Reactions 1496, p31 - 12 Apr 2014 MMR varicella zoster virus vaccine Skin rash in a child: case report A 12-year-old boy developed a skin rash following administration of MMR varicella zoster virus vaccine [route, dosage and outcome not stated]. The boy’s medical history included DiGeorge syndrome and juvenile idiopathic arthritis, which was treated with etanercept. He inadvertently received the MMR varicella zoster virus vaccine during a well-child visit. Ten days later, he was hospitalised with a 2-day history of fever, conjunctivitis, rash and sore throat. His mother held further doses of etanercept. Upon admission, physical examination revealed a blanching morbilliform rash on his face, ears, neck, chest, back and limbs. He also had mild conjunctivitis, palatal petechiae with posterior pharyngeal erythema and mild post auricular cervical lymphadenopathy. The boy began receiving aciclovir. Urine and skin samples were positive for measles virus, and were phylogenetically clustered as genotype A with Edmonston reference strain. He was diagnosed with vaccine-associated disease. Author comment: "We describe the first known case of measles vaccine-associated disease in a DiGeorge patient on tumor necrosis factor inhibitor therapy in which genotype A Edmonston vaccine strain virus was identified from skin scrapings of the patient’s rash." Iroh Tam P-Y, et al. Measles vaccine strain from the skin rash of a DiGeorge patient receiving tumor necrosis factor inhibitor. Pediatric Infectious Disease Journal 33: 117, No. 1, Jan 2014 - USA 803101574 1 Reactions 12 Apr 2014 No. 1496 0114-9954/14/1496-0001/$14.95 Adis © 2014 Springer International Publishing AG. All rights reserved

MMR varicella zoster virus vaccine

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Reactions 1496, p31 - 12 Apr 2014

MMR varicella zoster virus vaccine

Skin rash in a child: case reportA 12-year-old boy developed a skin rash following

administration of MMR varicella zoster virus vaccine [route,dosage and outcome not stated].

The boy’s medical history included DiGeorge syndrome andjuvenile idiopathic arthritis, which was treated withetanercept. He inadvertently received the MMR varicellazoster virus vaccine during a well-child visit. Ten days later, hewas hospitalised with a 2-day history of fever, conjunctivitis,rash and sore throat. His mother held further doses ofetanercept. Upon admission, physical examination revealed ablanching morbilliform rash on his face, ears, neck, chest, backand limbs. He also had mild conjunctivitis, palatal petechiaewith posterior pharyngeal erythema and mild post auricularcervical lymphadenopathy.

The boy began receiving aciclovir. Urine and skin sampleswere positive for measles virus, and were phylogeneticallyclustered as genotype A with Edmonston reference strain. Hewas diagnosed with vaccine-associated disease.

Author comment: "We describe the first known case ofmeasles vaccine-associated disease in a DiGeorge patient ontumor necrosis factor inhibitor therapy in which genotype AEdmonston vaccine strain virus was identified from skinscrapings of the patient’s rash."Iroh Tam P-Y, et al. Measles vaccine strain from the skin rash of a DiGeorgepatient receiving tumor necrosis factor inhibitor. Pediatric Infectious DiseaseJournal 33: 117, No. 1, Jan 2014 - USA 803101574