Microarray Principles & Applications

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Microarray Principles & Applications. Overview. Technology - Differences in platforms Utility & Applications - What will a microarray do for you? The Future of Microarrays – Where are they heading…. Assays Of Biological Variation. Genotype Analysis SNP Analysis Mutation Screening. - PowerPoint PPT Presentation

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  • MicroarrayPrinciples & Applications

  • OverviewTechnology - Differences in platformsUtility & Applications - What will a microarray do for you?The Future of Microarrays Where are they heading

  • Assays Of Biological VariationGenotype AnalysisSNP AnalysisMutation ScreeningProteomicsGene Expression Analysis

  • The Good Ol DaysSequencing GelsNorthernsWesterns

  • One Platform = Multiple ApplicationsGenotypingPharmacogeneticsDiagnosticsMultiplex-ELISADiagnosticsTox StudiesExpression dbMicroarrays

  • Microarray DevelopmentRelatively young technology

    Mainly used in gene discovery

    Widely adopted

  • Evolution & Industrialization1994- First cDNAs are developed at Stanford.1995- Quantitative Monitoring of Gene Expression Patterns with a Complementary DNA Microarray- Schena et. al.1996- Commercialization of arrays1996-Accessing Genetic Information with High Density DNA Arrays-Chee et. al.1997-Genome-wide Expression Monitoring in S. cerevisiae-Wodicka et. al.

  • TechnologyDefinitionMicroarray- A substrate with bound capture probesCapture probeAn oligonucleotide/DNA with gene/polymorphism of interestFabricationPhotolithography-AffymetrixPrinting-Incyte, GenometrixTarget GenerationOne colorTwo colorAnalysisScanning of arrayAmount of hybridized target is assessed.

  • Background of MicroarraysBasic Types of FabricationPhotolithographicAffymetrixOligonucleotide capture probeMechanical depositionIncyte, Molecular Dynamics, GenometrixcDNA or oligonucleotide capture probesInk jets, capillaries, tipsTarget PreparationRT of RNA to cDNARNA amplification

  • Array AdvantagesEfficient use of reagentsSmall volume depositionMinimal wasted materials

    High-throughput capabilityAssess many genes simultaneouslyExamine many samples quicklyCan be automated

  • ApplicationsDiscoveryLeadsPreClinicalClinicalTarget DiscoveryTarget ValidationScreeningValidationOptimizationToxicologyOptimizationGenotypingADE Screens

  • Applications in Drug DevelopmentSample ThroughputGenes Interrogated10000

    1000

    1010100010000LeadsDiscovery

    Pre-ClinicalClinical

  • Array TechnologyArray Design & FabricationDetermine genes to be analyzedDesign DNA reagents to be arrayedUse automated arraying instrument

  • Affymetrix Fabrication Process

  • cDNA Microarray FabricationUp to 10,000 elements per arrayElements 500 to 5000 bases in lengthProprietary surface chemistryReduced backgroundCleanroom fabrication facilityScalable operation

  • Oligonucleotide MicroarrayImmobilized gene specific oligo probes

    ACUGCUAGGUUAGCUAGUCUGGACAUUAGCCAUGCGGAUGCCAUGCCGCUU GACCTGTAATCGGTACGCCTA

  • Genometrix Array Printer Proprietary Delivery Mechanism Fully Automated Standard Format Compatible

  • VistaArray Microarrays Medium density-up to 250 elements Preselect genes based on high-density arrays Can be easily customized Cost effectiveHigh-throughput capabilityHundreds of samplesAutomatable

  • Probe LabelingOptimized one-step fluorescent labeling protocolNo amplification of RNAStarting material 200 ng of polyA mRNABuilt in controls for sensitivity, ratios and RT quality

  • Probe Labeling

  • Array TechnologySample PreparationIsolate cell, tissue, or DNA samplesGenerate labeled DNA or cDNA materialsSample HybridizationHybridize labeled sample to array

  • Microarray HybridizationTwo probe populations competitively hybridized1/100,000 sensitivity across most genes in 200 ng mRNARoutinely detects two-fold changes in expression

  • Array TechnologySample AnalysisCCD/ laser imagingRapid analysisHighly sensitiveFully automated

  • Image AnalysisElement regionsBackground Adjusted ElementsAuto-griddingEdge detectionNoise filtering

    Background subtractionAuto integration into database

  • ApplicationsGene Discovery-Assigning function to sequenceDiscovery of disease genes and drug targetsTarget validationGenotypingPatient stratification (pharmacogenomics)Adverse drug effects (ADE)Microbial ID

    The List Continues To Grow.

  • Profiling Gene ExpressionLungTumorLiverTumorKidneyTumor

  • Normal vs. Normal

  • Normal vs. Tumor

  • Lung Tumor: Up-Regulated

  • Lung Tumor: Down-Regulated

  • Lung Tumor: Up-RegulatedSignal transductionCytoskeletonProteases/InhibitorsKinases

  • Lung Tumor: Up-RegulatedSignal transductionCytoskeletonProteases/InhibitorsKinasesCyclin B1Cyclin-dependentkinaseTumor expression-related protein

  • Lung Tumor: Down-RegulatedSignal transductionCytoskeletonProteases/InhibitorsKinases

  • Lung Tumor: Down-RegulatedSignal transductionCytoskeletonProteases/InhibitorsKinasesTumor necrosisfactor-related protein

  • Genes Common to All 3 TumorsUp-regulatedDown-regulated

  • Microarrays and Lead Validation and OptimizationMay alleviate current bottlenecksHigh-throughputBiological relevance (e.g. primary cell lines)Validate more than one target per compoundEasy and quick assay to develop (no cell engineering)Generate toxicity data on compoundDatabase correlation to compound structureDetermine mode(s) of compound/target interaction. Broad functionality to a compound (e.g. ion channel mod, cell cycle regulator, membrane receptor)

  • Why would you screen more compounds?DiscoveryManufacturabilityLower toxicityBetter mode of applicationImproved efficacy

  • Optimization with ArraysExpression ProfileTarget

    Chart1

    50.2-0.53.72.44.93.8008.2-0.36.4-0.8-7.37.54.3-21.80.40.90.20.40.4-0.44.2-0.3-4.3-2.10.41.50.2-4.11.8-0.1-4.20-4.34.2-0.60.93.1-2.3-7.8-0.70.1-4.1-7.45.5-0.1-6.20.7-4.2-0.20.5-0.6-0.7-0.7-0.6-0.2-0.80.1-1.1-2.2-0.7-2.8-6.1-5.1-1-3.1TSATSA

    40.2-0.100.10.3-0.210.40.20.10-0.9-0.7-0.10.1-0.71.11.5-0.70.10.8-0.50.20.8-0.1-0.5-0.71.50.9-0.30.9-0.301-0.3-0.720.7-1.1-0.7-0.5-0.9-0.9-0.3-0.2-0.1-0.2-0.6-0.7-0.10.10-0.7-0.3-0.7-0.7000.90.20-0.2-0.70.10.1-0.50LeadLead

    1289.85.73.33.255.14.51.64.210.40.30.70.200.10.80-0.10.1-0.200.2-0.100.31.1-0.10.50.10.3-0.3-0.2-0.80.1-0.40.10.2-0.3-0.5-0.50.2-0.4-0.4-0.3-0.6-1-0.2-0.3-0.4-0.9-0.4-0.3-0.2-0.6-0.5-1-0.5-2.3-1.9-0.5-1.6-2-2.1-2.4-2.4OptimizedOptimized

    149.66.554.83.33.12.42110.90.80.40.40.30.20.20.20.10.10.10.10.10.10000000-0.1-0.1-0.1-0.1-0.2-0.2-0.2-0.2-0.3-0.3-0.3-0.4-0.4-0.5-0.5-0.5-0.6-0.6-0.6-0.7-0.7-0.7-0.7-0.8-1-1.2-1.2-1.3-1.3-1.4-1.6-1.8-2.1-2.2-2.2-2.4ToxinToxin

    153.30.90.81.60.70.30.90.50.10.1-0.1-0.10.2-0.20.10.80.2-0.20.1-1.2-0.31.4-0.2-0.1-0.41.40.3-0.90.1-0.1-0.61.40.40.40.70.20.50.1-0.4-0.70.40.50.5-0.1-0.3-0.7-1.10.60.3-1-1.1-1.1-0.31.6-0.3-0.2-1.1-1.8-0.4-1.1-1.9-1.10.10-0.4-1.8-1.7Best DrugBest Drug

    Gene Index

    Differential Expression

    Chart2

    1010-0.60.10-0.4100.20.100.10-0.3-0.2-0.10.1-0.31.10.80-0.10.6000.90-0.4-0.31.20.700.9-0.1-0.40.7-0.7-0.21.2-0.2-0.1-0.1-0.6-0.2-0.3-0.1-0.10.20.1-0.6-0.10.10.2-0.1-0.1-0.7-0.100.20.11.10.300-0.30.5-0.1-0.30.1

    440.2-0.100.10.3-0.210.40.20.10-0.9-0.7-0.10.1-0.71.11.5-0.70.10.8-0.50.20.8-0.1-0.5-0.71.50.9-0.30.9-0.301-0.3-0.720.7-1.1-0.7-0.5-0.9-0.9-0.3-0.2-0.1-0.2-0.6-0.7-0.10.10-0.7-0.3-0.7-0.7000.90.20-0.2-0.70.10.1-0.50

    121289.85.73.33.255.14.51.64.210.40.30.70.200.10.80-0.10.1-0.200.2-0.100.31.1-0.10.50.10.3-0.3-0.2-0.80.1-0.40.10.2-0.3-0.5-0.50.2-0.4-0.4-0.3-0.6-1-0.2-0.3-0.4-0.9-0.4-0.3-0.2-0.6-0.5-1-0.5-2.3-1.9-0.5-1.6-2-2.1-2.4-2.4

    14149.66.554.83.33.12.42110.90.80.40.40.30.20.20.20.10.10.10.10.10.10000000-0.1-0.1-0.1-0.1-0.2-0.2-0.2-0.2-0.3-0.3-0.3-0.4-0.4-0.5-0.5-0.5-0.6-0.6-0.6-0.7-0.7-0.7-0.7-0.8-1-1.2-1.2-1.3-1.3-1.4-1.6-1.8-2.1-2.2-2.2-2.4

    15153.30.90.81.60.70.30.90.50.10.1-0.1-0.10.2-0.20.10.80.2-0.20.1-1.2-0.31.4-0.2-0.1-0.41.40.3-0.90.1-0.1-0.61.40.40.40.70.20.50.1-0.4-0.70.40.50.5-0.1-0.3-0.7-1.10.60.3-1-1.1-1.1-0.31.6-0.3-0.2-1.1-1.8-0.4-1.1-1.9-1.10.10-0.4-1.8-1.7

    Gene Index

    Differential Expression

    Chart3

    1010-0.60.10-0.4100.20.100.10-0.3-0.2-0.10.1-0.31.10.80-0.10.6000.90-0.4-0.31.20.700.9-0.1-0.40.7-0.7-0.21.2-0.2-0.1-0.1-0.6-0.2-0.3-0.1-0.10.20.1-0.6-0.10.10.2-0.1-0.1-0.7-0.100.20.11.10.300-0.30.5-0.1-0.30.1

    440.2-0.100.10.3-0.210.40.20.10-0.9-0.7-0.10.1-0.71.11.5-0.70.10.8-0.50.20.8-0.1-0.5-0.71.50.9-0.30.9-0.301-0.3-0.720.7-1.1-0.7-0.5-0.9-0.9-0.3-0.2-0.1-0.2-0.6-0.7-0.10.10-0.7-0.3-0.7-0.7000.90.20-0.2-0.70.10.1-0.50

    121289.85.73.33.255.14.51.64.210.40.30.70.200.10.80-0.10.1-0.200.2-0.100.31.1-0.10.50.10.3-0.3-0.2-0.80.1-0.40.10.2-0.3-0.5-0.50.2-0.4-0.4-0.3-0.6-1-0.2-0.3-0.4-0.9-0.4-0.3-0.2-0.6-0.5-1-0.5-2.3-1.9-0.5-1.6-2-2.1-2.4-2.4

    14149.66.554.83.33.12.42110.90.80.40.40.30.20.20.20.10.10.10.10.10.10000000-0.1-0.1-0.1-0.1-0.2-0.2-0.2-0.2-0.3-0.3-0.3-0.4-0.4-0.5-0.5-0.5-0.6-0.6-0.6-0.7-0.7-0.7-0.7-0.8-1-1.2-1.2-1.3-1.3-1.4-1.6-1.8-2.1-2.2-2.2-2.4

    16163.30.90.81.60.70.30.90.50.10.1-0.1-0.10.2-0.20.10.80.2-0.20.1-1.2-0.31.4-0.2-0.1-0.41.40.3-0.90.1-0.1-0.61.40.40.40.70.20.50.1-0.4-0.70.40.50.5-0.1-0.3-0.7-1.10.60.3-1-1.1-1.1-0.31.6-0.3-0.2-1.1-1.8-0.4-1.1-1.9-1.10.10-0.4-1.8-1.7

    550.2-0.53.72.44.93.8008.2-0.36.4-0.8-7.37.54.3-21.80.40.90.20.40.4-0.44.2-0.3-4.3-2.10.41.50.2-4.11.8-0.1-4.20-4.34.2-0.60.93.1-2.3-7.8-0.70.1-4.1-7.45.5-0.1-6.20.7-4.2-0.20.5-0.6-0.7-0.7-0.6-0.2-0.80.1-1.1-2.2-0.7-2.8-6.1-5.1-1-3.1

    Gene Index

    Differential Expression (fold change)

    Sheet2

    ABCDEF

    1041214165

    1041214165

    -0.60.289.63.30.2

    0.1-0.19.86.50.9-0.5

    005.750.83.7

    -0.40.13.34.81.62.4

    10.33.23.30.74.9

    0-0.253.10.33.8

    0.215.12.40.90

    0.10.44.520.50

    00.21.610.18.2

    0.10.14.210.1-0.3

    0010.9-0.16.4

    -0.3-0.90.40.8-0.1-0.8

    -0.2-0.70.30.40.2-7.3

    -0.1-0.10.70.4-0.27.5

    0.10.10.20.30.14.3

    -0.3-0.700.20.8-21.8

    1.11.10.10.20.20.4

    0.81.50.80.2-0.20.9

    0-0.700.10.10.2

    -0.10.1-0.10.1-1.20.4

    0.60.80.10.1-0.30.4

    0-0.5-0.20.11.4-0.4

    00.200.1-0.24.2

    0.90.80.20.1-0.1-0.3

    0-0.1-0.10-0.4-4.3

    -0.4-0.5001.4-2.1

    -0.3-0.70.300.30.4

    1.21.51.10-0.91.5

    0.70.9-0.100.10.2

    0-0.30.50-0.1-4.1

    0.90.90.10-0.61.8

    -0.1-0.30.3-0.11.4-0.1

    -0.40-0.3-0.10.4-4.2

    0.71-0.2-0.10.40

    -0.7-0.3-0.8-0.10.7-4.3

    -0.2-0.70.1-0.20.24.2

    1.22-0.4-0.20.5-0.6

    -0.20.70.1-0.20.10.9

    -0.1-1.10.2-0.2-0.43.1

    -0.1-0.7-0.3-0.3-0.7-2.3

    -0.6-0.5-0.5-0.30.4-7.8

    -0.2-0.9-0.5-0.30.5-0.7

    -0.3-0.90.2-0.40.50.1

    -0.1-0.3-0.4-0.4-0.1-4.1

    -0.1-0.2-0.4-0.5-0.3-7.4

    0.2-0.1-0.3-0.5-0.75.5

    0.1-0.2-0.6-0.5-1.1-0.1

    -0.6-0.6-1-0.60.6-6.2

    -0.1-0.7-0.2-0.60.30.7

    0.1-0.1-0.3-0.6-1-4.2

    0.20.1-0.4-0.7-1.1-0.2

    -0.10-0.9-0.7-1.10.5

    -0.1-0.7-0.4-0.7-0.3-0.6

    -0.7-0.3-0.3-0.71.6-0.7

    -0.1-0.7-0.2-0.8-0.3-0.7

    0-0.7-0.6-1-0.2-0.6

    0.20-0.5-1.2-1.1-0.2

    0.10-1-1.2-1.8-0.8

    1.10.9-0.5-1.3-0.40.1

    0.30.2-2.3-1.3-1.1-1.1

    00-1.9-1.4-1.9-2.2

    0-0.2-0.5-1.6-1.1-0.7

    -0.3-0.7-1.6-1.80.1-2.8

    0.50.1-2-2.10-6.1

    -0.10.1-2.1-2.2-0.4-5.1

    -0.3-0.5-2.4-2.2-1.8-1

    0.10-2.4-2.4-1.7-3.1

    Sheet1

    Genes022Q3614022X3615022I36182243616022B3617022O4498TSACompetitionLeadOptimizedToxinBest DrugToxin

