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Leadership Through Innovation TM 1 Nevro Leadership Through Innovation TM Leadership Through Innovation TM LEADERSHIP THROUGH INNOVATION TM Nevro

Leadership Through Innovation TM 1 Nevro Leadership Through Innovation TM LEADERSHIP THROUGH INNOVATION TM Nevro

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Leadership Through Innovation TM 1Nevro

Leadership Through Innovation TM

Leadership Through Innovation TM

LEADERSHIP THROUGH INNOVATION TM

Nevro

Leadership Through Innovation TM 2Nevro

Leadership Through Innovation TM

Nevro: Advancing Spinal Cord Stimulation

Novel Rechargeable Spinal Cord Stimulator

Implantable device placed minimally invasively by Pain Specialists and Spine Surgeons

Unique high-frequency waveform up to 10kHz

Anatomic lead placement without paresthesia mapping

The Senza® System is an investigational device in the U.S.

Leadership Through Innovation TM 3Nevro

Leadership Through Innovation TM

Company Milestones

2006

Founded at Mayo: Initial idea generation roundtable

Founded at Mayo: Initial idea generation roundtable

Validation in additional large animal model: UC Davis

Validation in additional large animal model: UC Davis

Animal work: Stanford University

Animal work: Stanford University

Early external prototype testing

Early external prototype testing

Pilot short term testing in US study

Pilot short term testing in US study

International pivotal clinical

International pivotal clinical

European launchEuropean launch

IDE initiatedIDE initiated

2007 2008 2009 2010 2011 2012

US IP issuedUS IP issued

Leadership Through Innovation TM 4Nevro

Leadership Through Innovation TM

US Senza-RCT Study Underway

Non-inferiority study on safety and efficacy

Senza compared to commercially available SCS

Negotiated with the FDA

Largest randomized SCS study ever conducted

First study to compare SCS device systems

The Senza® System is an investigational device in the U.S.

Leadership Through Innovation TM 5Nevro

Leadership Through Innovation TM

Safety and Effectiveness Endpoints

Primary

Secondary

Tertiary

Non-inferiority comparison: change in back pain VAS and neurological status from baseline

• Assessments such as

• % change in back pain, leg pain, function

• Adverse event rates

• Paresthesia perception

• Includes sleep quality, quality of life, depression level, pain med usage

The Senza® System is an investigational device in the U.S.

Leadership Through Innovation TM 6Nevro

Leadership Through Innovation TM

Pain Gaining Recognition as a Challenge

Leadership Through Innovation TM 7Nevro

Leadership Through Innovation TM

Interventional techniques (i.e. blocks)

Physical therapy &

conservative therapies

Spinesurgery

Oralopioids

Spinal cord stimulation

DrugPumps

SCSExpansion

Opportunity

Opportunity for SCS Community

Leadership Through Innovation TM 8Nevro

Leadership Through Innovation TM

Difficult Funding Environment for Innovation

Leadership Through Innovation TM 9Nevro

Leadership Through Innovation TM

Opportunity for Neuromodulation

Significant opportunity for neuromodulation to improve healthcare

To accomplish this, additional effort needed in:

Clinical Evidence

Patient Experience

Education for HCP and Payers