Novocure (NVCR) overview3sj0u94bgxp33grbz1fkt62h-wpengine.netdna-ssl.com/wp...As of the date of this presentation, Optune is only FDA-approved for the treatment of adults with supratentorial

Novocure (NVCR) overview updated July 2018

© Novocure 2018 2

forward-looking statements

This presentation contains certain forward-looking statements with respect to the business of Novocure and certain of its plans and objectives, including with respect

to the development and commercialization of its lead product candidate, Optune, for a number of oncology indications. These forward-looking statements can be

identified in this presentation by the fact that they do not relate only to historical or current facts. Forward-looking statements often use words “expect”, “intend”,

“anticipate”, “plan”, “may”, “should”, “would”, “could” or other words of similar meaning. These statements are based on assumptions and assessments made by

Novocure in light of industry experience and perception of historical trends, current conditions, expected future developments and other appropriate factors. By their

nature, forward-looking statements involve risk and uncertainty, and Novocure's performance and financial results could differ materially from those expressed or

implied in these forward-looking statements due to general financial, economic, regulatory and political conditions as well as more specific risks and uncertainties

facing Novocure such as those set forth in its Annual Report on Form 10-K filed on February 22, 2018, or in subsequent quarterly filings with the U.S. Securities and

Exchange Commission. Should one or more of these risks or uncertainties materialize, or should underlying assumptions prove incorrect, actual results may vary

materially from those described in this presentation. Novocure assumes no obligation to update or correct the information contained in this presentation, whether as

a result of new information, future events or otherwise, except to the extent legally required.

The statements contained in this presentation are made as at the date of this presentation, unless some other time is specified in relation to them, and service of this

presentation shall not give rise to any implication that there has been no change in the facts set out in this presentation since such date. Nothing contained in this

presentation shall be deemed to be a forecast, projection or estimate of the future financial performance of Novocure, except where expressly stated.

As of the date of this presentation, Optune is only FDA-approved for the treatment of adults with supratentorial glioblastoma, or GBM, and its approval for other

indications is not certain. Novocure can provide no assurances regarding market acceptance of Optune or its successful commercialization, and can provide no

assurances regarding the company’s results of operations or financial condition in the future. This presentation is for informational purposes only and may not be

relied upon in connection with the purchase or sale of any security.

© Novocure 2018 3

INDICATIONS

• Optune is intended as a treatment for adult patients (22 years of age or older) with histologically-confirmed glioblastoma multiforme

(GBM).

• Optune with temozolomide is indicated for the treatment of adult patients with newly diagnosed, supratentorial glioblastoma following

maximal debulking surgery, and completion of radiation therapy together with concomitant standard of care chemotherapy.

• For the treatment of recurrent GBM, Optune is indicated following histologically-or radiologically-confirmed recurrence in the

supratentorial region of the brain after receiving chemotherapy. The device is intended to be used as a monotherapy, and is intended as an

alternative to standard medical therapy for GBM after surgical and radiation options have been exhausted.

CONTRAINDICATIONS

• Do not use Optune in patients with an active implanted medical device, a skull defect (such as, missing bone with no replacement), or

bullet fragments. Use of Optune together with implanted electronic devices has not been tested and may theoretically lead to

malfunctioning of the implanted device. Use of Optune together with skull defects or bullet fragments has not been tested and may

possibly lead to tissue damage or render Optune ineffective.

• Do not use Optune in patients that are known to be sensitive to conductive hydrogels. In this case, skin contact with the gel used with

Optune may commonly cause increased redness and itching, and rarely may even lead to severe allergic reactions such as shock and

respiratory failure.

Optune® indications for use and important safety information

© Novocure 2018 4

WARNINGS AND PRECAUTIONS

• Optune can only be prescribed by a healthcare provider that has completed the required certification training provided by Novocure (the

device manufacturer).

• Do not prescribe Optune for patients that are pregnant, you think might be pregnant or are trying to get pregnant, as the safety and

effectiveness of Optune in these populations have not been established.

• The most common (≥10%) adverse events involving Optune in combination with temozolomide were thrombocytopenia, nausea,

constipation, vomiting, fatigue, medical device site reaction, headache, convulsions, and depression.

• The most common (≥10%) adverse events seen with Optune monotherapy were medical device site reaction and headache.

• The following adverse reactions were considered related to Optune when used as monotherapy: medical device site reaction, headache,

malaise, muscle twitching, fall and skin ulcer.

• Use of Optune in patients with an inactive implanted medical device in the brain has not been studied for safety and effectiveness, and use

of Optune in these patients could lead to tissue damage or lower the chance of Optune being effective.

