Research Report 2016–2017Research Report 2016–2017

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Fakultät für Chemie und Pharmazie

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Research Report

Faculty of Chemistry and Pharmacy 2016 - 2017 Volume 14

Ludwig-Maximilians-Universität München

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Publisher: Faculty of Chemistry and Pharmacy Ludwig-Maximilians-Universität München München, 2018 Group leaders are responsible for the contents. Co-ordination: Gertrud Adelmann Office of the Dean Faculty of Chemistry and Pharmacy Ludwig-Maximilians-Universität München Butenandtstr. 5–13 (Haus F), 81377 München Print: Hansa Print Service GmbH ein Unternehmen der Wenzel-Gruppe Thalkirchner Str. 72 80337 München

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Dear Reader: Our Faculty has been putting together a research report biennially since 1988 doc-umenting the research activities of its three Departments. This report may also be viewed on the Faculty’s website under http://www.cup.lmu.de</de/forschung. Important factors for conducting successful research have been the establishment of new key professorships, an example of which was the professorship for the Didac-tics of Chemistry, organized through successful applications to various programs one of which was the European Research Council. Among the special awards granted for the work of our faculty members were the Leibniz Prize of the German Research Foundation as well as a European Research Council Advanced Grant for the Chemistry and Biochemistry Departments. Numerous promising young re-searchers, both women and men, have received further honors or have been offered academic positions at renowned research institutions. Our donors, whom we thank for their engagement in the Römer- and Marcinek Endowments, have made another important contribution to the maintenance of a stimulating research climate. To assure future progress, we are currently building new premises for researchers at the new Institute for Chemical Epigenetics Munich (ICEM). The training of young academics is especially important to foster creative and com-petitive research. Within the last two years, the quality of our study programs has been officially recognized through accreditation and the education of our students has profited by grants from the State and from the Contract for Quality in Teaching (Qualitätspakt Lehre). Personal responsibility, high motivation and drive are the characteristics of our teaching staff, doctoral assistants, students and faculty employees, all of whom have contributed to the outstanding results documented in this report. My thanks to all members of the Faculty, the President’s Office and the State of Bavaria.

Dean of Faculty of Chemistry and Pharmacy

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The following belong to the Faculty of Chemistry and Pharmacy: Department of Biochemistry Feodor-Lynen-Straße 25, Haus A 81377 München tel. 089/2180-0 Department of Chemistry Butenandtstraße 5–13 81377 München tel. 089/2180-0 Inorganic Chemistry: Haus D Organic Chemistry: Haus F Physical Chemistry: Haus E Theoretical Chemistry: Haus E and B Department of Pharmacy – Center for Pharmaceutical Research Butenandtstr. 5–13 81377 München tel. 089/2180-0 Pharmaceutical/Medicinal/Biological Chemistry: Haus C Pharmaceutical Biology and Biotechnology: Haus B and D Pharmaceutical Technology and Biopharmaceutics: Haus B Pharmacology: Haus C

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Inorganic Chemistry Pages Beck, Wolfgang 2–3 Böttcher Hans-Christian 4–5 Bräuniger, Thomas 6–7 Daumann, Lena 8–9 Hoch, Constantin 10–11 Johrendt, Dirk 12–14 Karaghiosoff, Konstantin 15–20 Klapötke, Thomas 21–29 Klüfers, Peter 30–34 Kornath, Andreas 35–36 Lotsch, Bettina 37–42 Schnick, Wolfgang 43–47 Schwarzer, Stefan 48–49 Stierstorfer, Jörg 50–51 Sünkel, Karlheinz 52 Biochemistry Beckmann, Roland 53–57 Canzar, Stefan 58–59 Conti, Elena 60–62 Fässler, Reinhold 63–65 Förstemann, Klaus 66–67 Gaul, Ulrike 68–70 Hartl, F. Ulrich 71–74 Hopfner, Karl-Peter 75–78 Jae, Lucas 79–80 Mann, Matthias 81–89 Schäffner, Anton 90–91 Stingele, Julian 92 Turck, Christoph 93–95 Wilson, Daniel 96–99

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Organic Chemistry Carell, Thomas 100–103 Didier, Dorian 104–105 Dube, Henry 106–107 Hoffmann-Röder, Anja 108–109 Kellner, Stefanie 110–111 Knochel, Paul 112–118 Langhals, Heinz 119–121 Linser, Rasmus 122–124 Magauer, Thomas 125–126 Mayr, Herbert 127–129 Ofial, Armin 130–131 Trapp, Oliver 132–135 Zipse, Hendrik 136–138 Physical Chemistry Bein, Thomas 139–146 Bräuchle, Christoph 147–150 Ebert, Hubert 151–156 Engelke, Hanna 157–158 Hartschuh, Achim 159–160 Jagau, Thomas-Christian 161–162 Ochsenfeld, Christian 163–167 Tinnefeld, Philip 168–169 de Vivie-Riedle, Regina 170–173 Wintterlin, Joost 174–175

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Pharmaceutical/Medicinal/Biological Chemistry Bracher, Franz 176–180 Huc, Ivan 181–184 Thorn-Seshold, Oliver 185 Wanner, Klaus 186–189 Pharmaceutical Biology and Biotechnology Lächelt, Ulrich 190–192 Pachmayr, Johanna 193–194 Vollmar, Angelika 195–199 Wagner, Ernst 200–206 Zahler, Stefan 207–209 Pharmaceutical Technology and Biopharmaceutics Engert, Julia 210–211 Frieß, Wolfgang 212–214 Merkel, Olivia 215–217 Winter, Gerhard 218–221 Pharmacology Biel, Martin 222–227 Grimm, Christian Michael 228–229 Michalakis, Stylianos 230–233 Wahl-Schott, Christian 234–237

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Inorganic Chemistry Univ-Prof. Dr. rer.nat. Dr. h.c. Wolfgang Beck, em. Born 1932 in München, study of chemistry at Technische Hochschule München (now TUM), 1960 PhD degree with Professor Walter Hieber, 1963 Habilitation and Privatdozent at TH München, since 1968 o. Professor and Vorstand of Institut für Anorganische Chemie LMU München, 1973-1974 Dean of Fakultät für Chemie und Pharmazie, 1977 Guest Professor at University of Wisconsin, Madison, 1992-1994 Member of Senat and Versammlung at LMU, 1981-1992 Referee of Deutsche Forschungsgemeinschaft, since 2000 Emeritus, 2011 Dr. h.c. TU München. Research Topics Organometallic and Coordination Chemistry. History of Chemistry at LMU Honors, Awards, Memberships GDCH, American Chemical Society, The Royal Society of Chemistry Publications - Scientific Papers Peter M. Fritz and Wolfgang Beck. Organometallic Lewis Acids LX. Pentacarbon-ylrhenium Complexes [(OC)5Re-L]+ BF4

– with N-Donor Ligands L = Tetrazole, Dimethylaminopyridine (DMAP), Triphenyliminophosphoranes and with Triphenylphosphine Oxide. Z. Anorg. Allg. Chem. 2017, 643, 224-226. Peter M. Fritz and Wolfgang Beck. Organometallic Lewis Acids LXI. Pentacarbonylrhenium Complexes [(OC)5Re-L]+ BF4

– with Aromatic Amines (L) ás Ligands. Z. Anorg. Allg. Chem. 2017, 643, 225-227. Wolfgang Beck, Gerd Fischer and Peter Swoboda, Some Comments on Fulminic Acid (Knallsäure) and a Praise to Heinrich Wieland and his Work on Organic De-rivatives of Nitrogen. Z. Anorg. Allg. Chem. 2017, 643, 353-356.

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Barbara Wagner-Schuh and Wolfgang Beck. Metal Complexes of Biological Im-portant Ligands CLXXVII. Dichlorido Platinum(II) and Palladium(II) Complexes with Long Chain Amino Acids and Amino Acid Amides. Z. Anorg. Allg. Chem. 2017, 643, 632-635. Christopher U. Missling, Karlheinz Sünkel, Heinz Langhals and Wolfgang Beck. Organometllic Lewis Acids, Part LXII. Chiral Carbonyl-Cyclopentadienyl-Triphenylphosphine-Iron and –Ruthenium Complexes with Tertiary Nitriles [CpM(CO)(PPh3)(N C-CR1R2R3)]+ BF4

– . Z. Anorg. Allg. Chem. 2017, 643, 1262-1268. Martin J. Schweiger and Wolfgang Beck. Metal Complexes of Biologically Im-portant Ligands CLXXVIII. Addition of the Pentacarbonylrhenium Cation [(OC) 5Re]+ to the Xanthine Alkaloids Caffeine, Theophylline and Theobromine. Z. Anorg. Allg. Chem. 2017, 643, 1335- 1337. Hans-Christian Böttcher and Wolfgang Beck. Reaction behavior of the Collman reagent towards the nitrosyl carbonyls [CoNO(CO)3] and [Fe(NO)2(CO)2]. Z. Naturforsch. 2017, 72 b, 457-460.

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Inorganic Chemistry Apl. Prof. Dr. rer. nat. Hans-Christian Böttcher Born in 1957 in Zwickau, 1978-1983 studied chemistry at the Martin Luther Uni-versity Halle-Wittenberg, 1985 PhD degree in the group of B. Walther (metal- clus-ter chemistry), scientific assistant at the University of Halle, 1991-1992 postdoctor-al fellow in the group of Prof. G. Süss-Fink at the University of Neuchâ-tel/Switzerland (homogenous catalysis), 1992-1993 research in homogenous cataly-sis for BASF-AG/Ludwigshafen (at the University of Neuchâtel), 1995 research in the group of Prof. R. Schmutzler (Technical University of Braunschweig), 1996 habilitation at the University of Halle (coordinatively unsaturated metal-cluster compounds), privatdozent (C2) in Halle, 1999 interim professor (C4) at the Univer-sity of Karlsruhe (TH), since 2004 scientific assistant at the Department of Chemis-try at LMU Munich (group of Prof. P. Klüfers), since 2005 privatdozent in Munich, since 2011 apl. prof. at the Department of Chemistry in Munich. Research Topics Fixation and activation of small molecules in the coordination sphere of di- and multinuclear metal carbonyl complexes. Protonation of metal-metal bonds in dinu-clear metal complexes. Synthesis of coordination compounds containing nitrosyl ligands. Hyponitrito complexes as model compounds of active sites in processes of enzymatic nitric oxide reductases (NOR). Studies of dynamic effects in complexes with sterically demanding phosphane ligands using NMR spectroscopy (rhodium, iridium). Honors, Awards, Memberships Member of the Gesellschaft Deutscher Chemiker Publications Scientific Papers Synthesis and Molecular Structure of trans-[RhCl(NO)(PtBu2H)2]BF4. H.-C. Böt-tcher, P. Mayer, Z. Anorg Allg. Chem. 2016, 642, 299 301.

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Synthesis and Molecular Structure of trans-[IrCl(NO)(PtBu2H)2]BF4. H.-C. Böt-tcher, T. Mies, P. Mayer, Z. Anorg Allg. Chem. 2016, 642, 793 795. Reaction Behavior of Decacarbonyldimetalates(2 ) (M = Cr and Mo) towards the Nitrosyl Carbonyls of Iron and Cobalt. H.-C. Böttcher, Z. Anorg. Allg. Chem. 2017, 643, 410 412. Reaction Behavior of the Collman reagent towards the nitrosyl carbonyls [CoNO(CO)3] and [Fe(NO)2(CO)2]. H.-C. Böttcher, W. Beck, Z. Naturforsch. 2017, 72b, 457 460. Conformational Rigidity in Complexes [MCl(tBu2PH)3] (M = Rh, Ir). H.-C. Böt-tcher, P. Mayer, Z. Anorg. Allg. Chem. 2017, 643, 1107-1111. Synthesis and Molecular Structures of [Rh(η5-C5H5)(coe)2] (coe = cis-cyclooctene) and [Rh(η5-C5H5)(cod)] (cod = cis,cis-η4-1,5-cyclooctadiene). M. Graf, H.-C. Bött-cher, P. Mayer, M. Scheer, Z. Anorg. Allg. Chem. 2017, 643, 1323-1325.

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Inorganic Chemistry Dr. Thomas Bräuniger Born 1968 in Dresden/Germany, 1988-1993 study of chemistry at Humboldt and Technical University Berlin, 1993-1994 M. Sc. student at the University of Okla-homa, Norman (USA), 1995-2000 Ph. D. student at The Weizmann Institute, Re-hovot (Israel), 2001-2002 postdoctoral fellow at the University of Durham (UK), 2003-2008 postdoctoral fellow and project leader at the University of Halle-Wittenberg, 2009-2013 Head of NMR group at the Max-Planck-Institute for Solid-State Research, Stuttgart, since June 2013 Head of Solid-State NMR at the Inorgan-ic Chemistry Department (AK Schnick) at LMU Munich. Research Topics Application of solid-state NMR spectroscopy for characterization of structure and dynamics of (mostly) inorganic samples. NMR studies of lithium dynamics via analysis of relaxation time and/or line shape. Precise determination of NMR inter-action tensors using rotation pattern analysis of natural and synthetic single crys-tals. Publications – Scientific Papers T. Bräuniger, A. J. Hofmann, I. L. Moudrakovski, C. Hoch, W. Schnick, “A 45Sc-NMR and DFT calculation study of crystalline scandium compounds”, Solid State Sciences 51, 1–7 (2016) B. Matović, M. Prekajski, J. Pantić, T. Bräuniger, M. Rosić, D. Zagorac, D. Milivojević, “Sythesis and densification of single-phase mayenite (C12A7)”, J. Europ. Ceram. Soc. 36, 4237–4241 (2016) A. Haffner, T. Bräuniger, D. Johrendt, “Supertetrahedral networks and lithium-ion mobility in Li2SiP2 and LiSi2P3 ”, Angew. Chem. Int. Ed. 55, 13585–13588 (2016) T. Bräuniger, B. Groh, I. L. Moudrakovski, S. Indris, “Local electronic structure in -LiAlO2 studied by single-crystal 27Al-NMR and DFT calculations”, J. Phys.

Chem. A 120, 7839–7846 (2016)

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L. Neudert, F. Heinke, T. Bräuniger, F. J. Pucher, G. B. Vaughan, O. Oeckler, W. Schnick, “An unusual nitride network of aluminum-centered octa-hedra and phosphoruscentered tetrahedra and structure determination from micro-crystalline samples”, Chem. Commun. 53, 2709–2712 (2017) E.-M. Bertschler, T. Bräuniger, C. Dietrich, J. Janek, W. Schnick, “Li47B3P14N42 – A lithium nitridoborophosphate with [P3N9]12-, [P4N10]10-, and the unprecedented [B3P3N13]15- ion”, Angew. Chem. Int. Ed. 56, 4806–4809 (2017) O. E. O. Zeman, I. L. Moudrakovski, C. Hoch, R. Hochleitner, W. W. Schmahl, K. Karaghiosoff, T. Bräuniger, “Determination of the 31P and 207Pb chemical shift ten-sor in pyromorphite, Pb5(PO4)3Cl, by single-crystal NMR measurements and DFT calculations”, Z. Anorg. Allg. Chem. 643, 1635—1641 (2017) Other Activities Grant reviewer for Deutsche Forschungsgemeinschaft (DFG), Reviewer for Scien-tific Journals: Solid State Nuclear Magnetic Resonance, Magnetic Resonance in Chemistry, Journal of Solid State Chemistry, Zeitung für Allgemeine und An-gewandte Chemie, Chemistry – a European Journal, Inorganic Chemistry, Journal of Physical Chemistry, Solid State Ionics, Solid State Sciences, RSC Advances, RSC Analyst, Physical Review Letters, Zeitschrift für Physikalische Chemie.

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Inorganic Chemistry Prof. Dr. Lena Daumann Born 1983 in Emmendingen, 2003-2009 studied chemistry at Ruprecht-Karls Uni-versity in Heidelberg. Diploma thesis under the supervision of Prof. Dr. Peter Comba. 2009-2010 Intern at BASF SE Ludwigshafen. 2010-2013 PhD in Bioinor-ganic Chemistry under the supervision of Prof. Dr. L.R. Gahan at the University of Queensland in Australia. 2013-2015 Humboldt fellow in the group of Prof. Dr. K. N. Raymond at the University of California in Berkeley, USA. 2015-2016 Hum-boldt fellow with Prof. Dr. P. Comba, Ruprecht-Karls University Heidelberg. 2016-present professor (W2-tt) for bioinorganic and coordination chemistry at LMU Research Topics Coordination chemistry, bioinorganic chemistry, rare earth elements, methanol de-hydrogenase, bioremediation, oxygen activation Honors, Awards, Memberships Society of Biological Inorganic Chemistry (SBIC), Royal Australian Chemical In-stitute Incorporated (RACI), Gesellschaft Deutscher Chemiker e.V., American Chemical Society, Münchener Chemische Gesellschaft Extramural Research Funding SFB749 Startup funding 2016 and 2017. Münchener Universitätsgesellschaft e. V., 2017 DFG DA 1935/1-1, 2017 Publications – Scientific Papers N. Szimhardt, M. H. H. Wurzenberger, A. Beringer, L.J. Daumann and J. Stier-storfer; Coordination chemistry with 1-methyl-5H-tetrazole: Cocrystallization, la-ser-ignition, lead-free primary explosives – One Ligand, three Goals, Journal of Materials Chemistry A, 2017, 5, 23753 – 23765

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D. Fantin, M. Sutton, L.J. Daumann, K.F. Fischer; Evaluation of Existing and New Periodic Tables of the Elements for the Chemistry Education of Blind Students, J. Chem. Educ., 2016, 93 (6), pp 1039–104. L J. Daumann, P. Werther, M. Ziegler, K.N. Raymond; Siderophore inspired tetra- and octadentate antenna ligands for luminescent Eu(III) and Tb(III) complexes, J. Inorg Biochem. 2016 162:263-273. L.J. Daumann, D.S. Tatum, C.M. Andolina, J.I. Pacold, A. D’Aléo, G.-l. Law, J. Xu, K.N. Raymond; Effects of ligand geometry on the photophysical properties of photoluminescent Eu(III) and Sm(III) 1-hydroxypyridin-2-one complexes in aque-ous solution, Inorganic Chemistry, 2016, 55, 114–124.

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Inorganic Chemistry Dr. rer. nat. Constantin Hoch

Born 1971 in Rodalben/Rheinland-Pfalz, 1993 – 1999 studies of chemistry at the University of Freiburg im Breisgau, 1999 diploma and 2003 PhD degree in the group of Prof. Dr.-Ing. Caroline Röhr at University of Freiburg im Breisgau, 2004 – 2006 Postdoctoral fellow at Max-Planck-Institut für Festkörperforschung in Stuttgart in the group of Prof. Dr. Arndt Simon, 2006 – 2011 research assistant and leader of the single crystallography service of Simons group. 2011 – 2012 research assistant at University of Stuttgart in the group of Prof. Dr. Thomas Schleid. Since 01.04.2012 scientific coworker and Habilitand at the chair of inorganic solid state chemistry in the department of chemistry at LMU München, mentored by Prof. Dr. Wolfgang Schnick. Research Topics Intermetallic chemistry, polar metal-metal bonding, bad metal behaviour, amal-gams of less noble metals, electrocrystallisation of intermetallic compounds at low temperatures from aprotic polar solutions. Subvalent alkali and alkaline earth metal compounds, suboxometallates, subnitrido-metallates, solid state syntheses at low temperatures. Solvates of thermodynamically less stable metal halides and their de-composition to the binary halides. Novel cathode materials for lithium ion batteries with high cycle life. X-ray single crystal structure analyses, crystal growth, thermo-analysis, band structure calculations, thermoanalysis, structure-property relations. Publications – Scientific Papers J. Sappl, R. Freund, C. Hoch, "Stuck in our teeth? Crystal structure of a new copper amalgam, Cu3Hg", Crystals 7 (2017), 352. O. E. O. Zeman, I. Moudrakovski, C. Hoch, R. Hochleitner, W. W. Schmahl, K. Karaghiosoff, Th. Bräuniger, "Determination of the 31P and 207Pb chemical shift tensors in pyromorphite, Pb5(PO4)3Cl, by single-crystal NMR measurements and DFT calculations", Z. Anorg. Allg. Chem. 643 (2017), 1635-1641.

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F. Tambornino, C. Hoch, "The simplest representative of a complex series: the Hg-rich amalgam Yb11Hg54", Z. Kristallogr. 232 (2017), 557-565. M. Wörsching, M. Daiger, C. Hoch, "The triple salt Sr14[Ta4N13][TaN4]O - a nitri-dotantalate oxide with 19-fold rocksalt superstructure", Inorg. Chem. 56 (2017), 2941-2948 . 2016 F. Tambornino, J. Sappl, F. Pultar, T. M. Cong, S. Hübner, T. Giftthaler, C. Hoch, "Electrocrystallization - a synthetic method for intermetallic phases with polar met-al-metal bonding", Inorg. Chem. 55 (2016), 11551-11559. M. Wörsching, F. Tambornino, S. Datz, C. Hoch, "Chemical Twinning of Salt and Metal in the Subnitridometalates Ba23Na11(MN4)4 with M = V, Nb, Ta", Angew. Chem. 128 (2016), 11026-11030; Angew. Chem. Int. Ed. 55 (2016), 10868-10871. F. Tambornino, K. Schwärzer, C. Hoch, "Synthesis and characterization of La11+xHg45-x and RE11Hg45.5 (RE = Sm, Nd) as hettotypes of the Sm11Cd45 structure type", J. Solid State Chem. 242 (2016), 162-169. T. Bräuniger, A. J. Hofmann, I. L. Moudrakovski, C. Hoch, W. Schnick, "A 45Sc-NMR and DFT calculation study of crystalline scandium compounds", Solid State Sci. 51 (2016), 1-7. A. Marchuk, P. Schultz, C. Hoch, O. Oeckler, W. Schnick, "M2PO3N (M = Ca, Sr) - ortho-Oxonitridophosphates with β-K2SO4 Structure Type", Inorg. Chem. 55 (2016), 974-982.

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Inorganic Chemistry Univ.-Prof. Dr. Dirk Johrendt Born 1963 in Oberhausen/NRW, 1984-1990 study of chemistry at Universität zu Köln, 1993 PhD in the group of Prof. A. Mewis, Inorganic Chemistry at Universität zu Köln, 1995-1996 Postdoctoral fellow in the group of Jean Rouxel at IMS CNRS Nantes (France); 1997-2002 Assistant professor (C1) at Universität Düsseldorf, Habilitation in inorganic chemistry 2001, since 2002 C3-professor for inorganic solid state chemistry at LMU München. Research Topics Our research at the interface of solid-state chemistry, physics and materials science, is focused on crystal chemistry - physical property relations in inorganic com-pounds. One special interest concerns materials with highly correlated electrons, among them magnetic compounds, Mott insulators, and iron based high-Tc super-conductors. Our main tasks are discovery of new materials with so far unknown crystal structures and compositional tuning of the properties of existing materials through solid solution. We extensively research iron-arsenide and -selenide superconductors focusing on both basic and application-oriented aspects. Honors, Awards, Memberships Offer for a chair (W3) in Inorganic Chemistry at Universität zu Köln (declined) M2S International Advisory Committee EUCAR Conference International Advisory Committee Deutscher Hochschulverband Deutsche Physikalische Gesellschaft Gesellschaft Deutscher Chemiker Münchener Chemische Gesellschaft Extramural Research Funding DFG: Effects of compensating doping or chemical pressure in 122-type supercon-ductors and structure-property relations of superconducting platinum-iron ar-senides with layered structures

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DFG: Superconducting iron-selenide-metal-oxide layered systems by hydrothermal syntheses Publications A. Haffner, T. Bräuniger, D. Johrendt, Supertetrahedral Networks and Lithium-Ion Mobility in Li2SiP2 and LiSi2P3, Angew. Chem. Int. Ed. 2016, 55, 13585-13588. U. Pachmayr, N. Fehn, D. Johrendt, Structural transition and superconductivity in hydrothermally synthesized FeX (X = S, Se), Chem. Commun. 2016, 52, 194-197. S. Holenstein, U. Pachmayr, Z. Guguchia, S. Kamusella, R. Khasanov, A. Amato, C. Baines, H. H. Klauss, E. Morenzoni, D. Johrendt, H. Luetkens, Coexistence of low-moment magnetism and superconductivity in tetragonal FeS and suppression of Tc under pressure, Phys. Rev. B 2016, 93,140506. T. Bartsch, O. Niehaus, R. D. Hoffmann, M. Bartsch, H. Zacharias, D. Johrendt, R. Pöttgen, Palladium pnictide oxides Nd10Pd3As8O10 and Sm10Pd3As8O10 - low tem-perature structural phase transition and physical properties, J. Mater. Chem. C 2016, 4, 6727-6741. C. Benndorf, A. Hohmann, P. Schmidt, H. Eckert, D. Johrendt, K. Schafer, R. Pöttgen, 2D P-31 solid state NMR spectroscopy, electronic structure and thermo-chemistry of PbP7, J. Solid State Chem. 2016, 235, 139-144. F. Caglieris, A. Sala, M. Fujioka, F. Hummel, I. Pallecchi, G. Lamura, D. Johrendt, Y. Takano, S. Ishida, A. Iyo, H. Eisaki, H. Ogino, H. Yakita, J. Shimoyama, M. Putti, Research Update: Structural and transport properties of (Ca,La)FeAs2 single crystal, APL Mater. 2016, 4, 020702. S. Peschke, D. Johrendt, The modulated structures of La2-xPrxO2MnSe2 (0 < x < 1) and La2-xNdxO2MnSe2 (0 <= x <= 0.6), Z. Kristallogr. 2016, 231, 89-95. J. Stahl, V. Pomjakushin, D. Johrendt, Ferromagnetism in Fe3-x-yNixGeTe2, Z. Naturforsch. B 2016, 71, 273-276. T. Bartsch, D. Johrendt, R. Pöttgen, Dimensionality of the oxidic layers in pnictide oxides and transition metal p-element ordering in tetrelides and pnictides, Phys. Stat. Sol. B 2017, 254.

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B. Büchner, R. Hackl, D. Johrendt, High-temperature superconductivity in iron-based compounds Preface, Phys. Stat. Sol. B 2017, 254. D. Contarino, C. Löhnert, D. Johrendt, A. Genovese, C. Bernini, A. Malagoli, M. Putti, Development and Characterization of P-doped Ba-122 Superconducting Tapes, IEEE Trans. Appl. Superconduct. 2017, 27, 4. V. Hlukhyy, A. V. Hoffmann, V. Grinenko, J. Scheiter, F. Hummel, D. Johrendt, T. F. Fässler, Structural instability and superconductivity in the solid solution SrNi2(P1-xGex)2, Phys. Stat. Sol. B 2017, 254. P. Müller, Y. Koval, I. Lazareva, C. Steiner, S. Wurmehl, B. Büchner, T. Stürzer, D. Johrendt, C-axis transport of pnictide superconductors, Phys. Stat. Sol. B 2017, 254. S. Peschke, L. Gamperl, V. Weippert, D. Johrendt, Flux synthesis, crystal struc-tures, and physical properties of new lanthanum vanadium oxyselenides, Dalton Trans. 2017, 46, 6230-6243. S. Peschke, D. Johrendt, Flux Synthesis, Crystal Structures, and Magnetism of the Series La2n+2MnSen+2O2n+2 (n = 0-2), Inorganics 2017, 5, 11. S. Peschke, V. Weippert, A. Senyshyn, M. J. Muhlbauer, O. Janka, R. Pöttgen, S. Holenstein, H. Luetkens, D. Johrendt, Flux Synthesis, Crystal Structures, and Mag-netic Ordering of the Rare-Earth Chromium(II) Oxyselenides RE2CrSe2O2 (RE = La-Nd), Inorg. Chem. 2017, 56, 2241-2247. M. K. Schmitt, O. Janka, R. Pottgen, C. Benndorf, M. de Oliveira, H. Eckert, F. Pielnhofer, A. S. Tragl, R. Weihrich, B. Joachim, D. Johrendt, H. Huppertz, Mo2B4O9-Connecting Borate and Metal-Cluster Chemistry, Angew. Chem. Int. Ed. 2017, 56, 6449-6453. T. Stürzer, C. Stürzer, D. Johrendt, Iron arsenide superconductors (CaFeAs)10MnAs8 with metallic interlayers (M= Pt, Pd; n=3, 4), Phys. Stat. Sol. B 2017, 254.

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Inorganic Chemistry Apl. Prof. Dr. rer. nat. Konstantin Karaghiosoff Born 1956 in Sofia (Bulgaria), 1975-1981 study of chemistry at Ludwig-Maximilian University in Munich, 1986 PhD degree in the group of Prof. Dr. Al-fred Schmidpeter, LMU Munich (Heterophospholes), 1997 habilitation at LMU Munich in inorganic chemistry (Diversity of a simple motif: (RP)nSem rings), 1999-2001 representation of a C3 professorship in inorganic chemistry at LMU, 2000 teaching authorization for inorganic chemistry and appointment as Privatdozent at LMU, 2006 appointment as apl. Professor for inorganic chemistry at LMU. Research Topics Phosphorus sulfur, phosphorus selenium and phosphorus tellurium heterocycles, quasi-binary and binary phosphorus chalcogen cations, selenophosphinates and se-leno-phosphonates, thio-, seleno- and tellurophosphates, heterophospholes, func-tionalized and electron rich phosphines, fluorescent phosphine complexes, NMR spectroscopy of main group elements and metals, analysis of the NMR spectra of high order spin systems and isotopomeric systems, multinuclear NMR spectroscopy of colloids, inorganic frameworks with phosphonates and phosphinates, phospho-nate based porous materials. Honors, Awards, Memberships Member of the German Chemical Society (GDCh) Member of the Munich Chemical Society (MChG) Member of the Section “Magnetic Resonance” of the German Chemical Society Member of the German Association of Universities Publications – Scientific Papers Determination of the 31P and 207Pb Chemical Shift Tensors in Pyromorphite, Pb5(PO4)3Cl, by Single-Crystal NMR Measurements and DFT Calculations. O. E. O. Zeman, I. L. Moudrakovski, C. Hoch, R. Hochleitner, W. W. Schmahl, K. Karaghiosoff, Th. Bräuniger, Z. Anorg. Allg. Chem. 2017, 643, 1635-1641.

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Directed Zincation or Magnesiation of the 2-Pyridone and 2,7-Naphthyridone Scaf-fold Using TMP Bases. D. S. Ziegler, R. Greiner, H. Lumpe, L. Kqiku, K. Karaghiosoff, P. Knochel, Org. Lett. 2017, 19, 5760-5763. Anionic Palladium(0) and Palladium(II) Ate Complexes. M. Kolter, K. Böck, K. Karaghiosoff, K. Koszinowski, Angew. Chem., Int. Ed. 2017, 56, 13244-13248. Synthesis of Bicyclo[1.1.1]pentane Bioisosteres of Internal Alkynes and para-Disubstituted Benzenes from [1.1.1]Propellane. I. S. Makarov, C. E. Brocklehurst, K. Karaghiosoff, G. Koch, P. Knochel, Angew. Chem., Int. Ed. 2017, 56, 12774-12777. Zn-, Mg-, and Li-TMP Bases for the Successive Regioselective Metalations of the 1,5-Naphthyridine Scaffold (TMP=2,2,6,6-Tetramethylpiperidyl). M. Balkenhohl, R. Greiner, I. S. Makarov, B. Heinz, K. Karaghiosoff, H. Zipse, P. Knochel, Chem. Eur. J. 2017, 23, 13046-13050. Synthesis and Utilization of Optically Active α-Aminophosphonate Derivatives by Kabachnik-Fields Reaction. E. Balint, A. Tajti, D. Kalocsai, B. Matravolgyi, K. Karaghiosoff, M. Czugler, G. Keglevich, Tetrahedron 2017, 73, 5659-5667. Synthesis of New Cobalt Aluminophosphate Framework by Opening a Cobalt Me-thylphosphonate Layered Material. M. Zaarour, O. Perez, Ph. Boullay, J. Martens, B. Mihailova, K. Karaghiosoff, L. Palatinus, S. Mintova, CrystEngComm 2017, 19, 5100-5105. Synthesis and Characterization of 2,2'-Dinitramino-5,5'-bi(1-oxa-3,4-diazole) and Derivatives as Economic and Highly Dense Energetic Materials. T. S. Hermann, K. Karaghiosoff, T. M. Klapötke, J. Stierstorfer, Chem. Eur. J. 2017, 23, 12087-12091. Application of Headspace and Direct Immersion Solid-Phase Microextraction in the Analysis of Organothiophosphates Related to the Chemical Weapons Conven-tion From Water and Complex Matrices. M. A. Althoff, A. Bertsch, M. Metzulat, T. M. Klapötke, K. Karaghiosoff, Talanta 2017, 174, 295-300. The Synthesis of α-Aryl-α-aminophosphonates and α-Aryl-α-aminophosphine Oxi-des by the Microwave-Assisted Pudovik Reaction.

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E. Balint, A. Tajti, A. Adam, I. Csontos, K. Karaghiosoff, M. Czugler, P. Abranyi-Balogh, G. Keglevich, Beilstein J. Org. Chem. 2017, 13, 76-86. Selective Lithiation, Magnesiation, and Zincation of Unsymmetrical Azobenzenes Using Continuous Flow. M. Ketels, D. B. Konrad, K. Karaghiosoff, D. Trauner, P. Knochel, Org. Lett. 2017, 19, 1666-1669. Application of the Transpiration Method To Determine the Vapor Pressure and Re-lated Physico-Chemical Data of Low Volatile, Thermolabile, and Toxic Orga-no(thio)phosphates. M. A. Althoff, K. Grieger, M. A. C. Härtel, K. Karaghiosoff, T. M. Klapötke, M. Metzulat, J. Phys. Chem. A 2017, 121, 2603-2609. New Aspects of the Detection and Analysis of Organo(thio)phosphates Related to the Chemical Weapons Convention. M. A. Althoff, A. Bertsch, M. Metzulat, O. Kalthoff, K. Karaghiosoff, Phosphorus, Sulfur, Silicon Relat. Elem. 2017, 192, 149-156. Selective Metalations of 1,4-Dithiins and Condensed Analogues Using TMP-Magnesium and -Zinc Bases. A. Castello-Mico, J. Nafe, K. Higashida, K. Karaghiosoff, M. Gingras, P. Knochel, Org. Lett. 2017, 19, 360-363. Synchronized Offset Stacking: A Concept for Growing Large-Domain and Highly Crystalline 2D Covalent Organic Frameworks. F. Auras, L. Ascherl, A. H. Hakimioun, J. T. Margraf, F. C. Hanusch, S. Reuter, D. Bessinger, M. Döblinger, Ch. Hettstedt, K. Karaghiosoff, S. Herbert, P. Knochel, T. Clark, T. Bein, J. Am. Chem. Soc. 2016, 138, 16703-16710. Synthesis and Characterization of Allyl- and Vinyl-substituted 1,2-Bis(tetrazolo)-ethanes as Polymeric Precursors. V. A. Hartdegen, M. S. Hofmayer, K. Karaghiosoff, T. M. Klapötke, Z. Naturfor-sch., 2016, 71B, 1199-1209. Synthesis and Investigation of Advanced Energetic Materials Based on Bispyra-zolylmethanes. D. Fischer, J. L. Gottfried, T. M. Klapötke, K. Karaghiosoff, J. Stierstorfer, T. G. Witkowski, Angew. Chem., Int. Ed. 2016, 55, 16132-16135. Diastereoselective Cobalt-Mediated Cross-Couplings of Cycloalkyl Iodides with Alkynyl or (Hetero)Aryl Grignard Reagents.

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J. M. Hammann, D. Haas, C.-Ph. Tüllmann, K. Karaghiosoff, P. Knochel, Org. Lett. 2016, 18, 4778-4781. Ambident Reactivity of Acetyl- and Formyl-Stabilized Phosphonium Ylides. P. A. Byrne, K. Karaghiosoff, H. Mayr, J. Am. Chem. Soc. 2016, 138, 11272-11281. Synthesis of Two p-Methoxyphenyl Substituted Phosphines. Ch. Hettstedt, A. Frank, K. Karaghiosoff, Phosphorus, Sulfur, Silicon Relat. Elem. 2016, 191, 1297-1301. One-Pot Synthesis of Substituted Trifluoromethylated 2,3-Dihydro-1H-imidazoles. A. Deutsch, Ch. Jessen, C. Deutsch, K. Karaghiosoff, A. Hoffmann-Röder, Org. Lett. 2016, 18, 3474-3477. Toward Customized Tetrahydropyran Derivatives through Regioselective α-Lithiation and Functionalization of 2-Phenyltetrahydropyran. L. Cicco, V. Addante, A. Temperini, C. A. Donau, K. Karaghiosoff, F. M. Perna, V. Capriati, Eur. J. Org. Chem. 2016, 3157-3161. Stereoselective Synthesis of Secondary Alkyllithiums and Their Application to Ste-reoselective Cuprations or Intramolecular Carbolithiations for the Stereoselective Synthesis of Alkylidenecyclobutanes. K. Moriya, K. Schwärzer, K. Karaghiosoff, P. Knochel, Synthesis 2016, 48, 3141-3154. Synthesis of the First Representatives of Amino Bis(picolyl) and Amino Bis(quinaldinyl) Phosphines. Ch. Hettstedt, P. Köstler, E. Ceylan, K. Karaghiosoff, Tetrahedron 2016, 72, 3162-3170. Sc(OTf)3-Catalyzed Addition of Bromomagnesium 2-Vinyloxy Ethoxide to Va-rious Aldehydes Leading to Protected Aldol Products. P. Quinio, L. Kohout, D. S. Roman, J. Gaar, K. Karaghiosoff, P. Knochel, Synlett 2016, 27, 1715-1719. Polyfunctional Lithium, Magnesium, and Zinc Alkenyl Reagents as Building Blocks for the Synthesis of Complex Heterocycles. Zh.-L.Shen, V. Dhayalan, A. D. Benischke, R. Greiner, K. Karaghiosoff, P. Mayer, P. Knochel, Angew. Chem., Int. Ed. 2016, 55, 5332-5336.

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Diphosphane 2,2'-Binaphtho[1,8-de][1,3,2]dithiaphosphinine and the Easy Forma-tion of a Stable Phosphorus Radical Cation. Ch. Kirst, B. E. Bode, D. B. Cordes, Ph. S. Nejman, A. M. Z. Slawin, K. Karaghio-soff, J. D. Woollins, Dalton Trans. 2016, 45, 6348-6351. Methoxyphenyl Substituted Bis(picolyl)phosphines and Phosphine Oxides. Ch. Hettstedt, M. Unglert, R. J. Mayer, A. Frank, K. Karaghiosoff, Eur. J. Inorg. Chem. 2016, 1405-1414. Lewis Acid Triggered Regioselective Magnesiation and Zincation of Uracils, Uri-dines, and Cytidines. L. Klier, E. Aranzamendi, D. Ziegler, J. Nickel, K. Karaghiosoff, T. Carell, P. Kno-chel, Org. Lett. 2016, 18, 1068-1071. Molecular Docking Sites Designed for the Generation of Highly Crystalline Cova-lent Organic Frameworks. L. Ascherl, T. Sick, J. T. Margraf, S. H. Lapidus, M. Calik, Ch. Hettstedt, K. Kara-ghiosoff, M. Döblinger, T. Clark, K. W. Chapman, F. Auras, T. Bein, Nature Chem. 2016, 8, 310-316. Synthesis, Characterization, and Application of Platinum(II) Complexes Incorpora-ting Racemic and Optically Active 4-Chloro-5-Methyl-1-Phenyl-1,2,3,6-Tetrahydrophosphinine Ligand. P. Bagi, K. Karaghiosoff, M. Czugler, D. Hessz, M. Kallay, M. Kubinyi, T. Szilva-si, P. Pongracz, L. Kollar, I. Timari, K. E. Köver, L. Drahos, E. Fogassy, G. Kegle-vich, Heteroatom Chem. 2016, 27, 91-101. Highly Diastereoselective Approach to Methylenecyclopropanes via Boron-Homologation/Allylboration Sequences. A. N. Baumann, A. Music, K. Karaghiosoff, D. Didier, Chem. Commun. 2016, 52, 2529-2532. A Straightforward Access to Ruthenium-Coordinated Fluorophosphines From Pho-sphorous Oxyacids. F. Delgado Calvo, V. Mirabello, M. Caporali, W. Oberhauser, K. Raltchev, K. Ka-raghiosoff, M. Peruzzini, Dalton Trans. 2016, 45, 2284-2293. Synthesis of 2-Phosphaindolizine and [1,3]Azaphospholo[1,5-a]quinoline. Ch. Hettstedt, R. J. Mayer, J. F. Martens, S. Linert, K. Karaghiosoff, Eur. J. Inorg. Chem. 2016, 726-735.

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Synthesis and Use of α-Aminophosphine Oxides and N,N-Bis(phosphinoylmethyl)-amines - A Study on the Related Ring Platinum Complexes. E. Balint, A. Tripolszky, E. Jablonkai, K. Karaghiosoff, M. Czugler, Z. Mucsi, L. Kollar, P. Pongracz, G. Keglevich, J. Organomet. Chem. 2016, 801, 111-121. Synthesis and Halogen Bonding in the Crystal Structures of the New 2,3-Diiodo Indenone and 1-Ethoxy-2,3-diiodo Indene. Ch. Hettstedt, M. Heuschmann, K. Karaghiosoff, Heteroatom Chem. 2016, 27, 75-82. Preparation of Functionalized 2,7-Naphthyridines by Directed Lithiation with (2,2,6,6-Tetramethylpiperidyl)lithium and Their Regioselective Iron-Catalyzed Cross Couplings. R. Greiner, R. Blanc, Ch. Petermayer, K. Karaghiosoff, P. Knochel, Synlett 2016, 27, 231-236. Optimized Verification Method for Detection of an Albumin-Sulfur Mustard Ad-duct at Cys34 Using a Hybrid Quadrupole Time-of-Flight Tandem Mass Spectro-meter After Direct Plasma Proteolysis. H. John, M. Siegert, F. Gandor, M. Gawlik, A. Kranawetvogl, K. Karaghiosoff, H. Thiermann, Toxicology Lett. 2016, 244, 103-111. Other Activities 2006-2013 vice chairman of the Munich Chemical Society, manager of the NMR facilities, vice chairman of the IT commission of the Faculty of Chemistry and Pharmacy, since 2005 European Editor of Phosphorus, Sulfur, Silicon and the Re-lated Elements.

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Inorganic Chemistry Prof. Dr. rer. nat. Thomas M. Klapötke Thomas M. Klapötke is received his Ph.D. in 1986 (TU Berlin), post-doc in Freder-icton, New Brunswick, habilitation in 1990 (TU Berlin). From 1995 until 1997 Klapötke was Ramsay Professor of Chemistry at the University of Glasgow in Scotland. Since 1997 he has held the Chair of Inorganic Chemistry at LMU Mu-nich. In 2009 Klapötke was appointed a Visiting Professor at CECD, University of Maryland. Klapötke is a Fellow of the RSC (C.Sci., C.Chem. F.R.S.C.), a member of the ACS and the Fluorine Division of the ACS, a member of the GDCh, and a Life Member of both the IPS and the National Defense Industrial Association. Most of Klapötke's scientific collaborations are between LMU and ARL in Aberdeen, MD and ARDEC in Picatinny, NJ. Klapötke also collaborates with ERDC in Champaign, IL. And Prof Ang, How-Ghee (NTU, Singapore). He is the executive editor of Zeitschrift für Anorganische und Allgemeine Chemie, the Subject Editor in the area of explosives synthesis of the Central European Journal of Energetic Materials and an editorial board member of Propellants, Explosives and Pyrotech-nics, the Journal of Energetic Materials, and the International Journal of Energetic Materials and Chemical Propulsion. Klapötke has published over 770 papers, 31 book chapters and 13 books. Research Topics Energetic material, secondary (high) explosives, primary explosives, propellants, propellant charges, rocket propellants, gun propellants, agent defeat weapons, laser initiation, night vision, decoy flares, visible flares, colored smokes, oxidizers, com-putational chemistry (semiempirical, ab initio, DFT), non-metal chemistry, fluorine chemistry. Honors, Awards, Memberships Executive editor of Z. Anorg. Allg. Chem. (ZAAC) Subject editor Central Europ. J. Energ. Mat. (CEJEM) Member of the Editorial Board J. Energetic Materials (JEM) Member of the Editorial Board Propellants Explosives Pyrotechnics (PEP) Member of the Editorial Board J. Fluorine Chem. (JFC) Member of the Editorial Board Bulletin of the Korean Chemical Society

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Member of the following professional societies: RSC (CSci, F.R.S.C., CChem), GDCh, ACS, ACS Fluorine Division, NDIA (life member) DWT, Deutsche Gesellschaft für Wehrtechnik Extramural Research Funding Office of Naval Research (ONR) grant no. ONR.N00014-16-1-2062; Bundesministerium für Bildung und Forschung (BMBF), grant no. 13N12583; Bundeswehr – Wehrtechnische Dienststelle für Waffen und Munition (WTD 91) grant no. E/E91S/FC015/CF049. Publications – Scientific Papers The Reagent-depending Nitration of 1,3-Dihydroxyacetone Dimer, Tobias S. Her-mann,a Thomas M. Klapötke, Burkhard Krumm, J.Stierstorfer, ZAAC, 2017, 643, 149 - 151. Improved Efficiency by Adding 5-Aminotetrazole to Anthraquinone-free New Blue and Green Colored Pyrotechnical Smoke Formulations, J. Glück, T. M. Klapötke, M. Rusan, A. Shaw, Prop. Expl. Pyrotech., 2017, 42, 131 – 141. Synthesis and Investigation of 1,3-Di(5-nitraminotetrazol-1-yl)-propan-2-ole and its Salts, T. M. Klapötke, B. Stiasny, J. Stierstorfer, Z Allg Anorg Chem. 2017, 643, 228–234. Estimated Detonation Velocities for TKX-50, MAD-X1, BDNAPM, BTNPM, TKX-55 and DAAF using the Laser-induced Air Shock from Energetic Materials Technique, J. L. Gottfried, T. M. Klapötke, T. G. Witkowski, Prop. Expl. Pyrotech. 2017, 42, 353 - 359. Gas-phase Concentration of Triacetone Triperoxide (TATP) and Diacetone Diper-oxide (DADP) M. A. C. Härtel, T. M. Klapötke, B. Stiasny, J. Stierstorfer, Prop. Expl. Pyrotech. 2017, 42, 623 - 634. Application of the Transpiration Method To Determine the Vapor Pressure and Re-lated Physico-Chemical Data of Low Volatile, Thermolabile, and Toxic Or-gano(thio)phosphates, M. A. Althoff, K. Grieger,M. A. C. Härtel, K. L. Karaghio-soff, T. M. Klapötke, M. Metzulat, J. Phys. Chem. A, DOI: 10.1021/acs.jpca.7b01177.

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Kinetic parameters of PBX based on cis-1,3,4,6-tetranitroocta-hydroimidazo-[4,5-d] imidazole obtained by isoconversional methods using different thermal analysis techniques, A. Elbeih, M. Abd-Elghany, Thomas M. Klapötke, Prop. Expl. Pyro-tech. 2017, 42, 468 - 476. Study of ammonium perchlorate and tetramethylammonium nitrate based pyrotech-nic blue strobe compositions, D. Juknelevicius, A. Dufter, M. Rusan, T. M. Klapöt-ke, A. Ramanavicius, Eur J Inorg Chem. 2017, 1113–1119. The Energetic 3-Trinitromethyl-5-nitramino-1H-1,2,4-triazole and Nitrogen-rich Salts T. S. Hermann, T. M. Klapötke, B. Krumm, J. Stierstorfer, New J. Chem., 2017, 41, 3068--3072. Highly Energetic Metal Salts and Complexes of 1,1’-Dinitramino-5,5’-bitetrazole, M. F. Bölter, M. Born, T. M. Klapötke, J. Stierstorfer, N. Szimhardt, Dalton Trans. 2017, 46, 5033 - 5040. Aliphatic nitroalkanes: evaluation of thermochemical data with comple mentary experimental and computational methods, Martin Härtel; Jörg Stierstorfer; Thomas M Klapötke, Sergey P. Verevkin Thermochimica Acta, 656 (2017) 151–160. 3-Nitramino-4-nitrofurazan: Enhancing the Stability and Energetic Properties by Introduction of Alkylnitramines, T. M. Klapötke, C. Pflüger, Z. Anorg. Allg. Chem. Z. Anorg. Allg. Chem. 2017, 643, 619–624. Effect of Adding 5-Aminotetrazole to a Modified U.S. Army Terephthalic Acid White Smoke Composition, J. Glück, T. M. Klapötke, A. P. Shaw, Cent. Eur. J. Energ. Mater. 2017, 14(3): 489-500; DOI: 10.22211/cejem/76843. The Exciting Chemistry of 1,1-Diamino-2,2-dinitroethene (FOX-7) and 1-Amino-1-hydrazino-2,2-dinitroethene (HFOX), Q. Axthammer, T. M. Klapötke, B. Krumm, The Journal of Physical Chemistry, 2017, 121, 3567−3579. Di(1H-tetrazolyl-5-yl)methane as Neutral Ligand in Energetic Transition Metal Complexes, M. Freis, T. M. Klapötke, J. Stierstorfer, N. Szimhardt, Inorg. Chem., 2017, 56, 7936−7947. Polyfunctional Energetic Nitrates Derived from Tris(hydroxymethyl)aminomethane (Tris), T. M. Klapötke, B. Krumm, T. Reith, Eur. J Org Chem. 2017, 3666–3673. 125 Years Zeitschrift für Anorganische und Allgemeine Chemie, Editorial, T. F. Fässler, T. M. Klapötke and C. Limberg, Z. Anorg. Allg. Chem. 2017, 406 – 409.

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Study of Thermal Reactivity and Kinetics of HMX and Its PBX by Different Meth-ods, M. Abd-Elghany, T. M. Klapötke, A. Elbeih, S. Hassanwin, T. Elshenawy, Chinese Journal of Explosives & Propellants 2017, 40, 24 32. Investigation of different thermal analysis techniques to determine the decomposi-tion kinetics of ɛ-2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane with reduced sensitivity and its cured PBX, M Abd El Ghani, T. M. Klapötke, A. Elbeih, S. Zeman, Journal of Analytical and Applied Pyrolysis 2017, 126, 267–274. Tetranitromethane–a nightmare of molecular flexibility in the gaseous and solid state, Y. V. Vishnevskiy, D. Tikhonov, J. Schwabedissen, H.-G. Stammler, R. Moll, B. Krumm, T M. Klapötke, N.W. Mitzel, Angew. Chem.Int. Ed. 2017, 56, 9619 – 9623. Fabrication of PAN-TCF-Hydrazone Nanofibers by Solution Blowing Spin-ninTechnique: Naked-eye Colorimetric Sensor, T. Khattab, S. Abd-ElMoez, T. Hamouda, T. M. Klapötke, J. Environmental Chemical Engineering 5 (2017) 2515–2523. Synthesis and properties of 4,4',5,5'-tetranitro-1H,1'H-2,2'-biimidazole salts: semi-carbazidium, (3-amino-1,2,4-triazolium)and (5-aminotetrazolium) derivatives, R. Lewczuk, M. Szala1, J. Rećko1, T. M. Klapötke, S. Cudziło, Chemistry of Hetero-cyclic Compounds 2017 53 (6/7), 697–701. Energetic Materials Designing Bench (EMDB), Version 1.0, M. H. Keshavarz, T. M. Klapötke, M. Suceska, Propellants Explosives Pyrotech-nics 2017, 42, 854–856. Polynitrocarbamates Derived from Nitromethane,T. M. Klapötke, B. Krumm, T. Reith, Z. Anorg. Allg. Chem. 2017, 643, 1474–1481. Investigation of 2,2,2-trinitroethyl-nitrocarbamate as a high energy dense oxidizer and its mixture with Nitrocellulose (thermal behavior and decomposition kinetics), M. Abd-Elghany, T. M. Klapötkea, A. Elbeih, Journal of Analytical and Applied Pyrolysis 2017, 128, 397 – 404.. Recent advances in new oxidizers for solid rocket propulsion, D. Trache, T. M. Klapötke, L. Maiz, M. Abd-Elghany, L. T. DeLuca, Green Chemistry: 2017, 19, 4711–4736. Синтез и свойства солей 4,4',5,5'-тетранитро- 1H,1'H-2,2'-биимидазола – производных семикарбазида, 3-амино-1,2,4-триазола и 5-аминотетразола, Ra-

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fa Lewczuk, Mateusz Szala, Judyta Reko, Thomas M. Klapötke, Stanisaw Cudzio, Chemistry of Heterocyclic Compounds, 2017, 53(6/7), 697. Synthesis and Characterization of 2,2’-Dinitramino-5,5’-bi(1-oxa-3,4-diazole) and Derivatives as Economic and Highly Dense Energetic Materials,T. S. Hermann, K. Karaghiosoff, T. M. Klapötke, J. Stierstorfer, Chemistry – Europ. J., 2017, 23, 12087 – 12091. M42 Primer Processing with Potassium and Copper Salt Formulations. M. M. Pus-zynski, N. Mehta, G. Cheng, K. D. Oyler, D. Fischer, T. M. Klapötke, J. Stierstor-fer; J Inorg Chem. 2016, 1(1): 003. A Strontium- and Chlorine-Free Pyrotechnic Illuminant of High Color Purity, J. Glück, T. M. Klapötke, M. Rusan, J. J. Sabatini, J. Stierstorfer, Angew. Chem. 2017, 129, 16733 –16736, Angew. Chem. Int. Ed. 2017, 56, 16507 –16509. Highly Energetic Peroxy Acids with Low Sensitivities, N.-D. H. Gamage, B. Stiasny, J. Stierstorfer, P. D. Martin, T. M. Klapötke, C. H. Winter,Chem. Europ. J. 2016, 22, 2582 - 2585. Determination of the Initiating Capability of Detonators Containing TKX-50, MAD-X1, PETNC, DAAF, RDX, HMX or PETN as a Base Charge, by Underwa-ter Explosion Test, T. M. Klapötke, T. G. Witkowski, Z. Wilk, J. Hadzik, Prop. Explos. Pyrotech. 2016, 41, 92 - 97. Energetic Materials Based on 5,5'-Diamino-4,4'-dinitramino-3,3'-bi(1,2,4-triazole), T. M. Klapötke, M. Leroux, P. C. Schmid, J. Stierstorfer, Chemistry - An Asian Journal 2016, 11, 844 - 851. Synthesis and Properties of 4,4’,5,5’-Tetranitro-2,2’-biimidazolates: Bis˗semicarbazidium, Bis(3-amino-1,2,4-triazolium), and Bis(5-aminotetrazolium) R. Lewczuk, M. Szala, J. Rećko, T. M. Klapötke, S. Cudziło, Central Europ J En-erg Mat., 2016, 13(3), 612 – 626. Tetranitratoethane, D. Fischer, T. M. Klapötke, J.Stierstorfer, Chem Commun. 2016, 52, 916 - 918. Primary Nitrocarbamates of Sugar Alcohols: From Food to Energetic Materials, Q. Axthammer, T. M. Klapötke, B. Krumm, Chem. Asian J. 2016, 11, 568 - 575.

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Synthesis and Initiation Capabilities of Energetic Diazodinitrophenols, D. Izsák, A. Preimesser, T. M. Klapötke, J. Stierstorfer, Z. Anorg. Allg. Chem. 2016, 642, 48 - 55. Energetic Materials based on 5,7-Dinitrobenzotriazole and 4,6-Dinitrobenzotriazol-3-ium 1-Oxide Derivatives, T. M. Klapötke, C. Pflüger, M. W. Reintinger, Eur. J Inorg. Chem. 2016, 138 - 147. Combining the advantages of tetrazoles and 1,2,3-triazoles: 4,5-bis(tetrazol-5-yl)-1,2,3-triazole, 4,5-bis(1-hydroxytetrazol-5-yl)-1,2,3-triazole and their energetic de-rivatives, A. Dippold, D. Iszak, T. M. Klapötke, C. Pflüger, Chemistry Europ. J. 2016, 22, 1768 - 1778. Selected Nitrocarbamates of Glycerine and Co. and the First Acetylene Derivative, Q. Axthammer, T. M. Klapötke, B. Krumm, Z. Anorg. Allg. Chem. 2016, 642, 211 - 218. Synthesis and Characterization of Tetrahedral Zn(II) Complexes with 3,6,7-Triamino-7H-[1,2,4]triazolo[4,3-b][1,2,4]triazole as Nitrogen-rich Ligand, T. M. Klapötke, P. C. Schmid, J. Stierstorfer, N. Szimhardt, Z. Anorg. Allg. Chem. 2016, 642(5), 383 - 389. Melt-cast Materials: Combining the Advantages of Highly Nitrated Azoles and Open-chain Nitramines, T. M. Klapötke, C. Pflüger, J. Stierstorfer, New Journal of Chemistry, 2016, 40, 6059 - 6069. Novel Ionic and Covalent Insensitive High- Explosives (review), T. M. Klapötke, T. Witkowski, Prop. Expl. Pyrotech, DOI: 10.1002/prep.201600006. Picrylamino-1,2,4-triazole derivatives: thermally stable explosives, Z. L. Chioato, T. M. Klapötke, F. Mieskes, J. Stierstorfer, M. Weyrauther, Eur J Inorg Chem 2016, 956 - 962. 1,1’-Nitramino-5,5’-bitetrazoles, D. Fischer, T. M. Klapötke, J. Stierstorfer, N. Szimhardt, Chemistry Europ J. 2016, 22, 4966 - 4970. Studies on the Synthesis and Properties of 1,1,1-Trinitroprop-2-yl Urea, Carbamate and Nitrocarbamate, Q. J. Axthammer, T. M. Klapötke, B. Krumm, Z. Naturforsch. 2016; 71(7)b, 811–820. 5,5'-Bis(2,4,6-trinitrophenyl)-2,2'-bi(1,3,4-oxadiazole) - TKX-55: Thermally Stable Explosive with Outstanding Properties, T. M. Klapötke, T. Witkowski, Chem. Plus Chem. 2016, 81, 357 - 360.

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Tailoring the Energetic Properties of 5-(5-Amino-1,2,3-triazol-4-yl)tetrazole and its Derivatives by Salt Formation: From Sensitive Primary to Insensitive Secondary Explosives, D. Izsak, T. M. Klapötke, F. H. Lutter, C. Pflüger, Eur. J. Inorg. Chem. 2016, 1720 - 1729. Comment on “A quantitative definition of hypervalency” by M. C. Durrant, Chem. Sci., 2015, 6, 6614, R. D. Harcourt, T. M. Klapötke, Chemical Science 2016, 7, 3443-3447. Electrospun Nanofibers from a Tricyanofuran-Based Molecular Switch for Colori-metric Recognition of Ammonia Gas, T. A. Khattab, S. Abdelmoez, T. M. Klapöt-ke, Chem. Europ. J. 2016, 22, 4157 - 4163. Studies on Energetic Salts based on (2,4,6-Trinitrophenyl)guanidine, T. M. Klapöt-ke, F. Mieskes, Jörg Stierstorfer, M. Weyrauther, Prop. Expl. Pyrotech 2016, 41, 217 - 222. Synthesis and Investigation of 2,6-Bis(picrylamino)-3,5-dinitro-pyridine (PYX) and Salts Thereof, T. M. Klapötke, J. Stierstorfer, M. Weyrauther, T. G. Witkowski, Chem. Europ. J. 2016, 22, 8619 - 8626. Polyurethanes Based on 2,2-Dinitropropane-1,3-diol and 2,2-Bis(azidomethyl)propane-1,3-diol as Potential Energetic Binders, A. B. Bellan, S. Hafner, V. A. Hartdegen, T. M. Klapötke, J.APPL.POLYM.SCI. 2016, DOI: 10.1002/APP.43991 (1 – 9). Energetic Sila-Nitrocarbamates: Silicon Analogues of Neo-Pentane Derivatives, Q. Axthammer, T. M. Klapötke, B. Krumm, T. Reith, Inorg. Chem., 2016, 55, 4683 – 4692. Experimental Study on the Heat Resistant Explosive 5,5'-Bis(2,4,6-trinitrophenyl)-2,2'-bi(1,3,4-oxadiazole) (TKX-55): The Jet Penetration Capability and Underwa-ter Explosion Performances, T. M. KLAPÖTKE, T. G. WITKOWSKI, Z. WILK, J. HADZIK, Central Europ. J. Energ. Mat. 2016, 13(4), 821-837. Oxalyl Chloride and Hydrazide Based Energetic Polynitro Derivatives, T. M. Klapötke, B. Krumm, R. Scharf[, Europ. J. Inorg. Chem. 2016, 3086–3093. Isolation of a Moderately Stable but Sensitive Zwitterionic Diazonium Tetrazolo-1,2,3-triazolate, T. M. Klapötke, B. Krumm, C. Pflüger, J. Org. Chem., 2016, 81, 6123−6127.

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Carbonyl Diisocyanate CO(NCO)2: Synthesis and Structures in Solid State and Gas Phase, T. M. Klapötke, B. Krumm, S. Rest, R. Scharf, J. Schwabedissen, H.-G. Stammler, N. Mitzel, Norbert, J. Phys Chem, A, 2016, 120, 4534−4541. Potential Energetic Plasticizers on the Basis of 2,2-Dinitropropane-1,3-diol and 2,2-Bis(azidomethyl)propane-1,3-diol, S. Hafner, V. A. Hartdegen, M. S. Hofmayer, T. M. Klapötke, Prop. Expl. Pyrotech. 2016, 41, 806 - 813. Synthesis and Characterization of Allyl and Vinyl Based 1,2-Bis(tetrazolo)ethanes as Polymeric Precursors, V. A. Hartdegen, M. S. Hofmayer, K. Karaghiosoff, T. M. Klapötke, Z. Naturforsch B 2016; 71(12)b: 1199–1209. Energetic Materials Trends in 5- and 6-Membered Cyclic Peroxides Containing Hydroperoxy and Hydroxy Substituents, N.-D- H. Gamage, B. Stiasny, E. G. Kratz, J. Stierstorfer, P. D. Martin, G. A. Cisneros, Thomas M. Klapötke, C. H. Winter, Eur. J. Inorg. Chem. 2016, 5036 - 5043. Azido(tert-butylperoxy)methyl compounds - an exceptional class of energetic mate-rials, T. M. Klapötke, T. Rotariu, B. Stiasny, J. Stierstorfer, S. Wiegmann, T. Ze-cheru, Eur. J. Org. Chem. 2016, 4382 - 4386. From Amino Acids to High-Energy Dense Oxidizers: Polynitro Materials Derived from Alanine and L-Aspartic Acid, T. M. Klapötke, B. Krumm, R. Scharf, Z. Anorg. Allg. Chem. 2016, 642, (16), 887–895. Energetic Materials - Nitrated Phenyl Peroxy Anhydrides as Peroxide Based Explo-sives with Relatively High Densities and Thermal Stabilities, T. M. Klapötke, B. Stiasny, Jörg Stierstorfer, Chem. Select., 2016, 1, 4057 – 4061. Reactive Nanocomposites as Versatile Additives for Composite Propellants, S. M. Tawfik, A. Saleh, A. Elbeih, T. M. Klapötke, Z. Anorg. Allg. Chem., 2016, 642, 1222 - 1229. Synthesis and characterization of energetic cesium 5-methyl-2,4,6-trinitrobenzene-1,3-diolate, A. Drechsel, T. M. Klapötke, T. G. Witkowski, Jacobs Journal of Inor-ganic Chemistry, J J Inorg Chem. 2016, 1(1):001 - 008. N-Nitrosarcosine: An Economic Precursor for the Synthesis of New Energetic Ma-terials, T. M. Klapötke, B. Krumm, R. Scharf, Chemistry – Asian J, 2016, 11, 3134 - 3144.

