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Inpharma 1538 - 20 May 2006 NG 273 may not be just a dream for insomnia According to the results of a phase II trial, NG 273 * substantially reduces the time to onset of persistent sleep in patients with transient insomnia. In this multicentre study, 369 such patients were randomised to receive 1mg (n = 73), 3mg (69), 10mg (72) or 20mg (71) doses of NG 273, or placebo, prior to assessment of Latency to Persistent Sleep (LPS) using a single-night, validated model of transient insomnia. The time taken to fall asleep, as defined by LPS, was significantly reduced with all doses of NG 273, compared with placebo. The durations of LPS were 17.8, 10.6, 7.8 and 6.6 minutes for the 1mg, 3mg, 10mg and 20mg doses of NG 273, respectively; all were significantly shorter than the 30.8 minutes for placebo. These results equated to 42%, 65%, 75% and 79% improvements for these doses, relative to placebo. NG 273 was well tolerated. * Neurogen Corporation; phase II for insomnia in the US Avalon Pharmaceuticals Inc. Avalon Pharmaceuticals Reports First Quarter 2006 Results. Media Release : 10 May 2006. Available from: URL: http:// www.avalonrx.com 809063561 1 Inpharma 20 May 2006 No. 1538 1173-8324/10/1538-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved

NG 273 may not be just a dream for insomnia

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Page 1: NG 273 may not be just a dream for insomnia

Inpharma 1538 - 20 May 2006

NG 273 may not be just a dream forinsomnia

According to the results of a phase II trial, NG 273*

substantially reduces the time to onset of persistentsleep in patients with transient insomnia.

In this multicentre study, 369 such patients wererandomised to receive 1mg (n = 73), 3mg (69), 10mg(72) or 20mg (71) doses of NG 273, or placebo, prior toassessment of Latency to Persistent Sleep (LPS) using asingle-night, validated model of transient insomnia.

The time taken to fall asleep, as defined by LPS, wassignificantly reduced with all doses of NG 273,compared with placebo. The durations of LPS were 17.8,10.6, 7.8 and 6.6 minutes for the 1mg, 3mg, 10mg and20mg doses of NG 273, respectively; all weresignificantly shorter than the 30.8 minutes for placebo.These results equated to 42%, 65%, 75% and 79%improvements for these doses, relative to placebo.NG 273 was well tolerated.* Neurogen Corporation; phase II for insomnia in the US

Avalon Pharmaceuticals Inc. Avalon Pharmaceuticals Reports First Quarter 2006Results. Media Release : 10 May 2006. Available from: URL: http://www.avalonrx.com 809063561

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Inpharma 20 May 2006 No. 15381173-8324/10/1538-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved