Lifecell Cord Blood Stemcell Banking

8/3/2019 Lifecell Cord Blood Stemcell Banking

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Umbilical Cord Stem Cell Banking

UNDERSTANDING YOUR CHOI


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Cellsmallest functional unit i

Stem Cells are MASTER CEL

Unspecialized cells >> can spe

different cell types.

Make up the babys heart, lung

liver & other organs.

Ability to self-multiply.

Bodys natural repair system


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Residual blood in the babys umbilical cord after birth is cord blood

Its a high concentration of special type of cells called stem cells
http://collection%20method%20avseq02.dat/


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Importance of Umbilical Cord Blood


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Stemcell Cryo-Bag


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Umbilical Cord Blood Uses

Blood cancer

Thalassemia

Sickle Cell Disease

Inherited disorders Stem Cell disorders

Platelet disorders

Immune disorders

OVER 75 BLOOD DISORDERS

T-Cell Lymphoma
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Importance of Cord Tissue

Collection T

Removal of Blo

Culture of MSCs
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THERAPEUTIC POTENTIAL OF MESENCHYMAL STEM CELLS MSCs(CORD TISSUE)

Over 50 clinical trials have been initiated worldwide using MSCs to evaluate their s

efficacy for treatment of diseases such as

Graft vs. Host Disease Phase III

Crohns Disease Phase III

Juvenile Diabetes Phase II

Congestive Heart Failure Phase II

COPD Phase II

Articular Cartilage Defects Phase II

Acute Myocardial Infarction Phase II

Multiple Sclerosis Phase I / II
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History

First unrecorded cord blood transplant in New Je

Leukemia1972 First recorded transplant in France

Fenconi's Anemia1988

Worlds first Cord Blood Stem Cell Bank set-up

In Florida, USACRYO CELL INTERNATION1992 In 20 years, applications increased from 1 to 75 life-threatening diseases.

Over 15,000 successful transplants.

97 Cord Blood Banks in USA.

4 US states where CBB is mandatory.
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New England Journal of Medic

Advancements in Cord Blood Stem Cells

1988 2006

Diseases treatable with Cord Blood 1

Number of cord blood transplants 1 6,0

Number of families who banked cord blood - 400,0

Odds of being diagnosed with a disease that is

treatable with cord blood stem cells, by age 50

1 in 300,000 1 in 1
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Th Vi i f S ll Th i f N l i l D
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The Vision for Stemcell Therapies for Neurological D

Brain and spinal cord in

Stroke.

Neurodegenerative

Parkinsons Dise

Huntingtons Dis

Alzheimers Dise

Multiple Sclero

Lou Gerhigs Diseas
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Lifecell Transplant Matrix

S.No. Date of Release Cord Blood used for

Autologous or Alogenic

Purpose of Transplant Name of the Transplant Physician

1 10.10.2005 Related Allogeneic Acute Myeloid Leukemia DR. RAVATHI RAJ, D.C.H.,M.R.C.P.,(Paediatrics),UK,M.R.C., Path(Hem

Hematology , Bone Marrow Transplantation.

2 28.09.2006 Related Allogeneic Thalasemia Major Professor Dr. Vinai Suwatte M.D.,Ph..D,. Siriraj Hospital Medical Scho

3 19.10.2007 Related Allogeneic Thalasemia Major DR. RAVATHI RAJ, D.C.H.,M.R.C.P.,(Paediatrics),UK,M.R.C., Path(Hem

Hematology , Bone Marrow Transplantation

4 22.05.2007 Related Allogeneic Thalasemia Major DR.PATRICK TAN , Medical Director and Senior Consultant Hematio

Transplant Centre, Hospital Tower B Level 7, Mount Elizabeth Hospi

5 17.04.2007 Related Allogeneic Thalasemia Major Dr. DINESH BHURANI , M.D.,D.M. (Clinical Hematology ) FRCPA (Aus

6 29.08.2008 Related Allogeneic Chronic Myeloid Leukemia DR. RANJAN KUMAR MOHAPATRA,M.B.B.S.,M.D.,(MED),D.M.( ONCOL

Oncologist, Consultant Bone Marrow Tansplant Programme ( Regn .N

7 17.12.2009 Related Allogeneic Thalasemia Major DR. RAVATHI RAJ, D.C.H.,M.R.C.P.,(Paediatrics),UK,M.R.C., Path(Hem


