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Resurse naturale terapeutice din Romania
Constantin MunteanuRomanian Association of Balneology
Viata intrauterina / impactul balnear Rolul psiho-emotional al balneoterapiei
EvolutionismISTORIA
BALNEOLOGIEI
PresenterPresentation NotesSpectroscopy:spectroscopy analysis of some sort preferred with the best resolution PCA: principle component analysis on the digitized spectrum (This itself can be sufficient to dived sample set into number of categories|)DFA :when PCA is not enough it is important to investigate the variable that can be important in discriminating between samples GA: Back to NMR signals if it is possible identify the signals that leads back to the metabolites that they represent.BALNEOTERAPIA Balneoterapia: metoda terapeutica de stimulare - adaptare
a organismului, aplicata sub forma bailor, inhalatiilor si ingestiei de factori naturali terapeutici.
Factori Naturali terapeutici: Ape minerale terapeutice carbogazoase, sarate si sulfuroase; Lacuri terapeutice: Lacul Ursu Sovata, Lacul Techirghiol Peloizi namoluri terapeutice; Gaze / MOFETE (CO2, radon and H2S), Factori de bioclimat CLIMATOTERAPIEMicroclimat - SPELEOTERAPIE
Importana cercetrii resurselor naturale este esenial n promovarea de ctre o staiune balnear a argumentelor care stau la baza proprietilor terapeutice ale factorilor naturali, contribuia lor la sntate, identificarea mecanismelor biologice prin care acetia acioneaz n organism.
Natural resources for healthy ageing
PresenterPresentation NotesSpectroscopy:spectroscopy analysis of some sort preferred with the best resolution PCA: principle component analysis on the digitized spectrum (This itself can be sufficient to dived sample set into number of categories|)DFA :when PCA is not enough it is important to investigate the variable that can be important in discriminating between samples GA: Back to NMR signals if it is possible identify the signals that leads back to the metabolites that they represent.Healthy Ageing Research on healthy ageing interventions has
evolved along the main theories of ageing. Pharmacological intervention to decelerate ageing
and age-related diseases is highly attractive because it would target all the population during many years.
If successful, healthy ageing therapy will be more efficient in reducing mortality than to fight separately each age-related disease.
The potential for further advances in this field is immense; hundreds of genes in several pathways have recently emerged as regulators of ageing and caloric restriction.
Some of these genes, such as IGF1R and FOXO3, have also been associated with human longevity in genetic association studies.
Conceptul de STATIUNE BALNEARA
Preventie Wellness - SPA Educatie pentru sanatate Recreatie / Relaxare
Tratament Curativ Complementar Paleativ
Recuperare medicala
Mental
Societal
Medical
Physical
Spiritual
Environmental Natural
Recreational Cultural
BALNEOLOGIE si Recuperare medicala in bolile cardiovasculare
Recuperarea cardiaca este reprezentata de programe complexe pe termen lung care includ evaluarea medicala, prescrierea activitatii fizice si modificarea factorilor de risc (OMS).
Aceste programe au ca scop limitarea efectelor fiziologice si psihologice ale bolii cardiace, reducerea riscului de moarte subita, controlarea simptomelor cardiace, stabilizarea sau regresia aterosclerozei si ameliorarea statusului psihosocial al pacientilor
Tratamentul balnear in afectiuni cardiovasculare
Statiuni recomandate:
Covasna, Baile Tusnad, Vatra Dornei, Buzias Calimanesti-Caciulata; Baile Herculane, Pucioasa Eforie Nord; Techirghiol; Mangalia (doar pentru
HTA de granita si HTA usoara, dar trebuie evitate in lunile iulie-august)
Moneasa; Geoagiu Bai
Covasna
Baile Tusnad
Techirghiol
BALNEOLOGIE si Recuperare medicala in afectiuni reumatismale
Cura n scop profilactic vizeaza sindroame dureroase musculo-articulare persistente
Cura n scop terapeutic vizeaza poliartrita reumatoid n stadii incipiente, cu fenomene inflamatorii prezente, spondilit ankilozant, artropatie psoriazic i artritele secundare unor infecii
Cura de recuperare se adreseaz bolnavilor cu poliartrit reumatoid n stadiile II sau III stabilizate biologic, dar cu deficite funcionale, forme de poliartrit reumatoid ce au suferit intervenii ortopedico-chirurgicale i forme constituite de spondilit ankilozant;
Obiectivele curei sunt diminuarea durerii, combaterea atrofiilor musculare, creterea mobilitii articulare, creterea capacitii de aprare a organismului, reechilibrarea terenului neuro-vegetativ.
Staiunile balneo-climatice din ara noastr sunt bine organizate i numeroase uniti medicale care pot rezolva aceast categorie de pacieni, n special Techirghiol, Sovata, Eforie Nord, Mangalia, Amara, Bile Felix .
