Sajal Gupta, MD;

Avraham Harlev, MD; Rakesh Sharma, PhD

Background:

Fertility is on the decrease and from the literature it is known that lifestyle factors (e.g.) smoking

and obesity) as well as communicable diseases impact negatively on both male and female fertility

parameters, but very little information is currently available on the contributing effects of Non-

communicable diseases (NCD’s) on fertility status.

NCD’s is classified as a medical condition or disease that can be defined as non-infectious and

non-transmissible among people. NCD’s can refer to chronic diseases, which last for long periods of time

and usually progress slowly. However, it can at times result in rapid deaths. NCD’s are therefore

predominantly distinguished only by their non-infectious cause, and not necessarily by their duration.

According to the World Health Organization (WHO) the 4 main types of non-communicable

diseases are: Cardiovascular diseases (e.g. heart attacks and stroke), Cancers, Chronic respiratory

diseases (such as chronic obstructed pulmonary disease and asthma) and Diabetes. Other important

NCD’s also include chronic kidney disease, mental disorders, epilepsy, genetic diseases and many more

environmental diseases.

Risk factors such as a person's background, lifestyle and environment are known to increase the

likelihood of certain NCDs. Risk factors include:





Modifiable behavioral risk factors - Tobacco use, physical inactivity, unhealthy diet (e.g. excess

salt intake) and the harmful use of alcohol.

Metabolic/physiological risk factors - raised blood pressure, overweight/obesity, hyperglycemia

(high blood glucose levels) and hyperlipidemia (high levels of fat in the blood).

The question that remains to be asked is: What is the impact of NCD’s on the male/female

reproductive system and their fertility?

The aim of this Springer Brief Manuscript would be to discuss selected NCD’s and report on their

direct and related effects on reproduction. Furthermore we will highlight the mechanisms of action via

which these NCD’s influence reproduction and also as to how the impact can be lessened through

treatment and reducing of risk factors.

Key Words: Non-communicable disease, Infertility, Cardiovascular diseases, Cancer, Mental Health,

Endocrine and Metabolic disorders, Gastrointestinal diseases, Diabetes, Spermatozoa

Significance:

This compendium of topics will explore and provide up to date information on the influence and impact

that non-communicable diseases have on fertility status.

Outline:

Chapter 1: Introduction

What area non-communicable diseases (NCDs)

Literary background and incidence

Interplay of NCDs and male fertility

Rationale

Diseases to be discussed: Justification Chapter 2: Cardiovascular Diseases In the Male

Types o Ischemic heart disease o Stroke o Hypertension o Hypercholesterolemia o Dyslipidemia

Direct Impact on Male Fertility



o Impact on spermatogenesis o Impact on sperm functions o Erectile dysfunction

Indirect Impact on Male Fertility o Therapeutic impact (e.g. Diuretics, Beta Blockers, Statins, o Surgical implications

Recommendations o Which therapy is safe o Life style changes

In the Female

Types o Ischemic heart disease o Stroke o Hypertension o Hypercholesterolemia o Dyslipidemia

Direct Impact on Female Fertility o Impact on menstrual cycle o Endometrial cycle o Ovarian Cycle o Libido

Indirect Impact on Male Fertility o Therapeutic impact (e.g. Diuretics, Beta Blockers, Statins) o Surgical implications


Chapter 3: Cancers In the Male

Types o Haematological Cancers (e.g Lymphoma, Leukemia) o Solid Cancers (Prostate, Testicular)

Direct Impact on Male Fertility o Impact on spermatogenesis o Impact on sperm functions o Erectile dysfunction

Indirect Impact on Male Fertility o Radiation therapy o Chemotherapy o Surgical implications

Recommendations o Fertility preservation o Life style



In the Female

Types o Haematological Cancers (e.g Lymphoma, Leukemia) o Solid Cancers (Ovarian, cervical, Uterine, Breast)

Direct Impact on Male Fertility o Impact on menstrual cycle o Impact on fertilization o Pregnancy and Lactation

Indirect Impact on Male Fertility o Radiation therapy o Chemotherapy o Surgical implications

Recommendations o Fertility preservation o Life style changes

Chapter 4: Endocrine and Metabolic Disorders 4.1 Diabetes In the Male

Types o DM type I o DM type II


Indirect Impact on Male Fertility o Therapeutic impact


In the Female

Types o DM type I o DM type II

Direct Impact on female Fertility o Impact on menstrual cycle

Indirect Impact on Female Fertility o Therapeutic impact




4.2 Obesity In the Male

Direct Impact on Male Fertility o Impact on spermatogenesis o Impact on sperm functions o Erectile dysfunction o Libido

Indirect Impact on Male Fertility o Physical impact (e.g. scrotal temperature) o Therapeutic impact o Bariatric surgery impact