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Investigation on the Sodium and Potassium Tetrasalts of 1,1,2,2-Tetranitraminoethane, M. Born, Martin A. C. Härtel, T. M. Klapötke, M. Mallmann, Jörg Stierstorfer, Z. Anorg. Allg. Chem. 2016, 642(24), 1412 - 1418. Synthesis and Investigation of Advanced Energetic Materials Based on Bispyrazol-ylmethanes, D. Fischer, J. L. Gottfried, T. M. Klapötke, K. Karaghiosoff, J. Stier-storfer, T. G. Witkowski, Angew Chem. Int. Ed., 2016, 55, 16132 –16135. Convenient Synthesis of Energetic Polynitro Materials including (NO2)3CCH2CH2NH3-Salts via Michael Addition of Trinitromethane, Q. Axtham-mer, T. M. Klapötke, B. Krumm, R. Scharf, C. Unger, Dalton Trans. 2016, 45, 18909–18920. A New Energetic Binder: Glycidyl Nitramine Polymer, F. M. BETZLER, V. A. HARTDEGEN, T. M. KLAPÖTKE, S. M. SPROLL, Central Europ. J Energ. Mat. 2016, 13(2) 289 – 300. Benchmark properties of 2-, 3-and 4-nitrotoluene: evaluation of the thermochemi-cal data with Greta Bikelytė; Martin Härtel; Jörg Stierstorfer; Thomas M Klapötke, , Andrey A Pimerzin, Sergey P. Verevkin, The Journal of Chemical Thermodynam-ics J. Chem. Thermodynamics 111 (2017) 271–278. Application of Headspace and Direct Immersion Solid-Phase Microextraction (SPME) in the Analysis of Organothiophosphates related to the Chemical Weapons Convention (CWC) from Water and Complex Matrices, M. Althoff, A.Bertsch; M. Metzulat, T. M Klapötke, K. L Karaghiosoff, Talanta 174 (2017) 295–300 Synthesis, Solvatochromism, Antibacterial Activity and Dyeing Performance of Tricyanofuran-Hydrazone Analogues, T. A. Khattab, H. E. Gaffer, S. Abdelmoez Aly, T. M. Klapötke, Chemistry Select 2016, 1, 6805 – 6809.. M42 Primer Processing with Potassium and Copper Salt Formulations, M. M. Puszynski, N. Mehta, G. Cheng, K. D. Oyler, D. Fischer, T. M. Klapötke, J. Stier-storfer; J J Inorg Chem. 2016, 1(1): 003. Two text books Energetic Compounds, M. H. Kashavarz, T. M. Klapötke, De Gruyter, Berlin, Bos-ton, 2017. Chemistry of High Energy Materials, 4th edn., T. M. Klapötke, Walter de Gruyter, Berlin/Boston, 2017.

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Inorganic Chemistry Prof. Dr. rer. nat. Peter Klüfers Born 1951 in Uerdingen, 1969–1974 study of chemistry at Cologne University, 1978 PhD degree in the group of Prof. Dr. H.-U. Schuster, Cologne University, 1981–1983 study of pharmacy, Bonn University, 1983 habilitation under the su-pervision of Prof. Dr. H.-U. Schuster, Cologne University, 1983–1986, research assistant, Institute of Inorganic Chemistry, Cologne University, 1986–1987 em-ployed by Enka-AG (now AkzoNobel), 1988–1989 professor of inorganic chemis-try, Karlsruhe University, 1999-present professor and chair of bioinorganic chemis-try and coordination chemistry, Ludwig-Maximilians-Universität München Research Topics Coordination chemistry, bioinorganic chemistry, structure determination, supramo-lecular chemistry, carbohydrate-metal complexes, nitrosyl complexes Honors, Awards, Memberships Vice-chairman, Konferenz der Fachbereiche Chemie (KFC) Member of the Editorial Board, ZAAC Publications – Scientific Papers M. Wolf, P. Klüfers: Structure and Bonding of High-Spin Nitrosyl–Iron(II) Com-pounds with Mixed N,O-Chelators and Aqua Ligands. Eur. J. Inorg. Chem. 2017, 2303–2312. M. Wolf, B. M. Aas, P. Klüfers: High-Spin Nitrosyl–Iron(II) Compounds. Eur. J. Inorg. Chem. 2017, 2302–2302. D. Merker, L. Böhm, M. Oßberger, P. Klüfers, M. Kraume: Mass Transfer in Reac-tive Bubbly Flows – A Single-Bubble Study. Chemical Engineering & Technology 2017, 40, 1391-1399. D. Beck, A. Belz, A. In-Iam, P. Mayer, P. Klüfers: NO(HSO4), a Fairly Ionic Solid. Z. Anorg. Allg. Chem. 2017, 643, 1191–1194.

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B. M. Aas, P. Klüfers: The Structural Chemistry of Stable High-Spin Nitrosyl–Iron(II) Compounds with Aminecarboxylato Co-Ligands in Aqueous Solution. Eur. J. Inorg. Chem. 2017, 2313–2320. T. G. Hörner, P. Klüfers: The Species of Fehling's Solution. Eur. J. Inorg. Chem. 2016, 1798–1807. N. Casaretto, B. Fournier, S. Pillet, E. E. Bendeif, D. Schaniel, A. K. E. Gallien, P. Klufers, T. Woike: Photo-induced linkage NO isomers in the dinitrosyl complex [Ru(NO)2(PCy3)2Cl](BF4) identified by photocrystallography and IR-spectroscopy. CrystEngComm 2016, 18, 7260–7268. Publications by other group members Crystal structure, microbiological activity and theoretical studies of Ag(I) and Cu(I) coordination polymers with 1,1’-(butane-1,4-diyl)bis(3-methylimidazoline-2-thione) ligand. A. Behesti, S. S. Babadi, K. Nozarian, F. Heidarizadeh, N. Ghamari, P. Mayer, H. Motamedi, Polyhedron 2016, 110, 261-273. Crystal structure of 2-[chloro(4-methoxyphenyl)methyl]-2-(4-methoxyphenyl)-5,5-dimethylcyclohexane-1,3-dione. S. Chelli, K. Troshin, S. Lakhdar, H. Mayr, P. Mayer, Acta Cryst. 2016, E72, 300-303. Polyfunctional Lithium, Magnesium and Zinc Alkenyl Reagents as Building Blocks for the Synthesis of Complex Heterocycles. Z.-L. Shen, V. Dhayalan, A. D. Be-nischke, R. Greiner, K.Karaghiosoff, P. Mayer, P. Knochel. Angew. Chem. Int. Ed. Engl. 2016, 55, 5332-5336. 6-[6-(Pyridin-2-yl)-1,2,4,5-tetrazin-3-yl]pyridin-3-amine monohydrate. J. Broich-hagen, Y. E. Klingl, D. Trauner, P. Mayer, Acta Cryst. 2016, E72, 238-240. Crystal structure of (1S,2R)-6,6-dimethyl-4,8-dioxo-2-phenylspiro[2.5]octane-1-carbaldehyde. S. Chelli, K. Troshin, S. Lakhdar, H. Mayr, P. Mayer, Acta Cryst. 2016, E72, 266-268. A high-yielding, strictly regioselective prebiotic purine nucleoside formation path-way. S. Becker, I. Thoma, A. Deutsch, T. Gehrke, P. Mayer, H. Zipse, T. Carell, Science 2016, 352, 833-836. Ethenesulfonyl Fluoride: The Most Perfect Michael Acceptor Ever Found? Q. Chen, P. Mayer, H. Mayr, Angew. Chem. Int. Ed. 2016, 55, 12664-12667.

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Stereoselective Synthesis and Retentive Trapping of α-Chiral Secondary Alkyllith-iums Leading to Stereodefined α,β-Dimethyl Carboxylic Esters. V. Morozova, K. Moriya, P. Mayer, P. Knochel, Chem. Eur. J. 2016, 22, 9962-9965. Synthesis, structural characterization, antibacterial activity and computational stud-ies of new cobalt(II) complexes with 1,1,3,3,-tetrakis(3,5-dimethyl-1-pyrazolyl)propane ligand. A. Beheshti, F. Safaeiyan, F. Hashemi, H. Motamedi, P. Mayer, G. Bruno, H. A. Rudbari, J. Mol. Struct. 2016, 1123, 225-237. Nucleophilicity Parameters of Stabilized Iodonium Ylides for Characterizing Their Synthetic Potential. S. Chelli, K. Troshin, P. Mayer, S. Lakhdar, A. R. Ofial, H. Mayr, J. Am. Chem. Soc. 2016, 138, 10304-10313. Lewis Acidities of Indol-3-ylmethylium Ions and Intrinsic Barriers of Their Reac-tions with Phosphines and Pyridines. E. Follet, P. Mayer, H. Mayr, Eur. J. Org. Chem. 2016, 2016, 4050-4058. Synthesis and characterization of the porous zinc phosphonate [Zn2(H2PPB)(H2O)2] · x H2O. N. Hermer, H. Reinsch, P. Mayer, N. Stock, CrystEngComm 2016, 18, 8147-8150. Toward Fluorinated Spacers for MAPI-Derived Hybrid Perovskites: Synthesis, Characterization, and Phase Transitions of (FC2H4NH3)2PbCl4. C. Lermer, S. T. Birkhold, I. L. Moudrakovski, P. Mayer, L. M. Schoop, L. Schmidt-Mende, B. V. Lotsch, Chem. Mater. 2016, 28, 6560-6566. Twisted Hemithioindigo Photoswitches: Solvent Polarity Determines the Type of Light-Induced Rotations. S. Wiedbrauk, B. März, E. Samoylova, A. Reiner, F. Trommer, P. Mayer, W. Zinth, H. Dube, J. Am. Chem. Soc. 2016, 138, 12219-12227. Photocontrol of Polar Aromatic Interactions by a Bis-Hemithioindigo Based Heli-cal Receptor. M. Guentner, E. Uhl, P. Mayer, H. Dube, Chem. Eur. J. 2016, 22, 16433-16436. Spectroscopic and cytotoxic characteristics of (p-cymene)Ru(II) complexes with bidentate coumarins and density functional theory comparison with selected (Pd(II) complexes. A. Skoczynska, K. Lux, P. Mayer, I.-P. Lorenz, U. Krajewska, M. Roz-alski, A. Dolega, E. Budzisz, Inorg. Chim. Acta 2016, 456, 105-112. Dimensionality on the Band Gap. C. Lermer, S. P. Harm, S. T. Birkhold, J. A. Jaser, C. M. Kutz, P. Mayer, L. Schmidt-Mende, B. V. Lotsch, Z. Anorg. Allg.

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Chem. 2016, 642, 1369-1376. Synthesis, characterization, EPR spectroscopy and catalytic activity of a new oxi-dovanadium(IV) complex with N2O2-donor ligand. P. Mahboubi-Anarjan, R. Bikas, H. Hossieni-Monfared, P. Aleshkevych, P. Mayer, J. Mol. Struct. 2017, 1131, 258-265. Structures, Lewis Acidities, Electrophilicities and Protecting Group Abilities of Phenylfluorenylium and Tritylium Ions. E. Follet, P. Mayer, G. Berionni, Chem. Eur. J. 2017, 23, 623-630. Nucleophilicity Parameters of Arylsulfonyl-Substituted Halomethyl Anions. Z. Li, Q. Chen, P. Mayer, H. Mayr, J. Org. Chem. 2017, 82, 2011-2017. Structural variability in Cu(I) and Ag(I) coordination polymers with a flexible di-thione ligand: Synthesis, crystal structure, microbiological and theoretical studies. A. Beheshti, K. Nozarian, S. S. Babadi, S. Noorizadeh, H. Motamedi, P. Mayer, G. Bruno, H. A. Rudbari, J. Solid State Chem. 2017, 249, 70-79. Ingredients to TICT Formation in Donor Substituted Hemithioindigo. S. Wied-brauk, B. März, E. Samoylova, P. Mayer, W. Zinth, H. Dube, J. Phys. Chem. Lett. 2017, 8, 1585-1592. Bistable Photoswithing of Hemithioindigo with Green and Red Light: Entry Point to Advanced Molecular Digital Information Processing. F. Kink, M. P. Collado, S. Wiedbrauk, P. Mayer, H. Dube, Chem. Eur. J. 2017, 23, 6237-6243. New 2D hybrid perovskite systems for optoelectronic applications. C. Lermer, S. T. Birkhold, S. P. Harm, I. L. Moudrakovski, L. M. Schoop, P. Mayer, L. Schmidt-Mende, B. V. Lotsch, Abstracts of Papers, 253rd ACS National Meeting & Exposi-tion, San Francisco, CA, United States, April 2-6, 2017, INOR-787. Reactivity-Tuning in Frustrated Lewis Pairs: Nucleophilicity and Lewis Basicity of Sterically Hindered Phosphines. E. Follet, P. Mayer, D. S. Stephenson, A. R. Ofial, G. Berionni, Chem. Eur. J. 2017, 23, 7422-7427. Uncatalyzed C-H Amination of Aromatic Compounds under Unusually Mild Con-ditions with Negative Enthalpies of Activation. H. Langhals, M. Eberspächer, P. Mayer, Asian J. Org. Chem. 2017, 6, 1080-1085. Frontispiece: Bistable Photoswitching of Hemithioindigo with Green and Red Light: Entry Point to Advanced Molecular Digital Information Processing. F. Kink,

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M. P. Collado, S. Wiedbrauk, P. Mayer, H. Dube, Chem. Eur. J. 2017, 23, n/a. Synthesis, structural characterization, DFT studies and catalytic properties of dinu-clear oxidovanadium(V) complexes derived from adipohydrazone ligands. H. Noei-Hootkani, S. Karrari, H. Hosseini-Monfared, P. Mayer, B. Notash, J. Mol. Struct. 2017, 1143, 452-461. Synthesis of a new Hg(II) coordination polymer: Ultrasonic-assisted synthesis and mechanical preparation of nanostructure. F. Bigdeli, H. Hosseini-Monfared, A. Morsali, P. Mayer, Ultrasonics Sonochemistry 2017, 39, 669-675. Synthesis, structural characterization, QSAR and docking studies of a new binucle-ar nickel(II) complex based on the flexible tetradentate N-donor ligand as a potent antibacterial and anticancer agent. A. Beheshti, F. Hashemi, F. Behavndi, M. Zahe-di, M. Kolahi, H. Motamedi, P. Mayer, Int. J. Biol. Macromol. 2017, 104, 1107-1123. Design, Synthesis, and Antibacterial Assessment of Silver(I)-Based Coordination Polymers with Variable Counterions and Unprecedented Structures by the Tuning Spacer Length and Binding Mode of Flexible Bis(imidazole-2-thiones) Ligands. A. Beheshti, S. Seleymani-Babadi, P. Mayer, C. T. Abrahams, H. Motamedi, D. Trzybinski, K. Wozniak, Cryst. Growth Des. 2017, 17, 5249-5262. NO(HSO4), a Fairly Ionic Solid. D. Beck, A. Belz, A. In-Iam, P. Mayer, P. Klüfers, Z. Anorg. Allg. Chem. 2017, 643, 1191-1194. Solvation Accounts for the Counterintuitive Nucleophilicity Ordering of Peroxide Anions. R. J. Mayer, T. Tokuyasu, P. Mayer, J. Gomar, S. Sabelle, B. Mennucci, H. Mayr, A. R. Ofial, Angew. Chem. Int. Ed. 2017, 56, 13279-13282. Hemiindigo: Highly Bistable Photoswitching at the Biooptical Window. C. Peter-mayer, S. Thumser, F. Kink, P. Mayer, H. Dube, J. Am. Chem. Soc. 2017, 139, 15060-15067. Synthesis and crystal structure of a homoleptic diruthenium complex containing tetra-2-pyridyl-1,4-pyrazine (tppz). M. Graf, P. Mayer, H.-C. Böttcher, Z. Natur-forsch. B 2017, 72, 759-762. Direct Observation of Hemithioindigo-Motor Unidirectionality. L. A. Huber, K. Hoffmann, S. Thumser, N. Böcher, P. Mayer, H. Dube, Angew. Chem. Int. Ed. 2017, 56, 14536-14539.

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Inorganic Chemistry Prof. Dr. rer. nat. Andreas Kornath Born 1965 in Hohenstein/Danzig, 1985 – 1990 study of chemistry at Univ. Dort-mund, 1993 PhD degree in the group of Prof. Dr. Rolf Minkwitz at Univ. Dort-mund, 1994 Postdoctoral fellow in the group of Prof. Dr. Joseph Thrasher at Uni-versity of Alabama, Tuscaloosa, 1999 Research visitor in the group of Prof. Dr. Karltto at USC, Los Angeles, 2000 habilitation at the Univ. Dortmund, 2000-2005 lecturer at the Univ. Dortmund, 2005 substitute professor at Univ. Rostock, 2005-2006 substitute professor at LMU, since 2007 W2-professor at LMU. Research Topics Synthesis and characterization of protonated species in superacidic media. Devel-opment of fluorinating and fluoromethylating agents. Matrix isolation spectroscopy of highly reactive molecules and metal clusters Honors, Awards, Memberships Member of the Gesellschaft Deutscher Chemiker Extramural Research Funding Collaborative Research with ABCR Dr. Braunagel GmbH “Gas Filling methods” Collaborative Research with F-Select GmbH “Fluoromethylating agents” Publications – Scientific Papers N. R. Götz, J. A. H. Axhausen, T. Soltner, C. Rotter, A. Kornath, Protonated Hy-drogen Cyanide, ChemistrySelect 2016, 5517-5520. R. Haiges, A. F. Baxter, N. R. Goetz, J. A. Axhausen, T. Soltner, A. Kornath, K. O. Christe, Protonation of nitriles: isolation and characterization of alkyl- and arylni-trilium ions, Dalton Trans. 2016, 45, 8494-8499.

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M. Schickinger, Y. Morgenstern, K. Stierstorfer, A. Kornath, Protonation of malo-nonitrile in superacidic solutions, Z. Anorg. Allg. Chem. 2017, 643, 1431-1435. D. Leitz, M. Hopfinger, K. Stierstorfer, Y. Morgenstern, J. Axhausen, A. Kornath, Methanesulfonamide in Superacids: Investigations of the CH3SO2NH3 Cation, Z. Anorg. Allg. Chem. 2017, 643, 1202-1207. S. I. Ivlev, T. Soltner, A. J. Karttunen, M. Muehlbauer, A. Kornath, F. Kraus, Syn-theses and Crystal Structures of Sodium Hydrogen Fluorides NaF·nHF (n = 2, 3, 4), Z. Anorg. Allg. Chem. 2017, 643, 1436-1443. Other Activities Managing director of the company F-Select GmbH.

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Inorganic Chemistry Univ.-Prof. Dr. rer. nat. Bettina Valeska Lotsch Born 1977 in Frankenthal/Pfalz, 1997-2002 study of chemistry at LMU Munich and University of Oxford, 2006 PhD degree in the group of Prof. Dr. Wolfgang Schnick, LMU Munich, 2007-2008 Postdoctoral fellow in the group of Prof. Dr. Geoffrey Ozin, University of Toronto, Canada, since 2009 W2 tenure track profes-sor LMU Munich (tenure 2014) and independent group leader at the Max Planck Institute for Solid State Research, Stuttgart (2011-2017), since 2017 Director of the Nanochemistry Department at the Max Planck Institute for Solid State Research, Stuttgart and Honorary Professor at LMU Munich. Research Topics Rational design of functional materials at the intersection between solid-state and nanochemistry: Functional frameworks, 2D nanosheet materials and artificial het-erostructures, photonic nanostructures for optical sensing, new concepts for energy conversion and storage with a special focus on artificial photosynthesis and high performance solid electrolytes for battery applications. Honors, Awards, Memberships EU-40 Materials Prize, European Materials Research Society Member of the Scientific Advisory Board of the EPSRC Doctoral Training Center in Nanoscience and Nanotechnology (NanoDTC), University of Cambridge Member of the Scientific Selection Board of the Alexander von Humboldt Founda-tion (Feodor-Lynen Board) Advisory Board Member, Zeitschrift für Anorganische und Allgemeine Chemie (Wiley) Advisory Board Member, Chemistry of Materials (ACS) Member of the Advisory Board Journal of Materials Chemistry A (RSC) Member of the Editorial Board Annual Review of Materials Research Member of the Gesellschaft Deutscher Chemiker (GDCh) Member of the Deutsche Gesellschaft für Kristallographie (DGK) Principal Investigator of the cluster of excellence Nanosystems Initiative Munich (NIM) Principal Investigator of the Max Planck – EPFL Center for Molecular Nano-science and Technology

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Principal Investigator of the International Max Planck Research School ”Con-densed Matter Science“ Extramural Research Funding DFG SPP-1928 COORNETs, “Photoelectrocatalysis with Porous Coordination Polymers – Architectural Design, Morphology Control and Transport Properties”, 2016 - 2019 ERC Starting Grant “COFLeaf”, 2014 - 2019 Bundesministerium für Bildung und Forschung (BMBF), “Stickstoffhaltige Koh-lenstoffe für hochkapazitive zyklenstabile Lithium-Schwefel-Kathoden“, 2015 - 2018 Max Planck-EPFL Center for Molecular Nanoscience and Technology, “Photoelec-troechemical Water splitting by GsAs Nanowire Arrays on Si” Max Planck-EPFL Center for Molecular Naoscience and Technology, 2014 -2017 “Novel materials for Li-ion batteries: A combined experimental and theoretical ap-proach, and the challenge of mixed-valence transition-metal oxides”, 2014 -2017 Excellence Cluster Nanosystems Initiative Munich, NIM (DFG and the Federal Ministry of Education and Research), 2010 - 2018 Publications – Scientific Papers C.P. Weber, B.S. Berggren, M.G. Masten, T.C. Ogloza, S. Deckoff-Jones, J. Madéo, M.K.L. Man, K.M. Dani, L. Zhao, G. Chen, J. Liu, Z. Mao, L.M. Schoop, B.V. Lotsch, S.S.P. Parkin, M. Ali, Similar ultrafast dynamics of several dissimilar Dirac and Weyl semimetals, J. Appl. Phys. 2017, 122, 223102. A. Topp, R. Queiroz, A. Grüneis, L. Müchler, A. Rost, A. Varykhalov, D. Marchenko, M. Krivenkov, F. Rodolakis, J.L. McChesney, B.V. Lotsch, L.M. Schoop, C.R. Ast, Surface floating 2D bands in layered nonsymmorphic semimet-als: ZrSiS and related compounds, Phys. Rev. X 2017, arXiv: 1709.00319. M.B. Schilling, L.M. Schoop, B.V. Lotsch, M. Dressel, A.V. Pronin, Flat optical conductivity in ZrSiS due to two-dimensional Dirac bands, Phys. Rev. Lett. 2017, 119, 187401. C. Ziegler, T.K. Dennenwaldt, D. Weber, V. Duppel, C. Kamella, F. Podjaski, B. Tuffy, I. Moudrakovski, C. Scheu, B.V. Lotsch, Functional engineering of per-ovskite nanosheets: Impact of lead substitution on exfoliation in the solid solution RbCa2-xPbxNb3O10, Z. Anorg. Allg. Chem 2017, 643, 1668–1680.

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T. Banerjee, F. Haase, G. Savasci, K. Gottschling, C. Ochsenfeld, B.V. Lotsch, Single site photocatalytic H2 evolution from Covalent Organic Frameworks with molecular cobaloxime co-catalysts, J. Am. Chem. Soc. 2017, 139, 16228–16234. L.M. Schoop, R. Eger, J. Nuss, F. Pielnhofer, B.V. Lotsch, The First Quinary Rare Earth Thiophosphates: Cs5Ln3X3(P2S6)2(PS4) (Ln = La, Ce, X = Br, Cl) and the Quasi-Quaternary Cs10Y4Cl10(P2S6)3 Z. Anorg. Allg. Chem. 2017, 643, 1818–1823. K. Szendrei, A. Jiménez-Solano, G. Lozano, B.V. Lotsch, H. Míguez, Fluorescent humidity sensors based on photonic resonators, Adv. Opt. Mater. 2017, 5, 1700663. B.V. Lotsch, J. Maier, Relevance of solid electrolytes for Li-based batteries: A real-istic view, J. Electroceram. 2017, 38, 128–141. D. Weber, L. Schoop, D. Wurmbrand, J. Nuss, E. Seibel, F. Tafti, H. Ji, R. Cava, R. Dinnebier, B.V. Lotsch, Trivalent iridium oxides: Layered triangular lattice iridate K0.75Na0.25IrO2 and oxyhydroxide IrOOH, Chem. Mater. 2017, 29, 8338–8345. F. Haase, T. Banerjee, G. Savasci, C. Ochsenfeld, B.V. Lotsch, Structure-property-activity relationships in a pyridine containing azine-linked covalent organic frame-work for photocatalytic hydrogen evolution, Faraday Discuss. 2017, 201, 247–264. D. Fischer, A. von Mankowski, A. Ranft, S. Vasa, R. Linser, J. Mannhart, B.V. Lotsch, ZIF-8 films prepared by femtosecond pulsed-laser-deposition, Chem. Ma-ter. 2017, 29, 5148–5155. P. Ganter, B.V. Lotsch, Photocatalytic nanosheet lithography: Photolitho-graphy based on organically modified photoactive 2D nanosheets, Angew. Chem. Int. Ed. 2017, 56, 8389–8392. T. Botari, W.P. Huhn, V.W.-h. Lau, B.V. Lotsch, V. Blum, Thermodynamic equi-libria in carbon nitride photocatalyst materials and conditions for the existence of graphitic carbon nitride g-C3N4, Chem. Mater. 2017, 29, 4445–4453. P. Ganter, C. Ziegler, A.T. Friedrichs, V. Duppel, C. Scheu, B.V. Lotsch, A new fabrication method for single-layer nanosheets by silver-assisted exfoliation, ChemNanoMat 2017, 3, 411–414. F. Haase, K. Gottschling, L. Stegbauer, L.S. Germann, R. Gutzler, V. Duppel, V.S. Vyas, K. Kern, R.E. Dinnebier, B.V. Lotsch, Tuning the stacking behaviour of a 2D covalent organic framework through non-covalent interactions, Mater. Chem.

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Front. 2017, 1, 1354−1361. A.U. Meyer, V.W.-h. Lau, B. König, B.V. Lotsch, Photocatalytic oxidation of sul-finates to vinyl sulfones with cyanamide-functionalised carbon nitride, Eur. J. Org. Chem. 2017, 3, 2179–2185. L. Schoop, R. Eger, R. Kremer, A. Kuhn, J. Nuss, B.V. Lotsch, Structural stability diagram of ALnP2S6 compounds (A = Na, K, Rb, Cs; Ln = lanthanide), Inorg. Chem. 2017, 56, 1121–1131. V.W.-h. Lau, V.W.-z. Yu, F. Ehrat, T. Botari, I. Moudrakovski, T. Simon, V. Dup-pel, E. Medina, J. Stolarczyk, J. Feldmann, V. Blum, B.V. Lotsch, Urea-modified carbon nitrides: Enhancing photocatalytic hydrogen evolution by rational defect engineering, Adv. Energy Mater. 2017, 7, 1602251. P. Ganter, L. Schoop, B.V. Lotsch, Towards tunable photonic nanosheet sensors: Strong influence of the interlayer cation on the sensing characteristics, Adv. Mater. 2017, 29, 1604884. V.W.-h. Lau, D. Klose, H. Kasap, F. Podjaski, M.-C. Pignié, E. Reisner, G. Jesch-ke, B.V. Lotsch, Dark photocatalysis: Storage of solar energy in carbon nitride for time-delayed hydrogen generation, Angew. Chem. Int. Ed. 2017, 56, 510–514. A. Topp, J.M. Lippmann, A. Varykhalov, V. Duppel, B.V. Lotsch, C.R. Ast, L.M. Schoop, Non-symmorphic band degeneracy at the Fermi level in ZrSiTe, New J. Phys. 2016, 18, 125014. M.N. Ali, L.M. Schoop, C. Garg, J.M. Lippmann, E. Lara, B.V. Lotsch, S. Parkin, Butterfly magnetoresistance, quasi-2D dirac fermi surfaces, and a topological phase transition in ZrSiS, Sci. Adv. 2016, 2, e1601742. C. Lermer, S.P. Harm, S.T. Birkhold, J.A. Jaser, C.M. Kutz, P. Mayer, L. Schmidt-Mende, B.V. Lotsch, Benzimidazolium lead halide perovskites: Effects of anion substitution and dimensionality on the band gap, Z. Anorg. Allg. Chem. 2016, 642, 1369–1376. J. Na, A. Hoyer, L. Schoop, D. Weber, B.V. Lotsch, M. Burghard, K. Kern, Tuning the magnetoresistance of ultrathin WTe2 sheets by electrostatic gating, Nanoscale 2016, 8, 18703-18709. S. Betzler, F. Podjaski, M. Beetz, K. Handloser, A. Wisnet, M. Handloser, A. Hartschuh, B.V. Lotsch, C. Scheu, Titanium doping and its effect on the morpholo-

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gy of three-dimensional hierarchical Nb3O7(OH) nanostructures for enhanced light-induced water splitting, Chem. Mater. 2016, 28, 7666–7672. C. Lermer, S. Birkhold, I. Moudrakovski, P. Mayer, L. Schoop, L. Schmidt-Mende, B.V. Lotsch, Towards fluorinated spacers for MAPI-derived hybrid perovskites: Synthesis, characterization, and phase transitions of (FC2H4NH3)2PbCl4, Chem. Ma-ter. 2016, 28, 6560–6566. V. Vyas, M. Vishwakarma, I. Moudrakovski, F. Haase, G. Savasci, C. Ochsenfeld, J.P. Spatz, B.V. Lotsch, Exploiting non-covalent interactions in an imine-based co-valent organic framework for quercetin delivery, Adv. Mater. 2016, 28, 8749–8754. P. Ganter, K. Szendrei, B.V. Lotsch, Towards the nanosheet-based photonic nose: Vapor recognition and trace water sensing with antimony phosphate thin film de-vices, Adv. Mater. 2016, 28, 7436–7442. V. Vyas, V.W.-h. Lau, B.V. Lotsch, Soft photocatalysis: Organic polymers for so-lar fuel production, Chem. Mater. 2016, 28, 5191–5204. A. Kuhn, L. Schoop, R. Eger, I. Moudrakovski, S. Schwarzmüller, V. Duppel, R. Kremer, O. Oeckler, B.V. Lotsch, The copper selenido-phosphates Cu4P2Se6, Cu4P3Se4, Cu4P4Se3, and CuP2Se, featuring novel 0-, 1-, and 2-dimensional anions, Inorg. Chem. 2016, 55, 8031–8040. T. Holzmann, L. Schoop, M.N. Ali, I. Moudrakovski, G. Gregori, J. Maier, R.J. Cava, B.V. Lotsch, Li0.6[Li0.2Sn0.8S2] – A layered lithium superionic conductor, En-ergy Environ. Sci. 2016, 9, 2578–2585. H. Kasap, C. Caputo, B. Martindale, R. Godin, V.W.-h. Lau, B.V. Lotsch, J. Dur-rant, E. Reisner, Solar-driven reduction of aqueous protons coupled to selective al-cohol oxidation with a carbon nitride - molecular Ni catalyst system, J. Am. Chem. Soc. 2016, 138, 9183–9192. K. Szendrei, P. Ganter, B.V. Lotsch, Selectivity, cycling stability and tempe-rature dependence of touchless finger motion tracking devices based on 1D photonic crys-tal, Proc. SPIE 9885, 2016, Photonic Crystal Materials and Devices XII, 98850Z. V.W.-h. Lau, I. Moudrakovski, T. Botari, S. Weinberger, M.B. Mesch, V. Dup-pel, J. Senker, V. Blum, B.V. Lotsch, Rational design of carbon nitride photocata-lysts by identification of cyanamide defects as catalytically relevant sites, Nat. Commun. 2016, 7, 12165.

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L.M. Schoop, M.N. Ali, C. Strasser, A. Topp, A. Varykhalov, D. Marchenko, V. Duppel, S.S.P. Parkin, B.V. Lotsch, C.R. Ast, Dirac cone protected by non-symmorphic symmetry and 3D dirac line node in ZrSiS, , Nat. Commun. 2016, 7, 11696. K. Virdi, Y. Kauffmann, C. Ziegler, P. Ganter, P. Blaha, B.V. Lotsch, W.D. Kaplan, C. Scheu, Band gap extraction from individual two-dimensional perovskite nanosheets using valence electron energy loss spectroscopy, J. Phys. Chem. C 2016, 120, 11170–11179. D. Weber, L.M. Schoop, V. Duppel, J.M. Lippmann, J. Nuss, B.V. Lotsch, Magnet-ic properties of restacked 2D spin 1 2 honeycomb RuCl3 nanosheets, Nano Letters 2016, 16, 3578–3584. A. Kuhn, L.M. Schoop, R. Eger, B.V. Lotsch, Synthesis and characterization of copper hexathiometadiphosphate Cu2P2S6, Z. Anorg. Allg. Chem. 2016, 642, 356–360. S. Krotzky, C. Morchutt, V.S. Vyas, B.V. Lotsch, R. Gutzler, K. Kern, Thermody-namics of the segregation of a kinetically trapped two-dimensional amorphous met-al−organic network, J. Phys. Chem. C 2016, 120, 4403–4409. E. Flügel, V.W-H. Lau, H. Schlomberg, R. Glaum, B.V. Lotsch, Homonuclear mixed-valent cobalt imidazolate framework for oxygen-evolution electrocatalysis, Chem. Eur. J. 2016, 22, 3676–3680. Other Activities Max Planck – EPFL Center for Molecular Nanoscience and Technology Summer School, Berlin, June 11 – 15, 2016; Mentoring (ProProfessur, Land Hessen; TANDEM, RWTH Aachen), Member of the Steering Committee of SPP-1928, Grant reviewer for European Research Council, Deutsche Forschungsgemeinschaft, Alexander von Humboldt-foundation, Reaxys PhD Prize, Studienstiftung des Deutschen Volkes; Reviewer for Advanced Materials, Angewandte Chemie, Chem-ical Communications, Chemistry – A European Journal, Chemistry of Materials, ACS Applied Materials & Interfaces, CrystEngComm, Inorganic Chemistry, Jour-nal of Materials Chemistry A, Journal of the American Chemical Society, Mi-croporous & Mesoporous Materials, Nanoscale, Nano Letters, Nature Communica-tions, Scientific Reports, Sensors, Small, Solid State Sciences, Solid State Ionics, The Journal of Physical Chemistry, The Journal of Physical Chemistry Letters, Zeitschrift für Anorganische und Allgemeine Chemie.

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Inorganic Chemistry Univ.-Prof. Dr. rer. nat. Wolfgang Schnick Born 1957 in Hannover; 1983 Diploma in chemistry, University of Hannover; 1986 Dr. rer. nat., inorganic chemistry, University of Hannover; 1992 habilitation in in-organic chemistry, University of Bonn; 1986 - 87 scientific assistant (C1), Univer-sity of Hannover; 1987 - 88 guest scientist, Max-Planck Institute for Solid-State Research MPI-FKF, Stuttgart; 1988 - 93 scientific assistant (C1), University of Bonn; 1992 offer C4-professor (chair) for inorganic and general chemistry, Hum-boldt University Berlin, declined; 1993 - 98 C4-professor (chair) for inorganic chemistry, University of Bayreuth; 1998 - 2006 C4-professor (chair) for inorganic solid-state chemistry, University of Munich (LMU); 2005 offer scientific member of the Max-Planck Society and director at the Max-Planck Institute for Metals Re-search MPI-MF, Stuttgart, declined; 2005 offer W3-professor (chair) for fundamen-tals of ceramic materials, University of Stuttgart, declined; since 2006 W3-professor (chair) for inorganic solid-state chemistry, University of Munich (LMU). Research Topics Inorganic solid-state and materials chemistry; discovery, development and applica-tion of novel functional materials based on nitrides and oxonitrides of group 13 – 15 elements in combination with alkali, alkaline earth, rare earth metals or hydro-gen. Nitridosilicates, nitridophosphates, nitridoaluminates, nitridogallates, nitridic zeolites, C3N4-precursor compounds. A major application breakthrough has been achieved by the discovery and development of highly efficient Eu2+-doped nitride luminescent materials that are now being industrially used for phosphor converted (pc)-LEDs. Extramural Research Funding Deutsche Forschungsgemeinschaft DFG (German Research Foundation); Fonds der Chemischen Industrie FCI (German Chemical Industry Fund); Publications – Scientific Papers Highly Symmetric AB2 Framework Related to Tridymite in the Disordered Nitrido-silicate La24Sr14-7x[Si36N72](O1-xFx)14 (x = 0.486); L. Neudert, D. Durach, F. Fahrn-bauer, G.B.M. Vaughan, W. Schnick, O. Oeckler; Inorg. Chem. 2017, 56, 13070

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Ammonothermal Synthesis of Alkali-Alkaline Earth Metal and Alkali-Rare Earth Metal Carbodiimides: K5−xMx(CN2)2+x(HCN2)1−x (M = Sr, Eu) and Na4.32Sr0.68(CN2)2.68(HCN2)0.32; M. Mallmann, J. Häusler, N. Cordes, W. Schnick; Z. Anorg. Allg. Chem. 2017, 643, 1956 Efficient Yellow-orange Phosphor Lu4Ba2[Si9ON16]O:Eu2+ and Orange-red Emit-ting Y4Ba2[Si9ON16]O:Eu2+: Two Oxonitridosilicate Oxides with Outstanding Structural Variety; C. Maak, R. Niklaus, F. Friedrich, A. Mähringer, P.J. Schmidt, W. Schnick; Chem. Mater. 2017, 29, 8377 Direct Measurements of Energy Levels and Correlation with Thermal Quenching Behaviour in Nitride Phosphors; T.M. Tolhurst, P. Strobel, P.J. Schmidt, W. Schnick, A. Moewes; Chem. Mater. 2017, 29, 7976 Puzzling Intergrowth in Cerium Nitridophosphate Unraveled by Joint Venture of Aberration-Corrected Scanning Transmission Electron Microscopy and Synchro-tron Diffraction; S.D. Kloß, L. Neudert, M. Döblinger, M. Nentwig, O. Oeckler, W. Schnick; J. Am. Chem. Soc. 2017, 139, 12724 Ammonothermal Synthesis of Crystalline Oxonitride Perovskites LnTaON2 (Ln = La, Ce, Pr, Nd, Sm, Gd); N. Cordes, W. Schnick; Chem. Eur. J. 2017, 23, 11410 Designing Luminescent Materials and Band Gaps: A Soft X-ray Spectroscopy and Density Functional Theory Study of Li2Ca2[Mg2Si2N6]:Eu2+ and Ba[Li2(Al2Si2)N6]:Eu2+; T.M. Tolhurst, P. Strobel, P.J. Schmidt, W. Schnick, A. Moewes; J. Phys. Chem. C. 2017, 121, 14296 Functional Carbon Nitride Materials – Design Strategies for Electrochemical De-vices; F.K. Kessler, Y. Zheng, D. Schwarz, C. Merschjann, W. Schnick, X. Wang, M.J. Bojdys; Nat. Rev. Mater. 2017, 2, 17030 Li12P3N9 with Non-Condensed [P3N9]12--Rings and its High-Pressure Polymorph Li4PN3 with Infinite Chains of PN4-Tetrahedra; E.-M. Bertschler, R. Niklaus, W. Schnick; Chem. Eur. J. 2017, 23, 9592 Li24Sr12[Si24N47O]F:Eu2+ - Structure and Luminescence of an Orange Phosphor; K. Horky, W. Schnick; Chem. Mater. 2017, 29, 4590 Ammonothermal Synthesis of Earth-abundant Nitride Semiconductors ZnSiN2 and ZnGeN2 and Dissolution Monitoring by In Situ X-ray Imaging; J. Häusler, S. Schimmel, P. Wellmann, W. Schnick; Chem. Eur. J. 2017, 23, 12275

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Crystal Structure and Nontypical Deep-Red Luminescence of Ca3Mg[Li2Si2N6]:Eu2+; C. Poesl, W. Schnick; Chem. Mater. 2017, 29, 3778 The Crystal Structure of Nitridomagnesogermanate Ba[Mg3GeN4]:Eu2+ and Theo-retical Calculations of Its Electronic Properties; C. Poesl, R. Niklaus, W. Schnick; Eur. J. Inorg. Chem. 2017, 2422 First-principle and Experimental Characterization of the Electronic Properties of CaGaSiN3 and CaAlSiN3: The Impact of Chemical Disorder; R. Niklaus, J. Minár, J. Häusler, W. Schnick; Phys. Chem. Chem. Phys. 2017, 19, 9292 Li47B3P14N42 – A Lithium Nitridoborophosphate with [P3N9]12--, [P4N10]10--, and the Unprecedented [B3P3N13]15--Ion; E.-M. Bertschler, T. Bräuniger, C. Dietrich, J. Janek, W. Schnick; Angew. Chem. 2017, 129, 4884; Angew. Chem. Int. Ed. 2017, 56, 4806 Increased Synthetic Control - Gaining Access to Predicted Mg2Si5N8 and β-Ca2Si5N8; P. Bielec, W. Schnick; Angew. Chem. 2017, 129, 4888; Angew. Chem. Int. Ed. 2017, 56, 4810 An Unusual Nitride Network of Aluminum-centered Octahedra and Phosphorus-centered Tetrahedra and Structure Determination from Microcrystalline Samples; L. Neudert, F. Heinke, T. Bräuniger, F. Pucher, G.B. Vaughan, O. Oeckler, W. Schnick; Chem. Commun. 2017, 53, 2709 Ca4Mg5Ge3N10 and Sr2Mg3GaN4.33 – Two Mg-containing Nitrides and their Struc-tural Relations to (Sr,Ba)2Si5N8; C. Poesl, W. Schnick; Eur. J. Inorg. Chem. 2017, 1498 Anti-Perovskite Nitridophosphate Oxide Ho3[PN4]O by High-Pressure Metathesis; S.D. Kloß, N. Weidmann, W. Schnick; Eur. J. Inorg. Chem. 2017, 1930 Luminescence of the Narrow-band Red Emitting Nitridomagnesosilicate Li2(Ca1-xSrx)2[Mg2Si2N6]:Eu2+ (x = 0‒0.06); P. Strobel, V. Weiler, C. Hecht, P.J. Schmidt, W. Schnick; Chem. Mater. 2017, 29, 1377 LiCa4Si4N8F and LiSr4Si4N8F: Nitridosilicate Fluorides with a BCT-Zeolite-Type Network Structure; K. Horky, W. Schnick; Eur. J. Inorg. Chem. 2017, 1107 Ba32[Li15Si9W16N67O5]: A Barium-containing Oxonitridolithotungstosilicate with a Highly Condensed Network Structure; K. Horky, W. Schnick; Eur. J. Inorg. Chem. 2017, 1100

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Li18P6N16 – A Lithium Nitridophosphate with Unprecedented Tricyclic [P6N16]18− Ions; E.-M. Bertschler, C. Dietrich, J. Janek, W. Schnick; Chem. Eur. J. 2017, 23, 2185 Layered Nitridomagnesogallates CaMg2GaN3 and CaMg2Ga2N4; C. Poesl, L. Neudert, W. Schnick; Eur. J. Inorg. Chem. 2017, 1067 Ammonothermal Synthesis of Novel Nitrides: Case Study on CaGaSiN3; J. Häu-sler, L. Neudert, M. Mallmann, R. Niklaus, A.-C.L. Kimmel, N.S.A. Alt, E. Schlücker, O. Oeckler, W. Schnick; Chem. Eur. J. 2017, 23, 2583 High-pressure Synthesis of Melilite-Type Rare-Earth Nitridophosphates RE2P3N7 and a Ba2Cu[Si2O7]-type Polymorph; S.D. Kloß, N. Weidmann, R. Niklaus, W. Schnick; Inorg. Chem. 2016, 55, 9400 Insight in the 3D Morphology of Silica-based Nanotubes Using Electron Microsco-py; T. Dennenwaldt, A. Wisnet, S.J. Sedlmaier, M. Döblinger, W. Schnick, C. Scheu; Micron 2016, 90, 6 Ca2Mg5GeN6 – A Layered Nitridomagnesogermanate; C. Poesl, W. Schnick; Z. Anorg. Allg. Chem. 2016, 642, 882 Field-induced Transition of the Magnetic Ground State from A-type Antiferromag-netic to Ferromagnetic Order in CsCo2Se2; F. v. Rohr, A. Krzton-Maziopa, V. Pomjakushin, H. Grundmann, Z. Guguchia, W. Schnick, A. Schilling; J. Phys.: Cond. Matter 2016, 28, 276001 Experiment-Driven Modeling of Crystalline Phosphorus Nitride P3N5: Wide-Ranging Implications from a Unique Structure; T.M. Tolhurst, C. Braun, T.D. Boyko, W. Schnick, A. Moewes; Chem. Eur. J. 2016, 22, 10475 Ba1.63La7.39Si11N23Cl0.42:Ce3+ - A Nitridosilicate Chloride with a Zeolite-like Struc-ture; P. Schultz, D. Durach, W. Schnick, O. Oeckler; Z. Anorg. Allg. Chem. 2016, 642, 603 From Minor Side Phases to Bulk Samples of Lanthanum Oxonitridosilicates – An Investigation with Microfocused Synchrotron Radiation; D. Durach, P. Schultz, O. Oeckler, W. Schnick; Inorg. Chem. 2016, 55, 3624 CdP2N4 and MnP2N4 – Ternary Transition-Metal Nitridophosphates; F.J. Pucher, F.W. Karau, J. Schmedt auf der Günne, W. Schnick; Eur. J. Inorg. Chem. 2016, 1497

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Ca18.75Li10.5[Al39N55]:Eu2+ - Supertetrahedron Phosphor for Solid-State Lighting; P. Wagatha, P. Pust, V. Weiler, A.S. Wochnik, P.J. Schmidt, C. Scheu, W. Schnick; Chem. Mater. 2016, 28, 1220 M2PO3N (M = Ca, Sr) – ortho-Oxonitridophosphates with β-K2SO4 Structure Type; A. Marchuk, P. Schultz, C. Hoch, O. Oeckler, W. Schnick; Inorg. Chem. 2016, 55, 974 A 45Sc-NMR and DFT Calculation Study of Crystalline Scandium Compounds; T. Bräuniger, A.J. Hofmann, I.L. Moudrakovski, C. Hoch, W. Schnick; Solid State Sci. 2016, 51, 1 Electronic Structure, Band Gap, and Thermal Quenching of Sr[Mg3SiN4]:Eu2+ in Comparison to Sr[LiAl3N4]:Eu2+; T.M. Tolhurst, S. Schmiechen, P. Pust, P. Schmidt, W. Schnick, A. Moewes; Adv. Opt. Mater. 2016, 4, 584 Lanthanum (Oxo)nitridosilicates: From Ordered to Disordered Crystal Structures; D. Durach, W. Schnick; Z. Anorg. Allg. Chem. 2016, 642, 101 Patents LED Phosphor Comprising Bow-tie Shaped A2N6 Building Blocks; P.J. Schmidt, P.J. Strobel, S.F. Schmiechen, C.S. Hecht, V. Weiler, W. Schnick; PCT Int. Appl. 2016, WO 2016075021, A1Koninklijke Philips NV, Ludwig-Maximilians-Universität München Other Activities Management Board Department of Chemistry, University of Munich LMU; Mem-ber of the Scientific Council / Board of Trustees Fonds der Chemischen Industrie FCI; Member of the Advisory Council of the Dr. Klaus Römer Foundation, Mu-nich; Member of the Editorial Advisory Boards of the scientific journals Chemistry of Materials, Journal of Solid State Chemistry, Zeitschrift für Anorganische und Allgemeine Chemie, Zeitschrift für Naturforschung B (Chemical Sciences).

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Chemistry Education Prof. Dr. rer. nat. Stefan Schwarzer Born 1981 in Vechta, 2002–2009 studied chemistry University of Oldenburg, 2010 PhD degree in the group of Prof. Dr. M.S Wickleder University of Oldenburg, 2010–2016 postdoctoral researcher IPN Kiel, 2014–2017 (substitute)teacher at sec-ondary/comprehensive schools Kiel, 2016–2017 head of junior research group IPN Kiel, 2016–2017 visiting professor for chemistry education LMU Munich, 2017–present professor for chemistry education, LMU Munich Research Topics Public outreach, out-of-school learning, student labs, development of school exper-iments, authentic image of science, research into teaching and learning Honors, Awards, Memberships Fachgruppe Chemieunterricht (FGCU) der GDCh Verein zur Förderung des mathematischen und naturwissenschaftlichen Unterrichts (MNU), Gesellschaft für Didaktik der Chemie und Physik (GDCP) örderverein Chemie-Olympiade (FChO) Extramural Research Funding DFG: Project number 13266514 Lehrerbildung@LMU (BMBF) WACKER Chemie AG Publications – Scientific Papers M. Bremer, R. Reinke, B. Hesseler, M. Taale, D. Ingwersen, S. Schwarzer, C. Selhuber-Unkel, M. Gerken: Non-Covalent Spiropyran Coatings for Photo-Induced Wettability Switching. Journal of Nanomaterials 2017, 1-6.

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S. Schwarzer, P. Liedtke, R. Adelung: Untouchable: Erstaunliches auf der Oberflä-che - Untersuchung der Benetzbarkeit von unpolaren, mikro- und nanostrukturier-ten sowie heißen Oberflächen. Der mathematische und naturwissenschaftliche Unterricht (MNU) 2017, 70, 327-334. S. Schwarzer, I. Stamer, M. Baum, C. Bethke, D. Ingwersen, P. Liedtke, R. Ade-lung, R. Herges, I. Parchmann: Struktur-Eigenschafts-Beziehungen an aktuellen Beispielen aus der Forschung weitergedacht: „Mikro-“ und „nano-“Schichten sowie Oberflächen für Schule und Schülerlabor. CHEMKON 2017, 24, 192-208. M. Forster, K. Hock, S. Schwarzer: Dünnschichtchromatographie von GeloMyrtol® forte - Vermittlung von naturwissenschaftlichen Arbeitsweisen an einem alltags-orientierten Beispiel. Naturwissenschaften im Unterricht: Chemie 2017, 28, 26-33. S. Schwarzer, A. Betke, C. Logemann, M.S. Wickleder: Oxidizing Rhodium with sulfuric acid: The sulfates Rh2(SO4)3 and Rh2(SO4)3∙2H2O, Eur. J. Inorg. Chem. 2017, 3, 752-758. S. Schwarzer, M. Elbahri, R. Abdelaziz, T. Wilke: Wenn ein Wassertropfen zum Nanolabor wird - Gold-Nanopartikel und Gold aus dem Tropfenreaktor. CHEMKON, 2016, 23, 188-190. S. Schwarzer, P. Liedtke, R. Adelung: St. Pauli und das Phänomen der Wasser-strahlreflexion? Natürliche, nano- und mikrostrukturierte Oberflächen mit Lotos-Effekt inspirieren zur Untersuchung neuer Materialien. Naturwissenschaften im Unterricht: Chemie, 2016, 27, 34-38. I. Parchmann, S. Schwarzer, A. Staubitz, R. Adelung: Funktions- und Verbundma-terialien verstehen und gestalten – Beispiele fächerverbindender Zusammenarbeit. Naturwissenschaften im Unterricht: Chemie, 2016, 27, 18-22.

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Inorganic Chemisty Dr. Jörg Stierstorfer Jörg Stierstorfer was born in Munich (Germany) in 1979. He received his Diploma (degree) in Chemistry at the Ludwig-Maximilian University in Munich in 2005. Afterwards he worked on his PhD as a scientific co-worker in the research group of Prof. Dr. Thomas Klapötke. His scientific interests cover the whole area of synthe-sis, characterization, scale-up as well as performance and safety testing of new en-ergetic materials, especially primary and secondary explosives, nitrogen-rich pro-pellants, high-oxidizers and pyrotechnical compositions. Jörg Stierstorfer received his PhD with honors in March 2009. His dissertation with the title “Advanced En-ergetic Materials Based on 5-Aminotetrazole – Synthesis, Characterization and Scale-Up” contains more than 150 new X-ray structures. After a short post-Doc time at the University of Maryland (USA) he is working as senior researcher hold-ing an AOR position in the group of Prof. Klapötke. In 2007 and 2011, he was twice awarded the “Römer Prize” of the University of Munich for his excellent sci-entific achievements. 2017 he applied successfully to work on his habilitation at the department of chemistry at LMU Munich. Research Topics Synthesis and characterization of nitrogen-rich transition metal complexes and functionalized metal-organic-frameworks (MOFs). Stabilization of highly reactive and endothermic ligands by metal coordination. Investigation of the photoactivity and magnetic behavior of energetic coordination compounds for potential applica-tion as optical switches or initiators. Publications N. Szimhardt, Maximilian H. H. Wurzenberger, A. Beringer, L. J. Daumann, J. Stierstorfer, Coordination chemistry with 1-methyl-5H-tetrazole: cocrystallization, laser-ignition, lead-free primary explosives - one ligand, three goals, J. Mater. Chem. A, 2017, 5, 23753–23765. N. Szimhardt, J. Stierstorfer, Methylsemicarbazide as Ligand in Late 3d Transition Metal Complexes, Chemistry – Europ. J. 2017, DOI: 10.1002/chem.201705030.

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N. Szimhardt, M. H. H. Wurzenberger, J. Stierstorfer, Copper(II) Chlorate Com-plexes – the Renaissance of a Forgotten and Misjudged Energetic Anion, J. Am. Chem. Soc. 2018, submitted. Patents only recent patents D. Fischer, T. M. Klapötke, J. Stierstorfer, Process for preparing 3,3'-Dinitro-5,5'-bis(1H-1,2,4-triazole), WO 2017 013206 A1. D. Fischer, T. M. Klapötke, J. Stierstorfer, Bis(3,4,5-trinitropyrazolyl)methane and bis(3,5-dinitro-4-aminopyrazolyl)methane as explosives, WO 2017 021029. Other Activities - Treasurer of the Münchener Chemische Gesellschaft (MChG) - Managing director at EMTO GmbH

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Inorganic Chemistry Apl. Prof. Dr. rer. nat. Dr.rer.nat.habil. Karlheinz Sünkel Born 1955 in Munich, study of chemistry at LMU Munich (1974-1979), PhD de-gree with Prof. Dr. W. Beck (1982), Jan.-Dez. 1983 University of Southern Cali-fornia at Los Angeles, with Prof. R. Bau, habilitation under mentoring by Prof. Dr. W. Beck (1990), Akad. Oberrat since Nov. 1994, Privatdozent since Jan. 1991, apl. Prof. since Feb. 1998 Research Topics Synthesis and reactivity of ring-functionalized cyclopentadienyl complexes, organ-ometallic coordination polymers, organometallic reaction mechanisms, synthesis and photo-physical properties of cyclometallated Ir- and Pt-complexes. Extramural Research Funding Nitrochemie AG, Aschau: "Papierverfestigung säuregeschädigter Papiere" Publications Organometallic Lewis Acids, Part LXII. Chiral Carbonyl-Cyclopentadienyl-Triphenylphosphine-Iron and -Ruthenium Complexes with Tertiary Nitriles [CpM(CO)(PPh3)(N C-CR1R2R3)]+ BF4- (M = Fe, Ru). Missling, Ch.; Sünkel, K.; Langhals, H.; Beck, W.; Z. Anorg. Allg. Chem. (2017), 643(20), 1262-1268. DOI:10.1002/zaac.201700235 2-Pyridylmetallocenes, Part VI. Double Cycloplatination of 1,1'-Dipyridylferrocene. Synthesis and Molecular Structure of σ-{Pt2Cl2(DMSO)2[Fe[η5-(C5H3(2-C5H4N)2]2]} Branzan, R.; Sünkel, K. Z. Anorg. . Allg. Chem. (2017), 643(21), 1364-1367, DOI:10.1002/zaac.201700264. Bis-cyclometalated rhodium- and iridium-complexes with the 4,4'-dichloro-2,2'-bipyridine ligand. Evaluation of their photophysical properties and biological activ-ity, Graf, M.; Gothe, Y.; Metzler-Nolte, N.; Czerwieniec, R.; Sünkel, K. Inorg. Chim. Acta (2017), 463, 36-43. DOI:10.1016/j.ica.2017.04.006 Cyclometalated Iridium(III) and Rhodium(III) Complexes Containing Naphthy-ridine Ligands: Synthesis, Characterization and Biological Studies. M. Graf, Y. Gothe, N. Metzler-Nolte, K. Sünkel, Z. anorg. allg. Chem. (2017), 643(4), 306-310. DOI:10.1002/zaac.201600378

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Biochemistry Prof. Dr. rer. nat. Roland Beckmann Born 1965 in Luzern / Switzerland, Roland Beckmann studied Biochemistry at the Freie Universität Berlin from 1986-1992 where he also received his PhD in 1995. He then joined Prof. Dr. Günter Blobel’s Lab at Rockefeller University, New York, as a Postdoctoral fellow from 1995-2000. From 2001 until 2006 he worked as a Group Leader of an independent Junior group of the VolkswagenStiftung at the Charitè, Humboldt University, Berlin. Since 2006 he holds his current position as a W3-full professor at the LMU Munich. Research Topics Structural Biochemistry of translation and co-translational events: Cryo-electron microscopy in combination with single particle analysis. Mechanism of protein tar-geting and translocation, structural basis of eukaryotic translation termination and recycling, mechanisms of translation mediated mRNA surveillance, ribosome bio-genesis. Honors, Awards, Memberships Member of the German National Academy of Sciences (Leopoldina) Member of the European Molecular Biology Organization (EMBO) Referee for scientific journals, including Science, Nature and Cell Member of the DFG study section ‘Biophysics and Biochemistry’ Extramural Research Funding European Research Council Advanced Grant “CRYOTRANSLATION” Excellence Cluster Center for Integrated Protein Sciences Munich (DFG and the Graduate School Quantitative Biology Munich (DFG and the Federal Ministry of Education and Research) Collaborative Research Center 646 (German Research Council) “Regulatory Net-works in Genome Expression and Maintenance” Research Group FOR 967 (German Research Council) “Ribosomal tunnel exit lig-ands”

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Research Group FOR 1805 (German Research Council) “Translational dynamics and accuracy” Student Research Training Group 1721 (German Research Council) “Integrated analysis of protein complexes and hybrid methods in genome biology” Fellowships from EMBO, Swiss Foundation, and Boehringer Ingelheim Fonds to postdocs and students Publications – Scientific Papers Sturm M, Cheng J, Baßler J, Beckmann R, Hurt E. Interdependent action of KH domain proteins Krr1 and Dim2 drive the 40S platform assembly. Nat Commun. 2017 Dec 20;8(1):2213. doi: 10.1038/s41467-017-02199-4. Kater L, Thoms M, Barrio-Garcia C, Cheng J, Ismail S, Ahmed YL, Bange G, Kressler D, Berninghausen O, Sinning I, Hurt E, Beckmann R. Visualizing the As-sembly Pathway of Nucleolar Pre-60S Ribosomes. Cell. 2017 Dec 14;171(7):1599-1610.e14. doi: 10.1016/j.cell.2017.11.039. Heuer A, Thomson E, Schmidt C, Berninghausen O, Becker T, Hurt E, Beckmann R. Cryo-EM structure of a late pre-40S ribosomal subunit from Saccharomyces cerevisiae. Nat Struct Mol Biol. 2017 Dec;24(12):1107-1115. doi: 10.1038/nsmb.3495 Huter P, Arenz S, Bock LV, Graf M, Frister JO, Heuer A, Peil L, Starosta AL, Wohlgemuth I, Peske F, Nováček J, Berninghausen O, Grubmüller H, Tenson T, Beckmann R, Rodnina MV, Vaiana AC, Wilson DN. Structural Basis for Polypro-line-Mediated Ribosome Stalling and Rescue by the Translation Elongation Factor EF-P. Mol Cell. 2017 Nov 2;68(3):515-527.e6. doi: 10.1016/j.molcel.2017.10.014. Sarkar A, Thoms M, Barrio-Garcia C, Thomson E, Flemming D, Beckmann R, Hurt E. Preribosomes escaping from the nucleus are caught during translation by cytoplasmic quality control. Nat Struct Mol Biol. 2017 Dec;24(12):1107-1115. doi: 10.1038/nsmb.3495 Cheng J, Kellner N, Berninghausen O, Hurt E, Beckmann R. 3.2-Å-resolution structure of the 90S preribosome before A1 pre-rRNA cleavage. Nat Struct Mol Biol. 2017 Nov;24(11):954-964. doi: 10.1038/nsmb.3476

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Matsuo Y, Ikeuchi K, Saeki Y, Iwasaki S, Schmidt C, Udagawa T, Sato F, Tsuchi-ya H, Becker T, Tanaka K, Ingolia NT, Beckmann R, Inada T. Ubiquitination of stalled ribosome triggers ribosome-associated quality control. Nat Commun. 2017 Jul 31;8(1):159. doi: 10.1038/s41467-017-00188-1 Florin T, Maracci C, Graf M, Karki P, Klepacki D, Berninghausen O, Beckmann R, Vázquez-Laslop N, Wilson DN, Rodnina MV, Mankin AS. An antimicrobial pep-tide that inhibits translation by trapping release factors on the ribosome. Nat Struct Mol Biol. 2017 Sep;24(9):752-757. doi: 10.1038/nsmb.3439 Su T, Cheng J, Sohmen D, Hedman R, Berninghausen O, von Heijne G, Wilson DN, Beckmann R. The force-sensing peptide VemP employs extreme compaction and secondary structure formation to induce ribosomal stalling. Elife. 2017 May 30;6. pii: e25642. doi: 10.7554/eLife.25642. Beckert B, Abdelshahid M, Schäfer H, Steinchen W, Arenz S, Berninghausen O, Beckmann R, Bange G, Turgay K, Wilson DN. Structure of the Bacillus subtilis hibernating 100S ribosome reveals the basis for 70S dimerization. EMBO J. 2017 May 3. pii: e201696189. doi: 10.15252/embj.201696189. Yamashita Y, Takamatsu S, Glasbrenner M, Becker T, Naito S, Beckmann R. Su-crose sensing through nascent peptide-meditated ribosome stalling at the stop co-don of Arabidopsis bZIP11 uORF2. FEBS Lett. 2017 May;591(9):1266-1277. doi: 10.1002/1873-3468.12634. Epub 2017 Apr 10. Heuer A, Gerovac M, Schmidt C, Trowitzsch S, Preis A, Kötter P, Berninghausen O, Becker T, Beckmann R, Tampé R. Structure of the 40S-ABCE1 post-splitting complex in ribosome recycling and translation initiation. Nat Struct Mol Biol. 2017 May;24(5):453-460. doi: 10.1038/nsmb.3396. Epub 2017 Apr 3. Nilsson OB, Nickson AA, Hollins JJ, Wickles S, Steward A, Beckmann R, von Heijne G, Clarke J. Cotranslational folding of spectrin domains via partially struc-tured states. Nat Struct Mol Biol. 2017 Mar;24(3):221-225. doi: 10.1038/nsmb.3355. Epub 2017 Jan 23. Schmidt C, Kowalinski E, Shanmuganathan V, Defenouillère Q, Braunger K, Heu-er A, Pech M, Namane A, Berninghausen O, Fromont-Racine M, Jacquier A, Conti E, Becker T, Beckmann R. The cryo-EM structure of a ribosome-Ski2-Ski3-Ski8 helicase complex. Science. 2016 Dec 16;354(6318):1431-1433.