    TARGET510412141514

    TARGET510412141514

    Human mRNA for gravin; complete cds. {IM343061}-1.21.6-1.2-6-10.6-4.30.2-0.60.289.63.39.6

    Human prolactin receptor-associated prot {IM486070}1.5-1.11.1-10.8-7.5-1.9-0.50.1-0.19.86.50.96.5

    Human insulin-like growth factor binding {IM158337}-4.7-11-6.7-6-1.83.7005.750.85

    ESTs {IM510482}-3.41.4-1.1-4.3-5.8-2.62.4-0.40.13.34.81.64.8

    METALLOTHIONEIN-IF {IM245990}-5.9-2-1.3-2.2-4.3-1.74.910.33.23.30.73.3

    Human 14 kd lectin mRNA; complete cds. {IM301144}-4.8-11.2-6-4.1-1.33.80-0.253.10.33.1

    G0/G1 SWITCH REGULATORY PROTEIN 8 {IM512498}1-1.2-2-6.1-3.4-1.900.215.12.40.92.4

    Human cellular retinol-binding protein m {IM322797}-1-1.1-1.4-5.5-3-1.500.10.44.520.52

    ESTs {IM416831}-9.2-1-1.2-2.6-2-1.18.200.21.610.11

    Human mRNA for SM22 alpha; complete cds. {IM359457}1.3-1.1-1.1-5.2-2-1.1-0.30.10.14.210.11

    Human heterogenous nuclear RNA W16W. {IM486758}-7.4-11-2-1.91.16.40010.9-0.10.9

    Human metalloprotease/disintegrin/cystei {IM324266}1.81.31.9-1.4-1.81.1-0.8-0.3-0.90.40.8-0.10.8

    EUKARYOTIC INITIATION FACTOR 4 GAMMA {IM487212}8.31.21.7-1.3-1.4-1.2-7.3-0.2-0.70.30.40.20.4

    Human clone 137308 mRNA {IM252491}-8.51.11.1-1.7-1.41.27.5-0.1-0.10.70.4-0.20.4

    Human G9 gene encoding sialidase. {IM487925}-5.3-1.1-1.1-1.2-1.3-1.14.30.10.10.20.30.10.3

    STROMELYSIN-3 PRECURSOR {IM471174}22.81.31.71-1.2-1.8-21.8-0.3-0.700.20.80.2

    ESTs {IM417125}-1.4-2.1-2.1-1.1-1.2-1.20.41.11.10.10.20.20.2

    Human homolog of Yeast IPP isomerase. {IM487909}-1.9-1.8-2.5-1.8-1.21.20.90.81.50.80.2-0.20.2

    ESTs {IM136101}-1.211.71-1.1-1.10.20-0.700.10.10.1

    ESTs {IM258761}-1.41.1-1.11.1-1.12.20.4-0.10.1-0.10.1-1.20.1

    ESTs {IM376386}-1.4-1.6-1.8-1.1-1.11.30.40.60.80.10.1-0.30.1

    ESTs {IM486601}1.411.51.2-1.1-2.4-0.40-0.5-0.20.11.40.1

    Human betaine:homocysteine methyltransfe {IM294688}-5.2-1-1.21-1.11.24.200.200.1-0.20.1

    Human hepatic squalene synthetase mRNA; {IM510298}1.3-1.9-1.8-1.2-1.11.1-0.30.90.80.20.1-0.10.1

    Human alpha-1 acid glycoprotein mRNA; co {IM429925}5.311.11.1-11.4-4.30-0.1-0.10-0.40

    Human alpha-1-antichymotrypsin mRNA; 3' {IM488360}3.11.41.5-11-2.4-2.1-0.4-0.5001.40

    Human CDw40 mRNA for nerve growth factor {IM261517}-1.41.31.7-1.31-1.30.4-0.3-0.70.300.30

    Human mRNA for CAB1; complete cds. {IM487763}-2.5-2.2-2.5-2.1-11.91.51.21.51.10-0.90

    Human mRNA for fungal sterol-C5-desatura {IM305890}-1.2-1.7-1.91.1-1-1.10.20.70.9-0.100.10

    Human mRNA for RTP; complete cds. {IM486202}5.1-11.3-1.5-11.1-4.10-0.30.50-0.10

    Human ribosomal protein L39 mRNA; comple {IM487908}-2.8-1.9-1.9-1.1-11.61.80.90.90.10-0.60

    ESTs {IM198384}1.11.11.3-1.31.1-2.4-0.1-0.1-0.30.3-0.11.4-0.1

    ESTs {IM510536}5.21.411.31.1-1.4-4.2-0.40-0.3-0.10.4-0.1

    Human 3-hydroxy-3-methylglutaryl CoA red {IM510196}-1-1.7-21.21.1-1.400.71-0.2-0.10.4-0.1

    Human mRNA for ATP synthase subunit c en {IM487373}5.31.71.31.81.1-1.7-4.3-0.7-0.3-0.8-0.10.7-0.1

    brain-expressed HHCPA78 homolog [Human; {IM488488}-5.21.21.7-1.11.2-1.24.2-0.2-0.70.1-0.20.2-0.2

    ESTs {IM71001}1.6-2.2-31.41.2-1.5-0.61.22-0.4-0.20.5-0.2

    Human mRNA for placental leucine aminope {IM115166}-1.91.2-1.7-1.11.2-1.10.9-0.20.70.1-0.20.1-0.2

    mss4=Zn2+ binding protein/guanine nucleo {IM359769}-4.11.12.1-1.21.21.43.1-0.1-1.10.2-0.2-0.4-0.2

    ESTs {IM114101}3.31.11.71.31.31.7-2.3-0.1-0.7-0.3-0.3-0.7-0.3

    Human beta-migrating plasminogen activat {IM487394}8.81.61.51.51.3-1.4-7.8-0.6-0.5-0.5-0.30.4-0.3

    LYSOZYME C PRECURSOR {IM293925}1.71.21.91.51.3-1.5-0.7-0.2-0.9-0.5-0.30.5-0.3

    ESTs {IM357179}-1.11.31.9-1.21.4-1.50.1-0.3-0.90.2-0.40.5-0.4

    Human transformation-related protein mRNA {IM509889}5.11.11.31.41.41.1-4.1-0.1-0.3-0.4-0.4-0.1-0.4

    Human ceruloplasmin mRNA. {IM223350}8.41.11.21.41.51.3-7.4-0.1-0.2-0.4-0.5-0.3-0.5

    Human chromosome 11 cosmid A9 including {IM187563}-6.5-1.21.11.31.51.75.50.2-0.1-0.3-0.5-0.7-0.5

    Human mRNA for plasma gelsolin. {IM359675}1.1-1.11.21.61.52.1-0.10.1-0.2-0.6-0.5-1.1-0.5

    ENDOTHELIAL ACTIN-BINDING PROTEIN {IM487418}7.21.61.621.6-1.6-6.2-0.6-0.6-1-0.60.6-0.6

    Human aldolase A mRNA; complete cds. {IM470436}-1.71.11.71.21.6-1.30.7-0.1-0.7-0.2-0.60.3-0.6

    Human mRNA for annexin IV (carbohydrate- {IM485221}5.2-1.11.11.31.62-4.20.1-0.1-0.3-0.6-1-0.6

    ESTs {IM416762}1.2-1.2-1.11.41.72.1-0.20.20.1-0.4-0.7-1.1-0.7

    Human mRNA for heparan sulfate proteagly {IM346135}-1.51.111.91.72.10.5-0.10-0.9-0.7-1.1-0.7

    Human nucleotide-binding protein mRNA; c {IM376052}1.61.11.71.41.71.3-0.6-0.1-0.7-0.4-0.7-0.3-0.7

    IEX-1=radiation-inducible immediate-earl {IM471556}1.71.71.31.31.7-2.6-0.7-0.7-0.3-0.3-0.71.6-0.7

    ESTs {IM357967}1.71.11.71.21.81.3-0.7-0.1-0.7-0.2-0.8-0.3-0.8

    Human alpha-2-macroglobulin mRNA; 3' end {IM488103}1.611.71.621.2-0.60-0.7-0.6-1-0.2-1

    citrate synthase precursor (EC 4.1.3.7) {IM347719}1.2-1.211.52.22.1-0.20.20-0.5-1.2-1.1-1.2

    Human apolipoprotein C-III (apoC-III) mR {IM364983}1.8-1.1122.22.8-0.80.10-1-1.2-1.8-1.2

    ESTs {IM415326}-1.1-2.1-1.91.52.31.40.11.10.9-0.5-1.3-0.4-1.3

    Human aldehyde dehydrogenase I (ALDH-1) {IM429771}2.1-1.3-1.23.32.32.1-1.10.30.2-2.3-1.3-1.1-1.3

    EST {IM71410}3.2-112.92.42.9-2.200-1.9-1.4-1.9-1.4

    Human tryptophan oxygenase (TDO) mRNA; c {IM327488}1.711.21.52.62.1-0.70-0.2-0.5-1.6-1.1-1.6

    ESTs {IM269320}3.81.31.72.62.8-1.1-2.8-0.3-0.7-1.6-1.80.1-1.8

    Human ApoH mRNA for apolipoprotein H (be {IM234212}7.1-1.5-1.133.11-6.10.50.1-2-2.10-2.1

    beta 2-glycoprotein I [Human; HepG2 hepa {IM358822}6.11.1-1.13.13.21.4-5.1-0.10.1-2.1-2.2-0.4-2.2

    Human glucose-6-phosphatase mRNA; comple {IM124592}21.31.51.43.22.8-1-0.3-0.5-2.4-2.2-1.8-2.2

    Human phenylalanine hydroxylase (PAH) mu {IM243196}4.1-1.113.43.42.7-3.10.10-2.4-2.4-1.7-2.4

    Sheet1

    50.2-0.53.72.44.93.8008.2-0.36.4-0.8-7.37.54.3-21.80.40.90.20.40.4-0.44.2-0.3-4.3-2.10.41.50.2-4.11.8-0.1-4.20-4.34.2-0.60.93.1-2.3-7.8-0.70.1-4.1-7.45.5-0.1-6.20.7-4.2-0.20.5-0.6-0.7-0.7-0.6-0.2-0.80.1-1.1-2.2-0.7-2.8-6.1-5.1-1-3.1TSATSA

    10-0.60.10-0.4100.20.100.10-0.3-0.2-0.10.1-0.31.10.80-0.10.6000.90-0.4-0.31.20.700.9-0.1-0.40.7-0.7-0.21.2-0.2-0.1-0.1-0.6-0.2-0.3-0.1-0.10.20.1-0.6-0.10.10.2-0.1-0.1-0.7-0.100.20.11.10.300-0.30.5-0.1-0.30.1CompetitionCompetition

    40.2-0.100.10.3-0.210.40.20.10-0.9-0.7-0.10.1-0.71.11.5-0.70.10.8-0.50.20.8-0.1-0.5-0.71.50.9-0.30.9-0.301-0.3-0.720.7-1.1-0.7-0.5-0.9-0.9-0.3-0.2-0.1-0.2-0.6-0.7-0.10.10-0.7-0.3-0.7-0.7000.90.20-0.2-0.70.10.1-0.50LeadLead

    1289.85.73.33.255.14.51.64.210.40.30.70.200.10.80-0.10.1-0.200.2-0.100.31.1-0.10.50.10.3-0.3-0.2-0.80.1-0.40.10.2-0.3-0.5-0.50.2-0.4-0.4-0.3-0.6-1-0.2-0.3-0.4-0.9-0.4-0.3-0.2-0.6-0.5-1-0.5-2.3-1.9-0.5-1.6-2-2.1-2.4-2.4OptimizedOptimized

    149.66.554.83.33.12.42110.90.80.40.40.30.20.20.20.10.10.10.10.10.10000000-0.1-0.1-0.1-0.1-0.2-0.2-0.2-0.2-0.3-0.3-0.3-0.4-0.4-0.5-0.5-0.5-0.6-0.6-0.6-0.7-0.7-0.7-0.7-0.8-1-1.2-1.2-1.3-1.3-1.4-1.6-1.8-2.1-2.2-2.2-2.4ToxinToxin

    153.30.90.81.60.70.30.90.50.10.1-0.1-0.10.2-0.20.10.80.2-0.20.1-1.2-0.31.4-0.2-0.1-0.41.40.3-0.90.1-0.1-0.61.40.40.40.70.20.50.1-0.4-0.70.40.50.5-0.1-0.3-0.7-1.10.60.3-1-1.1-1.1-0.31.6-0.3-0.2-1.1-1.8-0.4-1.1-1.9-1.10.10-0.4-1.8-1.7Best DrugBest Drug

    Gene Index

    Differential Expression

    6 drug 2x up

    GEMIDLocationDiffExprBalancedDiffExprP1SignalP1S/BP1Area%P2BalancedSignalP2SignalP2S/BP2Area%Probe1P1DescriptionProbe2P2DescriptionElementFilePathGeneIDPlateRowPlateColPlateIDGEMControlElementGeneName

    22436169536-1.51174814.39816852633998293Y0055Control 1(LF/C)293Q0059T138067''-8239H42160271STROMELYSIN-3 PRECURSOR {IM471174}

    22436164035-1.9-1.2249514.189295646198.589293Y0055Control 1(LF/C)293Q0059T138067''-6217G10021N0250mss4=Zn2+ binding protein/guanine nucleo {IM359769}

    22436168335-3.5-2.23013.17867410533.978293Y0055Control 1(LF/C)293Q0059T138067''-3340H2021D0212METALLOTHIONEIN-IF {IM245990}

    22436168632-11.5166813.586109317085.886293Y0055Control 1(LF/C)293Q0059T138067''-4618B8021P0232LYSOZYME C PRECURSOR {IM293925}

    22436162063-1.21.3789043.61005913923921100293Y0055Control 1(LF/C)293Q0059T138067''-8328G9021D0272IEX-1=radiation-inducible immediate-earl {IM471556}

    22436168855-1.11.5137710.98294714794.982293Y0055Control 1(LF/C)293Q0059T138067''-5508D10021O0241Human tryptophan oxygenase (TDO) mRNA; c {IM327488}

    22436169876-1.11.4178412.4100124919516.3100293Y0055Control 1(LF/C)293Q0059T138067''-9591H12021B0290Human transformation-related protein mRNA {IM509889}

    22436167236-1.7-1.15884.57165110173.471293Y0055Control 1(LF/C)293Q0059T138067''-9034B72150280Human ribosomal protein L39 mRNA; comple {IM487908}

