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Nervous System II
Meninges• membranes surrounding CNS• protect CNS• three layers
• dura mater – outer, tough• arachnoid mater - weblike• pia mater – inner, delicate
Meninges of the Spinal Cord
Ventricles• interconnected cavities• within cerebral hemispheres and brain stem• continuous with central canal of spinal cord• filled with cerebrospinal fluid (csf)
• lateral ventricles• third ventricle• fourth ventricle• cerebral aqueduct
Cerebrospinal Fluid
• secreted by choroid plexus• circulates in ventricles, central canal of spinal cord, and subarachnoid space• completely surrounds brain and spinal cord• clear liquid• nutritive and protective• helps maintain stable ion concentrations in CNS
Spinal Cord Structure• extends foramen magnum to 2nd lumbar vertebra
Cross Section of Spinal Cord
Spinal Cord Functions
• center for spinal reflexes
• conduit for nerve impulses to and from the brain
Reflex ArcsReflexes – automatic, subconscious responses to stimuli
Knee-jerk Reflex• helps maintain posture
Withdrawal Reflex• protective
Crossed-Extensor Reflex
• flexor muscles contract• flexor muscles on opposite side inhibited• extensor muscles on opposite side contract for balance
Tracts of the Spinal Cord
• Ascending tracts conduct sensory impulses to the brain• Descending tracts conduct motor impulses from the brain to motor neurons reaching muscles and glands
Ascending Tracts• fasciculus cuneatus• lateral spinothalamic
Corticospinal Tract
Brain
Functions• interprets sensations• determines perception• stores memory• reasoning• makes decisions• coordinates muscular movements• regulates visceral activities• determines personality
Major Parts• cerebrum
• two cerebellar hemispheres• diencephalon• brain stem• cerebellum
Brain Development
Three Major Vesicles1. Forebrain2. Midbrain3. Hindbrain
Forebrain (prosencephalon)• anterior portion (telencephalon)
• cerebrum• basal ganglia
• posterior portion (diencephalon)• thalamus• hypothalamus• posterior pituitary• pineal gland
Brain Development
Midbrain (mesencephalon)
• midbrain
Hindbrain (rhombencephalon)• anterior portion (metencephalon)
• cerebellum• pons
• posterior portion (myelencephalon)• medulla oblongata
Structure of Cerebrum
• corpus callosum• connects hemispheres
• convolutions • bumps or gyri
• sulci• grooves
• longitudinal fissure• separates hemispheres
• transverse fissure• separates cerebrum from cerebellum
Lobes of Cerebrum
• Frontal• Parietal• Temporal• Occipital• Insula
Functions of Cerebrum
• interpretation• initiating voluntary movements• storing memory• retrieving memory• reasoning• center for intelligence and personality
Functional Regions of Cerebral Cortex
Cerebral Cortex – thin layer of gray matter that constitutes the outermost portion of cerebrum; contains 75% of all neurons in nervous system
Motor Areas• Primary Motor Areas
• frontal lobes• control voluntary muscles
• Broca’s Area• anterior to primary motor cortex• usually in one hemisphere• controls muscles needed for speech
• Frontal Eye Field• above Broca’s area• controls voluntary movements of eyes and eyelids
Motor Areas
Sensory Areas
• Cutaneous Sensory Area
• parietal lobe• interprets sensations on skin
• Visual Area• occipital lobe• interprets vision
• Auditory Area• temporal lobe• interprets hearing
Sensory Areas
Association Areas• regions of cortex that are not primary motor or primary sensory areas• widespread throughout the cerebral cortex• analyze and interpret sensory experiences• provide memory, reasoning, verbalization, judgment, emotions
Association Areas
Frontal Lobe Association Areas• concentrating• planning• problem solving• judging
Parietal Lobe Association Areas• understanding speech• using words to express thought
Temporal Lobe Association Areas• remember visual scenes• remember music• remember complex patterns
Occipital Lobe Association Areas• combine visual images with other sensory experiences
Hemisphere Dominance
• In over 90% of population, left hemisphere is dominant
• Dominant hemisphere controls
• speech• writing• reading• verbal skills• analytical skills• computational skills
• Nondominant hemisphere controls
• nonverbal tasks• motor tasks• understanding and interpreting musical and visual patterns• provides emotional and intuitive thought processes
Memory
Short Term• working memory• closed circuit• circuit is stimulated over and over• when impulse flow stops, memory disappears
Long Term• changes structure and function of neurons• enhanced synaptic transmission
Basal Nuclei
• masses of gray matter• deep within cerebral hemispheres• caudate nucleus, putamen, globus pallidus• produce dopamine• control certain muscular activities
Diencephalon• between cerebral hemispheres and brainstem• surrounds third ventricle
• thalamus• hypothalamus• optic tracts• optic chiasm• infundibulum• posterior pituitary• mammillary bodies• pineal gland
Diencephalon