Techirghiol
Sovata
Baile Felix
felixspa.com
felixspa.com
Cercetarea factorilor terapeutici naturali
PresenterPresentation NotesSpectroscopy:spectroscopy analysis of some sort preferred with the best resolution PCA: principle component analysis on the digitized spectrum (This itself can be sufficient to dived sample set into number of categories|)DFA :when PCA is not enough it is important to investigate the variable that can be important in discriminating between samples GA: Back to NMR signals if it is possible identify the signals that leads back to the metabolites that they represent.In contextul complex al functionarii organismului si al procesului patologic, descris ca un puzzle cu numeroase variabile independente, dificil de analizat, apare ca o necesitate identificarea unor biomarkeri relevanti a caror evolutie ne permite sa aducem dovezi privind valoarea terapeutica a factorilor naturali utilizati in statiunile balneare.
Biomarkeri17
PresenterPresentation NotesIt is true that the balneological, hydrological, climatological treatment methods are leading for the (traditional) definition of the field.16Animal model study: effects of Mary Mineral Water from Malnas Bai, Romania
PresenterPresentation NotesSpectroscopy:spectroscopy analysis of some sort preferred with the best resolution PCA: principle component analysis on the digitized spectrum (This itself can be sufficient to dived sample set into number of categories|)DFA :when PCA is not enough it is important to investigate the variable that can be important in discriminating between samples GA: Back to NMR signals if it is possible identify the signals that leads back to the metabolites that they represent.16Loturi sobolanimasculi
Greutate (g)
inainte dupa
Martor
108 113
107 125
106 132
112 133
90 146
Maria
111 130
101 135
100 128
116 120
116 116
Mariasol
113 116
112 143
103 126
116 126
106 127
Bor
112 116
118 144
126 134
104 123
106 142
Greutate loturi sobolani Wistar masculi
Mean MeanSE Mean2*SD M
arto
r ina
inte
Mar
tor d
upa
Mar
ia in
aint
e
Mar
ia d
upa
Mar
iaso
l ina
inte
Mar
iaso
l dup
a
Bor
inai
nte
Bor
dup
a
0
50
100
150
Gre
utat
e (g
)
Loturi sobolani femele
Greutate (g)
inainte dupa
Martor
120 128
108 143
123 153
113 135
112 136
Maria
108 138
119 143
118 132
118 133
116 146
Mariasol
111 126
108 124
94 120
102 131
98 110
Bor
98 127
113 135
110 120
96 124
98 121
Greutate loturi sobolani Wistar femele
Mean MeanSE Mean2*SD M
arto
r ina
inte
Mar
tor d
upa
Mar
ia in
aint
e
Mar
ia d
upa
Mar
iaso
l ina
inte
Mar
iaso
l dup
a
Bor
inai
nte
Bor
dup
a
0
50
100
150
Can
titat
e ap
a (m
l)
PresenterPresentation NotesSpectroscopy:spectroscopy analysis of some sort preferred with the best resolution PCA: principle component analysis on the digitized spectrum (This itself can be sufficient to dived sample set into number of categories|)DFA :when PCA is not enough it is important to investigate the variable that can be important in discriminating between samples GA: Back to NMR signals if it is possible identify the signals that leads back to the metabolites that they represent.39,80 44,53
29,00
45,00
0
50
100
Martor Maria Mariasol Bor
Loturi sobolani Wistar-masculi
Valo
ri tri
glice
ride (
mg/
dl)
Martor
Maria
Mariasol
Bor
Chart11Martor10.21.4Maria11.22Mariasol21.10.6Bor0.93.6Loturi sobolani Wistar-masculiValori trigliceride (mg/dl)39.844.5254529Sheet1CreatininaMartor masculiMaria masculiMariasol masculiBor masculiMartor femeleMaria femeleMariasol femeleBor femele10.280.260.090.260.270.270.260.2120.220.270.20.310.220.230.230.2830.380.280.230.260.330.20.250.2840.320.250.240.270.30.19medie0.30.2650.17333333330.27666666670.2650.24250.260.24sdv0.06733003290.01290994450.0737111480.02886751350.04795831520.03403429640.02943920290.0469041576MartorMariaMariasolBorMartor masculMaria masculMariasol masculBor masculMartor femelaMaria femelaMariasol femelaBor