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NON-PNEUMATIC ANTI-SHOCK GARMENT (NASG)POPPHI 2009 UPDATE POPPHI 2009 UPDATE
SUELLEN MILLER, CNM, PHDDIRECTOR, SAFE MOTHERHOOD PROGRAMS, BIXBY CENTER FOR GLOBAL REPRODUCTIVE HEALTH, UCSF
Presented by Carinne Meyer, MA, MPH
The NASG: Low-cost, Low Tech Life Saving Device
Update on Research
Nigeria: Pre-Post Study
(Completed) Egypt: Pre-Post
Study (Completed) Zambia/Zimbabwe:
Cluster Randomized Trial
(In Progress)
Nigeria Study (Mar. 04 – Nov. 08) Pre-intervention/intervention study design 12 referral hospitals in Northern and
Southern Nigeria
Entry criteria were OH of any etiology (> = 750 ml) and one clinical sign of shock.
Outcomes: mean measured blood loss and mortality.
Phase N=756
Pre-intervention /Standard Treatment
182
Intervention / NASG
574
Ongoing Collaboration
Egypt Study (June 06 – May 08)
Pre-intervention/intervention study design 2 referral facilities in Egypt
Entry criteria were OH of any etiology (> = 750 ml) and one clinical sign of shock.
Outcomes: mean measured blood loss, mortality, severe morbidities and extreme adverse outcomes.
Phase N=990
Pre-intervention /Standard Treatment
432
Intervention / NASG
558
Zambia/Zimbabwe RCT
Design: Cluster Randomized Trial
Funding: NIH and Gates Foundation
Data Coordination: WHO, RHRU
Data Management: Centro Rosario Estudios Perinatales (CREP) (Argentina) OpenClinica
Research Collaboration: University Teaching Hospital in Lusaka, Zambia and the University of Zimbabwe (UZ-UCSF RH Collaborative)
Why a RCT?
The RCT is designed to
determine if early application early application at the primary care level by midwives will IMPROVE MATERNALOUTCOMES.
Randomized Cluster Trial
ClinicsReferral Hospital
Site Clusters
Harare 12
Lusaka 12
Copperbelt 13
Study Design – Example Lusaka
Study Timeline
October 2007
October 2008
June 2008
October 2009
May 2009
Feb 2009
July 2009
LUSAKA – Phase
1
HARARE – Phase
1
LUSAKA – Phase
3
LUSAKA – Phase
2
HARARE – Phase
3
HARARE – Phase
2
COPPERBELT– Phase 3
COPPERBELT– Phase 2
COPPERBELT– Phase 1
Thank You.