    22436167145-16.9-10.83653.41003938615315.9100293Y0055Control 1(LF/C)293Q0059T138067''-8672D52150276Human prolactin receptor-associated prot {IM486070}

    224361633252.23.41247169.11003686575913.1100293Y0055Control 1(LF/C)293Q0059T138067''-3284C6021D0212Human phenylalanine hydroxylase (PAH) mu {IM243196}

    22436164167-1.11.4872153.9846114955323.784293Y0055Control 1(LF/C)293Q0059T138067''-6745C10021T0256Human nucleotide-binding protein mRNA; c {IM376052}

    22436161528-8.2-5.28505.51004436693116.3100293Y0055Control 1(LF/C)293Q0059T138067''-6190E7021N0250Human mRNA for SM22 alpha; complete cds. {IM359457}

    22436167149-2.3-1.510607.789154824196.889293Y0055Control 1(LF/C)293Q0059T138067''-8692F12150276Human mRNA for RTP; complete cds. {IM486202}

    2243616402611.6933855.981572489432481293Y0055Control 1(LF/C)293Q0059T138067''-6187E4021N0250Human mRNA for plasma gelsolin. {IM359675}

    22436165145-1.7-1.1250315.1892679418610.989293Y0055Control 1(LF/C)293Q0059T138067''-586B1021S0184Human mRNA for placental leucine aminope {IM115166}

    224361664281.21.96575873535522.487293Y0055Control 1(LF/C)293Q0059T138067''-5798D11021N0246Human mRNA for heparan sulfate proteagly {IM346135}

    22436166370-9.4-62802.660168826387.260293Y0055Control 1(LF/C)293Q0059T138067''-5574B32190244Human mRNA for gravin; complete cds. {IM343061}

    22436161226-1.51.1201410.2100190329736.5100293Y0055Control 1(LF/C)293Q0059T138067''-4985A3021H0236Human mRNA for fungal sterol-C5-desatura {IM305890}

    22436162236-3.3-2.18616100182828577.3100293Y0055Control 1(LF/C)293Q0059T138067''-9022A72150280Human mRNA for CAB1; complete cds. {IM487763}

    224361622111.11.8577031.51003220503110.5100293Y0055Control 1(LF/C)293Q0059T138067''-8924A5021Q0279Human mRNA for ATP synthase subunit c en {IM487373}

    22436167093-1.21.314538.887115718085.287293Y0055Control 1(LF/C)293Q0059T138067''-8460B9021R0274Human mRNA for annexin IV (carbohydrate- {IM485221}

    22436163828-2.2-1.4723546.598102701604737.498293Y0055Control 1(LF/C)293Q0059T138067''-5394C4021H0240Human metalloprotease/disintegrin/cystei {IM324266}

    2243616444-10.5-6.7183410.493123791934236.693293Y0055Control 1(LF/C)293Q0059T138067''-1758C11021C0196Human insulin-like growth factor binding {IM158337}

    22436167227-2.7-1.87155.288125419605.788293Y0055Control 1(LF/C)293Q0059T138067''-9004H1021Q0279Human homolog of Yeast IPP isomerase. {IM487909}

    22436164690-3.2-28556.687174127207.687293Y0055Control 1(LF/C)293Q0059T138067''-8835A12021J0278Human heterogenous nuclear RNA W16W. {IM486758}

    22436169908-1.9-1.2243217.4872984466213.487293Y0055Control 1(LF/C)293Q0059T138067''-9727D4021P0292Human hepatic squalene synthetase mRNA; {IM510298}

    22436167677-1.11.43723.3722714232.172293Y0055Control 1(LF/C)293Q0059T138067''-711D6021Z0185Human glucose-6-phosphatase mRNA; comple {IM124592}

    22436169736-1.8-1.27727.49489714025.494293Y0055Control 1(LF/C)293Q0059T138067''-9035B82150280Human G9 gene encoding sialidase. {IM487925}

    22436163359-2.6-1.711777.6100196530708100293Y0055Control 1(LF/C)293Q0059T138067''-3424G2021K0213Human clone 137308 mRNA {IM252491}

    2243616630-1.21.3349717.8100261340838.8100293Y0055Control 1(LF/C)293Q0059T138067''-2501A11021L0204Human chromosome 11 cosmid A9 including {IM187563}

    2243616757-1.11.427660120.796195503054751.196293Y0055Control 1(LF/C)293Q0059T138067''-3015E1021K0209Human ceruloplasmin mRNA. {IM223350}

    22436161307-8.6-5.55993.5100330251599.4100293Y0055Control 1(LF/C)293Q0059T138067''-5303C92120239Human cellular retinol-binding protein m {IM322797}

    22436168397-2.1-1.3119610.5100159524927.8100293Y0055Control 1(LF/C)293Q0059T138067''-3584D6021Y0215Human CDw40 mRNA for nerve growth factor {IM261517}

    22436161144-1.514193.2704046312.370293Y0055Control 1(LF/C)293Q0059T138067''-4653E7021P0232Human betaine:homocysteine methyltransfe {IM294688}

    22436167211-1.11.5331617.5100227835607.9100293Y0055Control 1(LF/C)293Q0059T138067''-8936B5021Q0279Human beta-migrating plasminogen activat {IM487394}

    224361665971.32253116.6100126019695.7100293Y0055Control 1(LF/C)293Q0059T138067''-6484F12180253Human apolipoprotein C-III (apoC-III) mR {IM364983}

    224361632861.931437786.11004726738518.4100293Y0055Control 1(LF/C)293Q0059T138067''-3122E12021Z0210Human ApoH mRNA for apolipoprotein H (be {IM234212}

    22436169748-11.6157113.997101215815.997293Y0055Control 1(LF/C)293Q0059T138067''-9083F82150280Human alpha-2-macroglobulin mRNA; 3' end {IM488103}

    22436162275-1.6-1880453.410089681401334100293Y0055Control 1(LF/C)293Q0059T138067''-9184G1021C0281Human alpha-1-antichymotrypsin mRNA; 3' {IM488360}

    22436169438-1.41.1212217.41001873292610.1100293Y0055Control 1(LF/C)293Q0059T138067''-7839F122160267Human alpha-1 acid glycoprotein mRNA; co {IM429925}

    22436169510-1.31.2204714.690171626828.790293Y0055Control 1(LF/C)293Q0059T138067''-8127F12021Z0270Human aldolase A mRNA; complete cds. {IM470436}

    224361619382.13.3523630.3100158624786.7100293Y0055Control 1(LF/C)293Q0059T138067''-7826E112160267Human aldehyde dehydrogenase I (ALDH-1) {IM429771}

    22436169877-1.31.2132710.577112817625.977293Y0055Control 1(LF/C)293Q0059T138067''-9605B2021I0291Human 3-hydroxy-3-methylglutaryl CoA red {IM510196}

    22436161200-9.4-6231513.6100138752168045100293Y0055Control 1(LF/C)293Q0059T138067''-4873G112130234Human 14 kd lectin mRNA; complete cds. {IM301144}

    22436168863-5.4-3.52352.76481412724.564293Y0055Control 1(LF/C)293Q0059T138067''-5548H2021O0241Human 1;2-cyclic-inositol-phosphate phos {IM328683}

    22436164940-9.5-6.12672.954162625407.754293Y0055Control 1(LF/C)293Q0059T138067''-9839E8021W0293G0/G1 SWITCH REGULATORY PROTEIN 8 {IM512498}

    22436164721-2-1.3560437.4847251113292984293Y0055Control 1(LF/C)293Q0059T138067''-8969E2021Q0279EUKARYOTIC INITIATION FACTOR 4 GAMMA {IM487212}

    22436165049-1.11.43913532804371.953293Y0055Control 1(LF/C)293Q0059T138067''-202B12100180ESTs {IM71001}

    22436162431-1.21.320821491154824196.891293Y0055Control 1(LF/C)293Q0059T138067''-9808C1021W0293ESTs {IM510536}

    22436167421-6.7-4.32822.776120118775.376293Y0055Control 1(LF/C)293Q0059T138067''-9776H5021P0292ESTs {IM510482}

    22436164682-1.31.2114187194114714.271293Y0055Control 1(LF/C)293Q0059T138067''-8807G8021C0277ESTs {IM486601}

    22436162958??2672.2382774331.838293Y0055Control 1(LF/C)293Q0059T138067''-1823A4021J0197ESTs {IM43958}

    22436161833-1.7-1.1418223.61004662728516.6100293Y0055Control 1(LF/C)293Q0059T138067''-7412C52.10E+264ESTs {IM417125}

    22436164314-4-2.633837586813574.175293Y0055Control 1(LF/C)293Q0059T138067''-7339E42170262ESTs {IM416831}

    22436166814-1.11.414559.2100101815914.6100293Y0055Control 1(LF/C)293Q0059T138067''-7350F32170262ESTs {IM416762}

    22436164272-11.5242015.681161825287.181293Y0055Control 1(LF/C)293Q0059T138067''-7171G4021T0260ESTs {IM415326}

    22436161688-1.7-1.1247614.51002664416210.4100293Y0055Control 1(LF/C)293Q0059T138067''-6834C32100257ESTs {IM376386}

    22436168997-1.31.2174016.596140621977.796293Y0055Control 1(LF/C)293Q0059T138067''-6081D62180249ESTs {IM357967}

    22436168978-1.9-1.23633.8794316733.279293Y0055Control 1(LF/C)293Q0059T138067''-6007F42110248ESTs {IM357179}

    224361634251.72.624810144.49295381490328.392293Y0055Control 1(LF/C)293Q0059T138067''-3688E22150216ESTs {IM269320}

    2243616889-1.41.117559.4100162625405.6100293Y0055Control 1(LF/C)293Q0059T138067''-3543A1021Y0215ESTs {IM258761}

    22436168158-2-1.33703.1794777452.779293Y0055Control 1(LF/C)293Q0059T138067''-2630D8021S0205ESTs {IM198384}

    22436167840-1.51327024.5733151492415.673293Y0055Control 1(LF/C)293Q0059T138067''-1359B8021K0192ESTs {IM136101}

    22436162640-1.21.3496025.9863924613213.386293Y0055Control 1(LF/C)293Q0059T138067''-553G4021L0183ESTs {IM114101}

    224361625561.92.91616783.5545540865618.654293Y0055Control 1(LF/C)293Q0059T138067''-217C42100180EST {IM71410}

    224361697201.32250518.992127319896.492293Y0055Control 1(LF/C)293Q0059T138067''-8967D12021Q0279ENDOTHELIAL ACTIN-BINDING PROTEIN {IM487418}

    22436161460-11.51306963.510085881341924.1100293Y0055Control 1(LF/C)293Q0059T138067''-5922G3021U0247citrate synthase precursor (EC 4.1.3.7) {IM347719}

    22436167286-1.8-1.17875.99288413824.592293Y0055Control 1(LF/C)293Q0059T138067''-9230B11021J0282brain-expressed HHCPA78 homolog [Human; {IM488488}

    2243616150923.146933229.9100151662369741.6100293Y0055Control 1(LF/C)293Q0059T138067''-6116G52180249beta 2-glycoprotein I [Human; HepG2 hepa {IM358822}

    022B36179536-1.4-1.2878830.7100108761264625.2100293Y0055Control 1(LF/C)293J0058T397620''-8239H42160271STROMELYSIN-3 PRECURSOR {IM471174}

    022B361740351.11.2394917.694317936969.494293Y0055Control 1(LF/C)293J0058T397620''-6217G10021N0250mss4=Zn2+ binding protein/guanine nucleo {IM359769}

    022B36178335-5.1-4.37283.4100316536809100293Y0055Control 1(LF/C)293J0058T397620''-3340H2021D0212METALLOTHIONEIN-IF {IM245990}

    022B361786321.11.3410616.2100319237129.2100293Y0055Control 1(LF/C)293J0058T397620''-4618B8021P0232LYSOZYME C PRECURSOR {IM293925}

    022B361720631.41.7703438.61004226491411.4100293Y0055Control 1(LF/C)293J0058T397620''-8328G9021D0272IEX-1=radiation-inducible immediate-earl {IM471556}

    022B361788552.22.6348514.1100133315504.1100293Y0055Control 1(LF/C)293J0058T397620''-5508D10021O0241Human tryptophan oxygenase (TDO) mRNA; c {IM327488}

    022B361798761.21.45808241004292499112100293Y0055Control 1(LF/C)293J0058T397620''-9591H12021B0290Human transformation-related protein mRNA {IM509889}

    022B36177236-1.2-114967.264150917554.664293Y0055Control 1(LF/C)293J0058T397620''-9034B72150280Human ribosomal protein L39 mRNA; comple {IM487908}

    022B36177145-8.8-7.510135.31007639888219.9100293Y0055Control 1(LF/C)293J0058T397620''-8672D52150276Human prolactin receptor-associated prot {IM486070}

    022B3617332533.41153350.5100336139089.5100293Y0055Control 1(LF/C)293J0058T397620''-3284C6021D0212Human phenylalanine hydroxylase (PAH) mu {IM243196}

    022B361741671.41.71056848.8816284730717.681293Y0055Control 1(LF/C)293J0058T397620''-6745C10021T0256Human nucleotide-binding protein mRNA; c {IM376052}

    022B36171528-2.4-2206511.91004174485311.5100293Y0055Control 1(LF/C)293J0058T397620''-6190E7021N0250Human mRNA for SM22 alpha; complete cds. {IM359457}

    022B36177149-1.2-118878.594196722876.194293Y0055Control 1(LF/C)293J0058T397620''-8692F12150276Human mRNA for RTP; complete cds. {IM486202}

    022B361740261.31.51399460.38793091082424.487293Y0055Control 1(LF/C)293J0058T397620''-6187E4021N0250Human mRNA for plasma gelsolin. {IM359675}

    022B3617514511.2439121.498360741949.898293Y0055Control 1(LF/C)293J0058T397620''-586B1021S0184Human mRNA for placental leucine aminope {IM115166}

    022B361764281.51.713577.694777904394293Y0055Control 1(LF/C)293J0058T397620''-5798D11021N0246Human mRNA for heparan sulfate proteagly {IM346135}

    022B36176370-12.3-10.63612.91003830445411.3100293Y0055Control 1(LF/C)293J0058T397620''-5574B32190244Human mRNA for gravin; complete cds. {IM343061}

    022B36171226-1.2-114286.969143316664.169293Y0055Control 1(LF/C)293J0058T397620''-4985A3021H0236Human mRNA for fungal sterol-C5-desatura {IM305890}

    022B36172236-1.2-114528.580145916974.680293Y0055Control 1(LF/C)293J0058T397620''-9022A72150280Human mRNA for CAB1; complete cds. {IM487763}

    022B36172211-11.15040281004400511612.5100293Y0055Control 1(LF/C)293J0058T397620''-8924A5021Q0279Human mRNA for ATP synthase subunit c en {IM487373}

    022B361770931.31.6340313.7100217125255.9100293Y0055Control 1(LF/C)293J0058T397620''-8460B9021R0274Human mRNA for annexin IV (carbohydrate- {IM485221}

    022B36173828-2.1-1.8625428.796115631344530.896293Y0055Control 1(LF/C)293J0058T397620''-5394C4021H0240Human metalloprotease/disintegrin/cystei {IM324266}

    022B3617444-7-616789.5100101311178025.4100293Y0055Control 1(LF/C)293J0058T397620''-1758C11021C0196Human insulin-like growth factor binding {IM158337}

    022B36177227-1.4-1.219529.9100240828006.8100293Y0055Control 1(LF/C)293J0058T397620''-9004H1021Q0279Human homolog of Yeast IPP isomerase. {IM487909}

    022B36174690-2.2-1.919458.61003726433311.3100293Y0055Control 1(LF/C)293J0058T397620''-8835A12021J0278Human heterogenous nuclear RNA W16W. {IM486758}

