Katalog kurser på forskarnivå HT12 - KIkiwas.ki.se/kicoursecatalogueHT12.pdf · Katalog kurser på forskarniv

Katalog kurser på forskarnivå

HT12

# Sjukdomslära * Allmänvetenskap Laboratory Animal Science 2012-09-10 -- 2012-09-26 (Engelska)1131 Apoptosis: Theory and Methods 2012-10-08 -- 2012-10-12 (Engelska)1201 Human Cell Culture. Methods and Applications 2012-08-20 -- 2012-08-24 (Engelska)1202 Transcultural Mental Health - screening, intervention and evaluation 2012-10-01 -- 2012-10-05 (Engelska)1257 Developmental and Perinatal Physiology 2012-08-20 -- 2012-08-24 (Engelska)1264 Basic Course in Medical Statistics * 2012-12-03 -- 2012-12-14 (Engelska)1383 Philosophy of science and research ethics * 2012-09-17 -- 2012-09-21 (Engelska)1386 Philosophy of science and research ethics * 2012-11-19 -- 2012-11-23 (Engelska)1386 Medicinsk vetenskapsteori och forskningsetik * 2012-10-29 -- 2012-11-02 (Svenska)1386 Writing science and information literacy * 2012-11-26 -- 2012-12-07 (Engelska)1391 Vetenskapligt skrivande och informationskompetens * 2012-10-15 -- 2012-10-26 (Svenska)1392 Flow cytometry: from theory to application 2012-09-24 -- 2012-09-28 (Engelska)1496 Rörelseapparaten - klinisk utvärdering av funktion och behandling 2012-10-15 -- 2012-10-19 (Svenska)1507 Epidemiology I: Introduction to epidemiology 2012-10-16 -- 2012-10-25 (Engelska)1577 Biostatistics I: Introduction for epidemiologists * 2012-09-19 -- 2012-10-11 (Engelska)1579 Signal transduction in brain diseases 2012-11-26 -- 2012-11-30 (Engelska)1587 From tumor immunology to immune and gene therapy of cancer 2012-11-12 -- 2012-11-16 (Engelska)1594 Molecular Immunology 2012-11-12 -- 2012-11-23 (Engelska)1595 Oxidative stress: Disease, Methods and Concepts 2012-08-27 -- 2012-08-31 (Engelska)1620 Cytokines in inflammation 2012-10-15 -- 2012-10-26 (Engelska)1626 Basic course in Tumor Biology andf Oncology 2012-11-19 -- 2012-11-30 (Engelska)1635 Application of Epidemiological Methods in Aging Research 2012-11-26 -- 2012-11-30 (Engelska)1639 Epidemiology III. Analysis and interpretation of epidemiological data 2012-11-26 -- 2012-12-05 (Engelska)1684 Biostatistics III: Survival analysis for epidemiologists 2012-11-12 -- 2012-11-23 (Engelska)1685 Datainsamling och dataanalys II 2012-09-03 -- 2012-11-23 (Svenska)1711 Study design in clinical research 2012-09-07 -- 2012-10-19 (Engelska)1794 Metoder för kvalitativ innehållsanalys 2012-10-16 -- 2012-12-05 (Svenska)1814 Improving drug use, especially antibiotics 2012-09-10 -- 2012-09-14 (Engelska)1846 Penotyping of genetically engineered mice 2012-11-26 -- 2012-11-30 (Engelska)1974 Embryology I 2012-10-15 -- 2012-10-19 (Engelska)1999 What is life? The future of biology. 2012-09-18 -- 2013-02-28 (Engelska)2001 Introduction to Stata for epidemiologists 2012-09-17 -- 2012-10-31 (Engelska)2041 Pathology # 2012-10-08 -- 2012-10-19 (Engelska)2044 How to write a successful grant application * 2012-10-01 -- 2012-10-23 (Engelska)2095 Inherited cancer syndromes; Genes predisposing to malignant disease 2012-11-05 -- 2012-11-09 (Engelska)2110 Forskningsetik * 2012-11-06 -- 2012-11-27 (Svenska)2132 To communicate science in different contexts * 2012-09-06 -- 2012-10-12 (Engelska)2144 Att kommunicera vetenskap i olika sammanhang * 2012-11-20 -- 2012-12-19 (Svenska)2144 Cardiovascular Epidemiology 2012-11-05 -- 2012-11-09 (Engelska)2154 Malaria 2012-11-26 -- 2012-11-30 (Engelska)2163 Cellular and molecular infection biology 2012-11-19 -- 2012-11-30 (Engelska)2176 Course in endocrinology and metabolism 2012-10-22 -- 2012-10-26 (Engelska)2179 Developmental biology for regenerative medicine 2012-09-03 -- 2012-09-14 (Engelska)2188 Introduction in Medical Education Research 2012-10-03 -- 2012-12-06 (Engelska)2193 Social skills: Presentation techniques, cooperation and relationships * 2012-11-26 -- 2012-12-07 (Engelska)2198 Social kompetens: Presentationsteknik, samarbete och relationsbyggande * 2012-12-03 -- 2012-12-14 (Svenska)2198 Basic Laboratory Safety * 2012-10-22 -- 2012-10-26 (Engelska)2211 Non-coding RNAs, microRNAs in human diseases 2012-10-22 -- 2012-10-26 (Engelska)2275 Live cell imaging 2012-10-29 -- 2012-11-09 (Engelska)2283 Neuroanatomy from development to adulthood 2012-08-31 -- 2012-09-12 (Engelska)2285 Advanced seminars in cancer biology incl. infection-associated cancers 2012-08-28 -- 2012-12-18 (Engelska)2288 Clinical achievements of reproductive medicine 2012-09-03 -- 2012-09-07 (Engelska)2291 Basic immunology 2012-09-18 -- 2012-10-25 (Engelska)2302 Functional Fluorescence Microscopy Imaging (fFMI) in biomedical research 2012-12-03 -- 2012-12-14 (Engelska)2348 Observation och video som forskningsmetod inom vårdområdet 2012-10-24 -- 2012-11-16 (Svenska)2350 Molecular localisation in cells using fluorescence microscopy 2012-11-12 -- 2012-11-23 (Engelska)2356 Mouse models of human cancer 2012-11-19 -- 2012-11-26 (Engelska)2367 Applied Bioinformatics * 2012-11-05 -- 2012-11-16 (Engelska)2414 Methods in molecular biology and their applications in medical research 2012-09-03 -- 2012-09-14 (Engelska)2418 Medical nanosciences 2012-11-13 -- 2012-11-16 (Engelska)2429 Undervisning och lärande i högre utbildning: doktorandkurs i pedagogik * 2012-11-19 -- 2012-12-21 (Svenska)2434 Public health intervention and implementation research 2012-11-05 -- 2012-12-14 (Engelska)2454 SPSS I - datahantering för att beskriva dina data 2012-09-12 -- 2012-09-14 (Svenska)2475

