National Congress of the Italian Society of Immunology ... · Italian Society of Immunology, Clinical Immunology ... the Italian Society of Immunology, Clinical Immunology and Allergology

National Congress of theItalian Society of Immunology,Clinical Immunology and Allergology

Abano Terme (Padova), 25-28 May 2016Pietro d'Abano Congress Center

SECRETARIATRita RepizziTel. +39 333 [email protected]

ORGANIZING SECRETARIAT

Viale G. Matteotti, 7 50121 Florence, Italy

Tel. +39 055 50351Fax +39 055 5001912

[email protected]

Congress VenuePietro d'Abano Congress Center

Largo Marconi, 16 - 35031Abano Terme (PD), Italy

Tel. +39 049 8666111Fax + 39 049 8666113

Congress PresidentPaola Zanovello

Local Organizing CommitteeAlberto AmadoriGianpietro SemenzatoPaola Zanovello

Scientific CommitteeAlberto AmadoriFrancesco AnnunziatoFlavia BazzoniEnnio CarboneRaffaele De PalmaFrancesca Di RosaCecilia GarlandaFrancesca GranucciVito PistoiaAngela SantoniGianpietro SemenzatoAngelo VaccaPaola Zanovello

PRELIMINARY SCIENTIFIC PROGRAM

National Congress of the Italian Society of Immunology, Clinical Immunology and AllergologyAbano Terme (Padova) 25-28 May 2016

AUDITORIUM ROOM PIETRO D’ABANO ROOM ASTROLABIOWEDNESDAY 25 MAY

14.00 - 15.00OPENING CEREMONY &WELCOME ADDRESSES

15.00 - 17.00Plenary Symposium 1 IMMUNODEFICIENCY

17.00 - 18.00 Sponsored Symposium18.00 - 19.00 EFIS LECTURE19.00 WELCOME RECEPTION

THURSDAY 26 MAY

8.30 - 10.30Plenary Symposium 2 CELL DEVELOPMENT

AND REGULATION10.30 - 11.30 BREAK & POSTER VIEWING

11.30 - 13.00Workshop 1

INNATE IMMUNITY 1Workshop 2

EPIGENETICSWorkshop 3

AUTOIMMUNITY AND TOLERANCE13.00 - 14.30 LUNCH SYMPOSIA/MEET THE EXPERT & POSTER VIEWING

14.30 - 16.30Plenary Symposium 3

IMMUNO-RHEUMATOLOGY AND AUTOIMMUNITY

16.30 - 17.30 BREAK & POSTER VIEWING

17.30 – 19.00Workshop 4

INNATE IMMUNITY 2Workshop 5

NEUROIMMUNOLOGYWorkshop 6

ONCO-HEMATOLOGY 119.00 – 20.00 SIICA ASSEMBLY

FRIDAY 27 MAY


TISSUE AND MUCOSAL IMMUNOLOGY


11.30 - 13.00Workshop 7

TUMOR IMMUNOLOGY 1Workshop 8

MUCOSAL IMMUNITYWorkshop 9

ADAPTIVE IMMUNITY13.00 - 14.30 LUNCH SYMPOSIA/MEET THE EXPERT & POSTER VIEWING


TUMOR IMMUNOLOGY16.30 - 17.30 BREAK & POSTER VIEWING

17.30 - 19.00Workshop 10

TUMOR IMMUNOLOGY 2Workshop 11

IMMUNOREGULATIONWorkshop 12

ONCO-HEMATOLOGY 219.00 - 20.00 KEYNOTE LECTURE 1

SATURDAY 28 MAY

8.30 - 10.30Plenary Symposium 6INNATE IMMUNITY


11.30 - 13.00Workshop 13

VACCINE AND IMMUNOTHERAPYWorkshop 14

ALLERGIC INFLAMMATIONWorkshop 15

CELL SIGNALLING13.00 - 14.00 KEYNOTE LECTURE 2

WEDNESDAY 25 MAY 2016

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14.00 AUDITORIUM15.00 OPENING CEREMONY & WELCOME ADDRESSES LECTUREL1 The golden age of Medicine in Padova during Renaissance G. Thiene (Italy)

15.00 AUDITORIUM17.00 PLENARY SYMPOSIUM 1 - SIICA-FOCIS JOINT SYMPOSIUM IMMUNODEFICIENCY Chairpersons: C. Agostini (Italy), R. De Palma (Italy)

PS1.1 Pathogenesisofprimaryantibodydeficiencies I. Quinti (Italy)

PS1.2 Monogenic disorders of regulatory T cells: mechanisms and therapies T. Chatila (USA)

PS1.3 Functional SCID caused by LOF mutation in the CAR11 gene T. Giese (Germany)

PS1.4 Clinicalwholeexomesequencingfromprimaryimmunodeficiencies,experiencesfromStockholm O. Winqvist (Sweden)

PS1.5 ClinicalassociationsofbiallelicandmonoallelicTNFRSF13BvariantsinItalianprimaryantibodydeficiencysyndromes F. Pulvirenti, R. Zuntini, C. Milito, F. Specchia, G. Spadaro, M.G. Danieli, A. Pession, I. Quinti, S. Ferrari (Italy)

17.00 SPONSORED SYMPOSIUM18.00

18.00 AUDITORIUM19.00 EFIS LECTURE Chairperson: L. Moretta (Italy)

L2 Immune response to tuberculosis: how to control the most successful pathogen on earth S.H.E. Kaufmann (Germany)

THURSDAY 26 MAY 2016

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8.30 AUDITORIUM10.30 PLENARY SYMPOSIUM 2 CELL DEVELOPMENT AND REGULATION Chairperson: G. Matarese (Italy)

PS2.1 T lymphocyte differentiation, migration and immune regulation F. Sallusto (Switzerland)

PS2.2 New insights about the regulation of human Th17 cell response F. Annunziato (Italy)

PS2.3 IL-10regulationofcytokineexpression:focusonepigeneticmechanisms F. Bazzoni (Italy)

PS2.4 Deconstructing the pathway to memory B cell generation and maintenance in humans R. Carsetti (Italy)

PS2.5 iNKTcelldevelopmentrequiresmicroRNA-dependentmodulationofTGF-β signaling M. Fedeli, M. Riba, J.M. Garcia Manteiga, L. Tian*, V. Viganò, G. Rossetti, M. Pagani, A. Liston*, S. Abrignani, D. Cittaro, P. Provero, P. Dellabona, G. Casorati (Italy, *Belgium)

10.30 BREAK & POSTER VIEWING11.30

11.30 AUDITORIUM13.00 WORKSHOP 1 INNATE IMMUNITY 1 Chairpersons: G. Casorati (Italy), G. Ferlazzo (Italy)

W1.1 Characterizationandimmunomodulatoryroleofmultiplemyelomacell-derivedexosomesonhumanNKcell-mediatedfunctions:roleofTLR2 E. Vulpis, F. Cecere, R. Molfetta, G. Caracciolo, L. Digiacomo, G. Peruzzi, L. Masuelli, L. Simonelli, U. D’Oro, A. Soriani, C. Fionda, R. Paolini, M. Cippitelli, A. Santoni, A. Zingoni (Italy)

W1.2 Tolerogenic plasmacytoid dendritic cells migrate via afferent lymph to secondary lymphoid organs I. Bonaccorsi, S. Campana, C. De Pasquale, D. Oliveri, R. Conte, B. Morandi, R. Iemmo, G. Ferlazzo (Italy)

W1.3 Down-regulationofatypicalchemokinereceptorACKR2expressionbyhematopoieticprogenitorspromotesmyeloid cell mobilization and differentiation O. Bonavita, N. Caronni, B. Savino, M. Massara, L. Crisafulli, F. Ficara, A. Mantovani, M. Locati, R. Bonecchi (Italy)

W1.4 TherapeuticimmunostimulationmediatedbyRIG-Ipathwayactivation J. Hiscott (Italy)

W1.5 DendriticcellsproduceVEGF-Ainhumaninflamedsecondarylymphoidorgans V. Gianello, V. Salvi, W. Vermi, S. Lonardi, V. Gagliostro, A. Naldini, S. Sozzani, D. Bosisio (Italy)

13.00 LUNCH SYMPOSIA/MEET THE EXPERT & POSTER VIEWING14.30


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14.30 AUDITORIUM16.30 PLENARY SYMPOSIUM 3 - SIICA-MIT JOINT SYMPOSIUM IMMUNO-RHEUMATOLOGY AND AUTOIMMUNITY Chairpersons: I. Kacskovics (Hungary), L. Punzi (Italy)

PS3.1 New advances in the management of SLE A. Doria (Italy)

PS3.2 Myeloidcellsignallinginautoimmuneinflammation A. Mocsai (Hungary)

PS3.3 Pathogeneticmolecularandimmunologicalmechanismsoffibrosis:thesystemicsclerosisparadigm A. Gabrielli (Italy)

PS3.4 Citrullination and autoimmunity G. Valesini (Italy)

PS3.5 Pathogenicpathwaysinanti-phospholipidsyndromeandnewtherapeutictools C.B. Chighizola (Italy)


17.30 AUDITORIUM19.00 WORKSHOP 4 INNATE IMMUNITY 2 Chairpersons: A. Rubartelli (Italy), P. Zanovello (Italy)

W4.1 Proton-pumpinhibitorsprotectmicefromacutesystemicinflammationandinducelongtermcross-tolerance A. Rubartelli, S. Carta, E. Balza, P. Piccioli, R. Lavieri, M. Gattorno, C. Semino, P. Castellani (Italy)

W4.2 Theabundantnaturalkiller(NK)cellsinmultiplemyelomapatientsareenrichedinproliferatingCD56dim-CD94low highly cytotoxic NK cell subset C. Barberi, S. Campana, C. De Pasquale, A. Allegra, G. Ferlazzo (Italy)

W4.3 The long pentraxin PTX3 and the alternative complement pathway cooperate in the immune response to Aspergillus fumigatus R. Parente, F. Petroni, M. Sironi, S. Valentino, B. Bottazzi, A. Mantovani, A. Inforzato (Italy)

W4.4 Interleukin-1receptor8(IL-1R8)playsacrucialroleinnaturalkillercelldifferentiationandfunction M. Molgora, E. Bonavita, A. Ponzetta, M. Barbagallo, N. Polentarutti, S. Jaillon, F. Riva, E. Magrini, G. Benigni, G. Bernardini, A. Santoni, A. Mantovani, C. Garlanda (Italy)

W4.5 Human BDCA1+ dendritic cells are potent activator of tonsillar ILC3 S. Campana, D. Oliveri, C. Barberi, C. De Pasquale, R. Cavaliere, G. Ferlazzo (Italy)

19.00 SIICA ASSEMBLY20.00


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11.30 ROOM PIETRO D'ABANO13.00 WORKSHOP 2 EPIGENETICS Chairpersons: S. Indraccolo (Italy), M. Locati (Italy)

W2.1 Long noncoding RNAs: new players in plasticity and new therapeutic opportunities in human immune system I. Panzeri, M. Lorenzo, P. Gruarin, A. Dardanelli, S. Marchesi, V. Ranzani, A. Arrigoni, R.J.P. Bonnal, G. Rossetti, S. Abrignani, M. Pagani (Italy)

W2.2 IdentificationandcharacterizationofLongnon-codingRNAsinprimaryhumanmonocytesandneutrophils B. Mariotti, M. Castellucci, F.M.A. Bianchetto, N. Tamassia, M.A. Cassatella, F. Bazzoni (Italy)

W2.3 DoesepigeneticsplayaroleinIL-10productionbyBlymphocytes? S. Tonon, F. Mion, J. Dong*, H.-D. Chang*, A. Radbruch*, M. Colombo, S. Canevari, M. Dugo, D. Cesselli, C.E.M. Pucillo (Italy, *Germany)

W2.4 Differential expression of DNA repeats in human CD4+ T cell subsets F. Marasca, S. Sinha, E. Provasi, S. Abrignani, M. Pagani, B. Bodega (Italy)

17.30 ROOM PIETRO D'ABANO19.00 WORKSHOP 5 NEUROIMMUNOLOGY Chairpersons: R. Furlan (Italy), A. Uccelli (Italy)

W5.1 InvariantnaturalkillerTcellsinsecondaryprogressivemultiplesclerosispatientsdisplaypro-inflammatoryprofiles E. Bianchini, S. De Biasi, A.M. Simone, M. Nasi, D. Ferraro, F. Vitetta, L. Gibellini, M. Pinti, C. Del Giovane, P. Sola, A. Cossarizza (Italy)

W5.2 CCRL2 regulates M1/M2 polarization during EAE recovery phase A. Del Prete, C. Mazzon, L. Zanotti, L. Wang, E. Fontana, V. Salvi, P.L. Poliani, S. Sozzani (Italy)

W5.3 Estrogenreceptor-α (ERα) expression in human lymphocytes of multiple sclerosis patients before and after pregnancy M. Lo Pizzo, G. Di Liberto, D. Di Liberto, P. Ragonese, S. Realmuto, G. Salemi, F. Dieli (Italy)

W5.4 CD8+Tcellreactivityagainstapoptoticself-epitopesinmultiplesclerosis I. Cammarata, C. Martire, A. Citro, M. Albanese, C. Buscarinu, M. Salvetti, D. Centonze, V. Barnaba (Italy)

W5.5 Selectiverecognitionofviralandself-antigensbyTh1-andTh1/17-cellsinmultiplesclerosisrevealsdistinctrolesinCNSimmune-surveillanceandrelapses M. Paroni, V. Maltese, M. De Simone, V. Ranzani, P. Larghi, C. Fenoglio, A. Pietroboni, M. De Riz, D. Galimberti, M. Pagani, E. Scarpini, S. Abrignani, J. Geginat (Italy)


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11.30 ROOM ASTROLABIO13.00 WORKSHOP 3 AUTOIMMUNITY AND TOLERANCE Chairpersons: V. Barnaba (Italy), C. Pucillo (Italy)

W3.1 TheroleofIL-1:fromautoimmunitytoauto-inflammation P. Sfriso (Italy)

W3.2 ImmunologicaltolerancemechanismscontrollinghumanautoreactiveCD8+Tcellsinhealthyandautoimmune conditions C. Martire, I. Cammarata, A. Citro, G. Peruzzi, F. Guerrieri, R. Scrivo, G. Valesini, V. Barnaba (Italy)

W3.3 Decreased function of Fas and variations of the perforin gene in adult patients with primary immune thrombocytopenia E. Boggio, C.L. Gigliotti, N. Clemente, G. Gaidano, A. Chiocchetti, R. Fanin, U. Dianzani, F. Zaja (Italy)

W3.4 Inflammatorymicroenvironmentinhibitstype-1regulatorycellsimmunomodulatorypropertiesinIntestinalbowel disease P. Larghi, S. Alfen, F. Facciotti, N. Gagliani*, M. Paroni, C. Ciafardini, S. Maglie, M. Moro, M.C. Crosti, D. Conte, F. Caprioli, S. Abrignani, R.F. Flavell*, J. Geginat (Italy, *USA)

17.30 ROOM ASTROLABIO19.00 WORKSHOP 6 ONCO-HEMATOLOGY 1 Chairpersons: I. Airoldi (Italy), G. Semenzato (Italy)

W6.1 IMiDs:immunostimulationandcytotoxicityinfirstlineandrelapsedmultiplemyeloma R. Zambello (Italy)

W6.2 Autophagy,assurvivalmachinery,isrelatedtobortezomib-resistanceinbonemarrowfibroblastsfrommultiple myeloma patients V. Desantis, L. Di Marzo, D. Vergara, K. De Veirman*, E. Menu*, M. Maffia, K. Vanderkerken*, A. Vacca, M.A. Frassanito (Italy, *Belgium)

W6.3 Reducedp66Shcexpressioninchroniclymphocyticleukemia(CLL)BcellsenhancesCXCR4/CCR7recyclingand impairs S1P1 expression promoting their lymph node accumulation L. Patrussi, N. Capitani, V. Martini, V. Trimarco, F. Frezzato, M. Pizzi, F. Marino, G. Semenzato, L. Trentin, C.T. Baldari (Italy)

W6.4 Identificationofgranulocyticmyeloid-derivedsuppressorcells(G-MDSCs)intheperipheralbloodofHodgkinandnon-Hodgkinlymphomapatients O. Marini, C. Spina, E. Mimiola, A. Cassaro, G. Malerba, G. Todeschini, O. Perbellini, M.T. Scupoli, G. Carli, D. Facchinelli, M.A. Cassatella, P. Scapini, C. Tecchio (Italy)

W6.5 Geneticcharacterizationofimmunoglobulineheavyvariable,diversityandjoininggenesin471patientswithchroniclymphocyticleukemia A. Visentin, M. Facco, E. Pagnin, V. Martini, F. Frezzato, V. Trimarco, F. Severin, S. Teolato, S. Imbergamo, F. Raggi, L. Martinello, E. Scomazzon, G. Semenzato, L. Trentin (Italy)

W6.6 Expressionofthep66ShcproteinadaptorisregulatedbytheactivatoroftranscriptionSTAT4innormalandCLL B cells F. Cattaneo, L. Patrussi, N. Capitani, L. Trentin, G. Semenzato, C.T. Baldari (Italy)

FRIDAY 27 MAY 2016

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8.30 AUDITORIUM10.30 PLENARY SYMPOSIUM 4 TISSUE AND MUCOSAL IMMUNOLOGY Chairperson: A. Cavani (Italy)

PS4.1 NewinsightsintothefunctionofIGD:aroleinallergenprotection? A. Cerutti (Spain)

PS4.2 The gut vascular barrier: a new anatomical structure M. Rescigno (Italy)

PS4.3 Reinstalling immunoregulatory tryptophan catabolism in autoimmune diabetes U. Grohmann (Italy)

PS4.4 DeterminantsofhepaticeffectorCD8+Tcelldynamics L. Guidotti (Italy)

PS4.5 Differentialcytokinesandphenotypeprofilesinintestinalmucosabetweenpediatricpatientswithovertorpotential celiac disease S. Vitale, V. Santarlasci, S. Picascia, R. Auricchio, F. Liotta, L. Cosmi, F. Annunziato, R. Troncone, C. Gianfrani (Italy)


11.30 AUDITORIUM13.00 WORKSHOP 7 TUMOR IMMUNOLOGY 1 Chairpersons: P. Allavena (Italy), M. Cippitelli (Italy)

W7.1 Neutrophils are protective in cancerogenesis by altering tumor microenvironment and controlling intestinal microbiota A. Ponzetta, M.R. Galdiero, M. Barbagallo, M. Molgora, E. Magrini, E. Bonavita, C. Garlanda, A. Mantovani, S. Jaillon (Italy)

W7.2 Transcriptionallandscapeofhumantissuelymphocytesunveilsuniquenessoftumor-infiltratingTregulatory cells M. De Simone, A. Arrigoni, G. Rossetti, P. Gruarin, V. Ranzani, C. Politano, R.J.P. Bonnal, I. Panzeri, V. Vaira, S. Bosari, A. Palleschi, L. Santambrogio, G. Bovo, N. Zucchini, M. Totis, L. Gianotti, J. Geginat, S. Abrignani, M. Pagani (Italy)

W7.3 InvolvementofiNKTcellsinthecontrolandprognosisofchroniclymphocyticleukemia F. Gorini, L. Azzimonti, L. Scarfò, M. Ponzoni, C. Tripodo, A. Gulino, F. Caligaris Cappio, P. Ghia, M. Bellone, P. Dellabona, G. Casorati, C. de Lalla (Italy)

W7.4 EarlytriggeringofnaturalkilleranddendriticcellduringtheantitumortherapeuticresponseinducedbyTNFa tumor vessel delivery and melphalan E. Balza, S. Zanellato, A. Poggi, D. Reverberi, A. Rubertelli, L. Mortara (Italy)

W7.5 Residualtumormicro-fociandoverwhelmingregulatoryTlymphocyteinfiltrationarethecausesofbladdercancer recurrence G. Filaci, D. Fenoglio, A. Parodi, F. Kalli, F. Ferrera, G. Nasi, M. Curto, G. Conteduca, S. Tardito, C. Bernardi, P. Traverso, L. Mastracci (Italy)

FRIDAY 27 MAY 2016

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13.00 LUNCH SYMPOSIA/MEET THE EXPERT & POSTER VIEWING14.30

14.30 AUDITORIUM16.30 PLENARY SYMPOSIUM 5 - SIICA-NIBIT JOINT SYMPOSIUM TUMOR IMMUNOLOGY Chairpersons: P.F. Conte (Italy), V. Russo (Italy)

PS5.1 RedirectingandimprovingCytokine-InducedKiller(CIK)cellactivityagainstsolidtumor A. Rosato (Italy)

PS5.2 Reprogramming of myeloid cells in cancer therapy A. Sica (Italy)

PS5.3 Microbiome and multiple myeloma progression M. Bellone (Italy)

PS5.4 Epigeneticreprogrammingofcancercellstoimprovetheefficacyofimmunotherapy M. Maio (Italy)

PS5.5 Hematopoieticexpressionoftheatypicalchemokinereceptor2inhibitstherecruitmentofanti-metastaticneutrophils M. Massara, O. Bonavita, B. Savino, N. Caronni, C. Recordati, M. Sironi, A. Mantovani, M. Locati, R. Bonecchi (Italy)


17.30 AUDITORIUM19.00 WORKSHOP 10 TUMOR IMMUNOLOGY 2 Chairpersons: V. Bronte (Italy), P. Dellabona (Italy)

W10.1 ImmunometaboliccheckpointsofTregperformanceincancer I. Pacella, C. Focaccetti, E. Timperi, V. Barnaba, S. Piconese (Italy)

W10.2 C1qasapotentialnewtherapeuticaltargetinmalignantpleuralmesothelioma C. Agostinis, R. Vidergar, M. Confalonieri, P. Geri, U. Kishore*, R. Bulla (Italy, *United Kingdom)

W10.3 Naturalkillercellscontrolthebreastcancerandrelatedcancerstemcellshematologicalspreading R. Tallerico, L. Conti, S. Lanzardo, R. Sottile*, C. Garofalo, A.K. Wagner*, M.H. Johansson*, C.M. Cristiani, K. Kärre*, E. Carbone, F. Cavallo (Italy, *Sweden)

W10.4 Phenotypicandfunctionaladaptationoftumorinfiltratinglymphocytesinnon-smallcelllungcancer E. Timperi, C. Focacetti, A. Grimaldi, D. Gallerano, F. Facciolo, M. Panetta, P. Nisticò, V. Barnaba (Italy)

W10.5 Migrationstimulatingfactorasapossiblemarkerofmacrophagepolarizationinthetumor

microenvironment T. Gulic, I. Laface, A. Inforzato, M. Sironi, R. Leone, C. Lage Crespo, F. Grizzi, B. Bottazzi, P. Allavena, D. Rukavina* (Italy, *Croatia)

FRIDAY 27 MAY 2016

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19.00 AUDITORIUM20.00 KEYNOTE LECTURE 1 Chairperson: A. Vacca (Italy)

KL1 Imaging immunity: creating a spatiotemporal understanding of host defense R. Germain (USA)

11.30 ROOM PIETRO D'ABANO13.00 WORKSHOP 8 MUCOSAL IMMUNITY Chairpersons: C. Gianfrani (Italy), F. Granucci (Italy)

W8.1 Non-IPEXautoimmuneenteropathyisassociatedwithuncontrolledIL-17productionbyintraepitheliallymphocytes M. Paroni, A. Magarotto, S. Tartari, G. Nizzoli, P. Larghi, U. Gianelli, M. Pagani, L. Elli, S. Abrigani, D. Conte, F. Caprioli, J. Geginat (Italy)

W8.2 PrimaryandchronicHIVinfectiondifferentlymodulatesmucosalVdelta1andVdelta2T-cellsdifferentiationprofileandeffectorfunctions E. Cimini, C. Agrati, G. D’Offizi, C. Vlassi, R. Casetti, A. Sacchi, R. Lionetti, V. Bordoni, N. Tumino, P. Scognamiglio, F. Martini (Italy)

W8.3 Cooperativeeffectsofbacterialbioproductsandfungionmastcellactivation M. De Zuani, B. Frossi, T. Zelante, A. Arzese, G. Paolicelli, V. Oikonomou, L. Romani, C. Pucillo (Italy)

W8.4 slan/M-DC8+cellsconstituteadistinctsubsetofdendriticcellsinhumantonsils A. Micheletti, G. Finotti, F. Calzetti, W. Vermi, M.A. Cassatella (Italy)

17.30 ROOM PIETRO D'ABANO19.00 WORKSHOP 11 IMMUNOREGULATION Chairpersons: A. Amadori (Italy), S. Mandruzzato (Italy)

W11.1 Unexpectedrelationshipbetweenferritinheavychainandeukaryoticcellsimmunogenicity R. Sottile, F. Trecroci*, M.C. Faniello*, B. Quaresima*, R. Tallerico*, C. Garofalo*, A. Anichini*, G. Cuda*, A. Cozzi*, S. Levi*, K. Kärre, F.S. Costanzo*, E. Carbone* (Sweden, *Italy)

W11.2 IL-10producedbyhumanCD1c+DCshapesCD8+T-cellprimingandpromoteshomeostaticproliferationofCD8+memoryT-cells G. Nizzoli, P. Larghi, M. Paroni, R. De Francesco, M. Pagani, S. Abrignani, J. Geginat (Italy)

W11.3 ISG15 protects regulatory T cells from IFNα-inducedcelldeath S. Piconese, I. Pacella, M. Severa, F. Rizzo, E.M. Coccia, V. Barnaba (Italy)

W11.4 Clinical response and analysis of regulatory T cells/t helper 17 cell ratio in patients with active systemic

Lupus erythematosus on treatment with belimumab V. Desantis, A. Venturelli, L. Di Marzo, V. Racanelli, M. Prete, F. Dammacco, A. Vacca, M.A. Frassanito (Italy)

