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Osteogenesis imperfecta (compression fractures)

Osteogenesis imperfecta (compression fractures). OI-blue sclera

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Page 1: Osteogenesis imperfecta (compression fractures). OI-blue sclera

Osteogenesis imperfecta (compression fractures)

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OI-blue sclera

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Osteopetrosis(Albers-Schonberg)-osteoclast defect, Inc. bone mass but still brittle

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Osteochondromatosis

Risk for malignancy?

Chondrosarcoma

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Osteochondromatosis

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Osteochondromatosis

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Osteochondromatosis

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Osteochondromatosis w/ cartilage cap

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TB in the spine (eponym)? Pott’s Dz

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TB-granulomas, giant cells

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Calcium stain-Normal Bone

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Ca stain-Osteoporosis (Loss of Bone density)

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Thick skull? Paget’sHearing loss, Inc. serum Alk Phos, Inc. urine hydroxyproline

Sxs?

At Risk?

osteosarcoma,

CHF

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Fibrous dysplasia of the rib

Polyostotic FD + Café au Lait & Early Puberty?McCune-Albright

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Fibrous Dysplasia-too much stroma

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Osteoid osteoma

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Osteoid osteoma

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Osteoblastoma

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Osteosarcoma-Codman’s Triangle #1 primary mal bone

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Osteosarcoma-kids with Rb at risk, Chr 13 del

Adults with previous radiation or Paget’s

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Osteosarcoma

Telangiotic type

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Osteosarcoma-Telangiotic type

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Osteosarcoma-appendicular bones

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Chondroma

Oiler’s-multi (one side

Of the body)

Mafucci’s-multi & hemangioma

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Chondroma

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Chondrosarcoma-axial bones

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Chondrosarcoma-#2 primary mal bone

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Chondrosarcoma

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Chondrosarcoma-single mitosis is Dx

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Ewing’s sarcoma-t(11,22)

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(PAS+ ) Ewing’s

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Liposarcoma-cell type?

Flouret cell (multinucleated lipoblast)

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Liposarcoma type? Well-diff/low grade

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Liposarcoma type? Myxoid most common t12,16

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Liposarcoma-myxoid signet ring cells

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Liposarcoma-Pleomorphic w/ Giant lipoblast

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Liposarcoma-Round cell

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Liposarcoma-ugly looking isn’t it?

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Mal Fibrous Histiocytoma-#1 soft tissue mal

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Mal Fibrous Histiocytoma-giant cells

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Mal Fibrous Histiocytoma

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Mal Fibrous Histiocytoma

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Synovial Sarcoma-biphasic epitheloid and spindle cell

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Synovial Sarcoma-biphasic epitheloid and spindle cell

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Synovial Sarcoma-not synovial tissue

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Synovial Sarcoma