Perforator-to-Perforator Musculocutaneous Anterolateral Thigh Flap for Reconstruction of a Lumbosacral Defect Using the Lumbar Artery Perforator as Recipient Vessel page 1
Perforator-to-Perforator Musculocutaneous Anterolateral Thigh Flap for Reconstruction of a Lumbosacral Defect Using the Lumbar Artery Perforator as Recipient Vessel page 2
Perforator-to-Perforator Musculocutaneous Anterolateral Thigh Flap for Reconstruction of a Lumbosacral Defect Using the Lumbar Artery Perforator as Recipient Vessel page 3
Perforator-to-Perforator Musculocutaneous Anterolateral Thigh Flap for Reconstruction of a Lumbosacral Defect Using the Lumbar Artery Perforator as Recipient Vessel page 4
Perforator-to-Perforator Musculocutaneous Anterolateral Thigh Flap for Reconstruction of a Lumbosacral Defect Using the Lumbar Artery Perforator as Recipient Vessel page 5

Perforator-to-Perforator Musculocutaneous Anterolateral Thigh Flap for Reconstruction of a Lumbosacral Defect Using the Lumbar Artery Perforator as Recipient Vessel

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  • Perforator-to-Perforator MusculocutaneousAnterolateral Thigh Flap for Reconstructionof a Lumbosacral Defect Using the LumbarArtery Perforator as Recipient VesselMarc A.M. Mureau, M.D., Ph.D.1 and Stefan O.P. Hofer, M.D., Ph.D., F.R.C.S.(C)1,2

    ABSTRACT

    Reconstruction of large-sized lumbosacral or sacral defects often is not possibleusing local or regional flaps, making the use of free flaps necessary. However, the difficultyof any microsurgical procedure in this region is complicated by the need to search forpotential recipient vessels to revascularize the flap. In the present case, a free musculocuta-neous anterolateral thigh flap to cover a large-sized and deep lumbosacral defect was used.Arterial anastomosis was performed, connecting the cutaneous anterolateral thigh (ALT)perforator to the perforator of the second lumbar artery. In this fashion, the arterialcirculation through the flap was flowing reversely through the muscle. The concomitantvein of the descending branch of the lateral circumflex femoral artery was hooked up to thethoracodorsal vein using a long interposition vein graft because the perforator of the secondlumbar vein was too small. Postoperative healing was uneventful. In conclusion, asuccessful reconstruction of a lumbar defect has shown that local perforators in the lumbararea may be accessible for easier perforator-to-perforator anastomoses and that themuscular part of the musculocutaneous ALT flap can survive on retrograde arterialperfusion from a perforator of the skin island.

    KEYWORDS: Lumbosacral defect, perforator, free flap, recipient vessel

    Reconstruction of large-sized lumbosacral orsacral defects can often be difficult because of theanatomic features of the local tissue: it is relatively thick,adheres strongly to the underlying layers, and is relativelyinelastic.1 Therefore, attempts to cover such large defectsusing local or regional flaps often will result in necrosis offlap edges, caused by excessive tension with consequentrisk of infection and unstable wounds.1 Consequently,free flaps will often be necessary to reconstruct large-sized defects in the lumbosacral or sacral area. However,

    the difficulty of any microsurgical procedure in thisregion is complicated by the need to search for potentialrecipient vessels to revascularize the flap. Some havetried to overcome this problem by connecting free flapsto the thoracodorsal1,2 or femoral vessels1,3,4 usinginterposition vein grafts or loops; others have usedthe superior gluteal,4,5 inferior gluteal,6 or intercostalvessels.7

    In the present case, a free musculocutaneousanterolateral thigh (ALT) flap was used to cover

    1Department of Plastic and Reconstructive Surgery, Erasmus MedicalCenter Rotterdam, Rotterdam, The Netherlands; 2Division of PlasticSurgery, University of Toronto, University Health Network, Toronto,Ontario, Canada.

    Address for correspondence and reprint requests: Marc A.M.Mureau, M.D., Ph.D., Department of Plastic and ReconstructiveSurgery, Erasmus Medical Center Rotterdam, P.O. Box 2040, 3000

    CA Rotterdam, The Netherlands.J Reconstr Microsurg 2008;24:295300. Copyright # 2008 by

    Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY10001, USA. Tel: +1(212) 584-4662.

    Accepted: September 10, 2007. Published online: June 11, 2008.DOI 10.1055/s-2008-1080532. ISSN 0743-684X.

    295

  • a large-sized and deep lumbosacral defect (25 108 cm). Arterial anastomosis was performed connectingthe cutaneous ALT perforator to the perforator of thesecond lumbar artery. The concomitant vein of thedescending branch of the lateral circumflex femoralartery was hooked up to the thoracodorsal vein using along interposition vein graft because the perforatorof the second lumbar vein was too small. To our knowl-edge, this procedure has not been previously described inliterature.

    CASE REPORTA 43-year-old male patient presented with a large-sizedand deep lumbosacral defect after irradical resection of apulmonary metastasized small blue round cell sarcoma,not otherwise specified. A few months preoperatively, hehad received six cycles of induction chemotherapy(adriamycin/ifosfamide and doxorubicin/ifosfamide/eto-poside) with a good response, after which en block tumorresection and a dorsal L2 to S1 spondylodesis usingcancellous bone grafts were performed. Postoperatively,he had received local radiotherapy (total cumulativedose: 39 Gy), complicated by a deep infection of thedorsal spondylodesis for which abscess drainage had tobe performed, resulting in a deep lumbosacral defectwith exposed hardware (Fig. 1). In addition, his medicalhistory included multiple sclerosis (since 1983) withparaplegia (since 1998) and a pulmonary embolism.