W11.5 Arginase1presidesoverimmunoregulatorysignalingmediatedbyindoleamine2,3-dioxygenase1indendritic cells G. Mondanelli, M.T. Pallotta, A. Iacono, S. Ugel, V. Bronte, C. Volpi, U. Grohmann (Italy)

FRIDAY 27 MAY 2016

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11.30 ROOM ASTROLABIO13.00 WORKSHOP 9 ADAPTIVE IMMUNITY Chairpersons: F. Dieli (Italy), S. Piconese (Italy)

W9.1 IdentificationofhumanfollicularhelperTcellsspecificmiRNAskeytodifferentiationandfunction M. Lorenzo, A. Ripamonti, E. Provasi, M. De Simone, G. Rossetti, S. Curti, V. Ranzani, A. Arrigoni, R.J.P. Bonnal, S. Torretta, L. Pignataro, M. Pagani, S. Abrignani (Italy)

W9.2 Pro-resolvinglipidmediatorsD-seriesresolvinsandmaresin1arecriticalinmodulatingTcellresponses:anovelroleforregulationofcell-mediatedadaptiveimmunity V. Chiurchiu, A. Leuti, J. Dalli*, M. Maccarrone, C. Serhan* (Italy, *USA)

W9.3 Bcellsincancerimmunology:theeffectsofintestinalcanceronsetonIL-10-producingBcells F. Mion, S. Vetrano, S. Tonon, A. Burocchi, A. Piontini, L. Petti, M. Colombo, C.E. Pucillo (Italy)

W9.4 CharacterizationofCD8andCD4T-cellsresponsetotheQuantiFERON-TB-Plusantigens E. Petruccioli, T. Chiacchio, I. Pepponi, V. Vanini, G. Gualano, G. Cuzzi, D. Cirillo, F. Palmieri, D. Goletti (Italy)

W9.5 Antigen B multiepitope peptides for the diagnosis of Cystic echinococcosis L. Petrone, V. Vanini, M. Amicosante, A. Corpolongo, E. Busi Rizzi, A. Ludovisi, G. Ippolito, E. Pozio, A. Teggi, D. Goletti (Italy)

17.30 ROOM ASTROLABIO19.00 WORKSHOP 12 ONCO-HEMATOLOGY 2 Chairpersons: V. Pistoia (Italy), L. Trentin (Italy)

W12.1 Thetranscriptionalco-repressorSin3AcontributestotheoncogenicpotentialofSTAT3inALK+ALCL G. Gambi, L. Icardi, V. Basso, M. Ponzoni, A. Mondino (Italy)

W12.2 Cortactin:acheckpointmoleculeformigrationandinvasioninchroniclymphocyticleukemicBcells V. Martini, C. Gattazzo, F. Frezzato, V. Trimarco, G. Chiodin, F. Severin, F. Raggi, L. Martinello, M. Pizzi, A. Visentin, E. Scomazzon, F. Marino, M. Facco, G. Semenzato, L. Trentin (Italy)

W12.3 NOTCH1inhibitionregulatesevolutionaryconservedmiRNAsinT-celllymphoblasticleukemia V. Saccomani, E. Piovan, A. Grassi, J. Yu*, F. Bordin, S. Minuzzo, V. Tosello, P. Zanovello (Italy, *USA)

W12.4 Inhibitionofjanuskinases2/signaltransducersandactivatorsoftranscription3pathwayleadstoapopto-sisinchroniclymphocyticleukemiacells F. Severin, F. Frezzato, V. Martini, V. Trimarco, F. Raggi, L. Martinello, A. Visentin, E. Scomazzon, G. Chiodin, M. Facco, G. Semenzato, L. Trentin (Italy)

W12.5 Prevalenceandriskfactorsofautoimmunediseasesinpatientswithchroniclymphocyticleukemia A. Visentin, S. Imbergamo, F. Frezzato, C. Gurrieri, V. Martini, V. Trimarco, F. Severin, E. Scomazzon, F. Raggi, L. Martinello, M. Facco, G. Semenzato, L. Trentin (Italy)

SATURDAY 28 MAY 2016

12


8.30 AUDITORIUM10.30 PLENARY SYMPOSIUM 6 INNATE IMMUNITY Chairperson: M. Cassatella (Italy)

PS6.1 RoleoftheatypicalchemokinereceptorCCRL2ininflammation S. Sozzani (Italy)

PS6.2 ThelongpentraxinPTX3asaparadigmofhumoralinnateimmunity:frommicroberecognitionandregula-tionofinflammationtotissueremodeling

C. Garlanda (Italy)

PS6.3 Differentiationofhumangroup3innatelymphoidcells E. Montaldo (Italy)

PS6.4 Regulationofinnatelymphoidcells M. Colonna (USA)

PS6.5 IFNαenhancestheproductionofIL-6byhumanneutrophilsactivatedviaTLR8 M. Zimmermann, F. Arruda-Silva, C. Lunardi, M.A. Cassatella, N. Tamassia (Italy)


11.30 AUDITORIUM13.00 WORKSHOP 13 VACCINE AND IMMUNOTHERAPY Chairpersons: F. Cavallo (Italy), P. De Berardinis (Italy)

W13.1 IdentificationofaHLA-A*0201-restrictedimmunogenicepitopefromtheuniversaltumorantigenDEPDC1 A. Tosi, R. Sommaggio, E. Cappuzzello, P. Zanovello, A. Rosato (Italy)

W13.2 Microvescileasnovelimmunogenformulationforanti-tumorvaccines:impactonantigencross-processingand presentation in dendritic cells F. Battisti, I.G. Zizzari, C. Napoletano, H. Rahimi Koshkaki, M. Nuti, A. Rughetti (Italy)

W13.3 Man’sbestfriend:areal-lifemodelfortestinggeneticcancervaccines J. Impellizeri, S. Bandini*, L. Luberto*, A. Gavazza*, G. Lubas*, E. Greissworth, D. Jemiolo, G. Ciliberto*, L. Aurisicchio* (USA, *Italy)

W13.4 Mouse breast tumor growth and metastasis inhibition via immunotargeting of the cancer stem cell antigen xCT S. Lanzardo, L. Conti, R. Rooke*, R. Ruiu, G. Donofrio, F. Pericle**, E. Bolli, V. Rolih, A. Laroche, I. Merighi, R. Calogero, F. Cavallo (Italy, *France, **USA)

W13.5 NoveladjuvantAlum-TLR7agreatlypotentiatesimmuneresponsetoglyconjugatevaccines C. Buonsanti, C. Balocchi, C. Harfouche, F. Corrente, L. Galli Stampino, F. Mancini, P. Malyala*, S. Bufali, B. Baudner, E. De Gregorio, N. Valiante*, D. O’Hagan*, R. Rappuoli, U. D’Oro (Italy, *USA)

SATURDAY 28 MAY 2016

13


13.00 AUDITORIUM14.00 KEYNOTE LECTURE 2 Chairperson: A. Santoni (Italy)

KL2 Memory-likeNKcellsgeneratedduringviralinfection A. Moretta (Italy)

11.30 ROOM PIETRO D'ABANO13.00 WORKSHOP 14 - SIICA-SIAAIC JOINT WORKSHOP ALLERGIC INFLAMMATION Chairpersons: R. Paolini (Italy), M. Triggiani (Italy)

W14.1 MolecularmechanismsregulatingFcepsilonRIendocytictraffickinginmastcells R. Paolini (Italy)

W14.2 Proinflammatoryandvasoactivemediatorsinchronicurticaria M. Triggiani (Italy)

W14.3 Characterization of mast cell derived exosomes: role of FcεRI-IgEcomplexes R. Molfetta, L. Quatrini, M. Lecce, B. Zitti, A. Zingoni, L. Masuelli, L. Simonelli, G. Caracciolo, S. Palchetti, A. Santoni, R. Paolini (Italy)

W14.4 ModulatingallergicresponsebyunlockingthestructureofthemajorParietariaallergens D. Di Blasi, A. Bonura, F. Gervasi, C. Uasuf, M.R. Melis, P. Colombo, M.A. Ragusa (Italy)

W14.5 DendriticcellsdifferentiationismodulatedbythenematodeparasiteAnisakispegreffii C. Napoletano, S. Mattiucci, A. Colantoni, M. Nuti, A. Rughetti (Italy)

11.30 ROOM ASTROLABIO13.00 WORKSHOP 15 CELL SIGNALLING Chairpersons: A. Leonardi (Italy), G. Natoli (Italy)

W15.1 MusculinisexpressedbyhumanTh17cellsanddown-regulatestheirresponsetoIL-2byinhibitingSTAT5serine 193 phosphorylation V. Santarlasci, A. Mazzoni, M. Capone, M.C. Rossi, L. Maggi, G. Montaini, R. De Palma, F. Liotta, L. Cosmi, F. Annunziato (Italy)

