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Liam Brown PROFILE I am a postdoctoral fellow in the Mathematical Institute and Kennedy Institute at the University of Oxford, in collaboration with Celgene. I study the trafficking of bioengineered T-cells through the body and the factors that limit their efficacy in humans and mice. My research interests include immune and tumour biology especially and mathematical biology more generally, aiming towards an integrated clinical, experimental and theoretical approach. EDUCATION 2014–2019 Doctoral Training Centre (DTC) and DPhil (PhD), University of Oxford. Associated with the Systems Approaches to Biomedical Science DTC, which provided interdisciplinary training for one year before leading to a DPhil in the mathematics department from 2015. Thesis submitted December 2018, viva completed 2019. 2010–2014 MSci Physics, Imperial College London, First class honours (78%). MSci project was a cellular automaton model of Atrial Fibrillation. RESEARCH 2016– T-cell trafficking, Mathematical Institute, University of Oxford. Supervisors: Prof. Eamonn Gaffney (Oxford), Prof. Mark Coles (Oxford) and Dr. Jonathan Wagg (Roche). Produced a model of T-cell trafficking in the bloodstream, to estimate upper limits of the delivery rate of T-cells to tumours in different organs and different species. Manuscript in preparation. 2015– T-cell activation, Mathematical Institute, University of Oxford. Supervisors: EG,MC,JW. Produced a model of T-cell activation in the lymph node following short-peptide vaccination, to investigate how activation depends on both patient and peptide properties. Published. 2016– Virtual clinical trials, Mathematical Institute, University of Oxford. Supervisors: EG,MC,JW. Produced a virtual clinical trial of IMA-901 using the above lymph node model, yielding simulated results consistent with IMA-901. Manuscript in preparation. 06–08/2017 Delta-Notch patterning, Kobayashi Lab, Hiroshima University. Supervisor: Prof Seirin Lee. Produced a cellular automaton to describe the formation of patterns in developing tissue due to Delta and Notch. 11/2016 Mechanisms of tumour resistance, Moffitt Cancer Center, IMO Workshop 2016. Created a combined cellular automaton and image analysis program as a team. Investigated links between lung cancer CT scan features and clinical outcome or particular resistance mechanisms. bioRxiv manuscript published. PUBLICATIONS 09/2019 Liam V Brown et al. BioRxiv 759167. 09/2018 Liam V Brown et al. Clinical and Experimental Immunology 193:284-292, 2018. 03/2018 Liam V Brown et al. Journal of the Royal Society Interface 15(140), 2018. 09/2017 Daryoush Saeed-Vafa et al. bioRxiv 190561. PRESENTATIONS 09/2019 Comparative Anatomical Limits of CAR T-Cell Delivery to Tumours in Mice and Men. Trinity College Meeting "From the Lab to the Clinic" and Philip Maini’s 60 th birthday conference. 05/2019 Not of mice, but men: how does immunotherapeutic success depend on species?. BSI Mathematical Modelling Affinity Group Meeting. No prizes were given at this conference. 07/2018 Simulation of a Short Peptide Vaccination in a Virtual Clinical Trial. ECMTB 2018, Lisbon. No prizes were given for talks at this conference. 06/2018 In silico clinical trials to identify mechanisms limiting short-peptide vaccination efficacy. Invited speaker, Tübingen University. B [email protected] ˝ people.maths.ox.ac.uk/brown/

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Page 1: Liam Brownpeople.maths.ox.ac.uk/brown/CV.pdf · Liam Brown PROFILE IamapostdoctoralfellowintheMathematicalInstituteandKennedyInstituteattheUniversityofOxford,in …

Liam BrownPROFILE

I am a postdoctoral fellow in the Mathematical Institute and Kennedy Institute at the University of Oxford, incollaboration with Celgene. I study the trafficking of bioengineered T-cells through the body and the factorsthat limit their efficacy in humans and mice. My research interests include immune and tumour biologyespecially and mathematical biology more generally, aiming towards an integrated clinical, experimental andtheoretical approach.