femelaColesterol163.5958.7374.5259.150.2430.0656.9658.54260.5241.7743.9642.6242.7642.7343.8450.16352.2535.7343.3346.1849.8239.1735.0746.56444.4738.536.8643.2644.550.82medie55.207543.682553.936666666749.344.9238.80545.092551.52sdv8.612581397810.330948246217.82847254638.67170110196.37551566546.10630548429.00384871415.0405555249Martor masculMaria masculMariasol masculBor masculMartor femelaMaria femelaMariasol femelaBor femelaHDL Colesterol124.4319.8821.622.1716.2514.6121.5526.67224.120.8915.323.4118.9422.2219.8922.4321.4720.0722.4118.4614.0621.28418.4617.1220.5315.7222.18medie23.3319.82518.4522.7918.6818.95517.80523.1325sdv1.62210768241.01003300284.45477272150.87681240872.72757523573.27947658433.49973808542.4075904275Martor masculMaria masculMariasol masculBor masculMartor femelaMaria femelaMariasol femelaBor femelaLDL Colesterol16.8613.4525.9514.0811.896.610.7715.9611.789.5910.2312.5312.2511.3210.910.8512.219.1912.999.319.498.049.5810.529.82medie13.6210.067518.0913.30511.67759.437510.24513.405sdv2.81702561822.348763859311.11571860031.09601551081.47140239232.06424118420.6964912063.6133156519Martor masculMaria masculMariasol masculBor masculMartor femelaMaria femelaMariasol femelaBor femelaTrigliceride38.53869.128.343.740.462.569.549.340.329.829.763.293.562.941.145.561.436.173.348.944.288.825.938.455.859.743.165.7medie39.8044.52545295960.62553.17566.275sdv10.289800775511.294652126921.10758157630.989949493712.469429283923.296262218111.008897916419.594961087Martor masculMaria masculMariasol masculBor masculMartor femelaMaria femelaMariasol femelaBor femelaGlucoza59.7474.79118.8494.5491.06115.9469.1893.42122.4286.38110.67171.37378.46238.64255.5575.47166.62279.13291.71218.7537.6385.55231.8299.81327.69447.1115.6593.57311.34medie112.15191.9975173.74132.955283.83251.965125.9625178.0125sdv44.6151598861130.2525514465102.246652267954.3270139986160.2228860057199.053282397886.9858545493113.0520892848Martor masculMaria masculMariasol masculBor masculMartor femelaMaria femelaMariasol femelaBor femelaProteine7.076.857.256.987.067.047.047.156.977.136.96.996.997.026.86.986.996.996.967.046.89medie7.076.95757.196.987.066.9257.01257.005sdv0.07455423080.08485281370.10115993940.03201562120.1075484387Martor masculMaria masculMariasol masculBor masculMartor femelaMaria femelaMariasol femelaBor femelaCalciu ionic12.1811.7916.5610.5211.3812.49.7512.239.288.029.468.478.797.928.469.988.458.068.877.398.858.878.43medie9.979.6611.4910.529.1959.62258.353333333312.23sdv1.95451613791.63146151254.41969455961.49373134581.86152938911.2382379954Martor masculMaria masculMariasol masculBor masculMartor femelaMaria femelaMariasol femelaBor femelaMagneziu2.052.061.842.052.162.122.142.062.032.022.362.152.292.212.192.122.12.092.182.562.22.282.022.162.22.252.172.33medie2.052.08252.12.12.20752.2852.1752.1975sdv0.03559026080.05909032630.36769552620.07071067810.05737304830.19122412680.02645751310.1281600562Sheet10.040.040.030.030.080.080.040.04Loturi sobolani Wistar-femeleValori creatinina (mg/dl)Sheet28.68.610.310.317.817.88.68.6Loturi sobolani Wistar-masculiValori colesterol (mg/dl)Sheet36.36.36.16.19955Loturi sobolani Wistar-femeleValori colesterol (mg/dl)1.61.6114.44.40.80.8Loturi sobolani Wistar masculiValori HDL C (mg/dl)2.72.73.23.23.43.42.42.4Loturi sobolani Wistar femelevalori HDL C (mg/dl)2.82.82.32.311.111.111Loturi sobolani Wistar-masculiValori LDL C (mg/dl)1.41.4220.60.63.63.6Loturi sobolani Wistar-femeleValori LDL C (mg/dl)10.21.411.2221.10.60.93.6Loturi sobolani Wistar-masculiValori trigliceride (mg/dl)12.412.423.223.211111919Loturi sobolani Wistar-femeleValori trigliceride (mg/dl)44.644.6130130102102545416019986113000.070.070.080.0800000.10.10.030.030.10.11.91.91.61.64.44.4001.41.41.81.81.21.2000.030.030.050.050.30.30.070.070.050.050.190.190.020.020.120.120.060.060.010.010.070.070.020.02Loturi sobolani Wistar-masculiValori creatinina (mg/dl)CreatininaColesterolHDL ColesterolMartor masculMaria masculMariasol masculBor masculMartor femelaMaria femelaMariasol femelaBor femelaHCO3: 1903,2 mg/l,CO2: 2868,4 mg/lCa: 384,4 mg/lMg: 107, 1 mg/l,Total mineralization: 2554 mg/l.