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Kedrov A, Wickles S, Crevenna AH, van der Sluis EO, Buschauer R, Berninghau-sen O, Lamb DC, Beckmann R. Structural Dynamics of the YidC:Ribosome Com-plex during Membrane Protein Biogenesis. Cell Rep. 2016 Dec 13;17(11):2943-2954. doi: 10.1016/j.celrep.2016.11.059. Huter P, Müller C, Beckert B, Arenz S, Berninghausen O, Beckmann R, Wilson DN. Structural basis for ArfA-RF2-mediated translation termination on mRNAs lacking stop codons. Nature. 2017 Jan 26;541(7638):546-549. doi: 10.1038/nature20821. Epub 2016 Dec 1. Kiosze-Becker K, Ori A, Gerovac M, Heuer A, Närenberg-Goloub E, Rashid UJ, Becker T, Beckmann R, Beck M, Tampé R. Structure of the ribosome post-recycling complex probed by chemical cross-linking and mass spectrometry. Nat Commun. 2016 Nov 8;7:13248. doi: 10.1038/ncomms13248. Sarkar A, Pech M, Thoms M, Beckmann R, Hurt E. Ribosome-stalk biogenesis is coupled with recruitment of nuclear-export factor to the nascent 60S subunit. Nat Struct Mol Biol. 2016 Dec;23(12):1074-1082. doi: 10.1038/nsmb.3312. Epub 2016 Oct 24. Kornprobst M, Turk M, Kellner N, Cheng J, Flemming D, Koš-Braun I, Koš M, Thoms M, Berninghausen O, Beckmann R, Hurt E. Architecture of the 90S Pre-ribosome: A Structural View on the Birth of the Eukaryotic Ribosome. Cell. 2016 Jul 14;166(2):380-93. doi: 10.1016/j.cell.2016.06.014. Deeng J, Chan KY, van der Sluis EO, Berninghausen O, Han W, Gumbart J, Schul-ten K, Beatrix B, Beckmann R. Dynamic Behavior of Trigger Factor on the Ribo-some. J Mol Biol. 2016 Sep 11;428(18):3588-602. doi: 10.1016/j.jmb.2016.06.007. Arenz S, Bock LV, Graf M, Innis CA, Beckmann R, Grubmüller H, Vaiana AC, Wilson DN. A combined cryo-EM and molecular dynamics approach reveals the mechanism of ErmBL-mediated translation arrest. Nat Commun. 2016 Jul 6;7:12026. doi: 10.1038/ncomms12026. Arenz S, Abdelshahid M, Sohmen D, Payoe R, Starosta AL, Berninghausen O, Hauryliuk V, Beckmann R, Wilson DN. The stringent factor RelA adopts an open conformation on the ribosome to stimulate ppGpp synthesis. Nucleic Acids Res. 2016 Jul 27;44(13):6471-81. doi: 10.1093/nar/gkw470. Epub 2016 May 25.

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Lässig C, Matheisl S, Sparrer KM, de Oliveira Mann CC, Moldt M, Patel JR, Goldeck M, Hartmann G, GarcÃa-Sastre A, Hornung V, Conzelmann KK, Beck-mann R, Hopfner KP. Correction: ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA. Elife. 2016 Mar 2;5. pii: e14954. doi: 10.7554/eLife.14954. No abstract available. Marino J, von Heijne G, Beckmann R. Small protein domains fold inside the ribo-some exit tunnel. FEBS Lett. 2016 Mar;590(5):655-60. doi: 10.1002/1873-3468.12098. Epub 2016 Feb 25. Wilson DN, Arenz S, Beckmann R. Translation regulation via nascent polypeptide-mediated ribosome stalling. Curr Opin Struct Biol. 2016 Apr;37:123-33. doi: 10.1016/j.sbi.2016.01.008. Epub 2016 Feb 7. Review. Schmidt C, Becker T, Heuer A, Braunger K, Shanmuganathan V, Pech M, Berninghausen O, Wilson DN, Beckmann R. Structure of the hypusinylated eukar-yotic translation factor eIF-5A bound to the ribosome. Nucleic Acids Res. 2016 Feb 29;44(4):1944-51. doi: 10.1093/nar/gkv1517. Epub 2015 Dec 28.

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Biochemistry Dr.-Ing. Stefan Canzar 1998-2004 study of computer science at TU Munich, 2005-2008 doctoral research-er at the Max Planck Institute for Informatics, department of algorithms and com-plexity led by Kurt Mehlhorn, 2008 bi-national doctoral degree in computer science from Saarland University (Germany) and Université Henri Poincaré (France), 2009-2011 postdoctoral fellow at the Centrum Wiskunde & Informatica (Amster-dam), 2012-2014 postdoctoral fellow in the group of Steven Salzberg at the Johns Hopkins Institute of Genetic Medicine (Baltimore), 2014-2016 research assistant professor at the Toyota Technological Institute at Chicago, since 2016 research group leader at the Gene Center at LMU Munich. Research Topics Computational Biology, Genomics & Transcriptomics, Algorithm Engineering, NGS Data Analysis, Combinatorial Optimization. Extramural Research Funding BAYHOST mobility grant Publications – Scientific Papers K.-J. Yoon, F. Rojas Ringeling, C. Vissers, F. Jacob, M. Pokrass, D. Jimenez-Cyrus,Y. Su, N.-S. Kim, Y. Zhu, L. Zheng, S. Kim, X. Wang, L. C. Doré , P. Jin, S. Regot, X. Zhuang, S. Canzar , C. He, G. Ming, and H. Song. Temporal Control of Mammalian Cortical Neurogenesis by m6 A Methylation. Cell, 171(4):877-889, 2017. S. Canzar, K. M. Elbassioni, A. Elmasry, and R. Raman. On the Approximability of the Maximum Interval Constrained Coloring Problem. Discrete Optimization, http://dx.doi.org/10.1016/j.disopt.2017.09.002, Epub 2017. Z. Kuang, J. D. Boeke, and S. Canzar. The dynamic landscape of fission yeast mei-osis alternative-splice isoforms. Genome Research , 27:145–156, 2017.

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S. Canzar, K. E. Neu, Q. Tang, P. C. Wilson, and A. A. Khan. BASIC: BCR as-sembly from single cells. Bioinformatics, 33(3):425–427, 2016. S. Hashemifar, J. Ma, H. Naveed, S. Canzar, and J. Xu. ModuleAlign: Module-based global alignment of protein-protein interaction networks. Bioinformatics, 32(17):658–664, 2016. Canzar, S. Andreotti, D. Weese, G. W. Klau, and K. Reinert. CIDANE: Compre-hensive isoform discovery and abundance estimation. Genome Biology, 17(1):1–18, 2016. S. Canzar, K. Elbassioni, M. Jones, and J. Mestre. Resolving conflicting predictions from multi-mapping reads. Journal of Computational Biology, 23(3):203–217, 2016. S. Canzar and L. Florena. Computational Methods for Transcript Assembly from RNA-seq reads. Computational Methods for Next Generation Sequencing Data Analysis (eds I. Mandoiu and A. Zelikovsky), John Wiley & Sons, Inc., Hoboken, NJ, USA, 199–216, 2016. Other Activities PC member Bioinformatics 2016, PC member RECOMB-Seq (Massive Parallel Sequencing) and RECOMB-CCB (Computational Cancer Biology) 2016, PC member ECCB 2016, PC member Computational Intelligence methods for Bioin-formatics and Biostatistics (CIBB) 2017, PC member ACM International Confer-ence on Bioinformatics, Computational Biology, and Health Informat-ics (BCB) 2017. Reviewer for Nucleic Acids Research, Bioinformatics, BMC Bioinformatics, Na-ture Communications, IEEE/ACM Transactions on Computational Biology and Bi-oinformatics, Briefings in Bioinformatics, Algorithms for Molecular Biology, PLOS Computational Biology, ISMB 2017, RECOMB 2016 & 2017, RECOMB-Seq 2016 & 2017, ACM-BCB 2017, CIBB 2017, WALCOM 2017

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Biochemistry - Max Planck Institute of Biochemistry Prof. Dr. rer. nat. Elena Conti Born 1967 in Varese (Italy); 1986-1991 Chemistry Degree at University of Pavia (Italy); 1996 PhD degree by the Faculty of Physical Sciences at Imperial College of Science, Technology and Medicine, London (UK) in the group of Dr Peter Brick; 1997-1999 Postdoctoral fellow at The Rockefeller University, New York (USA) in the group of Dr. John Kuriyan; 1999-2007 Group Leader at the European Molecu-lar Biology Laboratory, EMBL, Heidelberg (Germany); 2007 Max Planck Director and Scientific Member at the Max Planck Institute of Biochemistry, heading the Structural Cell Biology Department; 2007, Honorary Professor at LMU Munich. Research Topics RNA metabolism: Molecular mechanisms of RNA quality control, RNA transport and RNA degradation. Unwinding RNA helicases, RNA binding proteins, nucleas-es. Structural biology, X-ray crystallography, biochemistry, biophysics. Honors, Awards, Memberships Theodor Bücher medal (FEBS) Member of the European Molecular Biology Organization (EMBO) Member of International Max Planck Research School, Martinsried Editor RNA Journal Member of the Editorial Board Current Opinion Structural Biology Extramural Research Funding European Research Council Advanced Grant “DEAD2THEEND” Marie Curie Initial Training Network RNPnet Excellence Cluster Center for Integrated Protein Sciences Munich (DFG and the Federal Ministry of Education and Research) Graduate School Quantitative Biology Munich (DFG and the Federal Ministry of Education and Research) Collaborative Research Center 646 (German Research Council) “Regulatory Net-works in Genome Expression and Maintenance” Collaborative Research Center 1035 (German Research Council) “Control of pro-

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tein function by conformational switching”. Collaborative Research Group FOR1680 (German Research Council) “Unravelling the prokaryotic immune system” Student Research Training Group 1721 (German Research Council) “Integrated analysis of protein complexes and hybrid methods in genome biology” Fellowships from EMBO and Boehringer Ingelheim Fonds to postdocs and students Publications – Scientific Papers Reconstitution of the complete pathway of ITS2 processing at the pre-ribosome. Fromm L, Falk S, Flemming D, Schuller JM, Thoms M, Conti E, Hurt E. Nat Commun. 8, 1787 Pubmed Structural insights into the interaction of the nuclear exosome helicase Mtr4 with the pre-ribosomal protein Nop53. Falk S, Tants JN, Basquin J, Thoms M, Hurt E, Sattler M, Conti E. RNA. 23, 1780-1787. Mpp6 Incorporation in the Nuclear Exosome Contributes to RNA Channeling through the Mtr4 Helicase. Falk S, Bonneau F, Ebert J, Kögel A, Conti E. Cell Rep. 20, 2279-2286. Sen1 has unique structural features grafted on the architecture of the Upf1-like helicase family. Leonaitė B, Han Z, Basquin J, Bonneau F, Libri D, Porrua O, Conti E. EMBO J. 36, 1590-1604. Structure of a SMG8-SMG9 complex identifies a G-domain heterodimer in the NMD effector proteins. Li L, Lingaraju M, Basquin C, Basquin J, Conti E. RNA. 23, 1028-1034. The cryo-EM structure of a ribosome-Ski2-Ski3-Ski8 helicase complex. Schmidt C, Kowalinski E, Shanmuganathan V, Defenouillère Q, Braunger K, Heuer A, Pech M, Namane A, Berninghausen O, Fromont-Racine M, Jacquier A, Conti E, Becker T, Beckmann R. Science. 354, 1431-1433 Structure of the RBM7-ZCCHC8 core of the NEXT complex reveals connections to splicing factors. Falk S, Finogenova K, Melko M, Benda C, Lykke-Andersen S, Jensen TH, Conti E. Nat Commun. 2016 7, 13573. Structure of a Cytoplasmic 11-Subunit RNA Exosome Complex. Kowalinski E, Kögel A, Ebert J, Reichelt P, Stegmann E, Habermann B, Conti E. Mol 63, 125-34.

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Structural basis for the antagonistic roles of RNP-8 and GLD-3 in GLD-2 poly(A)-polymerase activity. Nakel K, Bonneau F, Basquin C, Habermann B, Eckmann CR, Conti E. RNA. 22, 1139-45. Molecular mechanism of processive 3' to 5' RNA translocation in the active subunit of the RNA exosome complex. Vukovic L, Chipot C, Makino DL, Conti E, Schulten K. J Am Chem Soc. 138, 4069-78. Other Activities EMBO Fellowship Committee, Review committee, EMBL, Grenoble (FR), Ar-menise-Harvard Foundation, Scholarship Advisory Committee, Managing Director, Max Planck Institute of Biochemistry (Munich). Meeting co-organizer: 107th Boehringer-Ingelheim Titisee conference on ‘RNA transport’ (Germany), Murnau Conference ‘Structural Biology of Macromolecular Transport’ (Germany) EMBO meeting, Nice (France) Keynote speaker/session chair: RNA meeting, Davos (Switzerland), Gordon con-ference, ‘Nucleic Acids’, New England (USA), EMBO Symposium: ‘Eukaryotic RNA turnover’, Strasbourg (France), EMBO Symposium ‘The complex life of mRNA’, Keystone meeting, ‘RNA protein interactions’, Santa Fe (USA) Reviewer for Science, Nature, Nature Structural and Molecular Biology, Cell, Mo-lecular Cell, EMBO J., RNA J, Nucleic Acids Research, Structure.

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Biochemistry - Max Planck Institute of Biochemistry Prof. Dr. med. Reinhard Fässler Born 1956 in Dornbirn/Austria, 1975-1981 study of Medicine at Univ. Innsbruck, 1981 MD degree, 1981-1988 clinical work in different hospitals/Zimbabwe and Austria, 1988-1992 Postdoctoral fellow at Whitehead Institute, Cambridge, USA, 1992 Group leader, Austrian Academy of Sciences, Salzburg, Austria, 1993-1998 Group leader at the Max Planck Institute for Biochemistry, Martinsried, Germany, 1998-2001 Professor and chairman, Department of Experimental Pathology, Lund University, Lund, Sweden; since 2001 Member of the Max Planck Society and Di-rector of the Department of Molecular Medicine, Martinsried, Germany. Research Topics Integrin; Adhesion signaling; Mechanosignalling; Cell migration; Mouse Genetics; Developmental Biology. Extramural Research Funding European Research Council Advanced Grant, DFG, BMBF, Max Planck Society Publications – Scientific Papers Theodosiou M., Widmaier M., Böttcher R.T., Rognoni E., Veelders M., Bharadwaj M., Lambacher A., Austen K., Müller D.J., Zent R., and Fässler R. (2016). Kindlin-2 cooperates with talin to activate integrins and induces cell spreading by directly binding paxillin. eLife, 5:e10130. doi: 10.7554/eLife.10130. Lukjanenko L., Jung M.J., Hegde N., Perruisseau-Carrier C., Migliavacca E., Rozo M., Karaz S., Jacot G., Schmidt M., Li L., Metairon S., Raymond F., Lee U., Sizzano F., Wilson D.H., Dumont N.A., Palini A., Fässler R., Steiner P., Descombes P., Rudnicki M.A., Fan C.M., von Maltzahn J., Feige J.N., and Bentzinger C.F. (2016). Loss of fibronectin from the aged stem cell niche affects the regenerative capacity of skeletal muscle in mice. Nature Med., 22: 897-905. Rognoni E., Ruppert R., and Fässler R. (2016). The Kindlin family: functions, sig-naling properties and implications for human disease. J. Cell Sci., 129: 17-27.

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Sun Z., Guo S.S., and Fässler R. (2016). Integrin-mediaed mechano-transduction. J. Cell Biol., 215: 445-446. Sun Z., Tseng H.-Y., Tan S., Senger F., Kurzawa L., Dedden D., Mizuno N., Wasik A.A., Thery M., Dunn A.R., and Fässler R. (2016). Kank family proteins activate Talin and reduce force transduction across integrins. Nature Cell Biol., 18: 941-953. Cerikan B., Colo G., Shaheen R., Gläßer C., Alkuraya F.S., Fässler R., and Schiebel E. (2016). Adams Oliver Syndrome gene DOCK6 inactivation highlights MRTF-A/SRF regulated ubiquitin-like ISG15 as RAC1, RHOA and CDC42 activi-ty balancer. Dev. Cell, 39: 28-43. Cheah M., Andrews M.R., Chew D.J., Verhaagen J., Fässler R., and Fawcett J.W. (2016). Expression of an Activated Integrin Promotes Sensory Axon Regeneration in the Spinal Cord. J. Neurosci., 36: 7283-7297. Hermann M.-R., Jakobson M., Colo G.P., Rognoni E., Jakobson M., Kupatt C., Posern G., and Fässler R. (2016). Integrins synergize to induce expression of the MRTF-A/SRF target gene ISG15 for promoting cancer cell invasion. J. Cell Sci., 129: 1391-1403. Bharadwaj M., Strohmeyer N., Schiller H., Helenius J., Beerenwinkel N., Fässler R., and Müller D. (2017). αV-class integrins play dual roles with α5β1 integrins to strengthen adhesion to fibronectin. Nature Comm., 8: 14348. doi: 10.1038/ncomms14348. Fujioka T., Kaneko N., Ajioka I., Nakaguchi K., Omata T., Ohba H., Fässler R., García-Verdugo J.M., Sekiguchi K., Matsukawa N., and Sawamoto K. (20127). Β1 integrin signaling promotes neuronal migration along vascular scaffolds in post-stroke brain. EBioMedicine, 16: 195-203. Lu Z., Mathew S., Chen J., Hadziselimovic A., Palamuttam R., Hudson B.G., Fässler R., Pozzi A., Sanders C.R., and Zent R. (2016). Implications of the different roles of the β1 and β3 transmembrane and cytoplasmic domains for integrin func-tion. eLife, 5:e18633. doi: 10.7554/eLife.18633 Strohmeyer N., Bharadwaj M., Fässler R., and Müller D. c-Src-dependent activa-tion of α5β1 and αV-class integrins strengthens fibroblast adhesion in response to mechanical stress. Nature Material, 16: 1262-1270.

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Volckaert T., Wang X., Chao C.-M., Yuan T., Sitaula A., Agha E.A., Redente E.F., Riches D.W., Bellusci S., Fässler R., and De Langhe S.P. Airway stem and epithe-lial cells employ Hippo signaling to control the stromal stem cell niche. Dev. Cell, 43: 48-59. Böttcher R.T., Veelders M., Rombaut P., Theodosiou M., Stradal T.E., Rottner K., Zent R., Faix J., Herzog F., and Fässler R. Kindlin-2 recruits paxillin and Arp2/3 to promote membrane protrusions during early cell spreading. J. Cell Biol., 216: 3785-3798. Ringer P., Colo G., Fässler R., and Grashoff C. (2017). Sensing the mechnao-chemical properties of the extracellular matrix. Matrix Biol., 64: 6-16. doi: 10.1016/j.matbio.2017.03.004. Kammerer P., Aretz J., and R. Fässler. (2017). Lucky kindlin: A cleaverloaf at the integrin tail. Proc. Natl. Acad.Sci. USA, 36: 2467-2469. Böttcher R.T., Sun Z., and Fässler R. (2017). A forceful connection: mechnaoregu-lation of oncogenic YAP. EMBO J., 36: 2467-2469. doi: 10.15252/embj.201797527. Mathew S., Palamuttam R.J., Mernaugh G., Ramalingam H., Lu Z., Zhang M.Z., Ishibe S., Critchley D.R., Fässler R., Pozzi A., Sanders C.R., Carroll T.J., and Zent R. (2017). Talin regulates integrin β1-dependent and -indepnedent cell functions in ureteric bud development. Development, 144: 4148-4158. Wujak L., Böttcher R.T., Pak O., Frey H., El Agha E., Chen Y., Schmitt S., Bel-lusci S., Schaefer L., Weissmann N., Fässler R., and Wygrecka M. (2017). Low density lipoproetin receptor-related protein 1 couples β1 integrin activation todeg-radation. Cell Mol Life Sci.

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Biochemistry Prof. Dr. ès sciences Klaus Förstemann 1992-1998 study of Biochemistry at the University of Tübingen and the University of Washington, Seattle (USA), 2002 PhD degree in the group of Prof. Dr. Joachim Lingner at the Swiss Institute for Experimental Cancer Research in Lausanne (Switzerland), 2003-2006 Postdoctoral fellow in the group of Prof. Dr. Phillip Za-more at the University of Massachusetts Medical School in Worcester (USA), 2006-2011 tenure-track professor LMU Munich, since 2011 W2-professor LMU Munich Research Topics Small RNA mediated gene regulation and genome protection, RNA biology, RNA-protein complexes, Drosophila genetics Extramural Research Funding Collaborative research center SFB646 Publications – Scientific Papers Kunzelmann S, Böttcher R, Schmidts, I Förstemann, K (2016). A Comprehensive Toolbox for Genome Editing in Cultured Drosophila Cells. G3 (Bethesda) Apr. 13 Wissel S, Kieser A, Yasugi T, Duchek P, Roitinger E, Gokcezade JF, Steinmann V, Gaul U, Mechtler K, Förstemann K, Knoblich JA, Neumüller RA (2016). A Com-bination of CRISPR/Cas9 and Standardized RNAi as a Versatile Platform for the Characterization of Gene Function. G3 (Bethesda). 2016 Jun 8. pii: g3.116.028571. doi: 10.1534/g3.116.028571. Schmidts I, Böttcher R, Mirkovic-Hösle M, Förstemann K. Homology directed re-pair is unaffected in the absence of siRNAs in Drosophila melanogaster, Nucleic Acids Res. 2016, 44: 8261-71

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Kunzelmann S, Förstemann K (2017): Reversible perturbations of gene regulation after genome editing in Drosophila cells, PLoS One 12(6):e0180135 Merk K, Breinig M, Böttcher R, Krebs S, Blum H, Boutros M and Förstemann K. Splicing stimulates siRNA Formation at Drosophila DNA Double-Strand Breaks, PLoS Genetics 2017 e1006861 Tants JN, Fesser S, Kern T, Stehle R, Geerlof A, Wunderlich C, Juen M, Hartlmül-ler C, Böttcher R, Kunzelmann S, Lange O, Kreutz C, Förstemann K, Sattler M. (2017): Molecular basis for asymmetry sensing of siRNAs by the Drosophila Loqs-PD/Dcr-2 complex in RNA interference, Nucleic Acids Research, doi: 10.1093/nar/gkx886 Other Activities Grant reviewer for Deutsche Forschungsgemeinschaft, Boehringer Ingelheim Fonds. Reviewer for Nucleic Acids Research, Journal of Biological Chemisrty, Bi-ological Chemistry, Genetics

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Biochemistry Prof. Dr. rer. nat. Ulrike Gaul Born 1960 in Möckmühl/Baden-Württemberg, 1978-1985 study of biochemistry and physics at the University of Tübingen, 1988 PhD (biology) in the group of Prof. Dr. Herbert Jäckle, Max-Planck-Institute for Developmental Biology (Tü-bingen), 1988 Postdoctoral fellow in the lab of Prof. Dr. Garrett Odell, University of Washington, Seattle, 1989-1993 Postdoctoral fellow in the lab of Prof. Dr. Gerald Rubin, University of California, Berkeley, 1993-2000 Assistant Professor, Head of Lab at the Rockefeller University, New York, 2000-2009 Associate Professor, Head of Lab at the Rockefeller University, New York, since 2009 Alexander von Humboldt-Professor and Center for Integrated Protein Sciences Munich (CIPSM)-Professor at the LMU Munich, 2014-2015 Director of the Department of Biochem-istry, LMU Munich. Research Topics Systems biology of gene regulation in developmental processes: transcription net-works in embryonic patterning, the role of the core promoter and of chromatin in transcriptional regulation; molecular and cellular mechanisms of glia cell function in the nervous system: the role of glia in homeostasis and neurodegeneration, de-velopment of the blood-brain barrier. Honors, Awards, Memberships Speaker of the Graduate School of Quantitative Biosciences Munich (2012-17) Alexander von Humboldt Professor Member of the European Molecular Biology Organization (EMBO) Member of the Excellence cluster “Center for Integrated Protein Science Munich” Member of International Max Planck Research School, Martinsried Member of the Center for Advanced Studies (CAS), Munich Member of Center for Nano Science Munich (CeNS) Member of the Strategy Committee, LMU Munich

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Extramural Research Funding Alexander von Humboldt Foundation, Alexander von Humboldt Professorship BMBF e:Bio-Innovationswettbewerb Systembiologie: “Systems Biology of Gene Expression – Dissecting the Core Promoter” (SysCore) Excellence Cluster Center for Integrated Protein Sciences Munich (DFG and the Federal Ministry of Education and Research) Graduate School of Quantitative Biosciences Munich (DFG and the Federal Minis-try of Education and Research) Collaborative Research Center 646 (German Research Council) “Regulatory Net-works in Genome Expression and Maintenance” Collaborative Research Center 1064 (German Research Council) “Chromatin Dy-namics” Large instrumentation grant (German Research Council) Publications – Scientific Papers A Combination of CRISPR/Cas9 and Standardized RNAi as a Versatile Platform for the Characterization of Gene Function. Wissel S, Kieser A, Yasugi T, Duchek P, Roitinger E, Gokcezade J, Steinmann V, Gaul U, Mechtler K, Förstemann K, Knoblich JA, Neumüller RA. G3 (Bethesda). 2016 Aug 9;6(8):2467-78. doi: 10.1534/g3.116.028571. Single-Molecule Imaging in Living Drosophila Embryos with Reflected Light-Sheet Microscopy. Greiss F, Deligiannaki M, Jung C, Gaul U, Braun D. Biophys J. 2016 Feb 23;110(4):939-46. doi: 10.1016/j.bpj.2015.12.035. Application of MultiColor FlpOut Technique to Study High Resolution Single Cell Morphologies and Cell Interactions of Glia in Drosophila. Batelli S, Kremer M, Jung C, Gaul U. J Vis Exp. 2017 Oct 20;(128). doi: 10.3791/56177. The glia of the adult Drosophila nervous system. Kremer MC, Jung C, Batelli S, Rubin GM, Gaul U. Glia. 2017 Apr;65(4):606-638. doi: 10.1002/glia.23115. Epub 2017 Jan 30. Dynamic analysis of the mesenchymal-epithelial transition of blood-brain barrier forming glia in Drosophila. Schwabe T, Li X, Gaul U. Biol Open. 2017 Feb 15;6(2):232-243. doi: 10.1242/bio.020669.

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Other Activities Baubeauftragte for new Research Center for Molecular Biosystems Munich (Bio-SysM, 2014-16); Member of the Scientific Advisory Board, Care for Rare Founda-tion, Leica Scientific Forum; Grant reviewer for National Institutes of Health, Na-tional Science Foundation, Max-Planck-Society, Boehringer Ingelheim Foundation, DFG, European Research Council; Reviewer for Cell, Nature, Neuron, Genes & Development, Developmental Biology, Proceedings of the National Academy of Sciences, PLoS Biology, Development, EMBO Journal, Mechanisms of Develop-ment, Developmental Biology, Oncogene, The Journal of Neuroscience, Neuron Glia Biology

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Biochemistry - Max Planck Institute of Biochemistry Prof. Dr. F. Ulrich Hartl Born 1957 in Essen, 1976-1982 study of medicine at Univ. Heidelberg, 1985, Dr. med degree in the group of Prof. Dr. Hans Schimassek, Institute of Biochemistry, Univ. Heidelberg, 1985-1986 Postdoctoral fellow and 1986-1990 group leader at Institute of Physiological Chemistry, Univ. of Munich in the group of Prof. Dr. Walter Neupert, interrupted in 1989 by a one year stay in the laboratory of William Wickner, Univ. California Los Angeles, 1990, Dr. med. habil. at Institute of Phys-iological Chemistry, Univ. of Munich, 1991-1992, Associate Member and 1993-1997, Member with tenure, Program in Cellular Biochemistry and Biophysics, Sloan-Kettering Institute, New York, Associate Professor/Full Professor of Cell Biology and Genetics, Cornell University, Graduate School of Medical Sciences, New York, 1994-1997, Associate Investigator, Howard Hughes Medical Institute, since 1997, Director at Max Planck Institute of Biochemistry, Martinsried, and Honorary Professor, Faculty of Medicine and Chemistry and Pharmacy, Univ. Mu-nich. Research Topics Cellular Biochemistry: Mechanisms of chaperone-assisted protein folding and as-sembly, and protein quality control. Mechanisms of protein misfolding and aggre-gation in neurodegenerative diseases. Honors, Awards, Memberships Albany Medical Center Prize, Albany, New York; Ernst Schering Prize; Vallee Visiting Professorship, Boston; E.B. Wilson Medal, American Society of Cell Bi-ology; Debrecen Award for Molecular Medicine, Hungary; Editorial board member of: The Journal of Cell Biology, The EMBO Journal, The Annual Review of Bio-chemistry, Molecular Cell, Proceedings of the National Academy of Sciences. Extramural Research Funding European Research Council Synergy Grant ToPAG Excellence Cluster Center for Integrated Protein Sciences Munich and Munich Cluster for Systems Neurology (SyNergy) (DFG and the Federal Ministry of Educa-

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tion and Research) Fellowships from EMBO and Boehringer Ingelheim Fonds to postdocs and students Publications – Scientific Papers Hayer-Hartl, M., Bracher, A., and Hartl, F.U. (2016). The GroEL-GroES chap-eronin machine: A nano-cage for protein folding. Trends Biochem Sci. 41, 62-76. Woerner, A.C., Frottin, F., Hornburg, D., Feng, L.R., Meissner, F., Patra, M., Tat-zelt, J., Mann, M., Winklhofer, K.F., Hartl, F.U. and Hipp, M.S. (2016). Cytoplas-mic protein aggregates interfere with nucleo-cytoplasmic transport of protein and RNA. Science 351, 173-176. Neudegger, T., Verghese, J., Hayer-Hartl, M., Hartl, F.U. and Bracher, A. (2016). Structure of human heat-shock transcription factor 1 in complex with DNA. Nat Struct Mol Biol. 23, 140-146. Landreh, M., Sawaya, M., Hipp, M., Eisenberg, D., Wüthrich, K. and Hartl, F. U. (2016). The formation, function and regulation of amyloids: Insights from struc-tural biology. J Intern Med. 280, 164-176. Choe, Y.-J., Park, S.-H., Hassemer, T., Körner, R., Vincenz-Donnelly, L., Hayer-Hartl, M. and Hartl, F.U. (2016). Failure of RQC machinery causes protein aggre-gation and proteotoxic stress. Nature 531, 191-195. Hartl, F.U. (2016). Cellular homeostasis and aging. Annual Rev Biochem. 85, 14.1–14.4 Balchin, D., Hayer-Hartl, M., and Hartl, F.U. (2016). In vivo aspects of protein folding and quality control. Science Jul 1;353(6294):aac4354. doi: 10.1126/science.aac4354. Kim, Y.E., Hosp, F., Frottin, F., Ge, H., Mann, M., Hayer-Hartl, M. and Hartl, F.U. (2016). Soluble oligomers of polyQ-expanded huntingtin target a multiplicity of key cellular factors. Mol Cell 63, 951-964. Bracher, A., Whitney, S.M., Hartl, F.U., and Hayer-Hartl, M. (2017). Biogenesis and metabolic maintenance of Rubisco. Ann Rev Plant Biol, Jan 11. doi: 10.1146/annurev-arplant-043015-111633. [Epub ahead of print].

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Bhat, J.Y., Milicic, G., Thieulin-Pardo, G., Bracher, A., Maxwell, A., Ciniawsky, S., Mueller-Cajar, O., Engen, J.R., Hartl, F.U., Wendler, P. and Hayer-Hartl, M. (2017). Mechanism of enzyme repair by the AAA+ chaperonbe Rubisco activase. Mol Cell 67, 744-756. Hartl, F.U. (2017). Protein misfolding diseases. Annu Rev Biochem 86, 21-26. Bäuerlein, F.J.B., Saha, I., Mishra, A., Kalemanov, M., Martínez-Sánchez, A., Klein, R., Dudanova, I., Hipp, M.S., Hartl, F.U.*, Baumeister, W.*, and Fernández-Busnadiego, R. (2017). In situ architecture and cellular interactions of polyQ inclu-sions. Cell 171, 179-187. Zheng, J., Yang, J., Choe, Y.J,. Hao, X., Cao, X., Zhao, Q., Zhang, Y., Franssens. V., Hartl, F.U., Nyström, T., Winderickx, J., and Liu, B. (2017). Role of the ribo-somal quality control machinery in nucleocytoplasmic translocation of polyQ-expanded huntingtin exon-1. Biochem Biophys Res Commun, Aug 30. pii: S0006-291X(17)31709-6. doi: 10.1016/j.bbrc.2017.08.126. [Epub ahead of print] Bhat, J,Y,, Thieulin-Pardo, G., Hartl, F.U., and Hayer-Hartl, M. (2017). Rubisco Activases: AAA+ Chaperones Adapted to Enzyme Repair. Front Mol Biosci, Apr 10;4:20. doi: 10.3389/ fmolb.2017.00020. eCollection 2017. Review Izawa, T., Park, S.-H., Zhao, L., Hartl, F. U., and Neupert, W. (2017). Cytosolic protein Vms1 links ribosome quality control to mitochondrial and cellular homeo-stasis. Cell 171, 890-903. Klaips, C., Jayaraj, G.G., and Hartl, F.U. (2017). Pathways of cellular proteostasis in aging and disease. J Cell Biol, Nov 10. pii: jcb.201709072. doi: 10.1083/jcb.201709072. [Epub ahead of print] Review. Hosp, F., Gutiérrez-Ángel, S., Schaefer, M.H., Cox, J., Meissner, F., Hipp, M.S., Hartl, F.U., Klein, R., Dudanova, I., and Mann, M. (2017). Spatiotemporal proteo-mic profiling of Huntington’s disease inclusions reveals widespread loss of protein function. Cell Reports, Nov 21;21(8):2291-2303. doi: 10.1016/j.celrep.2017.10.097. PMID: 29166617. Aigner, H., Wilson, R.H., Bracher, A., Calisse, L., , Bhat, J.Y., Hartl, F.U., and M. Hayer-Hartl, M. (2017). Plant Rubisco assembly in E. coli with five chloroplast chaperones including BSD2. Science 358, 1272-1278.

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Vincenz-Donnelly, L., Holthusen, H., Körner, R., Hansen, E.C., Presto, J., Johans-son, J., Sawarkar, R., Hartl, F.U, and Hipp, M.S. (2017). High capacity of the en-doplasmic reticulum to prevent secretion and aggregation of amyloidogenic pro-teins. EMBO J., Dec 15. pii: e201695841. doi: 10.15252/embj.201695841. [Epub ahead of print]. PMID: 29247078 Other Activities Chairman of Scientific Advisory Board, Proteostasis Therapeutics, Cambridge, USA, Member Scientific Advisory Board, Ernst Jung-Foundation, Member Selec-tion Committee for the Shaw Prize in Life Science and Medicine, Member Selec-tion Committee for the Heinrich Wieland Prize.

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Biochemistry Prof. Dr. rer. nat. Karl-Peter Hopfner Born 1968 in Kipfenberg/Bayern, 1988-1994 study of biology at Univ. Regensburg and Washington University, St. Louis (USA), 1997 PhD degree in the group of Prof. Dr. Robert Huber, Max-Planck-Institute for Biochemistry and TU Munich, 1997-1998 Postdoctoral fellow at MPI for Biochemistry/Roche Pharma, 1999-2001 Postdoctoral fellow in the group of Prof. Dr. John Tainer at The Scripps Research Institute, La Jolla, USA, 2001-2004 tenure track professor LMU Munich, 2005-2006 C3-professor LMU Munich, since 2007 W3-full professor LMU Munich, 2009 Director of the Department of Chemistry and Biochemistry, 2013-2015 Dean of Faculty, since 2015 Director of the Gene Center, since 2016 Director of the De-partment of Biochemistry Research Topics Structural Biology: Mechanisms of DNA-repair, the DNA damage response and remodeling ATPases in genome and cancer biology. Sensing and signaling of dam-aged and pathogenic nucleic acids in the innate immune system. Structural biology by cryo-electron microscopy and protein crystallography. Therapeutic antibody en-gineering. Honors, Awards, Memberships Gottfried Wilhelm Leibniz-Prize 2017 Member of the Max-Planck Society External scientific member of the Max-Planck-Institute for Biochemistry Member of the German Academy of Sciences Member of the European Molecular Biology Organization (EMBO) Member of the German Society for DNA Repair Member of International Max Planck Research School, Martinsried Extramural Research Funding Gottfried Wilhelm Leibniz Program of the DFG M4 Award European Research Council Advanced Grant “ATMMACHINE”

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Excellence Cluster Center for Integrated Protein Sciences Munich (DFG and the Federal Ministry of Education and Research) Graduate School Quantitative Biology Munich (DFG and the Federal Ministry of Education and Research) DFG HO2489/8 grant Collaborative Research Center 1054 (German Research Council) “T-cell plasticity” Collaborative Research Center 1064 (German Research Council) “Chromatin” Collaborative Research Center 1243 (German Research Council) “Cancer Evolu-tion” Student Research Training Group 1721 (German Research Council) “Integrated analysis of protein complexes and hybrid methods in genome biology” Student Research Training Group iTARGET (Elitenetzwerk Bayern) BioSysNet Senior Associated PI (Bavarian Ministry of Education and Science) Boehringer Ingelheim Fonds Publications – Scientific Papers Ahdash Z, Lau AM, Byrne RT, Lammens K, Stüetzer A, Urlaub H, Booth PJ, Reading E, Hopfner KP, Politis A. Mechanistic insight into the assembly of the He-rA-NurA helicase-nuclease DNA end resection complex. Nucleic Acids Res. 2017 Nov 16;45(20):12025-12038. Andreeva L, Hiller B, Kostrewa D, Lässig C, de Oliveira Mann CC, Jan Drexler D, Maiser A, Gaidt M, Leonhardt H, Hornung V, Hopfner KP. cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein-DNA ladders. Nature. 2017 Sep 21;549(7672):394-398. Lässig C, Hopfner KP. Discrimination of cytosolic self and non-self RNA by RIG-I-like receptors. J Biol Chem. 2017 Jun 2;292(22):9000-9009. Ponce LP, Fenn NC, Moritz N, Krupka C, Kozik JH, Lauber K, Subklewe M, Hopfner KP. SIRPα-antibody fusion proteins stimulate phagocytosis and promote elimination of acute myeloid leukemia cells. Oncotarget. 2017 Feb 14;8(7):11284-11301. Seeber A, Hegnauer AM, Hustedt N, Deshpande I, Poli J, Eglinger J, Pasero P, Gut H, Shinohara M, Hopfner KP, Shimada K, Gasser SM. RPA Mediates Recruitment of MRX to Forks and Double-Strand Breaks to Hold Sister Chromatids Together. Mol Cell. 2016 Dec 1;64(5):951-966

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Schiller CB, Braciak TA, Fenn NC, Seidel UJ, Roskopf CC, Wildenhain S, Honeg-ger A, Schubert IA, Schele A, Lämmermann K, Fey GH, Jacob U, Lang P, Hopfner KP, Oduncu FS. CD19-specific triplebody SPM-1 engages NK and γδ T cells for rapid and efficient lysis of malignant B-lymphoid cells. Oncotarget. 2016 Dec 13;7(50):83392-83408. Stahl E, Praetorius F, de Oliveira Mann CC, Hopfner KP, Dietz H. Impact of Het-erogeneity and Lattice Bond Strength on DNA Triangle Crystal Growth. ACS Nano. 2016 Sep 7. [Epub ahead of print] PubMed PMID: 27583560. de Oliveira Mann CC, Kiefersauer R, Witte G, Hopfner KP. Structural and bio-chemical characterization of the cell fate determining nucleotidyltransferase fold protein MAB21L1. Sci Rep. 2016 Jun 8;6:27498. Hartmann L, Dutta S, Opatz S, Vosberg S, Reiter K, Leubolt G, Metzeler KH, Her-old T, Bamopoulos SA, Bräundl K, Zellmeier E, Ksienzyk B, Konstandin NP, Schneider S, Hopfner KP, Graf A, Krebs S, Blum H, Middeke JM, Stölzel F, Thiede C, Wolf S, Bohlander SK, Preiss C, Chen-Wichmann L, Wichmann C, Sau-erland MC, Büchner T, Berdel WE, Wörmann BJ, Braess J, Hiddemann W, Spiek-ermann K, Greif PA. ZBTB7A mutations in acute myeloid leukaemia with t(8;21) translocation. Nat Commun. 2016 Jun 2;7:11733. Lässig C, Hopfner KP. RIG-I-Like Receptors: One STrEP Forward. Trends Micro-biol. 2016 Jul; 24(7):517-9. Hopfner KP. Invited review: Architectures and mechanisms of ATP binding cas-sette proteins. Biopolymers. 2016 Aug;105(8):492-504. Barford D, Hopfner KP. Editorial overview: Macromolecular machines and assem-blies. Curr Opin Struct Biol. 2016 Apr;37:vi-viii. Roskopf CC, Braciak TA, Fenn NC, Kobold S, Fey GH, Hopfner KP, Oduncu FS. Dual-targeting triplebody 33-3-19 mediates selective lysis of biphenotypic CD19+ CD33+ leukemia cells. Oncotarget. 2016 Apr 19;7(16):22579-89. Chatzopoulou EI, Roskopf CC, Sekhavati F, Braciak TA, Fenn NC, Hopfner KP, Oduncu FS, Fey GH, Rädler JO. Chip-based platform for dynamic analysis of NK cell cytolysis mediated by a triplebody. Analyst. 2016 Apr 7;141(7):2284-95.

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Lässig C, Matheisl S, Sparrer KM, de Oliveira Mann CC, Moldt M, Patel JR, Goldeck M, Hartmann G, García-Sastre A, Hornung V, Conzelmann KK, Beck-mann R, Hopfner KP. Correction: ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA. Elife. 2016 Mar 2;5. pii: e14954. Seifert FU, Lammens K, Stoehr G, Kessler B, Hopfner KP. Structural mechanism of ATP-dependent DNA binding and DNA end bridging by eukaryotic Rad50. EMBO J. 2016 Apr 1;35(7):759-72. Poli J, Gerhold CB, Tosi A, Hustedt N, Seeber A, Sack R, Herzog F, Pasero P, Shimada K, Hopfner KP, Gasser SM. Mec1, INO80, and the PAF1 complex coop-erate to limit transcription replication conflicts through RNAPII removal during replication stress. Genes Dev. 2016 Feb 1;30(3):337-54. Other Activities Co-founder and speaker of Graduate Research Training Program 1721 “Integrated analysis of protein complexes and hybrid methods in genome biology”, Co- or Ses-sion-Organizer: Keystone Symposium “Nucleic Acid Sensing” Dresden 2016, Co-organizer of the annual Ringberg-Meeting “Academia meets Industry, Industry meets Academia”. Grant reviewer for Deutsche Forschungsgemeinschaft, European Research Council; Cancer Research UK, EMBO, Welcome Trust, NSF (USA); FWF Austrian Science Fund; German-Israeli Research Foundation, Boehringer Ingelheim Fonds. Reviewer for Science, Nature, Nature Cell Biology, Nature Struc-tural and Molecular Biology, Cell, Molecular Cell, EMBO J, EMBO Reports, Cur-rent Biology, Journal of Molecular Biology, J. Clinical Investigation, Oncogene, J. Biol. Chem., Nucleic Acids Research, Structure. Board member CIPSM, steering committee member IMPRS-LS.

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Biochemistry Dr. Lucas T. Jae Born 1985 in Frankfurt/Main, 2005-2010 study of human biology at Univ. Marburg and MIT, Cambridge (USA), 2015 PhD degree in the group of Dr. Thijn R. Brum-melkamp (thesis advisor Dr. René Bernards), The Netherlands Cancer Institute, Amsterdam (Netherlands), 2015-2016 postdoctoral fellow at The Netherlands Can-cer Institute, Amsterdam (Netherlands), since November 2016 independent group leader at the Gene Center, LMU Munich. Research Topics Loss-of-function genetics in human cells, genome engineering, genetic interactions in human disease, organelle fidelity. Honors, Awards, Memberships Cord-Michael Becker Award Antoni van Leeuwenhoek Award Graduate School IMPRS-LS Graduate School Quantitative Biosciences Munich (QBM) German Society for Biochemistry and Molecular Biology (GBM) Extramural Research Funding Junior Researcher Fund, LMU Munich Excellence Cluster Center for Integrated Protein Sciences Munich (DFG and the Federal Ministry of Education and Research) Graduate School Quantitative Biosciences Munich (DFG and the Federal Ministry of Education and Research) Publications – Scientific Papers Maroofian R*, Riemersma M*, Jae LT, Zhianabed N, Willemsen MH, Wissink- Lindhout WM, Willemsen MA, de Brouwer APM, Mehrjardi MYV, Ashrafi MR, Kusters B, Kleefstra T, Jamshidi Y, Nasseri M, Pfundt R, Brummelkamp TR, Ab-

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baszadegan MR, Lefeber DJ, van Bokhoven H. B3GALNT2 mutations associated with non-syndromic autosomal recessive intellectual disability reveal a lack of gen-otype-phenotype associations in the muscular dystrophy- dystroglycanopathies. Genome Med. 2017 Dec 22;9(1):118. Raaben M, Jae LT, Herbert AS, Kuehne AI, Stubbs SH, Chou Y, Blomen VA, Dye JM, Whelan SP†, Brummelkamp TR†. NRP2 and CD63 are host factors for Lujo virus cell entry. Cell Host & Microbe. 2017 Nov 8;22(5):688–696. Mezzadra R*, Sun C*, Jae LT*, Gomez-Eerland R, de Vries E, Wu W, Logtenberg MEW, Slagter M, Rozeman EA, Hofland I, Broeks A, Horlings HM, Wessels L, Blank CU, Xiao Y, Heck AJR, Borst J, Brummelkamp TR†, and Schumacher TNM†. Identification of CMTM6 and CMTM4 as PD-L1 protein regulators. Na-ture. 2017 Sep 7;549(7670):106-110. Brockmann M*, Blomen VA*, Nieuwenhuis J, Stickel E, Raaben M, Bleijerveld OB, Altelaar AFM, Jae LT†, Brummelkamp TR†. Genetic wiring maps of single- cell protein states reveal an off-switch for GPCR signalling. Nature. 2017 Jun 8;546(7657):307-311. Pillay S*, Meyer NL*, Puschnik AS, Davulcu O, Diep J, Ishikawa Y, Jae LT, Wosen JE, Nagamine CM, Chapman MS, and Carette JE. An essential receptor for adeno-associated virus infection. Nature. 2016 Feb 4;530(7588):108-12. Baggen J*, Thibaut HJ*, Staring J, Jae LT, Liu Y, Guo H, Slager JJ, de Bruin JW, van Vliet ALW, Blomen VA, Overduin P, Sheng J, de Haan CAM, de Vries E, Meijer A, Rossmann MG, Brummelkamp TR, and van Kuppeveld FJM. Enterovi-rus D68 receptor requirements unveiled by haploid genetics. PNAS. 2016 Feb 2;113(5):1399-404.

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Biochemistry - Max Planck Institute of Biochemistry Prof. Dr. rer. nat. Dr. Dr. h.c. Matthias Mann Born in 1959 in Thuine, Lower Saxony. Degree in physics and mathematics at the Georg August University, Göttingen in 1988: Ph.D. in Chemical Engineering, Yale University, USA. 1989-92: Postdoctoral fellow and later Senior Scientist at the In-stitute of Molecular Biology at the University of Southern Denmark 1992 – 1998: Leader of the Protein and Peptide Group, European Molecular Biol-ogy Laboratory (EMBL), Heidelberg 1998-2007: Professor of Bioinformatics, In-stitute of Molecular Biology and Biochemistry, University of Southern Denmark, Director of the Centre of Experimental BioInformatics. Since 2005 Director at the Max Planck Institute of Biochemistry, Martinsried, Germany, und Honorary Pro-fessor at the Faculty of Chemistry and Pharmacy at the LMU, Munich. Since 2009 Chairman of the Proteomics Department of the Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Denmark. Research Topics Mass spectrometry based proteomics. Bioinformatics and systems biology. Signal transduction, phosphoproteomics, ubiquitilation. Large scale protein interaction studies. Clinical proteomics, especially of tissues and body fluids such as plasma. Metabolomics. Honours, Awards, Memberships 2017 Winner of the Lennart Philipson Award Elected member European Molecular Biology Organization (EMBO) Elected member Royal Danish Academy of Arts and Sciences Elected member of Leopoldina German National Academy of Sciences Member of Editorial Board Carcinogenesis Member of Editorial Board Cell Member of Editorial Board Cell Systems Member of Editorial Board Clinical Mass Spectrometry Member of Editorial Board Molecular and Cellular Proteomics

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Extramural Research Funding Bayer AG. Collaboration Project. Lysine acetylated enzyme targets and their regu-latory roles in human disease + crop efficiency. (2014-2017) BMBF. 01ZX1313G. E:AtheroSysMed Collaborative Project. (2013-2016) CIPSM Cluster of Excellence – subcontract. Administered from LMU (2012-2017) EMBO Individual Fellowships for Dr. Jeff Liu (2015-2017) EU 7th Framework Project Grant. EURO-Motor. G/A 259867. Collaborative pro-ject (2011-2016) EU ERC grant. ToPAG. Toxic Protein Aggregation in Neurodegeneration. ERC-2012-SyG 318987 (2013-2019) Michael J Fox Foundation for Parkinsons Research (1). LRRK2 Biology LEAPS Award. Combining mass spectrometry with genetic and pharmacological approach-es to discover and validate LRRK2 substrates (2012-2016) Michael J Fox Foundation for Parkinsons Research (2). Understanding regulation of Rabs by LRRK2. (2015-2018) Michael J Fox Foundation for Parkinsons Research (3). LRRK2 – RDI Project. (2013-2018) SyNergy Exzellenz Cluster. DFG. Munich Cluster for Systems Neurology. Admin-istrated from the LMU (2013-2018) Publications 2016 Aebersold R, Mann M. Mass-spectrometric exploration of proteome structure and function. Nature. 2016 Sep 14;537(7620):347-55 Bassani-Sternberg M, Bräunlein E, Klar R, Engleitner T, Sinitcyn P, Audehm S, Straub M, Weber J, Slotta-Huspenina J, Specht K, Martignoni ME, Werner A, Hein R, H Busch D, Peschel C, Rad R, Cox J, Mann M, Krackhardt AM. Direct identifi-cation of clinically relevant neoepitopes presented on native human melanoma tis-sue by mass spectrometry. Nat Commun. 2016 Nov 21;7:13404. Ding L, Paszkowski-Rogacz M, Winzi M, Chakraborty D, Theis M, Singh S, Ciotta G, Poser I, Roguev A, Chu WK, Choudhary C, Mann M, Stewart AF, Krogan N, Buchholz F. Systems Analyses Reveal Shared and Diverse Attributes of Oct4 Reg-ulation in Pluripotent Cells. Cell Syst. 2015 Aug 26;1(2):141-151.

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Di Stefano B, Collombet S, Jakobsen JS, Wierer M, Sardina JL, Lackner A, Stad-houders R, Segura-Morales C, Francesconi M, Limone F, Mann M, Porse B, Thieffry D, Graf T. C/EBPα creates elite cells for iPSC reprogramming by upregu-lating Klf4 and increasing the levels of Lsd1 and Brd4. Nat Cell Biol. 2016 Apr;18(4):371-81. Frey F, Sheahan T, Finkl K, Stoehr G, Mann M, Benda C, Müller J. Molecular ba-sis of PRC1 targeting to Polycomb response elements by PhoRC. Genes Dev. 2016 May 1;30(9):1116-27 Geiger R, Rieckmann JC, Wolf T, Basso C, Feng Y, Fuhrer T, Kogadeeva M, Picotti P, Meissner F, Mann M, Zamboni N, Sallusto F, Lanzavecchia A. L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Ac-tivity. Cell. 2016 Oct 20;167(3):829-842.e13. Geyer PE, Kulak NA, Pichler G, Holdt LM, Teupser D, Mann M. Plasma Proteome Profiling to Assess Human Health and Disease. Cell Syst. 2016 Mar 23;2(3):185-195 Geyer PE, Wewer Albrechtsen NJ, Tyanova S, Grassl N, Iepsen EW, Lundgren J, Madsbad S, Holst JJ, Torekov SS, Mann M. Proteomics reveals the effects of sus-tained weight loss on the human plasma proteome. Mol Syst Biol. 2016 Dec 22;12(12):901 Graham B, Marcais A, Dharmalingam G, Carroll T, Kanellopoulou C, Graumann J, Nesterova TB, Bermange A, Brazauskas P, Xella B, Kriaucionis S, Higgs DR, Brockdorff N, Mann M, Fisher AG, Merkenschlager M. MicroRNAs of the miR-290-295 Family Maintain Bivalency in Mouse Embryonic Stem Cells. Stem Cell Reports. 2016 May 10;6(5):635-42 Grassl N, Kulak NA, Pichler G, Geyer PE, Jung J, Schubert S, Sinitcyn P, Cox J, Mann M. Ultra-deep and quantitative saliva proteome reveals dynamics of the oral microbiome. Genome Med. 2016 Apr 21;8(1):44. Guerrera D, Shah J, Vasileva E, Sluysmans S, Mean I, Jond L, Poser I, Mann M, Hyman AA, Citi S. PLEKHA7 recruits PDZD11 to adherens junctions to stabilize nectins. J Biol Chem. 2016 Apr 4. [Epub ahead of print] Haahr P, Hoffmann S, Tollenaere MA, Ho T, Toledo LI, Mann M, Bekker-Jensen S, Räschle M, Mailand N. Activation of the ATR kinase by the RPA-binding pro-tein ETAA1. Nat Cell Biol. 2016 Nov;18(11):1196-1207.

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Hansen RK, Mund A, Poulsen SL, Sandoval M, Klement K, Tsouroula K, Tol-lenaere MA, Räschle M, Soria R, Offermanns S, Worzfeld T, Grosse R, Brandt DT, Rozell B, Mann M, Cole F, Soutoglou E, Goodarzi AA, Daniel JA, Mailand N, Bekker-Jensen S. SCAI promotes DNA double-strand break repair in distinct chromosomal contexts. Nat Cell Biol. 2016 Nov 7. [Epub ahead of print] Holdt LM, Stahringer A, Sass K, Pichler G, Kulak NA, Wilfert W, Kohlmaier A, Herbst A, Northoff BH, Nicolaou A, Gäbel G, Beutner F, Scholz M, Thiery J, Musunuru K, Krohn K, Mann M, Teupser D. Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans. Nat Com-mun. 2016 Aug 19;7:12429. Hoffmann S, Smedegaard S, Nakamura K, Mortuza GB, Räschle M, Ibañez de Opakua A, Oka Y, Feng Y, Blanco FJ, Mann M, Montoya G, Groth A, Bekker-Jensen S, Mailand N. TRAIP is a PCNA-binding ubiquitin ligase that protects ge-nome stability after replication stress. J Cell Biol. 2016 Jan 4;212(1):63-75 Holdt LM, Stahringer A, Sass K, Pichler G, Kulak NA, Wilfert W, Kohlmaier A, Herbst A, Northoff BH, Nicolaou A, Gäbel G, Beutner F, Scholz M, Thiery J, Musunuru K, Krohn K, Mann M, Teupser D. Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans. Nat Com-mun. 2016 Aug 19;7:12429. Hosp F, Lassowskat I, Santoro V, De Vleesschauwer D, Fliegner D, Redestig H, Mann M, Christian S, Hannah MA, Finkemeier I. Lysine acetylation in mitochon-dria: From inventory to function. Mitochondrion. 2016 Jul 28. pii: S1567-7249(16)30114-3 Iglesias-Gato D, Wikström P, Tyanova S, Lavallee C, Thysell E, Carlsson J, Häg-glöf C, Cox J, Andrén O, Stattin P, Egevad L, Widmark A, Bjartell A, Collins CC, Bergh A, Geiger T, Mann M, Flores-Morales A. The Proteome of Primary Prostate Cancer. Eur Urol. 2016 May;69(5):942-52. Keilhauer EC, Geyer PE, Mann M. HCD Fragmentation of Glycated Peptides. J Proteome Res. 2016 Aug 5;15(8):2881-90. Kim YE, Hosp F, Frottin F, Ge H, Mann M, Hayer-Hartl M, Hartl FU. Soluble Oli-gomers of PolyQ-Expanded Huntingtin Target a Multiplicity of Key Cellular Fac-tors. Mol Cell. 2016 Sep 15;63(6):951-64 Lund A, Bagger JI, Wewer Albrechtsen NJ, Christensen M, Grøndahl M, Hart-mann, B, Mathiesen ER, Hansen CP, Storkholm JH, van Hall G, Rehfeld JF, Horn-

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burg D, Meissner F, Mann M, Larsen S, Holst JJ, Vilsbøll T, Knop FK. Evidence of Extrapancreatic Glucagon Secretion in Man. Diabetes. 2016 Mar;65(3):585-97 Ma-Lauer Y, Carbajo-Lozoya J, Hein MY, Müller MA, Deng W, Lei J, Meyer B, Kusov Y, von Brunn B, Bairad DR, Hünten S, Drosten C, Hermeking H, Leonhardt H, Mann M, Hilgenfeld R, von Brunn A. p53 down-regulates SARS coronavirus replication and is targeted by the SARS-unique domain and PLpro via E3 ubiquitin ligase RCHY1. Proc Natl Acad Sci U S A. 2016 Aug 30;113(35):E5192-201 Mann M. Origins of mass spectrometry-based proteomics. Nat Rev Mol Cell Biol. 2016 Nov;17(11):678 Marakalala MJ, Raju RM, Sharma K, Zhang YJ, Eugenin EA, Prideaux B, Daudelin IB, Chen PY, Booty MG, Kim JH, Eum SY, Via LE, Behar SM, Barry CE 3rd, Mann M, Dartois V, Rubin EJ. Inflammatory signaling in human tubercu-losis granulomas is spatially organized. Nat Med. 2016 Apr 4. [Epub ahead of print Meier F, Beck S, Grassl N, Lubeck M, Park MA, Raether O, Mann M. Parallel Ac-cumulation-Serial Fragmentation (PASEF): Multiplying Sequencing Speed and Sensitivity by Synchronized Scans in a Trapped Ion Mobility Device. J Proteome Res. 2015 Dec 4;14(12):5378-87. Mischnik M, Sacco F, Cox J, Schneider HC, Schäfer M, Hendlich M, Crowther D, Mann M, Klabunde T. IKAP: A heuristic framework for inference of kinase activi-ties from Phosphoproteomics data. Bioinformatics. 2016 Feb 1;32(3):424-31. Neufeld-Cohen A, Robles MS, Aviram R, Manella G, Adamovich Y, Ladeuix B, Nir D, Rousso-Noori L, Kuperman Y, Golik M, Mann M, Asher G. Circadian con-trol of oscillations in mitochondrial rate-limiting enzymes and nutrient utilization by PERIOD proteins. Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):E1673-82 Robles MS, Humphrey SJ, Mann M. Phosphorylation Is a Central Mechanism for Circadian Control of Metabolism and Physiology. Cell Metab. 2016 Oct 29. pii: S1550-4131(16)30535-6. [Epub ahead of print] Sacco F, Silvestri A, Posca D, Pirrò S, Gherardini PF, Castagnoli L, Mann M, Cesareni G. Deep Proteomics of Breast Cancer Cells Reveals that Metformin Re-wires Signaling Networks Away from a Pro-growth State. Cell Syst. 2016 Mar 23;2(3):159-171 Sacco F, Humphrey SJ, Cox J, Mischnik M, Schulte A, Klabunde T, Schäfer M, Mann M. Glucose-regulated and drug-perturbed phosphoproteome reveals molecu-

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lar mechanisms controlling insulin secretion. Nat Commun. 2016 Nov 14;7:13250. Sarov M, Barz C, Jambor H, Hein MY, Schmied C, Suchold D, Stender B, Janosch S, Kj VV, Krishnan RT, Krishnamoorthy A, Ferreira IR, Ejsmont RK, Finkl K, Hasse S, Kämpfer P, Plewka N, Vinis E, Schloissnig S, Knust E, Hartenstein V, Mann M, Ramaswami M, VijayRaghavan K, Tomancak P, Schnorrer F. A genome-wide resource for the analysis of protein localisation in Drosophila. Elife. 2016 Feb 20;5 Schamberger AC, Schiller HB, Fernandez IE, Sterclova M, Heinzelmann K, Hen-nen E, Hatz R, Behr J, Vašáková M, Mann M, Eickelberg O, Staab-Weijnitz CA. Glutathione peroxidase 3 localizes to the epithelial lining fluid and the extracellular matrix in interstitial lung disease. Sci Rep. 2016 Jul 20;6:29952 Sivadasan R, Hornburg D, Drepper C, Frank N, Jablonka S, Hansel A, Lojewski X, Sterneckert J, Hermann A, Shaw PJ, Ince PG, Mann M, Meissner F, Sendtner M. C9ORF72 interaction with cofilin modulates actin dynamics in motor neurons. Nat Neurosci. 2016 Oct 10. [Epub ahead of print] Steger M, Tonelli F, Ito G, Davies P, Trost M, Vetter M, Wachter S, Lorentzen E, Duddy G, Wilson S, Baptista MA, Fiske BK, Fell MJ, Morrow JA, Reith AD, Alessi DR, Mann M. Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases. Elife. 2016 Jan 29;5 Temu T, Mann M, Räschle M, Cox J. Homology-driven assembly of NOn-redundant protEin sequence sets (NOmESS) for mass spectrometry. Bioinformat-ics. 2016 May 1;32(9):1417-9. Tyanova S, Albrechtsen R, Kronqvist P, Cox J, Mann M, Geiger T. Proteomic maps of breast cancer subtypes. Nat Commun. 2016 Jan 4;7:10259. Tyanova S, Temu T, Sinitcyn P, Carlson A, Hein MY, Geiger T, Mann M, Cox J.The Perseus computational platform for comprehensive analysis of (prote)omics data. Nat Methods. 2016 Sep;13(9):731-40 Wewer Albrechtsen NJ, Hornburg D, Albrechtsen R, Svendsen B, Toräng S, Jepsen SL, Kuhre RE, Hansen M, Janus C, Floyd A, Lund A, Vilsbøll T, Knop FK, Vestergaard H, Deacon CF, Meissner F, Mann M, Holst JJ, Hartmann B. Oxynto-modulin Identified as a Marker of Type 2 Diabetes and Gastric Bypass Surgery by Mass-spectrometry Based Profiling of Human Plasma. EBioMedicine. 2016 May; Epub 2016 Mar 31

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Wierer M, Mann M. Proteomics to study DNA-bound and chromatin-associated gene regulatory complexes. Hum Mol Genet. 2016 Jul 11. pii: ddw208. Wiśniewski JR, Mann M. A Proteomics Approach to the Protein Normalization Problem: Selection of Unvarying Proteins for MS-Based Proteomics and Western Blotting. J Proteome Res. 2016 Jul 1;15(7):2321-6. Woerner AC, Frottin F, Hornburg D, Feng LR, Meissner F, Patra M, Tatzelt J, Mann M, Winklhofer KF, Hartl FU, Hipp MS. Cytoplasmic protein aggregates in-terfere with nucleocytoplasmic transport of protein and RNA. Science. 2016 Jan 8;351(6269):173-6. 2017 Dewar JM, Low E, Mann M, Räschle M, Walter JC. CRL2(Lrr1) promotes unload-ing of the vertebrate replisome from chromatin during replication termination. Genes Dev. 2017 Feb 1;31(3):275-290. Doll S, Dreßen M, Geyer PE, Itzhak DN, Braun C, Doppler SA, Meier F, Deutsch MA, Lahm H, Lange R, Krane M, Mann M. Region and cell-type resolved quanti-tative proteomic map of the human heart. Nat Commun. 2017 Nov 13;8(1):1469. Geyer PE, Holdt LM, Teupser D, Mann M. Revisiting biomarker discovery by plasma proteomics. Mol Syst Biol. 2017 Sep 26;13(9):942. Hartl M, Füßl M, Boersema PJ, Jost JO, Kramer K, Bakirbas A, Sindlinger J, Plöchinger M, Leister D, Uhrig G, Moorhead GB, Cox J, Salvucci ME, Schwarzer D, Mann M, Finkemeier I. Lysine acetylome profiling uncovers novel histone deacetylase substrate proteins in Arabidopsis. Mol Syst Biol. 2017 Oct 23;13(10):949 Hosp F, Mann M. A Primer on Concepts and Applications of Proteomics in Neuro-science. Neuron. 2017 Nov 1;96(3):558-571. Hosp F, Gutiérrez-Ángel S, Schaefer MH, Cox J, Meissner F, Hipp MS, Hartl FU, Klein R, Dudanova I, Mann M. Spatiotemporal Proteomic Profiling of Huntington's Disease Inclusions Reveals Widespread Loss of Protein Function. Cell Rep. 2017 Nov 21;21(8):2291-2303. Kälin S, Becker M, Ott VB, Serr I, Hosp F, Mollah MMH, Keipert S, Lamp D, Rohner-Jeanrenaud F, Flynn VK, Scherm MG, Nascimento LFR, Gerlach K, Popp V, Dietzen S, Bopp T, Krishnamurthy P, Kaplan MH, Serrano M, Woods SC, Tri-

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pal P, Palmisano R, Jastroch M, Blüher M, Wolfrum C, Weigmann B, Ziegler AG, Mann M, Tschöp MH, Daniel C. A Stat6/Pten Axis Links Regulatory T Cells with Adipose Tissue Function. Cell Metab. 2017 Sep 5;26(3):475-492.e7. Kappei D, Scheibe M, Paszkowski-Rogacz M, Bluhm A, Gossmann TI, Dietz S, Dejung M, Herlyn H, Buchholz F, Mann M, Butter F. Phylointeractomics recon-structs functional evolution of protein binding. Nat Commun. 2017 Feb 8;8:14334. Kulak NA, Geyer PE, Mann M. Loss-less nano-fractionator for high sensitivity, high coverage proteomics. Mol Cell Proteomics. 2017 Jan 26. pii: mcp.O116.065136 Lassowskat I, Hartl M, Hosp F, Boersema PJ, Mann M, Finkemeier I. Dimethyl-Labeling-Based Quantification of the Lysine Acetylome and Proteome of Plants. Methods Mol Biol. 2017;1653:65-81. Lis P, Burel S, Steger M, Mann M, Brown F, Diez F, Tonelli F, Holton JL, Ho PW, Ho SL, Chou MY, Polinski NK, Martinez TN, Davies P, Alessi DR. Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the LRRK2 Parkinson's disease kinase. Biochem J. 2018 Jan 2;475(1):1-22 Murgia M, Toniolo L, Nagaraj N, Ciciliot S, Vindigni V, Schiaffino S, Reggiani C, Mann M. Single Muscle Fiber Proteomics Reveals Fiber-Type-Specific Features of Human Muscle Aging. Cell Rep. 2017 Jun 13;19(11):2396-2409. Pünzeler S, Link S, Wagner G, Keilhauer EC, Kronbeck N, Spitzer RM, Leidescher S, Markaki Y, Mentele E, Regnard C, Schneider K, Takahashi D, Kusakabe M, Vardabasso C, Zink LM, Straub T, Bernstein E, Harata M, Leonhardt H, Mann M, Rupp RA, Hake SB. Multivalent binding of PWWP2A to H2A.Z regulates mitosis and neural crest differentiation. EMBO J. 2017 Aug 1;36(15):2263-2279. Rieckmann JC, Geiger R, Hornburg D, Wolf T, Kveler K, Jarrossay D, Sallusto F, Shen-Orr SS, Lanzavecchia A, Mann M, Meissner F. Social network architecture of human immune cells unveiled by quantitative proteomics. Nat Immunol. 2017 May;18(5):583-593. Schiller HB, Mayr CH, Leuschner G, Strunz M, Staab-Weijnitz C, Preisendörfer S, Eckes B, Moinzadeh P, Krieg T, Schwartz DA, Hatz RA, Behr J, Mann M, Eickel-berg O. Deep Proteome Profiling Reveals Common Prevalence of MZB1-Positive Plasma B Cells in Human Lung and Skin Fibrosis. Am J Respir Crit Care Med. 2017 Nov 15;196(10):1298-1310.