• If the patient has an underlying serious skin condition on the scalp, evaluate whether this may prevent or temporarily interfere with Optune

treatment.

Optune® indications for use and important safety information

© Novocure 2018 5

a global oncology company with a proprietary platform GROWING COMMERCIAL BUSINESS SIGNIFICANT UPSIDE POTENTIAL

• More than 2,100 patients on therapy • 14 consecutive quarters of patient growth • $217 million trailing twelve month revenues

• Increase adoption and average reimbursement in GBM

• Advance clinical pipeline in five additional solid tumor indications

Information above as of June 30, 2018

© Novocure 2018 6

we can leverage physics to fight cancer

AN ELECTRIC FIELD EXERTS FORCES ON CHARGED OBJECTS

TUMOR TREATING FIELDS USES ELECTRIC FIELDS TO DISRUPT CELL DIVISION

+ + + + + + + + + + + + + + +

- - - - - - - - - - - - - - -

+ +

- MISALIGNED

TUBULINS INTERFERE WITH FORMATION OF

MITOTIC SPINDLE

MISALIGNED SEPTINS

INTERFERE WITH FORMATION OF

CONTRACTILE RING

ALTERNATING ELECTRIC FIELDS DISRUPT CANCER

CELL DIVISION

CANCER CELL DEATH

TUMOR TREATING FIELDS DESCRIBES ELECTRIC FIELDS THAT ALTERNATE 100,000 TO 300,000 TIMES PER SECOND TO TARGET CANCER CELLS

© Novocure 2018 7

broad applicability to solid tumors INDICATIONS IN-VITRO EVIDENCE IN-VIVO EVIDENCE FIRST IN HUMAN EVIDENCE

Glioblastoma

Malignant melanoma

Non-small cell lung cancer

Pancreatic cancer

Breast cancer

Mesothelioma

Ovarian carcinoma

Renal adenocarcinoma

Cervical cancer

Colorectal carcinoma

Ependymoma

Gastric adenocarcinoma

Gliosarcoma

Hepatocellular carcinoma

Medulloblastoma

Meningioma

Small cell lung cancer

Urinary transitional cell carcinoma

© Novocure 2018 8

proven superior long-term survival with Optune® plus temozolomide in GBM1

Median OS from randomization (months)

20.9 16.0

Stratified log-rank p=0.00006

HR (95% CI) 0.63 (0.53-0.76)

Median OS from diagnosis (months)

24.5 19.8 24.5

20.9 16.0

19.8

Optune® + TMZ (n=466) TMZ alone (n=229)

0 6 12 48 54 60 18 24 30 36 42

0.8

0.7

0.6

0.5

0.4

0.3

0.2

0.1

0.0

0.9

1.0

Pro

bab

ility

of

surv

ival

Overall Survival (months)

Intent-to-treat population1

43%

13% 31%

5%

TMZ alone

TMZ alone

Optune® + TMZ

Optune® + TMZ

p=0.001

p=0.0037

1. Stupp R, Taillibert S, Kanner A, et al. Effect of Tumor-Treating Fields Plus Maintenance Temozolomide vs Maintenance Temozolomide Alone on Survival in Patients With Glioblastoma: A Randomized Clinical Trial. JAMA. 2017;318(23):2306–2316.

© Novocure 2018 9

Optune® plus temozolomide consistently sustained superior rates of survival1

73%

43%

26% 20%

13%

65%

31%

16% 8% 5% 0%

10%

20%

30%

40%

50%

60%

70%

80%

90%

100%

1 2 3 4 5

Surv

ival

rat

e (%

)

Year from randomization

Optune® + TMZ (n=466)

TMZ alone (n=229)

1. Stupp R, Taillibert S, Kanner A, et al. Effect of Tumor-Treating Fields Plus Maintenance Temozolomide vs Maintenance Temozolomide Alone on Survival in Patients With Glioblastoma: A Randomized Clinical Trial. JAMA. 2017;318(23):2306–2316.

FIVE-YEAR SURVIVAL INTENT-TO-TREAT ANALYSIS

p=0.029

p=0.001

p=0.004 p=0.0002

p=0.004

© Novocure 2018 10

patients with increased compliance had increased survival benefit1

• A trend in favor of longer overall

survival was seen with higher

compliance

• A threshold value of 50% average

monthly compliance with Tumor

Treating Fields was needed to show an

extension of overall survival (HR 0.67,

95% CI 0.45–0.99) compared to

temozolomide alone

• Both progression-free survival and

overall survival were extended with

increased compliance beyond 50% 1. Ram Z, Kim CY, Nicholas GA and Toms S on behalf of EF-14 investigators. Compliance and treatment duration predict survival in a phase 3 EF-14 trial of Tumor Treating Fields with temozolomide in patients with newly diagnosed

glioblastoma. Presented at: 2017 Society for Neuro Oncology; November 16-19, 2017; San Francisco, CA. Oral presentation ACTR-27.

