16

Omeprazoie prevents ulcer recurrence Maintenance therapy with omeprazole

significantly reduced duodenal ulcer relapse compared with placebo.

Relapse occurred in 16/65 patients who received omeprazole 20mg 3 times weekly, in 19/64 patients who received omeprazole to mgjkgjday and in 52/66 patients who received placebo, for 6 months. Ulcers had been previously treated with omeprazole. 55 of the patients who relapsed had openly received omeprazole 20 mgjday and healing had occurred in 54; these patients received maintenance omeprazole therapy and ulcer recurrence occurred in 10 patients (all were smokers). No omeprazole-related adverse effects were reported. Lauritsen K, Andersen BN, Laursen LS, Hansen J. Havelund T, et al. Omeprazole 20 mg three days a week and 10 mg daily in prevention of duodenal ulcer relapse. Gastroenterology 100: 663-669, Mar 1991 .. "

_ IJ Ap,I991 INPHARMA- ISSN 0J56-270J/91/fUlJ-OOI6/0101.00/0 CAli;' l.tUlUlliolUll Ltll