    022B36179908-1.3-1.1384918.1964375508712.996293Y0055Control 1(LF/C)293J0058T397620''-9727D4021P0292Human hepatic squalene synthetase mRNA; {IM510298}

    022B361776772.73.223089.4717288472.771293Y0055Control 1(LF/C)293J0058T397620''-711D6021Z0185Human glucose-6-phosphatase mRNA; comple {IM124592}

    022B36179736-1.5-1.3383914.21004887568312100293Y0055Control 1(LF/C)293J0058T397620''-9035B82150280Human G9 gene encoding sialidase. {IM487925}

    022B36173359-1.6-1.416549.485231726946.585293Y0055Control 1(LF/C)293J0058T397620''-3424G2021K0213Human clone 137308 mRNA {IM252491}

    022B36176301.31.5436524.3100296434478.2100293Y0055Control 1(LF/C)293J0058T397620''-2501A11021L0204Human chromosome 11 cosmid A9 including {IM187563}

    022B36177571.31.51449671.710097581134623.5100293Y0055Control 1(LF/C)293J0058T397620''-3015E1021K0209Human ceruloplasmin mRNA. {IM223350}

    022B36171307-3.5-35584.168166519365.268293Y0055Control 1(LF/C)293J0058T397620''-5303C92120239Human cellular retinol-binding protein m {IM322797}

    022B36178397-1.11658024.81006438748618.2100293Y0055Control 1(LF/C)293J0058T397620''-3584D6021Y0215Human CDw40 mRNA for nerve growth factor {IM261517}

    022B36171144-1.2-1.14853.4715176012.471293Y0055Control 1(LF/C)293J0058T397620''-4653E7021P0232Human betaine:homocysteine methyltransfe {IM294688}

    022B361772111.11.3625433.41004863565513.5100293Y0055Control 1(LF/C)293J0058T397620''-8936B5021Q0279Human beta-migrating plasminogen activat {IM487394}

    022B361765971.92.2683925.9100308335858.5100293Y0055Control 1(LF/C)293J0058T397620''-6484F12180253Human apolipoprotein C-III (apoC-III) mR {IM364983}

    022B361732862.73.12118869.81006824793516.9100293Y0055Control 1(LF/C)293J0058T397620''-3122E12021Z0210Human ApoH mRNA for apolipoprotein H (be {IM234212}

    022B361797481.721363248.31006945807617.5100293Y0055Control 1(LF/C)293J0058T397620''-9083F82150280Human alpha-2-macroglobulin mRNA; 3' end {IM488103}

    022B36172275-1.11930353.310090211049025.3100293Y0055Control 1(LF/C)293J0058T397620''-9184G1021C0281Human alpha-1-antichymotrypsin mRNA; 3' {IM488360}

    022B36179438-1.2-11768259.4100183582134745.8100293Y0055Control 1(LF/C)293J0058T397620''-7839F122160267Human alpha-1 acid glycoprotein mRNA; co {IM429925}

    022B361795101.41.6503719.591306835688.291293Y0055Control 1(LF/C)293J0058T397620''-8127F12021Z0270Human aldolase A mRNA; complete cds. {IM470436}

    022B3617193822.3359316.5100156118154.6100293Y0055Control 1(LF/C)293J0058T397620''-7826E112160267Human aldehyde dehydrogenase I (ALDH-1) {IM429771}

    022B36179877-1.11.1349813.9100324337719.6100293Y0055Control 1(LF/C)293J0058T397620''-9605B2021I0291Human 3-hydroxy-3-methylglutaryl CoA red {IM510196}

    022B36171200-4.8-4.1272816.6100112311305929.8100293Y0055Control 1(LF/C)293J0058T397620''-4873G112130234Human 14 kd lectin mRNA; complete cds. {IM301144}

    022B36178863-6.9-5.93462.4100205623915.9100293Y0055Control 1(LF/C)293J0058T397620''-5548H2021O0241Human 1;2-cyclic-inositol-phosphate phos {IM328683}

    022B36174940-4-3.45363.456182621236.256293Y0055Control 1(LF/C)293J0058T397620''-9839E8021W0293G0/G1 SWITCH REGULATORY PROTEIN 8 {IM512498}

    022B36174721-1.7-1.462053010089531041126100293Y0055Control 1(LF/C)293J0058T397620''-8969E2021Q0279EUKARYOTIC INITIATION FACTOR 4 GAMMA {IM487212}

    022B3617504911.26203.6705316172.170293Y0055Control 1(LF/C)293J0058T397620''-202B12100180ESTs {IM71001}

    022B36172431-1.11.1209412.982197422956.982293Y0055Control 1(LF/C)293J0058T397620''-9808C1021W0293ESTs {IM510536}

    022B36177421-6.7-5.84793.589277632287.889293Y0055Control 1(LF/C)293J0058T397620''-9776H5021P0292ESTs {IM510482}

    022B36174682-1.3-1.11777978201823466.478293Y0055Control 1(LF/C)293J0058T397620''-8807G8021C0277ESTs {IM486601}

    022B36172958??1832363003491.736293Y0055Control 1(LF/C)293J0058T397620''-1823A4021J0197ESTs {IM43958}

    022B36171833-1.4-1.2436820.2965139597613.796293Y0055Control 1(LF/C)293J0058T397620''-7412C52.10E+264ESTs {IM417125}

    022B36174314-2.4-21633985330838469.485293Y0055Control 1(LF/C)293J0058T397620''-7339E42170262ESTs {IM416831}

    022B361768141.41.7324317.6100194322595.7100293Y0055Control 1(LF/C)293J0058T397620''-7350F32170262ESTs {IM416762}

    022B3617427222.3370816.882162018844.882293Y0055Control 1(LF/C)293J0058T397620''-7171G4021T0260ESTs {IM415326}

    022B36171688-1.3-1.1251312.482271831607.382293Y0055Control 1(LF/C)293J0058T397620''-6834C32100257ESTs {IM376386}

    022B361789971.61.81289845.91007023816619.6100293Y0055Control 1(LF/C)293J0058T397620''-6081D62180249ESTs {IM357967}

    022B361789781.21.426399.8100187321785.5100293Y0055Control 1(LF/C)293J0058T397620''-6007F42110248ESTs {IM357179}

    022B361734252.42.828359115.8100102751194825100293Y0055Control 1(LF/C)293J0058T397620''-3688E22150216ESTs {IM269320}

    022B3617889-1.3-1.111346.467129215023.967293Y0055Control 1(LF/C)293J0058T397620''-3543A1021Y0215ESTs {IM258761}

    022B36178158-1.11.116726.674158218404.574293Y0055Control 1(LF/C)293J0058T397620''-2630D8021S0205ESTs {IM198384}

    022B36177840-1.3-1.1781630.41008566996122.6100293Y0055Control 1(LF/C)293J0058T397620''-1359B8021K0192ESTs {IM136101}

    022B361726401.11.3798226.9906047703114.990293Y0055Control 1(LF/C)293J0058T397620''-553G4021L0183ESTs {IM114101}

    022B3617255622.426724138.857113241316729.757293Y0055Control 1(LF/C)293J0058T397620''-217C42100180EST {IM71410}

    022B361797201.41.6685026.41004196487911.5100293Y0055Control 1(LF/C)293J0058T397620''-8967D12021Q0279ENDOTHELIAL ACTIN-BINDING PROTEIN {IM487418}

    022B361714601.92.2682240100315436679.7100293Y0055Control 1(LF/C)293J0058T397620''-5922G3021U0247citrate synthase precursor (EC 4.1.3.7) {IM347719}

    022B3617728611.218989.394162518905.194293Y0055Control 1(LF/C)293J0058T397620''-9230B11021J0282brain-expressed HHCPA78 homolog [Human; {IM488488}

    022B361715092.83.230844189.110095071105526.8100293Y0055Control 1(LF/C)293J0058T397620''-6116G52180249beta 2-glycoprotein I [Human; HepG2 hepa {IM358822}

    022I361895361.91.7705233.11004229377611.5100293Y0055Control 1(LF/C)293C0057T006603''-8239H42160271STROMELYSIN-3 PRECURSOR {IM471174}

    022I361840352.32.118239.8798697763.379293Y0055Control 1(LF/C)293C0057T006603''-6217G10021N0250mss4=Zn2+ binding protein/guanine nucleo {IM359769}

    022I36188335-1.1-1.33112.5643923502.164293Y0055Control 1(LF/C)293C0057T006603''-3340H2021D0212METALLOTHIONEIN-IF {IM245990}

    022I361886322.21.9262114.784135512104.984293Y0055Control 1(LF/C)293C0057T006603''-4618B8021P0232LYSOZYME C PRECURSOR {IM293925}

    022I361820631.41.3709032.4765601500112.676293Y0055Control 1(LF/C)293C0057T006603''-8328G9021D0272IEX-1=radiation-inducible immediate-earl {IM471556}

    022I361888551.41.2259413.9100213119036.7100293Y0055Control 1(LF/C)293C0057T006603''-5508D10021O0241Human tryptophan oxygenase (TDO) mRNA; c {IM327488}

    022I361898761.51.3454426.11003442307310.2100293Y0055Control 1(LF/C)293C0057T006603''-9591H12021B0290Human transformation-related protein mRNA {IM509889}

    022I36187236-1.7-1.912457.29724122154797293Y0055Control 1(LF/C)293C0057T006603''-9034B72150280Human ribosomal protein L39 mRNA; comple {IM487908}

    022I361871451.31.18594.8897646822.689293Y0055Control 1(LF/C)293C0057T006603''-8672D52150276Human prolactin receptor-associated prot {IM486070}

    022I361833251.11508326.71004982444813.9100293Y0055Control 1(LF/C)293C0057T006603''-3284C6021D0212Human phenylalanine hydroxylase (PAH) mu {IM243196}

    022I361841671.91.7751739.5884465398713.488293Y0055Control 1(LF/C)293C0057T006603''-6745C10021T0256Human nucleotide-binding protein mRNA; c {IM376052}

    022I36181528-1-1.110445.963117410483.563293Y0055Control 1(LF/C)293C0057T006603''-6190E7021N0250Human mRNA for SM22 alpha; complete cds. {IM359457}

    022I361871491.51.3223012.285165314765.585293Y0055Control 1(LF/C)293C0057T006603''-8692F12150276Human mRNA for RTP; complete cds. {IM486202}

    022I361840261.41.2714440.7915739512416.791293Y0055Control 1(LF/C)293C0057T006603''-6187E4021N0250Human mRNA for plasma gelsolin. {IM359675}

    022I36185145-1.5-1.729268125754955744247107.675293Y0055Control 1(LF/C)293C0057T006603''-586B1021S0184Human mRNA for placental leucine aminope {IM115166}

    022I361864281.21190910.2100183216365.5100293Y0055Control 1(LF/C)293C0057T006603''-5798D11021N0246Human mRNA for heparan sulfate proteagly {IM346135}

    022I36186370-1.1-1.23542.6624233781.962293Y0055Control 1(LF/C)293C0057T006603''-5574B32190244Human mRNA for gravin; complete cds. {IM343061}

    022I36181226-1.7-1.914787.4100273624436.7100293Y0055Control 1(LF/C)293C0057T006603''-4985A3021H0236Human mRNA for fungal sterol-C5-desatura {IM305890}

    022I36182236-2.3-2.511776.8100297926607.6100293Y0055Control 1(LF/C)293C0057T006603''-9022A72150280Human mRNA for CAB1; complete cds. {IM487763}

    022I361822111.51.3676634.21005087454211.2100293Y0055Control 1(LF/C)293C0057T006603''-8924A5021Q0279Human mRNA for ATP synthase subunit c en {IM487373}

    022I361870931.21.1341017.6100323828919.2100293Y0055Control 1(LF/C)293C0057T006603''-8460B9021R0274Human mRNA for annexin IV (carbohydrate- {IM485221}

    022I361838282.11.9297417.6100159214215.5100293Y0055Control 1(LF/C)293C0057T006603''-5394C4021H0240Human metalloprotease/disintegrin/cystei {IM324266}

    022I36184441.21222511.7100214019115.9100293Y0055Control 1(LF/C)293C0057T006603''-1758C11021C0196Human insulin-like growth factor binding {IM158337}

    022I36187227-2.2-2.514717.6100367132788.9100293Y0055Control 1(LF/C)293C0057T006603''-9004H1021Q0279Human homolog of Yeast IPP isomerase. {IM487909}

    022I361846901.116364.1806275602.780293Y0055Control 1(LF/C)293C0057T006603''-8835A12021J0278Human heterogenous nuclear RNA W16W. {IM486758}

    022I36189908-1.6-1.83088191005699508816.1100293Y0055Control 1(LF/C)293C0057T006603''-9727D4021P0292Human hepatic squalene synthetase mRNA; {IM510298}

    022I361876771.61.510606.582729651382293Y0055Control 1(LF/C)293C0057T006603''-711D6021Z0185Human glucose-6-phosphatase mRNA; comple {IM124592}

    022I361897361.1-1.1195410.3100205218326.2100293Y0055Control 1(LF/C)293C0057T006603''-9035B82150280Human G9 gene encoding sialidase. {IM487925}

    022I361833591.31.112977.161115110283.861293Y0055Control 1(LF/C)293C0057T006603''-3424G2021K0213Human clone 137308 mRNA {IM252491}

    022I36186301.21.1322417.4100292526128100293Y0055Control 1(LF/C)293C0057T006603''-2501A11021L0204Human chromosome 11 cosmid A9 including {IM187563}

    022I36187571.41.21966478.4100161761444328.8100293Y0055Control 1(LF/C)293C0057T006603''-3015E1021K0209Human ceruloplasmin mRNA. {IM223350}

    022I36181307-1.3-1.45173.1857326542.485293Y0055Control 1(LF/C)293C0057T006603''-5303C92120239Human cellular retinol-binding protein m {IM322797}

    022I361883971.91.7368219.2100220519697.4100293Y0055Control 1(LF/C)293C0057T006603''-3584D6021Y0215Human CDw40 mRNA for nerve growth factor {IM261517}

    022I36181144-1.1-1.23672.8724514032.272293Y0055Control 1(LF/C)293C0057T006603''-4653E7021P0232Human betaine:homocysteine methyltransfe {IM294688}

    022I361872111.71.5543326.6100361932318.7100293Y0055Control 1(LF/C)293C0057T006603''-8936B5021Q0279Human beta-migrating plasminogen activat {IM487394}

    022I361865971.21497627.21004833431512.8100293Y0055Control 1(LF/C)293C0057T006603''-6484F12180253Human apolipoprotein C-III (apoC-III) mR {IM364983}

    022I36183286-1-1.1782441.8968847789925.596293Y0055Control 1(LF/C)293C0057T006603''-3122E12021Z0210Human ApoH mRNA for apolipoprotein H (be {IM234212}

    022I361897481.91.7576826.21003457308710.6100293Y0055Control 1(LF/C)293C0057T006603''-9083F82150280Human alpha-2-macroglobulin mRNA; 3' end {IM488103}

    022I361822751.71.51384167.91009009804420.6100293Y0055Control 1(LF/C)293C0057T006603''-9184G1021C0281Human alpha-1-antichymotrypsin mRNA; 3' {IM488360}

    022I361894381.31.1671135.81005836521117.7100293Y0055Control 1(LF/C)293C0057T006603''-7839F122160267Human alpha-1 acid glycoprotein mRNA; co {IM429925}

    022I361895101.91.7383219.3100222219846.5100293Y0055Control 1(LF/C)293C0057T006603''-8127F12021Z0270Human aldolase A mRNA; complete cds. {IM470436}

    022I36181938-1-1.2429620.81004958442712.5100293Y0055Control 1(LF/C)293C0057T006603''-7826E112160267Human aldehyde dehydrogenase I (ALDH-1) {IM429771}