W15.2 RoleofIP3R3inCD14-NFATpathwayactivation L. Marongiu, M. Di Gioia, V. Poli, L. Sironi, M. Collini, I. Zanoni, F. Granucci (Italy)

W15.3 Phosphatidylinositol4-phosphate5-kinase αisacriticalregulatorofCD28signalingfunctions N. Porciello, M. Kunkl, M. Muscolini, C. Camperio, S. Caristi, C. Capuano, A. Viola, R. Galandrini, L. Tuosto (Italy)

W15.4 Acomparisonbetweenasecondandthird-generationchimericantigenreceptorrevealsapotentialdetrimental effect of hyperstimulation G. Zuccolotto (Italy)

W15.5 Insightsintointerleukin-10-activatedSTAT3transcriptionalfunctionviagenome-widechromatinoccupancyand gene expression analysis M. Castellucci, B. Mariotti, M. Mokry*, M. Rossato*, T. Radstake*, F. Bianchetto, N. Tamassia, M. Cassatella, F. Bazzoni (Italy, *The Netherlands)

POSTER SESSIONS

14


POSTER AREA POSTER SESSION I - THURSDAY 26 MAY

P1 - INNATE IMMUNITY

P1.1 Differentialbiologicalactivitiesofswineinterferon-alphasubtypes C. Zanotti, E. Razzuoli, H. Crooke*, O. Soule*, G. Pezzoni, M. Ferraris, A. Ferrari, M. Amadori (Italy, *United Kingdom)

P1.2 Roleofneutrophilsinanimiquimod-inducedmousemodelofpsoriasis D. Bevilacqua, S. Costa, M.A. Cassatella, G. Girolomoni, P. Scapini (Italy)

P1.3 Molecularmechanismsregulatingvincristine-mediatedNKG2D(ULBP-1andMICA)andDNAM-1(PVR)ligandinductionon multiple myeloma cells C. Borrelli, B. Ricci, A. Zingoni, R. Molfetta, C. Fionda, R. Paolini, M. Cippitelli, M.P. Abruzzese, M.R. Ricciardi, M.T. Petrucci, A. Soriani, A. Santoni (Italy)

P1.4 TLR4 activation elicits a functionally discrete subset of TSLPR+ human monocytes F. Borriello, R. Iannone, V. Vastolo, G. Petrosino, S. Di Somma, F. Visconte, M. Raia, G. Scalia, S. Loffredo, F. Granata, L. Del Vecchio, G. Portella, G. Marone (Italy)

P1.5 Pro-lymphangiogenicpropertiesofIFN-g-activateddendriticcells D. Bosisio, V. Gagliostro, P. Seeger, V. Salvi, E. Garrafa, R. Bresciani, S. Sozzani (Italy)

P1.6 Ratioofmonocytestolymphocytesinperipheralbloodofpatientswithtuberculosis:anoldbiomarkerrevisited N. Caccamo, M.P. La Manna, V. Orlando, T. Prezzemolo, F. Dieli, G. Cuzzi, D. Goletti (Italy)

P1.7 NK cells and human cytomegalovirus: role of viral immediate early proteins and of the DNA damage response pathway intheexpressionofligandsoftheNKG2DandDNAM-1activatingreceptors B. Pignoloni, C. Fionda, V. Dell’Oste, A. Luganini, M. Cippitelli, A. Zingoni, S. Landolfo, G. Gribaudo, A. Santoni, C. Cerboni (Italy)

P1.8 PersistentintrahepaticVgamma9Vdelta2T-cellsimpairmentinchronicHCV-infectedpatients E. Cimini, V. Bordoni, U. Visco-Comandini, M. Montalbano, R. Lionetti, A. Sacchi, R. Casetti, N. Tumino, G. D’Offizi, M.R. Capobianchi, F. Martini, C. Agrati (Italy)

P1.9 HepatitisBVirusaffectsdendriticcellactivationandtheircross-talkwithnaturalkillercells C. De Pasquale, S. Campana, C. Barberi, T. Pollicino, G. Ferlazzo (Italy)

P1.10 Predominanceoftype1innatelymphoidcellsintherectalmucosaofpatientswithnon-celiacwheatsensitivity:reversalafterawheat-freediet D. Di Liberto, P. Mansueto, A. D’Alcamo, M. Lo Pizzo, E. Lo Presti, G. Geraci, F. Fayer, G. Guggino, G. Iacono, F. Dieli, A. Carroccio (Italy)

P1.11 Anautocrinesurvivalloopmediatedbystemcellfactor/c-kitinmousedendriticcells A. Barroeta Seijas, S. Simonetti, D. Runci, S. Vitale, A. Quinci, A. Soriani, M. Criscuoli, I. Filippi, A. Naldini, A. Santoni, F. Di Rosa (Italy)

P1.12 Endogenously produced TNFαcontributestotheexpressionofCXCL10inIFNλ3-activatedplasmacytoiddendriticcells G. Finotti, N. Tamassia, F. Calzetti, M.A. Cassatella (Italy)

P1.13 MicroRNAprofilinginhumanneutrophilsduringactivation S. Ghasemi, B. Mariotti, N. Tamassia, F. Bianchetto, M.A. Cassatella, F. Bazzoni (Italy)

P1.14 GammadeltaTcellsareexpandedinperipheralbloodandsynovialfluidofPsApatientsandareactivatedthroughIL9Rand IL23R transduction signalling G. Guggino, F. Ciccia, D. Di Liberto, M. Lo Pizzo, P. Ruscitti, P. Cipriani, J.J. Fournie*, R. Giacomelli, F. Dieli, G. Triolo (Italy, *France)

P1.15 ExpressionofCD206oncirculatingmonocytescorrelateswithactivetuberculosis M.P. La Manna, B. Tamburini, V. Orlando, N. Caccamo, F. Dieli (Italy)

POSTER SESSIONS

15


P1.16 ActivationandselectiveIL-17responseofhumanVγ9Vδ2TlymphocytesbyTLR-activatedplasmacytoiddendriticcells E. Lo Presti, N. Caccamo, V. Orlando, F. Dieli, S. Meraviglia (Italy)

P1.17 Human circulating group 2 innate lymphoid cells can express CD154 and promote IgE production L. Maggi, G. Montaini, A. Mazzoni, M. Capone, M.C. Rossi, V. Santarlasci, F. Liotta, O. Rossi, E. Maggi, L. Cosmi, F. Annunziato (Italy)

P1.18 ConservedresponsetoIL-12/IL-15andnaturalcytotoxicityreceptorInducibilityofNKcellsareahallmarkofefficientcontrol of circulating HIV DNA reservoir in HIV infected patients F. Marras, F. Bozzano, A. Di Biagio, L. Nicolini, L. Tarmasso, C. Dentone, E. Pontali, G. Orofino, M. Setti, L. Moretta, C. Orlandi, A. Casabianca, M. Magnani, A. De Maria (Italy)

P1.19 NCR expression/inducibility on NK cells is associated to different levels of control of HIV infection in Virologically discordant non progressor (VDNP) and in HIV controller (HIC) patients F. Marras, F. Bozzano, A. Di Biagio, L. Nicolini, L. Tarmasso, M. Setti, C. Dentone, E. Pontali, G. Orofino, E. Mantia, L. Moretta, C. Orlandi, A. Casabianca, M. Magnani, A. De Maria (Italy)

P1.20 Humancirculatinggroup2innatelymphoidcellscanbeinducedtoproduceIFN-γbyIL-12 G. Montaini, L. Maggi, A. Mazzoni, M. Capone, M.C. Rossi, V. Santarlasci, E. Maggi, F. Liotta, L. Cosmi, F. Annunziato (Italy)

P1.21 PhenotypicandfunctionalcharacterizationofCD56lowCD16lowNKcellsubsetinbonemarrowandperipheralbloodofpediatricleukemicpatientsafterTcell-depletedhematopoieticstemcelltransplantation P. Nisti, H. Stabile, S. Morrone, D. Pagliara, A. Bertaina, F. Locatelli, A. Santoni, A. Gismondi (Italy)

P1.22 NKcellsimmunoprofilinginaHIVpositive,elitecontrollerpatient E. Palella, C. Torti, C. Garofalo, M. Mazzitelli, R. Tallerico, R. Sottile*, G.S. Barreca, L. Galati, A. Focà, E. Carbone (Italy, *Sweden)

P1.23 Assessingtheautophagicfluxinprimarycellsfrompatientswithtuberculosis I. Pepponi, E. Petruccioli, A. Romagnoli, G. Cuzzi, G.M. Fimia, D. Goletti (Italy)

