Non-Invasive Measurement of Your

Antioxidant Defense System Presented by Joe Chang, Ph.D.

President, Pharmanex

This material has been prepared by Pharmanex to be used in conjunction with general educational events and activities only. Alterations or modifications of this presentation without the express approval of Pharmanex is prohibited.

The Antioxidant Network

Synergy:If one member is weak, the entire antioxidant

network is weak

Problems with current technology

• Requires body fluids

• Take 14-21 days

• Cost $25.00 to $300.00 per test

• Complicated

LifePak $200,000 Clinical StudyFASEB Journal 1999 Vol.13(4): A546

(means +/- SD)

70.667.4

94.3

68.1

0

20

40

60

80

100

120

140

Baseline Endpoint

PLMVMS

p < 0.001

Blood Vitamin C

(means +/- SD)

70.667.4

94.3

68.1

0

20

40

60

80

100

120

140

Baseline Endpoint

PLMVMS

p < 0.001

Blood Vitamin E

(means +/- SD)

331299

335

716

0

200

400

600

800

1000

1200

Baseline Endpoint

PLMVMS

p < 0.001

Blood Carotenoids

Why Measure Carotenoids?

• Skin Carotenoids - An Important Indicator of the Body’s Antioxidant Defense System

– Site of action advantage of skin carotenoids– Carotenoids are an important part of the antioxidant

defense system– Skin carotenoids are influenced by oxidative stress

(smoking, sunlight exposure, urinary MDA)– Most convenient indicator of antioxidant defense– Same specificity issues as will other health tests

BioPhotonic Scanner:

Clinical Studies

Body Defense IndexUnder 10 K: Weak Antioxidant Defense Reading may indicate conditions with high oxidative stress - example in smokers who have a poor diet and do not take antioxidant supplements. _

10 to 17.5 K: Marginal Antioxidant DefenseCommon reading for people who do not take antioxidant supplements regularly and/or who eat diets low in fruits and vegetables._

17.6 to 25 K: Average Antioxidant DefenseCommon reading for people who eat diets higher in fruits and vegetables and/or take antioxidant supplements._

Above 25 K: Optimum Antioxidant DefenseCommon reading for people who eat healthy diets high in fruits and vegetables and/or take antioxidant supplements.

Raman Scan

70,0

00

65,0

00

60,0

00

55,0

00

50,0

00

45,0

00

40,0

00

35,0

00

30,0

00

25,0

00

20,0

00

15,0

00

10,0

00

5,0

000

300

200

100

0

Std. Dev = 8768.65

Mean = 19281

N = 1266.00

Mean: 19,072Std.Dev.: 8,828N = 1,375

Weak |Mar. | Avg. | Optimum

Raman Scanner Results & Ethnicity(means +/- SD)

0

5000

10000

15000

20000

25000

30000

35000

40000

n = 1162

n = 71

n = 65 n = 25 n = 8n = 12 n = 25

Wea

k |

Mar

. | A

vg.|

Op

t.

Smoking

19890

13030

17600 17591

1305611593

0

5000

10000

15000

20000

25000

30000

Non-Smokers

Smokers(all)

PastSmokers

< 1/day 1-5/day > 5/day

n = 1047

n = 58

p < 0.01

n = 39 n = 10

n = 16

n = 32

Sunlight Exposure

20085 1866016446

0

5000

10000

15000

20000

25000

30000

Low Moderate High

p < 0.01 p < 0.05

n = 550n = 716

n = 96

Wea

k |

Mar

. | A

vg.|

Op

t.

Scanner Readings vs. Fruit & Vegetable Intake

1682719669

2537723997

0

5000

10000

15000

20000

25000

30000

35000

40000

1 or Less 2 to 3 4 to 5 6 or More

n = 534n = 649

n = 137n = 30

p < 0.01 p < 0.01

Wea

k |

Mar

. | A

vg.|

Op

t.

Scanner Readings vs. LifePak Usage

1788820193

2571728848

0

5000

10000

15000

20000

25000

30000

35000

40000

None Irregular One/Day Two/Day

n = 59

n = 89

n = 192

n = 800

p < 0.01 p < 0.01

Effect of LifePak Supplementation

19950

26858

29463

33173

0

5000

10000

15000

20000

25000

30000

35000

40000

45000

Time (weeks)

0 4 8 12

p < 0.01 p < 0.01

Wea

k

| Mar

. | A

vg.|

Op

t.

Individual Changes, Days 1-28

0

5,000

10,000

15,000

20,000

25,000

30,000

35,000

40,000

45,000

Day 1 Day 28

n = 25

The ideal tool to measure

LifePak’s antioxidant effects in your own body

What’s Your Number???