10
PnOlmacofuneh('s I ph aJmacoql,qnamlcs and In aco/r; atneSJ fhonnaCoktll eJlcs ( V -=r £1)Iutn. rf -/ the apparent val(.»le dA.f; r/J dAAfE/Xd UA. C01c'" ;- /lmt / . '. vcn.; OM Y vdl. Ccw?c ,. -';> V; InllYM. vrJUnc of (J),()/'(lbuh{)A -;> :: ()/; -;:> /Jr cal c. . / Oflcitl18 cJaJe 10 if /; tw;Pi' r / ( - ;f VIdvt - J,j x T /latrrJJ C -::= atata¥JCL ( c'f fbxt aml- 1 c1cP{ ctCt2J!£ t 10° eer,end,A Oi? chAJ (r en l'lme @ / G ( b hepah, bJa:Ju ff)JCu,( I:vJdlr'(f' O f -Ir._ J. . .a...vJ/· "I t I'- d" a'liJ.rJ. '/ dalf..lLLU;.. '? :' J' VJ. l anrt. 0',-"" J.Vfl .. £11 ."CTrMi r pc. mal txxit( oIuuCVIa. Il'l ·l:;.< a :..1 _ / . I.. -- I. ,/ "lU"! "' ... I .. , .... o.t. _ • -"" Intv(JJaA ran == (ft-at x IrAzu

Pharmacokinetics pharmacodynamics and drug monitoring in acute illness.pdf

Embed Size (px)

Citation preview

Page 1: Pharmacokinetics pharmacodynamics and drug monitoring in acute illness.pdf

PnOlmacofuneh('s I phaJmacoql,qnamlcs and ~_ mon/~ In aco/r; atneSJ

fhonnaCoktll eJlcs

( V -=r £1)Iutn. rf ~}rt..b()hOA

-/ the apparent val(.»le dA.f; r/J dAAfE/Xd UA.

C01c'" ;- /lmt / . '. vcn.; OM Y vdl. Ccw?c ,.

-';> V; ~ InllYM. vrJUnc of (J),()/'(lbuh{)A

-;> ~s :: ~ ()/; ft~ ~

~ -;:> /Jr calc. . /Oflcitl18 cJaJe 10 if/; tw;Pi' m~~ r / ( -

;f ~ VIdvt - J,j x T /latrrJJ

C -::= atata¥JCL

( V~ c'f fbxt aml-1c1cP{ ctCt2J!£t 10°

eer,end,A Oi? chAJ ( r en l'lme @ / G ( b hepah, bJa:Ju f~

ff)JCu,( I:vJdlr'(f'

~ IftfY~ O f -Ir._ J.. .a...vJ/· "It I'- d" a'liJ.rJ. '/ dalf..lLLU;.. .~ . '? :'J'VJ. l anrt. 0',-"" J.Vfl .. £11 ."CTrMi r pc.

mal txxit( oIuuCVIa. ~ 10~. Il'l ·l:;.<a :..1 _ ~ / ~,.~, ,. . I.. -- I.

,/ "lU"! "'... ~ I .. , .... o.t. _ •

-"" Intv(JJaA ran == S/~ (ft-at 'cCMC~ x IrAzu ~ ~.

Page 2: Pharmacokinetics pharmacodynamics and drug monitoring in acute illness.pdf

C teorClllCL ana vtflome r1u:itLboha.A -P ttlirIMU1e eltml/Yl hc« /Jatt - tIme .

L

- -Icnff/Il/J IIJ~ !k /i1CJt t:Kt el'l taA,l ~ ~

fXvrJll)ahaA 6 ~l .

4- half It ~ ~ 94-/. h:tJrJCi1oA S " It:: 9:;-/. "

-

cl:lme (dr 81V''l9 tl dtfj , fJ/ld IlCIHtL .AAt:/hv 4t IYlor;,oM !