P1.24 RoleoftheclassicalandlectincomplementpathwaysinthePTX3-mediatedimmuneresponsetoAspergillus fumigatus F. Petroni, R. Parente, M. Sironi, S. Valentino, B. Bottazzi, A. Mantovani, A. Inforzato (Italy)

P1.25 Hypoxiareprogramshumanmacrophagestowardsaproinflammatorydirection:roleofTREM-1 F. Raggi, S. Pelassa, D. Pierobon, M. Giovarelli, L. Varesio, M.C. Bosco (Italy)

P1.26 HIVinfectionofmonocytes-deriveddendriticcellsinhibitsVgamma9Vdelta2Tcellsfunctions A. Sacchi, A. Rinaldi, N. Tumino, R. Casetti, C. Agrati, F. Turchi, V. Bordoni, E. Cimini, F. Martini (Italy)

P1.27 Arylhydrocarbonreceptor:anoveltargetfortheanti-inflammatoryactivityofstatintherapy A. Turco, M. Pirro, M. Gargaro, G. Scalisi, F. Fallarino (Italy)

P1.28 AnalysisofBAFFandAPRILexpressioninmastcells:novelactorsintheB/MCcrosstalk A.A. Ceccaroni, F. Mion, I. Catacchio, V. Valeri, F. D’Incà, E. Betto, A. Tardivel*, P. Schneider*, A. Vacca, C.E.M. Pucillo (Italy, *Switzerland)

P2- ADAPTIVE IMMUNITY

P2.1 Presentationofbacterialandviralantigensbyantigen-presentingTcells:characterizationofT-APCscells V. Boccasavia, B. Alarcón (Spain)

P2.2 Characterization of the immunomodulatory activities of an Ascidian derived peptide in human PBMC A. Bonura, A. Vizzini, A. Longo, S. Vlah, F. Gervasi, M.R. Melis, P. Colombo (Italy)

P2.3 DifferentmodulationofpolyfunctionalCD8TcellresponsebycARTinprimaryandchronicHIVinfection R. Casetti, G. De Simone, C. Pinnetti, F. Besi, A. Sacchi, I. Abbate, G. Rozera, P. Pierro, C. Agrati, E. Cimini, V. Bordoni, N. Tumino, D. Viola, M.R. Capobianchi, A. Antinori, F. Martini, A. Ammassari (Italy)

P2.4 Chitinase3-Like-1isproducedbyhumanTh17cells A. Mazzoni, L. Maggi, V. Santarlasci, M. Capone, M.C. Rossi, G. Montaini, R. Cimaz, R. De Palma, E. Maggi,

POSTER SESSIONS

16


S. Romagnani, F. Liotta, L. Cosmi, F. Annunziato (Italy)

P2.5 Th1-inducedCD106expressionmediatesleukocytesadhesiononsynovialfibroblastsfromjuvenileidiopathicarthritispatients M.C. Rossi, L. Maggi, F. Margheri, C. Luciani, M. Capone, V. Santarlasci, A. Mazzoni, G. Montaini, R. Cimaz, F. Liotta, E. Maggi, L. Cosmi, M. Del Rosso, F. Annunziato (Italy)

P3 - IMMUNIDEFICIENCY

P3.1 Th1andTh17pro-inflammatoryprofilescharacterizeinvariantNKTcellsinvirologicallysuppressedHIV+patientswithlowCD4/CD8ratio E. Bianchini, S. De Biasi, M. Nasi, M. Digaetano, L. Gibellini, V. Borghi, M. Pinti, C. Mussini, A. Cossarizza (Italy)

P3.2 CD34+hematopoieticprogenitorcellsfromHIV-infectedpatientsshowanimpairedTcelldifferentiationinvitro,relatedtoautocrinepro-inflammatorycytokinesreleaseandTLR8triggering V. Bordoni, M. Bibas, D. Viola, A. Sacchi, C. Agrati, N. Tumino, E. Cimini, R. Casetti, A. Amendola, A. Ammassari, F. Martini (Italy)

P3.3 ImpactofARTonCD4+andCD8+T-cell-specificresponsetocommoncopathogensinHIV-TBcoinfectedsubjects T. Chiacchio, E. Petruccioli, V. Vanini, G. Cuzzi, C. Pinnetti, A. Sampaolesi, A. Antinori, F. Palmieri, E. Girardi, D. Goletti (Italy)

P3.4 CD4+naïveTcellsfromHIVpatientswithsuppressedviremiacontainlessproviralDNAandmoresjTREC+cellscompared to central or effector memory lymphocytes M. Nasi, S. De Biasi, E. Bianchini, M. Digaetano, S. Pecorini, M. Pinti, L. Gibellini, V. Borghi, C. Mussini, A. Cossarizza (Italy)

P3.5 Self-administeredhyaluronidasefacilitatedsubcutaneousimmunoglobulintherapyinsevereprimaryantibodydeficiencies F. Pulvirenti, M.G. Danieli, R. Morariu, V. Rocchi, C. Milito, I. Quinti (Italy)

P4 - IMMUNOREGULATION

P4.1 Bone-marrow-residentCD34+DNAM-1brightCXCR4+committedlymphoidprecursorsduringchronicinfectionandinflammationsupportsinnateandadaptiveimmuneresponses F. Bozzano, F. Marras, M.L. Ascierto*, C. Cantoni, G. Cenderello, C. Dentone, A. Di Biagio, G. Orofino, E. Mantia, S. Boni, P. De Leo, A. Picciotto, F. Braido, F. Antonini, E. Wang*, F. Marincola*, L. Moretta, A. De Maria (Italy, *USA,**Qatar)

P4.2 Casereport:effectivetreatmentofhypeRIgDsyndromewiththeinhibitionoftheenzymeHMG-CoAreductase E. Cillari, M.S. Leto Barone, F. Arcoleo, M. Lo Pizzo (Italy)

P4.3 Diet-relatedinflammationandimmunedysfunctioninobesity:potentialriskfactorsforcolorectalcancer G. Donninelli, M. D’Archivio, L. Conti, M. Del Cornò, B. Scazzocchio, R. Varì, B. Varano, S. Giammarioli, M. Pierdominici, R. Masella, S. Gessani (Italy)

P4.4 IL-27mediatestheexpressionofIDOandPD-L1inhumantumorcellsthroughSTAT1/3signaling G. Carbotti, G. Barisione, I. Airoldi, D. Mezzanzanica, A. Petretto, M. Fabbi, S. Ferrini (Italy)

P4.5 ICOS-ligandtriggeringimpairsosteoclastdifferentiationinvitroandinvivo C.L. Gigliotti, E. Boggio, N. Clemente, E. Toth, A. Chiocchetti, C. Dianzani, M. Bosetti, U. Dianzani (Italy)

P4.6 Theinvitroanti-inflammatoryandanti-toxiceffectsofnutraceuticals A. Giovazzino, A. Di Cerbo, G. Guidetti, V. Rubino, A.T. Palatucci, S. Centenaro, E. Fraccaroli, L. Cortese, G. Ruggiero, S. Canello, G. Terrazzano (Italy)

P4.7 A novel immunotherapy for heart failure M. Kallikourdis, E. Martini, P. Carullo, C. Sardi, C. Greco, G.G. Stirparo, G. Roselli, F. Riva, A. Ormbostad Berre*, T.O. Stølen*, G. Faggian, E. Di Pasquale, L. Elia, C. Rumio, D. Catalucci, R. Papait, G. Condorelli (Italy,*Norway)

POSTER SESSIONS

17


P4.8 HumanamnioticmesenchymaltissuecellsaffectbothM1andM2macrophagesinvitro M. Magatti, E. Vertua, S. De Munari, A. Silini, O. Parolini (Italy)

P4.9 Immunotherapies for cardiovascular diseases E. Martini, P. Carullo, C. Sardi, G. Roselli, G.G. Stirparo, F. Bonacina, D. Vignali, F. Riva, A.M. Ormbostad Berre*, T.O. Stølen*, G. Faggian, C. Rumio, E. Di Pasquale, G.D. Norata, L. Elia, R. Papait, D. Catalucci, G. Condorelli, M. Kallikourdis (Italy, *Norway)

P4.10 CD3+CD56+cells,anovelregulatorysubsetthatmodulatestheeffectorfunctionofhumanCD8+Tcells V. Rubino, M. Santopaolo, A. Giovazzino, A.T. Palatucci, C. La Rocca, E. Mozzillo, S. De Simone, A. Franzese, G. Matarese, G. Ruggiero, M. Galgani, G. Terrazzano (Italy)

P4.11 Myeloid derived suppressor cells increase during the early phases of primary HIV infection N. Tumino, F. Turchi, C. Pinnetti, R. Casetti, V. Bordoni, E. Cimini, C. Agrati, A. Antinori, A. Ammassari, F. Martini, A. Sacchi (Italy)