Recommendations o Which therapy is safe o Surgery? o Life style changes

In the Female

Direct Impact on Female Fertility o Impact on Menstrual cycle o Impact on fertilization o Impact on hormones

Indirect Impact on Female Fertility o Physical impact (adiposity) o PCOS o Therapeutic impact o Bariatric surgery impact

Recommendations o Which therapy is safe o Surgery? o Life style changes

4.3 PITUITARY, THYROID AND ADRENAL DISORDERS In the Male

Direct Impact on Male Fertility o Impact on spermatogenesis o Impact on sperm functions o Erectile dysfunction o Libido

Indirect Impact on Male Fertility o Physical impact o Therapeutic impact o Surgical impact

Recommendations o Which therapy is safe



In the Female

Direct Impact on Female Fertility o Impact on Menstrual cycle o Impact on fertilization

Indirect Impact on Female Fertility o Physical impact o Therapeutic impact o Surgical impact

Recommendations o Which therapy is safe o Surgery

Chapter 5: Mental Health In the Male

Types o Schizophrenia/Bipolar o Stress/Anxiety o Eating disorders (Anorexia/Bulimia)


Indirect Impact on Male Fertility o Therapeutic impact (antidepressants/antipsychotics)

Recommendations o Which therapy is safe o Counseling o Life style changes

In the Female

Types o Schizophrenia/Bipolar o Stress/Anxiety o Eating disorders (Anorexia/Bulimia)

Direct Impact on Male Fertility o Impact on menstrual cycle o Endometrial cycle o Ovarian Cycle o Libido


Recommendations o Which therapy is safe o Counseling o Life style changes



Chapter 6: Gastrointestinal Diseases In the Male

Types o Irritable Bowel Syndrome o Crohn’s Disease o Ulcerative Colitis

Direct Impact on Male Fertility o Impact on spermatogenesis o Impact on sperm functions

Indirect Impact on Male Fertility o Therapeutic impact

Recommendations o Which therapy is safe o Surgical implications o Life style changes

In the Female

Types o Irritable Bowel Syndrome o Crohn’s Disease o Ulcerative Colitis

Direct Impact on Male Fertility o Impact on menstrual cycle o Endometrial cycle o Ovarian Cycle


Recommendations o Which therapy is safe o Surgical implications o Life style changes

Chapter 7: Future Perspectives and Conclusion Literature review:

A preliminary literature search has been done using resources of the Cleveland Clinic Alumni Library. An

exhaustive literature review needs to be conducted before the manuscript is written.



Suggested reading:

1. Davis R, Reveles KR, Ali SK, Mortensen EM, Frei CR, Mansi I. Statins and male sexual health: a retrospective cohort analysis. J Sex Med. 2015 Jan;12(1):158-67. doi: 10.1111/jsm.12745. Epub 2014 Nov 25.

2. Morrison CD, Brannigan RE. Metabolic syndrome and infertility in men. Best Pract Res Clin Obstet Gynaecol. 2014 Oct 24. pii: S1521-6934(14)00217-X. doi: 10.1016/j.bpobgyn.2014.10.006. [Epub ahead of print]

3. Eisenberg ML, Li S, Behr B, Pera RR, Cullen MR. Relationship between semen production and medical comorbidity. Fertil Steril. 2015 Jan;103(1):66-71. doi: 10.1016/j.fertnstert.2014.10.017. Epub 2014 Dec 10.

4. Salonia, R. Matloob, A. Gallina, F. Abdollah, A. Sacca, A. Briganti, et al. Are infertile men less healthy than fertile men? Results of a prospective case-control survey Eur Urol, 56 (2009), pp. 1025–1031

5. M.G. Hull, C.M. Glazener, N.J. Kelly, D.I. Conway, P.A. Foster, R.A. Hinton, et al.

6. Population study of causes, treatment, and outcome of infertility. BMJ, 291 (1985), pp. 1693–1697

7. A.J. Gaskins, D.S. Colaci, J. Mendiola, S.H. Swan, J.E. Chavarro Dietary patterns and semen quality in young men. Hum Reprod, 27 (2012), pp. 2899–2907

8. M.A. Ramirez-Torres, A. Carrera, M. Zambrana. High incidence of hyperestrogenemia and dyslipidemia in a group of infertile men. [in Spanish] Ginecol Obstet Mex, 68 (2000), pp. 224–229

9. M.L. Eisenberg, S. Li, B. Behr, M.R. Cullen, D. Galusha, D.J. Lamb, et al. Semen quality, infertility and mortality in the USA. Hum Reprod, 29 (2014), pp. 1567–1574

10. M.L. Eisenberg, P. Betts, D. Herder, D.J. Lamb, L.I. Lipshultz. Increased risk of cancer among azoospermic men. Fertil Steril, 100 (2013), pp. 681–685.e1

