Microwave

Radiometry

Microwave

Radiometry

The RTM-01-RES radiometer receives and evaluates

the natural electromagnetic radiation (temperature)

from the patient’s internal tissues at microwave

frequencies

RTM – PrinciplesRTM – Principles

Temperature DistributionTemperature Distribution

Venous and ArterialVenous and ArterialBlood Blood TemperatureTemperature

Te

mp

era

ture

(oC

)

31

32

33

34

35

36

37

carcinomas of

upper outer quadrant

carcinomas of

upper outer quadrantcarcinomas of

inner quadrants

carcinomas of

inner quadrants

a b c d e f g h i j k

lateral thoracicvein ˜

artery š internal mammary

c

ancer

Growth Rate and Specific Heat Growth Rate and Specific Heat Production of Breast CarcinomasProduction of Breast Carcinomas

Metabolic Heat Production ofCancer Tissueq* (10-3 W/cm3)

Doubling Time of Tumor Volume (days)

10

70

20

30

40

50

60

0200 300 400 500 600 700100

WITHOUT lymph node metastases

WITHlymph node metastases

128 Breast Carcinomas T1 and T2

128 Breast Carcinomas T1 and T2

Heat transfer in mammary glandHeat transfer in mammary gland

Depth of penetration of tissueDepth of penetration of tissue

Conductivity of normalConductivity of normal and malignant tissuesand malignant tissues

Antennas` FieldAntennas` Field

Dx

Z

ENERGY %

Dx,cm

Dy,cm

Z,cm

V,cm3

20 1.45 1.2 0.8 1.4

30 1.7 1.6 1.2 2.6

40 2.1 2 1.6 4.5

50 2.5 2 2 7.1

60 3 2.4 2.4 10.6

70 3.4 2.8 3.2 21.2

80 3.8 3.2 4.3 43

90 4.2 4 6.2112.

3

95 4.5 4.8 8.4273.

7

RTM – 01 – RESRTM – 01 – RESImaging SystemImaging System

Items Specifications Thermal abnormality (i.e. a lower or higher temperature) is detected at a depth of, cm

3 ‑5 (depending on water content tissue type)

Accuracy of measuring the averaged internal temperature, when a temperature is 32 ‑ 38 C, C

0,2

Time required for measuring internal temperature at a point, seconds

6

Antenna diameter, mm 39

Accuracy of measuring the skin temperature, C 0,2

Time required for measuring skin temperature at a point, when the temperature is 32 ‑ 38 C, seconds

1

Device mass, kg 4

Power consumption, Watt 5

The efficacy of the method is confirmed by clinical trials, The efficacy of the method is confirmed by clinical trials,

which were carried out among more then 3500 patientswhich were carried out among more then 3500 patients

RTM - DiagnosisRTM - Diagnosis

Breast Temperature FieldBreast Temperature Field

Results of the measurements can be displayed in different modesResults of the measurements can be displayed in different modes

RTM-Diagnosis SoftwareRTM-Diagnosis Software

Data of the measured temperatures are automatically stored in the Data of the measured temperatures are automatically stored in the computers memory to be processed.computers memory to be processed.

• The green color represents the average The green color represents the average

temperature field of an examined organtemperature field of an examined organ

Right MG Left MG

Temperature(ºC): Minimum 32.8, Mean 33.8, Maximum 35.3

Isotherm step

Breast Temperature FieldBreast Temperature Field

The red color represents a high The red color represents a high

temperature field of an examined organtemperature field of an examined organ

Right MG Left MG

Temperature(ºC): Minimum 32.8, Mean 33.8, Maximum 35.3

Isotherm step

Breast Temperature FieldBreast Temperature Field

• The blue color represents a lower The blue color represents a lower

than average normal temperaturethan average normal temperature

Right MG Left MG

Temperature(ºC): Minimum 32.8, Mean 33.8, Maximum 35.3

Isotherm step

Breast Temperature FieldBreast Temperature Field

Example: This is the temperature field of a healthy Example: This is the temperature field of a healthy

woman’s breasts.woman’s breasts.

Temperature(ºC): Minimum 34.8, Mean 35.1, Maximum 35.4

Right MG Left MGIsotherm step

Healthy Woman’s FieldHealthy Woman’s Field

Many diseases (such as cancer) are represented by high Many diseases (such as cancer) are represented by high

temperature areas in the internal temperature field.temperature areas in the internal temperature field.

Temperature(ºC): Minimum 32.8, Mean 33.8, Maximum 35.3

Right MG Left MGIsotherm step

Breast Temperature FieldBreast Temperature Field

The software analyses whether an examined patient has The software analyses whether an examined patient has features of cancer.features of cancer.

Sign A Sign A Sign A

Sign ASign ASign A

Sig

n E

Sig

n F

Sig

n G

Sig

n B

Sig

n C

Sig

n D

Expert SystemExpert System

The results of the measurements may also be The results of the measurements may also be displayed as a thermogram. The fourth and the fifth displayed as a thermogram. The fourth and the fifth

points on the left breast are marked.points on the left breast are marked.

Thermogram - Diagnosis

right Mg

left Mg

Series 1

base point T1

base point T1

Series 2

Series 3

Conventional signs

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ThermogramThermogram

In this case there is an

extremely high possibility

that the examined patient

has left breast cancer

In this case there is an

extremely high possibility

that the examined patient

has left breast cancer

Right Breast Left BreastIsotherm step

Close object:

Mark 1 Mark 2

Sign A Sign A

Sign A Sign A Sign A

Sig

n B

Sig

n C

Sig

n D

Sig

n F

Sig

n G

Sig

n E

right Mg

left Mg

Series 1

base point T1

base point T2

Series 2

Series 3

Conventional signs

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• The RTM-01-RES is The RTM-01-RES is

indispensable for the indispensable for the

monitoring of treatment due monitoring of treatment due

to the fact that it is to the fact that it is

absolutely harmlessabsolutely harmless..

• This is a sample of the This is a sample of the positive dynamics which positive dynamics which

occur during the treatment of occur during the treatment of mastitis.mastitis.

Patient B. (after

treatment). Right Breast Left Breast

Patient B. (before

treatment). Right Breast Left Breast

Clinical diagnosis - both breasts have

diffuse fibrocystic mastopathy, node

neoplasm is not detected.

X-ray - fibrocystic mastopathy with

fibrous features.

Puncture - erythrocytes, fat drops.

During oncological During oncological

processes thermal processes thermal

changes precede changes precede

anatomical changes. anatomical changes.

The diagnostic method The diagnostic method

has a unique ability to has a unique ability to

detect cancer diseases detect cancer diseases

at early stages, when at early stages, when

the traditional methods the traditional methods

can not detect can not detect

diseases, which have diseases, which have

just appeared.just appeared.

Patient K., 57 years old

Clinical Trials ResultsClinical Trials Results

89,694,2

85,190,3

86,490,4

77,6

8981,8

77,7 76,5 76

0

50

100

Russian OncologicalScientific Centre

Municipal ClinicalHospital #40

Brunch #1 ofMammology Health

Centre

Oncological HealthCentre of Moscow

HealthcareCommittee

Sensitivity Accuracy Specificity

Number of Patients – 771

CancerPatients – 101 (13%)

Number of Patients – 771

CancerPatients – 101 (13%)

Number of Patients – 43

CancerPatients – 35 (76%)

Number of Patients – 43

CancerPatients – 35 (76%)

Number of Patients – 81

CancerPatients – 48 (60%)

Number of Patients – 81

CancerPatients – 48 (60%)

Number of Patients – 81

CancerPatients – 48 (60%)

Number of Patients – 81

CancerPatients – 48 (60%)

№ Diameter (см) N %

Thermo positive

Thermo negative

Risk group

Uncertain conclusions

N N N % N % N %

1 No Tumors 29 9,2 19 65,5 6 20,7 4 13,8 0 0

2 Less 1,3 см 19 6 10 52,6 2 10,5 5 26,3 2 10,5

3 1,3 ≤D< 1,8 45 14,2 26 57,7 6 13,3 12 26,6 1 2,2

4 1,8 ≤D< 2,3 58 18,3 36 62,1 4 6,9 16 27,6 2 3,4

5 2,3 ≤D< 2,6 49 15,5 39 79,6 2 4,1 6 12,2 2 4,1

6 2,6 ≤D< 3,6 42 13,3 37 88,1 3 7,1 2 4,8 Нет 0

7 3,7 ≤D< 7 37 11,7 33 89,1 1 2,7 3 8,1 Нет 0

8 Infiltration Defuse Form 11 3,5 10 90,9 Нет 0 Нет 0 1 9,1

9 No information 26 8,2 22 84,6 2 7,7 2 7,7 Нет 0

Итого 316 100 232 73,4 2,6 8,2 50 15,8 8 2,5

RTM ResultsRTM Results