1 2 3 4 5 6 7 8 9
S1
0
5
10
15
20
25
30
12
34
56
78
9S1
0
0,01
0,02
0,03
0,04
GLUCOZA SERICA ACID URIC
1 2 3 4 5 6 78 9
S1
0
10
20
30
40
1 2 3 4 5 6 7 8 9
S1
0
0.5
1
1.5
2
2.5
COLESTEROL TRIGLICERIDE
Experimental Design
IL6, CRP, MCSF, TNF-, MCP
Scientific arguments
Chart32.889531179926.272144838215.76702963699.13703099557.378040299520.520338488517.031693284118.399376295213.7127435745LDH47.3799.3952.02277.92230.550.483.671.447.3453.460.973063973197.3063973064237.890.969145403396.9145403338194.220937640297.11046882012.889531179928.9938.839.8448.2519.261.632.314.894.6214.730.668024439966.802443991923.880.806532663380.6532663317147.455710323573.727855161826.272144838238.1569.5731.4287.1649.011.854.855.559.736.970.849878279784.987827968658.710.834781127683.4781127576168.465940726284.232970363115.767029636936.8562.7525.992.0255.170.862.82.585.628.480.909410112490.94101123660.770.907849267790.7849267731181.72593800990.86296900459.137030995547.5957.329.73169.32121.730.441.761.323.5211.050.880542986488.0542986425125.250.971896207697.1896207585185.24391940192.62195970057.378040299548.1859.511.3274.2526.070.973.382.916.7614.230.795502459679.550245959232.830.794090770679.4090770637158.959323022979.479661511520.520338488547.978.9231.02246.17198.274.921.8414.763.6845.780.677588466667.7588466579201.950.981777667798.177766774165.936613431982.968306715917.031693284144.9967.4422.45352.36307.373.587.1410.7414.2833.190.676408556867.6408556794321.650.955603917395.5603917301163.201247409681.600623704818.399376295248.3476.7728.43218.58170.243.162.119.484.2237.910.749934054374.9934054339174.460.975811074297.5811074172172.574512851186.287256425513.7127435745LDHBIOCH1BIOCH2CREATININA0.1480.1980.050.1780.030.080.040.080.0890.0090.0990.0190.0280.0140.1180.1380.020.1280.010.030.0150.1280.1480.020.1380.010.030.0150.1580.2080.050.1780.020.070.0350.1580.1780.020.1880.030.050.0250.1580.1880.030.1880.030.060.030.1680.2080.040.1780.010.050.0250.1580.2080.050.1680.010.060.03FOSFATAZA ALCALINA74.52546.475-28.0528.0566.2758.2536.318.1547.8544.275-3.5753.57546.21.655.2252.612561.647.3-14.314.354.1757.42521.72510.862552.826.125-26.67526.67533.82518.97545.6522.82568.225.3-42.942.943.4524.7567.6533.82559.9520.07-39.8839.8835.47524.47564.35532.177577.5544.275-33.27533.27572.64.9538.22519.112578.6544.825-33.82533.82570.6757.97541.820.964.62530.525-34.134.146.218.42552.52526.2625UREE4.8688.1883.326.4731.6054.9252.46253.8724.260.3884.260.3880.7760.3884.096.031.945.1451.0552.9951.49754.595.971.385.20.611.990.9955.148.243.15.6430.5033.6031.80154.8686.3621.4945.530.6622.1561.0784.8687.1372.2696.1961.3283.5971.79855.097.6352.5456.030.943.4851.74254.8688.0223.1546.3621.4944.6482.324COLESTEROL3.4253.4253.2500.1750.1750.08752.2052.3222.0890.1170.1160.2330.11652.9022.672.7860.2320.1160.3480.1742.7862.9022.7280.1160.0580.1740.0873.3663.4833.4250.1170.0590.1760.0883.5413.4833.4230.0580.1180.1760.0883.3663.4833.250.1170.1160.2330.11653.3673.6573.3080.290.0590.3490.17453.4253.5413.1920.1160.2330.3490.1745TRIGLICERIDE7.6610.217.662.5502.551.27515.54.2865.19811.21410.30221.51610.7585.288.6637.0213.3831.7415.1242.5625.5596.935.9271.3710.3681.7390.86956.0189.6667.4773.6481.4595.1072.55359.6668.9377.1130.7292.5533.2821.6416.74811.8558.3895.1071.6416.7483.3745.01513.047.2048.0252.18910.2145.1078.66311.948.4813.2770.1823.4591.7295GPT0.52106.611.87106.0811.35117.4358.715-1.224.190.525.411.747.153.575-0.778.5710.4779.2711.1790.4445.22-12.213.447.15825.6419.35844.99822.499-1.0470.012.61971.053.65974.70937.3545-0.522.090.522.611.043.651.825-0.1747.9755.1748.1455.34103.4851.74-0.17138.4547.14138.6247.31185.9392.965-0.5279.6115.7180.1316.2396.3648.18MAGNEZIU13.5713.8813.870.310.30.610.30513.9814.2714.1320.290.1520.4420.22113.7614.0814.030.320.270.590.29513.8814.1714.030.290.150.440.2213.6413.9313.860.290.220.510.25513.6313.9413.950.310.320.630.31515.0515.5815.150.530.10.630.31514.414.8914.490.490.090.580.2914.3414.8714.440.530.10.630.315BIOCH2Chart40.040.0140.0150.0150.0350.0250.030.0250.03LDH47.3799.3952.02277.92230.550.483.671.447.3453.460.973063973197.3063973064237.890.969145403396.9145403338194.220937640297.11046882012.889531179928.9938.839.8448.2519.261.632.314.894.6214.730.668024439966.802443991923.880.806532663380.6532663317147.455710323573.727855161826.272144838238.1569.5731.4287.1649.011.854.855.559.736.970.849878279784.987827968658.710.834781127