11. R. Jacobsen, E. Bostofte, G. Engholm, J. Hansen, J.H. Olsen, N.E. Skakkebaek, et al. Risk of testicular cancer in men with abnormal semen characteristics: cohort study. BMJ, 321 (2000), p. 789

12. T.J. Walsh, M. Schembri, P.J. Turek, J.M. Chan, P.R. Carroll, J.F. Smith, et al. Increased risk of high-grade prostate cancer among infertile men. Cancer, 116 (2010), pp. 2140–2147

13. N.E. Skakkebaek, E. Rajpert-De Meyts, K.M. Main. Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects. Hum Reprod, 16 (2001), pp. 972–978

14. N. Sermondade, C. Faure, L. Fezeu, A.G. Shayeb, J.P. Bonde, T.K. Jensen, et al. BMI in relation to sperm count: an updated systematic review and collaborative meta-analysis. Hum Reprod Update, 19 (2013), pp. 221–231

15. D. Dinulovic, G. Radonjic. Diabetes mellitus/male infertility. Arch Androl, 25 (1990), pp. 277–293

16. G. Gaunay, H.M. Nagler, D.S. Stember. Reproductive sequelae of diabetes in male patients. Endocrinol Metab Clin North Am, 42 (2013), pp. 899–914

17. B. Muciaccia, S. Pensini, F. Culasso, F. Padula, D. Paoli, L. Gandini, et al. Higher clusterin immunolabeling and sperm DNA damage levels in hypertensive men compared with controls. Hum Reprod, 27 (2012), pp. 2267–2276

http://www.ncbi.nlm.nih.gov/pubmed/?term=Davis%20R%5BAuthor%5D&cauthor=true&cauthor_uid=25421152

http://www.ncbi.nlm.nih.gov/pubmed/?term=Reveles%20KR%5BAuthor%5D&cauthor=true&cauthor_uid=25421152

http://www.ncbi.nlm.nih.gov/pubmed/?term=Ali%20SK%5BAuthor%5D&cauthor=true&cauthor_uid=25421152

http://www.ncbi.nlm.nih.gov/pubmed/?term=Mortensen%20EM%5BAuthor%5D&cauthor=true&cauthor_uid=25421152

http://www.ncbi.nlm.nih.gov/pubmed/?term=Frei%20CR%5BAuthor%5D&cauthor=true&cauthor_uid=25421152

http://www.ncbi.nlm.nih.gov/pubmed/?term=Mansi%20I%5BAuthor%5D&cauthor=true&cauthor_uid=25421152


http://www.ncbi.nlm.nih.gov/pubmed/?term=Morrison%20CD%5BAuthor%5D&cauthor=true&cauthor_uid=25487258

http://www.ncbi.nlm.nih.gov/pubmed/?term=Brannigan%20RE%5BAuthor%5D&cauthor=true&cauthor_uid=25487258



http://www.ncbi.nlm.nih.gov/pubmed/?term=Eisenberg%20ML%5BAuthor%5D&cauthor=true&cauthor_uid=25497466

http://www.ncbi.nlm.nih.gov/pubmed/?term=Li%20S%5BAuthor%5D&cauthor=true&cauthor_uid=25497466

http://www.ncbi.nlm.nih.gov/pubmed/?term=Behr%20B%5BAuthor%5D&cauthor=true&cauthor_uid=25497466

http://www.ncbi.nlm.nih.gov/pubmed/?term=Pera%20RR%5BAuthor%5D&cauthor=true&cauthor_uid=25497466

http://www.ncbi.nlm.nih.gov/pubmed/?term=Cullen%20MR%5BAuthor%5D&cauthor=true&cauthor_uid=25497466




18. R.D. Motrich, M. Maccioni, R. Molina, A. Tissera, J. Olmedo, C.M. Riera, et al. Reduced semen quality in chronic prostatitis patients that have cellular autoimmune response to prostate antigens. Hum Reprod, 20 (2005), pp. 2567–2572

19. Sussman, J.M. Leonard. Psoriasis, methotrexate, and oligospermia. Arch Dermatol, 116 (1980), pp. 215–217

Intended audience:

This authoritative review will be of particular interest to reproductive biologists and clinicians dealing

with the complications of infertility in their research and medical practice.

Book Chapters:

In: Non-communicable diseases and their impact on Fertility, SpringerBriefs in Reproductive Medicine,

Springer.

Deadline:

July 31, 2015

Last Updated: July 1, 2015

Assignment of Scientific Writing Projects

Note: The Lead Mentor is highlighted.