Science education in emergency medicine 2012-10-22 -- 2012-10-26 (Engelska)2506 Cancer cell energy metabolism 2012-11-19 -- 2012-11-23 (Engelska)2515 Basics of Qualitative research 2012-10-15 -- 2012-10-19 (Engelska)2518 Research documentation: theory and real examples * 2012-10-01 -- 2012-10-05 (Engelska)2521 Mass spectrometry-based proteomics: When and How. 2012-10-22 -- 2012-11-02 (Engelska)2522 Omics data analysis: From raw data to biological information 2012-11-19 -- 2012-11-30 (Engelska)2523 Cellular Reprogramming - from basal mechanisms to medical applications 2012-09-19 -- 2012-09-25 (Engelska)2525 Writing Science and Information Literacy * 2012-08-20 -- 2012-10-12 (Engelska)2561 Basic principles in molecular imaging for medical diagnostics through magnetic resonance physics 2012-10-22 -- 2012-11-022568

(Engelska) Introduction to R statistical analysis for biologists 2012-11-26 -- 2012-11-30 (Engelska)2570 Zebrafish cell biology and genetics - practical course 2012-10-10 -- 2012-10-17 (Engelska)2587 Plasticity in the auditory system 2012-10-01 -- 2012-10-05 (Engelska)2596 Competing risks and multi-state models: concepts, methods and software 2012-10-01 -- 2012-10-04 (Engelska)2597 Biologically based exposure assessment for epidemiology 2012-09-17 -- 2012-09-21 (Engelska)2599 Neurogenetics 2012-10-08 -- 2012-10-12 (Engelska)2600 Epigenetics and its applications in clinical research 2012-09-25 -- 2012-10-03 (Engelska)2601 Stem cell engineering and regenerative medicine 2012-10-01 -- 2012-10-05 (Engelska)2603 Multi- and mega variate data analysis theory and practice in omics research 2012-10-08 -- 2012-10-12 (Engelska)2604 Brain development and Neurodevelopmental disorders 2012-10-01 -- 2012-10-05 (Engelska)2605 Advanced topics in genome biology 2012-09-20 -- 2012-11-15 (Engelska)2607 Mechanisms of Gene Regulation in Metabolism 2012-11-12 -- 2012-11-16 (Engelska)2608 Basic Course in Medical Statistics - a distance course * 2012-11-12 -- 2012-11-23 (Engelska)2609 Basic Course in Medical Statistics - a distance course * 2012-10-08 -- 2012-10-19 (Engelska)2609 Early drug discovery in the cancer field 2012-10-29 -- 2012-11-02 (Engelska)2610 Clinical research in practice 2012-11-09 -- 2012-12-14 (Engelska)2612 Pediatric Oncology Research 2012-11-05 -- 2012-11-09 (Engelska)2614 Mesenchymal stem cells and sarcoma. From biology to clinical management. 2012-11-19 -- 2012-11-23 (Engelska)2615 Frontiers in Cogntive Neuroscience 2012-09-10 -- 2012-09-14 (Engelska)2616 Social and life course epidemiology 2012-11-19 -- 2012-11-23 (Engelska)2617 Write your research results and get them published * 2012-10-29 -- 2012-11-09 (Engelska)2618 Skriv och publicera dina forskningsresultat * 2012-11-12 -- 2012-11-23 (Svenska)2618 Laboratory Techniques and Analysis of Results - Orientation course 2012-10-22 -- 2012-11-02 (Engelska)2619 Scientific visualization and presentation in 3D 2012-10-01 -- 2012-10-19 (Engelska)2620 Klinisk forskning och Good Clinical Practice: protokoll, informerat samtycke och ansökan i enlighet med lagar/regler *2621

