REAKSI IMUN

7/23/2019 REAKSI IMUN

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PURNOMO SURYOHUDOYO

DEPT. OF BIOCHEMISTRYSCHOOL OF MEDICINE

AIRLANGGA UNIVERSITY


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IMMUNITY

INNATE (NATURAL) IMMUNITY

ACQUIRED (ADAPTIVE) IMMUNITY

Nonspecific

Does not epen on !nti"en # !nti$o% inte&!ction

Fi&st 'ine efence( !cts $efo&e !c)*i&e +!!pti,e- i*nit%

P&esent in p'!nts( in,e&te$&!tes !n ,e&te$&!tes

A'/!%s p&esent

Specific

Depens on !nti"en # !nti$o% inte&!ctions

On'% p&esent in ,e&te$&!tes t!0es tie to e,e'op


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ADAPTIVE

IMMUNORESPONSE

1. HUMORAL B LYMPHOCYTES

2. CELLULAR

T LYMPHOCYTESTc (Cytotoxic) CD8+

TH (Hele!) CD"+

TR (Re#$l%to!) CD"+

T Cell Receto! (TCR)M%&o! Hi'toco%tiility Colex !otei*' (MHC) MHC ( HLA ) MHC (HLA )


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CLO,AL SELECTO, THEORY

B LymphocytesDisplaying

Different lgs

Antigen

Antigen bind

to complementarylg

Proliferation

B Lymphocytes

displaying samelg

differentation

Plasma Cells

lg secreted


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Lymphocytes suspension from

unimmunised animal

Antigen (A) imbedded in gelatin

wash

Digest with enzyme and resuspend

Place in culture medium & obsere

under microscope

Add Antigen AAdd Antigen B

!o Proliferation Proliferation

P"##$ #$ CL#!AL %LC'#! '#"*


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IMMUNOGLOBULIN (Ig)

inge "egionCleaage by

Papain

+ $ab

+ $c

, heay dhain - , ariable domainL , light chain C , constant domain C# , carbohydrate

, disuliphide lin.$ab/ , antibody binding fragment$c/ , crystralline fragment

(does not bind Ab)L Chain ,

(lambda0 or ( .appa) Chain , 1 21 3 41 535+1 6

MMU,-LOBUL,S ARE ,AMED ATER TS H CHA,S /l#M0 l#D0 l# -0 l# A0 l# E


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OR-A,SATO, O - -E,ES

LCHA,

LCHA,

H LCHA,

7C

87A!

C HCHA,7 , membrane

(only transcribed in membrane

bound lg)

L , Leader(untranslated)

%ignal for translation in ribosomesbound to /"/ (membrane bound

& secreted proteins)


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-E,E REARRA,-EME,TPRETRA,SCRPTO,AL PROCESS,-MMU,O-LOBUL, L-HT CHA,

-ERM L,E D,A

MMU,O-LOBUL,

L-HT CHA,

LYMPHOCYTE D,A

MMU,O-LOBUL, SY,THESS , B LYMPHOCYTES

Y / -E,ES OR ARABLE RE-O,

3 / -E,ES OR 3O,,- SE-ME,TS

C / -E,E OR CO,STA,T RE-O,

CELL DERE,TATO, ( &-E,E REARRA,-EME,T)


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HCHA, -E,E REARRA,-EME,T


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ALLELIC EXCLUSION (1)

MMU,O-LOBUL, -E,ES H 4 CHA, / CHR 1"

L CHA, / CHR 5

L CHA, / CHR 15

H CHA, CHA,

CHA,

l# M

l# M


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ALLELIC EXCLUSION (2)


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S6TCH,- (MO,OU,CTO,AL LYMPHOCYTE)

S6TCH,- (BU,CTO,AL LYMPHOCYTE)


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MEMBRA,E &SECRETED .-.


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-E,ETC BASS OR A,TBODY DERSTY


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ARABLTY DUE TO 3 &D3 3O,,-

3U,CTO,SE7UE,CE

CODO,S-E,ERATED

A.A.

RAMESHT DUE TO3 D3 3O,,-

RAMESHT 6LL RESULT , A ,O,U,CTO,ALREARRE,-ED -E,E CELL DES


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B CELL S-,AL,-

URTHEREECT


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T CELL RECEPTOR ( TCR)

TCR CHA,S

TCR -E,ES


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MHC &MA3OR HSTOCOMPTABLTY COMPLE9 CLASS I & II

MHC i' :o$*; o* o't cellMHC i' o*ly :o$*; o* BLy


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PERPHERY

MEDULLA

CORTE9

T 4 LYMPHOCYTE DERE,TATO,


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A,T-E, PROCESS,- PRESE,TATO,Cytol%'ici!%l !otei*

,$cle%te;Ti''$e Cell

BLYMPHOCYTE

MACROPHA-ESA,T-E, PRESE,T,-

CELL (APC)

MHC

MHC

MHC


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T CELLS ,TERACTO,S


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Tc ,TERACTO,

TAR-ET CELL

TAR-ET CELL

Tc PROLERATO,

CELL DES BYAPOPTOSS

CELL DES BY ,ECROSS


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T HELPER ,TERACTO,

CELL MEDATED MMU,TY (DTH) HUMORAL MMU,TY


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T HELPER (T CD"+) ,TERACTO,


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RE-ULATORY T CELL (TR)


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B CELL ,TERACTO, (1)T CELL ,DEPE,DE,T A,T-E,>

> ALSO CALLED / THYMUS ,DEPE,DE,T A,T-E,


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B CELL ,TERACTO, (2)T CELL DEPE,DE,T A,T-E,>


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T CELL S-,AL,-


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