Springer Brief Book 1: OXIDATIVE STRESS IN HUMAN REPRODUCTION – SHEDDING

LIGHT ON A COMPLICATED PHENOMENON

Chapter Title Intern Mentors

Chapter 1

1A: Overview & Sources of Reactive Oxygen

Species in the Reproductive System- Redox

reactions, ROS, RNS, AOX, OS

Mazen AlMasry

GULFAM AHMAD, PhD

Dama D., PhD

1B: Overview & Sources of Reactive Oxygen

Species in the Reproductive System- Sources of

ROS in the Male Reproductive system

Amolak Dhillon

1C: Overview & Sources of Reactive Oxygen

Species in the Reproductive System- Sources of

ROS in the Female Reproductive system

Muna Abuayyash

Chapter 2

2A: Methods to Measure Reactive Oxygen

Species (and TAC) in the Reproductive System-

Microscopy, Chemiluminescence,

Epifluorescence, Flow cytometry

Nirvika Singh

RAKESH SHARMA, PhD

Ahmet Ayaz, PhD 2B: Methods to Measure Reactive Oxygen

Species (and TAC) in the Reproductive System-

TAC, ELISA, Immunohistochemistry, Western

Blotting

Yash Sarda

Chapter 3

3A: Physiological Role of Reactive Oxygen

Species in the Male Reproductive System

Mohamed

Abdelaziz STEFAN DU PLESSIS, PhD

3B: Physiological Role of Reactive Oxygen

Species in the Female Reproductive System

Eiad Habib Avi Harlev, MD

Chapter 4

4A: Negative Effects of the Oxidative Stress in

the Male Reproductive System

Rakan Alsaad

RAKESH SHARMA, PhD

Ahmet Ayaz, PhD

4B: Negative Effects of the Oxidative Stress in

the Female Reproductive System

Fares

Bamajbuor

Chapter 5

5A: Factors Inducing Oxidative Stress in the

Male Reproductive System

Luay Al Kattan Stefan du Plessis, PhD

5B: Factors Inducing Oxidative Stress in the

Female Reproductive System

Deepak Kumar Avi Harlev, MD


Chapter 6

6A: Pathological Role of Reactive Oxygen

Species in Complications/Diseases Related to the

Male Reproductive System

My Tran GULFAM AHMAD, PhD

Sajal Gupta, MD

Rakesh Sharma, PhD

6B: Pathological Role of Reactive Oxygen


Female Reproductive System-Pregnancy,

Menopause, PCOS

Ghada AlHayaza Gulfam Ahmad, PhD

SAJAL GUPTA, MD

6C: Pathological Role of Reactive Oxygen


Female Reproductive System-Endometriosis,

Unexplained infertility, Gestational DM

Zeina Kayali Gulfam Ahmad, PhD

SAJAL GUPTA, MD

Chapter 7

7A: Therapeutic Role of Antioxidants (AOX) in

the Treatment of Infertility in the Male

Saad

AlQasem


7B: Therapeutic Role of Antioxidants (AOX) in

the Treatment of Infertility in the Female

Mohammad

Nouh

Sajal Gupta, MD


Springer Brief Book 2: NON-COMMUNICABLE DISEASES AND THEIR IMPACT ON

FERTILITY

Chapter Title Intern Mentors

Introduction

Introduction to the Brief Abdullah Al-

Harbi


Gulfam Ahmad, PhD

Chapter 1

1A: Cardiovascular Disease in the Male Ahmed ElShaer Sajal Gupta, MD

1B: Cardiovascular Disease in the Female Wassel Sannaa Avi Harlev, MD

Chapter 2

2A: Cancers in the Male Chris Douglas GULFAM AHMAD, PhD

Rakesh Sharma, PhD

2B: Cancers in the Female Carolina Martines Sajal Gupta, MD

Chapter 3

3A: Diabetes in the Male Anas Abdelqader Stefan du Plessis, PhD

3B: Diabetes in the Female Ibrahim Al-

Tamimi

Gulfam Ahmad, PhD

Chapter 4

4A: Obesity in the Male Carolina Speyer Stefan du Plessis, PhD

4B: Obesity in the Female Alvaro Ramos Gulfam Ahmad, PhD

Chapter 5

5A: Pituitary, Thyroid, and Adrenal Disorders in

the Male

Ali AlGonaim

Gulfam Ahmad, PhD

5B: Pituitary, Thyroid, and Adrenal Disorders in

the Female

Saad AlJuhaim

Chapter 6

6A: Mental Health in the Male Talal Hijji AVI HARLEV, MD


6B: Mental Health in the Female Cassidy Smith AVI HARLEV, MD

Gulfam Ahmad, PhD

Chapter 7

7A: Gastrointestinal Diseases in the Male Reva Peer Sajal Gupta, MD

7B: Gastrointestinal Diseases in the Male Abdullah Alzaaqi Avi Harlev, MD

Documents

SCIENTIFIC WRITING - clevelandclinic.org · Synopsis of Writing Project 2 73. SI 2015 Scientific Writing Projects. doc Ashok Agarwal, PhD Professor, Lerner College of Medicine Director,