P4.12 InHIV-positivepatients,myeloid-derivedsuppressorcellsinduceT-cellanergybysuppressingCD3zetaexpressionthroughELF-1inhibition N. Tumino, F. Turchi, S. Meschi, E. Lalle, V. Bordoni, R. Casetti, C. Agrati, E. Cimini, C. Montesano, V. Colizzi, F. Martini, A. Sacchi (Italy)

P5 - NEUROIMMUNOLOGY

P5.1 Increasedadipokineslevelsinnormal-weightmultiplesclerosispatients M. Reale, E. Costantini, C. D’Angelo, L. Pasquali (Italy)

POSTER AREA POSTER SESSION II - FRIDAY 27 MAY - SATURDAY 28 MAY

P6 - AUTOIMMUNITY AND TOLERANCE

P6.1 Anti-tumournecrosisfactor-αdrugsdifferentlyaffecttumournecrosisfactor-α/solubletumournecrosisfactor-receptorsystem and monocyte subsets in patients with psoriasis E. Bianchini, L. Gibellini, S. De Biasi, R. Bartolomeo, A. Fabiano, M. Manfredini, F. Ferrari, G. Albertini, T. Trenti, G. Carnevale, M. Nasi, M. Pinti, G. Pellacani, A. Cossarizza (Italy)

P6.2 ClinicalphenotypemodificationaftertreatmentwithsofosbuvirintwopatientswithhepatitisCvirus-relatedmixedcryoglobulinemia: a monocentric experience R. Capecchi, G. Di Colo, F. Petrelli, P. Colombatto, M.R. Brunetto, P. Migliorini, A.G. Tavoni (Italy)

P6.3 SerumlevelsofCXCL13refinethepredictiveabilityofautoantibodiestoidentifyunstableremissioninearlyrheumatoidarthritis A. Manzo, S. Bugatti, B. Vitolo, F. Benaglio, R. Caporali, C. Montecucco (Italy)

P6.4 ShortglutenchallengewithwheatflourextensivehydrolyzedbyLactobacilli and Fungal proteases does not recall gliadinspecificT-cellsintheperipheralbloodofceliacdiseasepatients S. Picascia, R. Mandile, C. Parrella, L. Greco, M. Gobbetti, R. Auricchio, C. Gianfrani (Italy)

P6.5 TheancientwheatspeciesTriticum monococcum has a reduced in vivo immunotoxicity: implication for celiac disease prevention S. Picascia, A. Camarca, R. Auricchio, S. Vitale, R. Mandile, R. Troncone, S. Auricchio, G. Mamone, C. Gianfrani (Italy)

P6.6 ExpressionanalysisofHLAallelesassociatedtotype1diabetes L. Pisapia, A. Zimbardo, S. Picascia, P. Barba, M. Strazzullo, E. Mozzillo, A. Franzese, C. Gianfrani, G. Del Pozzo (Italy)

P6.7 TcellresponsetopeptidesoftheVregionofInfliximabisdetectableintreatedpatients S. Pratesi, F. Nencini, F. Zanieri, E. Maggi, A. Matucci, A. Vultaggio (Italy)

POSTER SESSIONS

18


P6.8 CirculatingTcellsubsetsincutaneouspsoriasis:correlationwithdiseaseseverityandsystemicinflammation F. Sgambelluri, M. Diani, A. Altomare, E. Frigerio, L. Drago, F. Granucci, G. Banfi, G. Altomare, E. Reali (Italy)

P6.9 InstallingFVIII-specifictoleranceInhemophiliaAviathearylhydrocarbonreceptoroperatedbytryptophanderivatives G. Scalisi, M. Gargaro, D. Matino, C. Santoro, M.G. Mazzucconi, P. Puccetti, A. Iorio, F. Fallarino (Italy)

P6.10 TheinterplaybetweenHLA-B*27andERAP1inankylosingspondylitis:afocusonprocessingandpresentationofunpredicted viral epitopes C. Vitulano, V. Tedeschi, F. Paladini, A. Cauli, A. Mathieu, R. Sorrentino, M.T. Fiorillo (Italy)

P7 - ONCO-HEMATOLOGY

P7.1 microRNAsprofileinbonemarrowfibroblastsfrompatientswithmultiplemyeloma L. Di Marzo, V. Desantis, I. Craparotta, L. Beltrame, S. Marchini, M. D’Incalci, A. Vacca, M.A. Frassanito (Italy)

P8 - TRANSPLANTATION

P8.1 5-azacytidineandrapamycin:differentandsynergisticeffectonexvivoexpansionofnaturalhumanTregulatorycells G. Conteduca, G. Ehx, M. Hannon, Y. Beguin, F. Baron (Belgium)

P9 - TUMOR IMMUNOLOGY

P9.1 Phenotypic and functional alterations in the T cell compartment of Diffuse Large B Cell Lymphoma (DLBCL) patients at diagnosis,andlong-termtherapy-inducemodifications S. Battella, M.C. Cox, R. La Scaleia, S. Pelliccia, A. Di Napoli, A. Porzia, F. Mainiero, L. Ruco, B. Monarca, A. Santoni, G. Palmieri (Italy)

P9.2 Lurbinectedinreducestumor-associatedmacrophagesandtheproductionofinflammatorycytokines,chemokinesandangiogenic factors in preclinical models C. Belgiovine, M. Liguori, E. Bello, R. Frapolli, C.M. Galmarini*, M. D’Incalci, P. Allavena (Italy,*Spain)

P9.3 HarnessingCD1c-restrictedTcellsfortheimmunotherapyofleukemia M. Consonni, C. Garavaglia, C. de Lalla, I. Boemi, M. Lepore*, G. De Libero*, L. Mori*, F. Ciceri, P. Dellabona, G. Casorati (Italy, *Switzerland)

P9.4 AnalysisofnaturalkillercellresponseinperipheralbloodofstageIIandIIImelanomapatients C.M. Cristiani, R. Tallerico, M. Capone, G. Madonna, D. Mallardo, C. Garofalo, E. Palella, E. Simeone, A.M. Grimaldi, G. Del Zotto, A. Moretta, P.A. Ascierto, E. Carbone (Italy)

P9.5 InvariantnaturalkillerTcellscontrolcancerprogressionbyrestrainingpro-angiogenictumorinfiltratingmacrophages F. Cortesi, G. Delfanti, A. Calcinotto, F. Gorini, F. Pucci*, M. Grioni, M. De Palma**, M. Bellone, G. Casorati, P. Dellabona (Italy, *USA, **Switzerland)

P9.6 Mastcell-derivedexosomespromotecoloncancercellproliferation F. D’Incà, F. Mion, B. Frossi, C. Pucillo (Italy)

P9.7 Highplasmalevelsofinterleukin-31andthymicstromallymphopoietinareassociatedwithclinicalcharacteristicofprognosticrelevanceinpatientswithclassicalHodgkin’slymphoma E. Ferretti, S. Hohaus, B. Belmonte, A. Di Napoli, E. Cupelli, E. Galli, A. Cuccaro, G. Fraternali-Orcioni, V. Pistoia, A. Corcione (Italy)

P9.8 Humanprimarycelllinesfromtumorandnon-tumortissueforthestudyofcolorectalcancerimmunity D. Gallerano, E. Timperi, C. Focaccetti, L. Sacco, F. Lancellotti, K. Fazzi, E. Manzi, M.G. Diodoro, S. Brozzetti, G.L. Grazi, P. Chirletti, V. Barnaba (Italy)

POSTER SESSIONS

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P9.9 WakingupNKcellsrecognitionofhumantumorcellsbynanoparticlesassisteddeliveryofsmalldrugsreactivatingP53 C. Garofalo, E. Palella, R. Tallerico, C.M. Cristiani, R. Sottile*, G. Selivanova*, E. Carbone (Italy, *Sweden)

P9.10 Occurrenceandsignificanceoftumor-associatedneutrophilsinpatientswithcolorectalcancer M.R. Galdiero, P. Bianchi, F. Grizzi, G. Di Caro, G. Basso, A. Ponzetta, E. Bonavita, M. Barbagallo, S. Tartari, N. Polentarutti, A. Malesci, G. Marone, M. Roncalli, L. Laghi, C. Garlanda, A. Mantovani, S. Jaillon (Italy)

P9.11 CD8Tcellregulationbybonemarrowendothelialcellsinmultiplemyeloma P. Leone, A. Ferrucci, I. Catacchio, V. Racanelli, A. Vacca (Italy)

P9.12 Role of complement in murine cancer development and its translational relevance E. Magrini, S. Di Marco, E. Bonavita, S. Gentile, M.L. Barbagallo, A. Ponzetta, A. Mantovani, C. Garlanda (Italy)