2012-11-12 -- 2012-11-23 (Svenska) Medfödda immunförsvars receptorer för detektion av aminosyror 2012-10-01 -- 2012-11-07 (Svenska)2623 Brain circuits 2012-09-17 -- 2012-09-21 (Engelska)2624 Research course on individualized drug dosage in clinical practice and in drug development-application of clinical2625

pharmacokinetic/pharmacodynamic concepts 2012-10-29 -- 2012-11-16 (Engelska) Perinatologi 2012-12-05 -- 2012-12-31 (Svenska)2626 Neurodegenerative disorders I - From molecule to treatment 2012-09-24 -- 2012-09-28 (Engelska)2629 Neurodegenerativa sjukdomar II - cellulära och molekylära mekanismer 2012-10-22 -- 2012-10-26 (Svenska)2630 Grundläggande biostatistik * 2012-10-22 -- 2012-10-26 (Svenska)2634

Title : Laboratory Animal Science

1131Kursnummer : 4.5Antal högskolepoäng :

2012-09-10 -- 2012-09-26Datum : EngelskaSpråk :

ForskarnivåNivå : Comparative medicineKursansvarig institution :

Särskild behörighet : After the course, the student will possess the following qualifications 1.Humane use of animals. Know how toKursens lärandemål :

handle laboratory animals in a humane manner. 2.The Swedish law and required permissions. Knows the legal requirements inSweden for conducting animal experiments. Knows where and how to apply for required ethical permission. Capable to translatelegal and ethical requirements into the practical design of new animal experiments. 3.Housing and breeding of laboratory animals.Can discuss laboratory environments vs. animal quality of life and hygienic needs. Handles both wild type and genetically modifiedanimals effectively and safely. Can explain how animal nutrition may impact on research results. 4.Laboratory animal diseases andhealth risks. Knows microbes and parasites that commonly infect laboratory animals. Can explain how these may impact onexperimental results. Can demonstrate how common health risks and preventable adverse events in laboratory animals can beminimised. 5.Practice. Can handle laboratory animals appropriately with respect to species differences. Can identify and applyappropriate methods for experimental treatment, such as administration of analgesia or anaesthesia, surgery including perioperativecare, and euthanasia. 6.Alternative methods, species selection, and power calculations. Can systematically explore and evaluateanimal free research methods. Can appropriately select animal species, where needed for new research activities. Can calculate thestatistical power of a study and minimal sample size to minimise the use of animals. Complies with good laboratory practice (GLP)requirements where needed.

The course contents are in accordance with recommendations from the Federation of European LaboratoryKursens innehåll : Animal Science Associations (FELASA) and with the European legislation. Contents include introduction to laboratory animalscience, design of animal experiments, legislation, laboratory animal genetics, behaviour, stress and homeostasis, allergies andother health hazards, safety in a laboratory environment, gnotobiology, nutrition, animal welfare, environment and experimentalprocedures, transgenic technologies, alternatives to animal use, good laboratory practice, diseases of laboratory animals,preventions of infections, anaesthesia, surgery, euthanasia, ethics, animal protection and animal models in research. Small groupswill go through demonstrations in rabbits and guinea pigs. Laboratory practice includes techniques for handling and restraint,injection, sampling and anaesthesia in rats and mice. Additionally, students will prepare an experimental protocol and analyse ascientific paper. A written examination is included.

Lectures, group assignments and laboratory practice.Arbetsformer : Written exam, practical exam and group assignments Examination :

All practical sessions, all group works and some of the lectures are compulsory. Missed parts can beObligatoriska moment : completed after agreement with Course Director.

30 - 60Antal studenter : Students will be selected based on a motivation letter and complete filled application. Do not forget to give theUrval av studenter :

date of your registration as a doctoral student. Only COMPLETE APPLICATIONS with a motivation letter, full contact details asname, group leader/supervisor, department address and e-mail, will be considered. We do not consider applications fromPharmaceutical Companies or Universities outside Sweden.

The course is full time studies Monday to Friday from 8 am to 5 pm. Location at KI Campus, Solna.Ytterligare information : Leading International specialists such as Prof Jann Hau, Vera Baumans, René Remie and Ricardo Feinstein will lectures within theirfields. Written and practical examinations are included.

Kursansvarig : Karin SandstedtKomparativ medicin

[email protected]

Kontaktpersoner : Dude GigliottiKomparativ [email protected]

Berzelius väg 13

171 77STOCKHOLM

Title : Apoptosis: Theory and Methods



ForskarnivåNivå : Institute of Environmental MedicineKursansvarig institution :

Särskild behörighet : After the course the students will be able to use the knowledge of the principles, different mechanisms andKursens lärandemål :

methods currently guiding research in cell death (apoptosis). Since during the course all students will present and discuss their PhDprojects, the obtained knowledge will help them to avoid methodological mistakes and develop their own projects.

Theoretical: The lectures will open with an introduction to cell death and an examination of the relativeKursens innehåll : significance of apoptosis in biology and medicine. They will then discuss the latest results available on (i) molecular mechanisms of cell death, (ii) regulators of cell death and survival, (iii) role of different intracellular compartments in apoptosis, (iv) role of proteasesin apoptosis, (v) phagocytosis in apoptosis, (vi) inducers of apoptosis, with particular emphasis on anti-cancer chemotherapy, (vii)inhibitors of apoptosis, with particular emphasis on therapeutic strategies for neurodegenerative disorders, (viii) apoptosis in immunesystem, (ix) relevance to toxicology, (x) oxidative stress and apoptosis, (xi) apoptosis and cell cycle regulation, (x) methods fordetection of apoptosis. Practical: The students will work through 5 projects during the week. (1) Assessment of cell viability. (2)Assessment of apoptosis by examination of the nucleus (morphology, chromatin degradation). (3) Analysis of apoptosis by FACS.(4) Analysis of protease activation. (5) Analysis of mitochondrial changes

Lectures, project work, laboratory work, discussions and presentations of students PhD projects.Arbetsformer : Oral examination.Examination :

Lectures, project work and laboratory work are compulsory. If a student misses a compulsory part of theObligatoriska moment : course, this can be completed at the next course occasion.

