PHARMACOLOGY QUESTIONS SEMIFINAL

I. General pharmacology

1. Targets of drug action. Receptor proteins.

2. Quantitative aspects of drug-receptor interactions.

3. Efficacy of drugs. Dose-response curves. Drug antagonism.

4. Repeated drug administration and adaptive mechanisms.

5. Transportation of drug molecules in the body.

6. Absorption of drugs. Modes of drug administration.

7. Drug metabolism.

8. Enzyme induction and inhibition.

9. Distribution of drugs and plasma protein binding.

10. Excretion of drugs.

11. Pharmacokinetic parameters. Blood concentration-time curves.

12. Factors influencing drug effect.

13. Drug interactions.

14. Adverse effects of drugs.

15. Basics of clinical pharmacology.

II. Pharmacology of ANS and inflammation

1. Cholinergic transmission, cholinergic receptors and cholinomimetics.

2. Muscarinic-receptor antagonists.

3. Adrenergic transmission, pharmacology of catecholamines.

4. Directly and indirectly acting sympathomimetics.

5. Alpha-receptor blockers and drugs reducing noradrenergic transmission.

6. Beta-receptor blockers.

7. Drugs used in migraine and other headache therapy.

8. Local anesthetic agents.

9. Striated muscle relaxants.

10. Smooth muscle relaxants.

11. Histamine, antihistamines.

12. Non-steroidal anti-inflammatory drugs. Drugs used in gout.

13. Immunosuppressants and –modulators.

14. Glucocorticoids.

15. Pharmacology of the respiratory system.

III. Pharmacology of CNS

1. General anesthetic agents – inhaled anesthetics.

2. General anesthetic agents – intravenous anesthetics. Perioperative medication.

3. Pharmacology of morphine and endogenous opioids.

4. Semisynthetic derivatives of morphine and synthetic opioid drugs.

5. Anxiolytic and sedato-hypnotic drugs acting on benzodiazepine receptors.

6. Other anxiolytic and sedato-hypnotic drugs. Central muscle relaxants.

7. Typical antipsychotic drugs.

8. Atypical antipsychotic drugs.

9. TCA and MAOI antidepressants.

10. SSRI and newer antidepressants,

11. Mood stabilizers, anti-maniac agents

12. Drug dependence, drug abuse.

13. Psychomotor stimulants.

14. Hallucinogens, cannabis.

15. Ethanol and alcoholism.

16. Antiepileptic drugs.

17. Biochemical basis of neurodegenerative disorders. Drugs used in Alzheimer-disease.

18. Drugs used in Parkinson’s disease.