Repressilator: “I’ll be back.”

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Repressilator: “I’ll be back.”

Is it possible to get a culture of E. coli cells to flash on and off with a green light?

A Synthetic Oscillatory Network of Transcriptional Regulators; Michael B. Elowitz and Stanislas Leibler; Nature. 2000 Jan 20;403(6767):335-8.

Repressilator: “I’ll be back.”

Is it possible to get a culture of E. coli cells to flash on and off with a green light?

YES!!

Clonal cells = clonal action?

Repressilator: “I’ll be back.”

Is it possible to coordinate a culture of E. coli cells to flash on and off with a green light?

NO!!

Repressilator: “I’ll be back.”

What worked and what did not?

How could you regulate the repressilator to be synchronous?

Alternative Representations

What if you don’t understand the molecular biology short hand, canthis information be presented in a different way to reach a wider audience?