Thalamus• gateway for sensory impulses heading to cerebral cortex• receives all sensory impulses (except smell)• channels impulses to appropriate part of cerebral cortex for interpretation
Hypothalamus• maintains homeostasis by regulating visceral activities • links nervous and endocrine systems
Limbic System
Consists of• portions of frontal lobe• portions of temporal lobe• hypothalamus• thalamus• basal nuclei• other deep nuclei
Functions• controls emotions• produces feelings• interpret sensory impulses
Brain Stem
Three Parts1. Midbrain2. Pons3. Medulla Oblongata
Midbrain
• between diencephalon and pons• contains bundles of fibers that join lower parts of brainstem and spinal cord with higher part of brain• cerebral aqueduct• cerebral peduncles – bundles of nerve fibers• corpora quadrigemina – centers for visual and auditory reflexes
Pons
• rounded bulge on underside of brainstem• between medulla oblongata and midbrain• helps regulate rate and depth of breathing• relays nerve impulses to and from medulla oblongata and cerebellum
Medulla Oblongata
• enlarged continuation of spinal cord• conducts ascending and descending impulses between brain and spinal cord• contains cardiac, vasomotor, and respiratory control centers• contains various nonvital reflex control centers (coughing, sneezing, vomiting)
Reticular Formation
• complex network of nerve fibers scattered throughout the brain stem• extends into the diencephalon• connects to centers of hypothalamus, basal nuclei, cerebellum, and cerebrum• filters incoming sensory information • arouses cerebral cortex into state of wakefulness
Types of Sleep
Slow Wave• person is tired• decreasing activity of reticular system• restful• dreamless• reduced blood pressure and respiratory rate• ranges from light to heavy• alternates with REM sleep
Rapid Eye Movement (REM)• some areas of brain active• heart and respiratory rates irregular• dreaming occurs
Cerebellum
• inferior to occipital lobes• posterior to pons and medulla oblongata• two hemispheres• vermis connects hemispheres• cerebellar cortex – gray matter• arbor vitae – white matter• cerebellar peduncles – nerve fiber tracts• dentate nucleus – largest nucleus in cerebellum• integrates sensory information concerning position of body parts• coordinates skeletal muscle activity• maintains posture
Peripheral Nervous System
• Cranial nerves arising from the brain• Somatic fibers connecting to the skin and skeletal muscles• Autonomic fibers connecting to viscera
• Spinal nerves arising from the spinal cord• Somatic fibers connecting to the skin and skeletal muscles• Autonomic fibers connecting to viscera
Structure of a Peripheral Nerve
Nerve Fiber Classification
• Sensory Nerves – conduct impulses into CNS• Motor Nerves – conduct impulses to muscles or glands• Mixed Nerves – contain both sensory nerve fibers and motor nerve fibers; most nerves
General somatic efferent fibers• carry motor impulses from CNS to skeletal muscles
General visceral efferent fibers• carry motor impulses away from CNS to smooth muscles and glands
General somatic afferent fibers• carry sensory impulses to CNS from skin and skeletal muscles
General visceral afferent fibers• carry sensory impulses to CNS from blood vessels and internal organs
Nerve Fiber Classification
Special somatic efferent fibers• carry motor impulses from brain to muscles used in chewing, swallowing, speaking, and forming facial expressions
Special visceral afferent fibers• carry sensory impulses to brain from olfactory and taste receptors
Special somatic afferent fibers• carry sensory impulses to brain from receptors of sight, hearing, and equilibrium
Cranial Nerves
Cranial Nerves I and II
Olfactory (I)• sensory• fibers transmit impulses associated with smell
Optic (II)• sensory• fibers transmit impulses associated with vision
Cranial Nerves III and IV
Trochlear (IV)• primarily motor• motor impulses to muscles that move the eyes
Oculomotor (III)• primarily motor• motor impulses to muscles that
• raise eyelids• move the eyes• focus lens•adjust light entering eye
Cranial Nerve VTrigeminal (V)
• mixed• opthalmic division
• sensory from surface of eyes, tear glands, scalp, forehead, and upper eyelids
• maxillary division• sensory from upper teeth, upper gum, upper lip, palate, and skin of face
• mandibular division• sensory from scalp, skin of jaw, lower teeth, lower gum, and lower lip• motor to muscles of mastication and muscles in floor of mouth
Cranial Nerves VI and VIIAbducens (VI)
• primarily motor• motor impulses to muscles that move the eyes
Facial (VII)• mixed• sensory from taste receptors• motor to muscles of facial expression, tear glands, and salivary glands
Cranial Nerves VIII and IX
Vestibulocochlear (VIII)• sensory• sensory from equilibrium receptors of ear• sensory from hearing receptors
Glossopharyngeal (IX)• mixed• sensory from pharynx, tonsils, tongue, and carotid arteries• motor to salivary glands and muscles of pharynx