Page 3: Pharmacokinetics pharmacodynamics and drug monitoring in acute illness.pdf

Prol:£/f) blndlf)!}

(rtnrJa.IiA{) en/If ()tJ~{)fJd drcJ(J . CtllfctO tm11b1:JtJro. . f/IIYb e!fic,t

/ '!J7etaldtLu:J / eluntnatrd.

Chan~ ImjXJfUJnt f at:q ~ >~/. /:ttnd.. e8! @atfa/fAA da(Jlacecl bf plibJt{/fX;1 .

• (Jt;l{;/A c ~ ) at/. alJ nh' OhCA blIJc/ ClLOYmIl . - -TT :::=:= ;! btnrbJ8 0(. /08 [albumll1]

aL/JomllJ < .208/ L ---P J'l&n#trUlt t /Ir:e CIJI)C~

· lxIflc rfrUf. (If!..IXJCCUN. ,pet/lie/me I f'hntf ~ I p~ ) '- burJ tx I aCId (lIf(CrJP~

l l' ClYJC~ In ttlNA? !

/f'QcI!Ca/# . Penl ~ - tb'A) /tttiClkt ,'. I. ItXXit1(9 t:/aJ

. IlmllJCy2h,/l/vtt, - naffOW t .lnc/Qx, - olnrat Ioarilrra D IYJOlfllct1a(J(Q. btf aet;mnm, r

All ylf~\~ /' i:J-

~.

c.P#t tl(; - can ~ cI1~ IVI ro)c ~ JhllIJ,( er h~ _.

- f PJtJfIa- 1 ejJlcb C ~ dia,... tIt.tIA I mic . J,e(ftr£ ~ v/f I(}/bo.aA I ~

Iju;.,( /l)1)t'W6" u;," / IZ:i -:.. tg/ morpf!IAe c'w J}; (if fGil/.l.

(PJaJrI /elk $)\ ~ /$J1 rIo ~ ~ ~dJ _.'. -,'"

Page 4: Pharmacokinetics pharmacodynamics and drug monitoring in acute illness.pdf

\

!lJarmacodl((1atn'CS ( JIuiI( of elfkb ()(J ~ .

• , '1

810RfASE, - awal (f/~ of ac/zt>1 of dfVB .

l o CNadtent id1 tlood tr b,cph':l8! == DGtA'I @ AJso blc:a;i p~ .Jo Of[p\ ~

~ ~hc IflfI.tIx - ltrJnsIent Io<ICt"1 lJl Y/lrlC -htsfo~).

1ktaflu/1r; Il7cU = mrrilan /oXiC " IYledI ~ e/ficl1tl! ( ~ dae

II/(J)) -IJ; cOJe{Jl; -'/ (Jmln~concbA j hlralelo lafX1'Jae. (JmllJcf11t/~

Page 5: Pharmacokinetics pharmacodynamics and drug monitoring in acute illness.pdf

~ If) Cft-!lCai tUne/)

~ Avolci aut - .6 mohllhf, blood floW, pH, /ldl {X1JJ nx:Izlb.

/Intlcho/llJf!{91CS , IJntaclds tieIaJt ~c epPtflrJ· ff»JotIJlQZVJeJ

OpiOLdJ

1Nl -7 Blood 11a.<> hDIf le. abl . Se.

IV -? teUaI5l£ • qaeA, et" 8/'11 1) dCIJ aAJor b --Y //Vo()"'" I r/~J?A£IN , l3Jso~gIP£ . ChemIcaL Inconpahblb/z{ -~ pll, oolvrnt elfic/J, tl1ha , ~1'11()/\

, .. J l f , I .".VI. I .. "

. Jmplt. dItp" , I}ttp CQ)t1 kI'

. &.fMgt fVmttr.( I7Iaf6 aauaJc, I bL aVlRCl L :

~.I

() Clrco/a~ (Qdvre Note"/{hu fo vital 01PflS• /'8taJlljl1l".

