Opportunistic Infections and AIDS

Andy Catanzaro, MD

Infectious Diseases

Unity Health Care, Inc

Objectives

Recognize the relationship between CD4 and Opportunistic Infections

Recognize common Opportunistic Infections

Understand prophylaxis for Opportunistic Infections

Clinical Case

HIV Pathogenesis

CD4 level and Opportunistic Infections

Bedside methods to establish CD4 Count

Clincal Case: Thrush, wt loss

Severe Opportunistic Infections

Most Common

PCP pneumonia

Candida Esophagitis

Cryptococcal Meningitis

Toxoplasmosis

CMV Retinitis

Mycobacterium avium

Prophylaxis for Opportunistic Infections CD4 <200

PCP pneumonia prophylaxis Trimethoprim/Sulfamethoxasole

(Bactrim/Septra) Dapsone Daily dosing or three times a week

CD4 <100 Mycobacterium Prophylaxis

Zithromax (Azithromcyin) 1200 mg daily

Clinical Case

Conclusions

AIDS Opportunistic infections occur as CD4<200

Opportunistic infections occur commonly Prophylaxis for AIDS conditions or

CD4<200 with Bactrim/Septra daily or TIW CD4<100 with Zithromax weekly