    022I36189877-1.8-2206112.41004057362213.2100293Y0055Control 1(LF/C)293C0057T006603''-9605B2021I0291Human 3-hydroxy-3-methylglutaryl CoA red {IM510196}

    022I361812001.41.2250012.687200517905.587293Y0055Control 1(LF/C)293C0057T006603''-4873G112130234Human 14 kd lectin mRNA; complete cds. {IM301144}

    022I36188863??2692.4363232881.836293Y0055Control 1(LF/C)293C0057T006603''-5548H2021O0241Human 1;2-cyclic-inositol-phosphate phos {IM328683}

    022I36184940??2792.4573062731.957293Y0055Control 1(LF/C)293C0057T006603''-9839E8021W0293G0/G1 SWITCH REGULATORY PROTEIN 8 {IM512498}

    022I361847211.91.7664337.91003936351412.3100293Y0055Control 1(LF/C)293C0057T006603''-8969E2021Q0279EUKARYOTIC INITIATION FACTOR 4 GAMMA {IM487212}

    022I36185049-2.7-318788.4885701509012.788293Y0055Control 1(LF/C)293C0057T006603''-202B12100180ESTs {IM71001}

    022I361824311.11207211.781206618456.281293Y0055Control 1(LF/C)293C0057T006603''-9808C1021W0293ESTs {IM510536}

    022I361874211-1.15373.8855735122.485293Y0055Control 1(LF/C)293C0057T006603''-9776H5021P0292ESTs {IM510482}

    022I361846821.71.59275.7736095442.673293Y0055Control 1(LF/C)293C0057T006603''-8807G8021C0277ESTs {IM486601}

    022I36182958-2.7-3728440.248216331931562.148293Y0055Control 1(LF/C)293C0057T006603''-1823A4021J0197ESTs {IM43958}

    022I36181833-1.9-2.1484324.69610175908525.196293Y0055Control 1(LF/C)293C0057T006603''-7412C52.10E+264ESTs {IM417125}

    022I36184314-1-1.26844.479795710379293Y0055Control 1(LF/C)293C0057T006603''-7339E42170262ESTs {IM416831}

    022I36186814-1-1.1305915.2100343530678.2100293Y0055Control 1(LF/C)293C0057T006603''-7350F32170262ESTs {IM416762}

    022I36184272-1.7-1.9192111.2773587320310.477293Y0055Control 1(LF/C)293C0057T006603''-7171G4021T0260ESTs {IM415326}

    022I36181688-1.6-1.8187510.6100335929999100293Y0055Control 1(LF/C)293C0057T006603''-6834C32100257ESTs {IM376386}

    022I361889971.91.7754038.71004432395714.1100293Y0055Control 1(LF/C)293C0057T006603''-6081D62180249ESTs {IM357967}

    022I361889782.11.913438.1897246463.189293Y0055Control 1(LF/C)293C0057T006603''-6007F42110248ESTs {IM357179}

    022I361834251.91.71628384.91009728868628.8100293Y0055Control 1(LF/C)293C0057T006603''-3688E22150216ESTs {IM269320}

    022I3618889-1-1.111066.593125311193.793293Y0055Control 1(LF/C)293C0057T006603''-3543A1021Y0215ESTs {IM258761}

    022I361881581.41.35333.4834193742.183293Y0055Control 1(LF/C)293C0057T006603''-2630D8021S0205ESTs {IM198384}

    022I361878401.91.739482183239021347.883293Y0055Control 1(LF/C)293C0057T006603''-1359B8021K0192ESTs {IM136101}

    022I361826401.91.7319316.684188716855.784293Y0055Control 1(LF/C)293C0057T006603''-553G4021L0183ESTs {IM114101}

    022I361825561.1119159103.555190341699549.355293Y0055Control 1(LF/C)293C0057T006603''-217C42100180EST {IM71410}

    022I361897201.71.6451825.2100291226008.5100293Y0055Control 1(LF/C)293C0057T006603''-8967D12021Q0279ENDOTHELIAL ACTIN-BINDING PROTEIN {IM487418}

    022I361814601.111025552.810010165907623100293Y0055Control 1(LF/C)293C0057T006603''-5922G3021U0247citrate synthase precursor (EC 4.1.3.7) {IM347719}

    022I361872861.91.7223111.9100133611934.4100293Y0055Control 1(LF/C)293C0057T006603''-9230B11021J0282brain-expressed HHCPA78 homolog [Human; {IM488488}

    022I361815091-1.137020165.5100403313601078.8100293Y0055Control 1(LF/C)293C0057T006603''-6116G52180249beta 2-glycoprotein I [Human; HepG2 hepa {IM358822}

    022O449895361.1-1.81576084.810028693139295510029340065LF/C293B0066T177552''-8239H42160271STROMELYSIN-3 PRECURSOR {IM471174}

    022O449840352.81.4341920.3100248812085.610029340065LF/C293B0066T177552''-6217G10021N0250mss4=Zn2+ binding protein/guanine nucleo {IM359769}

    022O449883351.2-1.73522.6625932882.16229340065LF/C293B0066T177552''-3340H2021D0212METALLOTHIONEIN-IF {IM245990}

    022O449886321.3-1.5493325.51007634370613.710029340065LF/C293B0066T177552''-4618B8021P0232LYSOZYME C PRECURSOR {IM293925}

    022O44982063-1.3-2.6760944.510019796961035.310029340065LF/C293B0066T177552''-8328G9021D0272IEX-1=radiation-inducible immediate-earl {IM471556}

    022O449888554.42.1725835.9100338816457.110029340065LF/C293B0066T177552''-5508D10021O0241Human tryptophan oxygenase (TDO) mRNA; c {IM327488}

    022O449898762.31.1852351.71007566367315.310029340065LF/C293B0066T177552''-9591H12021B0290Human transformation-related protein mRNA {IM509889}

    022O449872363.21.6178310.49211435553.19229340065LF/C293B0066T177552''-9034B72150280Human ribosomal protein L39 mRNA; comple {IM487908}

    022O449871451.1-1.917599.7100329816016.810029340065LF/C293B0066T177552''-8672D52150276Human prolactin receptor-associated prot {IM486070}

    022O449833255.52.7996962.5100370317988.310029340065LF/C293B0066T177552''-3284C6021D0212Human phenylalanine hydroxylase (PAH) mu {IM243196}

    022O449841672.71.323012116.110017518850431.210029340065LF/C293B0066T177552''-6745C10021T0256Human nucleotide-binding protein mRNA; c {IM376052}

    022O449815281.9-1.116079.88617618554.18629340065LF/C293B0066T177552''-6190E7021N0250Human mRNA for SM22 alpha; complete cds. {IM359457}

    022O449871492.31.1706141.8726388310114.17229340065LF/C293B0066T177552''-8692F12150276Human mRNA for RTP; complete cds. {IM486202}

    022O449840264.22.11525584.81007395359014.510029340065LF/C293B0066T177552''-6187E4021N0250Human mRNA for plasma gelsolin. {IM359675}

    022O449851451.8-1.1407720.5100458122248.410029340065LF/C293B0066T177552''-586B1021S0184Human mRNA for placental leucine aminope {IM115166}

    022O449864284.32.1317915.910015307433.610029340065LF/C293B0066T177552''-5798D11021N0246Human mRNA for heparan sulfate proteagly {IM346135}

    022O44986370-2.1-4.34723.17720539974.37729340065LF/C293B0066T177552''-5574B32190244Human mRNA for gravin; complete cds. {IM343061}

    022O449812261.9-1.1151997716107823.97729340065LF/C293B0066T177552''-4985A3021H0236Human mRNA for fungal sterol-C5-desatura {IM305890}

    022O449822363.91.9259212.19813536573.19829340065LF/C293B0066T177552''-9022A72150280Human mRNA for CAB1; complete cds. {IM487763}

    022O449822111.2-1.7460126.31007980387414.610029340065LF/C293B0066T177552''-8924A5021Q0279Human mRNA for ATP synthase subunit c en {IM487373}

    022O449870934.12474925100238111565.310029340065LF/C293B0066T177552''-8460B9021R0274Human mRNA for annexin IV (carbohydrate- {IM485221}

    022O449838282.21.16584371006035293011.710029340065LF/C293B0066T177552''-5394C4021H0240Human metalloprotease/disintegrin/cystei {IM324266}

    022O44984441.2-1.8304517.8915411262710.79129340065LF/C293B0066T177552''-1758C11021C0196Human insulin-like growth factor binding {IM158337}

    022O449872272.51.2220812.410017888684.410029340065LF/C293B0066T177552''-9004H1021Q0279Human homolog of Yeast IPP isomerase. {IM487909}

    022O449846902.41.1433523.3100379018407.910029340065LF/C293B0066T177552''-8835A12021J0278Human heterogenous nuclear RNA W16W. {IM486758}

    022O449899082.21.1705942.81006701325314.110029340065LF/C293B0066T177552''-9727D4021P0292Human hepatic squalene synthetase mRNA; {IM510298}

    022O449876775.92.8319413.99711225452.89729340065LF/C293B0066T177552''-711D6021Z0185Human glucose-6-phosphatase mRNA; comple {IM124592}

    022O449897361.9-1.1249612.1100264912865.610029340065LF/C293B0066T177552''-9035B82150280Human G9 gene encoding sialidase. {IM487925}

    022O449833592.41.2412124.2100348516927.810029340065LF/C293B0066T177552''-3424G2021K0213Human clone 137308 mRNA {IM252491}

    022O44986303.51.7375223.777218310605.27729340065LF/C293B0066T177552''-2501A11021L0204Human chromosome 11 cosmid A9 including {IM187563}

    022O44987572.61.317413103.48913853672528.68929340065LF/C293B0066T177552''-3015E1021K0209Human ceruloplasmin mRNA. {IM223350}

    022O449813071.4-1.57755.59011535603.29029340065LF/C293B0066T177552''-5303C92120239Human cellular retinol-binding protein m {IM322797}

    022O449883971.6-1.3390823.2975069246110.69729340065LF/C293B0066T177552''-3584D6021Y0215Human CDw40 mRNA for nerve growth factor {IM261517}

    022O449811442.51.27525796092962.27929340065LF/C293B0066T177552''-4653E7021P0232Human betaine:homocysteine methyltransfe {IM294688}

    022O449872111.4-1.4697835.410010048487820.110029340065LF/C293B0066T177552''-8936B5021Q0279Human beta-migrating plasminogen activat {IM487394}

    022O449865975.82.815136791005411262710.910029340065LF/C293B0066T177552''-6484F12180253Human apolipoprotein C-III (apoC-III) mR {IM364983}

    022O449832862.1158068330.910055922271479910029340065LF/C293B0066T177552''-3122E12021Z0210Human ApoH mRNA for apolipoprotein H (be {IM234212}

    022O449897482.41.2130458110011119539824.810029340065LF/C293B0066T177552''-9083F82150280Human alpha-2-macroglobulin mRNA; 3' end {IM488103}

    022O44982275-1.2-2.41530791100373991815572.810029340065LF/C293B0066T177552''-9184G1021C0281Human alpha-1-antichymotrypsin mRNA; 3' {IM488360}

    022O449894382.91.423393125.410016679809730.310029340065LF/C293B0066T177552''-7839F122160267Human alpha-1 acid glycoprotein mRNA; co {IM429925}

    022O449895101.6-1.3523730.4986806330413.19829340065LF/C293B0066T177552''-8127F12021Z0270Human aldolase A mRNA; complete cds. {IM470436}

    022O449819384.22.1410022.49720009714.59729340065LF/C293B0066T177552''-7826E112160267Human aldehyde dehydrogenase I (ALDH-1) {IM429771}

    022O449898771.5-1.4238014.1100330216037.410029340065LF/C293B0066T177552''-9605B2021I0291Human 3-hydroxy-3-methylglutaryl CoA red {IM510196}

    022O449812001.6-1.3309417.893401419498.29329340065LF/C293B0066T177552''-4873G112130234Human 14 kd lectin mRNA; complete cds. {IM301144}

    022O44988863??2642.3766443132.17629340065LF/C293B0066T177552''-5548H2021O0241Human 1;2-cyclic-inositol-phosphate phos {IM328683}

    022O449849401.1-1.95443.99110405052.99129340065LF/C293B0066T177552''-9839E8021W0293G0/G1 SWITCH REGULATORY PROTEIN 8 {IM512498}

    022O449847211.7-1.226861144.6100323581570860.310029340065LF/C293B0066T177552''-8969E2021Q0279EUKARYOTIC INITIATION FACTOR 4 GAMMA {IM487212}

    022O449850491.3-1.54012.6656203011.96529340065LF/C293B0066T177552''-202B12100180ESTs {IM71001}

    022O449824311.5-1.4223610.7100306514885.810029340065LF/C293B0066T177552''-9808C1021W0293ESTs {IM510536}

    022O44987421-1.3-2.63143838173972.68329340065LF/C293B0066T177552''-9776H5021P0292ESTs {IM510482}

    022O44984682-1.1-2.414568.2100344216717.310029340065LF/C293B0066T177552''-8807G8021C0277ESTs {IM486601}

    022O44982958??1321.8383681791.73829340065LF/C293B0066T177552''-1823A4021J0197ESTs {IM43958}

    022O449818331.7-1.240532298481023359.19829340065LF/C293B0066T177552''-7412C52.10E+264ESTs {IM417125}

    022O449843141.9-1.1247214100264712855.710029340065LF/C293B0066T177552''-7339E42170262ESTs {IM416831}

    022O449868144.42.1580529.510027371329610029340065LF/C293B0066T177552''-7350F32170262ESTs {IM416762}

    022O449842722.91.416229.710011535603.310029340065LF/C293B0066T177552''-7171G4021T0260ESTs {IM415326}

    022O449816882.61.3292919.296228611105.29629340065LF/C293B0066T177552''-6834C32100257ESTs {IM376386}

    022O449889972.81.31289169.61009607466419.110029340065LF/C293B0066T177552''-6081D62180249ESTs {IM357967}

    022O449889781.4-1.5402619.8946064294411.79429340065LF/C293B0066T177552''-6007F42110248ESTs {IM357179}

    022O449834251.9-1.123610122.7100252631226449.710029340065LF/C293B0066T177552''-3688E22150216ESTs {IM269320}

    022O44988894.52.2177910.6788093932.47829340065LF/C293B0066T177552''-3543A1021Y0215ESTs {IM258761}

    022O44988158-1.2-2.48164.785193493948529340065LF/C293B0066T177552''-2630D8021S0205ESTs {IM198384}

    022O449878402-1.1554330.31005831283112.110029340065LF/C293B0066T177552''-1359B8021K0192ESTs {IM136101}

    022O449826403.51.7361219.7100211710284.510029340065LF/C293B0066T177552''-553G4021L0183ESTs {IM114101}

    022O449825565.92.928969161.910010153492920.710029340065LF/C293B0066T177552''-217C42100180EST {IM71410}

    022O449897201.3-1.6886050.810013880673825.510029340065LF/C293B0066T177552''-8967D12021Q0279ENDOTHELIAL ACTIN-BINDING PROTEIN {IM487418}

    022O449814604.32.1707746.4100340116518.110029340065LF/C293B0066T177552''-5922G3021U0247citrate synthase precursor (EC 4.1.3.7) {IM347719}

    022O449872861.8-1.24478241005234254110.310029340065LF/C293B0066T177552''-9230B11021J0282brain-expressed HHCPA78 homolog [Human; {IM488488}

    022O449815092.91.428696187.310020144977942.310029340065LF/C293B0066T177552''-6116G52180249beta 2-glycoprotein I [Human; HepG2 hepa {IM358822}

    022Q3614953613.922.81146650.91005038253.1100293Y0055Control 1(LF/C)293C0061TSA''-8239H42160271STROMELYSIN-3 PRECURSOR {IM471174}