683.4781127576168.465940726284.232970363115.767029636936.8562.7525.992.0255.170.862.82.585.628.480.909410112490.94101123660.770.907849267790.7849267731181.72593800990.86296900459.137030995547.5957.329.73169.32121.730.441.761.323.5211.050.880542986488.0542986425125.250.971896207697.1896207585185.24391940192.62195970057.378040299548.1859.511.3274.2526.070.973.382.916.7614.230.795502459679.550245959232.830.794090770679.4090770637158.959323022979.479661511520.520338488547.978.9231.02246.17198.274.921.8414.763.6845.780.677588466667.7588466579201.950.981777667798.177766774165.936613431982.968306715917.031693284144.9967.4422.45352.36307.373.587.1410.7414.2833.190.676408556867.6408556794321.650.955603917395.5603917301163.201247409681.600623704818.399376295248.3476.7728.43218.58170.243.162.119.484.2237.910.749934054374.9934054339174.460.975811074297.5811074172172.574512851186.287256425513.7127435745LDHBIOCH1BIOCH2CREATININA0.1480.1980.050.1780.030.080.040.080.0890.0090.0990.0190.0280.0140.1180.1380.020.1280.010.030.0150.1280.1480.020.1380.010.030.0150.1580.2080.050.1780.020.070.0350.1580.1780.020.1880.030.050.0250.1580.1880.030.1880.030.060.030.1680.2080.040.1780.010.050.0250.1580.2080.050.1680.010.060.03FOSFATAZA ALCALINA74.52546.475-28.0528.0566.2758.2536.318.1547.8544.275-3.5753.57546.21.655.2252.612561.647.3-14.314.354.1757.42521.72510.862552.826.125-26.67526.67533.82518.97545.6522.82568.225.3-42.942.943.4524.7567.6533.82559.9520.07-39.8839.8835.47524.47564.35532.177577.5544.275-33.27533.27572.64.9538.22519.112578.6544.825-33.82533.82570.6757.97541.820.964.62530.525-34.134.146.218.42552.52526.2625UREE4.8688.1883.326.4731.6054.9252.46253.8724.260.3884.260.3880.7760.3884.096.031.945.1451.0552.9951.49754.595.971.385.20.611.990.9955.148.243.15.6430.5033.6031.80154.8686.3621.4945.530.6622.1561.0784.8687.1372.2696.1961.3283.5971.79855.097.6352.5456.030.943.4851.74254.8688.0223.1546.3621.4944.6482.324COLESTEROL3.4253.4253.2500.1750.1750.08752.2052.3222.0890.1170.1160.2330.11652.9022.672.7860.2320.1160.3480.1742.7862.9022.7280.1160.0580.1740.0873.3663.4833.4250.1170.0590.1760.0883.5413.4833.4230.0580.1180.1760.0883.3663.4833.250.1170.1160.2330.11653.3673.6573.3080.290.0590.3490.17453.4253.5413.1920.1160.2330.3490.1745TRIGLICERIDE7.6610.217.662.5502.551.27515.54.2865.19811.21410.30221.51610.7585.288.6637.0213.3831.7415.1242.5625.5596.935.9271.3710.3681.7390.86956.0189.6667.4773.6481.4595.1072.55359.6668.9377.1130.7292.5533.2821.6416.74811.8558.3895.1071.6416.7483.3745.01513.047.2048.0252.18910.2145.1078.66311.948.4813.2770.1823.4591.7295GPT0.52106.611.87106.0811.35117.4358.715-1.224.190.525.411.747.153.575-0.778.5710.4779.2711.1790.4445.22-12.213.447.15825.6419.35844.99822.499-1.0470.012.61971.053.65974.70937.3545-0.522.090.522.611.043.651.825-0.1747.9755.1748.1455.34103.4851.74-0.17138.4547.14138.6247.31185.9392.965-0.5279.6115.7180.1316.2396.3648.18MAGNEZIU13.5713.8813.870.310.30.610.30513.9814.2714.1320.290.1520.4420.22113.7614.0814.030.320.270.590.29513.8814.1714.030.290.150.440.2213.6413.9313.860.290.220.510.25513.6313.9413.950.310.320.630.31515.0515.5815.150.530.10.630.31514.414.8914.490.490.090.580.2914.3414.8714.440.530.10.630.315BIOCH2Chart518.152.612510.862522.82533.82532.177519.112520.926.2625LDH47.3799.3952.02277.92230.550.483.671.447.3453.460.973063973197.3063973064237.890.969145403396.9145403338194.220937640297.11046882012.889531179928.9938.839.8448.2519.261.632.314.894.6214.730.668024439966.802443991923.880.806532663380.6532663317147.455710323573.727855161826.272144838238.1569.5731.4287.1649.011.854.855.559.736.970.849878279784.987827968658.710.834781127683.4781127576168.465940726284.232970363115.767029636936.8562.7525.992.0255.170.862.82.585.628.480.909410112490.94101123660.770.907849267790.7849267731181.72593800990.86296900459.137030995547.5957.329.73169.32121.730.441.761.323.5211.050.880542986488.0542986425125.250.971896207697.1896207585185.24391940192.62195970057.378040299548.1859.511.3274.2526.070.973.382.916.7614.230.795502459679.550245959232.830.794090770679.4090770637158.959323022979.479661511520.520338488547.978.9231.02246.17198.274.921.8414.763.6845.780.677588466667.7588466579201.950.981777667798.177766774165.936613431982.968306715917.031693284144.9967.4422.45352.36307.373.587.1410.7414.2833.190.676408556867.6408556794321.650.955603917395.5603917301163.201247409681.600623704818.399376295248.3476.7728.43218.58170.243.162.119.484.2237.910.749934054374.9934054339174.460.975811074297.5811074172172.574512851186.287256425513.7127435745LDHBIOCH1BIOCH2CREATININA0.1480.1980.050.1780.030.080.040.080.0890.0090.0990.0190.0280.0140.1180.1380.020.1280.010.030.0150.1280.1480.020.1380.010.030.0150.1580.2080.050.1780.020.070.0350.1580.1780.020.1880.030.050.0250.1580.1880.030.1880.030.060.030.1680.2080.040.1780.010.050.0250.1580.2080.050.1680.010.060.03FOSFATAZA 