© Novocure 2018 11

five-year survival analysis in most compliant patients (>90%)1

86%

55%

29% 29% 29%

65%

31%

16%

8% 5% 0%

10%

20%

30%

40%

50%

60%

70%

80%

90%

100%

1 2 3 4 5

Surv

ival

rat

e (%

)

Year from randomization

Optune > 90% compliance + temozolomide (n=43)

temozolomide alone (n=229)

1. Ram Z, Kim CY, Nicholas GA and Toms S on behalf of EF-14 investigators. Compliance and treatment duration predict survival in a phase 3 EF-14 trial of Tumor Treating Fields with temozolomide in patients with newly diagnosed glioblastoma. Presented at: 2017 Society for Neuro Oncology; November 16-19, 2017; San Francisco, CA. Oral presentation ACTR-27.

© Novocure 2018 12

The updated NCCN Clinical Practice Guidelines in

Oncology (NCCN Guidelines®) for Central Nervous

System Cancers now include alternating electric field

therapy (Optune) in combination with temozolomide

(TMZ) following maximal safe resection and standard

brain radiation therapy with concurrent TMZ as

Category 1 recommended treatment option for

patients with newly diagnosed supratentorial

glioblastoma (GBM) and good performance status.*

There is uniform NCCN consensus for this

recommendation based on high-level evidence

(Category 1).

NCCN guidelines updated in March 2018

* The NCCN defines good performance as Karnofsky Performance Score (KPS) ≥60. The trial for which the IFU is based used an eligibility criteria of KPS ≥70.

© Novocure 2018 13

global commercial presence ADULT PATIENTS WITH RECURRENT AND NEWLY DIAGNOSED GBM

JAPAN

4 sales force colleagues

UNITED STATES


JAPAN

174 certified centers

EMEA


UNITED STATES


certified centers

sales force colleagues

EMEA


global active markets as of June 30, 2018

© Novocure 2018 14

steady prescription growth in newly diagnosed GBM

KEY TAKEAWAYS

• ~75% of Q2 prescriptions were

written for patients with newly

diagnosed GBM

• We believe growth is a sign of

increasing physician

confidence and belief

0

100

200

300

400

500

600

700

800

900

1000

Q3 2016 Q4 2016 Q1 2017 Q2 2017 Q3 2017 Q4 2017 Q1 2018 Q2 2018

Prescriptions for newly diagnosed GBM

~50% of total

~65% of total

~75% of total

© Novocure 2018 15

continued growth in active patients active patients at period end

14 CONSECUTIVE QUARTERS OF ACTIVE PATIENT GROWTH SINCE INITIAL PRESENTATION OF EF-14 DATA

8,000+ PATIENTS TREATED TO DATE GLOBALLY

0

500

1000

1500

2000

2500

Q1 2015 Q2 2015 Q3 2015 Q4 2015 Q1 2016 Q2 2016 Q3 2016 Q4 2016 Q1 2017 Q2 2017 Q3 2017 Q4 2017 Q1 2018 Q2 2018

U.S. active patients EMEA active patients

372 425 469 605

797 891

985 1,091

1,266

1,460

1,683 1,834

2,009

Japan active patients

2,169

© Novocure 2018 16

advancing clinical pipeline

PRECLINICAL PHASE II

PILOT PHASE III PIVOTAL MILESTONES

Brain metastases METIS trial last patient in 2019 with final data collection in 2020

Non-small cell lung cancer LUNAR trial last patient in 2019 with final data collection in 2021

Pancreatic cancer PANOVA 3 trial last patient in 2020 with final data collection in 2022

Ovarian cancer phase three pivotal trial open in 2H 2018

Mesothelioma STELLAR trial data presentation in 2H 2018

Liver cancer HEPANOVA trial first patient in 2H 2018

Trial complete Trial ongoing

© Novocure 2018 17

$0

$10,000

$20,000

$30,000

$40,000

$50,000

$60,000

$70,000

Q1 2015 Q2 2015 Q3 2015 Q4 2015 Q1 2016 Q2 2016 Q3 2016 Q4 2016 Q1 2017 Q2 2017 Q3 2017 Q4 2017 Q1 2018 Q2 2018

demonstrated financial performance

EMEA net revenues Japan net revenues

global net revenues (USD in thousands)