25 - 30Antal studenter : Selection of students will be based on their motivation of the significance for them to take this course.Urval av studenter :

Course will be held at the Institute of Environmental Medicine, Nobels väg 13.Ytterligare information :

Kursansvarig : Boris ZhivotovskyInstitutet för miljö[email protected]

Nobels väg. 13

17177Stockholm

Kontaktpersoner : Boris ZhivotovskyInstitutet för miljö[email protected]

Nobels väg. 13

17177Stockholm

Title : Human Cell Culture. Methods and Applications




Särskild behörighet : After the course, the students should be well acquianted with the theory and practice of cell culture.Kursens lärandemål :

Knowledge in basic and state-of-the-art methods applied to cell cultures. To have developed skills for bench work with cell cultureson an individual basis.

Cell culture reflecting stem, transit amplifying, differentiated and terminally differentiated tissue states;Kursens innehåll : Monolayer and organotypic culture involving one or more cell types. Applicability of cell cultures as alternatives to laboratory animalexperiments. Mechanisms regulating cell growth and viability, differentiation and apoptosis. Assessment of cell transformation toimmortal and malignant phenotypes. Isolation of specific cells, e.g., epithelial cells,characterisation of cultured cells. Handling andsterile techniques, choice of materials and media for cell culture, e.g., serum-dependent vs. serum-free culture conditions. Cellcloning and gene transfer. Practical handling of cultures: thawing/freezing, passage, expansion and long-term storage. Handling ofnormal and tumor tissue for optimizing obtainment of cultures. Tissue engineering practices. Transcriptomics, proteomics andinformatics methods for biomedical research with cell lines. Discussion of participants own culture experience and problems.

Lectures, laboratory work, IT-use and group discussions on pitfalls and possibilities with cell cultures.Arbetsformer : Literature studies and oral presentation of results for the course participants.Examination :

Presence at scheduled lectures and time allocated for oral examination of allparticipants is compulatory.Obligatoriska moment : Opportunity to follow missed lectures is possible at repeat courses twice a year (graduate courses 1202 and 1862). Based ondocumented participation in the lectures, the oral examination can be arranged separately with the course organizer.

10 - 15Antal studenter : The participants are selected based on 1) their motivation and 2) year of admission to doctoral education.Urval av studenter :

Ytterligare information :

Kursansvarig : Roland GrafstromInstitutet för miljömedicin

[email protected]

Kontaktpersoner : Roland GrafstromInstitutet för miljömedicin

[email protected]

Title : Transcultural Mental Health - screening, intervention and evaluation



ForskarnivåNivå : Department of Neurobiology, Care Sciences and SocietyKursansvarig institution :

Särskild behörighet : At the end of the module students will be able to: - identify transcultural mental health key concepts - discussKursens lärandemål :

transcultural research methods, some basic and relevant research obstacles, ethical issues, and factors determining the variationsin mental health among different immigrant groups - assess methods for transcultural mental health and mental health promotionsstrategies - reflect about own values and norms in research questions, methods, and outcomes and evalutation

Review relevant research literature. Some basic and relevant research obstacles, paradigms, ethical issues andKursens innehåll : questions in transcultural mental health research. An overview of different qualitative research methods, validity, trustworthiness,tranferability and implications of contextualized findings, an explorative case. Physiological, psychosocial and diagnosticmeasurement of mental health assessment among refugee groups, prospective design. How to perform a survey based on register:Migration, access to employment and mental health Circumstances of and treatment and other services provided for patients withmental illness in a multicultural area, skills in using traditional and internet tools in collecting data

The course will consist of 1 week, fulltime, and 1 week of reading material before the start. Leaning activities includeArbetsformer : lectures, group work, video-conference lecture and discussion, individual assignments and and interactive seminars

Individual project/thesis description, title and study area; study design and methods. Oral presentation of group workExamination : It is compulsory to attend all the lectures. Absence will be compensated for by extra individualObligatoriska moment :

assignments provided by the course organizers10 - 20Antal studenter :

Criteria is own motivation to participate in the course and as PhD studentUrval av studenter : The course is fulltime, in English, morning with webbased lectures by different teachers and in theYtterligare information :

afternoon individual and group work, follow up questions to answer according to each lecture. It is possible to use own data whenanalysing data. In charge of the course: Solvig Ekblad

Kursansvarig : Solvig EkbladInstitutionen för lärande, informatik, management och [email protected]

Berzelius väg 3, plan 4

171 77Stockholm

Kontaktpersoner : Anna SillenInstitutionen för neurobiologi, vårdvetenskap och samhälle08-524 868 [email protected]

Title : Developmental and Perinatal Physiology



ForskarnivåNivå : Department of Cell and Molecular BiologyKursansvarig institution :

Särskild behörighet : Basic knowledge in developmental biology and perinatal physiology, including clinical applications. SomeKursens lärandemål :

deeper insight in ongoing research. Introduction to experimental methodologies (as choosen by the student from the workshop-list). Lectures: Embryology, Placentation, Developmental Endocrinology, Respiratory Control, Kidney Development,Kursens innehåll :

Developmental Neurobiology. Workshops: In vivo Model Systems, In vitro Systems, Imaging Techniques, Physiological Monitoring,Endocrine and Cell Expression.