EDUCATION2014–2019 Doctoral Training Centre (DTC) and DPhil (PhD), University of Oxford.

Associated with the Systems Approaches to Biomedical Science DTC, which provided interdisciplinarytraining for one year before leading to a DPhil in the mathematics department from 2015. Thesissubmitted December 2018, viva completed 2019.

2010–2014 MSci Physics, Imperial College London, First class honours (78%).MSci project was a cellular automaton model of Atrial Fibrillation.

RESEARCH2016– T-cell trafficking, Mathematical Institute, University of Oxford. Supervisors: Prof. Eamonn

Gaffney (Oxford), Prof. Mark Coles (Oxford) and Dr. Jonathan Wagg (Roche).Produced a model of T-cell trafficking in the bloodstream, to estimate upper limits of the deliveryrate of T-cells to tumours in different organs and different species. Manuscript in preparation.

2015– T-cell activation, Mathematical Institute, University of Oxford. Supervisors: EG,MC,JW.Produced a model of T-cell activation in the lymph node following short-peptide vaccination, toinvestigate how activation depends on both patient and peptide properties. Published.

2016– Virtual clinical trials, Mathematical Institute, University of Oxford. Supervisors: EG,MC,JW.Produced a virtual clinical trial of IMA-901 using the above lymph node model, yielding simulatedresults consistent with IMA-901. Manuscript in preparation.

06–08/2017 Delta-Notch patterning, Kobayashi Lab, Hiroshima University. Supervisor: Prof Seirin Lee.Produced a cellular automaton to describe the formation of patterns in developing tissue due to Deltaand Notch.

11/2016 Mechanisms of tumour resistance, Moffitt Cancer Center, IMO Workshop 2016.Created a combined cellular automaton and image analysis program as a team. Investigated linksbetween lung cancer CT scan features and clinical outcome or particular resistance mechanisms.bioRxiv manuscript published.

PUBLICATIONS09/2019 Liam V Brown et al. BioRxiv 759167.09/2018 Liam V Brown et al. Clinical and Experimental Immunology 193:284-292, 2018.03/2018 Liam V Brown et al. Journal of the Royal Society Interface 15(140), 2018.09/2017 Daryoush Saeed-Vafa et al. bioRxiv 190561.

PRESENTATIONS09/2019 Comparative Anatomical Limits of CAR T-Cell Delivery to Tumours in Mice and Men.

Trinity College Meeting "From the Lab to the Clinic" and Philip Maini’s 60th birthday conference.05/2019 Not of mice, but men: how does immunotherapeutic success depend on species?.

BSI Mathematical Modelling Affinity Group Meeting. No prizes were given at this conference.07/2018 Simulation of a Short Peptide Vaccination in a Virtual Clinical Trial.

ECMTB 2018, Lisbon. No prizes were given for talks at this conference.06/2018 In silico clinical trials to identify mechanisms limiting short-peptide vaccination efficacy.

Invited speaker, Tübingen University.

B [email protected] • Í people.maths.ox.ac.uk/brown/

Page 2: Liam Brownpeople.maths.ox.ac.uk/brown/CV.pdf · Liam Brown PROFILE IamapostdoctoralfellowintheMathematicalInstituteandKennedyInstituteattheUniversityofOxford,in …

06/2018 Quantifying Physiological Limits for Rates of Immune Cell Entry into Different Organs AcrossSpecies.Cancer Research UK Oxford Centre 2018 Symposium. Received a poster prize.

05/2018 Simulation of a Short Peptide Vaccination in a Virtual Clinical Trial.CIMT 2018, Mainz.

04/2018 Simulation of a Short Peptide Vaccination in a Virtual Clinical Trial (talk and poster).Oxford Immunology Symposium. Received a poster prize.

04/2017 Quantifying Physiological Limits for Rates of Immune Cell Entry into Different Organs AcrossSpecies.BMS/UKCAS Conference, Birmingham. Received a travel grant and a poster prize.