$5,208 $6,543 $8,953

$12,383 $13,053

$17,919 $21,674

$30,242

U.S. net revenues

$34,880 $38,376

$50,109 60% Q2 2018 VERSUS Q2 2017 YEAR-OVER-YEAR REVENUE GROWTH

$219 MILLION IN CASH AND SHORT-TERM EQUIVALENTS AS OF JUNE 30, 2018

$33,087 $82,888

FY 2015 FY 2016

$177,026

FY 2017

$53,661 $52,125

$61,514

© Novocure 2018 18

q2 2018 selected financial highlights

U.S. DOLLARS IN THOUSANDS

Q2 2018 Q2 2017 %

CHANGE Q2 2018

YTD Q2 2017

YTD %

CHANGE

Net revenues $ 61,514 $ 38,376 60% $ 113,639 $ 73,256 55% Cost of revenues 19,833 13,152 51% 38,071 24,816 53%

Gross profit 41,681 25,224 65% 75,568 48,440 56%

Research, development and clinical trials 11,362 9,371 21% 22,466 18,782 20% Sales and marketing 19,196 16,360 17% 37,331 31,116 20% General and administrative 18,208 15,023 21% 35,533 27,445 29% Total operating costs and expenses 48,766 40,754 20% 95,330 77,343 23%

Operating income (loss) (7,085 ) (15,530 ) 54% (19,762 ) (28,903 ) 32% Financial expenses, net 2,860 2,183 31% 7,713 4,629 67%

Income (loss) before income taxes (9,945 ) (17,713 ) 44% (27,475 ) (33,532 ) 18% Income taxes 5,565 3,461 61% 8,759 5,687 54%

Net income (loss) $ (15,510 ) $ (21,174 ) 27% $ (36,234 ) $ (39,219 ) 8%

Cash and cash equivalents $ 114,456 $ 80,190 $ 114,456 $ 80,190 Short-term investments 104,499 104,186 104,499 104,186

© Novocure 2018 19

long term value creation beyond 2018

• Launch Tumor Treating Fields platform for additional indications in

large addressable markets

o Brain metastases from non-small cell lung cancer

o Non-small cell lung cancer

o Pancreatic cancer

o Ovarian cancer

• Drive commercial adoption of Optune within GBM

• Expand coverage for GBM patients in currently active markets and

establish access for GBM patients in new markets

• Progress mesothelioma towards commercialization

• Advance the clinical pipeline in multiple solid tumor indications

• Grow annual revenues while improving SG&A operating leverage

near-term opportunity

2018- 2021

long-term opportunity

2021+

commercial appendix

© Novocure 2018 21

direct-to-patient distribution model*

PHYSICIAN SENDS

PRESCRIPTION

ORDER TO

NOVOCURE

PHYSICIAN OR

NOVOCURE USES

NOVOTAL SYSTEM TO

CREATE ARRAY

PLACEMENT MAP

NOVOCURE

DELIVERS OPTUNE

AND TRAINS

PATIENT/FAMILY

NOVOCURE

PROVIDES 24/7

TECH SUPPORT AND

SUPPLIES

TRANSDUCER

ARRAYS

NOVOCURE BILLS

THIRD-PARTY

PAYER AND

PATIENT1 FOR EACH

MONTH OF

THERAPY

PHYSICIAN SEES

PATIENT FOR

REGULAR

COMPLIANCE

MONITORING AND

FOLLOW-UP

APPOINTMENTS

NOVOCURE

* Novocure distributes product through hospitals in Japan. 1. Subject to patient assistance programs.

© Novocure 2018 22

established U.S. commercial market access

>217 MILLION COVERED LIVES

IN THE U.S. AS OF MARCH 31, 2018

>187 MILLION CONTRACTED LIVES IN THE U.S. AS OF

MARCH 31, 2018

1. U.S. population insured with employers, non-group insurance or Medicare Advantage plans

2. Appealing Medicare fee-for-service denials, impacting 20-25% of U.S. active patients

96%

OF AMERICANS WITH PRIVATE HEALTH INSURANCE1,2

NOW HAVE POSITIVE COVERAGE OF OPTUNE

© Novocure 2018 23

expanding global commercial market access

MARKET STATUS REIMBURSEMENT STATUS GBM MARKET SIZE

ESTIMATION

POSITIVE NATIONAL REIMBURSEMENT DECISIONS

Japan Commercial launch in Q1 2018

National reimbursement contract signed in Q4 2017 1,500 annual cases diagnosed

Austria Commercial launch in Q4 2017

National reimbursement contract signed in Q3 2017 340 annual cases diagnosed

ONGOING DIALOGUES WITH GOVERNMENT PAYERS IN THE UNITED STATES, GERMANY, SWITZERLAND AND ISRAEL

United States No material payments from Medicare to date

In active discussions with CMS administration 12,500 annual cases diagnosed

Germany Receive reimbursement on case-by-case basis

Pathway for national reimbursement established Q3 2017 via G-BA budgeted clinical trial (expected to begin 2H 2018)