Lectures, Research Workshops and SeminarsArbetsformer : Poster or Oral presentations by the studentsExamination :

Lectures and Workshops are compulsory. Absence can be compensated by short written essays on theObligatoriska moment : subject.

12 - 14Antal studenter : The selection is based on the relevance of the course content for the doctoral project and the personalUrval av studenter :

motivation letter to attend the course.The course takes place at the University of Toronto in Canada. The course may be able to sponsor part orYtterligare information :

all of the travel and accommodation costs for participating doctoral students from KI. This will be known at the point of admission inthe beginning of the summer of 2012. The course director is Ola Hermanson, email [email protected].

Kursansvarig : Matti NikkolaInstitutionen för cell- och molekylärbiologi

[email protected]

Kontaktpersoner : -

Title : Basic Course in Medical Statistics



ForskarnivåNivå : Department of Learning, Informatics, Management and EthicsKursansvarig institution :

Särskild behörighet : The course participants shall after the course be able to perform basic summaries, analyses andKursens lärandemål :

presentation of data, as well as have enhanced their ability to recognise, understand and critically view the statistics being presentedin medical articles.

The course is an introduction to basic statistical principles and how statistics play a part in medical research.Kursens innehåll : Concepts being treated are hypothesis, type I error, type II error, estimates, measurement of dispersion, regression analysis,inference making and how to present the results.

The course will consist of four scheduled half or whole days per week for two weeks. Lectures will be mixed withArbetsformer : seminars, where the course participants have group discussions, and manual exercises. The rest of the time will be spent workingon computer based exercises and reading the course literature.

Course requirements: - Correct answers on the computer based exercises. - Active participation in the seminars. Examination : Attendance is mandatory for the seminars. If the student is absent, he or she can compenste the absenceObligatoriska moment :

by handing in written answers to questions concerning the compulsory moments.35 - 40Antal studenter :

The selection for this general basic science course will be based on (1) your ranking of the applied course and Urval av studenter : (2) your registration date as a PhD student at Karolinska Institutet. Please make sure that you have put in the correct registrationdate for doctoral education at KI in your personal profile and that you have ranked the courses you have applied for.

The course will consist of four scheduled half or whole days per week for two weeks. Course dates: 3/12 - Ytterligare information : 4/12, 6/12 - 7/12, 10/12 - 11/12, 13/12 - 14/12; 2012 OBS! This course will also be given as a distance course, please see coursenumber 2609.

Kursansvarig : Mesfin TessmaInstitutionen för lärande, informatik, management och etik

[email protected]

Kontaktpersoner : Margareta Krook-BrandtInstitutionen för lärande, informatik, management och [email protected]

Title : Philosophy of science and research ethics




NoSärskild behörighet : The objective of this course is for the doctoral student to gain a basic understanding of the philosophy ofKursens lärandemål :

science and insight into and understanding of key ethical theories, principles and guidelines related to research and thereby begiven the opportunity to reflect on the ethical aspects of his/her own research. The objective is also to provide the doctoral studentwith an understanding of what is good research practice, and also an understanding of the boundary between what is ethicallyacceptable or unacceptable in terms of experimentation with human beings and animals. After completing the course, the researchstudent should: -be able to give an account of the positions relative to the philosophy of science and research ethical theories,principles and, to some extent current guidelines -know the most important terms within the philosophy of science and demonstrateknowledge of common problem situations in research ethics and of the ethical tools used to manage conflicts concerning researchethics -be able to analyse ethical conflicts in research and see the connection between the philosophy of science and researchethics -be able to construct sustainable research ethical arguments for or against a specific course of action -have developed anethical approach to research

The course includes the following: -Key ethical principles and theories of research -Fundamental values forKursens innehåll : empirical research, and standards of good scientific practice -Experiments on humans, including a review of informed consent, itsethical basis, and the pros and cons of practices for informed consent -Ethical tests and guidelines on how to conduct ethicalresearch, such as the Helsinki Declaration -Ethics and the use of laboratory animals, including arguments for and against usinganimals for research purposes, as well as the three Rs -Handling of authorship in scientific writing -Conflicts of interest in research -Key scientific terms and positions

Introducing lectures, group work and general discussions.Arbetsformer : - The doctoral students write a short informal essay on a scientific or research ethical theme related to their ownExamination :

research. - Attendance is mandatory for the group work and general discussions. - If the student is absent, he or sheObligatoriska moment :

can compenste by handling in written answers concerning the cases that have been discussed.30 - 35Antal studenter :

The selection for this general basic science course will be based on (1) your ranking of the applied course andUrval av studenter : (2) your admission date to doctoral education at Karolinska Institutet. Please make sure that you have put in the correct registrationdate for doctoral education at KI in your personal profile and that you have ranked the courses you have applied for. Ytterligare information :

Kursansvarig : Niels LynoeInstitutionen för lärande, informatik, management och etik

[email protected]

Kontaktpersoner : Emma KarlssonInstitutionen för lärande, informatik, management och etik08-524 83 [email protected]

Title : Philosophy of science and research ethics




NoSärskild behörighet : The objective of this course is for the doctoral student to gain a basic understanding of the philosophy ofKursens lärandemål :

science and insight into and understanding of key ethical theories, principles and guidelines related to research and thereby begiven the opportunity to reflect on the ethical aspects of his/her own research. The objective is also to provide the doctoral studentwith an understanding of what is good research practice, and also an understanding of the boundary between what is ethicallyacceptable or unacceptable in terms of experimentation with human beings and animals. After completing the course, the researchstudent should: -be able to give an account of the positions relative to the philosophy of science and research ethical theories,principles and, to some extent current guidelines -know the most important terms within the philosophy of science and demonstrateknowledge of common problem situations in research ethics and of the ethical tools used to manage conflicts concerning researchethics -be able to analyse ethical conflicts in research and see the connection between the philosophy of science and researchethics -be able to construct sustainable research ethical arguments for or against a specific course of action -have developed anethical approach to research

