Scientific WritingScientific Writing

Mehmet Tevfik DORAK, MD PhDMehmet Tevfik DORAK, MD PhD

Robert Stempel College of Public Health and Social Robert Stempel College of Public Health and Social WorkWork

Department of Environmental & Occupational HealthDepartment of Environmental & Occupational Health

February 5, 2013February 5, 2013

1

2

3

(www)4

5

6

7

Scientific WritingScientific Writing

Scientific WritingScientific WritingMain source:

8

Basic principles of scientific writing

Advice on sections of a scientific article

Additional advice on good practice

Uniform requirements for manuscripts submitted to biomedical journals

Appendix: Additional sources

Scientific WritingScientific WritingOutline

9

Scientific Writing: BasicsScientific Writing: Basics

10

Scientific Writing: BasicsScientific Writing: Basics

11

DO NOT:

- Make long, complicated sentences; just say it

- Use longer words when there is a simpler alternative (utilize vs. use; perform vs. do)

- Use jargon; just say it in plain English

- Try to overwhelm the reader with your knowledge; making sense and putting across your ideas in a conmprehensible way is more

important

Scientific Writing: BasicsScientific Writing: Basics

12

Title and AbstractTitle and Abstract

13

TITLETITLE- Are the title and research question closely related?

- Is the title objective in tone?- Are special features of the study mentioned?

ABSTRACTABSTRACT- Are there introduction, methods, results and

conclusions sections even if they are not explicitly labelled as such?

- Are the main features of the study mentioned?- Are the key results of the study stated in words?

- Do the conclusions flow from the results?- Did you follow all the rules of the journal?

14

15

Characteristics of a Good Characteristics of a Good AbstractAbstract

16

Stands on its own without need to read the paper States the hypothesis, question, or objective of the study

Completes the story by answering the hypothesis, question, or objective Contains the same key words and terms as the title and the introduction

Follows the correct style and format Follows the order of the main text

Stays within the allowed word count Does not contain information absent in the paper

Does not make conclusions unsupported by the data Limits the use of abbreviations

Does not include references Does not cite tables or figures

Conference AbstractConference Abstract

17

What to avoid:Lack of originality

No background, no implicationsSmall study, lack of statistical power, inconclusive

resultsNo numbers, too much talk

All numbers, no wordsToo short, too different

Sloppiness as a proxy for lack of care and qualityToo many abbreviations

Inappropriate statements (present your data and discuss your results rather than promising to do so)

Abstract Writing ExerciseAbstract Writing Exercise

18

IL-6 and β-selectin as prognostic markers for atherosclerotic disease

Background: Atherosclerotic disease is a major cause of death in the United States. We investigated which analyte, IL-6 or β-selectin, would be a better prognostic marker for

atherosclerotic disease. Methods: We divided patients into 4 groups. Specimens from each patient were tested for

interleukin-6 and β-selectin and matched against the patient’s disease group. During the study period, these analytes were measured again to determine whether concentrations changed with

disease severity. Mortality was also monitored for each group to investigate any relationship between IL-6 or β-selectin and the risk of death.

Results: The IL-6 concentrations were different between groups, with the IL-6 concentrations significantly different between groups 1 and 3, and 1 and 4. Although IL-6 and β-selectin

concentrations both changed, β-selectin changed by only 10% to 30%. Changes in disease severity were reflected in changes in IL-6. IL-6 values were the same for men and women and did not show any relationship with patient age. Intraindividual variation for IL-6 was much lower than that for β-

selectin. Conclusions: IL-6 and β-selectin concentrations change with a change in heart disease severity. Intraindividual variation of IL-6 was also much lower than β-selectin, further validating the use of

IL-6 over β-selectin. Further work is needed to confirm this observation.

Abstract Writing ExerciseAbstract Writing Exercise

19

Interleukin-6 as a prognostic marker for atherosclerotic disease

Background: Serum concentrations of the vascular inflammation marker β-selectin correlate with atherosclerotic disease severity, but β-selectin has a large intraindividual variation. We

investigated whether interleukin-6 (IL-6), another marker of vascular inflammation, could predict disease severity and mortality risk.

Methods: Consecutive outpatients undergoing evaluation for peripheral vascular disease (PVD) were divided into categories ranging from no functional impairment (group 1) to severe functional impairment (group 4). Blood was collected at baseline and quarterly over 3 years. Serum IL-6 and β-selectin were quantified to calculate intraindividual variation and to assess the relationships of

these markers to disease severity and mortality. Results: Baseline median IL-6 concentrations were 12, 26, 96, and 144 μg/L for categories 1 to 4,

respectively (P < 0.001 for categories 3 and 4 vs 1) and were not found related to age or sex. Median β-selectin concentrations increased 30% across the 4 categories. Increased disease

severity and mortality were associated with higher IL-6 concentrations (P < 0.01 for both), but not β-selectin. Intraindividual variation for group 1 was 14% for IL-6 and 36% for β-selectin.

Conclusions: IL-6 appears to be a better marker of disease severity and mortality than β-selectin in patients with PVD, with lower intraindividual variation and significant concentration changes with

increasing disease severity.

