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MINISTERO DELL'ISTRUZIONE, DELL'UNIVERSITÀ E DELLA RICERCA PROGETTO NEGOZIALE F.I.R.B. Identification and functional analysis of the gene expression profiles characterizing hormone- responsive breast cancer AIMS: 1. Identification of new panels of molecular markers to better prognostic evaluation of breast cancer lesions, with respect to prediction of the degree of hormone responsiveness and clinical evolution of the disease; 2. Generating a publicly available list of annotations on genes and gene networks relevant to mammary gland and breast cancer biology and to ovarian hormone action; 3. Training in post-genomics and technological dissemination.

MINISTERO DELL'ISTRUZIONE, DELL'UNIVERSITÀ E DELLA RICERCA P ROGETTO NEGOZIALE F.I.R.B. Identification and functional analysis of the gene expression profiles

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Page 1: MINISTERO DELL'ISTRUZIONE, DELL'UNIVERSITÀ E DELLA RICERCA P ROGETTO NEGOZIALE F.I.R.B. Identification and functional analysis of the gene expression profiles

MINISTERO DELL'ISTRUZIONE, DELL'UNIVERSITÀ E DELLA RICERCA

PROGETTO NEGOZIALE F.I.R.B.

Identification and functional analysis of the gene expression profiles characterizing hormone-responsive

breast cancer

AIMS:1. Identification of new panels of molecular

markers to better prognostic evaluation of breast cancer lesions, with respect to prediction of the degree of hormone responsiveness and clinical evolution of the disease;

2. Generating a publicly available list of annotations on genes and gene networks relevant to mammary gland and breast cancer biology and to ovarian hormone action;

3. Training in post-genomics and technological dissemination.

Page 2: MINISTERO DELL'ISTRUZIONE, DELL'UNIVERSITÀ E DELLA RICERCA P ROGETTO NEGOZIALE F.I.R.B. Identification and functional analysis of the gene expression profiles

MINISTERO DELL'ISTRUZIONE, DELL'UNIVERSITÀ E DELLA RICERCA

PROGETTO NEGOZIALE F.I.R.B.

Identification and functional analysis of the gene expression profiles characterizing hormone-responsive

breast cancer

AIMS:1. Identification of new panels of molecular

markers to better prognostic evaluation of breast cancer lesions, with respect to prediction of the degree of hormone responsiveness and clinical evolution of the disease;

2. Generating a publicly available list of annotations on genes and gene networks relevant to mammary gland and breast cancer biology and to ovarian hormone action;

3. Training in post-genomics and technological dissemination.

Page 3: MINISTERO DELL'ISTRUZIONE, DELL'UNIVERSITÀ E DELLA RICERCA P ROGETTO NEGOZIALE F.I.R.B. Identification and functional analysis of the gene expression profiles

MINISTERO DELL'ISTRUZIONE, DELL'UNIVERSITÀ E DELLA RICERCA

PROGETTO NEGOZIALE F.I.R.B.

Identification and functional analysis of the gene expression profiles characterizing hormone-responsive

breast cancer

AIMS:1. Identification of new panels of molecular

markers to better prognostic evaluation of breast cancer lesions, with respect to prediction of the degree of hormone responsiveness and clinical evolution of the disease;

2. Generating a publicly available list of annotations on genes and gene networks relevant to mammary gland and breast cancer biology and to ovarian hormone action;

3. Training in post-genomics and technological dissemination.

Page 4: MINISTERO DELL'ISTRUZIONE, DELL'UNIVERSITÀ E DELLA RICERCA P ROGETTO NEGOZIALE F.I.R.B. Identification and functional analysis of the gene expression profiles

MINISTERO DELL'ISTRUZIONE, DELL'UNIVERSITÀ E DELLA RICERCA

PROGETTO NEGOZIALE F.I.R.B.

Identification and functional analysis of the gene expression profiles characterizing hormone-responsive

breast cancer

AIMS:1. Identification of new panels of molecular

markers to better prognostic evaluation of breast cancer lesions, with respect to prediction of the degree of hormone responsiveness and clinical evolution of the disease;

2. Generating a publicly available list of annotations on genes and gene networks relevant to mammary gland and breast cancer biology and to ovarian hormone action;

3. Training in post-genomics and technological dissemination.

Page 5: MINISTERO DELL'ISTRUZIONE, DELL'UNIVERSITÀ E DELLA RICERCA P ROGETTO NEGOZIALE F.I.R.B. Identification and functional analysis of the gene expression profiles

Work Packages breakdown:

Workpackage 4• Activity 1-5: Cellular modelsCoordination: Second Univ. Napoli

Workpackage 2• Activity 1-4: Proteomics•Coordination: ISA-Natl Res. Council

Workpackage 3Activity 1: Animal modelsCoordination: Univ. Milano

Workpackage 4• Activity 1-3: Tumor profiling and clinical studiesCoordination: Univ. Torino

Workpackage 5• Activity 1-4: BioiformaticsCoordination: Second Univ. Napoli

Identification and functional analysis of the gene expression profiles characterizing hormone-responsive breast cancer

Page 6: MINISTERO DELL'ISTRUZIONE, DELL'UNIVERSITÀ E DELLA RICERCA P ROGETTO NEGOZIALE F.I.R.B. Identification and functional analysis of the gene expression profiles

Clinical data

(hormone responsiveness)

Identification and functional analysis of the gene expression profiles characterizing hormone-responsive breast cancer

MOLECULAR PROFILING

gene expression profiling of tumor samples

FUNCTIONAL CHARACTERIZATION

functional genomic and proteomic analyses in experimental models

VALIDATION

‘in situ’ analyses (tissue arrays and LCM)

Page 7: MINISTERO DELL'ISTRUZIONE, DELL'UNIVERSITÀ E DELLA RICERCA P ROGETTO NEGOZIALE F.I.R.B. Identification and functional analysis of the gene expression profiles

Identification and functional analysis of the gene expression profiles characterizing hormone-responsive breast cancer

FUNCTIONAL CHARACTERIZATION

MOLECULAR PROFILING

gene expression profiling of tumor samples

functional genomic and proteomic analyses in experimental models

‘in situ’ analyses (tissue arrays and LCM)

clinical studies

UniNa2IRCC-ToUniToIEO-MiUniFeIDI-RmUniMi (in vivo)

IST-Ge (in vivo)

ISA-CNR (proteomics)

IRCC-ToUniFeUniNa2ISA-CNR (proteomics)

UniFeIRCC-ToUniNa2

UniFeIRCC-To

BIOINFORMATICS

UniNa2 ISA-CNR IST-Ge IEO-MiUniTo IRCC-ToCINECA-Bo UniFe

VALIDATION

Page 8: MINISTERO DELL'ISTRUZIONE, DELL'UNIVERSITÀ E DELLA RICERCA P ROGETTO NEGOZIALE F.I.R.B. Identification and functional analysis of the gene expression profiles

Identification and functional analysis of the gene expression profiles characterizing hormone-responsive breast cancer

http://www.hrbc-genomics.net/

Alessandro WeiszDipartimento di Patologia generale

Seconda Università degli Studi di Napoli

[email protected]