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ALCALINA74.52546.475-28.0528.0566.2758.2536.318.1547.8544.275-3.5753.57546.21.655.2252.612561.647.3-14.314.354.1757.42521.72510.862552.826.125-26.67526.67533.82518.97545.6522.82568.225.3-42.942.943.4524.7567.6533.82559.9520.07-39.8839.8835.47524.47564.35532.177577.5544.275-33.27533.27572.64.9538.22519.112578.6544.825-33.82533.82570.6757.97541.820.964.62530.525-34.134.146.218.42552.52526.2625UREE4.8688.1883.326.4731.6054.9252.46253.8724.260.3884.260.3880.7760.3884.096.031.945.1451.0552.9951.49754.595.971.385.20.611.990.9955.148.243.15.6430.5033.6031.80154.8686.3621.4945.530.6622.1561.0784.8687.1372.2696.1961.3283.5971.79855.097.6352.5456.030.943.4851.74254.8688.0223.1546.3621.4944.6482.324COLESTEROL3.4253.4253.2500.1750.1750.08752.2052.3222.0890.1170.1160.2330.11652.9022.672.7860.2320.1160.3480.1742.7862.9022.7280.1160.0580.1740.0873.3663.4833.4250.1170.0590.1760.0883.5413.4833.4230.0580.1180.1760.0883.3663.4833.250.1170.1160.2330.11653.3673.6573.3080.290.0590.3490.17453.4253.5413.1920.1160.2330.3490.1745TRIGLICERIDE7.6610.217.662.5502.551.27515.54.2865.19811.21410.30221.51610.7585.288.6637.0213.3831.7415.1242.5625.5596.935.9271.3710.3681.7390.86956.0189.6667.4773.6481.4595.1072.55359.6668.9377.1130.7292.5533.2821.6416.74811.8558.3895.1071.6416.7483.3745.01513.047.2048.0252.18910.2145.1078.66311.948.4813.2770.1823.4591.7295GPT0.52106.611.87106.0811.35117.4358.715-1.224.190.525.411.747.153.575-0.778.5710.4779.2711.1790.4445.22-12.213.447.15825.6419.35844.99822.499-1.0470.012.61971.053.65974.70937.3545-0.522.090.522.611.043.651.825-0.1747.9755.1748.1455.34103.4851.74-0.17138.4547.14138.6247.31185.9392.965-0.5279.6115.7180.1316.2396.3648.18MAGNEZIU13.5713.8813.870.310.30.610.30513.9814.2714.1320.290.1520.4420.22113.7614.0814.030.320.270.590.29513.8814.1714.030.290.150.440.2213.6413.9313.860.290.220.510.25513.6313.9413.950.310.320.630.31515.0515.5815.150.530.10.630.31514.414.8914.490.490.090.580.2914.3414.8714.440.530.10.630.315BIOCH2Uric acid Cholesterol HDL LDL
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MCSF TNF-
PresenterPresentation NotesIt is true that the balneological, hydrological, climatological treatment methods are leading for the (traditional) definition of the field.Speleotherapy, the use of the climate of caves, is anaccepted but not widely known therapeutic measure inthe treatment of chronic obstructive airway diseases.This study summarizes the therapeutic experience ofmore than 4000 patients who were treated in a 10-yearperiod in a hospital-cave complex in Tapolca, Hungary.A sharp and long-lasting clinical improvement and asignificant recovery from airway obstruction could beobserved in the overwhelming majority of patients. It isestablished that the microclimate of some caves canbeneficially affect these disorders and the cave shouldbe considered as an optimal environment for complexrespiratory rehabilitation.
PresenterPresentation Notes28Objective: To explore the effects of speleotherapy oncellular morphology and physiology of pulmonary fibroblastsobtained from tissues of Wistar rats, in normal and Ovalbuminchallenged asthmatic conditions.
Materials and methods:Wistar rats of 75-100 g weight were divided in two lots:
control and ovalbumin challenged animals. Ten animals ofeach lot were send to Turda, Cacica and Dej Salt Mine for 14days and maintained in the salt mine medium, as inspeleotherapy treatment.
Pulmonary fibroblasts cultures were prepared from Wistarrat lung Assessing changes in cellular and molecular level canbe achieved by optical microscopy, immuno-histo-chemistrystudies, electrophoresis and Western blotting. The proteinselectrophoresis from the total homogenate has as the purposeto establish the changes, which are revealed at the proteic levelof fibroblasts cultures obtained from rats held on saline minemedium for speleotherapy.