8 29.09.2009 Related Allogeneic Thalasemia Major DR. RAVATHI RAJ, D.C.H.,M.R.C.P. (Paediatrics), UK, M.R.C., Path(Hem


9 16.03.2009 Related Allogeneic Thalassemia Major DR. RAVATHI RAJ, D.C.H.,M.R.C.P.,(Paediatrics), UK, M.R.C. Path(Hem


10 24.01.2009 Related Allogeneic Acute Lyphoblastic

Leukemia

Joannne Kurtzberg,M.D. Professor of Pediatrics & Pathology Director

Transplant Progran Director, Carolinas Cord Blood Bank at Duke (w
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S.No. Date of Release Cord Blood used for

Autologous or Alogenic

Purpose of Transplant Name of the Transplant Physician

11 08.11.2010 Related Allogeneic Thalasemia Major DR. RAVATHI RAJ, D.C.H.,M.R.C.P.,(Paediatrics),Lond,M.R.C., Path(Hemato




13 19.06.2010 Related Allogeneic Thalassemia Major DR. DHARMA R CHOUDHARY DM Clinical Hematology (AIIMS) Hematolog

Memorial Hospital Pusa Road New Delhi-110005

14 18.03.2010 Related Allogeneic Thalassemia Major DR. RAVATHI RAJ, D.C.H.,M.R.C.P.,(Paediatrics),UK,M.R.C., Path(Hematolo




16 12.08.2011 Related Allogeneic Thalasemia Major DR. Dharma R Choudhary,

DM Clinical Hematology (AIIMS) Hematology, Oncologist & BMT B L Kapu

Delhi-110005.

17 16.08.2011 Related Allogeneic Thalasemia Major DR. Satya P Yadav, MBBS DCH DNB

Cosultant Pediatric Hematology & Oncology-Dept of Pediatrics,

Institute of Child Health, Sir Ganga Ram Hospital,

Rajinder Nagar, New Delhi-110 060
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Real case of Cord Blood Transplant?

Has a bit of his brother insi

Has conquered Thalassemia

March 2009A vital day

Apollo Hospital , Chennai
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Lifecell International Private Limited


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Lifecell International Private Limited

About the Promoter

Lifecell has been promoted by the Promoter of Shasun Chemicals

Limited(www.shasun.com), a Chennai based Rs.500 crore pharma

& biotech company. Shasun is a widely respected company which

has been in business since 1976, and is also listed on the NSE &

BSE.

Shasun has three facilities in India and two in UK.

Shasun is one of the largest producers of Ibuprofen worldwide.

The company offers derivatives of Ibuprofen like Ibuprofen

Sodium, Ibuprofen Lysinate and S+Ibuprofen. It is also one of the

major producers of Ranitidine and Nizatidine in the world. Itsproducts are exported to countries across North America, Europe,

Asia and Latin America.


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ABOUT LIFECELL

Established in 2004, LifeCell is today Indias largestcell bank with presence in over 65 cities and with m

than 35,000+ clients

Its quality systems have been accredited by organiz

such as DGCI,ISO,AABB,CAP,USFDA,DSIR,Etc.

Dedicated stem cell company offering complete por

of services including R&D, Multi-Service Banking,

Therapy, and Clinical Research

Technology partnerships with industry leaders suc

Cryo-Cell International, and Harvest Therapeutics
http://avseq01-lab.dat/


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AABB Accreditation

The AABB (American Association of Bloo

Program strives to improve the quality anprocessing, testing, distributing and adm

products. It assesses the quality and oper

the cord blood banking facility and ensur

Standards, Code of Federal Regulations a

documents.This independent assessmen

helps the facility to prepare for other insp

valuable tool to improve both compliance

Accreditation is usually granted for colle

distribution and administration of bloodhematopoietic progenitor cell activities; c

perioperative activities; parentage testin

immunohematology reference laboratori


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The Research and Developm

LifeCell has been recognize

Department of Scientific an

Research (DSIR), Govt. of In

certification endorses our a

research protocols and proc

formally recognized by the

this certification serves as apromote further research in

to collaborate with other na

institutions of excellence.