3,600 annual cases diagnosed

Switzerland Single-payer system Pursuing national reimbursement 330 annual cases diagnosed

Israel No material payments to date

Pursuing national reimbursement 325 annual cases diagnosed

clinical appendix

© Novocure 2018 25

evolving treatment paradigms for solid tumor cancers

radiation pharmacological treatments

tumor treating fields (TTFields)

• Reduces size of a tumor prior to initiation of additional therapies

• Invasive to patient

• Unable to kill microscopic disease

• Kills cells when delivered at high doses

• Injures healthy tissues as well as cancer cells

• Numerous potentially toxic side effects

• Includes chemotherapy, targeted therapies and immuno-oncology

• Many treatments target specific patient subgroups

• Frequently accompanied by numerous side effects

• Electric fields tuned to specific frequencies

• Disrupts solid tumor cancer cell division

• Mild side effect profile with no known cumulative toxicity

USED ALONE OR IN COMBINATION TO TREAT SOLID TUMORS

surgery

© Novocure 2018 26

TTFields are frequency-tuned to cell size to maximize effects on mitosis

Normal Intestine

~50 kHz

Pancreatic Cancer

150 kHz

NSCLC

150 kHz

Ovarian Cancer

200 kHz

GBM

200 kHz

EFFECTS ON CELLS ARE FREQUENCY SPECIFIC AND INVERSELY RELATED TO CELL SIZE

© Novocure 2018 27

transducer array placement

abdominal array placement

torso array placement

pelvic array placement

© Novocure 2018 28

addressing large market segments with significant unmet medical needs

BRAIN METASTASES

NON-SMALL CELL LUNG CANCER

PANCREATIC CANCER

OVARIAN CANCER MESOTHELIOMA

223,000 CASES DIAGNOSED

ANNUALLY IN TARGET MARKETS3-5

8% FIVE YEAR SURVIVAL3








ANNUALLY IN TARGET MARKETS3,6-7



ANNUALLY IN TARGET MARKETS1

~25% OF NSCLC PATIENTS DEVELOP BRAIN METS2

1. Goetz P, Ebinu JO, Roberge D, Zadeh G. Current Standards in the Management of Cerebral Metastases. Intl J of Surg Onc. 2012;2012:493426. doi:10.1155/2012/493426. 2. Owen S, Souhami L. The management of brain metastases in non-small cell lung cancer. Frontiers in Oncology. 2014;4:248. doi:10.3389/fonc.2014.00248. 3. Howlader N, Noone AM, et al. SEER Cancer Statistics Review, 1975-2014, National Cancer Institute. Bethesda, MD, https://seer.cancer.gov/csr/1975_2014/, based on November 2016 SEER data submission, posted to SEER web site, April 2017. 4. Ferlay J, Steliarova-Foucher E, et al. Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012. Eur J Cancer. 2013;49(6):1374-403. doi: 10.1016/j.ejca.2012.12.027. 5. WHO (2016) GLOBOCAN 2012: Estimated Cancer Incidence, Mortality, and Prevalence Worldwide in 2012, Lyon, France (accessed January 2018). 6. Peto J, Decarli A, La Vecchia C, Levi F, Negri E. The European mesothelioma epidemic. Br J Cancer 1999;79:666 –72. doi: 10.1038/sj.bjc.6690105. 7. Robinson B.M. Malignant pleural mesothelioma: an epidemiological perspective. Ann Cardiothorac Surg. 2012; 1(4): 491–496. doi: 10.3978/j.issn.2225-319X.2012.11.04.

© Novocure 2018 29

phase 2 pilot STELLAR trial FIRST LINE TREATMENT OF MALIGNANT PLEURAL MESOTHELIOMA

A prospective, open label, single-arm, non-randomized, multicenter study testing safety and preliminary efficacy of

TTFields at 150 kHz in combination with pemetrexed and cisplatin or carboplatin in patients with previously untreated

malignant pleural mesothelioma versus historical controls

• 80 patients in Europe with unresectable, previously untreated malignant mesothelioma

• Last patient enrolled March 2017 with twelve month follow-up

• Endpoints:

o Primary endpoint — overall survival (OS)

o Secondary endpoints — progression free survival (PFS), response rate, treatment-emergent toxicity

Novocure, Ltd. Safety and Efficacy of TTFields (150 kHz) Concomitant With Pemetrexed and Cisplatin or Carboplatin in Malignant Pleural Mesothelioma (STELLAR) In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). 2000-[cited 2018 May]. Available from: https://clinicaltrials.gov/ct2/show/NCT02397928. NLM Identifier: NCT02397928