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Steger M, Diez F, Dhekne HS, Lis P, Nirujogi RS, Karayel O, Tonelli F, Martinez TN, Lorentzen E, Pfeffer SR, Alessi DR, Mann M. Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to cili-ogenesis. Elife. 2017 Nov 10;6. pii: e31012. doi: 10.7554/eLife.31012 Tain LS, Sehlke R, Jain C, Chokkalingam M, Nagaraj N, Essers P, Rassner M, Grönke S, Froelich J, Dieterich C, Mann M, Alic N, Beyer A, Partridge L. A prote-omic atlas of insulin signalling reveals tissue-specific mechanisms of longevity as-surance. Mol Syst Biol. 2017 Sep 15;13(9):939. Walther DM, Kasturi P, Zheng M, Pinkert S, Vecchi G, Ciryam P, Morimoto RI, Dobson CM, Vendruscolo M, Mann M, Hartl FU. Widespread Proteome Remodel-ing and Aggregation in Aging C. elegans. Cell. 2017 Feb 23;168(5):944. Wewer Albrechtsen NJ, Kuhre RE, Hornburg D, Jensen CZ, Hornum M, Dirksen C, Svane M, Gasbjerg LS, Jørgensen NB, Gabe MN, Balk-Møller E, Albrechtsen R, Winther-Sørensen M, Galsgaard KD, Meissner F, Jorsal T, Lund A, Vilsbøll T, Eliasen R, Bojsen-Møller KN, Idorn T, Deacon CF, Knop FK, Rosenkilde MM, Hartmann B, Feldt-Rasmussen B, Mann M, Madsbad S, Holst JJ. Circulating Glu-cagon 1-61 Regulates Blood Glucose by Increasing Insulin Secretion and Hepatic Glucose Production. Cell Rep. 2017 Nov 7;21(6):1452-1460. Wierer M, Prestel M, Schiller H, Yan G, Schaab C, Azghandi S, Werner J, Kessler T, Malik R, Murgia M, Aherrahrou Z, Schunkert H, Dichgans M, Mann M. Com-partment-resolved Proteomic Analysis of Mouse Aorta during Atherosclerotic Plaque Formation Reveals Osteoclast-specific Protein Expression. Mol Cell Prote-omics. 2017 Dec 4. [Epub ahead of print] Windeløv JA, Wewer Albrechtsen NJ, Kuhre RE, Jepsen SL, Hornburg D, Peder-sen J, Jensen EP, Galsgaard KD, Winther-Sørensen M, Ørgaard A, Deacon CF, Mann M, Kissow H, Hartmann B, Holst JJ. Why is it so difficult to measure gluca-gon-like peptide-1 in a mouse? Diabetologia. 2017 Oct;60(10):2066-2075. Zink LM, Delbarre E, Eberl HC, Keilhauer EC, Bönisch C, Pünzeler S, Bartkuhn M, Collas P, Mann M, Hake SB. H3.Y discriminates between HIRA and DAXX chaperone complexes and reveals unexpected insights into human DAXX-H3.3-H4 binding and deposition requirements. Nucleic Acids Res. 2017 Jun 2;45(10):5691-5706.

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Biochemistry – Helmholtz Zentrum München/Neuherberg Priv.-Doz. Dr. rer. nat. Anton Schäffner Born 1959 in Steinhöring/Bayern, 1978-1984 studies of Chemistry and Biochemis-try at LMU München, 1988 dissertation with Guido Hartmann (Autocatalysed af-finity labeling of DNA-dependent RNA polymerases), 1988-1990 Postdoctoral fel-low with Jen Sheen, Massachusetts General Hospital, Harvard University, Boston, USA (Regulation of gene expression in maize), 1990-1997 Research group leader, Institute of Biochemistry/ Genecenter, LMU München (discovery of plant aqua-porins), 1996 Habilitation, 1997 Appointment as Privatdozent, since 1997 Research group leader Molecular Plant Physiology at the Institute of Biochemical Plant Pa-thology, Helmholtz Zentrum München. Research Topics Plant membrane proteins: aquaporins in lateral root development and environmen-tal interactions, regulation of aquaporins at protein level. Plant pathogen defense: regulation of defense pathways, signaling, small-molecule glycosyltransferases, targeted and non-targeted metabolomics. Plant cytoskeleton and coordinated cell expansion. Arabidopsis thaliana and related crop plants. Plant phenotyping, sys-tems biology, modeling, combined abiotic stress response to drought and heat, om-ics data integration. Honors, Awards, Memberships Member of the German Chemical Society (GDCh) Member of the American Society of Plant Biologists Member of the Society of Experimental Biology Member of the German Botanical Society (DBG) Member of the Gesellschaft für Biochemie und Molekularbiologie Extramural Research Funding Fellowships from DAAD (2017-2018), CAPES (Brazil, 2017-2021) and CSC (Chi-na Scholarship Council, 2016-2020) to graduate students

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Publications – Scientific Papers Das M, Haberer G, Laha SD, Ghosh TC, Schäffner AR (2016) Expression pattern similarities support the prediction of orthologs retaining common functions after gene duplication events. Plant Physiol. 171, 2343-2357 Schäffner AR (2016) Flavonoid biosynthesis and Arabidopsis genetics: more good music. J. Exp. Bot. 67, 1203-1204 Georgii E, Jin M, Zhao J, Kanawati B, Schmitt-Kopplin P, Albert A, Winkler JB, Schäffner AR (2017) Relationships between drought, heat and air humidity re-sponses revealed by transcriptome-metabolome co-analysis. BMC Plant Biol. 17, 120 Other Activities Advisory Board of Journal of Experimental Botany, Co-editor Frontiers in Plant Science – Section Plant Metabolism and Chemodiversity. Grant reviewer for Deutsche Forschungsgemeinschaft. Reviewer for Journal of Biological Chemistry; Nature Communications; Scientific Reports; Development; FEBS Letters; Plant Physiology; The Plant Journal; Journal of Experimental Botany; Plant Molecular Biology; Frontiers in Plant Science; Plant Biology; Plant, Cell and Environment; International Journal of Molecular Sciences; Protoplasma; Journal of Plant Physiology; Plantae; BMC Plant Biology

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Biochemistry Prof. Dr. rer. nat. Julian Stingele Born 1984 in Filderstadt, 2004-2010 study of biology at University of Konstanz, 2015 PhD degree in the group of Prof. Dr. Stefan Jentsch, Max-Planck-Institute for Biochemistry, 2014-2017 postdoctoral fellow at the Francis Crick Institute, Lon-don, UK, in the group of Prof. Dr. Simon Boulton, since 2017 tenure-track profes-sor at the Gene Center, LMU Munich. Research Topics Mechanisms of genome maintenance, sources of endogenous DNA damage, DNA-protein crosslink repair, molecular mechanism of DNA-dependent proteases. Honors, Awards, Memberships Member of the Biochemical Society EMBO Long-Term Fellowship Extramural Research Funding Excellence Cluster Center for Integrated Protein Sciences Munich (DFG and the Federal Ministry of Education and Research) Nachwuchsförderungsfond LMUexcellent Publications – Scientific Papers Stingele, J., Bellelli, R., and Boulton, S.J. (2017), Mechanisms of DNA-protein crosslink repair. Nat. Rev. Mol. Cell Biol. 18(9):563-573. Stingele, J., Bellelli, R., Alte, F., Hewitt, G., Sarek, G., Maslen, S.L., Tsutakawa, S.E., Borg, A., Kjaer, S., Tainer, J.A., Skehel, J.M., Groll, M. and Boulton, S.J. (2016), Mechanism and regulation of DNA-protein crosslink repair by the DNA-dependent metalloprotease SPRTN. Mol. Cell, 64(4):688-703.

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Biochemistry - Max Planck Institute of Psychiatry Apl. Prof. Dr. rer. nat. Christoph W. Turck 1974-1981 Diploma Chemistry RWTH Aachen, 1983 Dr. rer. nat. Macromolecular Chemistry with Prof. Dr. Dr. mult. h.c. Helmut Zahn (Peptide Synthesis with Cate-chol-halfester-Derivatives at Elevated Temperatures), 1983-1986 Postdoc with Dr. David R. Webb, Roche Institute of Molecular Biology, Department of Cell Biolo-gy, Nutley, NJ, USA (Characterization of immunomodulatory T cell proteins), 1986-1988 Instructor, 1988-1994 Assistant Professor, 1994-2000 Associate Profes-sor, 2000-2002 Professor, University of California, San Francisco, Howard Hughes Medical Institute, Department of Medicine, Cardiovascular Research Institute, San Francisco, CA, USA (Growth factor receptor signal transduction, Director of Pro-tein Structure Laboratory), since 2002 Research Group Leader, Proteomics and Bi-omarkers, Max Planck Institute of Psychiatry, Department of Translational Re-search in Psychiatry, Munich, since 2003 Adj. Professor, Chemistry and Pharmacy, LMU Munich, since 2005 Faculty, International Max Planck Research School for Molecular and Cellular Life Sciences, Munich, since 2009 Munich Center for Neu-rosciences, LMU Munich, since 2009 Faculty, Graduate School of Systemic Neu-rosciences, LMU Munich, since 2015 Faculty, International Max Planck Research School for Translational Psychiatry, Munich. Research Topics Biomarker identification and validation, patient stratification, mouse models of dis-ease, proteomics technologies, protein turnover, metabolomics. Honors, Awards, Memberships American Society for Mass Spectrometry Association of Biomolecular Research Facilities American College of Neuropsychopharmacology Molecular Psychiatry Association US HUPO German Chemical Society German Proteome Society

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Extramural Research Funding ERA-NET NEURON Mental Disorders BMBF, OptiMD BMBF, KMU Innovativ NIH Common Fund, Collaborative Activities to Promote Metabolomics Research Publications – Scientific Papers Park DI, Dournes C, Sillaber I, Ising M, Asara JM, Webhofer C, Filiou MD, Müller MB, Turck CW. (2017) Delineation of molecular pathway activities of the chronic antidepressant treatment response suggests important roles for glutamatergic and ubiquitin-proteasome systems. Transl Psychiatry 7(4):e1078 [Pubmed]. Weckmann K, Deery MJ, Howard JA, Feret R, Asara JM, Dethloff F, Filiou MD, Iannace J, Labermaier C, Maccarrone G, Webhofer C, Teplytska L, Lilley K, Mül-ler MB, Turck CW. (2017) Ketamine's antidepressant effect is mediated by energy metabolism and antioxidant defense system. Sci Rep 17;7:15788. [Pubmed] Turck CW, Guest PC, Maccarrone G, Ising M, Kloiber S, Lucae S, Holsboer F, Martins-de-Souza D. (2017) Proteomic Differences in Blood Plasma Associated with Antidepressant Treatment Response. Front Mol Neurosci 10:272. [Pubmed] Maccarrone G, Bonfiglio JJ, Silberstein S, Turck CW, Martins-de-Souza D. (2017) Characterization of a Protein Interactome by Co-Immunoprecipitation and Shotgun Mass Spectrometry. Methods Mol Biol 1546:223-234. [Pubmed] Café-Mendes CC, Ferro ES, Torrão AS, Crunfli F, Rioli V, Schmitt A, Falkai P, Britto LR, Turck CW, Martins-de-Souza D. (2017) Peptidomic analysis of the ante-rior temporal lobe and corpus callosum from schizophrenia patients. J Proteomics 151:97-105. [Pubmed] Kao CY, He Z, Zannas AS, Hahn O, Kühne C, Reichel JM, Binder EB, Wotjak CT, Khaitovich P, Turck CW. (2016) Fluoxetine treatment prevents the inflammatory response in a mouse model of posttraumatic stress disorder. J Psychiatr Res 76:74-83. [Pubmed] Cassoli JS, Iwata K, Steiner J, Guest PC, Turck CW, Nascimento JM, Martins-de-Souza D. (2016) Effect of MK-801 and Clozapine on the Proteome of Cultured Human Oligodendrocytes. Front Cell Neurosci 10:52 [Pubmed]

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Lopes S, Teplytska L, Vaz-Silva J, Dioli C, Trindade R, Morais M, Webhofer C, Maccarrone G, Almeida OF, Turck CW, Sousa N, Sotiropoulos I, Filiou MD. (2016) Tau Deletion Prevents Stress-Induced Dendritic Atrophy in Prefrontal Cor-tex: Role of Synaptic Mitochondria. Cereb Cortex 27:2580-2591. [Pubmed] Su SY, Hogrefe-Phi CE, Asara JM, Turck CW, Golub MS. (2016) Peripheral fibro-blast metabolic pathway alterations in juvenile rhesus monkeys undergoing long-term fluoxetine administration. Eur Neuropsychopharmacol 26:1110-1118. [Pub-med] Kao C-Y, He Z, Henes K, Asara JM, Webhofer, C, Filiou MD, Khaitovich P, Wot-jak CT, Turck CW. (2016) Fluoxetine Treatment Rescues Energy Metabolism Pathway Alterations in a Posttraumatic Stress Disorder Mouse Model. Mol Neuro-psychiatry 2:46-59. [Pubmed] Turck CW, Webhofer C, Nussbaumer M, Teplytska L, Chen A, Maccarrone G, Fil-iou MD. (2016) Stable isotope metabolic labeling suggests differential turnover of the DPYSL protein family. Proteomics Clin Appl 10:1269-1272. [Pubmed] Maccarrone G, Nischwitz S, Deininger SO, Hornung J, K FB, Stadelmann C, Turck CW, Weber F. (2016) MALDI imaging mass spectrometry analysis-A new ap-proach for protein mapping in multiple sclerosis brain lesions. J Chromatogr B An-alyt Technol Biomed Life Sci S1570-0232:30452-30454. [Pubmed] Inda C, Dos Santos Claro PA, Bonfiglio JJ, Senin SA, Maccarrone G, Turck CW, Silberstein S. (2016) Different cAMP sources are critically involved in G protein-coupled receptor CRHR1 signaling. J Cell Biol 214:181-195. [Pubmed] Park DI, Dournes C, Sillaber I, Uhr M, Asara JM, Gassen NC, Rein T, Ising M, Webhofer C, Filiou MD, Mller MB, Turck CW. (2016) Purine and pyrimidine me-tabolism: Convergent evidence on chronic antidepressant treatment response in mice and humans. Sci Rep 6:35317. [Pubmed] Other Activities fNIH Biomarkers Consortium, Neuroscience Steering Committee International Expert Panel, National Medical Research Council, Singapore Chair, ABRF Metabolomics Research Group Biomarkers in Medicine, Editorial Board BMC Neuroscience, Associate Editor Molecular and Cellular Proteomics, Editorial Board

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Biochemistry Dr. rer. nat. Daniel N. Wilson Born 1971 in London, UK, 1989-1991 Biochemistry Degree, University of Victo-ria, Wellington, New Zealand. 1992 Honours thesis (first class) in the group of Prof. Andrew Dowsett, Victoria University of Wellington, New Zealand. 1993-1999 PhD in the group of Prof. Dr. Warren P. Tate, Department of Biochemistry, University of Otago, Dunedin, New Zealand. 2000-2001 Regional Manager, Bio-gene Ltd, UK. 2001-2002 Alexander von Humboldt Fellow in the group of Prof Knud Nierhaus (AG Ribosomen) at the Max-Planck-Institute for Molecular Genetics, Berlin. 2003-2006 Postdoctoral research assistant in the ribosome crystal-lography group (Dr Paola Fucini/Prof Ada Yonath) at the Max-Planck-Institute for Molecular Genetics, Berlin. Since 2007 Independent group leader, Gene Center and Department of Biochemistry, University of Munich, Germany. Research Topics Ribosome-targeting antibiotics and resistance mechanisms: Structural and bio-chemical characterization of small molecule interaction with the ribosome. Cryo-electron microscopic analysis of drug-dependent and polypeptide-mediated ribo-some stalling. Elucidation of function of non-canonical translation factors that in-teract and regulate translation. Identification of new targets within the cell for the development of novel antivirulence antimicrobial agents. Honors, Awards, Memberships Alexander von Humboldt fellow EMBO Young Investigator Associate member of the Faculty of 1000 (F1000) Associate member, center for integrated protein science, Munich (CiPSM) Member of the RNA Society Extramural Research Funding National Institute of Health (NIH Subaward 201REY320) Excellence Cluster Center for Integrated Protein Sciences Munich (DFG and the Federal Ministry of Education and Research)

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Forschergruppe (FOR1805, DFG WI3285-2/2) DFG (WI3285-3/1, WI3285-4/1, WI3285-1) SPP 1879 EMBO Young investigator award Publications – Scientific Papers Huter P, Arenz S, Bock LV, Graf M, Frister JO, Heuer A, Peil L, Starosta AL, Wohlgemuth I, Peske F, Nováček J, Berninghausen O, Grubmüller H, Tenson T, Beckmann R, Rodnina MV, Vaiana AC, Wilson DN. Structural Basis for Polypro-line-Mediated Ribosome Stalling and Rescue by the Translation Elongation Factor EF-P. Mol Cell. 2017 Nov 2;68(3):515-527 Leoni G, De Poli A, Mardirossian M, Gambato S, Florian F, Venier P, Wilson DN, Tossi A, Pallavicini A, Gerdol M. Myticalins: A Novel Multigenic Family of Line-ar, Cationic Antimicrobial Peptides from Marine Mussels (Mytilus spp.). Mar Drugs. 2017 Aug 22;15(8). Florin T, Maracci C, Graf M, Karki P, Klepacki D, Berninghausen O, Beckmann R, Vázquez-Laslop N, Wilson DN, Rodnina MV, Mankin AS. An antimicrobial pep-tide that inhibits translation by trapping release factors on the ribosome. Nat Struct Mol Biol. 2017 Sep;24(9):752-757. Huter P, Müller C, Arenz S, Beckert B, Wilson DN. Structural Basis for Ribosome Rescue in Bacteria. Trends Biochem Sci. 2017 Aug;42(8):669-680. Su T, Cheng J, Sohmen D, Hedman R, Berninghausen O, von Heijne G, Wilson DN, Beckmann R. The force-sensing peptide VemP employs extreme compaction and secondary structure formation to induce ribosomal stalling. Elife. 2017 May 30;6. pii: e25642. Graf M, Mardirossian M, Nguyen F, Seefeldt AC, Guichard G, Scocchi M, Innis CA, Wilson DN. Proline-rich antimicrobial peptides targeting protein synthesis. Nat Prod Rep. 2017 Jul 1;34(7):702-711. Beckert B, Abdelshahid M, Schäfer H, Steinchen W, Arenz S, Berninghausen O, Beckmann R, Bange G, Turgay K, Wilson DN. Structure of the Bacillus subtilis hibernating 100S ribosome reveals the basis for 70S dimerization. EMBO J. 2017 Jul 14;36(14):2061-2072.

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Graf M, Arenz S, Huter P, Dönhöfer A, Novácek J, Wilson DN. Cryo-EM structure of the spinach chloroplast ribosome reveals the location of plastid-specific riboso-mal proteins and extensions. Nucleic Acids Res. 2017 Mar 17;45(5):2887-2896. Huter P, Müller C, Beckert B, Arenz S, Berninghausen O, Beckmann R, Wilson DN. Structural basis for ArfA-RF2-mediated translation termination on mRNAs lacking stop codons. Nature. 2017 Jan 26;541(7638):546-549. Prunetti L, Graf M, Blaby IK, Peil L, Makkay AM, Starosta AL, Papke RT, Oshi-ma T, Wilson DN, de Crécy-Lagard V. Deciphering the Translation Initiation Fac-tor 5A Modification Pathway in Halophilic Archaea. Archaea. 2016 Dec 8;2016:7316725. Wilson DN, Clark PL. Climbing to the peak of nascent-chain knowledge. Nat Struct Mol Biol. 2016 Nov 4;23(11):949-951. Arenz S, Wilson DN. Bacterial Protein Synthesis as a Target for Antibiotic Inhibi-tion. Cold Spring Harb Perspect Med. 2016 Sep 1;6(9) Arenz S, Bock LV, Graf M, Innis CA, Beckmann R, Grubmüller H, Vaiana AC, Wilson DN. A combined cryo-EM and molecular dynamics approach reveals the mechanism of ErmBL-mediated translation arrest. Nat Commun. 2016 Jul 6;7:12026. Arenz S, Juette MF, Graf M, Nguyen F, Huter P, Polikanov YS, Blanchard SC, Wilson DN. Structures of the orthosomycin antibiotics avilamycin and evernimicin in complex with the bacterial 70S ribosome. Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):7527-32 Wilson DN, Spahn CM. Knud Hermann Nierhaus 1941-2016. Nat Struct Mol Biol. 2016 Jun 7;23(6):503-4. Arenz S, Abdelshahid M, Sohmen D, Payoe R, Starosta AL, Berninghausen O, Hauryliuk V, Beckmann R, Wilson DN. The stringent factor RelA adopts an open conformation on the ribosome to stimulate ppGpp synthesis. Nucleic Acids Res. 2016 Jul 27;44(13):6471-81. Wilson DN. The ABC of Ribosome-Related Antibiotic Resistance. MBio. 2016 May 3;7(3). Wilson DN, Arenz S, Beckmann R. Translation regulation via nascent polypeptide-mediated ribosome stalling. Curr Opin Struct Biol. 2016 Apr;37:123-33.

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Seefeldt AC, Graf M, Pérébaskine N, Nguyen F, Arenz S, Mardirossian M, Scocchi M, Wilson DN, Innis CA. Structure of the mammalian antimicrobial peptide Bac7(1-16) bound within the exit tunnel of a bacterial ribosome. Nucleic Acids Res. 2016 Mar 18;44(5):2429-38. Schmidt C, Becker T, Heuer A, Braunger K, Shanmuganathan V, Pech M, Berninghausen O, Wilson DN, Beckmann R. Structure of the hypusinylated eukar-yotic translation factor eIF-5A bound to the ribosome. Nucleic Acids Res. 2016 Feb 29;44(4):1944-51. Arenz S, Wilson DN. Blast from the Past: Reassessing Forgotten Translation Inhib-itors, Antibiotic Selectivity, and Resistance Mechanisms to Aid Drug Development. Mol Cell. 2016 Jan 7;61(1):3-14. Lassak J, Wilson DN, Jung K. Stall no more at polyproline stretches with the trans-lation elongation factors EF-P and IF-5A. Mol Microbiol. 2016 Jan;99(2):219-35. Other Activities Grant reviewer for Deutsche Forschungsgemeinschaft (DFG, Deutschland), Na-tional Science Foundation (NSF, USA), Netherlands Organization for Scientific Research (NWO, Niederlande), Marsden Fund (Neuseeland), European Molecular Biology Organizations (EMBO, Europe), Research Corporation for Science Ad-vancement (USA), French evaluation agency for research and higher education (AERES), The French Muscular Dystrophy Association (AFM), French National Research Agency (ANR), Estonian Research Council and the Medical Research Scotland (MRS). Reviewer for Nature, Science, Cell, Molecular Cell, Nature Structural and Molecu-lar Biology, Proceedings of the National Academy of Sciences USA, Antimicrobial Agents and Chemotherapy, Nucleic Acids Research, Biochemie, Journal Biological Chemistry, Journal of Molecular Biology, Nature Communications, Cell Reports, Trends in Biological Sciences, ChemBioChem, PLoS ONE, Biochemistry, Molecu-lar Microbiology, BBA – Gene Regulatory Mechanisms, FEBS Letters, Journal of Bacteriology, Biological Chemistry, RNA Biology, Genes and Development, ACS Chemical Biology, and EMBO J.

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Organic Chemistry Prof. Dr. rer. nat. Thomas Carell Born 1966 in Herford/NRW, 1985-1990 study of chemistry at Univ. Münster and Heidelberg. In 1993 he obtained his doctorate with Prof. H. A. Staab at the Max-Planck-Institue of Medical Research. After postdoctoral training with Prof. J. Re-bek at MIT (Cambridge, USA) in 1993-1995, he moved to the ETH Zürich (Swit-zerland) into the group of Prof. F. Diederich to start independent research. He ob-tained his habilitation in 1999. In 2000 he accepted a full professor position for Or-ganic Chemisty at the Philipps-Universität in Marburg (Germany). And in 2004 he finally moved as a full professor for Organic Chemistry to the Ludwig-Maximilians-Universität (LMU) in Munich (Germany). Research Topics Chemistry of nucleic acids and amino acids, investitgation of biosynthetic path-ways, chemical manipulation of cellular functions (synthetic biology), investigation of DNA processes and epigenetic reprogramming, structural biology of DNA repair proteins, chemistry of natural products and synthesis of anticancer compounds. Honors, Awards, Memberships Member of the Kuratorium Volkswagenstiftung Member of the Kuratorium of the Fonds der Chemischen Industry Member of the Kuratorium Angewandte Chemie Member of the National Academy Leopoldina Member of the Berlin-Brandenburgische Academy of Arts and Sciences Extramural Research Funding Collaborative Research Center 749 (German Research Council) “Dynamics and Intermediates of Molecular Transformations” Collaborative Research Center 1032 (German Research Council) “Nanoagents for the spatio-temporal control of molecular and cellular reactions” EU-Projekt CLICKGENE “Click Chemistry for Future Gene Therapies to Benefit Citizens, Researchers and Industry” EU-Projekt OLIGOBINPRO “Non-canonical nucleoside incorporation into synthet-ic RNA oligonucleotides: investigations towards the discovery of RNA-binding” EU-Projekt PRENUCRNA “Prebiotic synthesis of Pyrimidine Nucleosides: new insights into RNA evolution”

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EU-Projekt EPiR “DNA as a training platform for photodynamic processes in soft materials” DFG Normalverfahren CA 275/8-5 “Synthese und Analyse modifizierter tRNA Ba-sen” DFG Normalverfahren CA 275/11-1 „Synthese von präbiotisch relevanten RNA-Nukleosiden und von Aminosäure-RNA-Konjugaten“ DFG SPP 1784 „Chemische Biologie natürlicher Nukleinsäuremodifikationen: Mengen und Funktionen nicht-kanonischer Nukleoside in messenger RNA“ Excellence Cluster EXC114 “Munich Center for Integrated Protein Science” Publications ˗ Scientific Papers Iwan I, Rahimoff R, Kirchner A, Spada F, Schröder AS, Kosmatchev O, Ferizaj S, Steinbacher J, Parsa E, Müller M, Carell T. 5-Formylcytosine to cytosine conver-sion by C-C bond cleavage in vivo. Nat. Chem. Biol. 2017, doi:10.1038/nchembio.2531. Michaelides IN, Tago N, Viverge B, Carell T. Synthesis of RNA Containing 5-Hydroxymethyl-, 5-Formyl-, and 5-Carboxycytidine. Chem. Eur. J. 2017, doi: 10.1002/chem.201704216. Carell T, Kurz MQ, Müller M, Rossa M, Spada F. Non-canonical bases in the ge-nome: The regulatory information layer in DNA. Angew. Chem. Int. Ed. 2017, doi: 10.1002/ange.201708228. Edupuganti RR, Geiger S, Lindeboom RGH, Shi H, Hsu PJ, Lu Z, Wang S-Y, Bal-tissen MPA, Jansen PWTC, Rossa M, Müller M, Stunnenberg HG, HE C*, Carell T*, Vermeulen M*. N6-methyladenosine (m6A) recruits and repels proteins to reg-ulate mRNA homeostasis. Nat. Struct. Mol. Biol. 2017, doi:10.1038/nsmb.3462. Kitsera N, Allgayer J, Parsa E, Geier N, Rossa M, Carell T, Khobta A. Functional impacts of 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxycytosine at a single hemi-modified CpG dinucleotide in a gene promoter. Nucleic Acids Res. 2017, doi: 10.1093/nar/gkx718. Rahimoff R, Kosmatchev O, Kirchner A, Pfaffeneder T, Spada F, Brantl V, Müller M, Carell T. 5-Formyl- and 5-carboxydeoxycytidines do not cause accumulation of harmful repair intermediates in stem cells. J. Am. Chem. Soc. 2017, doi: 10.1021/jacs.7b04131

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Raddaoui N, Stazzoni S, Möckl L, Viverge B, Geiger F, Engelke H, Bräuchle C, Carell T. Dendrimer-based signal amplification of click-labelled DNA in situ. ChemBioChem 2017, doi: 10.1002/cbic.201700209. Traube FR, Carell T. The chemistries and consequences of DNA and RNA methyl-ation and demethylation. RNA Biol. 2017, 25, 1-9 doi: 10.1080/15476286 Ebert C, Simon N, Schneider S, Carell T. Structural insights into the recognition of N2-aryl- and C8-aryl DNA lesions by the repair protein XPA/Rad14. ChemBio-Chem 2017, doi: 10.1002/cbic.201700169. Schiffers S, Ebert C, Rahimoff R, Kosmatchev O, Steinbacher J, Bohne A-V, Spa-da F, Michalakis S, Müller M, Carell T. Quantitative LC-MS Provides No Evidence for m6dA or m4dC in the Genome of Mouse Embryonic Stem Cells and Tissues. Angew. Chem. Int. Ed. 2017, doi: 10.1002/anie.201700424. Schröder AS, Parsa E, Iwan K, Traube FR, Wallner M, Serdjukow S, Carell T. 2´-(R)-Fluorinated mC, hmC, fC and caC triphosphates are substrates for DNA poly-merases and TET-enzymes. Chem. Commun. 2016, doi:10.1039/C6CC07517G. Heidinger L, Kneuttinger A, Kashiwazaki G, Weber S, Carell T, Schleicher E. Di-rect Observation of a Deoxyadenosyl Radical in an Active Enzyme Environment. FEBS Lett. 2016, doi:10.1002/1873-3468.12498. Dallmann A, Beribisky A, Gnerlich F, Rübbelke M, Schiesser S, Carell T, Sattler M. Site-Specific Isotope-Labeling of Inosine Phosphoramidites and NMR Analysis of an Inosine-Containing RNA Duplex. Chem. Eur. J. 2016, 22(43), 15350-15359 doi:10.1002/chem.201602784. Su M, Kirchner A, Stazzoni S, Müller M, Wagner M, Schröder AS, Carell T. 5-Formylcytosine could be a Semipermanent Base in Specific Genome Sites. Angew. Chem. Int. Ed. 2016, 55(39), 11797-11800 doi:10.1002/anie.201605994. Schröder AS, Kotljarova O, Parsa E, Iwan K, Raddaoui N, Carell T. Synthesis of (R)-Configured 2´-Fluorinated mC, hmC, fC, and caC Phosphoramidites and Oli-gonucleotides. Org. Lett. 2016, 18(17), 4368-4371 doi:10.1021/acs.orglett.6b02110. Thienpont B, Steinbacher J, Zhao H, D'Anna F, Kuchnio A, Ploumakis A, Ghesquière B, Van Dyck L, Boeckx B, Schoonjans L, Hermans E, Amant F, Kris-tensen VN, Koh KP, Mazzone M, Coleman M, Carell T, Carmeliet P, Lambrechts D. Tumour hypoxia causes DNA hypermethylation by reducing TET activity. Na-ture, 2016, 537, 63-68 doi:10.1038/nature19081.

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Greco CM, Kunderfranco P, Rubino M, Larcher V, Carullo P, Anselmo A, Kurz K, Carell T, Angius A, Latronico MVG, Papait R, Condorelli G. DNA hydroxymeth-ylation controls cardiomyocyte gene expression in development and hypertrophy. Nature Comm. 2016, 7, 12418 doi:10.1038/ncomms12418. Simon N, Ebert C, Schneider S. Structural Basis for Bulky-Adduct DNA-Lesion Recognition by the Nucleotide Excision Repair Protein Rad14. Chem. Eur. J. 2016, 22(31), 10782-10785 doi:10.1002/chem.201602438. Becker S, Thoma I, Deutsch A, Gehrke T, Mayer P, Zipse H, Carell T. A high-yielding, strictly regioselective prebiotic purine nucleoside formation pathway. Sci-ence, 2016, 352(6287), 833-836 doi:10.1126/science.aad2808. Koch SC, Simon N, Ebert C, Carell T. Molecular mechanisms of xeroderma pig-mentosum (XP) proteins. Quaterly Reviews of Biophysics, 2016, 49, e5 doi:10.1017/S0033583515000268. Bogdanovic O, Smits AH, de la Calle Mustienes E, Tena JJ, Ford E, Williams R, Senanayake U, Schultz MD, Hontelez S, van Kruijsbergen I, Rayon T, Gnerlich F, Carell T, Veenstra GJC, Manzanares M, Sauka-Spengler T, Ecker JR, Vermeulen M, Gómez-Skarmeta JL, Lister R. Active DNA demethylation at enhancers during the vertebrate phylotypic period. Nature Genetics, 2016, 48, 417-426 doi:10.1038/ng.3522. Klier L, Aranzamendi E, Ziegler D, Nickel J, Karaghiosoff K, Carell T, Knochel P. Lewis Acid Triggered Regioselective Magnesiation and Zincation of Uracils, Uri-dines, and Cytidines. Org. Lett. 2016, 18(5), 1068-1071 doi:10.1021/acs.orglett.6b00190. Datz S, Argyo C, Gattner MJ, Weiss V, Brunner K, Bretzler J, von Schirnding C, Torrano AA, Spada F, Varbel M, Engelke H, Bräuchle C, Carell T, Bein T. Genet-ically designed biomolecular capping system for mesoporous silica nanoparticles enables receptor-mediated cell uptake and controlled drug release. Nanoscale, 2016, 8, 8101-8110 doi:10.1039/C5NR08163G. Bucher DB, Kufner CL, Schulter AS, Carell T, Zinth W. UV-Induced Charge Transfer States in DNA Promote Sequence Selective Self-Repair. J. Am. Chem. Soc. 2016, 138(1), 186-190 doi:10.1021/jacs.5b09753.

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Organic Chemistry Dr. Dorian Didier Dorian was born in 1985 in Saint-Mandé (France) and studied chemistry at the University Paris 11 (Orsay, France). He carried out his master work at the same university in 2008, working with Dr. Collin and Dr. Bezzenine-Lafollée on samari-um(III)-catalysed asymmetric transformations. He received his PhD degree under the guidance of Dr. Schulz in 2011 (summa cum laude), having investigated charge-transfer-complexes for recycling of chiral catalysts. He then moved to the group of Prof. Marek at the Technion – Israel Institute of Technology (Haifa, Isra-el) for a first post-doctoral stay with a Schulich Fellowship to focus on the imple-mentation of organometallic strategies in one-pot organic transformations. In 2013, he obtained a Humboldt Fellowship to join the group of Prof. Knochel at the LMU (Munich, Germany) where he studied the behaviour of chiral organolithium spe-cies. Since march 2015, he has been leading his own research group at the LMU with a Liebig Fellowship. Research topics Our research activities are twofold. A first part of the projects is dedicated to de-veloping new tools for the construction and exploitation of unsaturated four-membered carbo- and heterocycles. To take on such challenge, we have assembled unique, selective and dependable sequences. Applications in the domain of drug discovery, asymmetric catalysis and chiral materials are currently under investiga-tions. A second part of the projects concerns the exploration of unprecedented or-ganometallic transformations such as catalyst-free boron-relayed cross-coupling reactions and novel organocerium species in stereoselective vinylations. Honors, Awards, Memberships JSP Fellowship – Bürgenstock Conference Thieme Chemistry Journal Award Liebig Fellowship Extramural Research Funding Funded by the Fonds der Chemischen Industrie

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Funded by the Deutsche Forschungsgemeinschaft Funded by the SonderForschungsBereich 749 Publications Methods for the Synthesis of Substituted Azetines A. N. Baumann, M. Eisold, A. Music, G. Haas, Y. M. Kiw, D. Didier* Org. Lett. 2017, 19, 5681–5684. Highlighted in OPR&D (November 2017) Stereoselective Access to Alkylidenecyclobutanes through γ-Selective Cross-Coupling Strategies, M. Eisold, D. Didier* Org. Lett. 2017, 19, 4046–4049. Highlighted in SynFacts: 2017, 13, 1041. Selected as “SynFacts of the month”. Stereoselective Sequence toward Biologically Active Fused Alkylidenecyclobu-tanes, A. N. Baumann, M. Eisold, D. Didier Org. Lett. 2017, 19, 2114–2117. Unsaturated Four-Membered Rings: Efficient Strategies for the Construction of Cyclobutenes and Alkylidenecyclobutanes M. Eisold, A. N. Baumann. G. M. Kiefl, S. T. Emmerling, D. Didier* Chem. Eur. J. 2017, 23, 1634-1644. Single-Pot Asymmetric Approach toward Enantioenriched Quaternary Stereocen-ter-Containing Alkylidenecyclobutanes M. Eisold, G. M. Kiefl, D. Didier*Org. Lett. 2016, 18, 3022-3025. Highly Diastereoselective Approach to Methylenecyclopropanes via Boron-Homologation / Allyl-Boration sequences A. Baumann, A. Music, K. Karaghiosoff, D. Didier* Chem. Commun. 2016, 52, 2529-2532.

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Organic Chemistry Dr. sc. ETH Zürich Henry Dube Born 1978 in Halle/Saale, 1998-2000 study of chemistry at Philipps-Universität Marburg, 2000-2004 study of chemistry at LMU München, 2008 PhD degree in the group of Prof. Dr. François Diederich, ETH Zürich, Switzerland (Synthetic Models for Heme Proteins), 2008-2011 Postdoc-Aufenthalt bei Prof. Dr. Julius Rebek, Jr., The Scripps Research Institute, La Jolla, USA, since 2011 Independent Group Leader at (Liebig Stipendiat des VCI, Emmy Noether-Stipendium der DFG) LMU München, Department of Chemistry Research Topics Functional supramolecular systems, molecular recognition, photoswitches, molecu-lar machines, organic synthesis, photochemistry, physical organic chemistry, pho-tophysics, biological chemistry Honors, Awards, Memberships Dr. Klaus Römer-Foundation Young Investigator Award Awarded "Best presentation of Early Career Researcher" at "Thinking the Unthink-able" GDCh Scientific Forum Chemistry 2017, Anniversary Congress GDCh - 150 years TCI Lecture Award at the 25. Nachwuchswissenschaftler-Symposium Bioorgan-ische Chemie 2016 Member of the Young Center (CASY) of the Center of Advanced Studies at the LMU Extramural Research Funding Emmy Noether-Fellowship of the German Research Foundation Collaborative Research Center, SFB 749 – Reactive Intermediates, German Re-search Foundation, VCI Fonds der Chemischen Industrie, Cluster of excellence CIPSM

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Publications – Scientific Papers Hemiindigo - Highly Bistable Photoswitching at the Biooptical Window, C. Peter-mayer, S. Thumser, F. Kink, P. Mayer, H. Dube, J. Am. Chem. Soc. 2017, 139, 15060-15067. Direct Observation of Hemithioindigo-Motor Unidirectionality, L. A. Huber, K. Hoffmann, S. Thumser, N. Böcher, P. Mayer, H. Dube, Angew. Chem. 2017, 129, 14728-14731; Angew. Chem. Int. Ed. 2017, 56, 14536-14539. Highlighted in Syn-facts 2018, 14, 0080 and Molekulare Motoren – Auf dem Weg zu smarten Nano-maschinen Laborpraxis 2017, 41, 34-35. Ingredients to TICT Formation in Donor Substituted Hemithioindigo, S. Wied-brauk, B. Maerz, E. Samoylova, P. Mayer, W. Zinth, H. Dube, J. Phys. Chem. Lett. 2017, 8, 1585-1592. Bistable Photoswitching of Hemithioindigo with Green and Red Light - Entry Point to Advanced Molecular Digital Information Processing, F. Kink, M. Polo Collado, S. Wiedbrauk, P. Mayer, H. Dube, Chem. Eur. J. 2017, 23, 6237-6243. (Frontispie-ce) Immer vorwärts, nie zurück, M. Schildhauer, H. Dube, Nachr. Chem. 2016, 64, 1049-1053. Photocontrol of Polar Aromatic Interactions by a bis-Hemithioindigo Based Helical Receptor, M. Guentner, E. Uhl, P. Mayer, H. Dube, Chem. Eur. J. 2016, 22, 16433-16436. Twisted Hemithioindigo Photoswitches: Solvent Polarity Determines the Type of Light-Induced Rotations. S. Wiedbrauk, B. Maerz, E. Samoylova, A. Reiner, F. Trommer, P. Mayer, W. Zinth, H. Dube, J. Am. Chem. Soc. 2016, 138, 12219-12227.

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Organic Chemistry Prof. Dr. rer. nat. Anja Hoffmann-Röder Born 1972 in Bonn, 1991-1994 laboratory assistant (vocational education, Degussa AG, Bonn) 1994-1999 study of chemistry at Univ. Bonn, 2003 PhD degree in the group of Prof. Dr. Norbert Krause, TU Dortmund, 2003-2005 Postdoctoral fellow in the group of Prof. Dr. François Diederich, ETH Zurich, Switzerland, 2005-2006 Liebig-Fellow (VCI) at Johannes-Gutenberg Univ. Mainz, 2006-2011 Emmy No-ether-Fellow (DFG) at Johannes-Gutenberg Univ. Mainz, 2009-2011 W1-professor Johannes-Gutenberg Univ. Mainz, since 2011 tenure track W2-professor LMU Munich. Research Topics Carbohydrate and glycopeptide chemistry: Synthesis of carbohydrate antigens and capsular polysaccharides; Use of fluorosugars and carbohydrate mimics for carbo-hydrate-based vaccines and biologically relevant glycoconjugates; Synthesis of peptide mimics for pharmaceutical applications; Fluorinations and fluoroorganic chemistry; Synthesis of photoswitchable peptidomimetics for structural biology and photopharmacology. Honors, Awards, Memberships Member of the German Chemical Society (GdCh) Member of the Alumni der Studienstiftung e.V. Extramural Research Funding DFG, Excellence Cluster Center for Integrated Protein Sciences Munich DFG, Collaborative Research Center 749 Dynamics and Intermediates of Molecu-lar Transformations DFG, Research Training Group GRK 2062 Molecular Principles of Synthetic Biol-ogy

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Publications – Scientific Papers Ralph Krafczyk, Jakub Macošek, Pravin Kumar Ankush Jagtap, Daniel Gast, Swetlana Wunder, Prithiba Mitra, Amit Kumar Jha, Jürgen Rohr, Anja Hoffmann-Röder, Kirsten Jung, Janosch Hennig, Jürgen Lassak, Structural Basis for EarP-Mediated Arginine Glycosylation of Translation Elongation Factor EF-P; mBio 2017, 8(5), e01412-17. doi: 10.1128/mBio.01412-17. Tom Podewin, Johannes Broichhagen, Christina Frost, Dieter Groneberg, Julia Ast, Helena Meyer-Berg, Nicholas H. F. Fine, Andreas Friebe, Martin Zacharias, David J. Hodson, Dirk Trauner, Anja Hoffmann-Röder, Optical control of a receptor-linked guanylyl cyclase using a photoswitchable peptidic hormone; Chem. Sci. 2017, 8, 4644-4653. doi: 10.1039/c6sc05044a. Amrei Deutsch, Christoph Jessen, Carl Deutsch, Konstantin Karaghiosoff, Anja Hoffmann-Röder, One-Pot Synthesis of Substituted Trifluoromethylated 2,3-Dihydro-1H-Imidazoles; Org. Lett. 2016, 18, 3474-3477. doi: 10.1021/acs.orglett.6b01672. Markus Daum, Frederik Broszeit, Anja Hoffmann-Röder, Synthesis of a Fluorinat-ed Sialophorin Hexasaccharide-Threonine Conjugate for Fmoc Solid-Phase Gly-copeptide Synthesis; Eur. J. Org. Chem. 2016, 3709-3720. doi: 10.1002/ejoc.201600523. Amrei Deutsch, Christian Wagner, Carl Deutsch, Anja Hoffmann-Röder, Convenient access to di- and trifluoroethylamines for lead structure re-search; Eur. J. Org. Chem. 2016, 930-945. doi: 10.1002/ejoc.201501576. Swetlana Wunder, Amrei Deutsch, Carl Deutsch, Anja Hoffmann-Röder, One-Pot Synthesis of Functionalized β-Fluoroalkylated Mannich-Type Products from N-Aryl N,O-Acetals. Synthesis 2016, 48, 1167-1176. doi: 10.1005/s-0035-1561324. Other Activities Faculty Mentor, LMUexcellent Mentoring Program. Grant reviewer for Deutsche Forschungsgemeinschaft, Alexander von Humboldt-Stiftung, Studienstiftung des Deutschen Volkes. Reviewer for Angewandte Chemie, Chemical Communications, European Journal of Organic Chemistry, Synthesis, Synlett, Chemistry – A Euro-pean Journal, Journal of Carbohydrate Chemistry, Journal of Fluorine Chemistry, Organic Letters, Chemical Science, ACS Central Science; Guest editor for Beilstein Journal of Organic Chemistry.

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Organic Chemistry Dr. rer. nat. Stefanie Kellner Born 1984 in Schorndorf/Baden-Württemberg, 2004-2008 study of pharmacy at Univ. Heidelberg, Approbation Apothekerin in 2009. In 2012 she obtained her doc-torate with Prof. M. Helm at the Johannes Gutenberg University of Mainz. After postdoctoral training with Prof. Peter C. Dedon at MIT (Cambridge, USA) in 2014-2016, she moved 2016 to the Department of Organic Chemistry here at the Ludwig-Maximilians-Universität (LMU) in Munich (Germany). Research Topics Analytical chemistry of ribonucleic acids (RNA) with the focus on natural RNA modifications. With mass spectrometric tools and metabolic labeling, questions to-wards the diversity, function and influence of RNA modifications on stress survival are answered. Extramural Research Funding Emmy-Noether-Fellowship of the German Research Foundation (DFG) Excellence Cluster EXC114 “Munich Center for Integrated Protein Science” CIPSM Associated with the Priority Program SPP 1784 of the German Research Founda-tion (DFG) Publications – Scientific Papers Heiss, M., Reichle, V.F. & Kellner, S. Observing the fate of tRNA and its modifi-cations by nucleic acid isotope labeling mass spectrometry: NAIL-MS. RNA Biol, 1-9 (2017). Kellner, S. et al. Oxidation of phosphorothioate DNA modifications leads to lethal genomic instability. Nat Chem Biol (2017). Dewe, J.M., Fuller, B.L., Lentini, J.M., Kellner, S.M. & Fu, D. TRMT1-catalyzed tRNA modifications are required for redox homeostasis to ensure proper cellular proliferation and oxidative stress survival. Mol Cell Biol (2017).

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Heiss, M. & Kellner, S. Detection of nucleic acid modifications by chemical rea-gents. RNA Biol, 0 (2016). Thiaville, J.J. et al. Novel genomic island modifies DNA with 7-deazaguanine derivatives. Proc Natl Acad Sci U S A (2016). Kaiser, S. et al. The RNA methyltransferase Dnmt2 methylates DNA in the struc-tural context of a tRNA. RNA Biol, 1-11 (2016).

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Organic Chemistry Univ.-Prof. Dr. Paul Knochel Born 1955, Strasbourg (France), studied chemistry at the Ecole Nationale Supéri-eure de Chimie (Strasbourg, France), 1982 PhD with Prof. Seebach (ETH Zurich, Switzerland), 1983 Habilitation with Prof. Normant at the Université Pierre et Ma-rie Curie (Paris, France), 1986-1987 postdoctoral fellow at Princeton University (New jersey, USA), 1987-1991 Assistant Professor at the University of Michigan (Ann Arbor, USA), 1991 Full Professor at the University of Michigan (Ann Arbor, USA), 1992-1999 C4-Professor for Organic Chemistry at the Philipps-University Marburg, since 1999 C4-Professor at the Department of Chemistry, LMU Universi-ty of Munich, 2005-2007 Dean of the Faculty of Chemistry and Pharmacy. Research topics Preparation of novel functionalized zinc, magnesium, aluminum, zirconium, lan-thanum, iron, manganese, copper and indium organometallic reagents. New nickel, palladium, iron, chromium and cobalt-catalyzed cross-coupling reactions. New fluorination of aromatics and heterocycles. Preparation of new ligands for asym-metric catalysis. Development of new sterically hindered TMP bases. New metal activation methods, Lewis acid-controlled reactivity of organometallic compounds. Honors, Awards, Memberships Member of „Gesellschaft Deutscher Chemiker e.V.“ Member of „American Chemical Society“ Member of „Académie des Sciences“, Paris, Frankreich Member of „Bayerische Akademie der Wissenschaften“ Member of „Deutsche Akademie der Naturforscher Leopoldina“ Extramural Research Funding Funded by Alexander von Humboldt-Stiftung Funded by Albemarle Germany GmbH Funded by Novartis Pharma AG: Synthesis and functionalization of 6- and 7-azaindoles

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Funded by Novartis Pharma AG: New Fe-catalyzed cross-couplings with heterocy-clic halides Funded by DFG: SFB749-Dynamics and Intermediates of Molecular Transfor-mations Publications Castello-Mico, Alicia; Herbert, Simon A.; Leon, Thierry; Bein, Thomas; Knochel, P.* “Functionalizations of Mixtures of Regioisomeric Aryllithium Compounds by Selective Trapping with Dichlorozirconocene” Angew. Chem. Int. Ed. 2016, 55, 401. Greiner, R.; Blanc, R.; Petermayer, C.; Karaghiosoff, K.; Knochel, P.* “Preparation of Functionalized 2,7-Naphthyridines by Directed Lithiation with (2,2,6,6-Tetramethylpiperidyl)lithium and Their Regioselective Iron-Catalyzed Cross Cou-plings” Synlett 2016, 27, 231-236. Nafe, J.; Knochel, P.* “Selective Metalation of 1,3-Dithiole-2-thiones: An Effec-tive Preparation of New Symmetrically and Nonsymmetrically Tetraarylated Tetrathiafulvalenes” Synthesis 2016, 48, 103-114. Benischke, A. D.; Ellwart, M.; Becker, M. R.; Knochel, P.* „Polyfunctional Zinc and Magnesium Organometallics for Organic Synthesis: Some Perspectives” Syn-thesis 2016, 48, 1101-1107. Benischke, A. D.; Knoll, I.; Rerat, A.; Gosmini, C.; Knochel, P.* „A practical co-balt-catalyzed cross-coupling of benzylic zinc reagents with aryl and heteroaryl bromides or chlorides” Chem. Comm. 2016, 52, 3171-3174.

Haas, D.; Hammann, J. M.; Greiner, R.; Knochel, P.* “Recent Developments in Negishi Cross-Coupling Reactions” ACS Catal. 2016, 6, 1540-1552.

Ganiek, M. A.; Becker, M. R.; Ketels, M.; Knochel, P.* “Continuous Flow Magne-siation or Zincation of Acrylonitriles, Acrylates, and Nitroolefins. Application to the Synthesis of Butenolides” Org. Lett. 2016, 18, 828-831. Benischke, A. D.; Breuillac, A. J. A.; Moyeux, A.; Cahiez, G.; Knochel, P.* “Iron-Catalyzed Cross-Coupling of Benzylic Manganese Chlorides with Aryl and Het-eroaryl Halides” Synlett 2016, 27, 471-476.

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Haas, D.; Hammann, J. M.; Lutter, F. H.; Knochel, P.* “Mild Cobalt-Catalyzed Negishi Cross-Couplings of (Hetero)arylzinc Reagents with (Hetero)aryl Halides” Angew. Chem., Int. Ed. 2016, 55, 3809-3812. Klier, L.; Aranzamendi, E.; Ziegler, D.; Nickel, J.; Karaghiosoff, K.; Carell, T.; Knochel, P.* „Lewis Acid Triggered Regioselective Magnesiation and Zincation of Uracils, Uridines, and Cytidines” Org. Lett. 2016, 18, 1068-1071. Barroso, S.; Lemaire, S.; Farina, V.; Steib, A. K.; Blanc, R.; Knochel, P.* “Cine Substitution with Arylzinc Reagents: Scope and Mechanistic Studies” J. Org. Chem. 2016, 81, 2804-2816. Becker, M. R.; Knochel, P.* „High-Temperature Continuous-Flow Zincations of Functionalized Arenes and Heteroarenes Using (Cy2N)2Zn·2LiCl” Org. Lett. 2016, 18, 1462-1465. Lohse, M. S.; Rotter, J. M.; Margraf, J. T.; Werner, V.; Becker, M.; Herbert, S.; Knochel, P.*; Clark, T.; Bein, T.; Medina, D. D. „From benzodithiophene to dieth-oxy-benzodithiophene covalent organic frameworks - structural investigations” CrystEngComm 2016, 18, 4295-4302. Shen, Z.-L.; Dhayalan, V.; Benischke, A. D.; Greiner, R.; Karaghiosoff, K.; Mayer, P.; Knochel, P.* „Polyfunctional Lithium, Magnesium, and Zinc Alkenyl Reagents as Building Blocks for the Synthesis of Complex Heterocycles” Angew. Chem., Int. Ed. 2016, 55, 5332-5336. Quinio, P.; Kohout, L.; Roman, D. S.; Gaar, J.; Karaghiosoff, K.; Knochel, P.* „Sc(OTf)3-Catalyzed Addition of Bromomagnesium 2-Vinyloxy Ethoxide to Vari-ous Aldehydes Leading to Protected Aldol Products” Synlett 2016, 27, 1715-1719. Moriya, K.; Schwaerzer, K.; Karaghiosoff, K.; Knochel, P.* „Stereoselective Syn-thesis of Secondary Alkyllithiums and Their Application to Stereoselective Cupra-tions or Intramolecular Carbolithiations for the Stereoselective Synthesis of Alkyli-denecyclobutanes” Synthesis 2016, 48, 3141-3154. Morozova, V.; Moriya, K.; Mayer, P.; Knochel, P.* “Stereoselective Synthesis and Retentive Trapping of α-Chiral Secondary Alkyllithiums Leading to Stereodefined α,β-Dimethyl Carboxylic Esters” Chem. Eur. J. 2016, 22, 9962-9965. Fernandez, S.; Ganiek, M. A.; Karpacheva, M.; Hanusch, F. C.; Reuter, S.; Bein, T.; Auras, F.; Knochel, P.* „Synthesis and Reactivity of Triazaphenanthrenes” Org. Lett. 2016, 18, 3158-3161.

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Ellwart, M.; Makarov, I. S.; Achrainer, F.; Zipse, H.; Knochel, P.* „Regioselective Transition-Metal-Free Allyl-Allyl Cross-Couplings” Angew. Chem. Int. Ed. 2016, 55, 10502-10506. Benischke, A. D.; Leroux, M.; Knoll, I.; Knochel, P.* „Iron-Catalyzed Acylation of Polyfunctionalized Aryl- and Benzylzinc Halides with Acid Chlorides” Org. Lett. 2016, 18, 3626-3629. Nickel, J.; Fernandez, M.; Klier, L.; Knochel, P.* „Synthesis of Pyrrolo[2,3-d]pyrimidines by Copper-Mediated Carbomagnesiations of N-Sulfonyl Ynamides and Application to the Preparation of Rigidin A and a 7-Azaserotonin Derivative” Chem. Eur. J. 2016, 22, 14397-14400. Hammann, J. M.; Haas, D.; Tuellmann, C.-P.; Karaghiosoff, K.; Knochel, P.* „Di-astereoselective Cobalt-Mediated Cross-Couplings of Cycloalkyl Iodides with Al-kynyl or (Hetero)Aryl Grignard Reagents” Org. Lett. 2016, 18, 4778−4781. Greshock, T. J.;* Moore, K. P.; McClain, R. T.; Bellomo, A.; Chung, C. K.; Dreher, S. D.; Kutchukian, P. S.; Peng, Z.; Davies, I. W.; Vachal, P.; Ellwart, M.; Manolikakes, S M.; Knochel, P.* and Nantermet, P. G. “Synthesis of Complex Druglike Molecules by the Use of Highly Functionalized Bench-Stable Organozinc Reagents” Angew. Chem. Int. Ed. 2016, 55, 13714-13718. Knochel, P. “Jean F. Normant (1936-2016)“ Angew. Chem. Int. Ed. 2016, 55, 13376. Haas, D.; Sustac-Roman, D.; Schwarz, S.; Knochel, P.* „Directed Zincation with TMPZnCl·LiCl and Further Functionalization of the Tropolone Scaffold” Org. Lett. 2016, 18, 6380-6383. Hofmayer, M. S.; Hammann, J. M.; Haas, D.; Knochel, P.* „Cobalt-Catalyzed C(sp2)-C(sp3) Cross-Coupling Reactions of Diarylmanganese Reagents with Sec-ondary Alkyl Iodides” Org. Lett. 2016, 18, 6456-6459. Bellan, A. B.; Kuzmina, O. M.; Vetsova, V. A.; Knochel, P.* „Chromium-Catalyzed Cross-Coupling Reactions of Alkylmagnesium Reagents with Halo-Quinolines and Activated Aryl Chlorides” Synthesis 2017, 49, 188-194. Cai, Y.; Benischke, A. D.; Knochel, P.*; Gosmini, C. „Cobalt-Catalyzed Reductive Cross-Coupling Between Styryl and Benzyl Halides” Chem. Eur. J. 2017, 23, 250-253.

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Benischke, A. D.; Le Corre, G.; Knochel, P.* „Preparation of Polyfunctional Or-ganozinc Halides by an InX3- and LiCl-Catalyzed Zinc Insertion to Aryl and Het-eroaryl Iodides and Bromides” Chem. Eur. J. 2017, 23, 778-782. Hammann, Jeffrey M.; Lutter, Ferdinand H.; Haas, Diana; Knochel, P.* “A Robust and Broadly Applicable Cobalt-Catalyzed Cross-Coupling of Functionalized Bench-Stable Organozinc Pivalates with Unsaturated Halides” Angew. Chem. Int. Ed. 2017, 56, 1082-1086. Castello-Mico, A.; Nafe, J.; Higashida, K.; Karaghiosoff, K.; Gingras, M.; Knochel, P.* „Selective Metalations of 1,4-Dithiins and Condensed Analogues Us-ing TMP-Magnesium and -Zinc Bases” Org. Lett. 2017, 19, 360-363. Balkenhohl, M.; Francois, C.; Sustac-Roman, D.; Quinio, P.; Knochel, P.* “Transi-tion-Metal-Free Amination of Pyridine-2-sulfonyl Chloride and Related N-Heterocycles Using Magnesium Amides” Org. Lett. 2017, 19, 536-539. Knochel, P. „Preface - Burgenstock Junior Contributions” Synthesis 2017, 49, 775. Ketels, M.; Konrad, D. B.; Karaghiosoff, K.; Trauner, D.; Knochel, P.* „Selective Lithiation, Magnesiation, and Zincation of Unsymmetrical Azobenzenes Using Continuous Flow” Org. Lett. 2017, 19, 1666-1669. Klier, L.; Ziegler, D. S.; Rahimoff, R.; Mosrin, M.; Knochel, P.* „Practical Large-Scale Regioselective Zincation of Chromone Using TMPZnCl·LiCl Triggered by the Presence or Absence of MgCl2” Org. Process Res. Dev. 2017, 21, 660-663. Chen, Y.-H.; Ellwart, M.; Toupalas, G.; Ebe, Y.; Knochel, P.* „Preparation and Application of Solid, Salt-Stabilized Zinc Amide Enolates with Enhanced Air and Moisture Stability” Angew. Chem. Int. Ed. 2017, 56, 4612-4616. Hofmayer, M. S.; Hammann, J. M.; Lutter, F. H.; Knochel, P.* „Large-Scale Co-balt-Catalyzed Cross-Couplings of Functionalized Bench-Stable Arylzinc Pivalates with (Hetero)Aryl and Alkenyl Halides” Synthesis 2017, 49, 3925-3930. Rager, S.; Dogru, M.; Werner, V.; Gavryushin, A.; Goetz, M.; Engelke, H.; Medi-na, D. D.; Knochel, P.*; Bein, T. „Pore wall fluorescence labeling of covalent or-ganic frameworks” CrystEngComm 2017, 19, 4886-4891. Hammann, J. M.; Hofmayer, M. S.; Lutter, F. H.; Thomas, L.; Knochel, P.* “Re-cent Advances in Cobalt-Catalyzed Csp2 and Csp3 Cross-Couplings” Synthe-sis 2017, 49, 3887-3894.

