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Processed Amniotic Processed Amniotic Membrane Membrane AllograftsAllografts
Amniotic Membrane AllograftsAmniotic Membrane Allografts
What Is Human Amniotic Membrane?What Is Human Amniotic Membrane?
• A unique, avascular membrane separating the mother from the fetus.
• Provides an incubating environment promoting cellular differentiation.
• Provides an immunological barrier to prevent “foreign body” rejection.
Anatomical Profile: AMAnatomical Profile: AM
Anatomy of the Ocular SurfaceAnatomy of the Ocular Surface
(1) Conjunctival Epithelium
(2) Corneal Epithelium
(6) Limbus – Stem Cells
History of AM in OphthalmologyHistory of AM in Ophthalmology
• De Rotth. conjunctival defects (1940).• Lavery. lime burn of conjunctiva and cornea (1946).• Sorsby et al. caustic soda burns (1947).• ALLOTRANSPLANTAT [late 80’s USSR->Venezuela, DR]
• Batlle and Perdomo. Conjunctival substitute with placental allotransplant. Scientific Poster 25. American Academy of Ophthalmology meeting. Chicago, IL USA. October 1993.
• Kim and Tseng. Transplantation of preserved human amniotic membrane for surface reconstruction in severely damaged rabbit corneas. Cornea 14:473-84, 1995. [
Surgical Indications: AMSurgical Indications: AM
• Pterygium Excision• Corneal Ulcerations/Perforations• Chemical/Thermal Burns• Bullous Keratopathy• Ocular Dermoids/Tumors• Fornix Reconstruction/Symblepharon• Stem Cell Transplants
PterygiumPterygium
• A mutated growth on the surface of the eye
• Requires surgical excision and placement of graft
Corneal Ulcerations/perforationsCorneal Ulcerations/perforations
• A break or defect in corneal epithelium
• Often secondary to other systemic diseases.
Chemical/thermal BurnsChemical/thermal Burns
• Chemical burns often caused by alkali
• Potentially devastating trauma to surface of the eye
• Limbal graft possibly indicated
Bullous KeratopathyBullous Keratopathy
• Edema of the corneal endothelium
• Very common and usually affects individuals over 50 years of age.
Dermoid/tumor RemovalDermoid/tumor Removal
• Benign congenital tumors containing foreign tissue
• Commonly found at the limbus
Fornix ReconstructionFornix Reconstruction
• Fibrous tract that connects bulbar conj to conj of eyelid
• Secondary to other acquired or traumatic conditions
• Required reconstruction of ocular surface and eyelids
Surgical Techniques: Amt/pterygiumSurgical Techniques: Amt/pterygium
AmbiodryAmbiodry22 Overview Overview
• Tested & Safe• Dehydrated• Terminally Sterilized• Strict, quality-
controlled protocols• Device-like quality
AmbioDry: Safe & ViableAmbioDry: Safe & Viable
•Intact epithelial cell layer
•Intact dense connective, basement membrane
•Presence of loose fibroblast network
AmbioDry: Logistical FeaturesAmbioDry: Logistical Features
• Storage: Room-temp• No freezer required• No dry ice shipments• Simple prep: No soaks or rinses• IOP Customer Service: 24 Hrs/7 Days
AmbioDry: Surgical AdvantagesAmbioDry: Surgical Advantages• Substrate-free• Dry-state handling & trimming• Visual orientation identification• No tears or buttonholes• Device-like tissue quality
AmbioDry ConfigurationsAmbioDry Configurations
• 1 x 2 cm
• 2 x 3 cm
• 4 x 4 cm
Reimbursement Codes
Supply code: V2790
CPT code: 65780 ocular surface reconstruction; Amniotic membrane transplantation
AmbioDry & TisseelAmbioDry & Tisseel
The sutureless approach to eye surgery.
Fibrin (biological) adhesive
Eliminates sutures
Reduces surgical time
Improved patient care
Better healing
AmbioDry & Tisseel VideoAmbioDry & Tisseel Video