V to kLdmt ~t Shtnh"f.! 10 OV"tatmlut.lc:N4 flt.(JYJ ~ L VG-r~

-bewehoJ\ . ~ 10 la ttI -.=t(!» ~

® I1 ~ dOfAy)" t CJJoIlt OJ) tA.eU .

Nechan,cra ¥ellt -= flflirattxrau"f -= flfnOj) p '; ~/j,tCI /J4rQ.~

Page 6: Pharmacokinetics pharmacodynamics and drug monitoring in acute illness.pdf

. '. € fOi!!J-- 0 6~ V, @ Jb V4s

( 0 p Clt!Yanm.

I b tn:Ye efIia (J'J ~ that fj) ffJpd dtJ/nbo/oJ. .

~ 1'v, p({)J~ dlDJr,bv/w. tl12

(fEr) ClJ,7nJg I'" t /fet CQ1C" tI JDrYIR. L,? ~ teJpYJl(, bl{ I> @ offlntJLt - (akchd1oIYIIYlfA.

@ f/e{Xlhc ftll/VIe . i (

. {to/)') d4(btd. cI!vff - l'8nocatne I f1'J01Jhlfle" hJldtJUJ/OM.

I

, Phat>e / a/ftrJcd :> ptJate .2 iJrIoatUt . . LEts carf.l)pmri fXJYkt 10 tW8 rnetab. /

~ft¥TJe 11dobdJ(..YIA ~ dJt1lO 'i!1 M/dO Zdaw. .' ) -p /)() metalxlk/r;O lJ" "'Oh plQffnQ. CM" ~ !

Page 7: Pharmacokinetics pharmacodynamics and drug monitoring in acute illness.pdf

b /b'fYKJt'" CLOhnlf£.

/ Cteat/IJ/IX! cteevafla - fboe (jVIOG - ctet:lhl1lLt fJSJOt{ IlJflClafak..

()JtI:/A JOvndl (I, ~ frxr;rrtndldl eHfhltrilJ()A. Ifnpaur.tt In ~fQtlwe )

-Y (J1/rtX:xJM M!ChCJl)ISIfA ~ a,() mdDh. IJ It{ IIW ! .

SlfS /(okC( capIJaA(/.) -;:> f' llJlA) --:;> • ~ t VD --;:> t loadt"9 ne«t.£d..

I

CHA"gs IN fltCGP1o~

lack. Jh/YJ()/ohaA -"::> 1/ @ nlJlnbeo ::: t,JP-~ N

11" --9 "" I, :: OOWN -1?E(j..

lJ / ACI1 @ t fdt MII.

ItCtdOJIJ --9> ~Caech(//omlne @ o/fJl1lhf. ittpOthr/WJ/Q --;. 06@ affln"lf'

{)Rorr NoIJt7O/l,AJ6- mott 91ve IIfIaL ('Clte,t IUft

~ - (. emenltaJ. If /(),Q 7.lndt*/ UIIOJr.nd ,I ,~ - .£t clInIcal obs ~ (}r levels. ~

~1Y1fJ.tf III ()/J tIImrp cho"1- -/e\Ct<) 1ft£; ~ td.: ~, 1itrz. of ~ bJall.{

a~ [PfItK C~N1'£A1I()I.JS -y ~tIt/I.G OdhtjtlJmllJlj

:> Mf AN CONC J.:J "'" -5> 6r:nloff»CIt1 oIoJtmCtly

helXt mrwle trrxrJh !

A~ f/(JJ) iuM chM/f' /tU£({//) ---¥ 1o&" DJ If/II).,I 1VNtd( ~ Mta/J.It., fK;: I.IM!J

~ V?)'Nc. 0" rJeNT .' r

Page 8: Pharmacokinetics pharmacodynamics and drug monitoring in acute illness.pdf

.. .. ..

-7 ffcdahves

I Mt/cIJcJafAA @ 96/. ptM:IlI band. ~ 11 f prtSJa.n b1ndlne = t C/~aFal1(fl /lee.df) (irJmpeJ'JJO/orl{ ) .

al)(ftr/ metaJ;. If} rb.