The course includes the following: -Key ethical principles and theories of research -Fundamental values forKursens innehåll : empirical research, and standards of good scientific practice -Experiments on humans, including a review of informed consent, itsethical basis, and the pros and cons of practices for informed consent -Ethical tests and guidelines on how to conduct ethicalresearch, such as the Helsinki Declaration -Ethics and the use of laboratory animals, including arguments for and against usinganimals for research purposes, as well as the three Rs -Handling of authorship in scientific writing -Conflicts of interest in research -Key scientific terms and positions

Introducing lectures, group work and general discussions.Arbetsformer : - The doctoral students write a short informal essay on a scientific or research ethical theme related to their ownExamination :

research. - Attendance is mandatory for the group work and general discussions. - If the student is absent, he or sheObligatoriska moment :

can compenste by handling in written answers concerning the cases that have been discussed.30 - 35Antal studenter :

The selection for this general basic science course will be based on (1) your ranking of the applied course andUrval av studenter : (2) your admission date to doctoral education at Karolinska Institutet. Please make sure that you have put in the correct registrationdate for doctoral education at KI in your personal profile and that you have ranked the courses you have applied for. Ytterligare information :


[email protected]


Title : Medicinsk vetenskapsteori och forskningsetik


2012-10-29 -- 2012-11-02Datum : SvenskaSpråk :


NejSärskild behörighet : Målet med kursen är att den forskarstuderande ska få en grundläggande vetenskapsteorisk förståelse ochKursens lärandemål :

inblick i och förståelse av centrala forskningsetiska teorier, principer och riktlinjer och därmed få möjlighet att reflektera över etiskaaspekter av den egna forskningen. Målet är också att den forskarstuderande ska få en förståelse av vad som är god forskningssed,samt var gränsen går för vad som är etiskt oacceptabelt både vad gäller försök med människor och med djur. Denforskarstuderande ska efter att ha gått kursen: -kunna redogöra för vetenskapsteoretiska positioner samt forskningsetiska teorier,principer och, i viss mån, riktlinjer -känna till centrala vetenskapsteoretiska termer samt vanliga forskningsetiska problemsituationeroch de etiska verktygen för att hantera forskningsetiska konflikter -kunna analysera forskningsetiska konflikter och se kopplingenmellan vetenskapsteori och forskningsetik -kunna ge hållbara forskningsetiska argument för eller mot ett förfarande -ha utvecklat ettforskningsetiskt förhållningssätt

Kursen innehåller följande moment: -Centrala forskningsetiska principer och teorier -Grundläggande värderingarKursens innehåll : för empirisk forskning samt normer för god vetenskaplig sed -Försök med människor, inklusive en genomgång av informeratsamtycke, dess etiska grund och för- och nackdelar med rutiner för informerat samtycke -Etikprövningar och forskningsetiskariktlinjer, såsom Helsingforsdeklarationen -Försöksdjursetik, innefattande argument för och emot att använda djur förforskningsändamål, samt de tre R:en -Hantering av vetenskapligt författarskap -Intressekonflikter i forskningen -Centralavetenskapliga termer och positioner

Introducerande föreläsningar, grupparbeten och plenumdiskussioner.Arbetsformer : Deltagarna skriver en egen vetenskapsteoretisk eller forskningsetisk reflektion över sitt eget forskningsprojekt.Examination :

Vid frånvaro krävs särskilt utförliga svar på de fall som diskuterats. Gruppdiskussionerna ochObligatoriska moment : plenumdiskussionerna är obligatoriska.

30 - 35Antal studenter : Urvalet till denna allmänvetenskapliga baskurs baseras på (1) din rangordning av den sökta kursen och (2) detUrval av studenter :

datum som du antogs till forskarutbildning vid Karolinska Institutet. Se till att du har lagt in korrekt datum för antagning i dinpersonliga profil, samt att du rangordnat kurserna du sökt. Ytterligare information :


[email protected]


Title : Writing science and information literacy



ForskarnivåNivå : Karolinska Institutet University LibraryKursansvarig institution :

Särskild behörighet : After the course, you should: - be able to organize, write and revise a research report based on own data -Kursens lärandemål :

know how applications are evaluated and have some idea about what makes applications successful - have practiced writing aboutresearch for a general audience - be able to recognize and correct common structural and stylistic writing weaknesses - be aware ofethical considerations in connection with the writing process - know how to submit a paper and understand the scientificcommunication system - be able to analyze scientific problems from an information needs perspective - be able to apply theprinciples of medical information retrieval - know about medical sciences databases and other information resources - be able toretrieve, evaluate and cite the medical sciences literature - understand what Open Access implies

Scientific writing, Popular science writing, Grant writing, Thesis writing, Figures and tables, Revising structureKursens innehåll : and style, Ethical issues in writing, Publication process, Principles of medical information retrieval, Getting started with referencemanagement -- Endnote, Tips and tricks with Word, Literature evaluation tools for the medical sciences, Open Access

Individual writing and rewriting, lectures, working in pairs and groups, web-based teaching, demonstrations,Arbetsformer : computer exercises and individual study

Writing a grant application with popular science summary and rewriting (including references) based on peer andExamination : teacher feedback

The course writing assignment is obligatory and has to be submitted about 10 days BEFORE course start.Obligatoriska moment : All scheduled teaching is complusory (except where clearly stated otherwise). Absence can be compensated for by reading andindividual work after consultation with course leaders.