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Chen, Y.-H.; Ellwart, M.; Malakhov, V.; Knochel, P.* „Solid organozinc pivalates: a new class of zinc organometallics with greatly enhanced air- and moisture-stability” Synthesis 2017, 49, 3215-3223. Ketels, M.; Ziegler, D. S.; Knochel, P.* „Selective Zincation of 1,2-Dicyanobenzene and Related Benzonitriles in Continuous Flow Using In Situ Trapping Metalations” Synlett 2017, in print. Chen, Y.-H.; Tuellmann, C. P.; Ellwart, M.; Knochel, P.* „Preparation of Solid Polyfunctional Alkynylzinc Pivalates with Enhanced Air and Moisture Stability for Organic Synthesis” Angew. Chem. Int. Ed. 2017, 56, 9236-9239. Hammann, J. M.; Thomas, L.; Chen, Y.-H.; Haas, D.; Knochel, P.* „Cobalt-Catalyzed Cross-Couplings of Bench-Stable Alkynylzinc Pivalates with (Hetero)Aryl and Alkenyl Halides” Org. Lett. 2017, 19, 3847-3850. Nishii, Y.; Hirai, T.; Fernandez, S.; Knochel, P.*; Mashima, K. „Zinc-Catalyzed Esterification of N-β-Hydroxyethylamides: Removal of Directing Groups under Mild Conditions” Eur. J. Org. Chem. 2017, 5010-5014. Ganiek, M. A.; Becker, M. R.; Berionni, G.; Zipse, H.; Knochel, P.* „Barbier Con-tinuous Flow Preparation and Reactions of Carbamoyllithiums for Nucleophilic Amidation” Chem. Eur. J. 2017, 23, 10280-10284. Knochel, P.* “Preface - Special Issue Dedicated to Professor Herbert Mayr” Syn-thesis 2017, 49, I. Balkenhohl, Moritz; Greiner, Robert; Makarov, Ilya S.; Heinz, Benjamin; Karaghi-osoff, Konstantin; Zipse, Hendrik; Knochel, P.* „Zn-, Mg-, and Li-TMP Bases for the Successive Regioselective Metalations of the 1,5-Naphthyridine Scaffold (TMP=2,2,6,6-Tetramethylpiperidyl)” Chem. Eur. J. 2017, 23, 13046-13050. Nishii, Y.; Hirai, T.; Fernandez, S.; Knochel, P.*; Mashima, K. „Cover Feature: Zinc-Catalyzed Esterification of N-β-Hydroxyethylamides: Removal of Directing Groups under Mild Conditions (Eur. J. Org. Chem. /2017)“ Eur. J. Org. Chem. 2017, 4995. Ellwart, M.; Hoefner, G.; Gerwien, A.; Wanner, K. T.; Knochel, P.* „Synthesis and Bioactivity of Novel N-Benzylic and N-Phenethylic Ephedrine Derivatives” Syn-thesis 2017, in print.

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Castello-Mico, A.; Knochel, P.* “Zincation and Magnesiation of Functionalized Silylated Cyanohydrins Using TMP-Bases” Synthesis 2017, in print. Makarov, I. S.; Brocklehurst, C. E.; Karaghiosoff, K.; Koch, G.; Knochel, P.* „Synthesis of Bicyclo[1.1.1]pentane Bioisosteres of Internal Alkynes and para-Disubstituted Benzenes from [1.1.1]Propellane” Angew. Chem. Int. Ed. 2017, 56, 12774-12777. Hofmayer, M. S.; Hammann, J. M.; Cahiez, G.; Knochel, P.* „Iron-Catalyzed C(sp2)-C(sp3) Cross-Coupling Reactions of Di(hetero)arylmanganese Reagents and Primary and Secondary Alkyl Halides” Synlett 2017, in print. Ketels, M.; Ganiek, M. A.; Weidmann, N.; Knochel, P.* „Synthesis of Polyfunc-tional Diorganomagnesium and Diorganozinc Reagents through In Situ Trapping Halogen-Lithium Exchange of Highly Functionalized (Hetero)aryl Halides in Con-tinuous Flow” Angew. Chem. Int. Ed. 2017, 56, 12770-12773. Greiner, R.; Ziegler, D. S.; Cibu, D.; Jakowetz, A. C.; Auras, F.; Bein, T.; Knochel, P.* „Preparation of Polyfunctional Naphthyridines by Cobalt-Catalyzed Cross-Couplings of Halogenated Naphthyridines with Magnesium and Zinc Organometal-lics” Org. Lett. 2017, 19, 6384-6387. Ziegler, D. S.; Greiner, R.; Lumpe, H.; Kqiku, L.; Karaghiosoff, K.; Knochel, P.* „Directed Zincation or Magnesiation of the 2-Pyridone and 2,7-Naphthyridone Scaffold Using TMP Bases” Org. Lett. 2017, 19, 5760-5763. Benischke, A. D.; Anthore-Dalion, L.; Berionni, G.; Knochel, P.* „Preparation of Functionalized Diaryl- and Diheteroaryllanthanum Reagents by Fast Halogen-Lanthanum Exchange” Angew. Chem. Int. Ed. 2017, 56, 16390-16394. Other Activities Synthesis Editor Synfacts Editor Editor „Comprehensive Organic Synthesis II“, Elsevier

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Organic chemistry Prof. Dr. rer. nat. Heinz Langhals Born 1948 in Altena/Westf, 1967-1971 study of chemistry at the University of Münster/Westf., diploma (master) 1972 in Münster, 1974 PhD degree at the Uni-versity of Freiburg i.Br. (group of Prof. C. Rüchardt), 1975 postdoctoral fellow at Ecole Normale Supérieure in Paris (group of Prof. Marc Julia, organic chemistry), 1976 postdoctoral fellow (Liebig scholarship) at the University Zürich (group of Prof. Hanns Fischer, physical chemistry), Habilitation 1981 at the University of Freiburg i.Br., 13.12.1983 Werner von Siemens medal for young scientists, since 1984 C3-professor LMU Munich, September 2002, June 2004 and September 2007 research at the Bingmayong Museum in Lintong/China, July 2007 guest professor at the ENS de Cachan/Paris (France), March 2010 guest at the University of War-saw (Poland), July 2013 guest professor at the University of Linz (JKU, LIOS, Austria), 31.3.2014 termination of obligations at LMU because of pension age, since 1.4.2014 Teaching and Research Fellow at JKU, 1.11.2014-31.3.2015 Johann Gottfried Herder scholarship (DAAD) for senior scientists at JKU, 9.4.2015 award for industrial innovation in energy and environment: "INDUSTRIEPREIS 2015 Energie & Umwelt", 1.11.2015-31.3.2016 Johann Gottfried Herder scholarship (DAAD) for senior scientists at JKU, 28.11.2017 Nominated for the award in the efficiency of resources "Deutscher Rohstoff-effizienz-Preis 2017", since April 2014 Free R&D and teaching at the Universities LMU and JKU. Research Topics Organic chemistry; dye chemistry: preparation and investigation of highly stable fluorescent dyes, molecular electronics, organic solar systems, nanotechnology; reaction mechanisms: rearrangements; solvent effects: polar properties of solvent mixtures; analytics: water determination, fluorescent marker, fluorescent immuno-assays; polymer chemistry: polymeric natural products, recycling of polymers, con-servation of archaeological objects d'art. Honors, Awards, Memberships Nominated for the award in the efficiency of resources: Deutscher Rohstoff-effizienz-Preis 2017. 2016 and 2017: Guest professor and Teaching and Research Fellow at the Johan-nes-Kepler-University in Linz (JKU), Austria (LIOS).

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Memberships: Gesellschaft Deutscher Chemiker, Liebig-Vereinigung für Organi-sche Chemie, American Chemical Society (ACS), Deutscher Hochschulverband. Extramural Research Funding BMBF, PG, Bayerische Forschungsstiftung, Scutum Capital. Publications – Scientific Papers H. Langhals, 'Nanomicelles. Tiny but full of possibilities for chemistry', GIT La-bor-Fachzeitschr. 2016, 60(1), 30-32; Chem. Abstr. 2016, AN1472897. H. Langhals, 'Effizientes Sortieren von Kunststoffen', analytica pro. Das offizielle Messe-Magazin 2016, 58-59. H. Langhals, 'Nano-Micelles. Tiny, however, with big potential for chemistry', G.I.T. Laboratory Journal EUROPE 2016, 2016/7-8, 24-25. H. Langhals, 'Solvent skin - external and internal surfaces of liquids', Nachr. Chem. Tech. Lab. 2016, 64, 1065-1070; ; Chem. Abstr. 2016, AN1849867. R. Greiner, T. Schlücker, D. Zgela, H. Langhals, 'Fluorescent aryl naphthalene di-carboximides with large Stokes' shifts and strong solvatochromism controlled by dynamics and molecular geometry', J. Mater. Chem. C 2016, 4, 11244-11252; DOI: 10.1039/C6TC04453K. H. Langhals, 'Ein einfacher Demonstrationsversuch: Micellen als chemische Nano-Laboratorien', Chemie in unserer Zeit 2017, 51, 156-160; DOI: 10.1002/ciuz.201600738. H. Langhals, 'Heterocyclic structures applied as efficient molecular probes for the investigation of chemically important interactions in the liquid phase', Chem. Het-erocycl. Compd. 2017, 53, 2-10; DOI: 10.1007/s10593-017-2014-z. H. Langhals, M. Eberspächer, P. Mayer, 'Uncatalysed C-H amination of aromatics under unusually mild conditions, with negative enthalpies of activation', Asian J. Org. Chem. 2017, 6, 1080-1085 http://onlinelibrary.wiley.com/doi/10.1002/ajoc.201700106/pdf.

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H. Langhals, 'A concept for molecular addressing by means of far-reaching elec-tromagnetic interactions in the visible', J. Electr. & Electron. Systems 2017, 6, 215; http://dx.doi.org/10.4172/2332-0796.1000215. H. Langhals, 'Interaction of components in molecular optoelectronics for the next generation of IT devices', Scientific Review 2017, 3, 17-28; http://arpgweb.com/?ic=journal&journal=10&info=archive&month=03-2017&issue=3&volume=3. H. Langhals, T. Schlücker, H. Ernst, 'Novel spectrophotometric protocol for the long-term characterization of the hue of artwork', Analytical Lett. 2017, 50, 2270-2278; http://dx.doi.org/10.1080/00032719.2017.1281936. C. U. Missling, K. Sünkel, H. Langhals, W. Beck, 'Organometallic Lewis acids, part CXII. Chiral carbonyl-cyclopentadienyl-triphenylphosphine-iron and -ruthenium complexes with novel tertiary nitriles. [CpM(CO)(PPh3)(N≡C-CR1R2R3)]+ BF4

- (M = Fe, Ru)', ZAAC 2017, 643, 1262–1268; DOI: 10.1002/zaac.201700235. Patent applications H. Langhals, T. Schlücker, D. Zgela, 'Die Fluoreszenz, insbesondere die Fluores-zenzabklingzeit von pyrogenem Siliciumdioxid als Sonde für die Untersuchung von Medien, insbesondere von Polymermaterialien', Ger. Offen. DE 102016001546.2 (February 10, 2016). H. Langhals, T. Schlücker, R. Greiner, D. Zgela, 'Stark fluoreszierende und solva-tochrome Naphthalincarboximide mit Phenyl- und Naphthyl-Substituenten', Ger. Offen. DE 102016004396.2 (April 7, 2016). H. Langhals, M. Eberspächer, 'Eine effiziente Synthese für Benzoperylen-Derivate. Verbesserung der Diels-Alder-Clar-Reaktion', Ger. Offen. DE 102016010081.8 (August 12, 2016). H. Langhals, M. Eberspächer, 'Aminierung von Aromaten unter ungewöhnlich mil-den Bedingungen mit negativer Aktivierungsenergie und ohne Zusatz weiterer Re-agenzien', Ger. Offen. DE 102016014502.1 (December 1, 2016). H. Langhals, 'Neue Möglichkeiten zur molekularen Adressierung', Ger. Offen. DE 102017000953.8 (February 1, 2017). H. Langhals, R. Greiner, T. Schlücker, 'Perylen-Fluoreszenzfarbstoffe mit erhöhtem mediengesteuertem Stokes-Shift', Ger. Offen. DE 102017005186.0 (May 31, 2017).

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Organic Chemistry Prof. Dr. rer. nat. Rasmus Linser Born in 1980 in Walsrode, Germany, he studied chemistry at the University Göttin-gen, Germany, and Universidad Autónoma de Madrid, Spain, and did his PhD with Bernd Reif at the FMP in Berlin. After postdoctoral work at the Analytical Centre of the University of New South Wales (UNSW), Sydney, Australia, he held a Dis-covery Early Career Research Award-financed dual appointment at UNSW and Harvard Medical School, Boston, MA, USA, in the lab of Gerhard Wagner. After two years as a Liebig- (VCI) and Emmy Noether (DFG)-funded junior group leader at the Max Planck Institute for biophysical chemistry in Göttingen, he was appoint-ed Associate Professor at the Ludwig-Maximilians-University in Munich. Research Topics Methods development in Nuclear Magnetic Resonance spectroscopy and their ap-plication for the characterization of protein properties with atomic resolution. New approaches for resonance assignment, structure calculation, assessment of protein dynamics, protein:small molecule interactions, protein:water interactions. Micro-second-timescale motion. Functionality of membrane proteins. Stable-isotope label-ing. Characterization of inorganic compounds and materials. Honors, Awards, Memberships “Felix Bloch Lecture”: Award of the Gesellschaft Deutscher Chemiker (GDCh) for excellent achievements in magnetic resonance spectroscopy. Member Excellence Cluster CIPSM. Member Center for NanoScience (CeNS), Munich. Member LMU Center for Advanced Studies, Munich. Member SFB 749 Extramural Research Funding Collaborative Research Center 749 (German Research Council) “Dynamics and Intermediates of Molecular Transformations” Emmy Noether project 270263529 (German Research Council) “Entwicklung und Anwendung von protonendetektierter Festkörper-NMR-Spektroskopie zur Aufklä-

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rung von Membranproteinfunktionalität” Excellence Cluster EXC114 “Munich Center for Integrated Protein Science” Publications – Scientific Papers J. Cramer, J. Schiebel, T. Wulsdorf, K. Grohe, E. E. Najbauer, F. R. Ehrmann, N. Radeva, N. Zitzer, U. Linne, R. Linser, A. Heine, G. Klebe, “A False-Positive Screening Hit in Fragment-Based Lead Discovery: Watch out for the Red Herring”, Angew. Chem., Int. Ed., 56 (7), 1908–1913 (2017), J. Cramer, J. Schiebel, T. Wulsdorf, K. Grohe, E. E. Najbauer, F. R. Ehrmann, N. Radeva, N. Zitzer, U. Linne, R. Linser, A. Heine, G. Klebe, “Falsch-positiver Tref-fer im Fragment-basierten Wirkstoffdesign: Lass Dich nicht auf die falsche Fährte locken!”, Angew. Chem., 129 (7), 1934–1940 (2017). S. Xiang, N. Kulminskaya, B. Habenstein, J. Biernat, K. Tepper, M. Paulat, C. Griesinger, S. Becker, A. Lange, E. Mandelkow, R. Linser, “A two-component ad-hesive: Tau fibrils arise from a combination of a well-defined motif and conforma-tionally flexible interactions”, J. Am. Chem. Soc., 139, 2639−2646 (2017). G. Jaipuria, A. Leonov, K. Giller, S. K. Vasa, L. Jaremko, M. Jaremko, R. Linser, S. Becker, M. Zweckstetter, “Cholesterol-mediated allosteric regulation of the mi-tochondrial translocator protein structure”, Nature Comm., 8, 14893, (2017). K. Grohe, K. Tekwani Movellan, S. K. Vasa, K. Giller, S. Becker, R. Linser, “Non-equilibrium hydrogen exchange for determination of H-bond strength and water accessibility in solid proteins”, J. Biomol. NMR, 68 (1), 7-17 (2017). D. F. Gauto, A. Hessel, P. Rovó, V. Kurauskas, R. Linser, P. Schanda, “Protein conformational dynamics studied by 15N and 1H R1ρ relaxation dispersion: Applica-tion to wild-type and G53A ubiquitin crystals”, Solid State Nucl. Mag., 87, 86-95 (2017). P. Rovó, R. Linser, “Microsecond timescale proton rotating-frame relaxation under magic angle spinning”, J. Phys Chem. 121 (25), 6117–6130 (2017). D. Fischer, A. von Mankowski, A. Ranft, S. K. Vasa, R. Linser, J. Mannhart, B. V. Lotsch, “ZIF-8 films prepared by femtosecond pulsed-laser-deposition”, Chem. Mater. 29 (12), 5148–5155 (2017).

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R. Linser, “Solid-state NMR spectroscopic trends for supramolecular assemblies and protein aggregates”, invited “Trends” article in Solid state Nucl. Magn. Res. 87:45-53 (2017). P. Rovó, R. Linser, “Microsecond timescale solid-state backbone dynamics: a hy-brid NMR approach”, just accepted, ChemPhysChem, DOI: 10.1002/cphc.201701238 (2017). R. Linser, “Protons as sensitive reporters for molecular details.”, in the research report of the Max Planck Society (2016), DOI: 10.17617/1.J. N. Kulminskaya, S. K. Vasa, K. Giller, S. Becker, A. Kwan, M. Sunde, R. Linser, “Access to side-chain carbon information in deuterated solids under ultra-fast MAS through non-rotor-synchronized mixing”, Chem. Commun., 52 (2), 268-271 (2016). Back cover feature: Chem. Commun., 52(2), 419 (2016). S. K. Vasa, P. Rovó, K. Giller, S. Becker, R. Linser, “Access to Aliphatic Protons as Reporters in Non-Deuterated Proteins by Second-Order Transfer”, PhysChem-ChemPhys, 18, 8359 – 8363 (2016). Back cover: PhysChemChemPhys 18, 8754 (2016). J. I. Schweizer, M. G. Scheibel, M. Diefenbach, F. Neumeyer, C. Würtele, N. Kul-minskaya, R. Linser, N. Auner, S. Schneider, M. C. Holthausen, “A Disilene Base Adduct with a Dative Si–Si Single Bond”, Angew. Chem., Int. Ed., 55 (5), 1782-1786 (2016). S. Xiang, J. Biernat, E. Mandelkow, S. Becker, R. Linser, “Backbone assignment for minimal protein amounts of low structural homogeneity in the absence of deu-teration”, Chem. Commun., 52, 4002-4005 (2016). Cover: Chem. Commun., 52, 3979-3979 (2016) I. Gonzalo-Juan, D. U. Tulyaganov, C. Balan, R. Linser, J. M. F. Ferreira, R. Riedel, E. Ionescu, “Tailoring the viscoelastic properties of injectable biocompo-sites: A spectroscopic assessment of the interactions between organic carriers and bioactive glass particles”, Mater. Design, 97, 45-50 (2016). R. Linser, “Michael L. Johns, Einar O. Fridjonsson, Sarah Vogt, and Agnes Haber (Eds.): Mobile NMR and MRI. Developments and applications.”, Anal. Bioanal. Chem. 408 (15), 3929-3931 (2016).

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Organic Chemistry Univ.-Prof. Dr. rer. nat. Thomas Magauer Born in 1983. Chemistry studies at the University of Vienna (2002–2009). Postdoc-toral studies at Harvard University (2010–2012). Start of independent research at LMU Munich in 2012. Since 2017, ERC Starting Grant and Full Professor of Syn-thesis and Synthetic Methods at the University of Innsbruck. Research Topics Synthetic Methodology Natural Products Heterocyclic Chemistry Total Synthesis High Pressure Chemistry Honors and Awards 2017 DECHEMA Early-Career Researcher Prize for Natural Product Research 2017 Goering Visiting Professor in Organic Chemistry 2016 Arnold Sommerfeld-Prize of the Bavarian Academy of Sciences 2016 Dozentenpreis of the Chemical Industry Fund, 2016 ORCHEM Prize of the German Chemical Society (GDCH 2016 ADUC Prize of the German Chemical Society (GDCH Extramural Research Funding Foundation of the German Chemical Industry (FCI) “Sachkostenzuschuss” (2016) DFG Emmy Noether Grant (2013–2017) DFG SFB TRR 152 (2014–2018) DFG SFB 152 (2015–2018) European Commission ERC Starting Grant (2017–2021) Publications – Scientific Papers De Novo Synthesis of Benzannelated Heterocycles. J. Feierfeil, T. Magau-er*, Chem. Eur. J., 2017, DOI: 10.1002/chem.201705662.

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A Modular Synthesis of Tetracyclic Meroterpenoid Antibiotics. R. Wildermuth, K. Speck, F.-L. Haut, P. Mayer, B. Karge, M. Brönstrup, T. Magauer*, Nat. Commun. 2017, 8, 2083. Development of a β-C–H Bromination Approach Towards the Synthesis of Jeran-tinine E. T. Huber, T. Unzner, C. Gerlinger, T. Magauer*, J. Org. Chem., 2017, 82, 7410−7419. Dyotropic Rearrangements in Natural Product Synthesis and Biosynthesis. C. L. Hugelshofer, T. Magauer*, Nat. Prod. Rep., 2017, 34, 228–234. Bioinspired Total Syntheses of Terpenoids. C. L. Hugelshofer, T. Magauer, Org. Biomol. Chem., 2017, 15, 12–16. Evolution of a Polyene Cyclization Cascade for the Total Synthesis of (–)-Cyclosmenospongine. K. Speck, T. Magauer*, Chem. Eur. J. 2017, 23, 1157–1165. Convergent Assembly of the Tetracyclic Meroterpenoid (–)-Cyclosmenospongine via a Non-Biomimetic Polyene Cyclization. K. Speck, R. Wildermuth, T. Magau-er*, Angew. Chem., Int. Ed. 2016, 55, 14131–14135. A Divergent Approach to the Marine Diterpenoids (+)-Dictyoxetane and (+)-Dolabellane V. C. L. Hugelshofer, T. Magauer*, Chem. Eur. J. 2016, 22, 15125–15136. Rapid Access to Orthogonally Functionalized Naphthalenes: Application to the To-tal Synthesis of the Antitumor Agent Chartarin. T. A. Unzner, A. S. Grossmann, T. Magauer*, Angew. Chem., Int. Ed. 2016, 55, 9763–9767. A Bioinspired Cyclization Sequence Enables the Asymmetric Total Synthesis of Dictyoxetane. C. L. Hugelhofer, T. Magauer*, J. Am. Chem. Soc. 2016, 138, 6420–6423. Gold(I)-Catalyzed Enyne Cyclizations: Studies Towards the Total Synthesis of (+)-Aureol. R. Wildermuth, K. Speck, T. Magauer*, Synthesis 2016, 48, 1814–1824. Trihaloethenes as Versatile Building Blocks for Organic Synthesis. A. Grossmann, T. Magauer*, Org. Biomol. Chem., 2016, 14, 5377–5389. Other Activities Reviewer for Wiley VCH; ACS, Thieme, Elsevier, Beilstein

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Organic Chemistry Prof. Dr. rer. nat. Herbert Mayr Born 1947 in Weilheim/Oberbayern; 1966-1974 study of chemistry at LMU Mün-chen, 1974 PhD degree in the group of Rolf Huisgen, LMU München; 1975-1976 Postdoctoral research associate with G. A. Olah, Case Western Reserve University, Cleveland, Ohio, USA; 1976-1984 research associate with P. v. R. Schleyer, Frie-drich-Alexander-Universität Erlangen-Nürnberg; 1980 Habilitation in Organic Chemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg; 1984-1991 C4-Professor for Chemistry, Universität zu Lübeck; 1991-1996 C4-Professor for Or-ganic Chemistry, Technische Universität Darmstadt; 1996-2015 C4-Professor for Organic Chemistry, LMU München; since 2015 Principal Investigator in SFB 749 at the LMU München; 1997-1998 Chairman of the Institut fuer Organische Chemie, LMU München; 1998-2000 Dean of the Faculty of Chemistry and Phar-macy, LMU München; 2000-2004 Head of the Organic Chemistry Division of the German Chemical Society (Liebig-Vereinigung für Organische Chemie, Fachgruppe der GDCh); 2004-2012 Chairman of the Review Board “Molecular Chemistry” of the German Research Foundation (Deutsche Forschungsge-meinschaft); 2007-2008 Director of the Department of Chemistry and Biochemis-try, LMU München; 2011-2013 Dean of the Faculty of Chemistry and Pharmacy, LMU München. Research Topics Quantification of Organic Reactivity, Theoretical Concepts of Organic Chemistry, Organic and Macromolecular Synthesis, Organocatalysis. Honors, Awards, Memberships Excellent PhD Supervisor Award by the Gesellschaft Chinesischer Chemiker und Chemieingenieure in Deutschland (2016). Honorary member of the Israel Chemical Society (2017). Guest Professorship Tsinghua University, Beijing (2017). Member of the Bavarian Academy of Sciences and of the German National Acad-emy of Sciences Leopoldina; Member of the Editorial Board of the Journal of Physical Organic Chemistry and of the DECHEMA-Arbeitsausschuss “Kinetik und Reaktionsmechanismen”.

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Extramural Research Funding DFG (German Research Council) SFB 749 “Konzertiertheit bei Organischen Reak-tionen”. Fellowships from Alexander von Humboldt Foundation (AvH) and China Scholar-ship Council (CSC) for postdoctoral fellows and doctoral students. Publications – Scientific Papers C. García-Ruiz, J. L.-Y. Chen, C. Sandford, K. Feeney, P. Lorenzo, G. Berionni, H. Mayr, V. K. Aggarwal, Stereospecific Allylic Functionalization: The Reactivity of Allylboronate Complexes with Electrophiles, J. Am. Chem. Soc. 2017, 139, 15324–15327. R. J. Mayer, T. Tokuyasu, P. Mayer, J. Gomar, S. Sabelle, B. Mennucci, H. Mayr, A. R. Ofial, Solvation Accounts for the Counter-Intuitive Nucleophilicity Ordering of Peroxide Anions, Angew. Chem. 2017, 129, 13463-13467; Angew. Chem. Int. Ed. 2017, 56, 13279-13282. D. S. Allgäuer, H. Jangra, H. Asahara, Z. Li, Q. Chen, H. Zipse, A. R. Ofial, H. Mayr, Quantification and Theoretical Analysis of the Electrophilicities of Michael Acceptors, J. Am. Chem. Soc. 2017, 139, 13318-13329. H. Mayr, Nachruf: George A. Olah, Nachr. Chem. 2017, 65, 582. H. Mayr, A. R. Ofial, Philicity, Fugality, and Equilibrium Constants: When Do Rate-Equilibrium Relationships Break Down? Pure Appl. Chem. 2017, 89, 729-744. Z. Li, Q. Chen, P. Mayer, H. Mayr, Nucleophilicity parameters of arylsulfonyl sub-stituted halomethyl anions, J. Org. Chem. 2017, 82, 2011-2017. Á. Puente, A. R. Ofial, H. Mayr, Nucleophilic Reactivities of Bisacceptor Substi-tuted Benzyl Anions, Eur. J. Org. Chem. 2017, 1196-1202. P. A. Byrne, S. Kobayashi, E.-U. Würthwein, J. Ammer, H. Mayr, Why are Vinyl Cations Sluggish Electrophiles? J. Am. Chem. Soc. 2017, 139, 1499-1511. Z. Zhang, A. Puente, F. Wang, M. Rahm, Y. Mei, H. Mayr, G. K. S. Prakash, On the Nucleophilicity of Persistent α-Monofluoromethide Anions, Angew. Chem. 2016, 128, 13037-13041; Angew. Chem. Int. Ed. 2016, 55, 12845-12848.

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P. A. Byrne, K. Karaghiosoff, H. Mayr, Ambident Reactivity of Acetyl- and Formyl-Stabilized Phosphonium Ylides, J. Am. Chem. Soc. 2016, 138, 11272-11281. N. F. Fine Nathel, L. A. Morrill, H. Mayr, N. K. Garg, Quantification of the Elec-trophilicity of Benzyne and Related Intermediates, J. Am. Chem. Soc. 2016, 138, 10402-10405. S. Chelli, K. Troshin, P. Mayer, S. Lakhdar, A. R. Ofial, H. Mayr, Nucleophilicity Parameters of Stabilized Iodonium Ylides for Characterizing their Synthetic Poten-tial, J. Am. Chem. Soc. 2016, 138, 10304-10313. A. Levens, F. An, M. Breugst, H. Mayr, D. W. Lupton, Influence of the N-substituents on the nucleophilicity and Lewis basicity of N-heterocyclic carbenes, Org. Lett. 2016, 18, 3566-3569. E. Follet, P. Mayer, H. Mayr, Lewis Acidities of Indol-3-ylmethylium Ions and In-trinsic Barriers of their Reactions with Phosphines and Pyridines. Eur. J. Org. Chem. 2016, 23, 4050-4058. G. Berionni, H. Kurouchi, L. Eisenburger, H. Mayr, Nucleophilicity of Alkyl Zir-conocene and Titanocene Precatalysts, and Kinetics of Activation by Carbenium Ions and by B(C6F5)3, Chem. Eur. J. 2016, 22, 11196-11200. G. Berionni, H. Kurouchi, L. Eisenburger, H. Mayr, Nucleophilicity of Alkyl Zir-conocene and Titanocene Precatalysts, and Kinetics of Activation by Carbenium Ions and by B(C6F5)3, Chem. Eur. J. 2016, 22, 11196-11200. H. Mayr, A. R. Ofial, Philicities, Fugalities, and Equilibrium Constants, Acc. Chem. Res. 2016, 49, 952-965. M. Breugst, H. Laub, H. Mayr, P. A. Byrne, S. Kobayashi, Quantification of the Nucleophilic Reactivity of Nicotine, J. Phys. Org. Chem. 2016, 29, 759 -767. Q. Chen, P. Mayer, H. Mayr, Ethenesulfonyl Fluoride (ESF): The Most Perfect Mi-chael Acceptor Ever Found? Angew. Chem. 2016, 128, 12854-12858; Angew. Chem. Int. Ed. 2016, 55, 12664-12667. Á. Puente, S. He, F. Corral-Bautista, A. R. Ofial, H. Mayr, Nucleophilic Reactivi-ties of 2-Substituted Malonates. Eur. J. Org. Chem. 2016, 1841-1848.

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Organic Chemistry Priv.-Doz. Dr.-Ing. Armin R. Ofial Born 1967 in Bensheim, 1986-1991 study of chemistry at Technical Univ. Darm-stadt, 1996 doctoral degree (Dr.-Ing.) in the group of Prof. Dr. Herbert Mayr Tech-nical Univ. Darmstadt, since 1997 LMU München, Nov./Dec. 2005 JSPS Post-doctoral fellowship for Foreign Researchers (short-term) for research with Prof. Dr. Shun-ichi Fukuzumi (Graduate School of Engineering, University of Osaka, Japan), since 2008 independent research on oxidative C–H-functionalization, 2013 habilita-tion and appointment as Privatdozent at LMU München Research Topics Direct functionalization of C-H bonds. Oxidative cross coupling reactions. Struc-ture-reactivity relationships for electrophiles and nucleophiles in polar organic re-actions. Honors, Awards, Memberships Member of Gesellschaft Deutscher Chemiker (Liebig-Vereinigung, AG Chemie in der Medizinerausbildung) Member of Münchner Chemische Gesellschaft Extramural Research Funding DFG (German Research Council), Collaborative Research Center 749: Dynamics and intermediates of molecular transformations L’Oréal Research & Innovation (Agreement C141202, 10/2015–03/2016) Publications – Scientific Papers Solvation Accounts for the Counter-Intuitive Nucleophilicity Ordering of Peroxide Anions. R. J. Mayer, T. Tokuyasu, P. Mayer, J. Gomar, S. Sabelle, B. Mennucci,* H. Mayr,* A. R. Ofial,* Angew. Chem. Int. Ed. 2017, 56, 13279–13282; Angew. Chem. 2017, 129, 13463–13467.

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Quantification and Theoretical Analysis of the Electrophilicities of Michael Accep-tors. D. S. Allgäuer, H. Jangra, H. Asahara, Z. Li, Q. Chen, H. Zipse,* A. R. Ofial,* H. Mayr,* J. Am. Chem. Soc. 2017, 139, 13318–13329. Nucleophilicities and Lewis Basicities of Sterically Hindered Pyridines. E. Follet, H. Zipse, S. Lakhdar, A. R. Ofial, G. Berionni, Synthesis 2017, 49, 3495–3504. Reactivity-Tuning in Frustrated Lewis Pairs: Nucleophilicity and Lewis Basicity of Sterically Hindered Phosphines. E. Follet, P. Mayer, D. S. Stephenson, A. R. Ofial, G. Berionni, Chem. Eur. J. 2017, 23, 7422–7427. Philicity, Fugality, and Equilibrium Constants: When Do Rate-Equilibrium Rela-tionships Break Down? H. Mayr, A. R. Ofial, Pure Appl. Chem. 2017, 89, 729–744. Nucleophilic Reactivities of Bis-Acceptor-Substituted Benzyl Anions. Á. Puente, A. R. Ofial, H. Mayr, Eur. J. Org. Chem. 2017, 1196–1202. Nucleophilicity Parameters of Stabilized Iodonium Ylides for Characterizing their Synthetic Potential. S. Chelli, K. Troshin, P. Mayer, S. Lakhdar, A. R. Ofial, H. Mayr, J. Am. Chem. Soc. 2016, 138, 10304–10313. Philicities, Fugalities, and Equilibrium Constants. H. Mayr, A. R. Ofial, Acc. Chem. Res. 2016, 49, 952–965. Nucleophilic Reactivities of 2-Substituted Malonates. Á. Puente, S. He, F. Corral-Bautista, A. R. Ofial, H. Mayr, Eur. J. Org. Chem. 2016, 1841–1848. Other Activities Reviewer for J. Org. Chem., Org. Lett., Chem. Eur. J., Asian J. Org. Chem., Eur. J. Org. Chem., J. Phys. Org. Chem., Adv. Synth. Catal., Synthesis, Chem. Sci., Org. Biomol. Chem., and Monatsh. Chem. Co-project leader of a web-based teaching platform for medical students (virtuelle Hochschule Bayern vhb, project 14-I-05-11Det1, ‘Chemie für Mediziner’).

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Organic Chemistry Prof. Dr. rer. nat. Oliver Trapp Born 1973 in Göppingen, 1993-1998 Undergraduate and graduate studies in Chem-istry at the Eberhard-Karls-University Tübingen, 1998 Diploma in Chemistry and Diploma-Thesis with Prof. Dr. V. Schurig, Institute of Organic Chemistry, Eber-hard-Karls-University Tübingen, 1998-2001 Fellow in the DFG Graduate College 'Chemistry in Interphases' at the University of Tübingen, 2001 PhD and Disserta-tion with Prof. Dr. V. Schurig, Institute of Organic Chemistry, Eberhard-Karls-University Tübingen, 2002-2004 Postdoctoral Fellow in the Group of Prof. Dr. R.N. Zare, Department of Chemistry, Stanford University, California, USA, 2004-2008 Emmy Noether Research Group Leader at the Max-Planck-Institut für Kohlenforschung, 2008-2016 Professor of Organic Chemistry (W3) at the Ruprecht-Karls-Universität Heidelberg, 2009 Habilitation at the Ruhr-Universität Bochum, 2012-2015 Department Chair of the Organisch-Chemisches Institut at the Ruprecht-Karls-Universität Heidelberg, 2015-2016 Project and Scientific Manager of the Catalysis Research Laboratory (CaRLa), Since 2015 Scientific Coordinator of the Heidelberg Initiative for the Origins of Life, Since 2015 Max-Planck-Fellow of the Max-Planck-Institute for Astronomy, Since 2016 Professor of Organic Chemistry (W3) at Ludwig-Maximilians-Universität München Research Topics Design and synthesis of self-amplifying enantioselective catalysts, Design and syn-thesis of stereochemically flexible ligands and catalysts and investigation of their properties, Prebiotic chemistry, Origins of Life, Development of novel multiplexing techniques for high-throughput analysis of catalytic reactions, Development of on-column reaction chromatography and electrophoresis, High-throughput screening of catalysts, High-throughput determination of kinetic and thermodynamic parame-ters of catalyzed reactions, Synthesis of novel (enantioselective) catalysts and lig-ands, Noble metal nanoparticles, Synthesis of (chiral) stationary phases for chroma-tographic separation, Synthesis and immobilization of supramolecular compounds, Enantioselective dynamic chromatography, Development of direct calculation methods for dynamic chromatography, Development of software tools: DCXplorer, RCXplorer, ChromWin. Honors, Awards, Memberships Holger Erdtman Lecture, KTH - Royal Institute of Technology, Stockholm, Sweden

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Extramural Research Funding MPG Fellow (Max-Planck-Society) “Origins of Life” BMBF Project “CO2Form“ Publications – Scientific Papers Schmidt A-C., Hermsen M., Rominger F., Dehn R., Teles JH., Schäfer A., Trapp O., Schaub T. Synthesis of mono- and dinuclear vanadium complexes and their re-activity toward dehydroperoxidation of alkyl hydroperoxides. Inorg Chem 2017, 56, 1319-1332. Storch G., Haas M., Trapp O. Attracting enantiomers, chiral analytes that are simul-taneously shift reagents allow rapid screening of enantiomeric ratios by NMR spec-troscopy. Chem Eur J 2017, 23, 5414-5418. Storch G., Trapp O. By-design enantioselective self-amplification based on non-covalent product-catalyst interactions. Nature Chemistry 2017, 9, 179-187. Siebert M., Storch G., Rominger F., Trapp O. Temperature-controlled bidirectional enantioselectivity in asymmetric hydrogenation reactions utilizing stereodynamic iridium complexes. Synthesis 2017, 49, 3485-3494. Wunsch MR., Lehnig R., Trapp O. Online continuous trace process analytics using multiplexing gas chromatography. Anal Chem 2017, 89, 4038-4045. Germain N., Hermsen M., Schaub T., Trapp O. Synthesis of carbamates from car-bon dioxide promoted by organostannanes and alkoxysilanes. Appl Organomet Chem 2017, 31, e3733. Manzini S., Cadu A., Schmidt A-C., Huguet N., Trapp O., Paciello R., Schaub T. Enhanced activity and recyclability of palladium complexes in the catalytic synthe-sis of sodium acrylate from carbon dioxide and ethylene. ChemCatChem 2017, 9, 2269-2274.

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Manzini S., Huguet N., Trapp O., Paciello RA., Schaub T. Synthesis of acrylates from olefins and CO2 using sodium alkoxides as bases. Catal Today 2017, 281, 379-386. Siegle AF., Trapp O. Improving the signal-to-noise ratio in gel permeation chroma-tography by hadamard encoding. J Chromatogr A 2016, 1448, 93-97. Fischer F., Siegle AF., Checinski M., Fischer C., Kral K., Thede R., Trapp O., Hapke M. Synthesis of naphthylpyridines from unsymmetrical naphthylheptadiynes and the configurational stability of the biaryl axis. J Org Chem 2016, 81, 3087-3102. Storch G., Maier F., Wessig P., Trapp O. Rotational barriers of substituted biphep ligands, a comparative experimental and theoretical study. Eur J Org Chem 2016, 5123-5126. Storch G., Deberle L., Menke J-M., Rominger F., Trapp O. A stereodynamic phos-phoramidite ligand derived from 3,3'-functionalized ortho-biphenol and its rhodi-um(i) complex. Chirality 2016, 28, 744-748. Storch G., Pallmann S., Rominger F., Trapp O. Stereodynamic tetrahydro-biisoindole "nu-biphep(o)"s, functionalization, rotational barriers and non-covalent interactions. Beilstein J Org Chem 2016, 12, 1453-1458. Gallardo-Donaire J., Schelwies M., Ernst M., Trapp O., Schaub T. Direct synthesis of primary amines via Ru-catalyzed amination of ketones with ammonia and H2. Adv Synth Catal 2016, 358, 358-363. Gmeiner J., Seibicke M., Behrens S., Spliethoff B., Trapp O. Investigation of the hydrogenation of 5-methylfurfural by noble metal nanoparticles in a microcapillary reactor. ChemSusChem 2016, 6, 583-587. Gmeiner J., Behrens S., Spliethoff B., Trapp O. Ruthenium nanoparticles in high-throughput studies of chemoselective carbonyl hydrogenation reactions. Chem-CatChem 2016, 8, 571-576. Mormul J., Breitenfeld J., Trapp O., Paciello R., Schaub T., Hofmann P. Synthesis of adipic acid, 1,6-hexanediamine and 1,6-hexanediol via double n-selective hydro-formylation of 1,3-butadiene. ACS Catal 2016, 6, 2802-2810.

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Steflova J., Stefl M., Walz S., Knop M., Trapp O. Comprehensive study on critical micellar concentrations of SDS in acetonitrile-water solvents. Electrophoresis 2016, 37, 1287-1295. Zawatzky K., Lin M., Schafer W., Mao B., Trapp O., Welch CJ. Using chromato-gram averaging to improve quantitation of minor impurities. J Chromatogr A 2016, 1465, 205-210. Bailly L., Petit E., Maeno M., Shibata N., Trapp O., Cardinael P., Chataigner I., Cahard D. Enantiomerisation of allylic trifluoromethyl sulfoxides studied by HPLC analysis and DFTcalculations. Chirality 2016, 28, 136-142. Germain N., Hanauer M., Müller I., Paciello RA., Baumann R., Trapp O., Schaub T. Synthesis of industrially relevant carbamates in route to isocyanates using CO2 and organotin(iv) alkoxides. ChemSusChem 2016, 6, 1586-1590. Nakagawa N., Derrah EJ., Schelwies M., Rominger F., Trapp O., Schaub T. Tri-phos derivatives and diphosphines as ligands in the ruthenium-catalysed alcohol amination with NH3. Dalton Trans 2016, 45, 6856-6865. Trapp O., Zawatzky K. Synthesis of cryptochiral (r,r)-2,3-dideuterooxirane as ste-reochemical reference compound and chemical correlation with D-(+)-glyceraldehyde. Isr J Chem 2016, 56, 1082-1090. Patents Dehn R., Dehestani A., Massonne K., Wagloehner S., Teles JH., Schaub T., Brueg-gemann TC., Tellaeche Herranz C., Trapp O., Wysocki J. Method for producing c4-c15 lactams. PCT WO 2017133995, 2017. Schaub T., Paciello R., Ernst M., Mormul J., Breitenfeld J., Trapp O., Hofmann P. Hydroformylation process for producing 1,6-disubstituted hexane derivatives. PCT WO 2017064064, 2017. Schaub T., Paciello R., Huguet Subiela N., Trapp O., Manzini S. Process for pre-paring an unsaturated carboxylic acid salt. PCT WO 2017178282, 2017. Trapp O., Siegle AF. Chromatographic device and method. United States Patent US 2016/ 0195500 A1, 2016.

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Organic Chemistry Prof. Dr. phil. Hendrik Zipse Born 1962 in Heidelberg/Germany, 1982 - 1989 study of chemistry at Technical University Darmstadt, Germany, and University of Utah, Salt Lake City, USA; 1991 PhD degree in the group of Prof. Dr. Bernd Giese, Univ. Basel, Switzerland; 1992 - 1993, postdoctoral fellow with Prof. Dr. K. N. Houk, UCLA Los Angeles, USA; 1997 Habilitation at the Inst. Organic Chemistry, Technical University Ber-lin; since 1998 associate professor of chemistry at the Department of Chemistry, LMU München. Research Topics Development of new Lewis base catalysts for organocatalytic transformations such as esterifications, silylations, and C-C bond forming reactions; mechanistic studies of organocatalytic processes using combinations of spectroscopic and theoretical techniques; theoretical studies of radicals in enzymatic catalysis and oxidation reac-tions; development of new hydrogen donors for radical reactions. Extramural Research Funding "Investigations towards a permethrin rapid test", WIWeB. "Selective Silylation of Polyol Substrates", Xunta de Galicia, post-doctoral fellow-ship (24 months), to Dr. Marta Marin Luna. "Autoxidation of Alcohols", BASF SE. Focus program SPP 1807 "Control of London dispersion interactions" (German Re-search Council, DFG), project "Dispersion-guided Lewis base catalysis" Collaborative Research Center 749 "Dynamics and intermediates of molecular transformations" (German Research Council, DFG), project C06, "Radical stability in neutral and anionic systems"

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Publications – Scientific Papers D. S. Allgäuer, H. Jangra, H. Asahara, Z. Li, Q. Chen, H. Zipse, A. R. Ofial, H. Mayr, "Quantification and Theoretical Analysis of the Electrophilicities of Michael Acceptors", J. Am. Chem. Soc. 2017, 139, 13318 – 13329. F. Barth, F. Achrainer, A. M. Pütz, H. Zipse, "Aminopyridine-Borane Complexes as Hydrogen Atom Donor Reagents - Reaction Mechanism and Substrate Selectivi-ty", Chem. Eur. J. 2017, 23, 13455 - 13464. M. Balkenhohl, R. Greiner, I. S. Makarov, B. Heinz, K. Karaghiosoff, H. Zipse, P. Knochel, "Zn-, Mg-, and Li-TMP Bases for the Successive Regioselective Meta-lations of the 1,5-Naph-thyridine Scaffold (TMP=2,2,6,6- Tetramethyl-piperidyl)", Chem. Eur. J. 2017, 23, 13046 - 13050. L. Sandhiya, H. Zipse, "O-O Bond Homolysis in Hydrogen Peroxide", J. Comp. Chem. 2017, 2186 - 2192. M. A. Ganiek, M. R. Becker, G. Berionni, H. Zipse, P. Knochel, "Barbier Continu-ous Flow Preparation and Reactions of Carbamoyllithiums for Nucleophilic Ami-dation", Chem. Eur. J. 2017, 10280 - 10284. J. Helberg, M. Marin-Luna, H. Zipse, "Chemoselectivity in Esterification Reactions – Size Matters After All", Synthesis 2017, 49, 3460 - 3470. E. Follet, H. Zipse, S. Lakhdar, A. R. Ofial, G. Berionni, "Nucleophilicities and Lewis Basicities of Sterically Hindered Pyridines", Synthesis 2017, 49, 3495 - 3504. D. Sakic, H. Zipse, "Radical Stability as a Guideline in C–H Amination Reactions", Adv. Synth. Catal. 2016, 3983 - 3991. H. Jangra, M. H. Haindl, F. Achrainer, J. Hioe, R. M. Gschwind, H. Zipse, "Con-formational Preferences in Small Peptide Models: The Relevance of cis/trans-Conformations", Chem. Eur. J. 2016, 22, 13328 - 13335. M. Ellwart, I. S. Makarov, F. Achrainer, H. Zipse, P. Knochel, "Regioselective Transition-Metal-Free Allyl–Allyl Cross-Couplings", Angew. Chem. Int. Ed. 2016, 44, 10502 – 10506. U. Purushotham, H. Zipse, G. N. Sastry, "A first-principles investigation of histi-dine and its ionic counterparts", Theor. Chem. Acc. 2016, 135, 174:1 – 16.

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S. Becker, I. Thoma, A. Deutsch, T. Gehrke, P. Mayer, H. Zipse, T. Carell, "A high-yielding, strictly regioselective prebiotic purine nucleoside formation path-way", Science 2016, 352, 833 – 836. A. Ilangovan, P. Sakthivel, H. Zipse, "An Unusual Grob–type C–C/C-O Bond Cleavage of 5-Acyl-2,3-dihydro-4H-pyran-4-one Derivatives", Chem. Select 2016, 5, 1109 – 1116. R. Tandon, H. Zipse, "Anhydride Activation by 4-Dialkylaminopyridines and Ana-logs (n to .pi.*)", in Lewis Base Catalysis in Organic Synthesis (eds E. Vedejs and S. E. Denmark), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany, 2016. Other Activities Organizer, Undergraduate research conference on molecular sciences (URCUP17), 01.07. - 02.07.2017, Herrsching, Germany. Organizer, Undergraduate research conference on molecular sciences (URCUP16), 02.07. - 03.07.2016, Kloster Irsee, Germany.

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Physical Chemistry Prof. Dr. rer. nat. Thomas Bein Born 1954 in Toenning/Schleswig-Holstein, studies of chemistry at the University of Hamburg, Diploma in 1981. 1984 PhD degree at the University of Hamburg and Catholic University Leuven (Belgium). 1984-1986 Visiting Scientist at the DuPont Central Research and Development Department, Experimental Station (Wilming-ton, Delaware, USA). 1986-1991 Assistant Professor of Chemistry at the Universi-ty of New Mexico (Albuquerque, USA). 1991-1999 Associate and Full Professor at Purdue University (West Lafayette, Indiana, USA). Since 1999 Full Professor (C4) for Physical Chemistry at the LMU Munich. 2002-2003 and 2012-2014 Director of the Department of Chemistry at the LMU Munich. Research Topics Synthesis and characterization of functional nanostructures. Spectroscopy on func-tionalized surfaces, surface chemistry of thin films, surface growth of nanostruc-tures. Acoustic and optical sensors for molecular detection. Synthesis of porous materials with structure directing agents. Physical characteristics of nanostructured host-guest systems. Multifunctional porous nanoparticles for drug delivery. Nanostructured hybrid systems for photovoltaics and solar water splitting. Honors, Awards, Memberships ERC Advanced Grant “Electroactive Donor-Acceptor Covalent Organic Frameworks“ (ECOF) Coordinator of the Cluster of Excellence “Nanosystems Initiative Munich” (NIM) President of the International Mesostructured Materials Association (IMMA) Member of the American Chemical Society (ACS) Member of the Society of German Chemists (GDCh) Member of the Materials Research Society (MRS) Member of the Editorial Board Chemistry of Materials Member of the Editorial Board Microporous Materials Member of the Editorial Board Journal of Porous Materials Member of the Editorial Board Chemical Communications Member of the Editorial Board ACS Nano

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Extramural Research Funding European Research Council Advanced Grant: “Electroactive Donor-Acceptor Co-valent Organic Frameworks” (ECOF) Excellence Cluster: Nanosystems Initiative Munich NIM (DFG) Area 3 Collaborative Research Center 749: Dynamics and Intermediates of Molecular Transformations (DFG) Collaborative Research Center 1032: Nanoagents for Spatiotemporal Control of Molecular and Cellular Reactions (DFG) Priority Program SPP 1362: Porous Metal-Organic Frameworks (DFG) Priority Program SPP 1613: Regeneratively produced fuels by light driven water splitting: Investigation of involved elementary processes and perspectives of tech-nological implementation (DFG) Joint Research Project: Solar Technologies Go Hybrid (Bavarian Ministry for Sci-ence, Research and Arts) Project Network: Environmentally Friendly Contributions of Nanotechnology to-wards Sustainable Energy Conversion (Bavarian Ministry for Environment and Consumer Protection) Publications – Scientific Papers Auras, F; Ascherl, L.; Haldmioun, A. H.; Margraf J.; Hanusch, F.; Reuter, S.; Bes-singer D.; Döblinger M., Hettsedt, C.; Karaghiasoff, K.; Herbert, S.; Knochel, Paul, Clark, T.; Bein, T., Synchronized Offset Stacking: A Concept for Growing Large-Domain and Highly Crystalline 2D Covalent Organic Frameworks. Journal of the American Chemical Society 2016, 138 (51), 16703-16710. Oesinghaus, L.; Schlipf, J.; Giesbrecht, N.; Song, Lin; Hu, Y.; Bein, T.; Docampo, P.; Muller-Buschbaum, P., Toward Tailored Film Morphologies: The Origin of Crystal Orientation in Hybrid Perovskite Thin Films, Advanced Materials Interfac-es 2016, 3 (19), 1600403. Hufnagel, A. G.; Peters, K.; Muller, A.; Scheu, C.; Ng, Fattakhova-Rohlfing, D., Bein, T., Zinc Ferrite Photoanode Nanomorphologies with Favorable Kinetics for Water-Splitting, Advanced Functional Materials 2016, 26 (25), 4435-4443. Giesbrecht, N.; Schlipf, J.; Oesinghaus, L.; Binek, A.; Bein, T.; Muller-Buschbaum, P.; Docampo, P., Synthesis of Perfectly Oriented and Micrometer-Sized MAPbBr(3) Perovskite Crystals for Thin-Film Photovoltaic Applications, ACS Energy Letters 2016, 1 (1), 150-154.

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Fernandez, S.; Ganiek, M. A.; Karpacheva, M.; Hanusch, F.; Reuter, S.; Bein, T.; Auras, F., Knochel, P., Synthesis and Reactivity of Triazaphenanthrenes, Organic Letters 2016, 18 (13), 3158-3161. Rhauderwiek, T.; Waitschat, S.; Wuttke, S.; Reinsch, H.; Bein, T.; Stock, N., Na-noscale Synthesis of Two Porphyrin-Based MOFs with Gallium and Indium, Inor-ganic Chemistry 2016, 55 (11), 5312-5319. Hu, Y.; Schlipf, J.; Wussler, M.; Petrus, M. L.; Jaegermann, W.; Bein, T.; Muller-Buschbaum, P.; Docampo, P., ACS Nano 2016, 10 (6), 5999-6007. Weiss, V.; Argyo, C.; Torrano, A. A.; Strobel, C.; Mackowiak, SA; Schmidt. , A.; Muller; Gatzenmeier, T.; Hilger, I.; Brauchle, C.; Bein, T.; Dendronized mesopo-rous silica nanoparticles provide an internal endosomal escape mechanism for suc-cessful cytosolic drug release , Microporous and Mesoporous Materials 2016, 227, 242-251. Zimpel, A.; Preiss, T.; Roeder, R.; Engelke, H.; Ingrisch, M.; Peller, M.; Radler, JO; Wagner, E.; Bein, T.; Lachelt, U., Wuttke, S., Imparting Functionality to MOF Nanoparticles by External Surface Selective Covalent Attachment of Polymers, 2016, Chemistry of Materials, 28 (10), 3318-3326. Chiu, HY; Deng, W.; Engelke, H.; Helma, J.; Leonhardt, H; Bein, T., Intracellular chromobody delivery by mesoporous silica nanoparticles for antigen targeting and visualization in real time, Scientific Reports, 2016, 6, 25019. Datz, S.; Engelke, H.; Schirnding, C. V., Nguyen, L., Bein, T.; Lipid bilayer-coated curcumin-based mesoporous organosilica nanoparticles for cellular delivery, Mi-croporous and Mesoporous Materials 2016, 225, 371-377. Binek, A.; Grill, I.; Huber, N.; Peters, K., Hufnagel, AG, Handloser, M.; Docampo, P.; Hartschuh, A.; Bein, T.; Control of Perovskite Crystal Growth by Me-thylammonium Lead Chloride Templating, Chemistry – An Asian Journal 2016, 11 (8), 1199-1204. Nowald, C.; Penk, A.; Chiu, HY; Bein, T., Huster, D.; Lieleg, O., A Selective Mu-cin/Methylcellulose Hybrid Gel with Tailored Mechanical Properties Macromolecular Bioscience 2016, 16 (4), 567-579. Ascherl, L.; Sick, T.; Margraf, J T; Lapidus, SH; Calik, M.; Hettstedt, C.; Karaghi-osoff, K.; Döblinger, M.,Clark, T.; Chapmann, KW, Auras, F.; Bein, T., Molecular docking sites designed for the generation of highly crystalline covalent organic

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frameworks, Nature Chemistry 2016, 8 (4), 310-316. Schmidt, A.; Koestler, P.; Tambornino, F.; Bein, T., Efficient functionalization of mesoporous MCM-41 with aromatic organo-lithium reagents, Microporous and Mesoporous Materials 2016, 223, 219-224. Song, L.; Wang, W.; Koerstgens, V.; Gonzalez, D.M.; Yao., Y.; Minar, M.K.; Feckl, J.M.; Peters, K.; Bein, T.; Fattakhove-Rohlfing, D.; Santoro, G.; Roth, S.V., Mueller-Buschbaum, P., Spray Deposition of Titania Films with Incorporated Crys-talline Nanoparticles for All-Solid-State Dye-Sensitized Solar Cells Using P3HT . Advanced Functional Materials 2016, 26 (10), 1498-1506. Jumabekov, A. N.; Cordes, N.; Siegler, T. D.; Docampo, P.; Ivanova, A.; Fom-inykh, K.; Median, D.D.; Peter, L.M.; Bein, T., Passivation of PbS Quantum Dot Surface with L-Glutathione in Solid-State Quantum-Dot-Sensitized Solar Cells, ACS Applied Materials & Interfaces 2016, 8 (7) , 4600-4607. Kondofersky, I.; Müller, A.; Dunn, H. K.; Ivanova, A.; Štefanić, G.; Ehrensperger, M.; Scheu, C.; Parkinson, B. A.; Fattakhova-Rohlfing, D.; Bein, T., Nanostructured Ternary FeCrAl Oxide Photocathodes for Water Photoelectrolysis, Journal of the American Chemical Society 2016, 138 (6), 1860-1867. Calik, M.; Sick, T.; Dogru, M.; Döblinger, M.; Datz, S.; Budde, H.; Hartschuh, A.; Auras, F.; Bein, T., From Highly Crystalline to Outer Surface-Functionalized Covalent Organic Frameworks - A Modulation Approach, Journal of the American Chemical Society 2016, 138 (4), 1234-1239. Docampo, P.; Bein, T., A Long-Term View on Perovskite Optoelectronics, Accounts of Chemical Research 2016, 49 (2), 339-346. Handloser, K.; Giesbrecht, N.; Bein, T.; Docampo, P.; Handloser, M.; Hartschuh, A., Contactless Visualization of Fast Charge Carrier Diffusion in Hybrid Halide Perovskite Thin Films, ACS Photonics 2016, 3 (2), 255-261. Lohse, M. S.; Stassin, T.; Naudin, G.; Wuttke, S.; Ameloot, R.; De Vos, D.; Medina, D. D.; Bein, T., Sequential Pore Wall Modification in a Covalent Organic Framework for Application in Lactic Acid Adsorption, Chemistry of Materials 2016, 28 (2), 626-631.

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Castelló-Micó, A.; Herbert, S. A.; León, T.; Bein, T.; Knochel, P., Functionalizations of Mixtures of Regioisomeric Aryllithium Compounds by Selective Trapping with Dichlorozirconocene, Angewandte Chemie International Edition 2016, 55 (1), 401-404. Lohse, M. S.; Rotter, J. M.; Margraf, J. T.; Werner, V.; Becker, M.; Herbert, S.; Knochel, P.; Clark, T.; Bein, T.; Medina, D. D., From benzodithiophene to diethoxy-benzodithiophene covalent organic frameworks - structural investigations, CrystEngComm 2016, 18 (23), 4295-4302. van Rijt, S. H.; Bolukbas, D. A.; Argyo, C.; Wipplinger, K.; Naureen, M.; Datz, S.; Eickelberg, O.; Meiners, S.; Bein, T.; Schmid, O.; Stoeger, T., Applicability of avidin protein coated mesoporous silica nanoparticles as drug carriers in the lung, Nanoscale 2016, 8 (15), 8058-8069. Datz, S.; Argyo, C.; Gattner, M.; Weiss, V.; Brunner, K.; Bretzler, J.; von Schirnding, C.; Torrano, A. A.; Spada, F.; Vrabel, M.; Engelke, H.; Brauchle, C.; Carell, T.; Bein, T., Genetically designed biomolecular capping system for mesoporous silica nanoparticles enables receptor-mediated cell uptake and controlled drug release, Nanoscale 2016, 8 (15), 8101-8110. Möller, K.; Müller, K.; Engelke, H.; Brauchle, C.; Wagner, E.; Bein, T., Highly efficient siRNA delivery from core-shell mesoporous silica nanoparticles with multifunctional polymer caps, Nanoscale 2016, 8 (7), 4007-4019. Rühle, B.; Datz, S.; Argyo, C.; Bein, T.; Zink, J. I., A molecular nanocap activated by superparamagnetic heating for externally stimulated cargo release, Chemical Communications 2016, 52 (9), 1843-1846. Heidegger, S.; Go; Schmidt, A.; Niedermayer, S.; Argyo, C.; Endres, S.; Bein, T.; Bourquin, C., Immune response to functionalized mesoporous silica nanoparticles for targeted drug delivery, Nanoscale 2016, 8 (2), 938-948. Petrus, M.; Music, A.; Closs, A. C.; Bijleveld, J. C.; Sirtl, M. T.; Hu, Y.; Dingemans, T. J.; Bein, T.; Docampo, P., Design rules for the preparation of low-cost hole transporting materials for perovskite solar cells with moisture barrier properties, Journal of Materials Chemistry A 2017, 5 (48), 25200-25210. Greiner, R.; Ziegler, D. S.; Cibu, D.; Jakowetz, A. C.; Auras, F.; Bein, T.; Knochel, P., Preparation of Polyfunctional Naphthyridines by Cobalt-Catalyzed Cross-Couplings of Halogenated Naphthyridines with Magnesium and Zinc Organometallics, Organic Letters 2017, 19 (23), 6384-6387.

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Grill, I.; Aygüler, M. F.; Bein, T.; Docampo, P.; Hartmann, N. F.; Handloser, M.; Hartschuh, A., Charge Transport Limitations in Perovskite Solar Cells: The Effect of Charge Extraction Layers, ACS Applied Materials & Interfaces 2017, 9 (43), 37655-37661. Greul, E.; Petrus, M.; Binek, A.; Docampo, P.; Bein, T., Highly stable, phase pure Cs2AgBiBr6 double perovskite thin films for optoelectronic applications, Journal of Materials Chemistry A 2017, 5 (37), 19972-19981. Hu, Y.; Aygüler, M. F.; Petrus, M. L.; Bein, T.; Docampo, P., Impact of Rubidium and Cesium Cations on the Moisture Stability of Multiple-Cation Mixed-Halide Perovskites, ACS Energy Letters 2017, 2 (10), 2212-2218. Song, L.; Wang, W.; Pröller, S.; Moseguí González, D.; Schlipf, J.; Schaffer, C. J.; Peters, K.; Herzig, E. M.; Bernstorff, S.; Bein, T.; Fattakhova-Rohlfing, D.; Müller-Buschbaum, P., In Situ Study of Degradation in P3HT–Titania-Based Solid-State Dye-Sensitized Solar Cells, ACS Energy Letters 2017, 2 (5), 991-997. Fominykh, K.; Böhm, D.; Zhang, S.; Folger, A.; Döblinger, M.; Bein, T.; Scheu, C.; Fattakhova-Rohlfing, D., Nonagglomerated Iron Oxyhydroxide Akaganeite Nanocrystals Incorporating Extraordinary High Amounts of Different Dopants, Chemistry of Materials 2017, 29 (17), 7223-7233. Rager, S.; Dogru, M.; Werner, V.; Gavryushin, A.; Gotz, M.; Engelke, H.; Medina, D. D.; Knochel, P.; Bein, T., Pore wall fluorescence labeling of covalent organic frameworks, CrystEngComm 2017, 19 (33), 4886-4891. Song, L.; Wang, W.; Körstgens, V.; Moseguí González, D.; Löhrer, F. C.; Schaffer, C. J.; Schlipf, J.; Peters, K.; Bein, T.; Fattakhova-Rohlfing, D.; Roth, S. V.; Müller-Buschbaum, P., In situ study of spray deposited titania photoanodes for scalable fabrication of solid-state dye-sensitized solar cells, Nano Energy 2017, 40, 317-326. Bessinger, D.; Ascherl, L.; Auras, F.; Bein, T., Spectrally Switchable Photodetection with Near-Infrared-Absorbing Covalent Organic Frameworks, Journal of the American Chemical Society 2017, 139 (34), 12035-12042. Medina, D. D.; Sick, T.; Bein, T., Photoactive and Conducting Covalent Organic Frameworks, Advanced Energy Materials 2017, 7 (16), 1700387.