IntroductionIntroduction

20

- Are the four major elements (background, existing research, problems with that research or gaps in

knowledge, your improvements) covered in four or fewer paragraphs?

- Is it possible for a reader to tell why you did the study and why it is an improvement over existing knowledge?- Do you use an objective tone when criticizing previous

work?- Do you describe how your study addresses the

problems of previous research?- Is there anything extraneous in your introduction?

Material/Subjects & Material/Subjects & MethodsMethods

21

- Could a reader reproduce your study based on the details you provide?

- Did you mention the design of the study?- Are the setting, source and number of subjects, and

inclusion/exclusion criteria for subjects clear?- Are the measurements described in a logical order?

Are quality issues addressed?- Did you state how you measured the effect size, and

how you determined whether it was statistically significant?

ResultsResults

22

- Did you provide the basic results of the study (including descriptive characteristics)? Did you

continue with main results, other important findings and additional results?

- Are the effect sizes for the main outcomes of the study easy to find?

- Does the text complement the tables and figures? - Are unusual or surprising results in their proper

place?

*** THE MOST IMPORTANT SECTION ***

Figures & TablesFigures & Tables

23

TABLES- Is the title sufficiently descriptive without being Tolstoyesque?

- If the table tidy? (Rows and columns line up, each column centred under its heading, headings italicised, etc.)

- Are there any unneeded data, repeated Ns, excessive precision or ambitious abbreviations?

- Is the meaning of every item obvious without referring to the text?- Can any two of them be combined?

- Are all the tables cited in the text and in the right order?

FIGURES- Does every figure make its point clearly?

- Are the axes, lines bars and points labelled? Are the scales correct and comparable?

- Does each figure have a legend, not a title?- Are the figures numbered and are they cited in the right order?

- Does the text and figures complement each other or create redundancy?

DiscussionDiscussion

24

- Did you discuss the key findings and explain why they matter?- Have you indicated the strength of your convictions?

- Did you mention alternative interpretations of your results?- Have you included the limitations and strengths of the study?

- Did you make recommendations about what should happen next?- Did you present any new data in the discussion? If so, move them

to the results section.- Does each paragraph flow from the previous one and do you make

your point in the beginning of each paragraph?- Are there trivial points that can be eliminated?

25

ReferencesReferences

26

- Did you provide a reference for all non-obvious statements of fact?

- Did you follow the instructions of the publisher for unpublished data, abstracts or personal

communications?- Did you cite only the references that you have read

and understood?- Did you prepare the reference list in the special

format for the target journal? - Did you update thereference list before submission?

- If no special format is indicated, have you been consistent?

Other BitsOther Bits

27

Running title Keywords (MESH)

Author contributionsConflict of interest statements

AcknowledgementsReviewer suggestions and exclusions

Cover letter

When the manuscript is finished, look back to see:- Does the title make sense or the text has changed drastically

and you need a new title?- Have you made your research question clear?

- Have you provided an answer? - Have you made it clear: (a) how your work adds to the previous knowledge, and what gap it fills, and (b) what progress does your

work represent?

In other words:Do not bother with a statistical exercise based on a convenience sample. In the Discussion, all you have to say should not be just how many other studies are out there and how inconsistent the results are, and your study is just another inconclusive addition

to the mix.

28

Looking BackLooking Back

Even if not required:- Prepare key messages

- Try to summarize your work for lay people

Read the review criteria of the journal

Do not ask anyone to review your paper without providing a title and an abstract!

29

Good PracticeGood Practice

30

- Importance of research subject studied- Originality

- Appropriateness and adequcy of study design- Strength of evidence supporting conclusions

- Quality and length of presentation- Duplication of data in text, tables and figures

- Appropriate and adequate citing of previous work

Typical Review CriteriaTypical Review Criteria

31

Uniform RequirementsUniform Requirements

Scientific WritingScientific Writing

Mehmet Tevfik DORAKMehmet Tevfik DORAKRobert Stempel College of Public Health and Social WorkRobert Stempel College of Public Health and Social Work

Department of Environmental & Occupational HealthDepartment of Environmental & Occupational HealthFebruary 5, 2013February 5, 2013

Thank you for Your Thank you for Your Attention!Attention!

33

Scientific WritingScientific Writing

Appendix: Appendix: Additional ResourcesAdditional Resources

http://www.dorak.info/fiu/sci_write.html

http://www.nature.com/scitable/ebooks/english-communication-for-scientists-14053993/writing-scientific-papers-14239285

http://www.americanscientist.org/issues/pub/the-science-of-scientific-writing

https://cgi.duke.edu/web/sciwriting/index.php

http://abacus.bates.edu/~ganderso/biology/resources/writing/HTWtoc.html

http://www.scidev.net/en/practical-guides/how-do-i-write-a-scientific-paper-.html

http://classweb.gmu.edu/biologyresources/writingguide/index.htm

http://www.fhsu.edu/biology/Eberle/BIOL825Lecture2

http://www.amazon.com/Scientific-English-Guide-Scientists-Professionals/dp/0313391947/ref=pd_sim_sbs_b_4

http://www.amazon.com/How-Write-Publish-Scientific-Paper/dp/0313391955/ref=dp_ob_title_bk