PIOPO/Ol - n:ed C!JYJ ,er lUlahcu ihafA antUDfhuLCA

- /008 b"mlntU, tll,z IS -20/1

- 9a-i'. b:JuncI Al.8lJHIAJ + I!8c (ol1tlVf1lC / ~tJlkJJu/~· f"1,;tLtW.-;)

~ OptOlclS · feqtJJemtllh VOILf /0 fao .t . 1cieIrA?c£ l1l{J,d. . f /dr t1J1aI~ - pt. ctJ1h6lltd (/J beJ/fr. . f£thtrliMl, - /::ad ,/ • MtYlPHIN£ - me/ab. b:.f /lw

- b</G - II~ /tir/CI? ~ at/ich fhe:la~ .' - teml ;at/Uff :: CiavYJcJlahQ,t trlO'phlfll. ~ r .

-Ff;,. ,~.,Nt (, - flalf hme dtf). Of) tier"" rf In{brIaA. ) 2 [Ir/m/l?()J Cl?, = 6hcw .'!] ( !;tt no achle metabo/lfes.

8'4/. pl'li:eln /;t(M?(j .

Nd:abbf //W lIepahC r Ret1a/. /btl~- I,I/Ie e(ficI; !

M()sc:l.t-/f3Iaxanh

t~ Cf)n be 'f> 10 38'h~!

- etlIIlf fYJ()IJl/or

- etvll,f,Jlht),( (F aJmc()IlVW.) ptbJOII!P' In /xpCLhc ls" /em} /h,I(},-e .

Page 9: Pharmacokinetics pharmacodynamics and drug monitoring in acute illness.pdf

IInh arrhq I:IJmlcs

1(JJ?rX:'aUAe J t It>xtC1iLt In Ccf .J

( L ~C/er)rafJ{£lr ~ YOss In COICttac 'Ir Ilw!hIMC ,

t P(, aad dkicoprt:Jt:,w.. 111 ,dll(sJ prt>kcb .'

'fDXlCt/tt t bc..t P k; ~ Ca as, t 1f!j 2+

(;:"? S" := OIXf OI'fhf{thmo er block ,I

::> raft! If cC ~-S,.umc/lll (OY111J1CV) If :> S

, Ifk:laI, In tenal y /,w ~tI"'" PlfJ{]xfl) -Itke Iml1/()/J()leach~ facJor. --- ..:: (j11t1Jablt 1UJa'l.

AfJhhJOhcs / II/Atro,. tl. J h&,,'~, /rJt.c, ,: 1HO~'fW', Val1e l( geut CUf'JICaL I'elJPO()te QJSO' tc.ttJ,t peak tbds !

-~ ble, /(l)U ~ ae Inh,blotLf 10 ~ .

. '. Ootccrne ~ --:y SI'fjk cJo.Ll,-/ dOle

6erJc. neerJo l' tJor, tic ,.. Vo In 11/ !

;:> /3- /adam onhb,oh(A -";> c1L.OW .' -::> need NI:; ,,4- -5 10 tiJ()fI<.!.

8;IIIS :' r Vo J, c/U)ran Lt.. .

Page 10: Pharmacokinetics pharmacodynamics and drug monitoring in acute illness.pdf

Anhcoovulsanb (

Pbenf(JoIn m(i;a~ - sa/rralk. fl1SJctM f:tJuvJ .:. ..iet&Jfe .

Y hjernqme IncItxU:> (ea/ balb /uftr/r:(J).

/JR;l?CIxddat~ ( --

aml!10phftUvLe - 1lYf) t~

( - /Jalf1)w 7.1. (con;UotoxJ(, ) {£nrJu /Stnoklna/ ClmehdJ~ leAfthtom'l&fN4

V 10IAl e . . ... /l}CYC cILf/~ Ob DJeIa/>. tJ70n flOlAJ. ~CIl ~ 6 IntKpI/S.

• A1 '/ Il' . , ''10N(r~ OAIf., ., ..