Analysis with GeneTools software v. 4 from SynGene ofeach track of the electrophoresis allowed us to compare theprofiles of the total proteins expression.
PresenterPresentation Notes29SalinaTurda
Salina Cacica
Salina Dej
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UREE
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ALCALINA74.52546.475-28.0528.0566.2758.2536.318.1547.8544.275-3.5753.57546.21.655.2252.612561.647.3-14.314.354.1757.42521.72510.862552.826.125-26.67526.67533.82518.97545.6522.82568.225.3-42.942.943.4524.7567.6533.82559.9520.07-39.8839.8835.47524.47564.35532.177577.5544.275-33.27533.27572.64.9538.22519.112578.6544.825-33.82533.82570.6757.97541.820.964.62530.525-34.134.146.218.42552.52526.2625UREE4.8688.1883.326.4731.6054.9252.46253.8724.260.3884.260.3880.7760.3884.096.031.945.1451.0552.9951.49754.595.971.385.20.611.990.9955.148.243.15.6430.5033.6031.80154.8686.3621.4945.530.6622.1561.0784.8687.1372.2696.1961.3283.5971.79855.097.6352.5456.030.943.4851.74254.8688.0223.1546.3621.4944.6482.324COLESTEROL3.4253.4253.2500.1750.1750.08752.2052.3222.0890.1170.1160.2330.11652.9022.672.7860.2320.1160.3480.1742.7862.9022.7280.1160.0580.1740.0873.3663.4833.4250.1170.0590.1760.0883.5413.4833.4230.0580.1180.1760.0883.3663.4833.250.1170.1160.2330.11653.3673.6573.3080.290.0590.3490.17453.4253.5413.1920.1160.2330.3490.1745TRIGLICERIDE7.6610.217.662.5502.551.27515.54.2865.19811.21410.30221.51610.7585.288.6637.0213.3831.7415.1242.5625.5596.935.9271.3710.3681.7390.86956.0189.6667.4773.6481.4595.1072.55359.6668.9377.1130.7292.5533.2821.6416.74811.8558.3895.1071.6416.7483.3745.01513.047.2048.0252.18910.2145.1078.66311.948.4813.2770.1823.4591.7295GPT0.52106.611.87106.0811.35117.4358.715-1.224.190.525.411.747.153.575-0.778.5710.4779.2711.1790.4445.22-12.213.447.15825.6419.35844.99822.499-1.0470.012.61971.053.65974.70937.3545-0.522.090.522.611.043.651.825-0.1747.9755.1748.1455.34103.4851.74-0.17138.4547.14138.6247.31185.9392.965-0.5279.6115.7180.1316.2396.3648.18MAGNEZIU13.5713.8813.870.310.30.610.30513.9814.2714.1320.290.1520.4420.22113.7614.0814.030.320.270.590.29513.8814.1714.030.290.150.440.2213.6413.9313.860.290.220.510.25513.6313.9413.950.310.320.630.31515.0515.5815.150.530.10.630.31514.414.8914.490.490.090.580.2914.3414.8714.440.530.10.630.315BIOCH2ASMATICI (ovalbumina)NORMALI (sanatosi clinic) Asmatici tratati in Salina Turda
PresenterPresentation Notes34Asmatici tratati in Salina CACICAASMATICI (ovalbumina)NORMALI (sanatosi clinic)
Asmatici tratati in Salina DEJASMATICI (ovalbumina)NORMALI (sanatosi clinic)
155130
160
0
50
100
150
200pr
otei
n am
ount
sample
Total amount of proteins (yg) / 10 yl
Series1
Series1 155 130 160
1 2 3
Chart2155130160sampleprotein amountTotal amount of proteins (yg) / 10 ylSheet1155130160controlOvalbuminTurdaSheet1sampleprotein amountTotal amount of proteins (yg) / 10 ylSheet2Sheet3Phase contrast microscopy analyses of primary fibroblastscultures reveals an cellular regeneration after animal exposureto saline medium in Turda, Cacica and Dej Salt Mines,comparative with the cells morphology of cultures fromOvalbumin sensitised rats.
The morphological observations are confirmed by theelectrophoretic analyses, which demonstrate through rising ofthe expression of many proteins and of total protein amount thatthe exposure of Ovalbumin-sensitised animals to the salinemedium from Turda, Cacica and Dej Salt Mines is reversing thecells morphopathology of pulmonary fibroblasts in cultures;
Wistar rats sensitised with Ovalbumin have a low numberpulmonary fibroblasts output cultures, with a more sensitivemorphopatologic level.
Conclusions
AbstractObjective: Exploring the speleotherapy effects on
morphology and physiology of dermal and pulmonary fibroblastobtained from Wistar rats tissue in normal conditions and afterinduction of experimental astma awareness with ovalbumin.