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Petrus, M. L.; Schlipf, J.; Li, C.; Gujar, T. P.; Giesbrecht, N.; Müller-Buschbaum, P.; Thelakkat, M.; Bein, T.; Hüttner, S.; Docampo, P., Capturing the Sun: A Review of the Challenges and Perspectives of Perovskite Solar Cells, Advanced Energy Materials 2017, 7 (16), 1700264. Chiu, H.-Y.; Leonhardt, H.; Bein, T., Synthesis and Functionalization of Ordered Large-Pore Mesoporous Silica Nanoparticles for Biomedical Applications, Chemie Ingenieur Technik 2017, 89 (7), 876-886. Grill, I.; Handloser, K.; Hanusch, F. C.; Giesbrecht, N.; Bein, T.; Docampo, P.; Handloser, M.; Hartschuh, A., Controlling crystal growth by chloride-assisted synthesis: Towards optimized charge transport in hybrid halide perovskites, Solar Energy Materials and Solar Cells 2017, 166, 269-275. Keller, N.; Bessinger, D.; Reuter, S.; Calik, M.; Ascherl, L.; Hanusch, F. C.; Auras, F.; Bein, T., Oligothiophene-Bridged Conjugated Covalent Organic Frameworks, Journal of the American Chemical Society 2017, 139 (24), 8194-8199. Medina, D. D.; Petrus, M. L.; Jumabekov, A. N.; Margraf, J. T.; Weinberger, S.; Rotter, J. M.; Clark, T.; Bein, T., Directional Charge-Carrier Transport in Oriented Benzodithiophene Covalent Organic Framework Thin Films, ACS Nano 2017, 11 (3), 2706-2713. Fominykh, K.; Tok, G. C.; Zeller, P.; Hajiyani, H.; Miller, T.; Döblinger, M.; Pentcheva, R.; Bein, T.; Fattakhova-Rohlfing, D., Rock Salt Ni/Co Oxides with Unusual Nanoscale-Stabilized Composition as Water Splitting Electrocatalysts, Advanced Functional Materials 2017, 27 (8), 1605121. Röder, R.; Preiß, T.; Hirschle, P.; Steinborn, B.; Zimpel, A.; Höhn, M.; Rädler, J. O.; Bein, T.; Wagner, E.; Wuttke, S.; Lächelt, U., Multifunctional Nanoparticles by Coordinative Self-Assembly of His-Tagged Units with Metal–Organic Frameworks, Journal of the American Chemical Society 2017, 139 (6), 2359-2386. Stassin, T.; Reinsch, H.; Van de Voorde, B.; Wuttke, S.; Medina, D. D.; Stock, N.; Bein, T.; Ameloot, R.; De Vos, D., Adsorption and Reactive Desorption on Metal–Organic Frameworks: A Direct Strategy for Lactic Acid Recovery, ChemSusChem 2017, 10 (3), 643-650. Möller, K.; Bein, T., Talented Mesoporous Silica Nanoparticles, Chemistry of Materials 2017, 29 (1), 371-388.

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Frank, A.; Wochnik, A. S.; Bein, T.; Scheu, C., A biomolecule-assisted, cost-efficient route for growing tunable CuInS2 films for green energy application, RSC Advances 2017, 7 (33), 20219-20230. Alexander, M.; Ilina, K.; Alena, F.; Dina, F.-R.; Thomas, B.; Christina, S., Dual absorber Fe 2 O 3 /WO 3 host-guest architectures for improved charge generation and transfer in photoelectrochemical applications, Materials Research Express 2017, 4 (1), 016409. Wuttke, S.; Zimpel, A.; Bein, T.; Braig, S.; Stoiber, K.; Vollmar, A.; Müller, D.; Haastert-Talini, K.; Schaeske, J.; Stiesch, M.; Zahn, G.; Mohmeyer, A.; Behrens, P.; Eickelberg, O.; Bölükbas, D. A.; Meiners, S., Validating Metal-Organic Framework Nanoparticles for Their Nanosafety in Diverse Biomedical Applications, Advanced Healthcare Materials 2017, 6 (2), 1600818. Other Activities Co-founder and Board Member of NanoScape AG, Area Coordinator of NIM Re-search Cluster (Nanosystems Initiative Munich), Board Member of the Center for NanoScience Munich (CeNS), Coordinator of the Master Program “Advanced Ma-terials Science” (AMS).

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Physical Chemistry Prof. Dr. rer. nat. Christoph Bräuchle Born 1947 in Metzingen/Württemberg, study of chemistry and physics at TU Berlin and at Univ. Tübingen, 1973 diploma in chemistry, 1978 PhD degree in Physical Chemistry at LMU Munich, 1979/80 Postdoctoral fellow at IBM Research San José (USA), 1982 habilitation, 1984 C2-professor at LMU Munich, 1986 call C3-professorship Physical Chemistry Univ. Mainz, 1986 call C4-professorship Physi-cal Chemistry TU Berlin, 1988 call C4-professorship Physical Chemistry LMU Munich, 1994 call C4-professorship Physical Chemistry, Director NMI/Univ. Tü-bingen, 1992 guest professorship at Univ. of California, Los Angeles (USA), 1994 guest professorship at Univ. Paris (France), 1993-1997 Vice Dean and Dean of the Faculty for Chemistry and Pharmacy, 1998-2000 member of the senate, LMU Mu-nich, 2000-2006 Head of the Center for Nanoscience (CeNS) at LMU Munich, 2004/2005 Chairman of the Department of Chemistry, LMU Munich, 2004-2012 Speaker and Vice Speaker of the International Elite Graduate School "Nano-Bio-Technology", 2006-2017 coordinator in the Excellence Clusters "Nanosystems Ini-tiative Munich" (NIM) and "Center for Integrated Protein Science" (CIPSM), 2008-2012 Member of the DFG Review Board for Science (Physical Chemistry), 2000-2014 Member of the Editorial Board ChemPhysChem – A European Journal of Chemical Physics and Physical Chemistry Research Topics Fluorescence live cell imaging and single virus tracing: observation of the infec-tion pathway of a single virus into a living cell and production (self-assembly and budding) of viruses in infected cells for HIV and Herpes Dynamics of single molecules in nanoporous systems: mechanistical studies of translation, rotation, adsorption and spectral diffusion of single molecules in meso-porous silica structures and other nanoporous systems Development of smart drug delivery systems/nanomedicine: drug delivery with mesoporous silica nanoparticles, polyplexes and lipoplexes/targeting, controlled release and depot effect, live cell imaging of uptake and trafficking in living cells Nanoparticles and human health: live cell imaging of uptake and trafficking of na-noparticles (SiO2, TiO2, ZnO, CeO, Pt etc.) in endothelial cells in an artificial blood circulation model and toxicity measurements

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Honors, Awards, Memberships Elected Member of the Bavarian Academy of Sciences Elected Member of the Academia Europaea Board of Trustees of "Deutsches Museum Munich" Gesellschaft Deutscher Chemiker Deutsche Physikalische Gesellschaft Deutsche Bunsen-Gesellschaft American Chemical Society Materials Research Society Biophysical Society Extramural Research Funding Excellence Cluster "Nanosystems Initiative Munich" (DFG and the Federal Minis-try of Education and Research) Third-party funds "Visualization of EPO-Receptor Interaction in Living Cells - A Feasibility Study" (Roche) Third-party funds "Siloxane Single Molecule Force Spectroscopy" (Wacker-Chemie) Publications – Scientific Papers Raddaoui N.*, Stazzoni S.*, Möckl L., Viverge B., Geiger F., Engelke H., Bräuchle C., Carell T.* Dendrimer-Based Signal Amplification of Click-Labelled DNA in Situ. ChemBioChem 2017; 18, 1716-1720. Höppner S., Kinting S., Torrano A., Schindlbeck U., Bräuchle C., Zarbock R., Wittman T., Griese M. Quantification of volume and lipid filling of intracellular vesicles carrying the ABCA3 transporter. BBA - Molecular Cell Research 2017; 1864(12), 2330-2335. Bräuchle C. Spektromikroskopie für biologische Fragestellungen in der Physikali-schen Chemie, p. 85. Beitrag im Buch “Unendliche Weiten: Kreuz und quer durchs Chemie-Universum”. Eds.: T.K. Lindhorst, H-J.Quadbeck-Seeger, Gesellschaft Deutscher Chemiker. Wiley VCH Verlag GmbH (2017)

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Vater M., Möck L., Gormanns V., Schultz Fademrecht C., Mallmann A.M., Zie-gart-Sadowska K., Zaba M., Frevert M.L., Bräuchle C., Holsboer F., Rein T., Schmidt U., Kirmeier T.* New insights into the intracellular distribution pattern of cationic amphiphilic drugs. Scientific Reports 7 (2017), Article number 44277. Kolbe K., Möckl L., Sohst V., Brandenburg J., Engel R., Malm S., Bräuchle C., Holst O., Lindhorst T.K.*, Reiling N.* Azido pentoses: A New Tool to Efficiently Label Mycobacterium tuberculosis Clinical Isolates. ChemBioChem (2017), ChemBioChem 2017; 18, 1172–1176. This publication did win the cover picture of the issue Uhl B., Hirn S., Immler R., Mildner K., Möckl L., Sperandio M., Bräuchle C., Reichel C., Zeuschner D., Krombach F. The Endothelial Glycocalyx Controls In-teractions of Quantum Dots with the Endothelium and Their Translocation across the Blood−Tissue Border. ACS Nano, 11(2) (2017), 1498-1508. Möckl L., Hirn S., Torrano A.A., Uhl B., Bräuchle C., Krombach F. The Glyco-calyx Regulates the Uptake of Nanoparticles by Human Endothelial Cells In Vitro. Nanomedicine 2017; 12(3), 207-217. Sommer A.-K., Hermawan A., Mickler F.M., Ljepoja B., Knyazev P., Bräuchle C., Ullrich A., Wagner E., Roidl A. Salinomycin co-treatment enhances tamoxifen cy-totoxicity in luminal A breast tumor cells by facilitating lysosomal degradation of receptor tyrosine kinases. Oncotarget 2016; 7(31), 50461-50476. Möckl L., Fessele C., Despras G., Bräuchle C., Lindhorst T.K. En route from artifi-cial to natural: Evaluation of inhibitors of mannose-specific adhesion of E. coli un-der flow. Biochimica et Biophysica Acta, Biochimica et Biophysica Acta 2016; 1860, 2031-2036. Torrano A.A., Herrmann R., Strobel C., Rennhak M., Engelke H. Reller A., Hilger I., Wixforth A., Bräuchle C.* Cell Membrane Penetration and Mitochondrial Tar-geting by Platinum-Decorated Ceria Nanoparticles. Nanoscale 2016; 8, 13352-13367. Weiss V., Argyo C., Torrano A.A., Strobel C., Mackowiak S.A., Schmidt A., Datz S., Gatzenmeier T., Hilger I., Bräuchle C.*, Bein T.* Dendronized Mesoporous Sil-ica Nanoparticles Provide an Internal Endosomal Escape Mechanism for Successful Cytosolic Drug Release. Microporous and Mesoporous Materials 2016; 227, 242-251.

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Datz S., Argyo C., Gattner M.J., Weiss V., Brunner K., Bretzler J., von Schirnding C., Torrano A.A., Spada F., Vrabel M., Engelke H., Bräuchle C., Carell T., Bein T. Genetically designed biomolecular capping system for mesoporous silica nanopar-ticles enables receptor-mediated cell uptake and controlled drug release. Nanoscale 2016; 8, 8101-8110. Möller K. Müller K. Engelke H. Bräuchle C. Wagner E.*, Bein T.* Highly efficient siRNA delivery from core–shell mesoporous silica nanoparticles with multifunc-tional polymer caps. Nanoscale 2016; 8 4007-401 Möckl L., Lindhorst T.K.., Bräuchle C.* Artificial Formation and Tuning of Gly-coprotein Networks on Live Cell Membranes: A Single-Molecule Tracking Study. ChemPhysChem 2016; 17(6) 829-835 This publication did win the cover picture of the issue Möckl L., Müller A., Bräuchle C., Lindhorst T.K.* Switching first contact: photo-control of E. coli adhesion to human cells. Chem. Comm. 2016; 52 1254-1257

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Physical Chemistry Prof. Dr. rer. nat. Hubert Ebert Born 1955 in Ellwangen/Baden Württemberg, study of physics at Ludwig-Maximilians-University, Diploma 1982 at LMU Munich, PhD degree 1986 at LMU Munich (NMR Untersuchungen zur elektronischen Struktur metallischer Systeme – Theorie und Expe-riment), 1986-87 Postdoctoral fellow at University of Bristol, UK, 1987-93 Zentrale Forschung und Entwicklung, Siemens Erlangen, Habilitation 1990 LMU Munich (Hyperfeinwechselwirkung in komplexen Systemen und Einflüsse rela-tivistischer Effekte auf die magnetischen und optischen Eigenschaften von magneti-schen Festkörpern), since 1993 C3-professor LMU Munich. Research Topics Theoretical investigations on: hyperfine interaction in para- and ferromagnetic transition metal systems magneto-optical properties of transition metal compounds and layered systems magnetic X-ray dichroism phase stability of transition metal compounds transport properties of transition metal alloys and layered systems electronic structure of surfaces properties of free and deposited transition metal clusters photoemission of correlated solids time-resolved electron spectroscopy Honors, Awards, Memberships Deutsche Physikalische Gesellschaft. Member of the Editorial board of “Journal of Electron Spectroscopy and Related Phenomena” Extramural Research Funding BMBF, DESY 05K13WMA Verbundprojekt 05K2013 - 3D-Vielkanal Spindet: Entwicklung eines Vielkanal Vek-tor-Spinpolarimeters für den Messplatz Phoenexs bei BESSY II, Teilprojekt 2.

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BMBF, DESY, 05K16WMA Verbundprojekt 05K2016 – Spin-TOF: Messplatz mit angepasster Zeitstruktur für Spinfilter-Impulsmikroskop, Teilprojekt 2. DFG, EB 154/21-2 Theoretische und experimentelle Erkundung des Phasenraums der Systeme Cr-Sb und Cr-Sb-Te. DFG,EB 154/24-2 Dynamical Mean Field Approach with Predictive Power for Strongly Correlated Ma-terials; A self-consistent, relativistic implementation of the LSDA+DMFT method. DFG,EB 154/25-2 Spin-Caloric Transport (SpinCaT); Spin-dependent thermo-galvanic effects: Theory. DFG,EB 154/26-2 Topological Insulators: Materials - fundamental Properties - Devices; magnetisch do-tierte topologische Isolatoren: vom Grundzustand zur Dynamik. DFG,EB 154/32-1 Ursprung und Stabilität von hochspinpolarisierten Oberflächenresonanzen. DFG,EB 154/35-1 Nachweis von Spinströmen über den magnetischen zirkularen Dichroismus in der Röntgenabsorptionsspektroskopie. DFG, EB 154/36-1 Variationen der magnetischen und Transporteigenschaften zweidimensionaler Ver-bindungen durch Substitution. DFG, EB 154/37-1 Verallgemeinerung des Einschrittmodells der Photoemission auf der Grundlage des Keldysh Formalismus zur Beschreibung von zeitabhängigen Photoemissions-experimenten. DFG, SFB 689 über Univ. Regensburg Spinphänomene in reduzierten Dimensionen; Teilprojekt A09: Experimentelle und theoretische Untersuchungen von Spin-Nanostrukturen ausgehend von einzelnen Atomen. Teilprojekt C08: Spin-Hall Effekt in metallischen Heterostrukturen. DFG, SFB 1277 über Univ. Regensburg Emergente relativistische Effekte in der Kondensierten Materie: Von grundlegenden Aspekten zu elektronischer Funktionalität. Teilprojekt A02: Struktur und Leitfähig-keit der Oberflächen topologischer Isolatoren. MSNANO: GA-2012-317554 A multiple scattering computing platform for (Nano) materials. COST MP 1306-1 Modern Tools for Spectroscopy on Advances Materials: a European Modeling Plat-form.

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Publications – Scientific Papers R. Chimata, E. K. Delczeg-Czirjak, A. Szilva, R. Cardias, Y. O. Kvashnin, M. Pereiro, S. Mankovsky, H. Ebert, D. Thonig, B. Sanyal, A. B. Klautau und O. Eriksson: Magnetism and ultrafast magnetization dynamics of Co and CoMn alloys at finite temperature, Phys. Rev. B 95, 214417 (2017). K. Chadova, S. Mankovsky, J. Minár und H. Ebert: Impact of finite temperatures on the transport properties of Gd from first principles, Phys. Rev. B 95, 125109 (2017). G. Derondeau, F. Bisti, M. Kobayashi, J. Braun, H. Ebert, V. A. Rogalev, M. Shi, T. Schmitt, J. Ma, H. Ding, V. N. Strocov und J. Minár: Fermi surface and effective masses in photoemission response of the (Ba1-xKx)Fe2As2 superconductor, Scientific Reports 7, 8787 (2017). C. Datzer, A. Zumbülte, J. Braun, T. Förster, A. B. Schmidt, J. Mi, B. Iversen, P. Hofmann, J. Minár, H. Ebert, P. Krüger, M. Rohlfing und M. Donath: Unraveling the spin structure of unoccupied states in Bi2Se3, Phys. Rev. B 95, 115401 (2017). M. Fanciulli, H. Volfová, S. Muff, J. Braun, H. Ebert, J. Minár, U. Heinzmann und J. H. Dil: Spin Polarization and Attosecond Time Delay in Photoemission from Spin Degenerate States of Solids, Phys. Rev. Lett. 118, 067402 (2017). S. A. Khan, J. Minár, H. Ebert, P. Blaha und O. Šipr: Local environment effects in the magnetic properties and electronic structure of disordered FePt, Phys. Rev. B 95, 014408 (2017). S. Meyer, Y.-T. Chen, S. Wimmer, M. Althammer, T. Wimmer, R. Schlitz, S. Geprägs, H. Huebl, D. Ködderitzsch, H. Ebert, G. E. W. Bauer, R. Gross und S. T. B. Goennenwein: Observation of the spin Nernst effect, Nat Mater 16, 977 (2017). S. Mankovsky und H. Ebert: Accurate scheme to calculate the interatomic Dzyaloshinskii-Moriya interaction parameters, Phys. Rev. B 96, 104416 (2017). J. Minár, H. Ebert und L. Chioncel: A self-consistent, relativistic implementation of the LSDA+DMFT method, The European Physical Journal Special Topics 226, 2477–2498 (2017). S. Mangelsen, P. G. Naumov, O. I. Barkalov, S. A. Medvedev, W. Schnelle, M. Bobnar, S. Mankovsky, S. Polesya, C. Näther, H. Ebert und W. Bensch: Large nonsaturating magnetoresistance and pressure-induced phase transition in the layered semimetal HfTe2, Phys. Rev. B 96, 205148 (2017).

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S. Mankovsky, S. Polesya, K. Chadova, H. Ebert, J. B. Staunton, T. Gruenbaum, M. A. W. Schoen, C. H. Back, X. Z. Chen und C. Song: Temperature-dependent transport properties of FeRh, Phys. Rev. B 95, 155139 (2017). M. Regus, S. Polesya, G. Kuhn, S. Mankovsky, S. R. Bauers, D. C. Johnson, H. Ebert, and W. Bensch: Experimental and theoretical investigation of the chromium-vanadium-antimony system, Z. Kristallogr. 232, 235 (2017). V. Popescu, P. Kratzer, S. Wimmer und H. Ebert: Native defects in the Co2TiZ (Z=Si, Ge, Sn) full Heusler alloys: Formation and influence on the thermoelectric properties, Phys. Rev. B 96, 054443 (2017). M. Regus, S. Polesya, G. Kuhn, S. Mankovsky, S. R. Bauers, D. C. Johnson, H. Ebert und W. Bensch: Experimental and theoretical investigation of the chromium-vanadium-antimony system, Zeitschrift für Kristallographie - Crystalline Materials 232, 235–244 (2017). E. D. Schaefer, S. Borek, J. Braun, J. Minár, H. Ebert, K. Medjanik, D. Kutnyakhov, G. Schönhense und H.-J. Elmers: Vectorial spin polarization detection in multichannel spin-resolved photoemission spectroscopy using an Ir(001) imaging spin filter, Phys. Rev. B 95, 104423 (2017).

J. Sánchez-Barriga, M. Battiato, M. Krivenkov, E. Golias, A. Varykhalov, A. Romualdi, L. V. Yashina, J. Minár, O. Kornilov, H. Ebert, K. Held und J. Braun: Subpicosecond spin dynamics of excited states in the topological insulator Bi2Te3, Phys. Rev. B 95, 125405 (2017). G. Schönhense, K. Medjanik, S. Chernov, D. Kutnyakhov, O. Fedchenko, M. Ellguth, D. Vasilyev, A. Zaporozhchenko-Zymaková, D. Panzer, A. Oelsner, C. Tusche, B. Schönhense, J. Braun, J. Minár, H. Ebert, J. Viefhaus, W. Wurth und H. Elmers: Spin-filtered time-of-flight k-space microscopy of Ir – Towards the “complete” photoemission experiment, Ultramicroscopy 183, 19 (2017). S. Borek, J. Braun, J. Minár, D. Kutnyakhov, H.-J. Elmers, G. Schönhense und H. Ebert: Determination of surface and interface magnetic properties for the multiferroic heterostructure Co/BaTiO3 using SPLEED and ARPES, J. Phys.: Cond. Mat. 28, 436004 (2016). One step model description of HARPES: inclusion of disorder and temperature effects, J. Braun, J. Minár und H. Ebert : Kapitel 7, Springer Series in Surface Sciences Springer, Berlin (2016).

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J. Braun, R. Rausch, M. Potthoff und H. Ebert: One-step theory of two-photon photoemission, Phys. Rev. B 94, 125128 (2016). K. Chadova, D. Ködderitzsch, J. Minár, H. Ebert, J. Kiss, S. W. D'Souza, L. Wollmann, C. Felser und S. Chadov: Resonant impurity states in chemically disordered half-Heusler Dirac semimetals, Phys. Rev. B 93, 195102 (2016). S. P. Collins, D. Laundy, T. Connolley, G. van der Laan, F. Fabrizi, O. Janssen, M. J. Cooper, H. Ebert und S. Mankovsky: On the possibility of using X-ray Compton scattering to study magnetoelectrical properties of crystals, Acta Crystallographica Section A 72, 197 (2016). G. Derondeau, J. Braun, H. Ebert und J. Minár: Theoretical study on the anisotropic electronic structure of antiferromagnetic BaFe2As2 and Co-doped Ba(Fe1-xCox)2As2 as seen by angle-resolved photoemission, Phys. Rev. B 93, 144513 (2016). G. Derondeau, J. Minár und H. Ebert: Hyperfine fields in the BaFe2As2 family and their relation to the magnetic moment, Phys. Rev. B 94, 214508 (2016). H. Ebert, J. Braun, D. Ködderitzsch und S. Mankovsky: Fully relativistic multiple scattering calculations for general potentials, Phys. Rev. B 93, 075145 (2016). A. Kronenberg, J. Braun, J. Minár, H.-J. Elmers, D. Kutnyakhov, A. V. Zaporozhchenko, R. Wallauer, S. Chernov, K. Medjanik, G. Schönhense, M. Kläui, S. Chadov, H. Ebert und M. Jourdan: Dirac cone and pseudogapped density of states in the topological half-Heusler compound YPtBi, Phys. Rev. B 94, 161108 (2016). D. Kutnyakhov, S. Chernov, K. Medjanik, R. Wallauer, C. Tusche, M. Ellguth, S. A. Nepijko, M. Krivenkov, J. Braun, S. Borek, J. Minár, H. Ebert, H. J. Elmers und G. Schönhense: Spin texture of time-reversal symmetry invariant surface states on W(110), Scientific Reports 6, 29394 (2016). S. Mankovsky, S. Polesya, H. Ebert und W. Bensch: Electronic and magnetic properties of 2H-NbS2 intercalated by 3d transition metals, Phys. Rev. B 94, 184430 (2016). M. Obstbaum, M. Decker, A. K. Greitner, M. Haertinger, T. N. G. Meier, M. Kronseder, K. Chadova, S. Wimmer, D. Ködderitzsch, H. Ebert und C. H. Back: Tuning Spin Hall Angles by Alloying, Phys. Rev. Lett. 117, 167204 (2016). V. Potapkin, L. Dubrovinsky, I. Sergueev, M. Ekholm, I. Kantor, D. Bessas, E. Bykova, V. Prakapenka, R. P. Hermann, R. Rüffer, V. Cerantola, H. J. M. Jönsson, W. Olovsson, S. Mankovsky, H. Ebert und I. A. Abrikosov: Magnetic interactions

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in NiO at ultrahigh pressure, Phys. Rev. B 93, 201110 (2016). S. Polesya, S. Mankovsky, D. Ködderitzsch, J. Minár und H. Ebert: Finite-temperature magnetism of FeRh compounds, Phys. Rev. B 93, 024423 (2016). S. Polesya, S. Mankovsky, D. Ködderitzsch, W. Bensch und H. Ebert: Dzyaloshinskii–Moriya interactions and magnetic texture in Fe films deposited on transition-metal dichalcogenides, physica status solidi (RRL) – Rapid Research Letters 10, 218 (2016). J. Sánchez-Barriga, E. Golias, A. Varykhalov, J. Braun, L. V. Yashina, R. Schumann, J. Minár, H. Ebert, O. Kornilov und O. Rader: Ultrafast spin-polarization control of Dirac fermions in topological insulators, Phys. Rev. B 93, 155426 (2016). O. Šipr, J. Minár und H. Ebert: Influence of spin-orbit coupling on the magnetic dipole term Tα, Phys. Rev. B 94, 144406 (2016). O. Šipr, S. Mankovsky, S. Polesya, S. Bornemann, J. Minár und H. Ebert: Illustrative view on the magnetocrystalline anisotropy of adatoms and monolayers, Phys. Rev. B 93, 174409 (2016). J. Sánchez-Barriga, A. Varykhalov, G. Springholz, H. Steiner, R. Kirchschlager, G. Bauer, O. Caha, E. Schierle, E. Weschke, A. A. Ünal, S. Valencia, M. Dunst, J. Braun, H. Ebert, J. Minár, E. Golias, L. V. Yashina, A. Ney, V. Holý und O. Rader: Nonmagnetic band gap at the Dirac point of the magnetic topological insulator (Bi1-

xMnx)2Se3, Nature Commun. 7, 10559 (2016). M. Vondrácek, L. Cornils, J. Minár, J. Warmuth, M. Michiardi, C. Piamonteze, L. Barreto, J. A. Miwa, M. Bianchi, P. Hofmann, L. Zhou, A. Kamlapure, A. A. Khajetoorians, R. Wiesendanger, J.-L. Mi, B.-B. Iversen, S. Mankovsky, S. Borek, H. Ebert, M. Schüler, T. Wehling, J. Wiebe und J. Honolka: Nickel: The time-reversal symmetry conserving partner of iron on a chalcogenide topological insulator, Phys. Rev. B 94, 161114 (2016). Other Activities Co-founder and speaker of the ESF COST action “Modern Tools for Spectroscopy and Advanced Materials: a European Modelling Platform”.

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Physical Chemistry Dr. rer. nat. Hanna Engelke Born 1981 in Würzburg, 2000-2005 physics studies at Universität Bayreuth and University of Exeter, UK, 2010 PhD at LMU Munich with Prof. J. Rädler, 2010-2013 Postdoctoral Fellow at University of California, Berkeley, USA with Prof J. Liphardt, since 2013 Groupleader in Physical Chemistry at LMU Munich Research Topics Mechanobiology: cell-matrix interactions in the context of tumor invasion and shape formation of organoids; Nanoparticles for drug delivery purposes and their interactions with cells Extramural Research Funding DFG, SFB1032, project B11 Publications – Scientific Papers A.A. Torrano, R. Herrmann, C. Strobel, M. Rennhak, H. Engelke, A. Reller, I. Hilger, A. Wixforth, C. Bräuchle (2016) "Cell Membrane Penetration and Mito-chondrial Targeting by Platinum-Decorated Ceria Nanoparticles", Nanoscale, 8, 13352-67 A. Zimpel, T. Preiß, R. Röder, H. Engelke, M. Ingrisch, M. Peller, J. O. Rädler, E. Wagner, T. Bein, U. Lächelt and S. Wuttke (2016) "Imparting Functionality to MOF Nanoparticles by External Surface Selective Covalent Attachment of Poly-mers", Chemistry of Materials, 28, 3318–3326 H.-Y. Chiu, W. Deng, H. Engelke, J. Helma, H. Leonhardt and T. Bein (2016) "In-tracellular chromobody delivery by mesoporous silica nanoparticles for antigen tar-geting and visualization in real time", Scientific Reports, 6, 25019 S. Datz, C. Argyo, M. J. Gattner, V. Weiss, K. Brunner, J. Bretzler, C. von Schirnding, A. A. Torrano, F. Spada, M. Vrabel, H. Engelke, C. Bräuchle, T. Carell and T. Bein (2016), "Genetically designed biomolecular capping system for meso-porous silica nanoparticles enables receptor-mediated cell uptake and controlled drug release", Nanoscale, 8, 8101-10

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K. Möller, K. Müller, H. Engelke, C. Bräuchle, E. Wagner and T. Bein (2016) "Highly Efficient siRNA Delivery from Core-Shell Mesoporous Silica Nanoparti-cles with Multifunctional Polymer Caps", Nanoscale, 8, 4007-4019 S. Datz, H. Engelke, C. von Schirnding, L. Nguyen and T. Bein (2016) "Lipid Bi-layer-Coated Curcumin-based Mesoporous Organosilica Nanoparticles for Cellular Delivery", Microporous & Mesoporous Materials, 225, 371-377 B. Illes, S. Wuttke*, H. Engelke*, (2017), "Liposome-Coated Iron Fumarate Metal-Organic Framework Nanoparticles for Combination Therapy", Nanomaterials, 7, 351 B. Illes, P. Hirschle, S. Barnert, V. Cauda, S. Wuttke*, and H. Engelke*, (2017), "Exosome-coated Metal-Organic Framework Nanoparticles: An Efficient Drug De-livery Platform", Chemistry of Materials, 29, 8042–804 B. Dumontel, M. Canta, H. Engelke, A. Chiodoni, L. Racca, A. Ancona, T. Limongi, G. Canavese, and V. Cauda, (2017), "Enhanced biostability and cellular uptake of zinc oxice nanocrystals shielded with a phospholipid bilayer", J. Mater. Chem. B, 5, 8799-8813 J. Mittag, B. Kneidl, T. Preiß, M. Hossann, G. Winter, S. Wuttke, H. Engelke*, J. Rädler*, (2017), "Impact of plasma protein binding on cargo release by thermosen-sitive liposomes probed by fluorescence correlation spectroscopy", Eur. J. Pharm. Biopharm., 119, 215-223 N. Raddaoui, S. Stazzoni, L. Möckl, B. Viverge, F. Geiger, H. Engelke, C. Bräuchle, T. Carell, (2017), "Dendrimer-Based Signal Amplification of Click-Labelled DNA in Situ", ChemBioChem, 18, 1716-1720 S. Rager, M. Dogru, V. Werner, A. Gavryushin, M. Götz, H. Engelke, D. D. Medi-na, P. Knochel and T. Bein (2017), "Pore wall fluorescence labeling of covalent organic frameworks", CrystalEngComm, 19, 4886-4891

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Physical Chemistry Prof. Dr. rer. nat. Achim Hartschuh Born in 1969 in Stuttgart, 1991-1993 study of physics at Univ. Tübingen, 1993-1996 study of physics at Univ. Stuttgart, 2001 PhD degree in the group of Prof. Dr. Hans-Christoph Wolf, Univ. Stuttgart, 2001-2002 Postdoctoral fellow in the group of Prof. Dr. Lukas Novotny at the Univ. of Rochester, USA, 2002-2005 Juniorpro-fessor at Univ. Siegen, 2005-2006 Juniorprofessor at Univ. Tübingen, since 2006 W2-Professor LMU München. Research Topics Development and application of novel optical methods for the characterization of single nanobjects at high spatial and temporal resolution. Extramural Research Funding Marie-Curie-Initial Training Network POCAONTAS ERC Starting Grant NEWNANOSPEC BMBF initiative, CISOVSKIT DFG Exzellenzcluster “Nanosystems Initiative Munich“ (NIM) DFG HA 4405/8-1, “Coherent Control of Plasmonic Hotspot Distributions in Nanoantennas” DFG HA 4405/9-1, Scientific meeting “International Conference on Enhanced Spectroscopies” (ICES) Bavarian initiative „Solar Technologies Go Hybrid (Soltech)” Publications – Scientific Papers Irene Grill, Meltem Aygüler, Thomas Bein, Pablo Docampo, Nicolai Hartmann, Matthias Handloser and Achim Hartschuh, "Charge transport limitations in perov-skite solar cells: The effect of charge extraction layers", ACS Applied Materials & Interfaces 9, 37655 (2017) Irene Grill, Kathrin Handloser, Fabian C Hanusch, Nadja Giesbrecht, Thomas Bein, Pablo Docampo, Matthias Handloser and Achim Hartschuh, "Controlling crystal growth by chloride-assisted synthesis: Towards optimized charge transport in hy-

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brid halide perovskites", Solar Energy Materials and Solar Cells 166, 269-275 (2017) Sriram Venkatesan, Tobia Mancabelli, Peter Krogstrup, Achim Hartschuh, Gerhard Dehme and Christina Scheu, "Surface optical phonon propagation in defect modu-lated nanowires", J. Appl. Phys. 121, 085702 (2017) Xian Shi, Nicolas Coca-Lopez, Julia Janik and Achim Hartschuh, "Advances in Tip-Enhanced Near-Field Raman Microscopy Using Nanoantennas", Chem. Rev. 117, 4945–4960 (2017) Sophia B. Betzler, Filip Podjaski, Michael Beetz, Kathrin Handloser, Andreas Wisnet, Matthias Handloser, Achim Hartschuh, Bettina V. Lotsch, and Christina Scheu, "Titanium Doping and Its Effect on the Morphology of Three-Dimensional Hierarchical Nb3O7(OH) Nanostructures for Enhanced Light-Induced Water Split-ting", Chem. Mater. 28, 7666 (2016) Andreas Binek, Irene Grill, Niklas Huber, Kristina Peters, Alexander G. Hufnagel, Matthias Handloser, Pablo Docampo, Achim Hartschuh, and Thomas Bein, "Control of Perovskite Crystal Growth by Methylammonium Lead Chloride Templating", Chem. Asian J. DOI: 10.1002/asia.201501379, (2016) M. Calik, T. Sick, M. Dogru, M. Döblinger, S. Datz, H. Budde, A. Hartschuh, F. Auras, T. Bein, "From Highly Crystalline to Outer Surface-Functionalized Cova-lent Organic Frameworks - A Modulation Approach", J. Am. Chem. Soc. 138, 1234 (2016) Alberto Comin, Richard Ciesielski, Nicolás Coca-López, Achim Hartschuh "Phase retrieval of ultrashort laser pulses using a MIIPS algorithm", Optics Express 24, 2505 (2016) Kathrin Handloser, Nadja Giesbrecht, Thomas Bein, Pablo Docampo, Matthias Handloser, Achim Hartschuh "Contact-less Visualization of Fast Charge Carrier Diffusion in Hybrid Halide Perovskite Thin Films", ACS Photonics 3, 255 (2016)

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Theoretical Chemistry Dr. rer. nat. Thomas-Christian Jagau Born 1986 in Frankfurt am Main; 2004–2009 study of chemistry at University of Mainz; 2009–2013 PhD in the group of Prof. Jürgen Gauß, University of Mainz; 2013–2015 postdoctoral fellow in the group of Prof. Anna Krylov at University of Southern California, Los Angeles, USA; 2015–2017 Liebig fellow at LMU Munich in the group of Prof. Christian Ochsenfeld; since 2017 leader of an Emmy Noether research group at LMU Munich. Research Topics Quantum-chemical methods for electronic resonances: Development and application of complex-variable coupled-cluster methods using complex absorbing potentials, complex scaling, and complex-scaled basis functions Characterization of autoionizing and Stark resonances beyond energies and lifetimes: Dyson orbitals, molecular properties, analytic gradients Interpretation and prediction of spectroscopic signatures of electronic resonances: photodetachment spectroscopy, electron energy loss (EEL) spectroscopy, electron transmission spectroscopy (ETS) Honors, Awards, Memberships Member of Arbeitsgemeinschaft Theoretische Chemie Member of German Chemical Society Member of Journal of Unsolved Questions e.V. Member of Young Center (CASY), Center of Advanced Studies, LMU Munich Extramural Research Funding Emmy Noether group “Non-Hermitian Quantum Mechanics in Electronic-Structure Theory” (DFG JA 2794/1-1) Liebig fellowship (Fonds der Chemischen Industrie)

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Publications – Scientific Papers Z. Benda, T.-C. Jagau, Analytic gradients for the complex absorbing potential equation-of-motion coupled-cluster method, J. Chem. Phys. 146, 031101/1-5 (2017). T.-C. Jagau, K. B. Bravaya, A. I. Krylov, Extending quantum chemistry of bound states to electronic resonances, Annu. Rev. Phys. Chem. 68, 525-553 (2017). T.-C. Jagau, Investigating tunnel and above-barrier ionization using complex-scaled coupled-cluster theory, J. Chem. Phys. 145, 204115/1-14 (2016). T.-C. Jagau, A. I. Krylov, Characterizing metastable states beyond energies and life–times: Dyson orbitals and transition dipole moments, J. Chem. Phys. 144, 054113/1-10 (2016). Other Activities Reviewer for Chemical Physics, International Journal of Quantum Chemistry, Journal of Chemical Physics, Journal of Physical Chemistry Member of the Scientific Organizing Committee of the 11th Triennial Congress of the World Association of Theoretical and Computational Chemists (WATOC 2017)

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Theoretical Chemistry Prof. Dr. rer. nat. Christian Ochsenfeld Born 1968 in Karlsruhe/Baden-Württemberg, 1986-1991 study of chemistry at Univ. Karlsruhe, 1994 PhD thesis in the group of Prof. Dr. Reinhart Ahlrichs, Univ. Karlsruhe, 1995-1998 Postdoctoral research at UC Berkeley, USA in the group of Prof. Dr. Martin Head-Gordon, 1998-2000 Liebig fellowship at Univ. Mainz, 2000-2002 leader of an Emmy Noether research group at Univ. Mainz, 2001 two offers for professor positions at the Universities Essen and Tübingen, 2002-2010 professor of Theoretical Chemistry at Univ. Tübingen, 2009 five offers for professor/chair positions at the Universities of Vienna (Austria), Berlin (FUB), Munich (LMU), Uppsala (Löwdin chair, Sweden), and Konstanz, since 2010 W3 professor of Theoretical Chemistry at LMU Munich. Research Topics Quantum Chemistry (method developments and study of molecular systems). Development and application of linear- and sublinear scaling methods: Ab initio methods for large molecules with 1000 and more atoms using Hartree-Fock (HF), Density-Functional Theory (DFT), Moller-Plesset Perturbation Theory (MP2), symmetry-adapted perturbation theory (SAPT) for the direct calculation of intermolecular interactions, and the Random Phase Approximation (RPA). Special focus also on the computation of molecular properties for large systems with more than 1000 atoms: e.g., NMR chemical shifts, dynamic polarizabilities, hyperpolarizabilities, spin-spin coupling constants, hyperfine couplings, excited-state properties, and dynamics both in ground- and excited-states. Distance-including integral estimates for transformed and untransformed two-electron integrals (QQR estimates for efficient ab-initio methods). Combination of linear-scaling methods with MM approaches (QM/MM) using large QM spheres with more than 1000 atoms. Example applications include the quantum-chemical study of DNA repair processes, PYP dynamics, RNA polymerase and the study of photocatalysis by covalent organic frameworks (COFs).

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Honors, Awards, Memberships Member of the World Association of Theoretical and Computational Chemists (WATOC) Max-Planck-Fellow at MPI-FKF, Stuttgart, Germany Member of the “International Academy of Quantum Molecular Sciences” (IAQMS) Teaching Award 2016 at Bavarian Universities Deputy Director of the Department of Chemistry at LMU Munich Member of the Scientific Advisory Board of the IWR at the University of Heidelberg Speaker of the Arbeitsgemeinschaft Theoretische Chemie Member of the Hochschulrat at LMU Munich Member of Senate at LMU Munich Member of the Editorial Board of “Molecular Physics” Member of ProcessNet taskforce “kinetics and reaction mechanism” Member of German Chemical Society Member of American Chemical Society Member of German Bunsen-Society Member of Munich Chemical Society Extramural Research Funding Collaborative Research Center SFB 749 (DFG) SFB 749/3 2015 Excellence Cluster Center for Integrated Protein Sciences Munich (DFG and the Federal Ministry of Education and Research) – EXC 114 (CIPSM). Funding of Deutsche Forschungsgesellschaft, (DFG) OC 35/4-1, conference support OC 35/6-1 for WATOC 2017 Fonds der Chemischen Industrie (FCI) conference support Fellowships from Alexander von Humboldt Foundation, DFG for various postdocs, from Fonds der Chemischen Industrie (FCI) for two Liebig fellows. Publications – Scientific Papers M. Beuerle, C. Ochsenfeld, Short-Range Second Order Screened Exchange Correction to RPA Correlation Energies, J. Chem. Phys. 147, 204107 (2017). T. Banerjee, F. Haase, G. Savasci, K. Gottschling, C. Ochsenfeld, B. Lotsch, Single Site Photocatalytic H2 Evolution from Covalent Organic Frameworks with Molecular Cobaloxime Co-catalysts, J. Am. Chem. Soc. 139, 16228 (2017).

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L. D. M. Peters, J. Kussmann, C. Ochsenfeld, Efficient and Accurate Born-Oppenheimer Molecular Dynamics for Large Molecular Systems, J. Chem. Theory Comput.13, 5479 (2017). K. B. Moore, K. Sadeghian, C. D. Sherrill, C. Ochsenfeld, H. F. Schaefer, C−H···O Hydrogen Bonding. The Prototypical Methane-Formaldehyde System: A Critical Assessment, J. Chem. Theory Comput. 13, 5379 (2017). T. H. Thompson, C. Ochsenfeld, Distance-including rigorous upper bonds and tight estimates for two-electron integrals over long-and short-range operators, J. Chem. Phys, 147, 144101 (2017). S. Vogler, M. Ludwig, M. Maurer, C. Ochsenfeld, Low-scaling first-order properties within second-order Møller-Plesset perturbation theory using Cholesky decomposed density matrices, J. Chem. Phys., 147, 024101 (2017). J. Kussmann, C. Ochsenfeld, Hybrid CPU/GPU Integral Engine for Strong-Scaling Ab Initio Methods, J. Chem. Theory Comput. 13, 3153 (2017). H. Schurkus, A. Luenser, C. Ochsenfeld, Almost Error-Free Resolution-of-the Identity Correlation Methods By Null Space Removal Of The Particle-Hole Interactions, J. Chem.Phys., 146, 211106 (2017). J. Kussmann, C. Ochsenfeld, Employing OpenCL to Accelerate Ab Initio Calculations on Graphics Processing Units, J. Chem. Theory Comput, 13, 2712 (2017). C. Siebler, J. Egli, B. Maryasin, R. S. Erdmann, C. Bergande, C. Ochsenfeld, H. Wennemers, pH-Responsive Aminoproline-Containing Collagen Triple Helices, Chem. Eur. J. 23, 7938 (2017). D. Sundholm, M. Rauhalahti, N. Özcan, R. Mera-Adasme, J. Kussmann, A. Luenser, C. Ochsenfeld, Nuclear magnetic shieldings of stacked aromatic and antiaromatic molecules, J. Chem. Theory Comput., 13, 1952 (2017). M. Beuerle, J. Kussmann, C. Ochsenfeld, Screening Methods for Linear-Scaling Short-Range Hybrid Calculations on CPU and GPU Architectures, J. Chem. Phys., 146, 144108 (2017).

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S. Rossbach, C. Ochsenfeld, Quantum-chemical study of the discrimination against dNTP in the nucleotide addition reaction in the active site of RNA Polymerase II, J. Chem. Theory Comput., 13, 1699 (2017). F. Haase, T. Banerjee, G. Savasci, C. Ochsenfeld, B. V. Lotsch, Structure-property-activity relationships in a pyridine containing azine-linked covalent organic framework for photocatalytic hydrogen evolution, Farad. Discuss., 201, 247 (2017). A. Luenser, H. F. Schurkus, C. Ochsenfeld, Vanishing Overhead Linear Scaling Random Phase Approximation by Cholesky Decomposition and an Attenuated Coulomb-Metric, J. Chem. Theory Comput., 13, 1647 (2017). S. Rossbach, C. Ochsenfeld, Influence of coupling and embedding schemes on the QM size convergence in QM/MM approaches for the example of a proton transfer in DNA, J. Chem. Theory Comput., 13, 1102(2017). R. Mera-Adasme, H. Erdmann, T. Berezniak, C. Ochsenfeld, Destabilization of the metal site as a hub for the pathogenic mechanism of five ALS-linked mutants of copper, zinc superoxide dismutase, Metallomics, 8, 1141 (2016). P. J. Taenzler, K. Sadeghian, C. Ochsenfeld, A dynamic equilibrium of three hydrogen-bond conformers explains the NMR spectrum of the active site of photoactive yellow protein, J. Chem. Theorey Comput. 12, 5170 (2016). A. Luenser, J. Kussmann, C. Ochsenfeld, Computation of indirect nuclear spin-spin couplings with reduced complexity in pure and hybrid density functional approximations, J. Chem. Phys. 145, 124103(2016). V. S. Vyas, M. Viswakarma, I. Moudrakovski, F. Haase, G. Savasci, C. Ochsenfeld, J. P. Spatz, B. V. Lotsch, Exploiting non-covalent interactions in an imine-covalent organic framework for quercetin delivery, Adv. Mater. 28, 8749 (2016). J. Arras, K. Eichele, B. Maryasin, H. Schubert, C. Ochsenfeld, L. Wesemann, Intermolecular 119Sn, 31P through-space spin-spin coupling in a solid bivalent tin phosphido complex, Inorg. Chem. 55, 4669 (2016). H. F. Schurkus, C. Ochsenfeld, An Effective Linear-Scaling Atomic-orbital Reformulation of the Random-Phase Approximation Using a Contracted Double-Laplace Transformation, J. Chem. Phys. 144, 031101 (2016).

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Other Activities Organisation of the WATOC 2017 conference in Munich with 1520 participants; Grant reviewer and/or panel member of the European Research Council, DFG, Norwegian Research Council, Vertrauensdozent of the Studienstiftung des Deutschen Volkes, Vertrauensdozent of the Max Weber Stiftung; Reviewer for Angewandte Chemie, Biopolymers, Chemical Physics, Chemical Physics Letters, Chemical Reviews, Chemical Science, Chemistry - A European Journal, Chem-PhysChem, Computation, Computational Molecular Science, International Journal of Quantum Chemistry, Journal of Chemical Physics, Journal of Chemical Theory & Computation, Journal of Collection of the Czechoslovak Chemical Communica-tions, Journal of Computational Chemistry, Journal of Computational Physics, Journal of Magnetic Resonance, Journal of Physical Chemistry, Journal of Physical Chemistry Letters, Journal of Structural Biology, Journal of the American Chemi-cal Society, Molecular Physics, Molecules, Phys. Chem. Chem. Phys., Physica B: Physics of Condensed Matter, Proc. Natl. Acad. Sci., Theoretical Chemistry Ac-counts, Zeitschrift für Physik D: Atoms, Molecules and Clusters.

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Physical Chemistry Prof. Dr. rer. nat. Philip Tinnefeld Born 1974 in Münster/Nordrhein-Westfalen, 2002 PhD in Physical Chemistry, University of Heidelberg, 2002/2003 Postdoc at UCLA (USA), University of Hei-delberg and University of Leuven (Belgium), 2003-2007 Single-Molecule Fluores-cence Group at University of Bielefeld, 2006 Habilitation in Physics, 2007-2010 Professor of Biophysics, LMU München, 2010-2017 Professor of Biophysical Chemistry, TU Braunschweig, since August 2017 Professor (chair) Department Chemistry, Ludwig-Maximilians-Universität München Research Topics Single-molecule spectroscopy of hybrid nanostructures and multichromophoric sys-tems: We study fundamental aspects of single-molecule photophysics including chromophore interactions with plasmonic nanostructures, for light harvesting and energy conversion. Single-molecule sensing: Based on DNA nanotechnology and novel molecular de-vices, we develop new approaches for e.g. biosensing, for sensing of forces be-tween molecules and for molecular voltage sensors. Single-Molecule and Superresolution Microscopy: We develop new superresolution methods including DNA PAINT; DNA origami nanorulers and tools for studying biomolecular machines including enzymes and transcription complexes, biomolecu-lar structures as well as conformational changes and other transformations. Honors, Awards, Memberships 24.11.2017: CeNS Publication Award 2017 for best interdisciplinary publication in Science 2016, 354(6310), 305-307. 03.11.2017: Technologietransferpreis 2017 of the IHK Braunschweig for the Spin-Off of GATTAquant GmbH, first commercial application of DNA origami. August 2017: accepted Call W3-professorship (chair) Physical Chemistry, Depart-ment Chemistry, Ludwig-Maximilians-Universität München Gesellschaft Deutscher Chemiker Deutsche Bunsen-Gesellschaft, Center for NanoScience Munich

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Extramural Research Funding Excellence Cluster "Nanosystems Initiative Munich" (DFG and the Federal Minis-try of Education and Research) Excellence Cluster "Center for Integrated Protein Science Munich" (DFG and the Federal Ministry of Education and Research) BMBF-Project VIP+ "Signal-Booster für Fluoreszenz-Assays in der Molekularen Diagnostik (SiBoF, 03VP03891)", Koordination und Teilprojekt Molekulare Si-gnalgeneration und plasmonische Signalverstärkung BMBF-Projekt, wivorpro „Point-of-Care-Diagnostik mit Einzelmolekül-Nachweis“ (Pocemon 13N14336) EU-Project "Overcoming the Limits of Diffraction with Superresolution Lighting on a Chip (ChipScope, 737089)" DFG-grant TI 329/10-1 "Optical Voltage Sensing Nano-Devices using DNA Self-Assembly" Publications – Scientific Papers Pilo-Pais M., Acuna G.P., Tinnefeld P., Liedl T. Sculpting light by arranging opti-cal components with DNA nanostructures, MRS Bulletin 42(12) (2017), 936-942. Ochmann S., Vietz C., Trofymchuk K., Acuna G., Lalkens B., Tinnefeld P. An Op-tical Nanoantenna for Single Molecule-Based Detection of Zika Virus Nucleic Ac-ids without Molecular Multiplication, Analytical Chemistry (2017), DOI: 10.1021/acs.analchem.7b04082 Vietz C., Acuna G.P., Lalkens B., Tinnefeld P. Synergistic Combination of Un-quenching and Plasmonic Fluorescence Enhancement in Fluorogenic Nucleic Acid Hybridization Probes. Nano Lett. 2017; 17(10), 6496–6500. Acuna G.P., Tinnefeld P. Molecule detection with sunlight. Nature Photonics 11, (2017) 616-618.

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Theoretical Chemistry Prof. Dr. rer. nat. Regina de Vivie-Riedle Regina de Vivie-Riedle was born 1958 in Wuppertal, Germany. She graduated in chemistry from the Friedrich-Wilhelm-Universität Bonn, Germany, in 1987. In 1997, she did her Habilitation in Theoretical Chemistry at the Freie Universität Berlin. She did two postdocs, one at the Max Planck Institute of Quantum Optics (MPQ) in Garching and one at the Joint Institute for Laboratory Astrophysics (JILA) in Boulder. From 1997 to 2002 she was a C3 professor at the MPQ. Since 2003, she has been the leader of the theoretical femtoscience group at the Ludwig-Maximilians-Universität München, since November 2013 Dean of Studies. Research Topics Femtochemistry: Ultrafast uni- and bimolecular reactions in chemistry and biology studied by quantum dynamics (QD) and on-the-fly dynamics. Optimal Control Theory: Design of optimal light fields to control chemical reactions and molecular processes for molecular electronics and quantum information. Electron dynamics: Steering of electron motion to control chemical reactions. Method development: efficient propagation schemes for reactive quantum dynamics in large molecules, QD/MD algorithms for condensed phase simulations. Honors, Awards, Memberships Member of the German Physical Society Member of the German Bunsen Society Member of the Association of the Theorecal Chemistry Extramural Research Funding Excellence Cluster Munich Centre for Advanced Photonics (DFG and the Federal Ministry of Education and Research) Collaborative Research Center 749 (German Research Council) “Dynamics and intermediates of molecular transformations”

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Publications – Scientific Papers T. Schnappinger, P. Kölle, M. Marazzi, A. Monari, L. Gonzalez, and R. de Vivie-Riedle, Ab initio molecular dynamics of thiophene: The interplay of internal con-version and intersystem crossing, Phys. Chem. Chem. Phys. 19 (2017), 25662-25670. H. Li, X. Gong, K. Lin, R. de Vivie-Riedle, X. Tong, J. Wu, and M. F. Kling Sub-cycle directional control of the dissociative ionization of H2 in tailored femto-second laser fields, J. Phys. B: At., Mol. Opt. Phys. 50 (2017), 172001. H. Li, N. G. Kling, T. Gaumnitz, C. Burger, R. Siemering, J. Schötz, Q. Liu, L. Ban, Y. Pertot, J. Wu, A. M. Azzeer, R. de Vivie-Riedle, H. J. Wörner, and M. F. Kling, Sub-cycle steering of the deprotonation of acetylene by intense few-cycle mid-infrared laser fields, Opt. Express 25 (2017), 14192. B. Jochim, R. Siemering, M. Zohrabi, O. Voznyuk, J. B. Mahowald, D. G. Schmitz, K. J. Betsch, B. Berry, T. Severt, N. G. Kling, T. G. Burwitz, K. D. Carnes, M. F. Kling, I. Ben-Itzhak, E. Wells, and R. de Vivie-Riedle, The importance of Rydberg orbitals in dissociative ionization of small hydrocarbon molecules in intense laser fields, Sci. Rep. 7, Article number: 4441 (2017). M. Kübel, C. Burger, R. Siemering, N. G. Kling, B. Bergues, A. S. Alnaser, I. Ben-Itzhak, R. Moshammer, R. de Vivie-Riedle and M. F. Kling, Phase- and intensity-dependence of ultrafast dynamics in hydrocarbon molecules in few-cycle laser fields, Mol. Phys. 115 (2017), 1835-1845. E. Riedle, M. K. Roos, S. Thallmair, C. F. Sailer, N. Krebs, B. P. Fingerhut, and R. de Vivie-Riedle, Ultrafast photochemistry with two product channels: wavepacket motion through two distinct conical intersections, Chem. Phys. Lett. 683 (2017), 128-134. D. Keefer, S. Thallmair, S. Matsika, and R. de Vivie-Riedle, Controlling Photore-laxation in Uracil with Shaped Laser Pulses: A Theoretical Assessment, J. Am. Chem. Soc. 139 (2017), 5061-5066. S. Thallmair, D. Keefer, F. Rott, and R. de Vivie-Riedle, Simulating the control of molecular reactions via modulated light fields: From gas phase to solution, J. Phys. B: At., Mol. Opt. Phys. 50 (2017), 082001. S. Oesterling, O. Schalk, T. Geng, R. D. Thomas, T. Hansson, and R. de Vivie-Riedle, Substituent effects on the relaxation dynamics of furan, furfural and β-

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furfural: a combined theoretical and experimental approach, Phys. Chem. Chem. Phys. 19 (2017), 2025-2035. B. S. Matsuura, P. Kölle, D. Trauner, R. de Vivie-Riedle, and R. Meier, Unravel-ling Photochemical Relationships Among Natural Products from Aplysia dacty-lomela, ACS Cent. Sci. 3 (2017), 39-46. F. Nicoli, M. K. Roos, E. A. Hemmig, M. Di Antonio, R. de Vivie-Riedle, and T. Liedl, Proximity-Induced H-Aggregation of Cyanine Dyes on DNA-Duplexes, J. Phys. Chem. A 120 (2016), 9941-9947. J. P. P. Zauleck, S. Thallmair, M. Loipersberger, and R. de Vivie-Riedle, Two new methods to generate internal coordinates for molecular wave packet dynamics in reduced dimensions, J. Chem. Theory Comput. 12 (2016), 5698-5708. D. Keefer, S. Thallmair, S. Matsika, and R. de Vivie-Riedle, How to Control the Ultrafast Dynamics of Uracil with Shaped Laser Pulses: Theoretical Insights, in: Ultrafast Phenomena XX, OSA Technical Digest (online) (Optical Society of America, 2016). D. Keefer, S. Thallmair, J. P. Zauleck, and R. de Vivie-Riedle, Optimal Control Theory for Molecular Reactions in Atomistic Surroundings, in: Ultrafast Phenome-na XX, OSA Technical Digest (online) (Optical Society of America, 2016). C. Burger, Nora G. Kling, R. Siemering, A. S. Alnaser, B. Bergues, A. M. Azzeer, R. Moshammer, R. de Vivie-Riedle, M. Kübel and M. Kling, Visualization of bond rearrangements in acetylene using near single-cycle laser pulses, Faraday Discuss. 194 (2016), 495-508. S. Thallmair, M. K. Roos, and R. de Vivie-Riedle, Design of specially adapted re-active coordinates to economically compute potential and kinetic energy operators including geometry relaxation, J. Chem. Phys. 144 (2016), 234104. M. Kübel, R. Siemering, C. Burger, Nora G. Kling, H. Li, A. S. Alnaser, B. Bergues, S. Zherebtsov, A. M. Azzeer, I. Ben-Itzhak, R. Moshammer, R. de Vivie-Riedle, and M. F. Kling, Steering Proton Migration in Hydrocarbons Using Intense Few-Cycle Laser Fields, Phys. Rev. Lett. 116 (2016), 193001. P. Kölle, T. Schnappinger, and R. de Vivie-Riedle, Deactivation pathways of thio-phene and oligothiophenes: internal conversion versus intersystem crossing, Phys. Chem. Chem. Phys. 18 (2016), 7903-7915.

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S. Thallmair, M. K. Roos, and R. de Vivie-Riedle, Molecular features in complex environment: Cooperative team players during excited state bond cleavage, Struct. Dyn. 3 (2016), 043205. W. Hua, S. Oesterling, J. D. Biggs, Y. Zhang, H. Ando, R. de Vivie-Riedle, B. P. Fingerhut, and S. Mukamel, Monitoring conical intersections in the ring opening of furan by attosecond stimulated X-ray Raman spectroscopy Struct. Dyn. 3 (2016), 023601. Other Activities Deputy speaker of the CRC 749. Pannel member of the National Centre of Compe-tence in Research MUST (Molecular Ultrafast Science and Technology).

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Physical Chemistry Prof. Dr. rer. nat. Joost Wintterlin Born 1959 in Frankfurt/Main. Studies of chemistry at the Ludwig-Maximilians-Universität, Munich. 1985 Diplom in Chemistry. 1989 PhD at the Fritz-Haber-Institut (Max Planck Society), Berlin. 1991/92 Postdoctoral fellowship at the IBM T. J. Wat-son Research Center, Yorktown Heights, NY. 1998 Habilitation at the Fritz-Haber-Institut (Max Planck Society) and at the Humboldt-Universität, Berlin. Since 2002 professor (C3) for Physical Chemistry at the Ludwig-Maximilians-Universität, Mu-nich. Research Topics Surface reactions on the atomic scale. Development of STM techniques for elevat-ed temperatures, for high pressures, and for video speed. Kinetics and dynamics of surface processes, such as adsorption of particles from the gas phase, dissociation of molecules, surface diffusion and reactions between adsorbed particles. STM of heterogeneous catalytic reactions under close-to-industrial conditions, e.g., the Ag-catalyzed synthesis of ethylene epoxide and the Co-catalyzed Fischer-Tropsch syn-thesis. Epitaxial graphene on metal surfaces. Synthesis of graphene by CVD on metal surfaces, nucleation and growth, structure, and electronic properties of epi-taxial graphene. Honors, Awards, Memberships Deutsche Physikalische Gesellschaft (DPG), American Vacuum Society (AVS), Deutsche Bunsengesellschaft, American Chemical Society (ACS). Extramural Research Funding DFG, WI 1003/7-2 01.01.2014 – 31.12.2016 Ein metallbasierter Graphensyntheseweg für elektrische Bauelemente. DFG, WI 1003/8-1 01.04.2017 – 31.03.2020 Operando-STM an Fischer-Troopsch-Modellkatalysatoren.

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Publications – Scientific Papers "Detachment of CVD-grown graphene from single crystalline Ni films by a pure gas phase reaction", P. Zeller, A.-K. Henß, M. Weinl, L. Diehl, D. Keefer, J. Lipp-mann, A. Schulz, J. Kraus, M. Schreck, J. Wintterlin, Surf. Sci. 653, 143 (2016). "Oxidation of ethylen on oxygen reconstructed silver surfaces", T. E. Jones, R. Wyrwich, S. Böcklein, T. C. R. Rocha, E. A. Carbonio, A. Knop-Gericke, R. Schlögl, S. Günther, J. Wintterlin, S. Piccinin, J. Phys. Chem. C, 120, 28630 (2016). "On the correlation of structure and catalytic performance of VPO catalysts", S. Böcklein, G. Mestl, S. V. Auras, J. Wintterlin, Top. Catal., 60, 1682 (2017). "Single crystalline metal films as substrates for graphene growth", P. Zeller, M. Weinl, F. Speck, M. Ostler, A.-K. Henß, T. Seyller, M. Schreck, J. Wintterlin, Ann. Phys. 529, 170023 (2017). Other Activities Editorial Boards: Zeitschrift für Physikalische Chemie, Surface Science.

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Pharmaceutical/Medicinal Chemistry/Biological Chemistry Univ.-Prof. Dr. rer. nat. Franz Bracher Born 1958 in Geisenfeld/Bayern, 1978-1982 studied Pharmacy at the LMU Mu-nich, 1983 approbation as pharmacist, 1986 PhD in Pharmaceutical Chemistry, LMU Munich in the group of Prof. Dr. E. Reimann. 1986-1987 Postdoc at the Département de Chimie Organique, Université de Genève (Switzerland) in the group of Prof. Dr. W. Oppolzer, 1987-1992 Hochschulassistent (Assistant Profes-sor) at the Institute for Pharmaceutical Chemistry, Philipps-University of Marburg, 1991 Habilitation for Pharmaceutical Chemistry with a thesis dealing with natural products synthesis; 1992-1997 Associate Professor (C3) at the Institute for Pharma-ceutical Chemistry at the Technical University of Braunschweig; 1996 offered a position as a Full Professor (C4) at the University of Bonn (disliked), since 1997 Full Professor for Pharmacy at the University of Munich. Research Topics Development of novel inhibitors of ergosterol biosynthesis (as antifungal agents) and cholesterol biosynthesis (including identification of new therapeutic applica-tions). Development of novel modulators of epigenetic targets (kinases, sirtuins, bromodomains, macrodomains, helicases) and of ion channels (TPC, TRPML). Natural products chemistry. Development of new screening systems. High end GC-MS analysis. Honors, Awards, Memberships Scientific Societies: Deutsche Pharmazeutische Gesellschaft (DPhG), Münchener Chemische Gesellschaft, Gesellschaft Deutscher Chemiker (GDCh), Paul Ehrlich-Gesellschaft für Chemotherapie (PEG). Member of the Editorial Advisory Boards of "Letters in Organic Chemistry", “Mini-Reviews on Organic Chemistry” and "Scientia Pharmaceutica". Publications – Scientific Papers Vögerl K, Ong DN, Bracher F. Reductive N-arylethylation of aromatic amines and N-heterocycles with enol ethers. Synthesis. 2017 [Epub dec.2017]. doi: 10.1055/ s-0036-1591859.

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Schuller M, Riedel K, Gibbs-Seymour I, Uth K, Sieg C, Gehring AP, Ahel I, Bracher F, Kessler BM, Elkins JM, Knapp S. Discovery of a selective allosteric inhibitor targeting macrodomain 2 of polyadenosine-diphosphate-ribose polymer-ase 14. ACS Chem. Biol. 2017; 12(11):2866–2874. doi: 10.1021/ acschem-bio.7b00445. Fanter L, Müller C, Schepmann D, Bracher F, Wünsch B. Chiral-pool synthesis of 1,2,4-trisubstituted 1,4-diazepanes as novel ϭ1-receptor ligands. Bioorg. Med. Chem. 2017; 25:4778-4799. doi: 10.1016/j.bmc.2017.07.027. Mailänder-Sánchez D, Braunsdorf C, Grumaz C, Müller C, Lorenz S, Stevens P, Wagener J, Hebecker B, Hube B, Bracher F, Sohn K, Schaller M. Antifungal de-fense of probiotic Lactobacillus rhamnosus GG is mediated by blocking adhesion and nutrient depletion. PLOS One. 2017; 12(10):e0184438. doi: 10.1371/ jour-nal.pone.0184438. Misslinger M, Gsaller F, Hortschansky P, Müller C, Bracher F, Bromley MJ, Haas H. The cytochrome b5 CybE is regulated by iron availability and is crucial for azole resistance in A. fumigatus. Metallomics. 2017; 9:1655-1665. doi: 10.1039/c7mt00110j. Ong DN, Dittrich S, Swyter S, Jung M, Bracher F. Synthesis of highly substituted 3-arylideneindolin-2-ones. Tetrahedron. 2017; 73:5668-5679. doi: 10.1016/ j.tet.2017.08.005. Müller C, Hemmers S, Bartl N, Plodek A, Körner A, Mirakaj V, Giera M, Bracher F. New chemotype of selective and potent inhibitors of human delta 24-dehydrocholesterol reductase. Eur. J. Med. Chem. 2017; 140:305-320. doi: 10.1016/j.ejmech.2017.08.011. Melzer BC, Bracher F. A novel approach to oxoisoaporphine alkaloids via regiose-lective metalation of alkoxy isoquinolines. Beilst. J. Org. Chem. 2017; 13:1564-1571. doi: 10.3762/bjoc.13.156. Verçoza BRF, Godinho JLP, de Macedo Silva ST, Huber K, Bracher F, de Souza W, Rodrigues JCF. KH-TFMDI, a novel sirtuin inhibitor, alters the cytoskeleton and mitochondrial metabolism promoting cell death in Leishmania amazonensis. Apoptosis. 2017; 22:1169-1188. doi: 10.1007/s10495-017-1397-8.