30 - 34Antal studenter : The selection for this general basic science course will be based on (1) your ranking of the applied course andUrval av studenter :

(2) your admission date to doctoral education at Karolinska Institutet. Please make sure that you have put in the correct registrationdate for doctoral education at KI in your personal profile and that you have ranked the courses you have applied for.

There is a writing assignment to hand-in about 10 days before course start.Ytterligare information :

Kursansvarig : david herronKarolinska Institutet [email protected]

Berzelius 7B

17177Stockholm

Kontaktpersoner : -

Title : Vetenskapligt skrivande och informationskompetens




Särskild behörighet : Efter kursen ska du: - kunna organisera, skriva och revidera en forskningsrapport baserad på egna data -Kursens lärandemål :

känna till hur ansökningar utvärderas och några av framgångsfaktorerna - ha prövat att skriva populärvetenskapligt - känna igenoch kunna korrigera de vanligaste strukturella och stilistiska svagheterna i text - vara medveten om etiska överväganden vidvetenskapligt skrivande - känna till ansökningsförfarandet och det vetenskapliga publiceringssystemet - kunna analyseravetenskapliga frågeställningar ur ett informationsperspektiv - kunna tillämpa principer för medicinsk databassökning - känna till ettantal biomedicinska databaser och andra informationsresurser - kunna söka, värdera och citera medicinsk vetenskaplig information - förstå vad Open Access innebär

Scientific writing, Popular science writing, Grant writing, Thesis writing, Figures and tables, Revising structureKursens innehåll : and style, Ethical issues in writing, Publication process, Principer för medicinsk databassökning, Introduktion till referenshantering --Endnote, Tips och råd i Word, Evalueringsverktyg för medicinsk vetenskap, Open Access.

Individuella skrivuppgifter och revision, föreläsningar, par- och grupparbeten, webbaserat lärande, demonstrationer,Arbetsformer : datorövningar och individuella studier. Obs. kursdelen som behandlar vetenskapligt skrivande hålls på engelska

Skrivande av en anslagsansökan (på engelska) med populärvetenskaplig sammanfattning (på svenska) samtExamination : bearbetning (med referenser) baserat på "peer"- och lärarkommentarer.

Skrivuppgiften är obligatorisk och måste inlämnas cirka 10 dagar FÖRE kursens början. Obligatoriska moment : 30 - 34Antal studenter :

Urval för denna allmänvetenskapliga baskurs görs genom (1) din rangordning av kursen och (2) datum förUrval av studenter : antagning till forskarutbildning vid KI. Se till att du har fyllt i korrekt datum för antagning i din personliga profil samt att du harrangordnat sökta baskurser.

Föreläsningar angående vetenskapligt skrivande är på engelska. Det finns en skrivuppgift att inlämnaYtterligare information : ungefär 10 dagar innan kursstart.


Berzelius 7B

17177Stockholm

Kontaktpersoner : david herronKarolinska Institutet [email protected]

Berzelius 7B

17177Stockholm

Title : Flow cytometry: from theory to application



ForskarnivåNivå : Department of Medicine, SolnaKursansvarig institution :

Särskild behörighet : Through this one-week course, the participants will acquire the knowledge of flow cytometry principles. TheyKursens lärandemål :

will know flow cytometric sample preparation and analysis, protocol set-up, as well as data interpretation.The course covers basic knowledge and main applications of flow cytometry, and contains both lectures andKursens innehåll :

laboratory/group work. Experts in different fields of flow cytometric application are invited to give the lectures. The participants will beable to learn: a) Principles of flow cytometry: working mechanisms of flow cytometer; molecular and cellular probes for flowcytometry; quality control; and safty procedures and intrument maintainance. b) Basic skills: flow cytometric protocol design; samplehandling and storage; data processing and analysis, and data presentation. c) Major applications of flow cytometry in biomedicalresearch: leukocyte phenotyping, endothelial cell analysis, stem cell analysis, apotosis, platelet measurement, cell function analysis(including membrane potential, oxidative metabolism, intracellular calcium mobilization, pH, and intracellular organelles), as well asnucleic acid analysis.

The course includes 28 hr lectures and 12 hr hands-on lab work.Arbetsformer : The exam will consist two parts: a 30-min written test on flow cytometric principles; and a 60 min hands-on lab workExamination :

examining flow cytometric lab skillsThe participants must attend hands-on lab sections during two afternoons. The students who have missedObligatoriska moment :

these sections can book extra lab section time within 4 weeks to compensate the absence.20 - 32Antal studenter :

The course used to receive far more applications than the maximal course slots of 32. Selection of theUrval av studenter : participants is made according to: 1) How relevant is flow cytometry to the thesis project? 2) How urgent is the flow cytometrytraining for her/his project work? 3) Has the student applied for the course before?

Course held during week 39 (September 24 - 28, 2012; Monday - Friday 8:30 - 17:00). Lecture hallYtterligare information : booked: Thoraxaulan, N2:U1 at Karolinska University Hospital-Solna. Lectures will be given by 14-15 lecturers, usaually half ot themfrom institutions outside KI, with one or two from abroad. All the lecturers are well-established flow cytometrists on their lecturesubjects. The course has been given 1-2 times/year at KI for 11 years. It has been highly appreciated by the participants through theyears, with a median general satisfaction score never below 8 (out of 9).

