Prostate Artery Embolization Early US Trial Results

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Sandeep Bagla, MD Cardiovascular & Interventional Radiology Inova Alexandria Hospital. Prostate Artery Embolization Early US Trial Results. Key Points. PAE is effective in Significantly reducing the symptoms of an enlarged prostate (BPH) - PowerPoint PPT Presentation

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Prostate Artery Embolization Early US Trial ResultsSandeep Bagla, MDCardiovascular & Interventional RadiologyInova Alexandria HospitalKey PointsPAE is effective in Significantly reducing the symptoms of an enlarged prostate (BPH)Also effective in Significantly improving the Quality of Life in just 4 weeksNo minor or major complications related to the procedureWelcome news to millions of US menFirst prospective US trialPrincipal Investigator: Sandeep Bagla, MDInova Alexandria Hospital Alexandria, VATrial Start Date: Jan 2012 and estimated complete enrollment May 2013.

Background20m Men >50% over 50>80% over 80Not a matter of if, but when

Symptoms of BPH: LUTSUrinary FrequencySudden Urge to UrinateFrequent nighttime urinationWeak StreamFeeling as if bladder is not emptyComplications included weakened bladder, bladder stones, recurrent infections, urinary blockage.Rationale for new therapyRisks for standard procedure such as TURP, laser or microwave include: ImpotenceUrine leak or IncontinenceBleedingPain and Stricture/NarrowingInfection2m men avoided therapy

Minimally Invasive TherapyInterventional Radiologists

BeforeAfterStudyEnrolled 30 patients > 50 yrs oldModerate or Severe Symptoms of BPHFollow the patients for 2 years and assess for safety and measure the response to treatment21/30 patients have been treated so farDemographicsMean Age: 67 years oldAverage AUA Score: 25.2Mean Quality of Life Score 5.7Average Prostate Volume: 77 cc

Clinical Results (n=18)94% of patients had a significant decrease in symptoms from an enlarged prostateQuality of Life significantly improved in just 4 weeksSome men stopped prostate related medication altogether. Safety ResultsNo Minor or Major ComplicationsNo Urologic Complications includingImpotenceBleedingInfectionUrine Leak/Incontinence

Long Term OutlookPAE works in reducing symptoms, improving QoL and is safeIt can potentially eliminate the need for daily medicationsPatients will be followed for two years to assess for long term resultsOverseas results from 1-3 year followup are promising. Future trials comparing to other therapies are planned