02/2017 Fighting Cancer with Mathematics.MPLS Divisional Talk, Lady Margaret Hall. Sole speaker for the event.

10/2016 Critical Determinants of T-Cell Activation Success.IMO 2016 Workshop, Moffitt Cancer Center.

06/2016 Optimising Delivery of Short-Peptide Cancer Vaccines.Invited talk, Hiroshima University.

02/2016 Quantifying Probability of T-Cell Activation.Research Fair, Lady Margaret Hall.

10/2015 Quantifying Probability of T-cell Activation: Sensitivity to Number of Migrating DendriticCells & Cognate Antigen Expression Levels.Roche pRED Clinical Symposium, New York.

AWARDS AND SCHOLARSHIPS09/2019 Linacre Biomedical Junior Research Fellowship, one year, renewable, non-stipendiary JRF.01/2019 Oxford-Celgene Fellowship, three years funding for postdoctoral research and expenses.

2014–2018 Clarendon Scholarship, awarded to top 2% of graduates, to fund DPhil fees and living expenses.2017–2018 Various poster prizes and travel grants, see above.

06–08/2017 Visiting researcher, funding from Hiroshima Uni. to cover travel, living and research expenses.06–08/2013 Undergraduate Research Opportunities Programme.

RESEARCH ENGAGEMENT AND OUTREACH05/2019 Oxford Mathematics Festival, Oxford Town and Mathematical Institute, Oxford.

Helped visitors experience the Dimensions VR app (see below) at the mathematics festival, and playedthe part of the Detective Chief Inspector in the Mathematical Institute’s escape room.

03/2019 STEM for Britain, Houses of Parliament, London.Selected to present a poster of my work to staff, visitors, Members of Parliament and other scientistsat the Houses of Parliament.

2019 Dimensions: The Mathematics of Symmetry and Space, Ashmolean Museum, Oxford.As part of a team of four, programmed a virtual reality (VR) game to convey the concept of dimensions(particularly 4 dimensions) in the exhibition, and helped to train staff and visitors in its use.

OTHER EXPERIENCE09/2017–03/2018

Intern, Disease Modelling Group, Clinical Pharmacology, Hoffmann-La Roche, Basel.Conducted further research for my DPhil, collaborated on work with other modellers, attended talksand courses, gave talks on my research and offered my expertise on various problems and projects.Reported to Jonathan Wagg and Jean-Eric Charoin.

2014–2018 Teaching, King’s College School; Sudbury Upper School; Maths Department, University ofOxford; Sudbury Resource Centre.I have experience demonstrating, giving short lectures and marking for school pupils and universitystudents. I have taught basic IT skills to adults for several weeks as a volunteer.

2014–2015 IT & Communications Officer, Clarendon Scholar’s Council, University of Oxford.Responsible for communication and software for the Clarendon Scholarship. Redesigned the emailbulletin system to send HTML-formatted information automatically. Organised and ran various events.

B [email protected] • Í people.maths.ox.ac.uk/brown/

Page 3: Liam Brownpeople.maths.ox.ac.uk/brown/CV.pdf · Liam Brown PROFILE IamapostdoctoralfellowintheMathematicalInstituteandKennedyInstituteattheUniversityofOxford,in …

2011–2013 Treasurer, Gaming Society, Imperial College London.Responsible for society finances and the running of weekly sessions or special events. Led a reorgani-sation of the society to reflect modern changes in the hobby over the decades.

OTHER INTERESTSLanguage

studyStudied Japanese since 2013 and German since 2017. Received a distinction(+) for Oxford Japaneseclasses for three consecutive years, and the best Japanese presentation award in 2016. Spent Summer2017 in a Japanese research group. My Japanese and German levels are approximately N3-N2 and B1.

Rowing Rowed recreationally since 2015, competing in my college’s first boat in 2016–2017.

B [email protected] • Í people.maths.ox.ac.uk/brown/