1. INDUSTRIAL CHEMICAL PROCESS MATERIAL & ENERGY BALANCE
ASSIGNMENT2 Question 10
2. GROUP MEMBERS
MUHAMAD NORULAKMAL B. AB MALIK.
MASURI KAMA BT KAMARUDDIN SHAH.
CHARMINE CHEALSEA JHONNY.
3. INTRODUCTION
The bark from the willow treeSalix Albacontains high levels of
salicin, the glycoside of salicylic acid.
1853, French chemist Charles F. Gerhardt synthesized a
primitive form of aspirin, a derivative of salicylic acid.
1897 Felix Hoffmann, a German chemist working at the Bayer
division of I.G. Farber, discovered a better method for
synthesizing the drug.
4. WHAT IS ASPIRIN?
Aspirin is the general name for acetylsalicylic acid
(ASA).
The synthetic drug was developed as an analgesic
(painkiller).
It was the first NSAID (nonsteroidal anti-inflammatory drug),
and probably still the most effective.
it is also the trademark of the drug produced by Bayer in
Germany.
in other places the term aspirin refers to ASA by itself or as
an ingredient in other drugs.
5. SYNTHESIZING ACETYL SALICYLIC ACID
To synthesize aspirin,
salicylic acid will be combined with acetic anhydride.
small amount of phosphoric acid added as catalyst.
Reaction:
6. SYNTHETIC ASPIRIN
Synthesis from petroleum
7. INDUSTRIAL SCALE SYNTHESIS 8. CURRENT USES OF ASPIRIN
Over-the-counter pain relief, especially for headaches.
Reduction of swelling and inflammation in arthritis and
injuries.
Anti-coagulant given to sufferers of heart attack.
Can reduce severity of heart attack if taken at first
symptoms.
Recovery after cardiovascular surgery.
Treatment of rheumatoid arthritis, osteoarthritis and other
rheumatoid diseases.
9. QUESTION 10
Using data from the literature, design a small pilot-plant-size
process for producing 5 kg of aspirin per hour, by the reaction of
salicyclic acid with acetic anhydride.(note: Your design should
include a flow diagram, plus a complete material and energy
balance).
10. FLOW SHEET DIAGRAM 11. MATERIAL BALANCE
Basis 5kg/hr of Aspirin production
Summary of calculation:
12. ENERGY BALANCE ON REACTOR 13. DATA FOR CALCULATION 14.
CALCULATION SUMMARY 15. ENERGY BALANCEON COOLER TANK 16.
CALCULATION SUMMARY 17. ENERGY BALANCE ON FILTER 18. CALCULATION
SUMMARY 19. TOTAL ENERGY BALANCE