    After two additional debridements and high-doseintravenous antibiotic treatment, the patient was sched-uled for radical excision of the radiodermatitis areaand reconstruction with a local pedicled lumbar arteryperforator (LAP) flap. Preoperatively, the left perforatorof the second lumbar artery was localized using ahandheld Doppler (Multidopplex II, Huntleigh Health-care, Cardiff, UK). After radical debridement, the defect

    measured 25 10 8 cm, and the subcutaneous fatthickness of the LAP flap measured only a few centi-meters (Fig. 2). Therefore, it was decided to harvest afree musculocutaneous ALT flap from the left upper legincluding the total vastus lateralis muscle to obliteratethe entire lumbosacral cavity. In search for more adjacentrecipient vessels, the cutaneous perforators of the secondlumbar artery and concomitant veins were dissectedthrough an exploring incision, and the arterial flow waschecked and found to be adequate (Fig. 3). Because theperforator of the second lumbar artery was rather small(1 mm) and did not match the descending branch ofthe lateral circumflex femoral artery (3.5 mm), it wasanastomosed end-to-end to the most cranial of threecutaneous perforators of the ALT flap (after it wasdissected and transected). In this fashion, the arterialcirculation through the flap was flowing reversely

    Figure 1 Chronic lumbosacral defect after previous de-

    bulking of a small blue round cell sarcoma followed by a

    dorsal L2 to S1 spondylodesis and postoperative radiother-

    apy (39 Gy) complicated by a deep abscess formation, which

    had to be drained.

    Figure 2 Lumbosacral defect after radical debridement

    measuring 25 10 8 cm. The proximal base of a left-sidedlumbal artery perforator (LAP) flap is flipped, laterally expos-

    ing the perforating vessels of the second lumbar artery and

    veins. Please note that the LAP flap is only a few centimeters

    thick, making it unsuitable to obliterate the defect.

    Figure 3 Magnification of the perforating vessels of the

    second lumbar artery and veins. The deep fascia and latissi-

    mus dorsi muscle fibers are split, exposing the left erector

    spinae muscle through which the lumbar perforating vessels

    run.

    296 JOURNAL OF RECONSTRUCTIVE MICROSURGERY/VOLUME 24, NUMBER 4 2008

  • through the muscle (Fig. 4). Next, an attempt was madeto anastomose one of the concomitant perforating veinsof the second lumbar vein to the vein accompanyingthe arterial cutaneous ALT perforator. However, after15 minutes, the flap became severely congested despite arevision of the venous anastomosis. The venous con-gestion resolved after opening the concomitant vein ofthe descending branch of the lateral circumflex femoralartery. Therefore, the latter vein was connected to thethoracodorsal vein using a 35-cm-long greater saphe-nous vein interposition graft, which was subcutaneouslytunneled to the left axilla (Figs. 4 and 5).

    Postoperatively, the patient was nursed in a rightdecubital position for 4 weeks and high-dose intravenousantibiotic treatment was continued. After 4 weeks, thepatient was allowed to sit in his wheelchair with adjustedbackrest, and after 6 weeks, he was allowed to lift himselfusing both arms forcefully to make transfers. All wounds

    healed uneventfully (Figs. 6 and 7), and the patient waskept on oral antibiotics for a period of 6 weeks.

    DISCUSSIONLarge-sized lumbosacral or sacral defects are encoun-tered relatively infrequently. These large defects some-times can be closed using large bilateral myocutaneous or

    Figure 4 Schematic drawing of microsurgical anasto-

    moses and blood flow directions of perforator-to-perforator

    myocutaneous anterolateral thigh flap. LAP, lumbal artery

    perforator; ALT-P, anterolateral thigh flap perforator; VL,

    vastus lateralis muscle; DB-LCFA, descending branch of

    lateral circumflex femoral artery; VG, vein graft; TDV, thor-

    acodorsal vein.

    Figure 5 Direct postoperative result after reconstruction

    of the lumbosacral defect with a myocutaneous anterolateral

    thigh free flap. The perforator of the second lumbar artery

    was anastomosed to the most cranial cutaneous perforator

    of the anterolateral thigh flap. The concomitant vein of the

    descending branch of the lateral circumflex femoral artery

    was connected to the thoracodorsal vein using a 35-cm-long

    greater saphenous vein interposition graft, which was sub-

    cutaneously tunneled to the left axilla.

    Figure 6 Result 3 weeks postoperatively, showing a small

    fistula at the caudal side of the flap, which closed sponta-

    neously.

    Figure 7 End result 4 months postoperatively, showing a

    completely healed wound without signs of a chronic or deep

    infection.

    PERFORATOR-TO-PERFORATOR MUSCULOCUTANEOUS ALT FLAP/MUREAU, HOFER 297

  • fasciocutaneous transposition flaps if the gluteal vesselsare intact and the area has not been irradiated previously.A disadvantage of traditional myocutaneous flaps, aswith the gluteus maximus V-Y advancement flaps, isthe