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Metabolisme Asam Nukleat Slide 2 Slide 3 Slide 4 Sintesis Nukleotida Purin Slide 5 Slide 6 Slide 7 Slide 8 Pengendalian Biosintesis Purin Slide 9 Salvage dari Purin Pada mamalia: Adenin fosfo ribosiltransferase (APRT) Adenin + PRPP AMP + PPi Hipoksantin-guanin fosforibosiltransferase (HGPRT) Hipoksantin +PRPP IMP + Ppi Guanin + PRPP GMP + Ppi Lesh-Nyhan Syndrome: HPRT (-) Neurologycal abnorm: PRPP mengaktifkan Amidofosforibosil transferase (thp 2 synt IMP) Nukleotida purin asam urat Slide 10 SINTESIS NUKLEOTIDA PIRIMIDIN Slide 11 Slide 12 Slide 13 Toxoplasmosis Toxoplasma gondii Komplikasi: blindness, neurological dysfunction, & death in immunocompromised individuals Synthesis uracil de novo Inhibitor to carbamoyl phosphate synthetase II Slide 14 Slide 15 Slide 16 Slide 17 DEGRADASI NUKLEOTIDA Slide 18 Jalur Utama Katabolisme Purin Slide 19 Slide 20 Slide 21 Slide 22 Siklus nukleotida purin Slide 23 Slide 24 Degradasi asam urat di berbagai organisme Slide 25 Slide 26 Slide 27 Slide 28 Slide 29 Slide 30 DEGRADASI PIRIMIDIN Slide 31 Slide 32 Slide 33