Porcine Heterografts

Types of Grafts

Heterografts: tissues transferred from one species to an unrelated species (xenografts / zoografts)

Homografts: tissues transferred from one individual to another of the same species

Autografts: tissue trasnferred from one area to another of the same individual

What is a Porcine Graft?

Xenograft From domestic pig sacrificed at 6

months of age Split-thickness skin – 0.01 inches Preparation types:

Antibiotic & bleach soak then electron beam

Saturated with antiseptic solution or aldehyde starches

Biological Advantages

Augment host immune defence & decreased bacterial count

Re-establishes vapor barrierDecreased water & protein loss

Increased rate of epithelialization No apparent immune response

Clinical Advantages

Alleviates pain Protects cartilage, tendons, bone,

nerves Facilitates motion and mobility Avoidance of harvesting STSG Inexpensive and unlimited supply

Indications

Large wounds Areas difficult to close Partial closure and granulation

before delayed repair (avascular areas)

Flap or graft contraindicated

Contraindications

Known sensitivity to porcine products

History of multiple or serum allergies

Wounds with large amounts of eschar

Types of Porcine Grafts

PerforatedPromotes drainage

Non-perforatedCartilage or bone areasMinimizes air exposure and

deceases pain

Porcine Xenograft

E•Z Derm™Nonperforated

Porcine Biosynthetic Wound Dressing

Porcine Heterografts in Dermatologic Surgery and Reconstruction

Davis, DA and Arpey, CJDermatol Surg 2000;26:76–80

The End