    022Q36144035-6.7-4.17695.6913160518014.691293Y0055Control 1(LF/C)293C0061TSA''-6217G10021N0250mss4=Zn2+ binding protein/guanine nucleo {IM359769}

    022Q36148335-9.6-5.92972.592174528608.892293Y0055Control 1(LF/C)293C0061TSA''-3340H2021D0212METALLOTHIONEIN-IF {IM245990}

    022Q361486321.11.7325218.4100187530749.3100293Y0055Control 1(LF/C)293C0061TSA''-4618B8021P0232LYSOZYME C PRECURSOR {IM293925}

    022Q3614206311.7396417100231237909.7100293Y0055Control 1(LF/C)293C0061TSA''-8328G9021D0272IEX-1=radiation-inducible immediate-earl {IM471556}

    022Q3614885511.7226411.9100133821946.2100293Y0055Control 1(LF/C)293C0061TSA''-5508D10021O0241Human tryptophan oxygenase (TDO) mRNA; c {IM327488}

    022Q361498763.15.1648133.6100127920966.6100293Y0055Control 1(LF/C)293C0061TSA''-9591H12021B0290Human transformation-related protein mRNA {IM509889}

    022Q36147236-4.6-2.812047.11003400557316.6100293Y0055Control 1(LF/C)293C0061TSA''-9034B72150280Human ribosomal protein L39 mRNA; comple {IM487908}

    022Q36147145-1.11.59704.48864210523.188293Y0055Control 1(LF/C)293C0061TSA''-8672D52150276Human prolactin receptor-associated prot {IM486070}

    022Q361433252.54.1571132.9100139322837.1100293Y0055Control 1(LF/C)293C0061TSA''-3284C6021D0212Human phenylalanine hydroxylase (PAH) mu {IM243196}

    022Q3614416711.6654141.9903974651418.990293Y0055Control 1(LF/C)293C0061TSA''-6745C10021T0256Human nucleotide-binding protein mRNA; c {IM376052}

    022Q36141528-1.21.3105459478912943.994293Y0055Control 1(LF/C)293C0061TSA''-6190E7021N0250Human mRNA for SM22 alpha; complete cds. {IM359457}

    022Q361471493.15.119069.6843716092.484293Y0055Control 1(LF/C)293C0061TSA''-8692F12150276Human mRNA for RTP; complete cds. {IM486202}

    022Q36144026-1.51.1577536.6935112838025.293293Y0055Control 1(LF/C)293C0061TSA''-6187E4021N0250Human mRNA for plasma gelsolin. {IM359675}

    022Q36145145-3.1-1.916029.798303749781698293Y0055Control 1(LF/C)293C0061TSA''-586B1021S0184Human mRNA for placental leucine aminope {IM115166}

    022Q36146428-2.5-1.510985.4100166227247.4100293Y0055Control 1(LF/C)293C0061TSA''-5798D11021N0246Human mRNA for heparan sulfate proteagly {IM346135}

    022Q36146370-1.9-1.23762.5784477332.778293Y0055Control 1(LF/C)293C0061TSA''-5574B32190244Human mRNA for gravin; complete cds. {IM343061}

    022Q36141226-2-1.26323.510078612883.8100293Y0055Control 1(LF/C)293C0061TSA''-4985A3021H0236Human mRNA for fungal sterol-C5-desatura {IM305890}

    022Q36142236-4.1-2.55443.488137022466.388293Y0055Control 1(LF/C)293C0061TSA''-9022A72150280Human mRNA for CAB1; complete cds. {IM487763}

    022Q361422113.25.3412018.310078312844.1100293Y0055Control 1(LF/C)293C0061TSA''-8924A5021Q0279Human mRNA for ATP synthase subunit c en {IM487373}

    022Q361470933.15.2416816.310080813253.9100293Y0055Control 1(LF/C)293C0061TSA''-8460B9021R0274Human mRNA for annexin IV (carbohydrate- {IM485221}

    022Q361438281.11.8273017.398150124607.398293Y0055Control 1(LF/C)293C0061TSA''-5394C4021H0240Human metalloprotease/disintegrin/cystei {IM324266}

    022Q3614444-7.6-4.720459.210095311562533.7100293Y0055Control 1(LF/C)293C0061TSA''-1758C11021C0196Human insulin-like growth factor binding {IM158337}

    022Q36147227-3.1-1.9234512.31004465732020.8100293Y0055Control 1(LF/C)293C0061TSA''-9004H1021Q0279Human homolog of Yeast IPP isomerase. {IM487909}

    022Q36144690-12.2-7.42262.674168027548.674293Y0055Control 1(LF/C)293C0061TSA''-8835A12021J0278Human heterogenous nuclear RNA W16W. {IM486758}

    022Q36149908-1.31.3405323.81003220527816100293Y0055Control 1(LF/C)293C0061TSA''-9727D4021P0292Human hepatic squalene synthetase mRNA; {IM510298}

    022Q361476771.224223.275209342275293Y0055Control 1(LF/C)293C0061TSA''-711D6021Z0185Human glucose-6-phosphatase mRNA; comple {IM124592}

    022Q36149736-8.6-5.3209812.2100110291808046.4100293Y0055Control 1(LF/C)293C0061TSA''-9035B82150280Human G9 gene encoding sialidase. {IM487925}

    022Q36143359-14-8.510336.910088171445435.3100293Y0055Control 1(LF/C)293C0061TSA''-3424G2021K0213Human clone 137308 mRNA {IM252491}

    022Q3614630-10.7-6.519188.5100125592058844.9100293Y0055Control 1(LF/C)293C0061TSA''-2501A11021L0204Human chromosome 11 cosmid A9 including {IM187563}

    022Q36147575.18.41140829.797136622404.397293Y0055Control 1(LF/C)293C0061TSA''-3015E1021K0209Human ceruloplasmin mRNA. {IM223350}

    022Q36141307-1.6-18884.46389114603.863293Y0055Control 1(LF/C)293C0061TSA''-5303C92120239Human cellular retinol-binding protein m {IM322797}

    022Q36148397-2.3-1.416389.91002307378211.1100293Y0055Control 1(LF/C)293C0061TSA''-3584D6021Y0215Human CDw40 mRNA for nerve growth factor {IM261517}

    022Q36141144-8.5-5.24233.174220036079.374293Y0055Control 1(LF/C)293C0061TSA''-4653E7021P0232Human betaine:homocysteine methyltransfe {IM294688}

    022Q361472115.38.8785835.210089714704.5100293Y0055Control 1(LF/C)293C0061TSA''-8936B5021Q0279Human beta-migrating plasminogen activat {IM487394}

    022Q361465971.11.8494627.61002777455213100293Y0055Control 1(LF/C)293C0061TSA''-6484F12180253Human apolipoprotein C-III (apoC-III) mR {IM364983}

    022Q361432864.37.131676150.41004460731218.4100293Y0055Control 1(LF/C)293C0061TSA''-3122E12021Z0210Human ApoH mRNA for apolipoprotein H (be {IM234212}

    022Q36149748-11.6814844.81005059829421.5100293Y0055Control 1(LF/C)293C0061TSA''-9083F82150280Human alpha-2-macroglobulin mRNA; 3' end {IM488103}

    022Q361422751.93.1576827.5100185030328.9100293Y0055Control 1(LF/C)293C0061TSA''-9184G1021C0281Human alpha-1-antichymotrypsin mRNA; 3' {IM488360}

    022Q361494383.25.3882245.3100166527308.7100293Y0055Control 1(LF/C)293C0061TSA''-7839F122160267Human alpha-1 acid glycoprotein mRNA; co {IM429925}

    022Q36149510-2.8-1.7203110.61003466568214.5100293Y0055Control 1(LF/C)293C0061TSA''-8127F12021Z0270Human aldolase A mRNA; complete cds. {IM470436}

    022Q361419381.32.118849.59491915074.894293Y0055Control 1(LF/C)293C0061TSA''-7826E112160267Human aldehyde dehydrogenase I (ALDH-1) {IM429771}

    022Q36149877-1.7-1229611.71002340383611.3100293Y0055Control 1(LF/C)293C0061TSA''-9605B2021I0291Human 3-hydroxy-3-methylglutaryl CoA red {IM510196}

    022Q36141200-7.9-4.815899.310076221249531.8100293Y0055Control 1(LF/C)293C0061TSA''-4873G112130234Human 14 kd lectin mRNA; complete cds. {IM301144}

    022Q36148863??2552.450229375250293Y0055Control 1(LF/C)293C0061TSA''-5548H2021O0241Human 1;2-cyclic-inositol-phosphate phos {IM328683}

    022Q36144940-1.612853.1712764522.471293Y0055Control 1(LF/C)293C0061TSA''-9839E8021W0293G0/G1 SWITCH REGULATORY PROTEIN 8 {IM512498}

    022Q361447215.18.3490128.8925909683.892293Y0055Control 1(LF/C)293C0061TSA''-8969E2021Q0279EUKARYOTIC INITIATION FACTOR 4 GAMMA {IM487212}

    022Q36145049-11.64742.956293481256293Y0055Control 1(LF/C)293C0061TSA''-202B12100180ESTs {IM71001}

    022Q361424313.15.2162610.1833155172.583293Y0055Control 1(LF/C)293C0061TSA''-9808C1021W0293ESTs {IM510536}

    022Q36147421-5.5-3.45803.494194531888.794293Y0055Control 1(LF/C)293C0061TSA''-9776H5021P0292ESTs {IM510482}

    022Q36144682-1.21.46664.5794888003.179293Y0055Control 1(LF/C)293C0061TSA''-8807G8021C0277ESTs {IM486601}

    022Q36142958??1631.9521622661.652293Y0055Control 1(LF/C)293C0061TSA''-1823A4021J0197ESTs {IM43958}

    022Q36141833-2.3-1.4235011.31003337547113.9100293Y0055Control 1(LF/C)293C0061TSA''-7412C52.10E+264ESTs {IM417125}

    022Q36144314-15.1-9.24493.7904141678820.290293Y0055Control 1(LF/C)293C0061TSA''-7339E42170262ESTs {IM416831}

    022Q36146814-1.41.2284810.7100238039028.8100293Y0055Control 1(LF/C)293C0061TSA''-7350F32170262ESTs {IM416762}

    022Q36144272-1.7-1.111897.765124920476.865293Y0055Control 1(LF/C)293C0061TSA''-7171G4021T0260ESTs {IM415326}

    022Q36141688-2.3-1.411235.6100154125276.4100293Y0055Control 1(LF/C)293C0061TSA''-6834C32100257ESTs {IM376386}

    022Q3614899711.7498727.51002963485814.5100293Y0055Control 1(LF/C)293C0061TSA''-6081D62180249ESTs {IM357967}

    022Q36148978-1.8-1.112246.184134121986.284293Y0055Control 1(LF/C)293C0061TSA''-6007F42110248ESTs {IM357179}

    022Q361434252.33.81804093.51004774782720.1100293Y0055Control 1(LF/C)293C0061TSA''-3688E22150216ESTs {IM269320}

    022Q3614889-2.2-1.46723.56491715044.264293Y0055Control 1(LF/C)293C0061TSA''-3543A1021Y0215ESTs {IM258761}

    022Q36148158-1.41.15693.8885028233.188293Y0055Control 1(LF/C)293C0061TSA''-2630D8021S0205ESTs {IM198384}

    022Q36147840-1.9-1.2387026.8914591752624.291293Y0055Control 1(LF/C)293C0061TSA''-1359B8021K0192ESTs {IM136101}

    022Q3614264023.3435122.191131021475.791293Y0055Control 1(LF/C)293C0061TSA''-553G4021L0183ESTs {IM114101}

    022Q3614255623.226089136.96281291332632.762293Y0055Control 1(LF/C)293C0061TSA''-217C42100180EST {IM71410}

    022Q361497204.47.2430623.5945979783.794293Y0055Control 1(LF/C)293C0061TSA''-8967D12021Q0279ENDOTHELIAL ACTIN-BINDING PROTEIN {IM487418}

    022Q36141460-1.41.2469517.11003994654714.8100293Y0055Control 1(LF/C)293C0061TSA''-5922G3021U0247citrate synthase precursor (EC 4.1.3.7) {IM347719}

    022Q36147286-8.5-5.216098.610083481368638.8100293Y0055Control 1(LF/C)293C0061TSA''-9230B11021J0282brain-expressed HHCPA78 homolog [Human; {IM488488}

    022Q361415093.76.12716693.71004467732316100293Y0055Control 1(LF/C)293C0061TSA''-6116G52180249beta 2-glycoprotein I [Human; HepG2 hepa {IM358822}

    022X361595361.11.3749922.31005599708714.3100293Y0055Control 1(LF/C)29350060T020883''-8239H42160271STROMELYSIN-3 PRECURSOR {IM471174}

    022X36154035-1.21.113227.688120415244.588293Y0055Control 1(LF/C)29350060T020883''-6217G10021N0250mss4=Zn2+ binding protein/guanine nucleo {IM359769}

    022X36158335??4312.4915456902.491293Y0055Control 1(LF/C)29350060T020883''-3340H2021D0212METALLOTHIONEIN-IF {IM245990}

    022X36158632-1.11.2465619.8943929497312.194293Y0055Control 1(LF/C)29350060T020883''-4618B8021P0232LYSOZYME C PRECURSOR {IM293925}

    022X361520631.41.72232261.5100128851631031.9100293Y0055Control 1(LF/C)29350060T020883''-8328G9021D0272IEX-1=radiation-inducible immediate-earl {IM471556}

    022X36158855-1.21281210100269034057.8100293Y0055Control 1(LF/C)29350060T020883''-5508D10021O0241Human tryptophan oxygenase (TDO) mRNA; c {IM327488}

    022X36159876-1.21.1392213.61003605456311.3100293Y0055Control 1(LF/C)29350060T020883''-9591H12021B0290Human transformation-related protein mRNA {IM509889}

    022X36157236-2.4-1.916346.21003140397510100293Y0055Control 1(LF/C)29350060T020883''-9034B72150280Human ribosomal protein L39 mRNA; comple {IM487908}

    022X36157145-1.3-1.11113495118314973.895293Y0055Control 1(LF/C)29350060T020883''-8672D52150276Human prolactin receptor-associated prot {IM486070}

    022X36153325-1.3-1.1321815.41003414432110.6100293Y0055Control 1(LF/C)29350060T020883''-3284C6021D0212Human phenylalanine hydroxylase (PAH) mu {IM243196}

    022X36154167-1.21.1755633.6896952880020.589293Y0055Control 1(LF/C)29350060T020883''-6745C10021T0256Human nucleotide-binding protein mRNA; c {IM376052}

    022X36151528-1.4-1.128436.9100303438406.6100293Y0055Control 1(LF/C)29350060T020883''-6190E7021N0250Human mRNA for SM22 alpha; complete cds. {IM359457}

    022X36157149-1.3-118436.4100188723886100293Y0055Control 1(LF/C)29350060T020883''-8692F12150276Human mRNA for RTP; complete cds. {IM486202}

    022X36154026-1.4-1.1623130.7896762856020.689293Y0055Control 1(LF/C)29350060T020883''-6187E4021N0250Human mRNA for plasma gelsolin. {IM359675}

    022X36155145-1.11.25220161004452563511100293Y0055Control 1(LF/C)29350060T020883''-586B1021S0184Human mRNA for placental leucine aminope {IM115166}

    022X36156428-1.21.128677.3100265133566.8100293Y0055Control 1(LF/C)29350060T020883''-5798D11021N0246Human mRNA for heparan sulfate proteagly {IM346135}

    022X361563701.31.68352.9925196572.192293Y0055Control 1(LF/C)29350060T020883''-5574B32190244Human mRNA for gravin; complete cds. {IM343061}