© Novocure 2018 30

phase 2 pilot STELLAR trial interim results

• Interim data for the first 42 patients, with average follow-up of 11.5 months, presented at IASLC 2016

• Final top-line results, announced April 2018, exceeded interim analysis for all efficacy endpoints

o Anticipate presentation of final results at a medical conference in 2H 2018

o Plan to submit Humanitarian Device Exemption application to the FDA in 2H 2018

FIRST LINE TREATMENT OF MALIGNANT PLEURAL MESOTHELIOMA

Novocure, Ltd. Safety and Efficacy of TTFields (150 kHz) Concomitant With Pemetrexed and Cisplatin or Carboplatin in Malignant Pleural Mesothelioma (STELLAR) In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). 2000-[cited 2018 May]. Available from: https://clinicaltrials.gov/ct2/show/NCT02397928. NLM Identifier: NCT02397928 1. Cerasoli, G.L. International Association for the Study of Lung Cancer. OA22.01 – STELLAR – Interim Results of a Phase 2 Trial of TTFields with Chemotherapy for First Line Treatment of Malignant Mesothelioma. Oral Session: Novel

Trials and Biomarkers in Malignant Pleural Mesothelioma. Wednesday, Dec. 7, 2016, 2:20 p.m. CET 2. Vogelzang N.J., Rusthoven J.J., Symanowski J., et al. Phase III Study of Pemetrexed in Combination With Cisplatin Versus Cisplatin Alone in Patients With Malignant Pleural Mesothelioma J Clin Oncol. 2003 Jul 15;21(14):2636–44. doi:

10.1200/JCO.2003.11.136

EFFICACY ENDPOINTS

TTFIELDS WITH PEMETREXED AND

CISPLATIN OR CARBOPLATIN1

PEMETREXED AND CISPLATIN-ALONE

HISTORICAL RESULTS2

Median PFS 7.3 months 5.7 months

Median OS Not yet reached 12.1 months

One-year survival rate 79.7% 50.3%

© Novocure 2018 31

phase 2 pilot STELLAR trial interim results

FIRST LINE TREATMENT OF MALIGNANT PLEURAL MESOTHELIOMA

PROGRESSION-FREE SURVIVAL (N=42)1 OVERALL SURVIVAL (N=42) 1

Novocure, Ltd. Safety and Efficacy of TTFields (150 kHz) Concomitant With Pemetrexed and Cisplatin or Carboplatin in Malignant Pleural Mesothelioma (STELLAR) In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). 2000-[cited 2018 May]. Available from: https://clinicaltrials.gov/ct2/show/NCT02397928. NLM Identifier: NCT02397928 1. Cerasoli, G.L. International Association for the Study of Lung Cancer. OA22.01 – STELLAR – Interim Results of a Phase 2 Trial of TTFields with Chemotherapy for First Line Treatment of Malignant Mesothelioma. Oral Session: Novel

Trials and Biomarkers in Malignant Pleural Mesothelioma. Wednesday, Dec. 7, 2016, 2:20 p.m. CET

© Novocure 2018 32

METIS phase 3 pivotal trial initiated in 2016 BRAIN METASTASES FROM NON-SMALL CELL LUNG CANCER

A prospective, randomized controlled, multicenter trial testing efficacy, safety and neurocognitive outcomes of TTFields at 150 kHz following stereotactic radiosurgery for 1-10 brain metastases from non-small cell lung cancer

• 270 patients internationally, randomized 1:1 (TTFields vs supportive care) • Last patient enrollment expected in 2019, twelve month follow-up after final patient enrollment • Primary endpoint — time to first intracranial progression • Secondary endpoints include neurocognitive failure, overall survival, radiological response rate

Novocure, Ltd. Effect of TTFields (150 kHz) in Non-small Cell Lung Cancer (NSCLC) Patients With 1-10 Brain Metastases Following Radiosurgery (METIS) In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). 2000-[cited 2018 May]. Available from: https://clinicaltrials.gov/ct2/show/NCT02831959. NLM Identifier: NCT02831959

screening and baseline evaluation

ran

do

miz

atio

n 1

:1

stereotactic radiosurgery ttfields MRI q2m until progression

stereotactic radiosurgery supportive care MRI q2m until progression

© Novocure 2018 33

phase 2 pilot EF-15 trial SECOND LINE TREATMENT FOR ADVANCED NON-SMALL CELL LUNG CANCER

A prospective, open label, single-arm, non-randomized, multicenter study testing safety and preliminary efficacy of TTFields at 150 kHz in combination with pemetrexed in pretreated patients with locally advanced and/or metastatic non-small cell lung cancer versus historical controls

