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Poruke predavanja: (1) Poznati su najvažniji mehanizmi koji kontroliraju starenje kod sisavaca, dakle i kod čovjeka. (2) Starenje je plastičan proces na koji se može utjecati. (3) Razvoj metoda usporavanja starenja će imati veliki utjecaj na našu civilizaciju.Čovjek je zaokupljen starenjem otkad je postao svjestan tijeka vremena i ograničenosti trajanja tijela. Unatoč golemom interesu i stalnim pokušajima da se utječe na starenje, ono je ostalo nedokučiv misterij - sve do nedavno! Znanstvena otkrića u proteklih nekoliko godina su uvelike razjasnila najvažnije mehanizme starenja od molekularne razine u stanicama do procesa starenja organizma. Usporedo sa spoznajama o mehanizmima starenja rastu i naša saznanja o tome kako se boriti protiv takvih procesa. Svjedoci smo ubrzanog razvoja metoda koje nam omogućavaju da aktivno moduliramo svoje starenje i otvaraju perspektive da se značajno produži ljudski vijek uz produženje zdravlja i vitalnosti.
MEHANIZMI STARENJA I DUGOVJENOSTIProf. dr. sc.
Ivica Rubelj
Laboratorij za molekularnu i staninu biologiju Zavod za molekularnu biologiju, IRB
Skeptici 2013
to je starenje?Starenje je proces sveobuhvatnog, ireverzibilnog i progresivnog tjelesnog propadanja koje se dogaa tijekom vremena.Genes, Aging, and Immortality. Charlotte A. Spencer
Starenje
Eduard Veith - Fountain of Youth
Alchemist searching for the Philosopher's Stone Joseph Wright of Derby
Na dugovjenost se moe utjecati !
Porast broja stogodinjaka u SAD
Jeanne Louise Calment: 21 February 1875 4 August 1997
Starenje se odvija na staninoj razini !
Starenje kontroliraju telomere!
Stanino starenjeL. Hayflick
HL
In vitro
mladi fibroblasti
stari fibroblasti
In vivo35 god.
75 god.
Accumulation of senescent cells in tissues
TELOMERE ?
Telomere
?
?
Telomere stanino starenje ?
Teorija marginotomije
mlade
stare
Telomeraza
Telomeraza
C. Greider
spolne stanice matine stanice tumorske stanice jednostaninici
Telomeraza u normalnim fibroblastima
J. Shay HL
W. Wright
HL
Ekspresija telomeraze na razini organizma
Mice overexpressing telomerase (TERT) age more slowly than normal mice. (Blasco laboratory)
Maria A. Blasco
Tert delays ageing. Survival curves and % mice living for more than three years. Neuromuscular coordination as % of mice passing the tightrope test.Tomas-Loba et al. Cell 135, 609622, November 14, 2008
Or Not.
Reeksprimiranje telomereze na razini organizmaRonald A. DePinho
TWO MICE INVOLVED IN AN EXPERIMENT ON AGE-RELATED DEGENERATION. MICE WHOSE TELOMERASE GENE WAS ACTIVATED SHOWED NOTABLE IMPROVEMENTS
Telomere kao indikatori dugovjenosti, bolesti, stresa...
Zato mjeriti telomere?
Adapted from: Tsuji, A., A. Ishiko, et al. (2002). "Estimating age of humans based on telomere shortening." Forensic Sci Int 126(3): 197-9.
Predikcija dugovjenosti?
Association of telomere length in blood DNA after age 60 with subsequent survival. Data are plotted as fitted and smoothed survival curves, according to the group prognosis method. Longer identifies individuals from the top half of the telomere length distribution and shorter those from the bottom half of the distribution. Years since draw means the interval ending with that year (eg, 71 people at risk at end of year 1 for longer group, both sexes).
The relationship between telomere length and survival in humans (after Bakaysa et al. 2007). Those with the longest telomere lengths have the highest survival prospects.
Dulje telomere bolje zdravlje
Telomere length (adjusted for age, gender, and group) according to the absence (gray bars) or presence (white bars) of various age-related diseases in the study subjects. Number of individuals analyzed in each group: hypertension (n = 125), without hypertension (n = 142), with the metabolic syndrome (n = 59), without the metabolic syndrome (n = 286), diabetes (n = 34), without diabetes (n = 276). The MMSE (Mini-Mental State Examination) was performed in centenarians only: MMSE score 25 (gray bars, n = 46) or >25 (white bars, n = 32). *P < 0.05.
ene ive dueTelomere Length in the Newborn
STRES
!Telomere length and telomerase activity levels in extreme high- and low-stress groups. (A) Average telomere length and SE are shown. The highstress group had shorter telomeres even after controlling for age. (B) Average telomerase activity and SE are shown. The high-stress group had lower telomerase activity even after controlling for age.
Moe li se utjecati na nae telomere i starenje?
Longer lives: In tests, the anti-ageing pill increased the life expectancy of animals by 38 per cent
Starenje i prehrana
Resveratrol
Zdraviji metabolizam sporiji gubitak telomera
(Reprinted) JAMA, January 20, 2010Vol 303, No. 3
ANALITIKA TELOMERALaboratorij za molekularnu i staninu biologiju, IRB
Elizabeth Blackburn
Odluite ivjeti due i zdravije!
Anti-aging food
Sports & recreation
ZAHVALJUJEM NA POZORNOSTI