Nucleotide Metabolism

nucleotide

nucleoside

a key molecule in purine and pyrimidine biosynthesis

fig 22-32

purines: where does all them darn atoms come from??

fig 22-33

fig 22-33

ETC.

fig 22-33, sorta

fig 22-33, still

inosine, built“on the ribose”to make IMP

fig 22-34

and inosinate begat adenylate and xanthylate, and xanthylatebegat guanylate…

fig 22-35

regulationof the early stepsof purinesynthesis

pyrimidinebiosynthesis

orotate, built“off the ribose”

fig 22-36

fig 22-36

pyrimidinebiosynthesis

OTP thenmodified toCTP, etc

fig 22-38

Two ways for mammals to make and/or use purines and pyrimidines

1) de novo synthesis (see above)

2) salvage pathways

Ad + PRPP AMP + PP

Two ways for mammals to make and/or use purines and pyrimidines

1) de novo synthesis (see above)

2) salvage pathways

hypoxanthine + PRPP IMP + PP

Lesch-Nyhan disease

Two ways for mammals to make and/or use purines and pyrimidines

1) de novo synthesis (see above)

2) salvage pathways

pyrimidine salvage is similar but not wellunderstood in mammals…

fig 22-48

inhibitors of glutamineamindo-transferases

chemo-therapeutics

fig 22-39

rememberthe “D” inDNA???

either or

what’s thedifference between T and U??

fig 22-44

where theTHF getsits methy...

fig 22-44

more chemotherapeutics

fig 22-49

inhibitors of dihydrofolate reductase cycle

catabolism ofpurines…

fig 22-45

xanthineoxidase

fig 22-45

out with gout!!!

1735

fig 22-47

out with gout!!!

xanthine oxidase too active

fig 22-47

out with gout!!!

xanthine oxidase inhibitor