• 42 patients in Switzerland with locally advanced and/or metastatic non-small cell lung cancer • Last patient enrolled May 2011 with six month follow-up, data published in Lung Cancer in 2013

Novocure, Ltd. NovoTTF-100L in Combination With Pemetrexed (Alimta®) for Advanced Non-small Cell Lung Cancer In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). 2000-[cited 2018 May]. Available from: https://clinicaltrials.gov/ct2/show/NCT00749346. NLM Identifier: NCT00749346 1. Pless M., Droege C., von Moos R., et al. A phase I/II trial of Tumor Treating Fields (TTFields) therapy in combination with pemetrexed for advanced non-small cell lung cancer. Lung Cancer. 2013 Sep;81(3):445-50. doi:

10.1016/j.lungcan.2013.06.025 2. Hanna N., Shepherd F.A., Fossella F.V., et al. Randomized Phase III Trial of Pemetrexed Versus Docetaxel in Patients With Non–Small-Cell Lung Cancer Previously Treated With Chemotherapy. J Clin Oncol. 2004 May 1;22(9):1589-97.

doi: 10.1200/JCO.2004.08.163

EFFICACY ENDPOINTS

TTFIELDS WITH PEMETREXED1

PEMETREXED-ALONE HISTORICAL RESULTS2

Median in-field PFS 6.5 months n/a

Median PFS 5 months 2.9 months

Median OS 13.8 months 8.3 months

One-year survival rate 57% 29.7%

© Novocure 2018 34

A prospective, randomized controlled, multicenter trial testing efficacy and safety of TTFields at 150 kHz in combination with docetaxel or immune checkpoint inhibitors for stage IV NSCLC patients following progression while on or after platinum based treatment

• 534 patients (TTFields plus docetaxel or immune checkpoint inhibitors vs docetaxel or immune checkpoint inhibitors alone) • Last patient enrollment expected in 2019, eighteen month follow-up after final patient enrollment • Primary endpoint – overall survival (OS) (superiority) • Secondary endpoints –

o OS of TTFields + docetaxel vs docetaxel alone (superiority) o OS of TTFields + immune checkpoint inhibitors vs immune checkpoint inhibitors alone (superiority) o OS of TTFields + docetaxel vs immune checkpoint inhibitors alone (non-inferiority)

LUNAR phase 3 pivotal trial initiated in 2017 SECOND LINE TREATMENT FOR ADVANCED NON-SMALL CELL LUNG CANCER

Novocure, Ltd. Effect of Tumor Treating Fields (TTFields) (150 kHz) as Second Line Treatment of Non-small Cell Lung Cancer (NSCLC) in Combination With PD-1 Inhibitors or Docetaxel (LUNAR) In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). 2000-[cited 2018 May]. Available from: https://clinicaltrials.gov/ct2/show/NCT02973789. NLM Identifier: NCT02973789

progression on or after platinum-based therapy

screening and baseline

evaluation

ran

do

miz

atio

n

1:1

ttfields + immune checkpoint

inhibitor/docetaxel

CT q6w until progression

three post-progression

follow-up visits

survival follow up

immune checkpoint inhibitor/docetaxel


three post-progression

follow-up visits

survival follow up

© Novocure 2018 35

phase 2 pilot PANOVA trial LOCALLY ADVANCED AND METASTATIC PANCREATIC CANCER

A prospective, open label, single-arm, non-randomized, multicenter study testing feasibility, safety and preliminary efficacy of TTFields at 150 kHz in combination with gemcitabine or gemcitabine plus nab-paclitaxel in patients with advanced pancreatic cancer versus historical controls

• 40 patients (2 cohorts of 20 patients) in Europe with advanced pancreatic cancer • Last patient enrolled May 2016 with six month follow-up

Novocure, Ltd. Safety Feasibility and Effect of TTFields (150 kHz) Concomitant With Gemcitabine or Concomitant With Gemcitabine Plus Nab-paclitaxel for Front-line Therapy of Advanced Pancreatic Adenocarcinoma (PANOVA) In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). 2000-[cited 2018 May]. Available from: https://clinicaltrials.gov/ct2/show/NCT01971281. NLM Identifier: NCT01971281 1. Rivera F., et al. PANOVA: A pilot study of TTFields concomitant with gemcitabine for front-line therapy of advanced pancreatic adenocarcinoma. In: 2016 Gastrointestinal Cancers Symposium; 2016 Jan 21-23; San Francisco, CA. Alexandria (VA): ASCO; 2016. Abstract 682. 2. Von Hoff D.D., Ervin T., Arena F.P., et al. Increased Survival in Pancreatic Cancer with nab-Paclitaxel plus Gemcitabine. N Engl J Med. 2013 Oct 31;369(18):1691-703. doi: 10.1056/NEJMoa1304369 3. Benavides M. et.al. PANOVA: A phase II study of TTFields (150kHz) concomitant with standard chemotherapy for front line therapy of advanced pancreatic adenocarcinoma In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2017 Apr

1-5; Washington, DC. Philadelphia (PA): AACR; 2017. Abstract CT130.

