Modeling Platform for CollaborationZheng Li

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TERANODE Modeling Platform

• TERANODE Design

Suite– Biological Modeler

– Protocol Modeler

– Protocol Player

– Closed-loop Edition

– Starter Edition (free)

• TERANODE Model

Server

• SDK

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Teranode History

Incorporated in Seattle, WA (June)DARPA, NSF, NIH, Intel research funding

Technology Transfer Complete

NIH Grant Awarded ($1.8M over 3yrs)3 Teranode Patents Pending

Closed Series A Production Clients V1 Released (Feb)

First Production Sites

V2 Launch (Oct)“ Top 100 Innovators” award2004

2003

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Q3Q3Q3Q3

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Q2Q2Q2Q2

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Q3Q3Q3Q3 Signed First Pilot Customer

2005

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V2.5 Launch (Jan)

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The Challenge

• Closed-loop R&D requires • flexibility and Scalability

Flexibility Scalability

DocumentsDesktop apps

DatabasesCustom apps

Existing options force users and managers

to choose

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Our Approach

Modeling provides both

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Informatics Choices:Databases, Documents, and Models

DynamicStatic

1,000’s ofData Points

Millions ofData Points

DATA REQUIREMENTS

SCALE

Documents

Error-proneTime-consumingLimited Reuse

LIMS/DatabasesExpensive ProgrammingLong Deployment Cycles

Poor Data Mobility

ModelsProgramming-free

Common Data PlatformData MobilityCost-effective

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Analytics

Lab Equipmentand Systems

System BiologyRepositories

SampleManagement

PathwayAnalytics

ReagentProduction

TERANODESolutions

TERANODE Offering

TERANODEDesign Suite

TERANODEModel Server

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Data Bottlenecks with Current LIMS

Delayed ResultsFragmentation

Data Must Be Imported and ExportedBetween Multiple Systems and Applications

Bottleneck Impact

Slow and CostlyDevelopment

ProgrammingChanging Data Requirements ofProtocols Requires Programming

LimitedCollaboration

CentralizationData Access and Sharing Requires

Database Connection

Siloed SystemsRigidity

Required Schema StandardizationLimits Broad Deployments

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Model-Driven LIMS with Teranode

Real-TimeDecision Support

Protocol ModelsAutomation of Data Management,

Integration, and Analytics

Solution Benefit

RapidDevelopment

Protocol ModelerVisual Protocol Designs by Scientists

Captured as Models

Common PlatformProtocol PlayerDesign Independent Automation

AnywhereData Usage

VLXPortable Data Format Enabling Data

Mobility for Collaboration and Integration

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TERANODE Solution Screening Automation

• TERANODE Screening Automation– TERANODE Design Suite– TERANODE Model Server– Screening Models– Integration Libraries

• Benefit– Flexible assay design – Data automation– Real-time decision support– No programming required

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Challenge

Flexible Assay Design

Solution

Results

• Deployed solution in 7 days

• Provided unlimited assay design flexibility

• Automated statistical & regression analysis

• Enhanced project team collaboration

Develop a protein array solution that supports changing assay parameters and automates statistical and regression analysis

• TERANODE Design Suite

• Custom regression analysis tool

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Challenge

Data Automation

Solution

Results

• Deployed solution in 5 days

• Automated data processing and analysis

• Eliminated data processing errors

• Provided real-time assay results

Develop a chemical screening solution that automates data processing and IC50 determinations

• TERANODE Design Suite & Model Server

• MD Spectramax data importer tool

• Data dictionary

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Data ServicesData Flow, Storage, and Indexing

Model-Driven Informatics:VLX Models

VLX Model

Computation ServicesAnalytics and Simulations

Integration ServicesInterchange with Equipment and

External Systems

Compliance ServicesAudit Trail and Reporting

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SampleSampleMgmt.Mgmt.DiagnosticsDiagnostics

TargetTargetId.Id.

HTSHTSHitHit

TriageTriage

ProcessProcessScienceScience

AssayAssayDesignDesign

StudyStudyDesignDesign

PathwayPathwayAnalyticsAnalytics

ReagentReagentProd.Prod.

Versatility of TERANODE Platform

ReagentReagentProd.Prod.

PathwayPathwayAnalyticsAnalytics

HTSHTS

SampleSampleMgmt.Mgmt.

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Demo