Metabolisme Neurotransmittfer

7/26/2019 Metabolisme Neurotransmittfer

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Metabolisme

neurotransmitter


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Problem anda pada blok ini

Pengaruh neurotransmitter pada jiwa

Obat yang dapat untuk therapi


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Jiwa

Apa yang membentuknya

Pikiran

Tingkah laku Kepribadian

dll


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Sel

Jumlah sel dalam tubuh 500maam !ungsinya berbeda"beda

#im$ositimmunitas tubuh

%ritrosit &b mengikat O' Sel Jiwa atau sub organ

Semua sel energi ( )O'(&'O

%n*im dibuat oleh masing"masing sel

Produk masing"masing


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Membrane

+on,a

+on K

,a" K"ATPase


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,eurotransmitter

-00 maam neurotrans mitter

.ntuk psyhiatri / dopamin danserotonin

Therapi / berhubungan denganneurotransmitter ini


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e1nisi neurotransmitter

Defnition: A neurotransmitter is a hemialmessenger that arries2 boosts and modulatessignals between neuronsand other ells in thebody3

+n most ases2 a neurotransmitter is released $romthe a4on terminal a$ter an ation potentialhasreahed the synapse3

The neurotransmitter then rosses the synapti gap

to reah the reeptor site o$ the other ell orneuron3 Then2 in a proess known as reuptake2 theneurotransmitter attahes to the reeptor site andis reabsorbed by the neuron3
http://psychology.about.com/od/biopsychology/f/neuron01.htmhttp://psychology.about.com/od/aindex/g/actionpot.htmhttp://psychology.about.com/od/aindex/g/actionpot.htmhttp://psychology.about.com/od/biopsychology/f/neuron01.htm


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Sintesis neurotransmitter

eberapa dibentuk dari asam amino


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opamin produksi dansekresi


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,eurotransmitter di selTarget

i$asilitasi 6 protein

Serotonin atau dopamin dikatabolisme


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Sekresi

Serotonin transporter 7pengangkutserotonin8 berikatan dengan ,a( $ollowed by serotonin2 dan )l"3

Sekresi 7releasing8 serotonin3

K( 2 and the transporter 9ips bakout2 ready to reei:e anotherserotonin moleule


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Serotonin is synthesi*ed

amino aid #"tryptophan /Tryptophan hydro4ylase 7TP&8

Amino aid dearbo4ylase

The reation in this pathway that is mediatedby tryptophan hydro4ylase is the rate limitingstep2 meaning that i$ this en*yme is bloked2the synthesis o$ serotonin would be stopped3

Tryptophan hydro4ylase e4ists in two $orms "TP&- and TP&'3 ;hile TP&- is $ound in se:eraltissues2TP&'is spei1ally $ound in ner:es o$the brain3
http://www.news-medical.net/health/The-Human-Brain.aspxhttp://www.news-medical.net/health/The-Human-Brain.aspx


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serotonin transporter

The reyling o$ serotoninisontrolled by the serotonintransporter3

serotonin pathway dari midbrain keorte4 omponen penting mengatur

a


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Penyebab epressi

Penelitian = multiple abnormalitiesdalam serotonergi pathways -8 low onentrations

'8 low density o$ brain and plateletserotonin transporters

>8 a high density o$ brainand platelet

serotonin binding sites= and ?8 a low onentration o$ tryptophan

whih is used in serotonin synthesis3

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Metabolisme Neurotransmittfer