    022X36151226-2.1-1.720846.2100351344478.8100293Y0055Control 1(LF/C)29350060T020883''-4985A3021H0236Human mRNA for fungal sterol-C5-desatura {IM305890}

    022X36152236-2.8-2.215795.9100344043548.8100293Y0055Control 1(LF/C)29350060T020883''-9022A72150280Human mRNA for CAB1; complete cds. {IM487763}

    022X361522111.31.71267437.2967681972319.396293Y0055Control 1(LF/C)29350060T020883''-8924A5021Q0279Human mRNA for ATP synthase subunit c en {IM487373}

    022X36157093-1.4-1.1349311.11003989504911100293Y0055Control 1(LF/C)29350060T020883''-8460B9021R0274Human mRNA for annexin IV (carbohydrate- {IM485221}

    022X3615382811.3278913.198219127737.398293Y0055Control 1(LF/C)29350060T020883''-5394C4021H0240Human metalloprotease/disintegrin/cystei {IM324266}

    022X3615444-1.3-125047.3100257232566.5100293Y0055Control 1(LF/C)29350060T020883''-1758C11021C0196Human insulin-like growth factor binding {IM158337}

    022X36157227-2.3-1.8302810.41005490694917.1100293Y0055Control 1(LF/C)29350060T020883''-9004H1021Q0279Human homolog of Yeast IPP isomerase. {IM487909}

    022X36154690-1.3-16133.9836197842.783293Y0055Control 1(LF/C)29350060T020883''-8835A12021J0278Human heterogenous nuclear RNA W16W. {IM486758}

    022X36159908-2.4-1.9384313.51007236915923.9100293Y0055Control 1(LF/C)29350060T020883''-9727D4021P0292Human hepatic squalene synthetase mRNA; {IM510298}

    022X36157677-11.39424.4937509493.193293Y0055Control 1(LF/C)29350060T020883''-711D6021Z0185Human glucose-6-phosphatase mRNA; comple {IM124592}

    022X36159736-1.3-1.1295310.5100313939739.3100293Y0055Control 1(LF/C)29350060T020883''-9035B82150280Human G9 gene encoding sialidase. {IM487925}

    022X36153359-1.21.110774909971262390293Y0055Control 1(LF/C)29350060T020883''-3424G2021K0213Human clone 137308 mRNA {IM252491}

    022X3615630-1.5-1.2508117.11006135776615.3100293Y0055Control 1(LF/C)29350060T020883''-2501A11021L0204Human chromosome 11 cosmid A9 including {IM187563}

    022X3615757-1.11.12944551.191262303320245.691293Y0055Control 1(LF/C)29350060T020883''-3015E1021K0209Human ceruloplasmin mRNA. {IM223350}

    022X36151307-1.4-1.118105.567198225095.167293Y0055Control 1(LF/C)29350060T020883''-5303C92120239Human cellular retinol-binding protein m {IM322797}

    022X3615839711.3494322.21003797480611.1100293Y0055Control 1(LF/C)29350060T020883''-3584D6021Y0215Human CDw40 mRNA for nerve growth factor {IM261517}

    022X36151144-1.3-15552.8715827372.471293Y0055Control 1(LF/C)29350060T020883''-4653E7021P0232Human betaine:homocysteine methyltransfe {IM294688}

    022X361572111.21.61042931.81006676845018.3100293Y0055Control 1(LF/C)29350060T020883''-8936B5021Q0279Human beta-migrating plasminogen activat {IM487394}

    022X36156597-1.4-1.1640519.21007063894117.9100293Y0055Control 1(LF/C)29350060T020883''-6484F12180253Human apolipoprotein C-III (apoC-III) mR {IM364983}

    022X36153286-1.9-1.51301157.1100193702451956.6100293Y0055Control 1(LF/C)29350060T020883''-3122E12021Z0210Human ApoH mRNA for apolipoprotein H (be {IM234212}

    022X36159748-1.31958435.710095431208024.5100293Y0055Control 1(LF/C)29350060T020883''-9083F82150280Human alpha-2-macroglobulin mRNA; 3' end {IM488103}

    022X361522751.11.41936257.4100141981797235100293Y0055Control 1(LF/C)29350060T020883''-9184G1021C0281Human alpha-1-antichymotrypsin mRNA; 3' {IM488360}

    022X36159438-1.21832229.410080821023022.4100293Y0055Control 1(LF/C)29350060T020883''-7839F122160267Human alpha-1 acid glycoprotein mRNA; co {IM429925}

    022X36159510-1.11.1409914.3893578452911.189293Y0055Control 1(LF/C)29350060T020883''-8127F12021Z0270Human aldolase A mRNA; complete cds. {IM470436}

    022X36151938-1.6-1.3452314.61005874743615.1100293Y0055Control 1(LF/C)29350060T020883''-7826E112160267Human aldehyde dehydrogenase I (ALDH-1) {IM429771}

    022X36159877-2.1-1.726429.41004385555113.4100293Y0055Control 1(LF/C)29350060T020883''-9605B2021I0291Human 3-hydroxy-3-methylglutaryl CoA red {IM510196}

    022X36151200-1.3-1323311.49232454107892293Y0055Control 1(LF/C)29350060T020883''-4873G112130234Human 14 kd lectin mRNA; complete cds. {IM301144}

    022X36158863??3392.272359455272293Y0055Control 1(LF/C)29350060T020883''-5548H2021O0241Human 1;2-cyclic-inositol-phosphate phos {IM328683}

    022X36154940-1.5-1.24963.3805847392.780293Y0055Control 1(LF/C)29350060T020883''-9839E8021W0293G0/G1 SWITCH REGULATORY PROTEIN 8 {IM512498}

    022X36154721-11.2688232.696568872001796293Y0055Control 1(LF/C)29350060T020883''-8969E2021Q0279EUKARYOTIC INITIATION FACTOR 4 GAMMA {IM487212}

    022X36155049-2.7-2.215084.884324541076.684293Y0055Control 1(LF/C)29350060T020883''-202B12100180ESTs {IM71001}

    022X361524311.11.4339112100249631597.3100293Y0055Control 1(LF/C)29350060T020883''-9808C1021W0293ESTs {IM510536}

    022X361574211.11.49423.8916888712.991293Y0055Control 1(LF/C)29350060T020883''-9776H5021P0292ESTs {IM510482}

    022X36154682-1.2110245.986100612743.886293Y0055Control 1(LF/C)29350060T020883''-8807G8021C0277ESTs {IM486601}

    022X36152958??3842.4484355502.248293Y0055Control 1(LF/C)29350060T020883''-1823A4021J0197ESTs {IM43958}

    022X36151833-2.6-2.1616320.6100128531627032.4100293Y0055Control 1(LF/C)29350060T020883''-7412C52.10E+264ESTs {IM417125}

    022X36154314-1.3-19024.48194511963.781293Y0055Control 1(LF/C)29350060T020883''-7339E42170262ESTs {IM416831}

    022X36156814-1.5-1.2602412.51007253918115.6100293Y0055Control 1(LF/C)29350060T020883''-7350F32170262ESTs {IM416762}

    022X36154272-2.7-2.116988.179359445491179293Y0055Control 1(LF/C)29350060T020883''-7171G4021T0260ESTs {IM415326}

    022X36151688-2-1.630389.11004915622212.3100293Y0055Control 1(LF/C)29350060T020883''-6834C32100257ESTs {IM376386}

    022X36158997-1.21.11073348.510097811238128.9100293Y0055Control 1(LF/C)29350060T020883''-6081D62180249ESTs {IM357967}

    022X3615897811.314745.798114614513.898293Y0055Control 1(LF/C)29350060T020883''-6007F42110248ESTs {IM357179}

    022X361534251.11.31250561.18893501183627.688293Y0055Control 1(LF/C)29350060T020883''-3688E22150216ESTs {IM269320}

    022X3615889-1.21.111314.387106813523.287293Y0055Control 1(LF/C)29350060T020883''-3543A1021Y0215ESTs {IM258761}

    022X36158158-1.21.112755.19611981517496293Y0055Control 1(LF/C)29350060T020883''-2630D8021S0205ESTs {IM198384}

    022X36157840-1.21742331.8887167907221.388293Y0055Control 1(LF/C)29350060T020883''-1359B8021K0192ESTs {IM136101}

    022X36152640-1.21.1287612.575269634137.775293Y0055Control 1(LF/C)29350060T020883''-553G4021L0183ESTs {IM114101}

    022X36152556-1.3-125958100.859260463297064.559293Y0055Control 1(LF/C)29350060T020883''-217C42100180EST {IM71410}

    022X361597201.21.6510515.7100326041269.4100293Y0055Control 1(LF/C)29350060T020883''-8967D12021Q0279ENDOTHELIAL ACTIN-BINDING PROTEIN {IM487418}

    022X36151460-1.5-1.22149653.9100261553310858.9100293Y0055Control 1(LF/C)29350060T020883''-5922G3021U0247citrate synthase precursor (EC 4.1.3.7) {IM347719}

    022X36157286-1.11.2272210.4100234929738.1100293Y0055Control 1(LF/C)29350060T020883''-9230B11021J0282brain-expressed HHCPA78 homolog [Human; {IM488488}

    022X36151509-1.11.153047118.6100463805870997.7100293Y0055Control 1(LF/C)29350060T020883''-6116G52180249beta 2-glycoprotein I [Human; HepG2 hepa {IM358822}

  • Optimization with ArraysExpression ProfileTarget

    Chart1

    50.2-0.53.72.44.93.8008.2-0.36.4-0.8-7.37.54.3-21.80.40.90.20.40.4-0.44.2-0.3-4.3-2.10.41.50.2-4.11.8-0.1-4.20-4.34.2-0.60.93.1-2.3-7.8-0.70.1-4.1-7.45.5-0.1-6.20.7-4.2-0.20.5-0.6-0.7-0.7-0.6-0.2-0.80.1-1.1-2.2-0.7-2.8-6.1-5.1-1-3.1TSATSA

    40.2-0.100.10.3-0.210.40.20.10-0.9-0.7-0.10.1-0.71.11.5-0.70.10.8-0.50.20.8-0.1-0.5-0.71.50.9-0.30.9-0.301-0.3-0.720.7-1.1-0.7-0.5-0.9-0.9-0.3-0.2-0.1-0.2-0.6-0.7-0.10.10-0.7-0.3-0.7-0.7000.90.20-0.2-0.70.10.1-0.50LeadLead

    1289.85.73.33.255.14.51.64.210.40.30.70.200.10.80-0.10.1-0.200.2-0.100.31.1-0.10.50.10.3-0.3-0.2-0.80.1-0.40.10.2-0.3-0.5-0.50.2-0.4-0.4-0.3-0.6-1-0.2-0.3-0.4-0.9-0.4-0.3-0.2-0.6-0.5-1-0.5-2.3-1.9-0.5-1.6-2-2.1-2.4-2.4OptimizedOptimized

    149.66.554.83.33.12.42110.90.80.40.40.30.20.20.20.10.10.10.10.10.10000000-0.1-0.1-0.1-0.1-0.2-0.2-0.2-0.2-0.3-0.3-0.3-0.4-0.4-0.5-0.5-0.5-0.6-0.6-0.6-0.7-0.7-0.7-0.7-0.8-1-1.2-1.2-1.3-1.3-1.4-1.6-1.8-2.1-2.2-2.2-2.4ToxinToxin

    153.30.90.81.60.70.30.90.50.10.1-0.1-0.10.2-0.20.10.80.2-0.20.1-1.2-0.31.4-0.2-0.1-0.41.40.3-0.90.1-0.1-0.61.40.40.40.70.20.50.1-0.4-0.70.40.50.5-0.1-0.3-0.7-1.10.60.3-1-1.1-1.1-0.31.6-0.3-0.2-1.1-1.8-0.4-1.1-1.9-1.10.10-0.4-1.8-1.7Best DrugBest Drug

    Gene Index

    Differential Expression

    Chart2

    1010-0.60.10-0.4100.20.100.10-0.3-0.2-0.10.1-0.31.10.80-0.10.6000.90-0.4-0.31.20.700.9-0.1-0.40.7-0.7-0.21.2-0.2-0.1-0.1-0.6-0.2-0.3-0.1-0.10.20.1-0.6-0.10.10.2-0.1-0.1-0.7-0.100.20.11.10.300-0.30.5-0.1-0.30.1

    440.2-0.100.10.3-0.210.40.20.10-0.9-0.7-0.10.1-0.71.11.5-0.70.10.8-0.50.20.8-0.1-0.5-0.71.50.9-0.30.9-0.301-0.3-0.720.7-1.1-0.7-0.5-0.9-0.9-0.3-0.2-0.1-0.2-0.6-0.7-0.10.10-0.7-0.3-0.7-0.7000.90.20-0.2-0.70.10.1-0.50

    121289.85.73.33.255.14.51.64.210.40.30.70.200.10.80-0.10.1-0.200.2-0.100.31.1-0.10.50.10.3-0.3-0.2-0.80.1-0.40.10.2-0.3-0.5-0.50.2-0.4-0.4-0.3-0.6-1-0.2-0.3-0.4-0.9-0.4-0.3-0.2-0.6-0.5-1-0.5-2.3-1.9-0.5-1.6-2-2.1-2.4-2.4

    14149.66.554.83.33.12.42110.90.80.40.40.30.20.20.20.10.10.10.10.10.10000000-0.1-0.1-0.1-0.1-0.2-0.2-0.2-0.2-0.3-0.3-0.3-0.4-0.4-0.5-0.5-0.5-0.6-0.6-0.6-0.7-0.7-0.7-0.7-0.8-1-1.2-1.2-1.3-1.3-1.4-1.6-1.8-2.1-2.2-2.2-2.4

    15153.30.90.81.60.70.30.90.50.10.1-0.1-0.10.2-0.20.10.80.2-0.20.1-1.2-0.31.4-0.2-0.1-0.41.40.3-0.90.1-0.1-0.61.40.40.40.70.20.50.1-0.4-0.70.40.50.5-0.1-0.3-0.7-1.10.60.3-1-1.1-1.1-0.31.6-0.3-0.2-1.1-1.8-0.4-1.1-1.9-1.10.10-0.4-1.8-1.7

    Gene Index

    Differential Expression

    Chart3

    1010-0.60.10-0.4100.20.100.10-0.3-0.2-0.10.1-0.31.10.80-0.10.6000.90-0.4-0.31.20.700.9-0.1-0.40.7-0.7-0.21.2-0.2-0.1-0.1-0.6-0.2-0.3-0.1-0.10.20.1-0.6-0.10.10.2-0.1-0.1-0.7-0.100.20.11.10.300-0.30.5-0.1-0.30.1

    440.2-0.100.10.3-0.210.40.20.10-0.9-0.7-0.10.1-0.71.11.5-0.70.10.8-0.50.20.8-0.1-0.5-0.71.50.9-0.30.9-0.301-0.3-0.720.7-1.1-0.7-0.5-0.9-0.9-0.3-0.2-0.1-0.2-0.6-0.7-0.10.10-0.7-0.3-0.7-0.7000.90.20-0.2-0.70.10.1-0.50

    121289.85.73.33.255.14.51.64.210.40.30.70.200.10.80-0.10.1-0.200.2-0.100.31.1-0.10.50.10.3-0.3-0.2-0.80.1-0.40.10.2-0.3-0.5-0.50.2-0.4-0.4-0.3-0.6-1-0.2-0.3-0.4-0.9-0.4-0.3-0.2-0.6-0.5-1-0.5-2.3-1.9-0.5-1.6-2-2.1-2.4-2.4

