Let's Go Crazy

Embed Size (px)

Text of Let's Go Crazy

PowerPoint Presentation

Medical Provider Meeting 5/3/2016Community-University Health Care Center

In honor of the recent passing of our local artist - Lets Go Crazy: New Diabetes Drugs1

Long-acting insulinsSGLT-2 inhibitorsGLP-1 agonistsThe future

2

Theme here: long longer-acting, longer-lasting3

Insulin degludec - human insulin analogLong-actingHalf-life >24 hours, detectable for 96 hoursSmooth, flat profile over 24 hoursWhen compared to insulin glargineNo difference in glycemic controlLess variabilityLess nighttime hypoglycemia

4

FlexTouch PensU100 and U200 concentrationsWhat you click is what you getConversion from Lantus 1:1Lasts 56 days after opening

W/ U200 can give 160 units at a time

5

U300 more concentrated LantusFlatter, longer profile than U100Duration of 24 hours, detectable for 36 hoursSimilar efficacy to U100 glargineLess hypoglycemia Both overall and nighttimeCost similar to U100 on a unit-per-unit basis

Smaller injection volumePen dials to 806

Conversion from LantusStart with 1:1 conversionDM2 patients typically need 11-15% moreDM1 patients typically need 17.5% moreMay have a temporary increase in FBGInsulin nave patients may take 5 days to achieve full effectUse within 42 days

May need to supplement for first 24 hours80% TTD NPH

7

Identical amino acid sequence to LantusAvailable mid-December 2016Only in pens (KwikPen)

Not a biosimilar approved through the New Drug Application pathwayEli LillyKwikPen dials out

8

Now available in a pen increased safetyActs like regular/NPH mixOnset 30 minutesLasts up to 24 hours2-4 injections per day

What you click is what you get9

10

Blocks reabsorption of glucose in the proximal tubule of the kidney.Lower the threshold at which glucose is excreted