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Why Laboratory Accreditation ?

The concept of Laboratory Accreditation was developed to provide a means for third-party

certification of the competence of laboratories to perform specific type(s) of testing and

calibration.

Laboratory Accreditation provides formal recognition of competent laboratories, thus

providing a ready means for customers to f ind reliable testing and calibration services in order

to meet their demands. Laboratory Accreditation enhances customer confidence in accepting

testing / calibration reports issued by accredited laboratories.

The Globalization of Indian economy and the liberalization policies initiated by the

Government in reducing trade barriers and providing greater thrust to exports makes it

imperative for Accredited Laboratories to be at international level of competence.

Benefits of Accreditation

Formal recognition of competence of a laboratory by an Accreditation body in accordance

with international criteria has many advantages:

Potential increase in business due to enhanced customer confidence and satisfaction.

Savings in terms of time and money due to reduction or elimination of the need for re-testing of

products.

Better control of laboratory operations and feedback to laboratories as to whether they have

sound Quality Assurance System and are technically competent.

Increase of confidence in Testing / Calibration data and personnel performing work.

Customers can search and identify the laboratories accredited by NABL for their specific

requirements from the Directory of Accredited Laboratories.

Users of accredited laboratories will enjoy greater access for their products, in both domestic

and international markets, when tested by accredited laboratories.


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It was a team of 7 Doctors from College of American Pathologists (CAP) to test

and certify our quality practices. The accreditation certified is called CAP

Accreditation in terms of the authority on certification they provide on thePathological Tests ,like Haematology, Microbiology, Serology and Flow

Cytometry which ensures reliability of results and superior customer care.

The distinguished team had an interaction with the Heads of the department as

well as the Technologists while scrutinising the Standard Operating

Procedures, posters, safety and most importantly the competencies of the Staff

as well as their continuous training.Now, the great news is that, the CAP

Auditors were impressed with our quality of service and practices.


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US FDA Standards

The United States Food & Drug Administration (US FDA) is the largest government

regulatory body responsible for the protection of public health. During the earlyyears of cord blood banking, the only regulation that the FDA imposed was

mandatory screening for certain diseases such as HIV. But since 2005, the US FDA

has framed a full body of regulations outlining the procedures and methods that

banks and laboratories must follow. These regulations cover the appropriate

collection, processing, packaging, labeling and distribution of cord blood stem cell

In the United States, it is therefore mandatory for all cord blood banks to adhere to

the FDA's regulations, which ensure the safe handling and storage of cord bloodstem cells. And when a cord blood bank also has AABB Accreditation, it is further

evidence of the bank's commitment to quality.


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Features of Lifecell International Pvt.Ltd.

First Stem Cell Company who started the concept in India with Technology Partner Cryo-cell Inc.

First Stem Cell Company to get ISO 9001-2000 certificate

First Stem Cell Company to get the prestigious accreditation from AABB

First Stem Cell company to get the DSIR recognition of In-House R&D Unit

First Stem Cell Company to own its own Transplant & Clinical Trials Cenmte TRICell

First Stem Cell Company to get the prestigious registration USFDA

First Stem Cell Company to get the prestigious ACCREDITATION OF NABL

CGMP & CGLP Fitted with a central monitoring system which monitors Temperature, Humidity and Pressure.

Class 100 Clean Room with 0.3 Micron HEPA Filters

Confirms to USFDA Standards

Unique LIMS to track samples after storage

UN 3373 Certification for Collection Kit Box

3 Unique IDs for every sample stored ( Customer ID, Lab ID& Sample ID ) Total Sample preserved 40,000+

We already provided 17 samples to our clients for the Transplant

5 Lac Insurance for Stemcell Transplant for the particular child anywhere in India

10 Lac will be provided in the event if the Stemcell not ingraft in the Body. Or Disaster Relief Pragramme

Worldwide free retrieval

NBS for 101+ Genetic Disorders

P f St C ll B ki


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Process of Stem Cell Banking

Registration KitBox DeliveredCall 24*7 to Lifecell Fo

Collection

Paramedic

th

Sample Despatch to Lab Through

Bluedart/JetAirways

Processing of Sample Report Despatched after 45day


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Documents

Lifecell Cord Blood Stemcell Banking