    14149.66.554.83.33.12.42110.90.80.40.40.30.20.20.20.10.10.10.10.10.10000000-0.1-0.1-0.1-0.1-0.2-0.2-0.2-0.2-0.3-0.3-0.3-0.4-0.4-0.5-0.5-0.5-0.6-0.6-0.6-0.7-0.7-0.7-0.7-0.8-1-1.2-1.2-1.3-1.3-1.4-1.6-1.8-2.1-2.2-2.2-2.4

    16163.30.90.81.60.70.30.90.50.10.1-0.1-0.10.2-0.20.10.80.2-0.20.1-1.2-0.31.4-0.2-0.1-0.41.40.3-0.90.1-0.1-0.61.40.40.40.70.20.50.1-0.4-0.70.40.50.5-0.1-0.3-0.7-1.10.60.3-1-1.1-1.1-0.31.6-0.3-0.2-1.1-1.8-0.4-1.1-1.9-1.10.10-0.4-1.8-1.7

    550.2-0.53.72.44.93.8008.2-0.36.4-0.8-7.37.54.3-21.80.40.90.20.40.4-0.44.2-0.3-4.3-2.10.41.50.2-4.11.8-0.1-4.20-4.34.2-0.60.93.1-2.3-7.8-0.70.1-4.1-7.45.5-0.1-6.20.7-4.2-0.20.5-0.6-0.7-0.7-0.6-0.2-0.80.1-1.1-2.2-0.7-2.8-6.1-5.1-1-3.1

    Gene Index

    Differential Expression (fold change)

    Sheet2

    ABCDEF

    1041214165

    1041214165

    -0.60.289.63.30.2

    0.1-0.19.86.50.9-0.5

    005.750.83.7

    -0.40.13.34.81.62.4

    10.33.23.30.74.9

    0-0.253.10.33.8

    0.215.12.40.90

    0.10.44.520.50

    00.21.610.18.2

    0.10.14.210.1-0.3

    0010.9-0.16.4

    -0.3-0.90.40.8-0.1-0.8

    -0.2-0.70.30.40.2-7.3

    -0.1-0.10.70.4-0.27.5

    0.10.10.20.30.14.3

    -0.3-0.700.20.8-21.8

    1.11.10.10.20.20.4

    0.81.50.80.2-0.20.9

    0-0.700.10.10.2

    -0.10.1-0.10.1-1.20.4

    0.60.80.10.1-0.30.4

    0-0.5-0.20.11.4-0.4

    00.200.1-0.24.2

    0.90.80.20.1-0.1-0.3

    0-0.1-0.10-0.4-4.3

    -0.4-0.5001.4-2.1

    -0.3-0.70.300.30.4

    1.21.51.10-0.91.5

    0.70.9-0.100.10.2

    0-0.30.50-0.1-4.1

    0.90.90.10-0.61.8

    -0.1-0.30.3-0.11.4-0.1

    -0.40-0.3-0.10.4-4.2

    0.71-0.2-0.10.40

    -0.7-0.3-0.8-0.10.7-4.3

    -0.2-0.70.1-0.20.24.2

    1.22-0.4-0.20.5-0.6

    -0.20.70.1-0.20.10.9

    -0.1-1.10.2-0.2-0.43.1

    -0.1-0.7-0.3-0.3-0.7-2.3

    -0.6-0.5-0.5-0.30.4-7.8

    -0.2-0.9-0.5-0.30.5-0.7

    -0.3-0.90.2-0.40.50.1

    -0.1-0.3-0.4-0.4-0.1-4.1

    -0.1-0.2-0.4-0.5-0.3-7.4

    0.2-0.1-0.3-0.5-0.75.5

    0.1-0.2-0.6-0.5-1.1-0.1

    -0.6-0.6-1-0.60.6-6.2

    -0.1-0.7-0.2-0.60.30.7

    0.1-0.1-0.3-0.6-1-4.2

    0.20.1-0.4-0.7-1.1-0.2

    -0.10-0.9-0.7-1.10.5

    -0.1-0.7-0.4-0.7-0.3-0.6

    -0.7-0.3-0.3-0.71.6-0.7

    -0.1-0.7-0.2-0.8-0.3-0.7

    0-0.7-0.6-1-0.2-0.6

    0.20-0.5-1.2-1.1-0.2

    0.10-1-1.2-1.8-0.8

    1.10.9-0.5-1.3-0.40.1

    0.30.2-2.3-1.3-1.1-1.1

    00-1.9-1.4-1.9-2.2

    0-0.2-0.5-1.6-1.1-0.7

    -0.3-0.7-1.6-1.80.1-2.8

    0.50.1-2-2.10-6.1

    -0.10.1-2.1-2.2-0.4-5.1

    -0.3-0.5-2.4-2.2-1.8-1

    0.10-2.4-2.4-1.7-3.1

    Sheet1

    Genes022Q3614022X3615022I36182243616022B3617022O4498TSACompetitionLeadOptimizedToxinBest DrugToxin

    TARGET510412141514

    TARGET510412141514

    Human mRNA for gravin; complete cds. {IM343061}-1.21.6-1.2-6-10.6-4.30.2-0.60.289.63.39.6

    Human prolactin receptor-associated prot {IM486070}1.5-1.11.1-10.8-7.5-1.9-0.50.1-0.19.86.50.96.5

    Human insulin-like growth factor binding {IM158337}-4.7-11-6.7-6-1.83.7005.750.85

    ESTs {IM510482}-3.41.4-1.1-4.3-5.8-2.62.4-0.40.13.34.81.64.8

    METALLOTHIONEIN-IF {IM245990}-5.9-2-1.3-2.2-4.3-1.74.910.33.23.30.73.3

    Human 14 kd lectin mRNA; complete cds. {IM301144}-4.8-11.2-6-4.1-1.33.80-0.253.10.33.1

    G0/G1 SWITCH REGULATORY PROTEIN 8 {IM512498}1-1.2-2-6.1-3.4-1.900.215.12.40.92.4

    Human cellular retinol-binding protein m {IM322797}-1-1.1-1.4-5.5-3-1.500.10.44.520.52

    ESTs {IM416831}-9.2-1-1.2-2.6-2-1.18.200.21.610.11

    Human mRNA for SM22 alpha; complete cds. {IM359457}1.3-1.1-1.1-5.2-2-1.1-0.30.10.14.210.11

    Human heterogenous nuclear RNA W16W. {IM486758}-7.4-11-2-1.91.16.40010.9-0.10.9

    Human metalloprotease/disintegrin/cystei {IM324266}1.81.31.9-1.4-1.81.1-0.8-0.3-0.90.40.8-0.10.8

    EUKARYOTIC INITIATION FACTOR 4 GAMMA {IM487212}8.31.21.7-1.3-1.4-1.2-7.3-0.2-0.70.30.40.20.4

    Human clone 137308 mRNA {IM252491}-8.51.11.1-1.7-1.41.27.5-0.1-0.10.70.4-0.20.4

    Human G9 gene encoding sialidase. {IM487925}-5.3-1.1-1.1-1.2-1.3-1.14.30.10.10.20.30.10.3

    STROMELYSIN-3 PRECURSOR {IM471174}22.81.31.71-1.2-1.8-21.8-0.3-0.700.20.80.2

    ESTs {IM417125}-1.4-2.1-2.1-1.1-1.2-1.20.41.11.10.10.20.20.2

    Human homolog of Yeast IPP isomerase. {IM487909}-1.9-1.8-2.5-1.8-1.21.20.90.81.50.80.2-0.20.2

    ESTs {IM136101}-1.211.71-1.1-1.10.20-0.700.10.10.1

    ESTs {IM258761}-1.41.1-1.11.1-1.12.20.4-0.10.1-0.10.1-1.20.1

    ESTs {IM376386}-1.4-1.6-1.8-1.1-1.11.30.40.60.80.10.1-0.30.1

    ESTs {IM486601}1.411.51.2-1.1-2.4-0.40-0.5-0.20.11.40.1

    Human betaine:homocysteine methyltransfe {IM294688}-5.2-1-1.21-1.11.24.200.200.1-0.20.1

    Human hepatic squalene synthetase mRNA; {IM510298}1.3-1.9-1.8-1.2-1.11.1-0.30.90.80.20.1-0.10.1

    Human alpha-1 acid glycoprotein mRNA; co {IM429925}5.311.11.1-11.4-4.30-0.1-0.10-0.40

    Human alpha-1-antichymotrypsin mRNA; 3' {IM488360}3.11.41.5-11-2.4-2.1-0.4-0.5001.40

    Human CDw40 mRNA for nerve growth factor {IM261517}-1.41.31.7-1.31-1.30.4-0.3-0.70.300.30

    Human mRNA for CAB1; complete cds. {IM487763}-2.5-2.2-2.5-2.1-11.91.51.21.51.10-0.90

    Human mRNA for fungal sterol-C5-desatura {IM305890}-1.2-1.7-1.91.1-1-1.10.20.70.9-0.100.10

    Human mRNA for RTP; complete cds. {IM486202}5.1-11.3-1.5-11.1-4.10-0.30.50-0.10

    Human ribosomal protein L39 mRNA; comple {IM487908}-2.8-1.9-1.9-1.1-11.61.80.90.90.10-0.60

    ESTs {IM198384}1.11.11.3-1.31.1-2.4-0.1-0.1-0.30.3-0.11.4-0.1

    ESTs {IM510536}5.21.411.31.1-1.4-4.2-0.40-0.3-0.10.4-0.1

    Human 3-hydroxy-3-methylglutaryl CoA red {IM510196}-1-1.7-21.21.1-1.400.71-0.2-0.10.4-0.1

    Human mRNA for ATP synthase subunit c en {IM487373}5.31.71.31.81.1-1.7-4.3-0.7-0.3-0.8-0.10.7-0.1

    brain-expressed HHCPA78 homolog [Human; {IM488488}-5.21.21.7-1.11.2-1.24.2-0.2-0.70.1-0.20.2-0.2

    ESTs {IM71001}1.6-2.2-31.41.2-1.5-0.61.22-0.4-0.20.5-0.2

    Human mRNA for placental leucine aminope {IM115166}-1.91.2-1.7-1.11.2-1.10.9-0.20.70.1-0.20.1-0.2

    mss4=Zn2+ binding protein/guanine nucleo {IM359769}-4.11.12.1-1.21.21.43.1-0.1-1.10.2-0.2-0.4-0.2

    ESTs {IM114101}3.31.11.71.31.31.7-2.3-0.1-0.7-0.3-0.3-0.7-0.3

    Human beta-migrating plasminogen activat {IM487394}8.81.61.51.51.3-1.4-7.8-0.6-0.5-0.5-0.30.4-0.3

    LYSOZYME C PRECURSOR {IM293925}1.71.21.91.51.3-1.5-0.7-0.2-0.9-0.5-0.30.5-0.3

    ESTs {IM357179}-1.11.31.9-1.21.4-1.50.1-0.3-0.90.2-0.40.5-0.4

    Human transformation-related protein mRNA {IM509889}5.11.11.31.41.41.1-4.1-0.1-0.3-0.4-0.4-0.1-0.4

    Human ceruloplasmin mRNA. {IM223350}8.41.11.21.41.51.3-7.4-0.1-0.2-0.4-0.5-0.3-0.5

    Human chromosome 11 cosmid A9 including {IM187563}-6.5-1.21.11.31.51.75.50.2-0.1-0.3-0.5-0.7-0.5

    Human mRNA for plasma gelsolin. {IM359675}1.1-1.11.21.61.52.1-0.10.1-0.2-0.6-0.5-1.1-0.5

    ENDOTHELIAL ACTIN-BINDING PROTEIN {IM487418}7.21.61.621.6-1.6-6.2-0.6-0.6-1-0.60.6-0.6

    Human aldolase A mRNA; complete cds. {IM470436}-1.71.11.71.21.6-1.30.7-0.1-0.7-0.2-0.60.3-0.6

    Human mRNA for annexin IV (carbohydrate- {IM485221}5.2-1.11.11.31.62-4.20.1-0.1-0.3-0.6-1-0.6

    ESTs {IM416762}1.2-1.2-1.11.41.72.1-0.20.20.1-0.4-0.7-1.1-0.7

    Human mRNA for heparan sulfate proteagly {IM346135}-1.51.111.91.72.10.5-0.10-0.9-0.7-1.1-0.7

    Human nucleotide-binding protein mRNA; c {IM376052}1.61.11.71.41.71.3-0.6-0.1-0.7-0.4-0.7-0.3-0.7

    IEX-1=radiation-inducible immediate-earl {IM471556}1.71.71.31.31.7-2.6-0.7-0.7-0.3-0.3-0.71.6-0.7

    ESTs {IM357967}1.71.11.71.21.81.3-0.7-0.1-0.7-0.2-0.8-0.3-0.8

    Human alpha-2-macroglobulin mRNA; 3' end {IM488103}1.611.71.621.2-0.60-0.7-0.6-1-0.2-1

    citrate synthase precursor (EC 4.1.3.7) {IM347719}1.2-1.211.52.22.1-0.20.20-0.5-1.2-1.1-1.2

    Human apolipoprotein C-III (apoC-III) mR {IM364983}1.8-1.1122.22.8-0.80.10-1-1.2-1.8-1.2

    ESTs {IM415326}-1.1-2.1-1.91.52.31.40.11.10.9-0.5-1.3-0.4-1.3

    Human aldehyde dehydrogenase I (ALDH-1) {IM429771}2.1-1.3-1.23.32.32.1-1.10.30.2-2.3-1.3-1.1-1.3

    EST {IM71410}3.2-112.92.42.9-2.200-1.9-1.4-1.9-1.4

    Human tryptophan oxygenase (TDO) mRNA; c {IM327488}1.711.21.52.62.1-0.70-0.2-0.5-1.6-1.1-1.6

    ESTs {IM269320}3.81.31.72.62.8-1.1-2.8-0.3-0.7-1.6-1.80.1-1.8

    Human ApoH mRNA for apolipoprotein H (be {IM234212}7.1-1.5-1.133.11-6.10.50.1-2-2.10-2.1

    beta 2-glycoprotein I [Human; HepG2 hepa {IM358822}6.11.1-1.13.13.21.4-5.1-0.10.1-2.1-2.2-0.4-2.2

    Human glucose-6-phosphatase mRNA; comple {IM124592}21.31.51.43.22.8-1-0.3-0.5-2.4-2.2-1.8-2.2

    Human phenylalanine hydroxylase (PAH) mu {IM243196}4.1-1.113.43.42.7-3.10.10-2.4-2.4-1.7-2.4

    Sheet1

    50.2-0.53.72.44.93.8008.2-0.36.4-0.8-7.37.54.3-21.80.40.90.20.40.4-0.44.2-0.3-4.3-2.10.41.50.2-4.11.8-0.1-4.20-4.34.2-0.60.93.1-2.3-7.8-0.70.1-4.1-7.45.5-0.1-6.20.7-4.2-0.20.5-0.6-0.7-0.7-0.6-0.2-0.80.1-1.1-2.2-0.7-2.8-6.1-5.1-1-3.1TSATSA

    10-0.60.10-0.4100.20.100.10-0.3-0.2-0.10.1-0.31.10.80-0.10.6000.90-0.4-0.31.20.700.9-0.1-0.40.7-0.7-0.21.2-0.2-0.1-0.1-0.6-0.2-0.3-0.1-0.10.20.1-0.6-0.10.10.2-0.1-0.1-0.7-0.100.20.11.10.300-0.30.5-0.1-0.30.1CompetitionCompetition

    40.2-0.100.10.3-0.210.40.20.10-0.9-0.7-0.10.1-0.71.11.5-0.70.10.8-0.50.20.8-0.1-0.5-0.71.50.9-0.30.9-0.301-0.3-0.720.7-1.1-0.7-0.5-0.9-0.9-0.3-0.2-0.1-0.2-0.6-0.7-0.10.10-0.7-0.3-0.7-0.7000.90.20-0