Cranial Nerve X
Vagus (X)• mixed• somatic motor to muscles of speech and swallowing• autonomic motor to viscera of thorax and abdomen• sensory from pharynx, larynx, esophagus, and viscera of thorax and abdomen
Cranial Nerves XI and XII
Accessory (XI)• primarily motor• motor to muscles of soft palate, pharynx, larynx, neck, and back
Hypoglossal (XII)• primarily motor• motor to muscles of the tongue
Spinal Nerves
• mixed nerves• 31 pairs
• 8 cervical (C1 to C8)• 12 thoracic (T1 to T12)• 5 lumbar (L1 to L5)• 5 sacral (S1 to S5)• 1 coccygeal (Co)
Spinal NervesDorsal root
• axons of sensory neurons in the dorsal root ganglion
Dorsal root ganglion • cell bodies of sensory neurons
Ventral root• axons of motor neurons whose cell bodies are in spinal cord
Spinal nerve• union of ventral root and dorsal root
Dermatome• an area of skin that the sensory nerve fibers of a particular spinal nerve innervate
Cervical Plexus
Nerve plexus – complex networks formed by anterior branches of spinal nerves; fibers of various spinal nerves are sorted and recombined
Cervical Plexus• C1-C4• lies deep in the neck• supply muscles and skin of the neck• contribute to phrenic nerve
Brachial Plexus• C5-T1• lies deep within shoulders• musculocutaneous nerves
• supply muscles of anterior arms and skin of forearms
• ulnar nerves• supply muscles of forearms and hands• supply skin of hands
• radial nerves• supply posterior muscles of arms and skin of forearms and hands
• axillary nerves• supply muscles and skin of superior, lateral, and posterior arms
Lumbosacral Plexus
• T12 – S5• extend from lumbar region into pelvic cavity• obturator nerves
• supply adductors of thighs
• femoral nerves• supply muscles and skin of thighs and legs
• sciatic nerves• supply muscles and skin of thighs, legs, and feet
Autonomic Nervous System
• functions without conscious effort• controls visceral activities• regulates smooth muscle, cardiac muscle, and glands• efferent fibers typically lead to ganglia outside CNS
Two Divisions• sympathetic – prepares body for fight or flight situations• parasympathetic – prepares body for resting and digesting activities
Autonomic Nerve Fibers
• all are motor (efferent)• preganglionic fibers
• axons of preganglionic neurons• neuron cell bodies in CNS
• postganglionic fibers• axons of postganglionic neurons• neuron cell bodies in ganglia
Sympathetic Division
• thoracolumbar divison – location of preganglionic neurons
• preganglionic fibers leave spinal nerves through white rami and enter paravertebral ganglia
• paraverterbral ganglia and fibers that connect them make up the sympathetic trunk
Sympathetic Division• postganglionic fibers extend from sympathetic ganglia to visceral organs
• postganglionic fibers usually pass through gray rami and return to a spinal nerve before proceeding to an effector
• preganglionic fibers to adrenal medulla do not synapse with postganglionic neurons
Sympathetic Division
Parasympathetic Division
• craniosacral division – location of preganglionic neurons
• ganglia are near or within various organs
• short postganlionic fibers
• preganglionic fibers of the head in III, VII, and IX
• preganglionic fibers of thorax and abdomen in X
Parasympathetic Division
Autonomic NeurotransmittersCholinergic Fibers
• release acetylcholine• preganglionic sympathetic fibers• preganglionic parasympathetic fibers• postganglionic parasympathetic fibers
Adrenergic Fibers• release norepinephrine• postganglionic sympathetic fibers
Actions of AutonomicNeurotransmitters
• depend on receptor
Cholinergic receptors• bind to acetlycholine• muscarinic
• excitatory • nicotinic
• excitatory
Adrenergic Receptors• bind to norepinephrine• alpha
• different responses on various effectors
• beta• different responses on various effectors
Insert figure 11.39Actions of Autonomic
Neurotransmitters
Control of Autonomic Activity
• Controlled largely by CNS• Medulla oblongata regulates cardiac, vasomotor and respiratory activities• Hypothalamus regulates visceral functions• Limbic system and cerebral cortex control emotional responses
Life-Span Changes
• Brain cells begin to die before birth• Over average lifetime, brain shrinks 10%• Most cell death occurs in temporal lobes• By age 90, frontal lobe has lost half its neurons• Number of dendritic branches decreases• Decreased levels of neurotransmitters• Fading memory• Slowed responses and reflexes• Changes increase risk of falling• Sleep problems common
Clinical ApplicationCerebral Injuries and Abnormalities
Concussion• brain jarred against cranium• loss of consciousness• temporary loss of memory• mental cloudiness• headache• recovery usually complete
Cerebral Palsy• motor impairment at birth• caused by blocked cerebral blood vessels during development• seizues• learning disabilities
Cerebrovascular Accident• stroke• sudden interruption in blood flow• brain tissues die
TABLES FOR CHAPTER 11