P9.13 PVR expression in multiple myeloma cells is regulated by sumoylation R. Molfetta, B. Zitti, L. Quatrini, C. Fionda, H. Stabile, V. de Turris, M.R. Ricciardi, M.T. Petrucci, M. Cippitelli, A. Gismondi, A. Santoni, R. Paolini (Italy)

P9.14 Elevated expression of mTGFβ on Treg cells in men with early diagnosed prostatic cancer S. Occhipinti, E. Lombardi, A. Zitella, P. Gontero, M. Giovarelli (Italy)

P9.15 Myeloid-derivedsuppressorcell-activatedTcellinteraction:mechanismsunderlyingimmunosuppression L. Pinton, S. Solito, E. Masetto, M. Vettore, V. Damuzzo, S. Francescato, A. Pozzuoli, A. Berizzi, S. Mocellin, C.R. Rossi, P. Zanovello, V. Bronte, S. Mandruzzato (Italy)

P9.16 IL-17inhibitionimprovestheantigen-specificanti-tumorresponsesinducedbyDNAvaccinationinpancreaticcancer C. Roux, R. Curto, G. Mucciolo, G. Barutello, F. Novelli, P. Cappello (Italy)

P9.17 Comparativetranscriptomicsoftriplenegativebreastcancerstemcellsanddifferentiatedtumorcellsidentifiesteneurin-4asapotentialtargetforimmunotherapy R. Ruiu, M. Arigoni, F. Riccardo, L. Conti, S. Lanzardo, C. Musiu, R.A. Calogero, F. Cavallo (Italy)

P9.18 RegulatoryTcellsshowingphenotypical,epigeneticandfunctionalfeaturesofimmunesuppressionareenrichedinhuman colorectal cancer E. Timperi, I. Pacella, V. Schinzari, L. Sacco, F. Farelli, F. Longo, A. Ciardi, P. Chirletti, V. Barnaba, S. Piconese (Italy)

P9.19 Naturalkillercellsfrompatientswitheithermalignantorinflammatorypleuraleffusionsdisplaydecreasedcytotoxiccapacityanddecidual-likephenotype S. Zanellato, A. Musco, A. Bruno, B. Bassani, M. Cattoni, C. Sampietro, A. Imperatori, A. Albini, D.D.M. Noonan, L. Mortara (Italy)

P9.20 TheMICA-129dimorphismandsolubleMICAareassociatedwiththeprogressionofmultiplemyeloma A. Zingoni, F. Cecere, D. Fuerst*, T. Saribekyan*, I. Nardone, E. Vulpis, M.P. Abruzzese, M.T. Petrucci, E. Lisi, M.R. Ricciardi, A. Soriani, C. Fionda, M. Cippitelli, A. Santoni (Italy, *Germany)

P10 - ALLERGIC INFLAMMATION

P10.1 RoleofnuclearfactorofactivatedTcells(NFAT)pathwayactivationininnateimmunecellsinacutetransplantrejection C. Cigni, F. Mingozzi, R. Marzi, M. Colombo, D. Prosperi, I. Zanoni*, F. Granucci (Italy, USA)

P11 - VACCINES AND IMMUNOTHERAPY

P11.1 Maternal immunization delays tumor progression in offspring prone to neuroblastoma G. Barutello, C. Voena, F. Riccardo, L. Consolino, R. Chiarle, F. Cavallo (Italy)

P11.2 ImmunosuppressiveactivityofabataceptoncirculatingThelperlymphocytesfromjuvenileidiopathicarthritispatients M. Capone, L. Maggi, R. Cimaz, V. Santarlasci, M.C. Rossi, A. Mazzoni, G. Montaini, F. Liotta, E. Maggi, F. Annunziato, L. Cosmi (Italy)

P11.3 Enhancingcytokine-inducedkillercellactivitywithHer2-specificFc-engineeredantibodiesandantibodyderivatives E. Cappuzzello, C. Kellner*, A. Rosato, M. Peipp* (Italy, *Germany)

POSTER SESSIONS

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P11.4 VaccinatingagainstHER2-positivebreastcancerwithanewnaturalpolymeractingasaTLRagonist D. Carpanese, I.M. Montagner, A. Dalla Pietà, G. Pasut, A. Mero, P. Zanovello, A. Rosato (Italy)

P11.5 Alum-TLR7enhancesexpansionofmemoryBcellcompartment T.M.H. Vo, S. Sammicheli, M. Tortoli, F. Corrente, M. Iannacone, U. D’Oro, D. Piccioli (Italy)

P11.6 NaturalpolymerX:anoveladjuvanttoexplorenewvaccinationstrategies I.M. Montagner, A. Dalla Pietà, D. Carpanese, G. Pasut, A. Mero, P. Zanovello, A. Rosato (Italy)

P11.7 “T cell interrogation system”: validation of immunogenic cell death and discovery of lung tumor antigens C. Focaccetti, A. Grimaldi, G. Peruzzi, G. Del Bene, S. Spada, F. Longo, P. Nisticò, V. Barnaba (Italy)

P11.8 Cytokineinducedkillercells(CIK)effectivelykillBRAFinhibitor-resistantmelanomacancerstemcells L. Gammaitoni, L. Giraudo, M. Macagno, V. Leuci, G. Mesiano, V. Coha, A. Zaccagna, A. Pisacane, S. Gallo, F. Carnevale-Schianca, M. Aglietta, D. Sangiolo (Italy)

P11.9 Chemotherapy enhances humoral and cellular responses against tumor associated antigens in pancreatic cancer G. Mandili, M. Principe, E. Mazza, S. Bulfamante, D. Giordano, P. Cappello, F. Novelli (Italy)

P11.10 ImmuneresponseinmiceimmunizedwithaClostridium perfringens beta2 recombinant toxin M. Pellegrini, A. Serroni, P. Pasquali, B. Chirullo, S. Corneli, K. Forti, L. Anzalone, G. Curina, M. Cagiola, A. De Giuseppe, G. Severi (Italy)

P11.11 Theinterplaybetweenanti-CD20therapeuticantibodiesandhumannaturalkillercells:impactofantibodyFcengeneering C. Pighi, C. Capuano, R. Molfetta, R. Paolini, A. Santoni, R. Galandrini (Italy)

P11.12 PreclinicalinvestigationoftherapeuticstrategiescombiningtumorvasculatureremodelingandGD2-CARTcellbasedimmunotherapy for human neuroblastoma P. Bocca, M. Cilli, L. Emionite, I. Caruana, B. De Angelis, C. Quintarelli, E. Di Carlo, A. Pezzolo, F. Morandi, F. Locatelli, V. Pistoia, I. Prigione (Italy)

P11.13 A chimeric DNA vaccine against CSPG4 for the treatment of malignant melanoma: an effective way to overcome immune tolerance in humans and dogs F. Riccardo, M. Arigoni, G. Barutello, V. Rolih, S. Occhipinti, E. Quaglino, G. Donofrio, S. Lanzardo, S. Mayayo, D. Giacobino, E. Lardone, S. Ferrone*, P. Buracco, F. Cavallo (Italy,*USA)

P11.14 Bovineherpesvirus4-basedvectorsencodingforchimericHER2antigeniseffectiveininducingapotentanti-tumorresponse against HER2+ mammary cancer V. Rolih, S. Jacca, V. Franceschi, E. Bolli, A. Ballatore, I.F. Merighi, G. Donofrio, F. Cavallo, E. Quaglino (Italy)

P11.15 Electro-gene-transfer:asolidplatformformonoclonalantibodygeneration E. Pavoni, A. Muzi, F.F. Ferrara, M. Cappelletti, E. Marra, G. Ciliberto, L. Aurisicchio, G. Roscilli (Italy)

P11.16 Immunomonitoringpredictisclinicaloutcomesofmelanomapatientsreceivingipilimumab S. Solito, V. Damuzzo, L. Pinton, S. Valpione, J. Pigozzo, V. Chiarion-Sileni, E. Carrozzo, R. Arboretti Giancristofaro, S. Mandruzzato (Italy)

P11.17 AnalysisofnaturalkillerandTcellsubsetsandtheirprognosticvalueinmelanomapatientstreatedwithIpilimumab(anti-CTLA-4) R. Tallerico, C.M. Cristiani, E. Staaf*, C. Garofalo, E. Palella, M. Capone, Y. Pico de Coaña*, G. Madonna, R. Sottile*, D. Mallardo, V. Carannante*, E. Simeone, A.M. Grimaldi, S. Johansson*, E. Gulletta, A. Anichini, F. Colucci, G. Ciliberto, R. Kiessling*, K. Kärre*, P.A. Ascierto, E. Carbone (Italy, Sweden)

Documents

National Congress of the Italian Society of Immunology ... · Italian Society of Immunology, Clinical Immunology ... the Italian Society of Immunology, Clinical Immunology and Allergology