EFFICACY ENDPOINTS

TTFIELDS WITH GEMCITABINE1

GEMCITABINE-ALONE HISTORICAL RESULTS2

TTFIELDS WITH NAB-PACLITAXEL + GEMCITABINE3

NAB-PACLITAXEL + GEMCITABINE

HISTORICAL RESULTS2

Median PFS 8.3 months 3.7 months 12.7 months 5.5 months

Median OS 14.9 months 6.7 months Not yet reached 8.5 months

One-year survival rate 55% 22% 72% 35%

Partial response rate 30% 7% 40% 23%

Stable disease 30% 28% 47% 27%

© Novocure 2018 36

PANOVA 3 pivotal trial initiated in 2017 LOCALLY ADVANCED PANCREATIC CANCER

A prospective, randomized controlled, multicenter trial testing efficacy and safety of TTFields at 150 kHz in combination with nab-paclitaxel plus gemcitabine as first-line treatment in patients with unresectable, locally advanced pancreatic cancer

• 556 patients internationally, randomized 1:1 (TTFields plus nab-paclitaxel plus gemcitabine vs nab-paclitaxel plus gemcitabine alone)

• Last patient enrollment expected in 2020, eighteen month follow-up after final patient enrollment • Primary endpoint – overall survival (OS) • Secondary endpoints include PFS, objective response rate, rate of resectability, quality of life

screening and baseline evaluation

ran

do

miz

atio

n 1

:1

ttfields + nab-paclitaxel + gemcitabine


second line chemotherapy survival follow up

nab-paclitaxel + gemcitabine


second line chemotherapy survival follow up

Novocure, Ltd. Effect of Tumor Treating Fields (TTFields, 150 kHz) as Front-Line Treatment of Locally-advanced Pancreatic Adenocarcinoma Concomitant With Gemcitabine and Nab-paclitaxel (PANOVA-3) In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). 2000-[cited 2018 May]. Available from: https://clinicaltrials.gov/ct2/show/NCT03377491. NLM Identifier: NCT03377491

© Novocure 2018 37

phase 2 pilot INNOVATE trial RECURRENT OVARIAN CANCER

A prospective, open label, single-arm, non-randomized, multicenter study testing feasibility, safety, toxicity and preliminary efficacy of TTFields at 200 kHz in combination with weekly paclitaxel in patients with recurrent ovarian cancer versus historical controls

• 30 patients in Europe with recurrent ovarian cancer • Last patient enrolled May 2016 with six month follow-up

Novocure, Ltd. Safety, Feasibility and Effect of TTFields (200 kHz) Concomitant With Weekly Paclitaxel in Recurrent Ovarian Carcinoma (INNOVATE) In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). 2000-[cited 2018 May]. Available from: https://clinicaltrials.gov/ct2/show/NCT02244502. NLM Identifier: NCT02244502 1. Vergote I., et.al. INNOVATE: a phase II study of TTFields (200 kHz) concomitant with weekly paclitaxel for recurrent ovarian carcinoma. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research;

2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; 2017. Abstract CT135. 2. Poveda A.M., Selle F., Hiplert F. et al. Bevacizumab Combined With Weekly Paclitaxel, Pegylated Liposomal Doxorubicin, or Topotecan in Platinum-Resistant Recurrent Ovarian Cancer: Analysis by Chemotherapy Cohort of the

Randomized Phase III AURELIA Trial. J of Clin Onc. 2015 Nov 10;33(32):3836-8. doi: 10.1200/JCO.2015.63.1408. * Median PFS reflects the weekly paclitaxel subgroup; Median PFS for all chemotherapies was 3.4 months

EFFICACY ENDPOINTS

TTFIELDS WITH PACLITAXEL1

PACLITAXEL-ALONE HISTORICAL RESULTS2

Median PFS 8.9 months 3.9 months*

Median OS Not yet reached 13.2 months

One-year survival rate 61%

Documents

Novocure (NVCR) overview3sj0u94bgxp33grbz1fkt62h-wpengine.netdna-ssl.com/wp...As of the date of this presentation, Optune is only FDA-approved for the treatment of adults with supratentorial