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Knappmann I, Lehmkuhl K, Köhler J, Schepmann D, Giera M, Bracher F, Wünsch B. Lipase-catalyzed kinetic resolution as key step in the synthesis of enantiomeri-cally pure sigma ligands with 2-benzopyran structure. Bioorg. Med. Chem. 2017; 25:3384-3395. doi: 10.1016/j.bmc.2017.04.042. Müller C, Binder U, Bracher F, Giera M. Antifungal drug testing by combining minimal inhibitory concentration testing with target identification by gas chroma-tography-mass spectrometry. Nature Protocols. 2017; 12(5):947-963. doi: 10.1038/nprot.2017.005. Nasiri HR, Hohmann K, Hatemler MG, Plodek A, Bracher F, Schwalbe H. In vitro production of reactive oxygen species (ROS) by sampangine. Med. Chem. Res. 2017; 26:1170-1175. doi: 10.1007/s00044-017-1835-8. Krauß J, Stadler M, Bracher F. Synthesis and structure-activity relationships of novel benzylamine-type antifungals as butenafine related antimycotics. Arch. Pharm. Chem. Life Sci. 2017; 350:e1600342. doi: 10.1002/ardp.201600342. Stöckelhuber M, Müller C, Vetter F, Mingo V, Lötters S, Wagner N, Bracher F. Determination of Pesticides Adsorbed on Arthropods and Gastropods by a Micro-QuEChERS Approach and GC–MS/MS. Chromatographia. 2017; 80:825-829. doi: 10.1007/s10337-017-3280-8. Vetter F, Müller C, Stöckelhuber M, Bracher F. Determination of coumarin in sea-sonal bakery products using QuEChERS and GC MS. Pharmazie. 2017; 72(6):313-316. doi: 10.1691/ph.2017.6215. Bracher F, Tremmel T. The chemistry of the canthin-4-ones. Mini-Rev. Org. Chem. 2017; 14(2):92-98. doi: 10.2174/1570193X14666161110114103. Bracher F, Tremmel T. From lead to drug utilizing a Mannich reaction: The Topo-tecan story. Arch. Pharm. Chem. Life Sci. 2017; 350:e1600236. doi: 10.1002/ardp.201600236. Popp TA, Tallant C, Rogers C, Fedorov O, Brennan PE, Müller S, Knapp S, Bracher F. Development of Selective CBP/P300 Benzoxazepine Bromo-domain Inhibitors. J. Med. Chem. 2016; 59(19):8889-8912. doi: 10.1021/acs.jmedchem.6b00774. Tremmel T, Puzik A, Gehring AP, Bracher F. Canthin-4-ones as novel antibacterial agents. Arch. Pharm. 2016; 349(9):710-723. doi: 10.1002/ardp.201600137.

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Gsaller F, Hortschansky P, Furukawa T, Carr PD, Rash B, Capilla J, Müller C, Bracher F, Bowyer P, Haas H, Brakhage AA, Bromley MJ. Sterol biosynthesis and azole tolerance is governed by the opposing actions of SrbA and the CCAAT binding complex. PLOS Pathogens 2016; 12(7):e1005775. doi: 10.1371/journal.ppat.1005775. Funke S, Matilainen J, Nalenz H, Bechtold-Peters K, Mahler HC, Vetter F, Müller C, Bracher F, Frieß W. Optimization of the bake-on siliconization of cartridges. Part II: Investigations into burn-in time and temperature. Eur. J. Pharm. Biopharm. 2016; 105, 209-222. doi: 10.1016/j.ejpb.2016.05.015. Karlas A, Berre S, Couderc T, Varjak M, Braun P, Meyer M, Gangneux N, Karo-Astover L, Weege F, Raftery M, Schönrich G, Klemm U, Wurzlbauer A, Bracher F, Merits A, Meyer T, Lecuit M. A human genome-wide loss-of-function screen identifies effective chikungunya antiviral drugs. Nat. Commun. 2016; 7:11320. doi: 10.1038/ncomms11320. Popp T, Uhl E, Ong N, Dittrich S, Bracher F. A new approach to monoprotected 1,4-benzodiazepines via a one-pot N-deprotection/reductive cyclization procedure. Tetrahedron 2016; 72(13):1668-1674. doi: 10.1016/j.tet.2016.02.019. Plodek A, Bracher F. New perspectives in the chemistry of marine pyridoacridine alkaloids. Mar. Drugs 2016; 14(2):26. doi: 10.3390/md14020026. Merk H, Zhang S, Lehr T, Müller C, Ulrich M, Bibb JA, Adams RH, Bracher F, Zahler S, Vollmar AM, Liebl J. Inhibition of endothelial Cdk5 reduces tumor growth by promoting non-productive angiogenesis. Oncotarget. 2016; 7(5):6088-6104. doi: 10.18632/oncotarget.6842. Kamlah A, Lirk F, Bracher F. A new approach to 1-substituted β-carbolines and isoquinolines utilizing tributyl[(Z)-2-ethoxyvinyl]stannane as a C-3,C-4 building block. Tetrahedron. 2016; 72:837-845. doi: 10.1016/j.tet.2015.12.049. Other Activities Editor of the "Kommentar zum Europäischen Arzneibuch" (Scientific commenta-tion of the European Pharmacopoeia). Member of the expert group for pharmaceutical chemistry of the "Deutsche Arzneibuchkommission" (German Ph. Eur. Commission). Member of the Scientific Board of "Deutscher Arzneimittel-Codex".

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Grant reviewer for Deutsche Forschungsgemeinschaft, Deutscher Akademischer Austauschdienst (DAAD) and Alexander von Humboldt Stiftung. Reviewer for Journal of Medicinal Chemistry, Bioorganic & Medicinal Chemistry, Bioorganic & Medicinal Chemistry Letters, European Journal of Organic Chemis-try, European Journal of Medicinal Chemistry, Synlett, Synthetic Communications, Tetrahedron, Tetrahedron Letters, MedChemComm, Biochemistry, Journal of Het-erocyclic Chemistry, Marine Drugs, Organic & Biomolecular Chemistry, Organic Letters, and others.

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Pharmaceutical/Medicinal Chemistry/Biological Chemistry Prof. Dr. Ivan Huc Born 1969 in Besançon, France. 1987-1991 study of chemistry in Toulouse and at the Ecole Normale Supérieure (ENS) in Paris, France. In 1994 he obtained his doc-torate from the Univ. of Paris VI for work performed at the ENS with Dr. C. Rolando, and at MIT in Cambridge, USA, with Prof. J. Rebek. From 1995 to 1998 he was at the University of Strasbourg, France, first as a Post-Doc with Dr J.-P. Behr then as a CNRS permanent researcher with Prof. J.-M. Lehn. He obtained his habilitation in 1999. In 1998, he started his independent research career as group leader at the European Institute of Chemistry and Biology at the Univ. of Bordeaux, France, where he held a CNRS research director position. In 2017, he joined the Ludwig-Maximilians-Universität (LMU) in Munich (Germany) as full Professor and head of the Chair of Chemical Biology in the Department of Pharmacy. Research Topics Molecular folding. Synthetic folded molecular architectures (foldamers) and their applications in molecular recognition of e.g. saccharides, as inhibitors of protein-protein and protein-nucleic acid interactions, and to transport electrons. Biomimetic supramolecular chemistry, chemical synthesis, structural biology. Honors, Awards, Memberships Member of the Editorial Board of Organic and Biomolecular Chemistry Member of the International Advisory Board of the Eur. Journal of Organic Chem-istry Great Prize “Mme Victor Noury” from the French Academy of Sciences Schulich Guest Professor, Technion – Israel Institute of Technology Junior Distinguished member of the French Chemical Society Extramural Research Funding European Research Council Advanced Investigator Grant (FP7), "Beyond biopol-ymers: functional aromatic amide foldamers" EU. Marie Curie Intra-European Fellowship (H2020), "Covalent-ligation-assisted elucidation of protein-aromatic foldamer interactions"

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EU. Marie Curie Initial Training Network (H2020), "Responsive molecular sys-tems" EU. Marie Curie Intra-European Fellowship (H2020), "Aryl amide metallofolda-mers as selective saccharide sensors" French national research agency (ANR) joint program with the Japan Science and Technonoly Agency (JST), "Molecular technologies for hybrid folded architec-tures" Publications – Scientific Papers Lamouroux A, Sebaoun L, Wicher B, Kauffmann B, Ferrand Y, Maurizot V, Huc I. Controlling dipole orientation through curvature: aromatic foldamer bent beta-sheets and helix–sheet–helix architectures, J. Am. Chem. Soc. 2017, 139, 14668. Wang X, Wicher B, Ferrand Y, Huc I, Orchestrating directional molecular motions: kinetically controlled supramolecular pathways of a helical host on rod like guests, J. Am. Chem. Soc. 2017, 139, 9350. Méndez-Ardoy A, Markandeya N, Li X, Tsai Y-T, Pecastaings G, Buffeteau T, Maurizot V, Muccioli L, Castet F, Huc I, Bassani DM. Multi-dimensional charge transport in supramolecular helical foldamer assemblies, Chem. Sci. 2017, 8, 8, 7251. Mateus, B. Wicher, Y. Ferrand, I. Huc*, Alkali and alkaline earth metal ion binding by a foldamer capsule: selective recognition of magnesium hydrate, Chem. Com-mun. 2017, 53, 9300 (front cover). Horeau M, Lautrette G, Wicher B, Blot V, Lebreton J, Pipelier M, Dubreuil D, Fer-rand Y, Huc I. Metal-coordination-assisted folding and guest binding in helical ar-omatic oligoamide molecular capsules, Angew. Chem. Int. Ed. 2017, 56, 6823. Hu X, Dawson SJ, Mandal PK, de Hatten X, Baptiste B, Huc I. Optimizing side chains for crystal growth from water: a case study of aromatic amide foldamers, Chem. Sci., 2017, 8, 3741. Gan Q, Wang X, Kauffmann B, Rosu F, Ferrand Y, Huc. Translation of rod-like template sequences into well-defined homochiral assemblies of stacked helical oli-gomers, Nat. Nanotech. 2017, 12, 447.

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Jewginski M, Granier T, Langlois d’Estaintot B, Fischer L, Mackereth CD, Huc I. Self-assembled protein–aromatic foldamer complexes with 2:3 and 2:2:1 stoichi-ometries. J. Am. Chem. Soc. 2017, 139, 2928. Liu Z, Hu X, Abramyan AM,. Mészáros Á, Csekei M, Kotschy A, Huc I, Pophristic V. Computational prediction and rationalization, and experimental validation of handedness induction in helical aromatic oligoamide foldamers. Chem. Eur. J. 2017, 23, 3605 (front cover). Li X, Markandeya N, Jonusauskas G, McClenaghan ND, Maurizot V, Denisov SA, Huc I, Photoinduced electron transfer and hole migration in nanosized helical aro-matic oligoamide foldamers, J. Am. Chem. Soc. 2016, 138, 13568. Lautrette G, Wicher B, Kauffmann Y, Ferrand Y, Huc I. Iterative evolution of an abiotic foldamer sequence for the recognition of guest molecules with atomic preci-sion, J. Am. Chem. Soc. 2016, 138, 10314 (front cover). Mandal PK, Baptiste B, Langlois d'Estaintot B, Kaufffmann B, Huc I. Multivalent interactions between an aromatic helical foldamer and a DNA G-quadruplex in the solid state, ChemBioChem 2016, 17, 1911. Dawson SJ, Hu X, Claerhout S, Huc I. Solid phase synthesis of helically folded ar-omatic oligoamides, Meth. Enzym. 2016, 580, 279. Mandal PK, Kauffmann B, Destecroix H, Ferrand Y, Davis AP, Huc I. Crystal structure of a complex between beta-glucopyranose and a macrocyclic receptor with dendritic multicharged water solubilizing chains, Chem. Commun. 2016, 52, 9355. Kumar PK, Collie GW, Srivastava SC, Kauffmann B, Huc I. Structure elucidation of the Pribnow box consensus promoter sequence by racemic DNA crystallog-raphy, Nucl. Acid. Res. 2016, 44, 1936. Tsiamantas C, de Hatten C, Douat C, Kauffmann B, Maurizot V, Ihara H, Takafuji M, Metzler-Nolte N, Huc I. Selective dynamic assembly of disulfide macrocyclic helical foldamers with remote handedness communication, Angew. Chem. Int. Ed. 2016, 55, 6848. Kudo M, Carbajo D, Maurizot V, Masu H, Tanatani A, Huc I. Synthesis and con-formational analysis of quinoline-oxazole peptides, Eur. J. Org. Chem. 2016, 2457.

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Nagula N, Ferrand Y, Kauffmann B, Huc I. Citric acid encapsulation by a double helical foldamer in competitive solvents, Chem. Commun. 2016, 52, 3939. Tsiamantas C, Dawson SJ, Huc I. Solid phase synthesis of oligoethylene glycol-functionalized quinolinecarboxamide foldamers with enhanced solubility proper-ties, C. R. Chimie 2016, 19, 132. Chandramouli N, Farrag El-Behairy M, Lautrette G, Ferrand Y, Huc I. Polar sol-vent effects on tartaric acid binding by aromatic oligoamide foldamer capsules, Org. Biomol. Chem. 2016, 14, 2466. Hu X, Dawson SJ, Nagaoka Y, Tanatani A, Huc. Solid-phase synthesis of water-soluble helically folded hybrid alpha-amino acid/quinoline oligoamides, J. Org. Chem. 2016, 81, 1137. Li X, Qi T, Srinivas K, Massip S, Maurizot V, Huc I. Segment doubling synthesis and multi-bromination of nanosized helical aromatic amide foldamers, Org. Lett. 2016, 18, 1044. Jewginski M, Fischer L, Colombo C, Huc I, Mackereth CD., Solution observation of dimerization and helix handedness induction in a human carbonic anhydrase-helical aromatic amide foldamer complex, ChemBioChem 2016, 17, 727. Noguchi H, Maurizot V, Takafuji M, Huc I, Ihara H. Chiral separation by a termi-nal chirality triggered P-helical quinoline oligoamide foldamer, J. Chrom. A 2016, 1437, 88. Denisov SA, Gan Q, Wang X, Scarpantonio L, Ferrand Y, Kauffmann B, Jonusauskas G, Huc I, McClenaghan ND. Electronic energy transfer modulation in a dynamic foldaxane: proof-of-principle of a lifetime-based conformation probe, Angew. Chem. Int. Ed. 2016, 55, 1328. Other Activities Co-director of the European Institute of Chemistry and Biology, Univ. Bordeaux, France. Adjunct director of the Univ. Bordeaux-CNRS Laboratory “Chemistry and Biology of membranes and nano-objects”. Co-chairman of the organization com-mittee of the “International Symposia on Foldamers” series.

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Pharmaceutical/Medicinal Chemistry/Biological Chemistry Dr. Oliver Thorn-Seshold Born 1985 in Sydney, Australia; 2007 B.Sc (Hons) in chemistry at the University of Sydney; 2009 M.Sc. in bioorganic chemistry at ENS Lyon, France; 2013 PhD in bioorganic chemistry in the group of Prof. Jens Hasserodt at ENS Lyon, France; 2013-2016 postdoctoral fellow in the group of Prof. Dirk Trauner, LMU Munich; since 2016 independent junior groupleader in pharmaceutical chemistry at LMU Munich, supported by Prof. Dr. Klaus T. Wanner. Research Topics Development of photopharmaceutical reagents for chemical biology studies, pho-toswitchable cytotoxins for cancer therapy, small molecule tumour-targeting meth-ods for nanoparticles, and sensors for biological redox processes. Tubulin inhibi-tors, topoisomerase poisons, and DNA alkylators. Honors, Awards, Memberships German Pharmaceutical Society (DPhG), Society of German Chemists (GDCh) Royal Society of Chemistry (RSC), Munich Chemical Society (MChG) Extramural Funding BMWi EXIST, “CytoSwitch: Photopharmaceuticals for Cancer Treatment” (2017-2020); BMBF GO-Bio Machbarkeit, “NanoCapture: Tumour Targeting of Nano-particles” (2017-2018); DFG SFB1032, “Nanoagents for Spatiotemporal Control” (2017-2020). Publications – Scientific Papers Zenker J, White MD, Templin RM, Parton RG, Thorn-Seshold O, Bissiere S, Plachta N. A microtubule-organizing center directing intracellular transport in the early mouse embryo. Science. 2017; 357: 925-928. doi 10.1126/science.aam9335. Eguchi K, Taoufiq Z, Thorn-Seshold O, Trauner D, Hasegawa M, Takahashi T: Wild-type monomeric α-synuclein can impair vesicle endocytosis and synaptic fi-delity via tubulin polymerization at the calyx of Held. J. Neurosci. 2017; 37: 6043-6052. doi 10.1523/jneurosci.0179-17.2017.

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Pharmaceutical/Medicinal Chemistry/Biological Chemistry Prof. Dr. rer. nat. Klaus T. Wanner Born 1954 in Schrobenhausen, Obb.; 1979 Diploma in chemistry at TU Munich; 1978-1981 studies of pharmacy at LMU München; 1983 PhD at LMU München in the group of Prof. Dr. F. Eiden; 1984 licensure as pharmacist; 1984/85 Postdoctoral fellow in the group of Prof. A. I. Meyers, Colorado State University, Fort Collins, Colorado, USA; 1988 habilitation at the Institute of Pharmacy and Food Chemistry at LMU München; 1990 Associate Professor for Pharmaceutical Chemistry FU Berlin; 1993-1994 Vice Dean of the Faculty of Pharmacy FU Berlin; since 1994 Full Professor for Pharmaceutical Chemistry at the LMU München; 1998-2000 Vice Dean and 2000-2001 Dean of the Faculty of Chemistry and Pharmacy; 1999-2000 Member of commision of budget, space and construction affaires; 2008-2010 Head of the Department of Pharmacy at LMU München. Research Topics Development of subtype selective inhibitors of GABA transporters mGAT1-mGAT4, development of MS Binding Assays and drug screening assays, develop-ment of fluorescence labelled probes and photoswitchable ligands for neurotrans-mitter transporters, computer aided drug design, new methods for the synthesis of highly functionalized nitrogen heterocycles, syntheses of amino acids, development of drugs for the regeneration of the functional activity of desensitized nicotinic ace-tylcholine receptors. Honors, Awards, Memberships German Pharmaceutical Society (DPhG) Society of German Chemists (GDCh) Extramural Funding German Federal Armed Forces, “Systematic search for compounds for the treat-ment of nicotinergic dysfunction after poisoning by nerve agents”

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Publications – scientific papers C. Scheffel, K.V. Niessen, S. Rappenglück, K.T. Wanner, H. Thiermann, F. Worek, T. Seeger, Counteracting desensitization of human α7-nicotinic acetylcholine re-ceptors with bispyridinium compounds as an approach against organophosphorus poisoning, Tox. Lett. 2017. Epub: 2017 Dec 14. doi: 10.1016/j.toxlet.2017.12.005. C Scheffel, K.V. Niessen, S. Rappenglück, K.T. Wanner, H. Thiermann, F. Worek, T. Seeger, Electrophysiological investigation of the effect of structurally different bispyridinium non-oxime compounds on human α7-nicotinic acetylcholine receptor activity - An in vitro structure-activity analysis, Tox. Lett. 2017. Epub: 2017 Nov 27. doi: 10.1016/j.toxlet.2017.11.025. S. Sichler, G. Höfner, S. Rappenglück, T. Wein, K.V. Niessen, T. Seeger, F. Worek, H. Thiermann, F.F. Paintner, K.T. Wanner, Development of MS Binding Assays targeting the binding site of MB327 at the nicotinic acetylcholine receptor, Tox. Lett. 2017. Epub: 2017 Nov 14. doi: 10.1016/j.toxlet.2017.11.013. M. Ellwart, G. Höfner, A. Gerwien, K.T. Wanner, P. Knochel, Synthesis and Bio-activity of Novel N-Benzylic and N-Phenethylic Ephedrine Derivatives, Synthesis 2017, 49, 5159-5166. doi: 10.1055/s-0036-1588523. T. Wein, G. Höfner, S. Rappenglück, S. Sichler, K.V. Niessen, T. Seeger, F. Worek, H. Thiermann, K.T. Wanner, Searching for putative binding sites of the bispyridinium compound MB327 in the nicotinic acetylcholine receptor. Tox. Lett. 2017. Epub: 2017 Oct 31. doi: 10.1016/j.toxlet.2017.10.024 K.V. Niessen, T. Seeger, S. Rappenglück, T. Wein, G. Höfner, K.T. Wanner, H. Thiermann, F. Worek, In vitro pharmacological characterization of the bispyridini-um non-oxime compound MB327 and its 2- and 3-regioisomers, Tox. Lett. 2017. Epub: 2017 Oct 10. doi: 10.1016/j.toxlet.2017.10.009. M. Schaarschmidt, K.T. Wanner, Synthesis of Allene Substituted Nipecotic Acids by Allenylation of Terminal Alkynes, J. Org. Chem. 2017, 82, 8371-8388. doi: 10.1021/acs.joc.7b00630. M. Schuller, G. Höfner, K.T. Wanner, Simultaneous Multiple MS Binding Assays addressing D1 and D2 Dopamine receptors, ChemMedChem 2017, 12, 1585-1594. doi: 10.1002/cmdc.201700369. S. Rappenglück, K.V. Niessen, T. Seeger, F. Worek, H. Thiermann, K.T. Wanner, Regioselective and Transition Metal Free Addition of tert-Butyl Magnesium Rea-

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gents to Pyridine Derivatives – A Convenient Method for the Synthesis of 3-Substituted 4-tert-Butylpyridine Derivatives, Synthesis 2017, 49, 4055-4064. doi: 10.1055/s-0036-1589025. P. Neiens, G. Höfner, K.T. Wanner, Determination of the enantiomeric purity of the selective dopamin transporter inhibitor (+)-R-R-4-(2-benzhydryloxyethyl)-1-(4-fluorbenzyl)piperidin-3-ol, Chirality 2017, 29, 294-303. doi: 10.1002/chir.22688. T. Lutz, T. Wein, G. Höfner, K.T. Wanner, Development of Highly Potent GAT1 Inhibitors: Synthesis of Nipecotic Acid Derivatives with N-Arylalkynyl Substitu-ents, ChemMedChem 2017, 12, 362-371. doi: 10.1002/cmdc.201600599. S.K. Schmidt, G. Höfner, K.T. Wanner, Determination of enantiomeric excess of nipecotic acid as 1-(7-nitrobenzo[c][1,2,5]oxadiazol-4-yl) derivatives, Chirality 2017, 29, 48-56. doi: 10.1002/chir.22670. K. Salat, A. Podkowa, N. Malikowska, F. Kern, J. Pabel, E. Wojcieszak, K. Kulig, K.T. Wanner, B. Strach, E Wyska, Novel, highly potent and in vivo active inhibitor of GABA transporter subtype 1 with anticonvulsant, anxiolytic, antidepressant and antinociceptive properties, Neuropharmacology 2017, 113 (Part A), 331-342. doi: 10.1016/j.neuropharm.2016.10.019. S. Kerscher-Hack, T. Renukappa-Gutke, G. Höfner, K.T. Wanner, Synthesis and biological evaluation of a series of N-alkylated imidazole alkanoic acids as mGAT3 selective GABA uptake inhibitors, Eur. J. Med. Chem. 2016, 124, 852-880. doi: 10.1016/j.ejmech.2016.09.012. G. Cattaneo, D. Ubiali, E. Calleri, M. Rabuffetti, G. Höfner, K.T. Wanner, M.C. De Morares, L.K.B. Martinelli, D.S. Santos, G. Speranza, G. Massolini, Development, validation and application of a 96-well enzymatic assay based on LC-ESI-MS/MS quantification for the screening of selective inhibitors against Mycobacterium tu-berculosis purine nucleoside phosphorylase, Analytica Chimica Acta 2016, 943, 89-97. doi: 10.1016/j.aca.2016.09.025. A. Sohail, K. Jayaraman, S.K. Venkatesan, K. Gotfryd, M. Daerr, U. Gether, C.J. Loland, K.T. Wanner, M. Freissmuth, W. Sandtner, T. Stockner, H. Sitte, The envi-ronmental shapes the inner vestibule of LeuT, PLoS Comput Biol. 2016, 12 (11), e1005197. doi: 10.1371/journal.pcbi.1005197. T. Hellenbrand, G. Höfner, T. Wein, K.T. Wanner, Synthesis of 4-substituted nipe-cotic acid derivatives and their evaluation as potential GABA uptake inhibitors, Bioorg. Med. Chem. 2016, 24, 2072-2096. doi: 10.1016/j.bmc.2016.03.038.

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T. Lutz, P. Spanner, K.T. Wanner, A general approach to substituted diphenyldi-azenes, Tetrahedron 2016, 72, 1579-1589. doi: 10.1016/j.tet.2016.02.011. T. Kirmeier, R. Gopalakrishnan, V. Ganal, A.M. Werner, S. Cuboni, G.C. Rudolf, G. Höfner, K.T. Wanner, S.A. Sieber, F. Holsboer, T. Rein, F. Hausch, Azidobu-pramine, a novel chemical probe to enlighten antidepressants' mode of action, PLoS ONE 2016, 11 (2), e0148608. doi: 10.1371/journal.pone.0148608. T. Wein, M. Petrera, L. Allmendinger, G. Höfner, J. Pabel, K.T. Wanner, Different Binding Modes of Small and Large Binders of GAT1, ChemMedChem 2016, 11, 509-518. doi: 10.1002/cmdc.201500534. Other Activities Member of the Organization Committee of the conference of “German Pharmaceu-tical Society”, October 4-7 2016 Grant Reviewer AvH, IUPAC, Netter-Lecture Reviewer for Angew. Chem. Int. Ed., Bioorg. Med. Chem., Bioorg. Med. Chem. Lett., Brit. J. Pharmacol., ChemMedChem, Eur. J. Med. Chem., J. Med. Chem., J. Org. Chem., Org. Biomol. Chem. Reviewer for Successful Drug Discovery Vol 3. International Advisory Board ChemMedChem

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Pharmaceutical Biology and Biotechnology Dr. rer. nat. Ulrich Lächelt Born 1983 in Saulgau, 2005-2009 study of pharmacy at the University of Heidel-berg, 2011 licensure as pharmacist, 2014 Ph.D. in Pharmaceutical Biology, 2015-2016 postdoctoral fellow and since 2017 candidate for habilitation in the group of Prof. Dr. Ernst Wagner at the LMU Munich. Research Topics Nanopharmaceuticals: nanocarriers and bioresponsive oligomers for drug delivery. Intracellular delivery of therapeutic nucleic acids, peptides and proteins. Inorgan-ic/organic hybrid nanomaterials. Topic of Habilitation: “Molecularly structured and supramolecular systems for the intracellular transport of bioactive agents” Honors, Awards, Memberships Extraordinary member of the Center for NanoScience (CeNS, LMU) Associate member of the American Society of Gene and Cell Therapy (ASGCT) Member of the German Society for Gene Therapy (DG-GT) Member of the American Chemical Society (ACS) Member of the German Pharmaceutical Society (DPhG) Extramural Research Funding Galenus Support (Galenus Privatstiftung, Wien) Excellence Cluster Nanosystems Initiative Munich (NIM), seed funding Center for NanoScience (CeNS, LMU), funding of material expenses Publications – Scientific Papers Levacic A.K., Morys S., Kempter S., Lächelt U., Wagner E., Minicircle Versus Plas-mid DNA Delivery by Receptor-Targeted Polyplexes, Hum. Gene Ther., 2017, 28(10), 862-874.

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Wang S., Li C., Qian M., Jiang H., Shi W., Chen J., Lächelt U., Wagner E., Lu W., Wang Y., Huang R., Augmented glioma-targeted theranostics using multifunctional polymer-coated carbon nanodots, Biomaterials, 2017, 141, 29-39. Zhang P., Steinborn B., Lächelt U., Zahler S., Wagner E., Lipo-Oligomer Nanoformu-lations for Targeted Intracellular Protein Delivery, Biomacromolecules, 2017, 18(8), 2509-2520. Wang S., Reinhard S., Li C., Qian M., Jiang H., Du Y., Lächelt U., Lu W., Wagner E., Huang R., Antitumoral Cascade-Targeting Ligand for IL-6 Receptor-Mediated Gene Delivery to Glioma, Mol. Ther., 2017, 25(7), 1556-1566. Heller P., Hobernik D., Lächelt U., Schinnerer M., Weber B., Schmidt M., Wagner E., Bros M., Barz M., Combining reactive triblock copolymers with functional cross-linkers: A versatile pathway to disulfide stabilized-polyplex libraries and their appli-cation as pDNA vaccines, J. Control. Release, 2017, 258, 146-160. Truebenbach I., Gorges J., Kuhn J., Kern S., Baratti E., Kazmaier U., Wagner E., Lächelt U., Sequence-Defined Oligoamide Drug Conjugates of Pretubulysin and Methotrexate for Folate Receptor Targeted Cancer Therapy, Macromol. Biosci., 2017, 17(10). Hall A., Lächelt U., Bartek J., Wagner E., Moghimi S.M., Polyplex Evolution: Under-standing Biology, Optimizing Performance, Mol. Ther., 2017, 25(7):1476-1490. Röder R., Preiß T., Hirschle P., Steinborn B., Zimpel A., Höhn M., Rädler J.O., Bein T., Wagner E., Wuttke S., Lächelt U., Multifunctional nanoparticles by coor-dinative self-assembly of His-tagged units with metal-organic frameworks, J. Am. Chem. Soc., 2017, 139(6), 2359–2368. Liu X., Zhang P., Rödl W., Maier K., Lächelt U., Wagner E., Toward Artificial Immunotoxins: Traceless Reversible Conjugation of RNase A with Receptor Tar-geting and Endosomal Escape Domains, Mol. Pharmaceutics, 2017, 14(5), 1439-1449. Morys S., Wagner E., Lächelt U., From Artificial Amino Acids to Sequence-Defined Targeted Oligoaminoamides, Methods Mol. Biol., 2016, 1445, 235-58. Lee D.J., He D., Kessel E., Padari K., Kempter S., Lächelt U., Rädler J.O., Pooga M., Wagner E., Tumoral gene silencing by receptor-targeted combinatorial siRNA polyplexes, J. Control. Release, 2016, 244(Pt B), 280-291.

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Westerhausen C., Schnitzler L.G., Wendel D., Krzysztoń R., Lächelt U., Wagner E., Rädler J.O., Wixforth A., Controllable Acoustic Mixing of Fluids in Micro-channels for the Fabrication of Therapeutic Nanoparticles, Micromachines, 2016, 7(9), 150. Beckert L., Kostka L., Kessel E., Krhac Levacic A., Kostkova H., Etrych T., Lächelt U., Wagner E., Acid-labile pHPMA modification of four-arm oligoamino-amide pDNA polyplexes balances shielding and gene transfer activity in vitro and in vivo, Eur. J. Pharm. Biopharm., 2016, 105, 85–96. He D., Müller K., Krhac Levacic A., Kos P., Lächelt U., Wagner E., Combinatorial optimization of sequence-defined oligo(ethanamino)amides for folate receptor-targeted pDNA and siRNA delivery, Bioconjug. Chem., 2016, 27(3), 647–659. Liu X., Zhang P., He D., Rödl W., Preiß T., Rädler J.O., Wagner E., Lächelt U., pH-Reversible Cationic RNase A Conjugates for Enhanced Cellular Delivery and Tumor Cell Killing, Biomacromolecules, 2016, 17, 173-182. Zimpel A., Preiß T., Röder R., Engelke H., Ingrisch M., Peller M., Rädler J.O., Wagner E., Bein T., Lächelt U., Wuttke S., Imparting Functionality to MOF Nano-particles by External Surface Selective Covalent Attachment of Polymers, Chem. Mater., 2016, 28, 3318-3326. Lee D.J., Kessel E., Edinger D., He D., Klein P.M., Voith von Voithenberg L., Lamb D.C., Lächelt U., Lehto T., Wagner E., Dual antitumoral potency of EG5 siRNA nanoplexes armed with cytotoxic bifunctional glutamyl-methotrexate target-ing ligand, Biomaterials 2016, 77, 98-110.

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Pharmaceutical Biology and Biotechnology Dr. rer. nat. Johanna Pachmayr (geb. Liebl) 2000-2005 study of pharmacy at LMU Munich, 2008 PhD degree, 2009-2010 Post-doctoral fellow and since 2011 group leader in the group of Prof. Dr. Angelika M. Vollmar, LMU Munich. Research stays at IFOM-IEO Campus, Milan, Italy, group of Prof. Dr. Giorgio Scita and at University of Uppsala, Sweden, Department of Immunology, Genetics and Pathology (IGP), Prof. Dr. Lena Claesson-Welsh. Since 05/2013 “Habilitandin” in the group of Prof. Dr. Angelika M. Vollmar, LMU Mu-nich with 10/2015 presentation “Cdk – a novel target for fighting cancer“, since 05/2017 full Professor Paracelsus Medizinische Privatuniversität PMU, Salzburg, Austria, Institute of Pharmacy Director Head of Pharmaceutical Biology and Clini-cal Pharmacy Research Topics Vascular development and tumorangiogenesis, Cancer Biology: mechanisms of cancer development and progression, cancer stem cells Cancer treatment: understanding the mechanism of small molecule compounds to treat cancer. Honors, Awards, Memberships 2016 Award for young scientists, DPhG Horst Böhme foundation Extramural Research Funding 2015 – 2017 Else Kröner-Fresenius Stiftung Publications 2016-2017 Merk H, Messer P, Ardelt M, Lamb D, Zahler S, Müller R, Vollmar A, Pachmayr J. Inhibition of the V-ATPase by Archazolid A – a new strategy to inhibit EMT Mol Cancer Ther, 2017 Aug 3

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Mandl M, Zhang S, Ulrich M, Schmoeckel E, Mayr D, Vollmar AM, Liebl J Inhibition of Cdk5 induces cell death of tumor-initiating cells Br J Cancer, 2017 Mar 28;116(7):912-922. Herzog J, Ehrlich SM, Pfitzer L, Liebl J, Fröhlich T, Arnold GJ, Mikulits W, Hai-der C, Vollmar AM, Zahler S. Cyclin-dependent kinase 5 stabilizes hypoxia-inducible factor-1α: a novel approach for inhibiting angiogenesis in hepatocellular carcinoma. Oncotarget. 2016 May 10;7(19):27108-21. Unzue A, Lafleur K, Zhao H, Zhou T, Dong J, Kolb P, Liebl J, Zahler S, Caflisch A, Nevado C. Three stories on Eph kinase inhibitors: From in silico discovery to in vivo valida-tion. Eur J Med Chem. 2016 Apr 13;112:347-66. Merk H, Zhang S, Lehr T, Bibb JA, Adams RH, Zahler S, Vollmar AM, Liebl J Inhibition of endothelial Cdk5 reduces tumor growth by promoting non-productive angiogenesis. Oncotarget. 2016 Feb 2;7(5):6088-104.

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Pharmaceutical Biology and Biotechnology Prof. Dr. rer. nat. Angelika M. Vollmar Born 1957 in Memmingen, 1978-1982 study of Pharmacy at LMU, Munich, 1984 PhD degree in Pharmaceutical Biology, LMU, 1984-1986 DFG-Postdoctoral fellow at Department of Biochemistry and Molecular Biology, University of California, Los Angeles (UCLA) USA, 1991 Habilitation at Institute of Pharmacology, Toxi-cology and Pharmacy, Veterinary School, LMU. 1991 Visiting scientist at Clinical Research Institute, Montreal, Canada, 1993 call for a Professorship “Pharmaceuti-cal Biochemistry” University of Heidelberg, 1994-1998 C3 Professorship Pharma-cology Veterinary School, 1998 C4 Professor Pharmaceutical Biology, LMU. Research Topics Potential of natural products as chemical tools and therapeutic leads in tumor research. Novel strategies and targets to meet the challenges in cancer therapy. Honors, Awards, Memberships Speaker of the DFG Research Group 1406 Member of the Scientific Advisory Board of the Catholic Academy of Bavaria Speaker of the Scientific Advisory Board of the “Robert-Bosch Stiftung – (Robert-Bosch-Hospital and Institute of Clinical Pharmacology) Member of the Scientific Advisory Board of the “Helmholtz-Zentrum für Infek-tionsforschung (HZI)” Board Member of the “Dr. Mildred Scheel Stiftung für Krebsforschung”; Member of the Executive Committee of Life Science Munich (LSM) Graduate School, Martinsried Member of the Center for Advanced Studies (CASLMU) Member of the Executive Committee of the NIM Cluster Speaker of the “Munich Center for System based Drug Research” Member of the Scientific Advisory Board of DECHEMA (“Small Molecule Natural Compounds with Biological Activity”) Member of the Scientific Advisory Board of DECHEMA (“Medicinal Biotechnol-ogy) Member of the “Stiftungsrat Dr. Robert Pfleger-Stiftung” Bamberg

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Vice Dean of the Faculty of Chemistry and Pharmacy, LMU “Fachkollegiatin” of the German Research Council (DFG), Section Medicine Member of the “Universitätsrat” of the University Ulm Member of the advisory board of the Cusanuswerk Member of the Board of Trustees of the Fraunhofer Institute for Molecular Biology and Applied Ecology Extramural Research Funding DFG-Research group 1406 – two projects Vo 376/14-2, 18-1 Excellence Cluster NIM (DFG and the Federal Ministry of Education and Re-search) DFG project: CDK5 and Hepatocellular Carcinoma (Vo 376/17-1) Bavarian Research Foundation grant (1064-13): Inhibitor of protein-protein interac-tion as novel anti-tumoral agents LMUexcellent, Förderung im Investionsfonds China Scholarship Council, PhD grant German Academic Exchange Service, PhD grant Extramural Research Funding from staff members Else Kröner-Fresenius-Stiftung, 2015-A110 (Prof. Dr. J. Liebl) Doktor Robert Pfleger-Stiftung PS89 (Dr. S. Braig) Deutsche Krebshilfe 70112107 (Dr. S. Braig) DFG Research group 1406-SCHW 178/1-1 (Dr. K. v. Schwarzenberg) Collaborative Research Center 1032 (German Research Council, DFG) „Nanoagents“ (Prof. Dr. S. Zahler) Publications – Scientific Papers Moser C, Rüdiger D, Förster F, von Blume J, Yu P, Kuster B, Kazmaier U, Vollmar AM, Zahler S. Persistent inhibition of pore-based cell migration by sub-toxic doses of miuraenamide, an actin filament stabilizer. Sci Rep. 2017 Nov 27;7(1):16407. doi: 10.1038/s41598-017-16759-7. Einer C, Hohenester S, Wimmer R, Wottke L, Artmann R, Schulz S, Gosmann C, Simmons A, Leitzinger C, Eberhagen C, Borchard S, Schmitt S, Hauck SM, von Toerne C, Jastroch M, Walheim E, Rust C, Gerbes AL, Popper B, Mayr D, Schnurr M, Vollmar AM, Denk G, Zischka H. Data on chow, liver tissue and mitochondrial

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fatty acid compositions as well as mitochondrial proteome changes after feeding mice a western diet for 6-24 weeks. Data Brief. 2017 Sep 18;15:163-169. doi: 10.1016/j.dib.2017.09.019. eCollection 2017 Dec. Einer C, Hohenester S, Wimmer R, Wottke L, Artmann R, Schulz S, Gosmann C, Simmons A, Leitzinger C, Eberhagen C, Borchard S, Schmitt S, Hauck SM, von Toerne C, Jastroch M, Walheim E, Rust C, Gerbes AL, Popper B, Mayr D, Schnurr M, Vollmar AM, Denk G, Zischka H. Mitochondrial adaptation in steatotic mice. Mitochondrion. 2017 Sep 19. pii: S1567-7249(17)30095-8. doi: 10.1016/j.mito.2017.08.015. [Epub ahead of print] Chao YK, Schludi V, Chen CC, Butz E, Nguyen ONP, Müller M, Krüger J, Kam-merbauer C, Ben-Johny M, Vollmar AM, Berking C, Biel M, Wahl-Schott CA, Grimm C. TPC2 polymorphisms associated with a hair pigmentation phenotype in humans result in gain of channel function by independent mechanisms. Proc Natl Acad Sci U S A. 2017 Oct 10;114(41):E8595-E8602. doi: 10.1073/pnas.1705739114. Epub 2017 Sep 18. Merk H, Messer P, Ardelt MA, Lamb DC, Zahler S, Müller R, Vollmar AM, Pachmayr J. Inhibition of the V-ATPase by Archazolid A: A New Strategy to In-hibit EMT. Mol Cancer Ther. 2017 Nov;16(11):2329-2339. doi: 10.1158/1535-7163.MCT-17-0129. Epub 2017 Aug 3. Mandl MM, Zhang S, Ulrich M, Schmoeckel E, Mayr D, Vollmar AM, Liebl J. In-hibition of Cdk5 induces cell death of tumor-initiating cells. Br J Cancer. 2017 Mar 28;116(7):912-922. doi: 10.1038/bjc.2017.39. Epub 2017 Feb 21. Pergola C, Schubert K, Pace S, Ziereisen J, Nikels F, Scherer O, Hüttel S, Zahler S, Vollmar AM, Weinigel C, Rummler S, Müller R, Raasch M, Mosig A, Koeberle A, Werz O. Modulation of actin dynamics as potential macrophage subtype-targeting anti-tumour strategy. Sci Rep. 2017 Jan 30;7:41434. doi: 10.1038/srep41434. Nguyen ON, Grimm C, Schneider LS, Chao YK, Atzberger C, Bartel K, Water-mann A, Ulrich M, Mayr D, Wahl-Schott C, Biel M, Vollmar AM. Two-Pore Channel Function Is Crucial for the Migration of Invasive Cancer Cells. Cancer Res. 2017 Mar 15;77(6):1427-1438. doi: 10.1158/0008-5472.CAN-16-0852. Epub 2017 Jan 20. Meier C, Steinhauer TN, Koczian F, Plitzko B, Jarolim K, Girreser U, Braig S, Marko D, Vollmar AM, Clement B. A Dual Topoisomerase Inhibitor of Intense Pro-Apoptotic and Antileukemic Nature for Cancer Treatment. ChemMedChem. 2017 Mar 7;12(5):347-352. doi: 10.1002/cmdc.201700026. Epub 2017 Feb 8.

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Bartel K, Winzi M, Ulrich M, Koeberle A, Menche D, Werz O, Müller R, Guck J, Vollmar AM, von Schwarzenberg K. V-ATPase inhibition increases cancer cell stiffness and blocks membrane related Ras signaling - a new option for HCC thera-py. Oncotarget. 2017 Feb 7;8(6):9476-9487. doi: 10.18632/oncotarget.14339. Wuttke S, Zimpel A, Bein T, Braig S, Stoiber K, Vollmar A, Müller D, Haastert-Talini K, Schaeske J, Stiesch M, Zahn G, Mohmeyer A, Behrens P, Eickelberg O, Bölükbas DA, Meiners S. Validating Metal-Organic Framework Nanoparticles for Their Nanosafety in Diverse Biomedical Applications. Adv Healthc Mater. 2017 Jan;6(2). doi: 10.1002/adhm.201600818. Epub 2016 Nov 15. Kick K, Nekolla K, Rehberg M, Vollmar AM, Zahler S. New View on Endothelial Cell Migration: Switching Modes of Migration Based on Matrix Composition. Ar-terioscler Thromb Vasc Biol. 2016 Dec;36(12):2346-2357. Epub 2016 Oct 13. Zhang S, Ulrich M, Gromnicka A, Havlíček L, Kryštof V, Jorda R, Strnad M, Vollmar AM, Zahler S. Anti-angiogenic effects of novel cyclin-dependent kinase inhibitors with a pyrazolo[4,3-d]pyrimidine scaffold. Br J Pharmacol. 2016 Sep;173(17):2645-56. doi: 10.1111/bph.13546. Epub 2016 Jul 24. Schuster SL, Segerer FJ, Gegenfurtner FA, Kick K, Schreiber C, Albert M, Vollmar AM, Rädler JO, Zahler S. Contractility as a global regulator of cellular morphology, velocity, and directionality in low-adhesive fibrillary micro-environments. Biomaterials. 2016 Sep;102:137-47. doi: 10.1016/j.biomaterials.2016.06.021. Epub 2016 Jun 14. Herzog J, Ehrlich SM, Pfitzer L, Liebl J, Fröhlich T, Arnold GJ, Mikulits W, Haider C, Vollmar AM, Zahler S. Cyclin-dependent kinase 5 stabilizes hypoxia-inducible factor-1α: a novel approach for inhibiting angiogenesis in hepatocellular carcinoma. Oncotarget. 2016 May 10;7(19):27108-21. doi: 10.18632/oncotarget.8342. Merk H, Zhang S, Lehr T, Müller C, Ulrich M, Bibb JA, Adams RH, Bracher F, Zahler S, Vollmar AM, Liebl J. Inhibition of endothelial Cdk5 reduces tumor growth by promoting non-productive angiogenesis. Oncotarget. 2016 Feb 2;7(5):6088-104. doi: 10.18632/oncotarget.6842. Foerster F, Chen T, Altmann KH, Vollmar AM. Actin-binding doliculide causes premature senescence in p53 wild type cells. Bioorg Med Chem. 2016 Jan 15;24(2):123-9. doi: 10.1016/j.bmc.2015.11.042. Epub 2015 Nov 30.

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Other Activities Mentor for “Karriereförderprogramm für Frauen aus den Begabtenförderungs-werken (KFP). Head of Academia Net Club Munich. Reviewer for various Cancer and Pharmacological/Pharmaceutical Journals i.e. Cancer Research, Mol Oncol, JBC, Am J Pathol, Blood, Oncotarget etc

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Pharmaceutical Biology and Biotechnology Prof. Dr. Ernst Wagner Born 1960 in Dachau, study of Chemistry at TU Vienna, 1983 Diploma, 1985 Ph.D. in Organic Chemistry, TU Vienna, 1994 Habilitation in Biochemistry, Uni-versity Vienna Medical Faculty, 1985-1987 Postdoctoral fellow at ETH Zurich, 1988-1995 Group leader, Institute of Molecular Pathology, Vienna, 1992-2001 Di-rector Cancer Vaccines & Gene Therapy, Boehringer Ingelheim Austria, 1995-2001 Group leader, Vienna University Biocenter, since 2001 C4-full Professor, Pharmaceutical Biotechnology, LMU, 2006-2008 Director, Department of Phar-macy, LMU, 2007-2010 Area Coordinator "Programmed Drug Delivery", since 2010 Area Coordinator “Biomedical Nanotechnologies”, Executive Board Member of “Nanosystems Initiative Munich (NIM)”, since 2016 Deputy Director, Depart-ment of Pharmacy, LMU Research Topics Biomedical Nanotechnology: Bioresponsive carriers and nanoparticle assemblies with therapeutic nucleic acids (plasmid DNA, microRNA), proteins or other bio-derived drug substances. Study of bio-interactions of such ‘Molecular Therapeu-tics’, extra- and intracellular delivery processes. Primary focus: Cancer, meeting an urgent medical need for tumor targeted delivery and breaking chemoresistance. Honors, Awards, Memberships Guest Professorship, Sichuan University, Chengdu, China (2014-17) Election as Academician of the European Academy of Sciences (2017) Election into the Controlled Release Society (CRS) College of Fellows (2017) Board of Scientific Advisors of Controlled Release Society (CRS) Member of the Austrian Chemical Society (GÖCh) Member of the German Chemical Society (GDCh) Member of American Chemical Society (ACS) Member of the American Society of Gene and Cell Therapy (ASGCT) Member of the European Society of Gene and Cell Therapy (ESGCT) Member and Board Member of the German Society for Gene Therapy (DG-GT) Member of the Center of Nanoscience (CeNS, Munich)

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Extramural Research Funding European Community IMI Research Project "COMPACT" German Research Council, Excellence Cluster Nanosystems Initiative Munich (NIM), Research Area V German Research Council, Research Unit (FOR) 1406 extension "Exploiting the Potential of Natural Compounds" German Research Council, Collaborative Research Center (SFB) 824 "Polyplexes for systemic NIS gene transfer", coinvestigator with Prof. Ch. Spitzweg German Research Council, Collaborative Research Center (SFB) 1032 "Nanoagents" German Research Council, Collaborative Research Center (SFB) 1066 "Nanodi-mensional Polymer Therapeutics for Tumor Therapy" German Research Council and Sino-German Center for Research Promotion, "Pro-grammed dual targeted lipopolymeric delivery systems for cancer gene therapy" Sino-German Center for Research Promotion, "Novel peptide-modified precise oli-gomers for cascade-targeting gene therapy of glioma" Research fellowship to a PhD student from the Bavarian Research Foundation Publications – Scientific Papers Schmohl, K.A., Dolp, P., Schug, C., Knoop, K., Klutz, K., Schwenk, N., Barten-stein, P., Nelson, P.J., Ogris, M., Wagner, E., Spitzweg, C. (2017) Reintroducing the sodium iodide symporter (NIS) to anaplastic thyroid carcinoma. Thyroid 27 (12), 1534-1543. Krhac Levacic, A., Morys, S., Wagner, E. (2017) Solid-phase Supported Design of Carriers for Therapeutic Nucleic Acid Delivery. Bioscience Reports 37 (5) BSR20160617 (20 pages). Krhac Levacic, A., Morys, S., Kempter, S., Lächelt, U., Wagner, E. (2017) Mini-circle versus plasmid DNA delivery by receptor-targeted polyplexes. Human Gene Therapy 28, 862-874. Urnauer S., Müller A. M., Schug, C., Schmohl, K.A., Tutter, M., Schwenk, N., Rödl, W., Morys, S., Ingrisch, M., Bertram, J., Bartenstein, P., Clevert, D.A., Wag-ner, E., Spitzweg, C. (2017) EGFR-targeted nonviral NIS gene transfer for bioim-aging and therapy of disseminated colon cancer metastases. Oncotarget 2017, 8, 92195-92208.

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Lee, D.J., Kessel, E., Lehto, T., Liu, X., Yoshinaga, N., Padari, K., Chen, Y.-C., Kempter, S., Uchida, S., Rädler, J.O., Pooga, M., Sheu, M.-T., Kataoka, K., Wag-ner, E. (2017) Systemic delivery of folate-PEG siRNA lipopolyplexes with en-hanced intracellular stability for gene silencing in leukemia. Bioconjugate Chem. 28, 2393-2409. Morys, S., Urnauer, S., Spitzweg, C., Wagner, E. (2017) EGFR targeting and shielding of pDNA lipopolyplexes via bivalent attachment of a sequence-defined PEG agent. Macromol Bioscience 2017, 1700203. Reinhard, S., Zhang, W., Wagner, E. (2017) Optimized solid-phase assisted synthe-sis of oleic acid-containing siRNA nanocarriers. ChemMedChem 12, 1464-1470. Zhang, P., Steinborn, B., Lächelt, U., Zahler, S., Wagner, E. (2017) Lipo-Oligomer Nanoformulations for Targeted Intracellular Protein Delivery. Biomacromolecules 18, 2509-2520. Moghimi, S.M., Wagner, E. (2017) Nanoparticle Technology: Having Impact, but Needing Further Optimization. Molecular Therapy 25, 1461-1463. Wang S, Li C, Qian M, Jiang H, Shi W, Chen J, Lächelt U, Wagner E, Lu W, Wang Y, Huang R. (2017) Augmented glioma-targeted theranostics using multi-functional polymer-coated carbon nanodots, Biomaterials 141, 29-39. Heller, P., Hobernik, D., Lächelt, U., Schinnerer, M., Weber, B., Schmidt, M., Wagner, E., Bros, M., Barz, M. (2017) Combining reactive triblock copolymers with functional cross-linkers: A versatile pathway to disulfide stabilized-polyplex libraries and their application as pDNA vaccines. J. Control. Release 258, 146-160. Krzysztoń, R., Salem, B., Lee, D.J., Schwake, G., Wagner, E., Rädler, J. O. (2017) Microfluidic Self-Assembly of Folate-Targeted Monomolecular siRNA-Lipid Na-noparticles. Nanoscale 9, 7442-7453. Urnauer, S., Klutz, K., Grünwald, G.K., Morys, S., Schwenk, N., Zach, C., Gil-dehaus, F.J., Rödl, W., Ogris, M., Wagner, E., Spitzweg, C. (2017) Systemic tu-mor-targeted sodium iodide symporter (NIS) gene therapy of hepatocellular carci-noma mediated by B6 peptide polyplexes. J. Gene Medicine 19(5). doi: 10.1002/jgm.2957.

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Morys, S., Krhac Levacic, A., Urnauer, S., Kempter, S., Kern, S., Rädler, J.O., Spitzweg, C., Lächelt, U., Wagner, E. (2017) Influence of Defined Hydrophilic Blocks within Oligoaminoamide Copolymers: Compaction versus Shielding of pDNA Nanoparticles. Polymers 9(4), 142. Wang, S., Reinhard, S., Li, C., Qian, M., Jiang, H., Du, Y., Lächelt, U., Lu, W., Wagner, E., Huang, R. (2017). Antitumoral Cascade-Targeting Ligand for IL-6 Re-ceptor-Mediated Gene Delivery to Glioma. Molecular Therapy 25, 1556-1566. Niño-Pariente, A., Armiñán, A., Reinhard, S., Scholz, C., Wagner, E., Vicent, M.J. (2017) Design of Poly-L-Glutamate-based Complexes for pDNA delivery. Macro-mol. Bioscience 2017, 17 (10) 1700029. Erratum 1700245. Schmohl, K.A., Gupta, A., Grünwald, G.K., Trajkovic-Arsic, M., Klutz, K., Braren, R., Schwaiger, M., Nelson, P.J., Ogris, M., Wagner, E., Siveke, J.T., Spitzweg, C. (2017) Imaging and targeted therapy of pancreatic ductal adenocarcinoma using the theranostic sodium iodide symporter (NIS) gene. Oncotarget 8, 33393-33404. Heissig, P., Schrimpf, W., Hadwiger, P., Wagner, E., Lamb, D.C. (2017) Monitor-ing integrity and localization of modified single-stranded RNA oligonucleotides using ultrasensitive fluorescence methods. PLOS One 12: e0173401. Zhang, P., Wagner, E. (2017) History of Polymeric Gene Delivery Systems. Top. Curr. Chem. 375: 26. Liu, X, Zhang, P, Rödl, W, Maier, K, Lächelt, U, Wagner, E. (2017) Towards arti-ficial immunotoxins: traceless reversible conjugation of RNase A with receptor tar-geting and endosomal escape domains. Mol. Pharmaceutics 14, 1439−1449. Deglmann, C.J., Blazkow-Schmalzbauer, K., Moorkamp, S., Susha, A.S., Herrler, T., Giunta, R.E., Wagner, E., Rogach, A.L., Baumeister, R.G., Ogris, M. (2017) Cadmium Telluride Quantum Dots as a Fluorescence Marker for Adipose Tissue Grafts. Ann. Plastic Surg. 78, 217-222. Röder, R., Helma, J., Preiß, T., Rädler, J.O., Leonhardt, H., Wagner, E. (2017) In-tracellular Delivery of Nanobodies for Imaging of Target Proteins in Live Cells. Pharm. Res. 34, 161–174. Reinhard, S., Wagner, E. (2017) How to Tackle the Challenge of siRNA Delivery with Sequence-Defined Oligoamino Amides. Macromol Biosci. 17(1), 1600152 (13 pages).

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Frederickson, R.M., Moghimi, S.M., Wagner, E., Yla-Herttuala, S. (2016) Call for papers: Nanoparticle development and applications in cellular and molecular thera-pies. Mol. Ther. 24, 1334-35. Klein, P. M. Reinhard, S., Lee, D.-J., Müller, K., Ponader, D., Hartmann, L., Wag-ner, E. (2016) Precise redox-sensitive cleavage sites for improved bioactivity of siRNA lipo-polyplexes. Nanoscale 8, 18098–18104. Müller, K., Klein, P.M., Heissig, P., Roidl, A., Wagner, E. (2016) EGF receptor targeted lipo-oligocation polyplexes for antitumoral siRNA and miRNA delivery, Nanotechnology 27, 464001. Westerhausen, C., Schnitzler, L.G., Wendel, D., Krzysztoń, R., Lächelt, U., Wag-ner, E., Rädler, J.O., Wixforth, A. (2016) Controllable Acoustic Mixing of Fluids in Microchannels for the Fabrication of Therapeutic Nanoparticles, Micromachines 7, 150; doi:10.3390/mi7090150. Müller, A. M., Schmohl, K.A., Knoop, K., Schug, C., Urnauer, S., Hagenhoff, A., Clevert, D.-A., Ingrisch, M., Niess, H., Carlsen, J., Zach, C., Wagner, E., Barten-stein, P., Nelson, P. J., Spitzweg, C. (2016) Hypoxia-targeted 131I therapy of hepa-tocellular cancer after systemic mesenchymal stem cell-mediated sodium iodide symporter gene delivery, Oncotarget 7, 54795-54810. Sommer, A.-K., Hermawan, A., Mickler, F.M., Ljepoja, B., Knyazev, P., Bräuchle, C., Ullrich, A., Wagner, E., Roidl, A. (2016) Salinomycin co-treatment enhances tamoxifen cytotoxicity in luminal A breast tumor cells by facilitating lysosomal degradation of receptor tyrosine kinases. Oncotarget 7, 50461-50476. Lee, D.-J., He, D., Kessel, E., Padari, K., Kempter, S., Lächelt, U., Rädler, J.O., Pooga, M., Wagner, E. (2016) Tumoral gene silencing by receptor-targeted combi-natorial siRNA polyplexes. J. Control. Release 244, 280-291. Beckert, L., Kostka, L., Kessel, E., Krhac Levacic, A., Kostkova, H., Etrych, T., Lächelt, U., Wagner, E. (2016) Acid-labile pHPMA modification of four-arm oli-goaminoamide pDNA polyplexes balances shielding and gene transfer activity in vitro and in vivo. Eur. J. Pharm. Biopharm. 105, 85–96. Müller, K., Eva Kessel, Philipp M. Klein, Miriam Höhn, Ernst Wagner (2016) Post-PEGylation of siRNA lipo-oligoamino amide polyplexes using tetra-glutamylated folic acid as ligand for receptor-targeted delivery. Molecular Pharma-ceutics 13, 2332-2345.

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Urnauer, S., Morys, S., Krhac Levacic, A., Müller, A.M., Schug, C., Schmohl, K.A., Schwenk, N., Zach, C., Carlsen, J., Bartenstein, P., Wagner, E., Spitzweg, C. (2016) Sequence defined cMET/HGFR-targeted polymers as gene delivery vehicles for the theranostic sodium iodide symporter (NIS). Molecular Therapy 24, 1395-1404. Schreiber, C., Segerer, F.J., Wagner, E., Roidl A., Rädler, J.O. (2016) Ring-Shaped Microlanes and Chemical Barriers as a Platform for Probing Single-Cell Migration. Scientific Reports 6, 26858. Jiang, Q., Yue, D., Nie, Y., Xu, X., He, Y., Zhang, S., Wagner, E., Gu, Z. (2016) Specially-Made Lipid-based Assemblies for Improving Transmembrane Gene De-livery: Comparison of Basic Amino Acid Residues-Rich Periphery. Mol. Pharma-ceutics 13, 1809-1821. Zhang, W., Müller, K., Kessel, E., Reinhard, S., He, D., Klein, P.M., Höhn, M., Rödl, W., Kempter, S., Wagner, E. (2016) Targeted siRNA Delivery Using a Lipo-Oligoaminoamide Nano-Core with an Influenza Peptide and Transferrin Shell. Adv. Healthcare Materials 5, 1493-504. Heissig, P., Klein, P.M., Hadwiger, P., Wagner, E. (2016) DNA as tunable adaptor for siRNA polyplex stabilization and functionalization. Mol. Ther. Nucleic Acids 5, e288. He, D., Müller, K., Krhac Levacic, A., Kos, P., Lächelt, U., Wagner, E. (2016) Combinatorial optimization of sequence-defined oligo(ethanamino)amides for fo-late receptor-targeted pDNA and siRNA delivery. Bioconjugate Chem. 27, 547-59. Möller, K., Müller, K., Engelke, H., Bräuchle, C., Wagner, E., Bein, T. (2016) Highly Efficient siRNA Delivery from Core-Shell Mesoporous Silica Nanoparticles with Multifunctional Polymer Caps. Nanoscale 8, 4007-4019. Hermawan, A., Wagner, E., Roidl, A. (2016) Consecutive salinomycin treatment reduces doxorubicin resistance of breast tumor cells by diminishing drug efflux pump expression and activity. Oncology Reports 35, 1732-1740.

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Other Activities Editor-in-Chief of "The Journal of Gene Medicine" Editor of “Pharmaceutical Research” Current member of the Nanoagents & Synthetic Formulations Committee, and the Physical Delivery Therapeutics & Vector Development Committee of the Ameri-can Society of Gene and Cell Therapy (ASGCT).

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Pharmaceutical Biology and Biotechnology Apl. Prof. Dr. rer. biol. Hum. Stefan Zahler Born 1964 in Rosenheim/Bayern, 1984-1989 study of biology at Ludwig-Maximilians University, Munich, 1994 PhD degree in the group of Prof. Dr. Ger-lach, Medical Faculty of the LMU, 1994-2003 Postdoctoral fellow at the Institute of Physiology, Medical Faculty, LMU (Profs. Gerlach and Pohl), 2001 teaching cre-dentials (Habilitation) in Medical Physiology, since 2003 group leader at the chair for Pharmaceutical Biology (Prof. Vollmar), 2003 teaching credential in Pharma-ceutical Biology, 2011 appointment as “außerplanmäßiger Professor” at the Faculty for Chemistry and Pharmacy, LMU. Research Topics Molecular pharmacology of natural compounds, angiogenesis (esp. tumor angio-genesis), endothelial cell biology, structured nano-surfaces and hydrogels, cell mi-gration, actin cytoskeleton, and imaging techniques. Extramural Research Funding Collaborative Research Center 1032 (DFG, German Research Council) „Nanoagents“ Publications – Scientific Papers Kick K, Nekolla K, Rehberg M, Vollmar AM, Zahler S. New View on Endothelial Cell Migration: Switching Modes of Migration Based on Matrix Composition. Ar-terioscler Thromb Vasc Biol. 2016 Dec;36(12):2346-2357. Pfeiler S, Khandagale AB, Magenau A, Nichols M, Heijnen HF, Rinninger F, Zieg-ler T, Seveau S, Schubert S, Zahler S, Verschoor A, Latz E, Massberg S, Gaus K, Engelmann B. Distinct surveillance pathway for immunopathology during acute infection via autophagy and SR-BI. Sci Rep. 2016 Oct 3;6:34440. doi: 10.1038/srep34440.

