Oat beta glucan for cosmetics and personal care

Sweden is famous for…

Biovelop: Company Introduction

� Biovelop AB is a producer of oat ingredients and an expert in cereal fractionation

� Patented technology platform for chemical-free production of healthy ingredients from cereal grains

� Focus areas: PromOat™ beta glucan for

3

� Focus areas: PromOat™ beta glucan for food, drinks and nutritional supplements, and Avenacare™ oat beta glucan for cosmetics and personal care products

� Production, Quality Control and R&D in Kimstad, Sweden

� Sales & Marketing in Stockholm, Sweden and London, England

� > €10m invested in full-scale production plant and pilot plant

The History of Oats

� Oats have a long history of usage in skin care thanks to their healing, soothing and anti-aging effects

� First usage dates back to 2000 BC in Egypt and the Arabian penisula ,where oats were used for treating skin conditions, such as eczema, burns and other inflammatory eruptions

Avena sativa – Latin for oats

� Famous authors from the Ancient period, including Pliny the Elder, Dioscorides and Hippocrates (the father of western medicine), all made reference to oats as a healing agent

� Vikings in Scandinavia used oat porridge on battle wounds in order to enhance the healing process

� Today oats are still a popular remedy for treating skin conditions in many countries, including Russia, Sweden, Scotland and France

Viking warriors used oats for wound healing

Hippocrates recommended oats for treating various skin

conditions

Biovelop AB

Avena sativa – Latin for oats

Biovelop AB, Kimstad HQ

High-quality, locally-sourced, Swedish oats

“Kerstin” oats

� Long tradition of oats in Sweden

� High-grade Swedish oats� Locally-grown� Close cooperation with

local farmers� Non-GMO� Sustainable

The Components of Oats

7

Food, Beverages, Nutraceuticals and Cosmetics

Sold as individual ingredients or blended and extruded for breakfast cereals, snacks and pet foods

Energy Production

Biovelop AB patented technology

Avenacare™ oat beta glucan

oat beta glucan:

� Naturally separated from the oat grain – no chemicals

� Supplied as a translucent solution with 1% oat beta glucan content

� {1,3}, {1,4} - β-D-Glucan

� GMO-free & Paraben-free� GMO-free & Paraben-free

� INCI: Beta Glucan or Beta Glucan (Oat)

� CAS number: 53238-80-5

� Gluten-free

� Hypoallergenic

Oat beta glucan: Molecular structure

Oat beta glucan with β1→4 and β1→3 linkages

70% (β1→4)-linked and 30% (β1→3)-linked β-D-glucopyranosyl residues, organised in blocks of (β1→4)-linkage sequences (cellotriosyl and cellotetraosyl cellulose-like segments) separated by single (β1→3)-linkages. Very different benefits and properties than {1,3}, {1,6} beta glucan found in mushrooms and yeast.

10

Avenacare™ oat beta glucan

How Avenacare™ differs from other beta glucans:

� Different chemical structures: {1,3}, {1,4} for oat beta glucan vs {1,3}, {1,6} for mushroom and yeast beta glucans

� Mushroom and yeast beta glucans are not water-soluble

� Oat beta glucan molecules are water-soluble

� Oat beta glucan molecules are able to penetrate the epidermis and the � Oat beta glucan molecules are able to penetrate the epidermis and the dermis

� Avenacare™ beta glucan is derived from oats and produced using a non-chemical process

� Different benefits for the skin: anti-aging, anti-irritation, rejuvenating and soothing vs immune system

� Avenacare™ moisturises for longer than mushroom beta glucan

� Avenacare™ benefits the hair and mouth, as well as the skin

The popularity of oatmeal continues to grow and grow…

12

enables that popularity to be extended into the cosmetics and personal care sectors

Avenacare™ - benefits in a diverse range of products

oat beta glucan has many benefits in:

� Skin care

� Hair care

� Personal care

Avenacare™ oat beta glucan

oat beta glucan – skin care benefits

Anti-aging

Visible improvement in lines and wrinkles

Elasticity and firmness of skin increased

Non-greasyNon-greasy

Anti-Irritant

Calms and soothes skin redness

Accelerates healing of wounds

Relieves sunburn, protects against UV light redness

Effective skin hydration

Avenacare™ oat beta glucan

Skin Care Applications

� Facial cream / lotion

� Eye cream / serum

� Body cream / lotion

� Hand cream / lotion� Hand cream / lotion

� Moisturizing cream / lotion

� Face mask

� Cleanser

� Pre-sun cream / lotion

� After-sun cream / lotion

� Lip balms

� Wound dressings

Clinical studies for Avenacare™ in skin care

� Irritation reduction

� Protection against exposure to sunlight

� Soothing the symptoms of sunlight exposure

� Anti-aging

Avenacare™ for appearance of redness reduction

� Avenacare™ reduces the appearance of skin irritation by 40% within 8 hours and by more than 50% within 24 hours

Avenacare™ helps prevent UV-induced redness

� Avenacare™ helps prevent the appearance of redness when applied prior to UV light exposure

� 44% less redness after 24 hours, 72% less after 48 hours

Avenacare™ reduces appearance of redness caused by UV light

� Avenacare™ reduces the appearance of redness caused by UV light when applied after UV exposure

� 30% less redness after 24 hours, 50% less after 48 hours

The anti-aging properties of oat beta glucan

� “A clinical study of 27 subjects was performed to evaluate the effects of beta-glucan on facial fine-lines and wrinkles. After 8 weeks of treatment, digital image analysis of silicone replicas indicated a significant reduction of wrinkle depth and height, and overall roughness.”

“The study supports the use of oat beta-glucan in the care and maintenance of healthy skin and the cosmetic treatment of the signs of aging”

International Journal of Cosmetic Science Vol.27 Page 292 –October 2005

Anti-aging mechanism of oat beta glucan

� Skin Care

� Penetrates skin to deepest levels of dermis

� Stimulates very mild auto-immune system response

� Collagen synthesis� Collagen synthesis

� Promotes cell renewal and anti-aging effect

� Seals, protects, and moisturizes skin

� Acts as a natural moisture barrier

� Can be used to transport other ingredients into the skin

Anti-aging mechanism of oat beta glucan

� Anti aging – Step by Step

1. Oat beta glucan penetrates the skin to the dermis

2. Oat beta glucan stimulates macrophages and fibroblasts

3. Interaction with macrophages induces production of Interleukin-1 (IL-1) which leads to production of Interleukin-1 (IL-1) which leads to production of procollagen by fibroblasts

4. The conversion of procollagen to collagen leads to the reduction of fine lines and wrinkles in the skin.

Glucan stimulates human dermal fibroblast collagen

biosynthesis through a nuclear factor-1 dependent mechanism, Wound Repair Regen. 10 (2002)

Avenacare™ oat beta glucan in hair care

� Avenacare™ in hair care products

� Improves tensile hair strength

� Reduces breakage� Reduces breakage

� Improves hair gloss

� Improves health of scalp

� Increases body and volume

� Forms natural moisture barrier

� Provides natural nourishment

� Non-irritating if eye contact occurs

Avenacare™ oat beta glucan in hair care

Leave-in Applications

� Conditioner

� Hair serum

Rinse-off Applications

� Shampoo

� Conditioner

Avenacare™ increases tensile hair strength

� Avenacare™ increases tensile hair strength by 21.68%

� 5% usage level in leave-on conditioning serum