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Resistance Training Improves Muscle

Function and Body

Composition in Patients With

Hyperthyroidism

Dibacakan oleh :

Rene Pradnasurya

Pembimbing :

Dr. Juanita Langi, SpPD

Journal reading

Arch Phys Med Rehabil Vol 87, Aug 2006

Bousquet-Santos K, et al.


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HYPERTHYROIDISM = PATHOLOGIC syndrome(tissue exposed to excessive amounts ofcirculating thyroid hormone)

Thyroid hormones regulates many physiologicfunction : energy and heat production,

synthesis of proteins,

muscle function,etc

Symptoms : Fatigue,

Tremor,

Weight loss,

General muscle weakness, etc2


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Skeletal muscle dysfunction compromise

abilities to perform activities

Hyperthyroidism causes 40% of muscle

protein breakdownmuscle mass

Medical treatment is effective to improvemuscle function BUT it is time dependent &

may not be achieved up to 1 year, AND

MUSCLE ENDURANCE is not improved

Muscle endurance closely related to

perform daily activities

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Resistance training = voluntary activation of

specific skeletal muscles against external

resistance effect in hyperthyroidism hasnever been studied

The purpose of study = to evaluate the effectof resistance training in the recovery of

skeletal muscle performance & body

composition in patients with hyperthyroidismwho were currently under medical treatment.

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METHODS

PARTICIPANTS 22 Graves disease patients

Sedentary

Clinical diagnosis & laboratory confirmation

9 healthy volunteers

Age & sex matched

Sedentary ( not participated in exercise program for 6

months )

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STUDY PROTOCOL

Baseline evaluation + antithyroid therapy

Divided into 2 groups : Control group

Training group

Reevaluated after 16 weeks

OUTCOME MEASURES:

Skeletal muscle performance

Strength Endurance

Body composition

Height, weight, skinfold thickness

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RESISTANCE TRAINING

Twice a week for 16 weeks ( interval min. 24 hrs )

3 sets of 7 maneuvers each ( 8 10 repetitions ) 2 leg knee extension

Righ & left knee flexion

Ankle plantar flexion

Supine bench press

Right & left handgrip

Session was supervised, lasted 50 mins.

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RESULTS

6 patients was excluded ( 3 control, 3intervention group )

Hyperthyroid patients had lower baseline

overall strength values compared with healthysubjects

Both groups of patients showed increased

strength at the end of the study However, the training group achieved greater

values in the postevaluation

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The pattern of the results obtained in the

endurance tests was similar to that observed

in the strength evaluation For anthropometric values, both the control &

training groups gained weight after 16 weeks

but only the training group achieved valuessimilar to the healthy control group

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DISCUSSION

Skeletal muscle is a major target organ of

thyroid hormone

Hyperthyroidism causes progressive muscle

weakness because of overall decrease in

muscle mass

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Patients with hyperthyroidism presented with

lower baseline strengths compared with

healthy volunteers

There is an increase of 27% in muscle strength

after 16 weeks in patients undergoing only

medical treatment

Patients engaged in the resistance-training

program along with medical treatment had a41% increase in strength

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Muscular endurance did not reach values of a

control healthy group after medical treatment

Muscular endurance is more closely related to

the ability to perform some daily life activities

Achievement of the euthyroid state should notbe considered evidence that all aspects of

muscle function have been normalized

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Resistance training had a powerful effect on

muscle endurance

This type of exercise training could have

beneficial effects on the muscle performance

of hyperthyroidism patients

Patients with hyperthyroidism engaged in

resistance training have enhanced skeletal

muscle performance compared with patientsundergoing medical therapy alone

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CONCLUSIONS

Resistance training seems to accelerate therecovery of muscle performance in patients

with hyperthyroidism undergoing medical

treatment

Resistance training should be considered as an

appropriate part of the treatment of

hyperthyroidism, with a potential positiveimpact on the functional status & quality of life

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