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Zhang S, Ulrich M, Gromnicka A, Havlíček L, Kryštof V, Jorda R, Strnad M, Vollmar AM, Zahler S. Anti-angiogenic effects of novel cyclin-dependent kinase inhibitors with a pyrazolo[4,3-d]pyrimidine scaffold. Br J Pharmacol. 2016 Sep;173(17):2645-56. doi: 10.1111/bph.13546. Schuster SL, Segerer FJ, Gegenfurtner FA, Kick K, Schreiber C, Albert M, Vollmar AM, Rädler JO, Zahler S. Contractility as a global regulator of cellular morphology, velocity, and directionality in low-adhesive fibrillary micro-environments. Biomaterials. 2016 Sep;102:137-47. doi: 10.1016/ j.biomaterials.2016.06.021. Nekolla K, Kick K, Sellner S, Mildner K, Zahler S, Zeuschner D, Krombach F, Re-hberg M. Influence of Surface Modifications on the Spatiotemporal Microdistribu-tion of Quantum Dots In Vivo. Small. 2016 May;12(19):2641-51. doi: 10.1002/smll.201600071. Herzog J, Ehrlich SM, Pfitzer L, Liebl J, Fröhlich T, Arnold GJ, Mikulits W, Haider C, Vollmar AM, Zahler S. Cyclin-dependent kinase 5 stabilizes hypoxia-inducible factor-1α: a novel approach for inhibiting angiogenesis in hepatocellular carcinoma. Oncotarget. 2016 May 10;7(19):27108-21. doi: 10.18632/ oncotar-get.8342. Unzue A, Lafleur K, Zhao H, Zhou T, Dong J, Kolb P, Liebl J, Zahler S, Caflisch A, Nevado C. Three stories on Eph kinase inhibitors: From in silico discovery to in vivo validation. Eur J Med Chem. 2016 Apr 13;112:347-366. doi: 10.1016/j.ejmech.2016.01.057. Segerer FJ, Röttgermann PJ, Schuster S, Piera Alberola A, Zahler S, Rädler JO. Versatile method to generate multiple types of micropatterns. Biointerphases. 2016 Mar 22;11(1):011005. doi: 10.1116/1.4940703. Merk H, Zhang S, Lehr T, Müller C, Ulrich M, Bibb JA, Adams RH, Bracher F, Zahler S, Vollmar AM, Liebl J. Inhibition of endothelial Cdk5 reduces tumor growth by promoting non-productive angiogenesis. Oncotarget. 2016 Feb 2;7(5):6088-104. doi: 10.18632/oncotarget.6842. Moser C, Rüdiger D, Förster F, von Blume J, Yu P, Kuster B, Kazmaier U, Vollmar AM, Zahler S. Persistent inhibition of pore-based cell migration by sub-toxic doses of miuraenamide, an actin filament stabilizer. Sci Rep. 2017 Nov 27;7(1):16407. doi: 10.1038/s41598-017-16759-7.

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Stoiber K, Nagło O, Pernpeintner C, Zhang S, Koeberle A, Ulrich M, Werz O, Müller R, Zahler S, Lohmüller T, Feldmann J, Braig S. Targeting de novo lipogen-esis as a novel approach in anti-cancer therapy. Br J Cancer. 2018 Jan;118(1):43-51. doi: 10.1038/bjc.2017.374 Merk H, Messer P, Ardelt MA, Lamb DC, Zahler S, Müller R, Vollmar AM, Pachmayr J. Inhibition of the V-ATPase by Archazolid A: A New Strategy to In-hibit EMT. Mol Cancer Ther. 2017 Nov;16(11):2329-2339. doi: 10.1158/1535-7163.MCT-17-0129. Zhang P, Steinborn B, Lächelt U, Zahler S, Wagner E. Lipo-Oligomer Nanoformu-lations for Targeted Intracellular Protein Delivery. Biomacromolecules. 2017 Aug 14;18(8):2509-2520. doi: 10.1021/acs.biomac.7b00666. Paulus C, Rebets Y, Tokovenko B, Nadmid S, Terekhova LP, Myronovskyi M, Zotchev SB, Rückert C, Braig S, Zahler S, Kalinowski J, Luzhetskyy A. New natu-ral products identified by combined genomics-metabolomics profiling of marine Streptomyces sp. MP131-18. Sci Rep. 2017 Feb 10;7:42382. doi: 10.1038/srep42382. Pergola C, Schubert K, Pace S, Ziereisen J, Nikels F, Scherer O, Hüttel S, Zahler S, Vollmar AM, Weinigel C, Rummler S, Müller R, Raasch M, Mosig A, Koeberle A, Werz O. Modulation of actin dynamics as potential macrophage subtype-targeting anti-tumour strategy. Sci Rep. 2017 Jan 30;7:41434. doi: 10.1038/srep41434. Fuchs S, Bischoff I, Willer EA, Bräutigam J, Bubik MF, Erdelmeier CAJ, Koch E, Faleschini MT, De Mieri M, Bauhart M, Zahler S, Hensel A, Hamburger M, Pot-terat O, Fürst R. The Dual Edema-Preventing Molecular Mechanism of the Cratae-gus Extract WS 1442 Can Be Assigned to Distinct Phytochemical Fractions. Planta Med. 2017 May;83(8):701-709. doi: 10.1055/s-0042-123388. Other Activities Head of the imaging facility of the Department of Pharmacy

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Pharmaceutical Technology and Biopharmaceutics PD Dr. habil. Julia Engert, geb. Myschik Born 1979 in Steinheim/Westf. Germany. 1999-2003 Pharmacy student at the Westfälische-Wilhelms-University Münster. November 2003 to April 2004 Post-graduate Certificate student at the School of Pharmacy, University of Otago, Dune-din, New Zealand. December 2004 License as a pharmacist in Germany. February 2005 to February 2008 PhD candidate at the School of Pharmacy, University of Otago, Dunedin, New Zealand in the group of Prof. Dr. Thomas Rades and Prof. Dr. Sarah Hook. Since August 2008 Postdoctoral research fellow in the group of Prof. Dr. Gerhard Winter, LMU Munich. Since April 2011 “Akademische Rätin auf Zeit” (tenured research staff), April 2012 to November 2016 “Habilitandin”, since December 2016 “Privatdozentin”. Research Topics Desired and undesired immunogenicity of protein therapeutics; Immunogenicity of protein aggregates; Use of recombinant spider silk in the area of drug and vaccine delivery; Epidermal powder immunization as an alternative route for vaccination; Preparation and use of lipid implants for vaccination or delivery of bioactives; In-vestigation of non-spherical particulate systems for the delivery of drugs or vac-cines. Honors, Awards, Memberships 2016 Galenus Support, Galenus Privatstiftung Editorial Board Member International Journal of Pharmaceutics Member of the Controlled Release Society (CRS) Member of the New Zealand Chapter of the Controlled Release Society (NZCRS) Publications – Scientific Papers Agostini E, Winter G, Engert J. Scale-up of water-based spider silk film casting using a film applicator. Int J Pharm. 2017 Oct 30;532(1):13-20. doi: 10.1016/j.ijpharm.2017.08.090. Epub 2017 Aug 24.

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Vollrath M, Engert J, Winter G. Long-term release and stability of pharmaceutical proteins delivered from solid lipid implants. Eur J Pharm Biopharm. 2017 Apr 22. pii: S0939-6411(16)30819-0. doi: 10.1016/j.ejpb.2017.04.017. [Epub ahead of print] Even MP, Bobbala S, Gibson B, Hook S, Winter G, Engert J. Twin-screw extruded lipid implants containing TRP2 peptide for tumour therapy, Eur J Pharm Biopharm 2017 Jan 16. pii: S0939-6411(16)30328-9. doi: 10.1016/j.ejpb.2016.12.033. [Epub ahead of print] Other Activities Reviewer for Acta Biomaterialia, AAPS PharmSciTech, Biomaterials, Comparative Medicine, Current Drug Delivery, European Journal of Pharmaceutics and Bio-pharmaceutics, Expert Review of Vaccines, International Journal of Pharmaceutics, Journal of Drug Targeting, Journal of Pharmaceutical and Biomedical Analysis, Journal of Pharmacy and Pharmacology, Molecular Pharmaceutics, Pharmaceutical Research, Polymer Bulletin, Vaccine

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Pharmaceutical Technology and Biopharmaceutics Univ.-Prof. Dr. rer. nat. Wolfgang Frieß Born 1966 in Nürnberg; 1984-1988 study of pharmacy at the FAU Erlangen-Nürnberg, 1989 licence as pharmacist; 1993 PhD degree in the group of Prof. Dr. E. Nürnberg FAU Erlangen-Nürnberg, Department of Pharmaceutical Technology; 1994-1995 Postdoctoral Fellow in the group of Prof. Dr. G. Lee FAU Erlangen-Nürnberg, Department of Pharmaceutical Technology; 1995-1996 Postdoctoral Fel-low in the group of Prof. Dr. M. Groves, Institute for Tuberculosis Research, Uni-versity of Illinois at Chicago, USA; 1996-1997 Staff Scientist, Genetics Institute, Andover, MA, USA; 1997-2001 Postdoctoral Fellow in the group of Prof. Dr. G. Lee FAU Erlangen-Nürnberg, Department of Pharmaceutical Technology; 2001 Habilitation at the FAU Erlangen-Nürnberg (Collagen as Biomaterial for Drug De-livery); since 2001 C3-Professor for Pharmaceutical Technology and Biopharma-ceutics at the Department of Pharmacy, LMU München; Cofounder of Coriolis Pharma Research Topics Formulation and Stabilization of Protein Drugs; Parenteral Depot Formulations; Freeze-Drying Honors, Awards, Memberships Member of the German Pharmaceutical Society, Member of the International Asso-ciation of Pharmaceutical Technology, Member of the Controlled Release Society, German Chapter, Editor of European Journal of Pharmaceutics and Biopharma-ceutics, Member of the Editorial Board of Pharmaceutical Technology and Devel-opment, Member of the Editorial Board of Generics and Biosimilars Initiative Journal Extramural Research Funding Industrial funding by AbbVie, Novaliq, Novartis, Sandoz, Veyx Deutsche Bundesstiftung Umwelt (DBU) Sustainable Pharmacy - Program „Depot-Zyklo“ EU Horizon 2020 MSCA-ITN-2015-ETN Pippi, Project ID: 675074 CSC Fellowship

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Publications – Scientific Papers Wang B., Friess W., Spray drying of silica microparticles for sustained release ap-plication with a new sol-gel precursor. Int. J. Pharm. 523, 2017, 281-288. Koepf E., Schroeder R., Brezesinski G., Friess W., The film tells the story: Physi-cal-chemical characteristics of IgG at the liquid-air interface. Eur. J. Pharm. Bio-pharm. 119, 2017, 396-407. Martos, A., Koch W., Jiskoot W., Wuchner K., Winter G., Friess W., Hawe A, Trends on Analytical Characterization of Polysorbates and Their Degradation Products in Biopharmaceutical Formulations. J. Pharm. Sci., 106, 2017, 1722-1735. Strüver K., Friess W., Hedtrich S., Development of a Perfusion Platform for Dy-namic Cultivation of in vitro Skin Models. Skin Pharmacol. Physiol. 30, 2017, 180-189. Korpus C., Friess W., Lyophilization Cycle Design for Dual Chamber Cartridges and a Method for Online Process Control: The "DCC LyoMate" Procedure. J. Pharm. Sci. 106, 2017, 2077-2087. Vollrath I., Pauli V., Friess W., Freitag A., Hawe A., Winter G., Evaluation of Heat Flux Measurement as a New Process Analytical Technology Monitoring Tool in Freeze Drying. J. Pharm. Sci. 106, 2017, 1249-1257. Korpus C., Friess W., Evaluation of Different Holder Devices for Freeze-Drying in Dual-Chamber Cartridges With a Focus on Energy Transfer. J. Pharm. Sci. 106, 2017, 1092-1101. Jena S., Horn J., Suryanarayanan R., Friess W., Aksan A., Effects of Excipient In-teractions on the State of the Freeze-Concentrate and Protein Stability. Pharm. Res. 34, 2017 462-478. Saller V., Matilainen J., Rothkopf C., Serafin D., Bechtold- Peters K., Mahler H.-C., Friess W., Preservative loss from silicone tubing during filling processes. Eur. J. Pharm. Biopharm. 112, 2017, 109-118. Funke S., Matilainen J., Nalenz H., Bechtold-Peters K., Mahler H.-C., Friess W., Silicone Migration From Baked-on Silicone Layers. Particle Characterization in Placebo and Protein Solutions. J. Pharm. Sci. 105, 2016, 3520-3531.

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Korpus C., Pikal M., Friess W., Heat Transfer Analysis of an Optimized, Flexible Holder System for Freeze-Drying in Dual Chamber Cartridges Using Different State-of-the-Art PAT Tools. J. Pharm. Sci. 105, 2016, 3304-3313. Funke S., Matilainen J., Nalenz H., Bechtold-Peters K., Mahler H.-C., Vetter F., Mueller C., Bracher F., Friess W., Optimization of the bake-on siliconization of cartridges. Part II: Investigations into burn-in time and temperature. Eur. J. Pharm. Biopharm. 105, 2016, 209-222. Funke S., Matilainen J., Nalenz H., Bechtold-Peters K., Mahler H.-C., Friess W., Optimization of the bake-on siliconization of cartridges. Part I: Optimization of the spray-on parameters. Eur. J. Pharm. Biopharm. 104, 2016, 200-215. Other Activities Co-Organizer of Conference on Freeze-Drying of Pharmaceuticals and Biologicals, Breckenridge, CO, 2016; Co-Organizer of DPhG Jahrestagung 2016 Muenchen, Grant reviewer for DFG and BMBF; Reviewer for EJPB, Pharm Res, J Pharm Sci, J Contr Rel, J Pharm Pharmacol, EJPS

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Pharmaceutical Technology and Biopharmaceutics Univ.-Prof. Dr. rer. nat. Olivia M. Merkel Pharmacy studies at Philipps-Universität Marburg, Approbation 2005, M.S. in Pharm. Technology at Martin-Luther-Universität Halle Wittenberg 2006, Ph.D. in Pharm. Technology in Marburg 2006-2009, 2009-2011 Postdoc in Pharm. Tech-nology in Marburg, 2011-2017 Assistant Professor of Pharmaceutical Sciences at Wayne State University, Detroit, MI, USA, 2012-2017 Associate Faculty of Oncol-ogy at Wayne State University and Scientific Member of the Barbara Ann Karmanos Cancer Institute in Detroit, MI, USA. 2015-2016 Interim W2 Professor for Drug Delivery LMU Munich. Since 2016 Professor for Drug Delivery at the Department Pharmacy – Center for Drug Research at the LMU München. Research Topics Synthetic nano-sized delivery systems for siRNA and CRISPR/Cas, Polymeric ma-terials, Novel safe and target-specific nanomedicines, Smart dosage forms, Spray drying, Hydrogels, Local administration routes, T cell and macrophage targeting, Molecular treatments for lung diseases, inflammatory and cancerous diseases. Honors, Awards, Memberships Galnus Technologie Preis 2015 ERC Starting Grant 2014 Dr. Jack Ryan Award endowed by the Dr. Morris S. Brent Fund 2014 Phoenix Pharma Preis 2012 Lindau Nobel Participant 2012 Young Pharmaceutical Investigator Award (EUFEPS) 2011 Carl-Wilhelm-Scheele-Award (DPhG, best PhD thesis) 2010 Wissenschaftspreis der Industrie- und Handelskammer Kassel (best PhD thesis) 2010 ISAM Research Award 2009 Nachwuchsförderung der Deutschen Lungenstiftung 2009 Member of: Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik (APV) Controlled Release Society (CRS) Deutsche Pharmazeutische Gesellschaft (DPhG)

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Extramural Research Funding Public funding: ERC, Else-Kröner-Fresenius-Stiftung, Deutsche Gesellschaft für Muskelkranke, Fondazione Fibrosi Cistica, Industrial research partners: BI, AbbVie, Sanofi, Apurano Total funding in the review period: > 900.000€ Publications – Scientific Papers Steven K Jones, Anwesha Sarkar, Daniel P Feldmann, Peter Hoffmann, Olivia M Merkel*: Revisiting the value of competition assays in folate receptor-mediated drug delivery. Biomaterials 2017, 138, 35-34. Daniel P Feldmann, Yuran Xie, Steven K Jones, Dongyue Yu, Anna Moszczynska, Olivia M Merkel*: The impact of microfluidic mixing of triblock micelleplexes on in vitro/in vivo gene silencing and intracellular trafficking. Nanotechnology 2017, 28(22), 224001. Rima Kandil, Jon Felt, Prashant Mahajan, Olivia M. Merkel*: The Biology and Clinical Treatment of Asthma, Nanomedicine for Inflammatory Diseases, 2017, CRC Press, pp.217-244. Yuran Xie, Rima Kandil, Olivia M. Merkel*: Bridging the Gap between the Bench and the Clinic: Asthma, Nanomedicine for Inflammatory Diseases, 2017, CRC Press, pp.255-286. Yuran Xie, Bryan Killinger, Anna Moszczynska, Olivia M Merkel*: Targeted De-livery of siRNA to Transferrin Receptor Overexpressing Tumor Cells via Peptide Modified Polyethylenimine. Molecules, 2016, 21 (10), E1334 Mariam Mohammadi, Ying Li, Daniel G Abebe, Yuran Xie, Rima Kandil, Teresa Kraus, Nardhy Gomez-Lopez, Tomoko Fujiwara, Olivia M Merkel*: Folate recep-tor targeted three-layered micelles and hydrogels for gene delivery to activated macrophages. Journal of Controlled Release, 2016doi:10.1016/j.conrel.2016.08.020 Sara Movassaghian, Yuran Xie, Claudia Hildebrandt, Rayna Rosati, Ying Li, Na Hyung Kim, Denise S Conti, Sandro RP da Rocha, Zeng-Quan Yang, Olivia M Merkel*: Post-transcriptional regulation of the GASC1 oncogene with active tu-mor-targeted siRNA-nanoparticles.Molecular Pharmaceutics, 2016, 13 (8), 2605-21

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Qian Zhong, Olivia M Merkel, Joshua J Reineke, Sandro RP da Rocha: Effect of the Route of Administration and PEGylation of Poly(amidoamine) Dendrimers on Their Systemic and Lung Cellular Biodistribution. Molecular Pharmaceutics, 2016, 3 (6), 1886-78 Yuran Xie, Na Hyung Kim, Venkatareddy Nadithe, Dana Schalk, Archana Thakur, Ayşe Kılıç, Lawrence G Lum, David JP Bassett, Olivia M Merkel*: Targeted de-livery of siRNA to activated T cells via transferrin-polyethyleneimine (Tf-PEI) as a potential therapy of asthma. Journal of Controlled Release, 2016, 229, 120-9 Steven K Jones, Vincent Lizzio, Olivia M Merkel*: Folate Receptor Targeted De-livery of siRNA and Paclitaxel to Ovarian Cancer Cells via Folate Conjugated Triblock Copolymer to Overcome TLR4 Driven Chemotherapy Resistance. Biomacromolecules, 2016, 17 (1), 76-87 Li Liu, Mengyao Zheng, Damiano Librizzi, Thomas Renette, Olivia M Merkel*, Thomas Kissel: Efficient and Tumor Targeted siRNA Delivery by Polyethyl-enimine-graft-polycaprolactone-block-poly(ethylene glycol)-folate (PEI-PCL-PEG-Fol). Molecular Pharmaceutics, 2016, 13 (1), 134-43 Daniel G. Abebe, Rima Kandil, Teresa Kraus, Maha Elsayed, Tomoko Fujiwara, Olivia M. Merkel*: Stealth polyplexes: biodegradable three-layered micelles and injectable hydrogels, Methods Mol Biol. 2016, 1445, 175-85. Steven K Jones, Olivia M. Merkel: Indium-labeling of siRNA for small animal SPECT imaging, Methods Mol Biol. 2016, 1372, 79-88. Steven Jones, Olivia M. Merkel*: Tackling Breast Cancer Chemoresistance with Nano-Formulated siRNA, Nature Gene Therapy, 2016, doi:10.1038/gt.2016.67 Rima Kandil, Olivia M. Merkel*: Therapeutic Delivery of siRNA: Diseases affect-ing the respiratory system, Die Pharmazie, 2016, 71 (1), 21-26. Other Activities Member of the editorial Boards of EJPB and J Controlled Rel Reviewer for many journals, consultant to Pharma industry Co-organizer for Galenus Symposium Munich, Munich 2018

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Pharmaceutical Technology and Biopharmaceutics Univ.-Prof. Dr. rer. nat. Gerhard Winter Pharmacy studies (Scholarship Studienstiftung des Deutschen Volkes) at the Uni-versity of Heidelberg, Approbation (state licence) 1982. Ph.D. in Pharm. Technol-ogy in Heidelberg 1983-1987, 1987-88 Laboratory Head at E. Merck, Darmstadt, 1988 - 1999 Laboratory Head, Group leader, Director for Pharmaceutical Devel-opment at Boehringer Mannheim GmbH, later Roche Diagnostics GmbH, Mann-heim. Responsible i.a. for market products NeoRecormon, Reteplase, Bonviva. Since 1999 Professor for Pharmaceutical Technology and Biopharmaceutics at the Department Pharmacy – Center for Drug Research at the LMU München, Research Stay at the University of Colorado, Denver 2004 und 2007. Co-Founder of LMU spin-off Coriolis Pharma, Martinsried in 2008. Supervisor for 60 Ph.D. theses until end of 2017. Research Topics Formulation and delivery of peptide and protein drugs, including parenteral depot systems and drug-device combinations. Colloidal drug carriers, especially thermo-sensitive Liposomes, nanoparticles for immunotherapy, non spherical nanoparti-cles. Parenteral process technologies, freeze drying and alternative drying technol-ogies. Lipid based depot systems, protein–lipid interactions. New excipients and biomaterials in protein formulation. New vaccination technologies including device and adjuvant aspects. Immunogenicity of protein aggregates. HT stability predic-tion methods for protein formulations. Application of molecular modelling in pro-tein galenics. Nasal protein formulations. Honors, Awards, Memberships Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik (APV) Controlled Release Society (CRS) Deutsche Pharmazeutische Gesellschaft (DPhG) Bayern Conference President DPhG Annual Meeting 2016, München Wiss. Beirat der DPhG Wiss. Beirat des PID, Brauschweig Wiss. Beirat des DDIC, Leverkusen Head Award Committee APV-Award Head Examination Committee for „Fachapotheker Pharm. Technol.“ in Bavaria

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Beirat der Fachhochschule Biberach Org. committee member for International Conference on Freeze Drying 2006, 2008, 2010, 2012, 2014, 2016 Extramural Research Funding Public funding: CSC, BFS, BMBF, EU (ITN), DAAD, DZIF Industrial research partners: Bayer, Roche, BI, Probiogen, BioskinCo Total funding in the review period: ca. 600.000€, plus 4 scholarships for PhD stu-dents Publications – Scientific Papers G.Balsevich, A.S. Häusl, C.W. Meyer, S. Karamihalev, X. Feng, M.L. Pöhlmann, C. Dournes, A. Uribe-Marino, S. Santarelli, C. Labermaier, K. Hafner, T. Mao, M. Breitsamer, M. Theodoropoulou, C. Namendorf, M. Uhr, M. Paez-Pereda, G. Win-ter, F. Hausch, A. Chen, M.H. Tschöp, T. Rein, N.C. Gassen, M.V. Schmidt Stress-responsive FKBP51 regulates AKT2-AS160 signaling and metabolic func-tion, Nature Communications 2017 Nov 23:, 8(1):1725, DOI: 10.1038/s41467-017-01783-y. PMID: 29170369 J. Klier, S. Geis, J. Steuer, K. Geh, S. Reese, S. Fuchs, R.S. Mueller, G. Winter, H. Gehlen A comparison of nanoparticullate CpG immunotherapy with and without allergens in spontaneously equine asthma-affected horses, an animal model Immun Inflamm Dis. 2017 Nov 1. DOI: 10.1002/iid3.198. PMID: 29094511 B. Werner, G. Winter, Addressing Protein Aggregation, The Medicine Maker 2017 Nov; 38-40 E. Agostini, G. Winter, J. Engert Scale-up of water-based spider silk film casting using a film applicator Int J Pharm. 2017 Oct 30; 532(1): 13-20. Epub 2017 Aug 24. PMID: 28844898 M. Schargus, B.P. Werner, G. Geerling, G. Winter CONTAMINATION OF ANTI-VEGF DRUGS FOR INTRAVITREAL INJECTION: How Do Repackaging and Newly Developed Syringes Affect the Amount of Silicone Oil Droplets and Protein Aggregates Retina. 2017 Aug 21. doi: 10.1097/IAE.000000000000809. PMID: 28841584

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J.J. Mittag, B. Kneidl, T. Preiß, M. Hossann, G. Winter, S. Wuttke, H. Engelke, J.O. Rädler Impact of plasma protein binding on cargo release by thermosensitive liposomes probed by fluorescence correlation spectroscopy Eur J Pharm Biopharm. 2017 Oct; 119: 215-223. Epub 2017 Jun 23. PMID: 28648864 R. Wanner, D. Breitsprecher, S. Duhr, P. Baaske, G. Winter Thermo-Optical Protein Characterization for Straightforward Preformulation De-velopment, J Pharm Sci. 2017 Oct; 106(10): 2955-2958. Epub 2017 Jun 15. PMID: 2824419 I. Wagner, K. Geh, M. Hubert, G. Winter, K. Weber, J. Classen, C. Klinger, R.S. Mueller, Preliminary evaluation of cytosine-phosphate-guanine oligodeoxynucleo-tides bound to gelatine nanoparticles as immunotherapy for canine atopic dermatitis Vet Rec. 2017 Jul 29; 181(5):118. doi: 10.1136/vr.104230. Epub 2017 May 19 M. Vollrath, J. Engert, G. Winter Long-term release and stability of pharmaceutical proteins delivered from solid li-pid implants, Eur J Pharm Biopharm. 2017 Aug; 117:244-255. Epub 2017 Apr 22. PMID 28442372 S.M. Patel, S.L. Nail, M.J. Pikal, R. Geidobler, G. Winter, A. Hawe, J. Davagnino, S. Rambhatla Gupta, Lyophilized Drug Product Cake Appearance: What is Ac-ceptable? J Pharm Sci. 2017 Jul; 106(7): 1706-1721. Epub 2017 Mar 22. PMID: 28341598 A. Martos, W. Koch, W. Jiskoot, K. Wuchner, G. Winter, W. Friess, A. Hawe Trends on Analytical Characterization of Polysorbates and Their Degradation Products in Biopharmaceutical Formulations, J Pharm Sci. 2017 Jul; 106(7): 1722-1735. Epub 2017 Mar 14. Review. PMID: 28302541 M. Utzinger, A. Jarzebinska, N. Haag, M. Schweizer, G. Winter, C. Dohmen, C. Rudolph, C. Plank, cmRNA/lipoplex encapsulation in PLGA microsheres enables transfection via calcium phosphate cement (CPC)/PLGA composites, J Control Re-lease. 2017 Mar 10; 249:143-149. Epub 2017 Feb 2. PMID:28161466 M.P. Even, S. Bobbala, B. Gibson, S. Hook, G. Winter, J. Engert Twin-screw extruded lipid implants containing TRP2 peptide for tumour therapy Eur J Pharm Biopharm. 2017 May; 114:79-87. Epub 2017 Jan 16. PMID: 28104440

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I. Vollrath, V. Pauli, W. Friess, A. Freitag, A. Hawe, G. Winter, Evaluation of Heat Flux Measurement as a New Process Analytical Technology Monitoring Tool in Freeze Drying, J Pharm Sci. 2017 May; 106(5):1249-1257. Epub 2017 Jan 4. PMID: 28063826 M. Breitsamer, G. Winter, Needle-Free Injection of Vesicular Phospholipid Gels-A Novel Approach to Overcome an Administration Hurdle for Semisolid Depot Sys-tems, J Pharm Sci. 2017 Apr; 106(4): 968-972. Epub 2016 Dec 29. PMID: 28041969 M.L. Poehlmann, J. Hartmann, D. Harbich, B. Schmid, A.S. Häusl, N. Dedic, X. Feng, F. Hausch, M. Breitsamer, G. Winter, J. Deussing, M.V. Schmidt, Unravel-ing the functional contribution of FKBP-51 in monoaminergic brain areas to stress vulnerability in mice, Eur Neuropsychopharmacol. 2017 Mar; 27(1):39. doi: 10.1016/S0924-977X(17)30109-8 L. Rodrigues, K. Kyriakos, F. Schneider, H. Dietz, G. Winter, C.M. Papadakis, M. Hubert, Characterization of Lipid-Based Hexosomes as Versatile Vaccine Carriers Mol Pharm. 2016 Nov 7; 13(11):3945-3954. Epub 2016 Sep 27. PMID:27607892 K.J. Geh, M. Hubert, G. Winter, Optimisation of one-step desolvation and scale-up of gelatine nanoparticle production, J Microencapsul. 2016 Nov; 33(7):595-604. Epub 2016 Sep 7. PMID: 27556342 J. Klier, C. Zimmermann, L.S. Goehring, G. Winter, H. Gehlen, Nanoparticulate CpG immunotherapy in RAO-affected horses: dose effect, long term benefits and comparison with beclomethasone inhalation, Equine Vet J 2016 Sep 1; doi: 10.1111/evj.03_1261 C. Hildebrandt, R. Mathaes, R. Saedler, G. Winter, Origin of Aggregate Formation in Antibody Crystal Suspensions Containing PEG, J PharmSci. 2016 Mar; 105(3):1059-65.. Epub 2016 Feb 2. PMID: 26886344 Other Activities Member of the editorial Boards of EJPB and J Pharm Sci. Reviewer for many journals Consultant to Pharma and Biotec industry, member of Scientific Advisory boards Local Head of German Pharm. Society, organization of 9 public lectures/ year Co-founder of biopharmaceutical interest group with Copenhagen and Leiden Department Head Pharmacy 2015 and 2016

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Pharmacology Prof. Dr. rer. nat. Martin Biel Born 1963 in Völklingen/Saar. 1983-1988 Study of Pharmacy at the Saarland Uni-versity. 1988-1990 Graduate research at the Institute of Physiological Chemistry, Saarland University. 1990 PhD degree. 1991-1996 Postdoctoral Fellow at the De-partment of Pharmacology and Toxicology, TU Munich. 1996 Venia legendi in Pharmacology and Toxicology at the Medical Faculty of TU Munich. 1996-1999 “Privatdozent” (equivalent to assistant professorship) at the Institute of Pharmacol-ogy and Toxicology, TU Munich. 1997 Offer for a Professorship for Pharmacology at the FU Berlin. Since 1999 C4 Professor and Chair of Pharmacology at the Facul-ty of Chemistry and Pharmacy, LMU. 2007-2009 Vice Dean and 2009-2011 Dean of the Faculty of Chemistry and Pharmacy, LMU. Research Topics Role of ion channels in physiology and disease. Pacemaker channels. Molecular basis of cardiac rhythmicity. Endolysosomal ion channels. Control of neuronal cir-cuit function by ion channels. Visual transduction and analysis of retinal diseases. Development of gene therapy approaches to restore vision. Development of genetic mouse models as disease models. Honors, Awards, Memberships Feldberg Prize Member of the Bavarian Academy of Sciences Member of the German Academy of Sciences Leopoldina Member of the Munich Heart Alliance Member of the Munich Center for Neurosciences (MCN) Member of the Editorial Board Frontiers in Pharmacology of Ion Channel and Channelopathies Member of the Editorial Board Medizinische Monatsschrift für Pharmazeuten Member of the German Pharmaceutical Society (DPhG) Member of the German Society for Experimental and Clinical Pharmacology and Toxicology (DGPT) Member of the German Ophthalmological Society (DOG)

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Extramural Research Funding Excellence Cluster Center for Integrated Protein Sciences Munich (DFG and the Federal Ministry of Education and Research) Graduate School Systemic Neurosciences (DFG and the Federal Ministry of Educa-tion and Research) Collaborative Research Center 870 (German Research Council) Transregional Collaborative Research Center 152 (German Research Council) RD Cure: Bringing Gene Supplementation Therapy for Inherited PDE6A- and CNGA3-associated Retinopathies into Clinical Practice (Kerstan Foundation) Publications – Scientific Papers Fenske S, Pröbstle R, Auer F, Hassan S, Marks V, Pauza D, Biel M, Wahl-Schott C (2016) Comprehensive multi-level in vivo and in vitro Analysis of Heart Rate Fluc-tuations in mice by ECG telemetry and electrophysiology. Nature Protocols 11: 61-86 Laprell L, Hüll K, Stawski P, Schoen C, Michalakis S, Biel M, Sumser M, Trauner D. (2016) Restoring light sensitivity in blind retinae using a photochromic AMPA receptor agonist. ACS Chemical Neuroscience 7:15-20. doi: 10.1021/acschemneuro.5b00234. Auffenberg E, Jurik A, Mattusch C, Stoffel R, Genewsky A, Namendorf C, Schmid RM, Rammes G, Biel M, Uhr M, Moosmang S, Michalakis S, Wotjak CT, Thoeringer CK (2016). Remote and reversible inhibition of neurons and circuits by small molecule induced potassium channel stabilization. Sci Rep 6:19293. Doi: 10.1038/srep19293. Becirovic E, Böhm S, Nguyen O, Riedmayr LM, Koch MA, Schulze E, Kohl S, Borsch O, Santos-Ferreira T, Ader M, Michalakis S, Biel M (2016) In vivo analysis of disease-associated point mutations unveils profound differences in mRNA splic-ing of peripherin.2 in rod and cone photoreceptors. PLoS Genetic 12:e1005811. doi: 10.1371/journal.pgen.1005811. Schön C, Asteriti S, Koch S, Sothilingam V, Garcia Garrido M, Tanimoto N, Herms J, Seeliger MW, Cangiano L, Biel M, Michalakis S. Loss of HCN1 enhanc-es disease progression in CNG channel-linked retinitis pigmentosa and achroma-topsia (2016) Hum Mol Genet 25:1165-1175. doi: 10.1093/hmg/ddv639.

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Sothilingam V, Michalakis S, Garrido MG, Biel M, Tanimoto N, Seeliger MW (2016) HCN1 channels enhance rod system responsivity in the retina under condi-tions of light exposure. PLoS one 11:e0147728. doi: 10.1371/journal.pone.0147728. Nguyen ONP, Böhm S, Gießl A, Butz ES, Wolfrum U, Brandtstätter JH, Wahl-Schott C, Biel M, Becirovic E (2016) Peripherin-2 differentially interacts with cone opsins in outer segments of cone photoreceptors. Hum Mol Genet 25:2367-2377. Kostic C, Crippa SV, Martin C, Kardon RH, Biel M, Arsenijevic Y, Kawasaki A (2016) Determination of rod and cone influence to the early and late dynamic of the pupillary light response. Invest Ophthalmol Vis Sci 57: 2501-2508. Becirovic E, Boehm S, Nguyen ONP, Riedmayr LM, Hammelmann V, Schön C, Butz ES, Wahl-Schott C, Biel M, Michalakis S (2016) AAV vectors for FRET-based analysis of protein-protein interactions in photoreceptor outer segments. Front. Neurosci. doi: 10.3389/fnins.2016.00356. Butz ES, Ben-Johny M, Shen M, Yang PS, Sang L, Biel M, Yue DT, Wahl-Schott C (2016) Quantifying Macromolecular Interactions in Living cells using FRET 2-hybrid Assays. Nature Protocols 11:2470-2498. Decembrini S, Martin C, Sennlaub F, Chemtaub S, Biel M, Samardzija M, Moulin A, Roska B, Behar-Cohen F, Arsenijevic Y (2016) The cone genesis tracing by the Chrnb4-EGFP-mouse line allows the identification of transplantation-competent cone precursors. Mol Ther 25:634-653. Nguyen ONP, Grimm C, Schneider LS, Chao YK, Bartel K, Atzberger C, Water-mann A, Ulrich M, Mayr D, Wahl-Schott C, Biel M, Vollmar AM (2017) Two-pore channel function is crucial for migration of invasive cancer cells. Cancer Res. 77:1427-1438. Bobak N, Feliciangeli S, Chen CC, Soussia IB, Bittner S, Biel M, Wahl-Schott C, Grimm C, Meuth SG, Lesage F. (2017) Tandem of pore-domains in a Weakly In-ward rectifying K+ channel 2 (TWIK2) is a lysosomal channel. Sci Rep 7(1):649. doi: 10.1038/s41598-017-00640-8. Chen CC, Cang C, Fenske S, Butz E, Chao YK, Biel M, Ren D, Wahl-Schott C, Grimm C (2017) Patch clamp technique to characterize ion channels in individual intact endolysosomes. Nature Protocol. 12:1639-1658.

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Böhm S, Riedmayr LM, Nguyen ONP, Gießl A, Liebscher T, Butz ES, Schön C, Michalakis S, Wahl-Schott C, Biel M, Becirovic E (2017) Peripherin-2 and Rom-1 have opposing effects on rod outer segment targeting of retinitis pigmentosa-linked peripherin-2 mutants. Sci Rep 7:2321. doi: 10.1038/s41598-017-02514-5 Laprell L, Tochitsky I, Kaur K, Manookin MB, Stein M, Barber DM, Schoen C, Michalakis S, Biel M, Kramer RH, Sumser MP, Trauner D, and van Gelder RN (2017). Photopharmacological control of bipolar cells enables the restoration of visual function. J Clin Invest 127:2598-2611. Mühlfriedel R, Tanimoto N, Schön C, Sothilingam V, Garrido MG, Beck SC, Hu-ber G, Biel M, Seeliger MW, Michalakis S (2017). AAV-mediated gene supple-mentation therapy in achromatopsia type 2: preclinical data on therapeutic time window and long-term effects. Frontiers in Neuroscience doi: 10.3389/fnins.2017.00292. Butler MR, Ma H, Yang F, Belcher J, Le YZ, Mikoshiba K, Biel M, Michalakis S, Iuso A, Krizaj D, and Ding XQ (2017) Endoplasmic reticulum Ca2+ channel activi-ty contributes to endoplasmic reticulum stress and cone death in cyclic nucleotide-gated channel deficiency. J Biol Chem 292:11189-11205. Chen CC, Butz ES, ChaoYK, Grishchuk Y, Becker L, Heller S, Slaugenhaupt SA, Biel M, Wahl-Schott C, Grimm C (2017). Small molecules for organelle-specific patch-clamp. Cell Chemical Biology 24:907-916. Herrmann S, Rajab H, Christ I, Schirdewahn C, Höfler D, Fischer JM, Bruno A, Fenske S, Gruner C, Kramer F, Wachmann T, Wahl-Schott C, Stieber J, Biel M, Ludwig A. Protein kinase A regulates inflammatory pain sensitization by modula-ting HCN2 channel activity in nociceptive sensory neurons. (2017) Pain 158:2012-2024. Chao YK, Schludi V, Chen CC, Butz E, Nguyen ONP, Müller M, Krüger J, Kam-merbauer C, Vollmar AM, Berking C, Biel M, Wahl-Schott C, Grimm C (2017). TPC2 polymorphisms associated with a hair pigmentation phenotype in humans result in gain of channel function by independent mechanisms. Proc Natl Acad Sci USA 114:E8595-E8602. Castonguay J, Orth JHC, Müller T, Sleman F, Grimm C, Wahl-Schott C, Biel M, Mallmann RT, Bild W, Schulte U, Klugbauer N (2017). The two-pore channel TPC1 is required for efficient protein processing through early and recycling en-dosomes. Sci Rep 7:10038. doi: 10.1038/s41598-017-10607-4.

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Ochakovski GA, Peters T, Michalakis S, Wilhelm B, Wissinger B, Biel M, Bartz-Schmidt KU, Fischer MD and the RD-CURE Consortium (2017). Subretinal Injec-tion for Gene Therapy Does Not Cause Clinically Significant Outer Nuclear Layer Thinning in Normal Primate Foveae. Invest Ophthalmol Vis Sci. 58:4155-4160. Reichel FF, Dauletbekov DL, Klein R, Peters T, Ochatkovski GA, Seitz IP, Wil-helm B, Ueffing M, Biel M, Wissinger B, Michalakis S, Bartz-Schmidt KU, Fis-cher MD and the RD-CURE Consortium (2017) AAV8 can induce innate and adap-tive immune response in the primate eye. Mol Ther 25:2648-2660. Seitz IP, Michalakis S, Wilhelm B, Reichel FF, Ochakovski GA, Zrenner E, Uef-fing M, Biel M, Wissinger B, Bartz-Schmidt KU, Peters T, Fischer MD and the RD-CURE Consortium (2017). Superior retinal gene transfer and biodistribution profile of subretinal vs. intravitreal delivery of AAV8 in non-human primates In-vest Ophthalmol Vis Sci 58:5792-5801. Schön C, Sothilingam V, Mühlfriedel R, Garrido MG, Beck SC, Tanimoto N, Wis-singer B, Paquet-Durand F, Biel M, Michalakis S, Seeliger MW and the RD-CURE Consortium (2017) Gene therapy successfully delays degeneration in a mouse mo-del of PDE6A-linked retinitis pigmentosa (RP43). Hum Gene Ther. 2017 Dec 7. doi: 10.1089/hum.2017.156. [Epub ahead of print]. Occelli LM, Schön C, Seeliger MS, Biel M, Michalakis S, Peterson-Jones and the RD-CURE Consortium (2017) Gene Supplementation Rescues Rod Function and Preserves Photoreceptor and Retinal Morphology in Dogs, Leading the Way To-wards Treating Human PDE6A-Retinitis Pigmentosa. Hum Gene Ther. 2017 Dec 6. doi: 10.1089/hum.2017.155. [Epub ahead of print]. Michalakis S, Schön C, Becirovic E, Biel M (2017) Gene Therapy for Achroma-topsia. J Gene Medicine doi: 10.1002/jgm.2944. [Epub ahead of print]. Grimm C, Chen CC, Wahl-Schott C, Biel M (2017) Two-pore channels: catalyzers of endolysosomal transport and function. Front. Pharmacol. doi:10.3389/fpharm.2017.00045. Grimm C, Butz E, Chen CC, Wahl-Schott C, Biel M (2017) From mucolipidosis type IV to Ebola: TRPML and two-pore channels at the crossroads of endo-lysosomal trafficking and disease. Cell calcium 67:148-155.

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Ding XQ, Ma H, Biel M, Michalakis S (2017) Cellular Mechanisms of Cone De-fects in Cyclic Nucleotide-Gated Channel Deficiency. In Hemant Khanna (ed), Mo-lecular Basis of Neurodegenerative Disorders of the Retina, Bentham Science Pub-lishers, Chapter 8, pp 110-125. Alexander SP, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Dav-enport AP, Fabbro D, Spedding M, Striessnig J, Davies JA; CGTP Collaborators [incl. Biel M] (2017). THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview. Br J Pharmacol. Dec;174 Suppl 1:S1-S16. doi: 10.1111/bph.13882.

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Pharmacology PD Dr. Dr. Christian Michael Grimm Born 1975 in Würzburg/Bavaria, 1995-2000 study of pharmacy at Univ. Würzburg, 2004 PhD (Dr. rer. nat.) degree in the group of Prof. Dr. Günter Schultz, Institute for Pharmacology, Medical Faculty, FU Berlin, 2004-2005 Postdoctoral fellow at Harvard University (USA) and 2005-2009 Postdoctoral fellow at Stanford Universi-ty (USA) in the group of Prof. Dr. Stefan Heller, 2009-2011 Principal Scien-tist/Group Leader, Pfizer Pain Research Group, UK, 2011 PhD (Dr. phil.) degree in Philosophy (Univ. Kassel and Max-Planck Institute for the History of Science, Ber-lin), 2011 Group Leader (Habilitand), LMU Munich, Department of Pharmacology, Faculty of Pharmacy and Chemistry, in the group of Prof. Dr. Martin Biel, 2015 Privatdozent (Dr. rer. nat. habil.), SFB/TRR152 Project P04 Principal Investigator. Research Topics Endolysosomal cation channels (TRPML channels and Two-pore channels). Endo-somes and lysosomes are important cell organelles involved in trafficking and breakdown of different macromolecules. We investigate the functional roles of TRPML as well as Two-pore channels in endolysosomal trafficking, fusion, pH regulation and cation homeostasis and the consequences of channel loss or muta-tion for human pathology. Honors, Awards, Memberships 2016: NCL Foundation Research Award 2017: Care-for-Rare Foundation Award Extramural Research Funding 2016: NCL Foundation Research Award 2016: MLIV Foundation Grant (MDBR-17-120-ML4) 2017: Care-for-Rare Foundation Award 2017: DFG Einzelantrag GR-4315/2-1 Publications – Scientific Papers Chao, Y.-K., Schludi, V., Chen, C.-C., Butz, E., Nguyen, P., Müller, M., Krüger J, Kammerbauer C, Vollmar, A., Berking, C., Biel, M., Wahl-Schott, C., Grimm, C.#

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(2017) TPC2 polymorphisms associated with a human hair pigmentation phenotype result in gain of channel function by independent mechanisms. PNAS, 114(41):E8595-E8602. Castonguay, J., Orth, J.H.C., Müller, T., Sleman, F., Grimm, C., Wahl-Schott, C., Biel, M., Mallmann, R.T. Bildl, W., Schulte, U., Klugbauer, N. (2017) The two-pore channel 1 is required for efficient protein processing in early and recycling endosomes. Sci. Rep., 7(1):10038 Chen, C.-C., Butz, E., Chao, Y.-K., Grishchuk, Y., Becker, L., Heller, S., Slaugen-haupt, S., Biel, M., Wahl-Schott, C., Grimm, C.# (2017) Small molecules for early endosome specific patch-clamping. Cell Chem. Biol., 24(7):907-916.e4 Chen, C.-C., Chunlei, C., Fenske, S., Butz, E., Chao, Y.-K., Biel, M., Ren, D., Wahl-Schott, C., Grimm, C.# (2017) Patch clamp technique to characterize ion channels in individual intact endolysosomes. Nature Protoc., 12(8):1639-1658 Bobak, N., Feliciangeli, S., Chen, C.-C., Soussia, I.B., Bittner, S., Biel, M., Wahl-Schott, C., Grimm, C., Meuth, S.G., Lesage, F. (2017) Recombinant tandem of pore-domains in a weakly inward rectifying K+ channel 2 (TWIK2) forms active lysosomal channels. Sci. Rep., 7:649 Nguyen, P.*, Grimm, C.*, Schneider, L., Chao, Y.-K., Watermann, A., Ulrich, M., Mayr, D., Wahl-Schott, C., Biel, M., Vollmar, A.M. (2017) Two-pore channel function is crucial for migration of invasive cancer cells. Cancer Res., 77:1427-1438 Kilpatrick, B.S., Yates, E., Grimm, C., Schapira, A.H., Patel, S. (2016) Endo-lysosomal TRP mucolipin-1 triggers global ER Ca2+ release and Ca2+ influx. J. Cell Sci., 129:3859-3867 Beck, S., Henß, L., Weidner, T., Herrmann, J., Müller, R., Chao, Y.-K., Grimm, C., Weber, C., Sliva, K., Schnierle, B.S. (2016) Identification of entry inhibitors of Ebola virus Other Activities Reviewer for Nature Commun., Elife, Sci.Rep., Cell Calcium

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Pharmacology Priv. Doz. Dr. rer. nat. Stylianos Michalakis Born 1975 in Augsburg, 1995-1999 study of pharmacy at LMU Munich, 2003 PhD (Dr. rer. nat.) degree in the group of Prof. Dr. Martin Biel LMU Munich, 2003-2005 postdoctoral fellow at the Chair of Pharmacology for Natural Sciences LMU Munich, 2005-2011 Academic Counselor at LMU Munich, since 2011 Senior Aca-demic Counselor. November 2011 habilitation in pharmacology. Research Topics Gene therapy for inherited retinal diseases. Mechanisms of retinal degeneration. Epigenetic regulation of gene expression in retinal development and retinal degen-eration. Extramural Research Funding Excellence Cluster Center for Integrated Protein Sciences Munich (DFG and the Federal Ministry of Education and Research) Tistou and Charlotte Kerstan Foundation (RD-CURE Project) Research Support, Sanofi Deutschland GmbH (Gene Therapy for RP45) Publications – Scientific Papers Schön C, Sothilingam V, Mühlfriedel R, Garcia Garrido M, Beck SC, Tanimoto N, Wissinger B, Paquet-Durand F, Biel M, Michalakis S, Seeliger MW, RD-CURE Consortium. (2017) Gene therapy successfully delays degeneration in a mouse model of PDE6A-linked retinitis pigmentosa (RP 43). Hum Gene Ther, Epub 2017/12/08. Occelli LM, Schön C, Seeliger MW, Biel M, Michalakis S, Petersen-Jones S, RD-CURE Consortium. (2017) Gene Supplementation Rescues Rod Function and Pre-serves Photoreceptor and Retinal Morphology in Dogs, Leading the Way Towards Treating Human PDE6A-Retinitis Pigmentosa. Hum Gene Ther, Epub 2017/12/08.

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Seitz, I. P., Michalakis, S., Wilhelm, B., Reichel, F. F., Ochakovski, G. A., Zrenner, E., Ueffing, M., Biel, M., Wissinger, B., Bartz-Schmidt, K. U., Peters, T., Fischer, M. D., and for the, R. D. C. C. (2017) Superior Retinal Gene Transfer and Biodis-tribution Profile of Subretinal Versus Intravitreal Delivery of AAV8 in Nonhuman Primates. Investigative ophthalmology & visual science 58, 5792-5801 Schiffers, S., Ebert, C., Rahimoff, R., Kosmatchev, O., Steinbacher, J., Bohne, A. V., Spada, F., Michalakis, S., Nickelsen, J., Müller, M., and Carell, T. (2017) Quantitative LC-MS Provides No Evidence for m6 dA or m4 dC in the Genome of Mouse Embryonic Stem Cells and Tissues. Angewandte Chemie 56, 11268-11271 Reichel, F. F., Dauletbekov, D. L., Klein, R., Peters, T., Ochakovski, G. A., Seitz, I. P., Wilhelm, B., Ueffing, M., Biel, M., Wissinger, B., Michalakis, S., Bartz-Schmidt, K. U., Fischer, M. D., and Consortium, R.-C. (2017) AAV8 Can Induce Innate and Adaptive Immune Response in the Primate Eye. Molecular therapy : the journal of the American Society of Gene Therapy Ochakovski, G. A., Peters, T., Michalakis, S., Wilhelm, B., Wissinger, B., Biel, M., Bartz-Schmidt, K. U., Fischer, M. D., and Consortium, R.-C. (2017) Subretinal In-jection for Gene Therapy Does Not Cause Clinically Significant Outer Nuclear Layer Thinning in Normal Primate Foveae. Investigative ophthalmology & visual science 58, 4155-4160 Ding, X. Q., Ma, H., Biel, M., and Michalakis, S. (2017) Cellular Mechanisms of Cone Defects in Cyclic Nucleotide-Gated Channel Deficiency. in Molecular Bases of Neurodegenerative Disorders of the Retina (Khanna, H. ed.), Bentham Science. pp 110-125 Mühlfriedel, R., Tanimoto, N., Schön, C., Sothilingam, V., Garcia Garrido, M., Beck, S. C., Huber, G., Biel, M., Seeliger, M. W., and Michalakis, S.# (2017) AAV-Mediated Gene Supplementation Therapy in Achromatopsia Type 2: Preclinical Data on Therapeutic Time Window and Long-Term Effects. Front Neurosci 11, 292 Laprell, L., Tochitsky, I., Kaur, K., Manookin, M. B., Stein, M., Barber, D. M., Schön, C., Michalakis, S., Biel, M., Kramer, R. H., Sumser, M. P., Trauner, D., and Van Gelder, R. N. (2017) Photopharmacological control of bipolar cells restores visual function in blind mice. J Clin Invest 127, 2598-2611 Butler, M. R., Ma, H., Yang, F., Belcher, J., Le, Y. Z., Mikoshiba, K., Biel, M., Michalakis, S., Iuso, A., Krizaj, D., and Ding, X. Q. (2017) Endoplasmic reticulum (ER) Ca2+-channel activity contributes to ER stress and cone death in cyclic nucle-

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otide-gated channel deficiency. The Journal of biological chemistry 292, 11189-11205 Böhm, S., Riedmayr, L. M., Nguyen, O. N. P., Giessl, A., Liebscher, T., Butz, E. S., Schön, C., Michalakis, S., Wahl-Schott, C., Biel, M., and Becirovic, E. (2017) Peripherin-2 and Rom-1 have opposing effects on rod outer segment targeting of retinitis pigmentosa-linked peripherin-2 mutants. Scientific reports 7, 2321 Michalakis, S.#, Schön, C., Becirovic, E., and Biel, M. (2017) Gene therapy for achromatopsia. J Gene Med 19 Schön, C., Paquet-Durand, F., and Michalakis, S.# (2016) Cav1.4 L-Type Calcium Channels Contribute to Calpain Activation in Degenerating Photoreceptors of rd1 Mice. PloS one 11, e0156974 Schön, C., Asteriti, S., Koch, S., Sothilingam, V., Garcia Garrido, M., Tanimoto, N., Herms, J., Seeliger, M. W., Cangiano, L., Biel, M., and Michalakis, S.# (2016) Loss of HCN1 enhances disease progression in mouse models of CNG channel-linked retinitis pigmentosa and achromatopsia. Human molecular genetics 25, 1165-1175 Santos-Ferreira, T., Volkner, M., Borsch, O., Haas, J., Cimalla, P., Vasudevan, P., Carmeliet, P., Corbeil, D., Michalakis, S., Koch, E., Karl, M. O., and Ader, M. (2016) Author Response: Possibility of Cytoplasmic Transportation Between Do-nor-Host Cell Following Photoreceptor Transplantation. Investigative ophthalmol-ogy & visual science 57, 5336-5337 Santos-Ferreira, T., Volkner, M., Borsch, O., Haas, J., Cimalla, P., Vasudevan, P., Carmeliet, P., Corbeil, D., Michalakis, S., Koch, E., Karl, M. O., and Ader, M. (2016) Stem Cell-Derived Photoreceptor Transplants Differentially Integrate Into Mouse Models of Cone-Rod Dystrophy. Investigative ophthalmology & visual sci-ence 57, 3509-3520 Laprell, L., Hull, K., Stawski, P., Schon, C., Michalakis, S., Biel, M., Sumser, M. P., and Trauner, D. (2016) Restoring Light Sensitivity in Blind Retinae Using a Photochromic AMPA Receptor Agonist. ACS Chem Neurosci 7, 15-20 Becirovic, E., Böhm, S., Nguyen, O. N., Riedmayr, L. M., Koch, M. A., Schulze, E., Kohl, S., Borsch, O., Santos-Ferreira, T., Ader, M., Michalakis, S., and Biel, M. (2016) In Vivo Analysis of Disease-Associated Point Mutations Unveils Profound Differences in mRNA Splicing of Peripherin-2 in Rod and Cone Photoreceptors. PLoS Genet 12, e1005811

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Becirovic, E., Boehm, S., Nguyen, O. N. P., Riedmayr, L. M., Hammelmann, V., Schön, C., Butz, E. S., Wahl-Schott, C., Biel, M., and Michalakis, S.# (2016) AAV vectors for FRET-based analysis of protein-protein interactions in photoreceptor outer segments. Frontiers in Neuroscience 10 Auffenberg, E., Jurik, A., Mattusch, C., Stoffel, R., Genewsky, A., Namendorf, C., Schmid, R. M., Rammes, G., Biel, M., Uhr, M., Moosmang, S., Michalakis, S., Wotjak, C. T., and Thoeringer, C. K. (2016) Remote and reversible inhibition of neurons and circuits by small molecule induced potassium channel stabilization. Scientific reports 6, 19293 Tanimoto, N., Michalakis, S., Weber, B. H., Wahl-Schott, C. A., Hammes, H. P., and Seeliger, M. W. (2016) In-Depth Functional Diagnostics of Mouse Models by Single-Flash and Flicker Electroretinograms without Adapting Background Illumi-nation. Advances in experimental medicine and biology 854, 619-625 Patents PCT/EP2017/054229 "Gene therapy for the treatment of a disease of retinal cone cells" PCT/EP2017/054230 "Gene therapy for the treatment of a retinal degeneration dis-ease" U.S. Provisional Patent Application Serial No. 62/474,409 "Gene therapy for the treatment of CNGB1-linked retinitis pigmentosa" EP17176365.9 "Means and methods for treating neuropathic pain" EP17196567.6 "Novel AAV vectors for retinal gene therapy". Other Activities Editorial Board Member, Journal of Gene Medicine Associate Editor, Frontiers in Neuroscience Board Member, Graduate School Life Science Munich (LSM) Member of the Munich Center for NeuroSciences (MSN) Associated Member of the Graduate School of Systemic Neurosciences (GSN)

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Pharmacology Prof. Dr. med. Christian Wahl-Schott Born 1971 in Bielefeld/Nordrhein-Westfalen, 1991-1998 study of medicine at the Albert-Ludwigs-University in Freiburg and Ruprecht-Karls-Universität, Heidel-berg; 1997 MD degree in the group of Klaus Starke, Institut of Pharmacology and Toxicology, University of Freiburg; 1999-2000 research assistant at the Medizinische Klinik I, Klinikum der Universität München, Großhadern (chair: Prof. G. Steinbeck); 2000 full license to practice medicine (approbation); 2000-2007 postdoctoral fellow at the institute for Pharmacology for Natural Sciences, LMU Munich; 2007 habilitation. 2007-2013 W2 tenure track professor for molecu-lar pharmacology, LMU Munich, Since 2012 W2 tenure professor for molecular pharmacology, LMU, Munich. 2016 call for a W3 professorship for neurophysiolo-gy at the MH Hannover. Research Topics Physiology and pathophysiology of voltage gated Ca2+ channels and pacemaker channels in the cardiovascular system, the retina and the central nervous system. Functional role of Endo-lysosomal cation channels TPC1 and TPC2. Lysosomal patch clamp. Genetic mouse models. Cardiac electrophysiology and neurophysiol-ogy. In vivo cardiac electrophysiology. Honors, Awards, Memberships 2016 ADKA-Innovationspreis Klinische Pharmazie 2016 LMU Lehrinnovationspreis Member of the German Society for Pharmacology and Toxicology Member of the Bayerische Akademie für klinische Pharmazie Extramural Research Funding Collaborative Research Center 870 (DFG, German Research Council) “Assembly and Function of Neuronal Circuits”; project titles:” Regulation of the circadian sys-tem by HCN3 channels (project B05)” and “Information flow in a neuronal circuit coding for space (project B15)”

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Transregional Collaborative Research Center 152 (DFG, German Research Coun-cil) “TRiPs to Homeostasis: Maintenance of Body Homeostasis by Transient Re-ceptor Potential Channel Modules”; project title “Role of TPC2 in cellular signal-ing networks (project P06)” Research Grant (DFG, German Research Foundation), “The role of HCN channels for the synchronization process in the sinoatrial node of the heart “ Publications – Scientific Papers Butz E, Ben-Johny M, Shen M, Yang P, Sang L, Biel M, Yue DT, and Wahl-Schott C. Quantifying Macromolecular Interactions in Living cells using FRET 2-hybrid Assays. Nat. Protoc. 2016; 11:2470-2498. Becirovic E, Boehm S, Nguyen P, Riedmayr LM, Hammelmann V, Schön C, Butz ES, Wahl-Schott C, Biel M and Michalakis S. AAV vectors for FRET-based analy-sis of protein-protein interactions in photoreceptor outer segments. Front. Neurosci. 2016; 10:356 Barthmes M, Liao J, Jiang Y, Brüggemann A, Wahl-Schott C. Electrophysiological characterization of the archaeal transporter NCX_Mj using solid supported mem-brane technology. J. Gen. Physiol. 2016; 1467:485-96. featured article (Cover) Nguyen O.N.P, Böhm S, Gießl A, Butz E, Wolfrum U, Brandtstätter J.H., Wahl-Schott C, Biel M and Becirovic E. Peripherin-2 differentially interacts with cone opsins in outer segments of cone photoreceptors. Hum. Mol. Genet. 2016; 25:2367-2377 Fenske S., Pröbstle R., Auer F., Hassan S., Marks V., Pauza DH., Biel M., Wahl-Schott C. Comprehensive Multi-level in vivo and in vitro Analysis of Heart Rate Fluctuations in Mice by ECG Telemetry and Electrophysiology. Nat. protoc. 2016; 11:61-86. Tanimoto N, Michalakis S, Weber BH, Wahl-Schott CA, Hammes HP, Seeliger MW In-Depth Functional Diagnostics of Mouse Models by Single-Flash and Flick-er Electroretinograms without Adapting Background Illumination. Adv. Exp. Med. Biol. 2016; 854:619-25. Chao Y, Schludi V, Chen CC, Butz E, Nguyen OP, Müller M, Krüger J, Kammer-bauer C, Ben-Johny M, Vollmar A, Berking C, Biel M, Wahl-Schott C, Grimm C. TPC2 polymorphisms associated with a hair pigmentation phenotype in humans

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result in gain of channel function by independent mechanisms. Proc Natl Acad Sci U S A. 2017; 114:E8595-E8602 Castonguay J, Orth J, Müller T, Sleman F, Grimm C, Wahl-Schott C, Biel M, Mallmann RT, Bildl W, Schulte U, Klugbauer N The two-pore channel TPC1 is required for efficient protein processing through early and recycling endosomes Sci Rep. 2017; 7:10038 Chen CC, Cang C, Fenske S, Butz ES, Chao YK, Biel M, Ren D, Wahl-Schott C, Grimm CM. Patch clamp technique to characterize ion channels in individual intact endolysosomes. Nat. protoc. 2017; 12:1639-1658 Chen C, Butz E, Chao Y, Grishchuk Y, Becker L, Heller S, Slaugenhaupt SA, Biel M, Wahl-Schott C, Grimm C. Small Molecules for Early Endosome-Specific Patch Clamping. Cell. Chem. Biol. 2017; 24:907-916. Koch SF, Duong JK, Hsu CW, Tsai YT, Lin CS, Wahl-Schott CA, Tsang SH. Ge-netic rescue models refute nonautonomous rod cell death in retinitis pigmentosa. Proc. Natl. Acad. Sci. U S A. 2017; 114:5259-5264. Herrmann S, Rajab H, Christ I, Schirdewahn C, Höfler D, Fischer M, Trinks A, Fenske S, Gruner C, Wahl-Schott C, Stieber J, Biel M, Ludwig A. Protein kinase A regulates pain sensitization by modulating HCN2 channel activity in nociceptive sensory neurons. Pain. 2017; 158:2012-2024 Böhm S, Riedmayr LM, Nguyen ONP, Gießl A, Liebscher T, Butz ES, Schön C, Michalakis S, Wahl-Schott C, Biel M, Becirovic E. (2017) Peripherin-2 and Rom-1 have opposing effects on rod outer segment targeting of retinitis pigmentosa-linked peripherin-2 mutants. Sci. Rep. 7:2321 Bobak N, Feliciangeli S, Chen C, Soussia I, Bittner S, Biel M, Wahl-Scott C, Grimm C, Meuth S, Lesage F. Tandem of pore-domains in a Weakly Inward recti-fying K+ channel 2 (TWIK2) is a lysosomal channel Sci. Rep. 2017; 7:649 Nguyen ON, Grimm C, Schneider LS, Chao YK, Atzberger C, Bartel K, Water-mann A, Ulrich M, Mayr D, Wahl-Schott C, Biel M, Vollmar AM Two-Pore Chan-nel Function Is Crucial for the Migration of Invasive Cancer Cells. Cancer Res. 2017; 77:1427-1438

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Other Activities Grant reviewer for Deutsche Forschungsgemeinschaft, Wellcome Trust, Biotech-nology and Biological Sciences Research Council (BBSRC), Israel Science Foun-dation; Reviewer for PNAS, Science Signaling, Scientific Reports, EMBO journal, the Journal of Biochemical Chemistry, Biophysical Journal, FEBS Letters, Acta Physiologica Reviews in Neurosciences, BBA – Biomembranes, Frontiers in Phar-macology of Ion Channel.