Exploration of the speleotherapeutic potential through the cellular and molecular biology techniques
Munteanu C., Munteanu D., Simionca I., Cinteza D., Hoteteu M.;
Materials and methods:
Dermal and pulmonaryfibroblast cultures were initiated by enzymatic techniques from appropriate tissue taken of each group Wistar rats. Morphological monitoring was done by phase contast microscopy; biochemical and molecular changes of cultures obtained from animals treated speleothropic compared to control, was experimental establised by electrophoresis and Western Blotting techniques.
Results: Experimental data revealed the expression of several proteins after the speleotherapeutic treatment. These data were analysed compared with control, using a specific software.
Conclusions: Speleotherapeutic treatment of Wistar rats caused significant differences in morphology and protein expression of dermal and pulmonary fibroblatst grown in the laboratory. These differences support the protective effects of speleotherapy compared with data obtained from animals untreated and sensitized with ovalbumin, having induced experimental asthma status.
Studii Avansate la nivel celular si molecular
Studiile celulare si moleculare permit evaluarea modificarilor morfologiei celulare, sintezei proteice, secretia anumitor substante, modificarea metabolismului celular, interactiunea receptorilor celulari cu diferite semnale chimice din mediu, diviziunea celulara si alte procese fiziologice sub influenta directa a factorilor naturali terapeutici introdusi in mediul de cultivare a celulelor.
PresenterPresentation NotesIt is true that the balneological, hydrological, climatological treatment methods are leading for the (traditional) definition of the field.Asociatia Romana de Balneologie / Romanian Association of Balneology
PresenterPresentation NotesIt is true that the balneological, hydrological, climatological treatment methods are leading for the (traditional) definition of the field.TOP 10 Balneo Resorts of Romania
No.
Statiunea BALNEARA C1 C2 C3 C4 C5 C6 C7 C8 C9
C10
Total
1 Techirghiol 7 8 8 8 8 7 5 5 6 8 70
2 Bile Felix 7 7 8 7 6 7 7 7 7 6 69
3 Bile Tunad 6 8 7 7 7 7 6 7 7 6 68
4 Sovata 6 5 7 7 7 7 7 7 5 7 65
5 Bile Herculane 6 5 6 6 7 6 7 7 6 6 64
6 Covasna 5 5 6 6 7 6 6 5 5 6 57
7 Slnic Moldova 5 5 5 5 6 6 6 6 6 6 56
8 Climneti-Cciulata 5 4 6 6 6 5 5 6 6 6 55
9 Neptun 7 4 6 5 5 4 7 5 6 5 54
10 Amara 5 4 5 6 5 5 5 5 5 5 50
Criterii de evaluare:
1. Accesibilitate, infrastructura, patrimoniu public, management urbanistic, implicarea autoritatilor locale: 2. Existena unor structuri de educaie i cercetare, prezena unui personal universitar n staiune, existena unui nucleu de cercetare tiinific;3. Notorietatea extern: spoturi video n engleza, situri web n englez, participarea la targuri internaionale, articole tiinifice n limba englez, participarea la evenimente internaionale, legaturi externe, tour-operatori intarnionali, investitori externi;4. Notorietatea intern a staiunii: organizarea unor evenimente specifice promovarii sectorului balnear, participarea la targuri interne de turism, articole i materiale de promovare n limba romn, situri de promovare;5. Calitatea certificata a factorilor naturali de cur utilizai n staiunea balnear analizat;6. Calitatea serviciilor turistice i medicale din cadrul staiunii balneare analizate, nivelul de calificare a resurselor umane, prezena animatorilor de staiune;7. Strategii de dezvoltare a staiunii identificate prin planuri ale autoritilor locale i ale operatorilor din staiunea balnear analizat;8. Nivelul investiiilor n baze de tratament i uniti de cazare la nivelul staiunii balneare analizate;9. Disponibilitate la dialog a factorilor de decizie locali i a investitorilor / operatorilor economici din staiune;10. Premii tiinifice, medalii, menionri ale staiunii n documente ale autoritilor centrale, vizibilitate a nivelului de excelen al staiunii balneare analizate.
TOP 10 Statiuni Balneare
For health.
For beauty ..
Constantin Munteanu
Romanian Association of Balneology
www.bioclima.roEmail: [email protected]
THANK YOU !
Resurse naturale terapeutice din Romania Slide Number 2BALNEOTERAPIASlide Number 4Slide Number 5Conceptul de STATIUNE BALNEARABALNEOLOGIE si Recuperare medicala in bolile cardiovasculareTratamentul balnear in afectiuni cardiovasculareCovasnaBaile TusnadSlide Number 11BALNEOLOGIE si Recuperare medicala in afectiuni reumatismaleSlide Number 13Slide Number 14Baile FelixSlide Number 16Slide Number 17Slide Number 18Slide Number 19Slide Number 20Slide Number 21Slide Number 22Slide Number 23Slide Number 24Slide Number 25Slide Number 26Slide Number 27Slide Number 28Slide Number 29Slide Number 30Slide Number 31Slide Number 32Slide Number 33Slide Number 34Slide Number 35Slide Number 36Slide Number 37Slide Number 38Slide Number 39Slide Number 40Slide Number 41Studii Avansate la nivel celular si molecularSlide Number 43Slide Number 44Slide Number 45Slide Number 46Slide Number 47For health.For beauty .. Slide Number 50