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Rheumatoid arthritis and seronegative spondylarthritides Nov 24, 2017 György Nagy

Rheumatoid arthritis and seronegative spondylarthritides

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Page 1: Rheumatoid arthritis and seronegative spondylarthritides

Rheumatoid arthritis and seronegative

spondylarthritides

Nov 24, 2017

György Nagy

Page 2: Rheumatoid arthritis and seronegative spondylarthritides

Rheumatoid arthritis

Page 3: Rheumatoid arthritis and seronegative spondylarthritides

Rheumatoid arthritis

Chronic, progressive, autoimmune disorder of the joints with extra-articular features.

Prevalence: 1% (0.3-2.1%)

Female/male = 3:1

Age at onset 30-40 years

Page 4: Rheumatoid arthritis and seronegative spondylarthritides

Early RA

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Advanced RA

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End stage RA

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Extra-articular features

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Extra-articular features

Page 10: Rheumatoid arthritis and seronegative spondylarthritides

Iain B. McInnes, F.R.C.P., Ph.D., and Georg Schett, M.D. N Engl J Med 2011;

The pathogenesis of rheumatoid arthritis

Page 11: Rheumatoid arthritis and seronegative spondylarthritides

The pathogenesis of rheumatoid arthritis

Iain B. McInnes, F.R.C.P., Ph.D., and Georg Schett, M.D. N Engl J Med 2011;

Page 12: Rheumatoid arthritis and seronegative spondylarthritides

Autoantibodies in RA

Rheumatoid factor

- against the Fc portion of IgG

- occurs in 70% of the RA patients

- not specific for RA

Autoantibodies targeting citrullinated proteins

- highly specific for RA

- occurs in 70% of the RA patients

Page 13: Rheumatoid arthritis and seronegative spondylarthritides

Baka Z, Buzás E, Nagy G - Arthritis Res. Ther. (2009)

The pathogenesis of rheumatoid arthritis

Page 14: Rheumatoid arthritis and seronegative spondylarthritides

DAS 28 = disease activity score

Swollen and tender joints, patient’s global opininion, CRP or We

Page 16: Rheumatoid arthritis and seronegative spondylarthritides

Ronald F. van Vollenhoven

Nature Reviews Rheumatology 7, 205-215 (April

2011)

Biological therapy in RA & side effects

Page 17: Rheumatoid arthritis and seronegative spondylarthritides

Ankylosing spondylitis

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Ankylosing spondylitis

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Thank you for your attention