Overview:

InnateImmune Response

InflammationRecruitment from the bloodstream

InflammationPhagocytosis of a bacterium

Inflammation

Inflammation

Soluble Molecules•Proinflammatory cytokines:

•IL-1•TNFa

•Antimicrobial peptides

•Acute phase response (APR) and acute phase response proteins•complement proteins•C-reactive protein (CRP)•Mannose-binding lectin (MBL)

Receptors Detect Infection

Receptors Detect Infection•Classification of PRRs:

a) signaling b) endocytic•Membrane bound:

Toll-like receptors (TLR)C-type lectin receptor (CLR)Scavenger receptors (SRs)Lipopolysaccharide receptor (LPR)

•Cytoplasmic:NOD-like receptors (NLR)

•Secreted:Mannose-binding lectin (MBL)Complement receptorsC-reactive protein (CRP)LPS-binding protein (LBP)

Receptors Detect Infection

Toll-like Receptors

Toll-like Receptors

Cells involved in innate immunity•Neutrophils

•Macrophages

•Dendritic cells

•Natural killer cells

Signal Transduction

Signal Transduction

Signal Transduction

Signal Transduction

Signal Transduction

Ubiquity of Innate Immunity