Kursansvarig : Nailin LiInstitutionen för medicin, [email protected]

Clinical Pharmacology UnitKarolinska University Hospital-Solna17176Stockholm

Kontaktpersoner : Nailin LiInstitutionen för medicin, [email protected]

Clinical Pharmacology UnitKarolinska University Hospital-Solna17176Stockholm

Title : Rörelseapparaten - klinisk utvärdering av funktion och behandling



ForskarnivåNivå : Department of Molecular Medicine and SurgeryKursansvarig institution :

Särskild behörighet : Kunskaper: Kunskaper om metoder, försöksplanering och statistisk bearbetning av material inom kliniskaKursens lärandemål :

forskningsprojekt som berör rörelseorganens sjukdomar och skador. Färdighet: Kunna framställa och värdera en forskningsplan förett projekt inom rörelseorganens sjukdomar. Förhållningssätt: Ha lärt sig ett vetenskapligt och kritiskt förhållningssätt till denvetenskapliga litteraturen inom området för rörelseorganens sjukdomar och skador.

Klinisk utvärdering av funktion och behandling inom rörelseorganens sjukdomar och skador.Kursens innehåll : Katedrala föreläsningar, gruppövningar kring ett tänkt forskningsprojekt.Arbetsformer :

Kursdeltagarna redovisar de forskningsprojekt som de arbetat med under kursen och projektet diskuteras med övrigaExamination : kursdeltagare och en lärarpanel bestående av kursledningen och speciellt inbjudna experter. Under denna diskussion testaskursdeltagarnas kunskaper, färdigheter, värderingsförmågor och förhållningssätt utifrån lärandemålenObligatoriska moment :

5 - 20Antal studenter : Urval görs utifrån skriven motivering.Urval av studenter :

Kurslokal: Eugneiahemmet T3, Karolinska universitetssjukhuset Solna. Ytterligare information :

Kursansvarig : Lars WeidenhielmInstitutionen för molekylär medicin och kirurgi

[email protected]

Kontaktpersoner : Annika Kling OsterlundInstitutionen för molekylär medicin och kirurgi

Annika.Kling [email protected]

Title : Epidemiology I: Introduction to epidemiology



ForskarnivåNivå : Department of Medical Epidemiology and BiostatisticsKursansvarig institution :

Särskild behörighet : After successfully completing this course students are expected to be able to: -give examples of theKursens lärandemål :

contribution of epidemiology to science and discuss the importance of epidemiology as a research discipline. -estimate and in ageneral way interpret measures of disease occurrence and measures of association, and describe how a specific measure isgoverned by the study design. -explain strengths and weaknesses of common epidemiological study designs. -identify and explainpossible sources of bias in epidemiological studies. -describe theoretical models for causation and discuss the principles of causalmechanisms. -apply knowledge of epidemiological concepts when critically reviewing scientific literature. Learning outcomes areclassified according to Bloom´s taxonomy: knowledge, comprehension, application, analysis, synthesis, and evaluation.

The course gives an introduction to epidemiological theory and practice. It comprises basic principles regardingKursens innehåll : design, interpretation, and analysis of epidemiological studies. It introduces the concept of causation, concepts related to measuresof disease occurrence and measures of association, common designs for epidemiological studies (with main focus on cohortstudies), and the role of bias.

The course focuses on active learning, i.e. putting knowledge into practice and critically reflecting upon theArbetsformer : knowledge, rather than memorising facts. Different strategies for teaching and learning will be used, such as lectures, groupdiscussions and various forms of group exercises on selected topics.

To pass the course, the student has to show that the learning outcomes have been achieved. Assessments methodsExamination : used are group assignments along with written and oral individual tasks. The examination is viewed as contributing to thedevelopment of knowledge, rather than as a test of knowledge. Students who do not obtain a passing grade in the first examinationwill be offered a second chance to resubmit the examination within two months of the final day of the course. Students who do notobtain a passing grade at the first two examinations will be given top priority for admission the next time the course is offered.

The examination tasks are compulsory. Obligatoriska moment : 12 - 25Antal studenter :

Eligible registered doctoral students will be prioritized according to 1) the relevance of the course content forUrval av studenter : their research, and 2) the stated motivation for attending the course. To be considered, please submit a completed application formand give all information requested, including a description of current research and motivation for attending, as well as an account ofprevious courses taken.

Course dates: October 16th, 18th ,22nd, 23rd and 25th, 2012Ytterligare information :

Kursansvarig : Katarina BälterInstitutionen för medicinsk epidemiologi och biostatistik

[email protected]

Kontaktpersoner : Marie BeckemanInstitutionen för medicinsk epidemiologi och biostatistik

[email protected]

Title : Biostatistics I: Introduction for epidemiologists




Särskild behörighet : After successfully completing this course students should be able to: - define the concept of probability, lawsKursens lärandemål :

of probability, and make simple probability calculations. (S2) - suggest a statistical distribution to describe a naturally occurringphenomonen and evaluate the appropriateness of the distribution given real data. (S3) - present appropriate descriptive statistics foran epidemiological study. (S2) - explain the difference between hypothesis testing and interval estimation and the relation betweenp-values and confidence intervals. (S3) - suggest an appropriate statistical test for a comparison of two groups, perform thehypothesis test using standard statistical software, and interpret the results. (S3) - estimate and interpret three alternative measuresof association between binary exposures and binary outcomes and discuss the relative merits of each measure for a given researchquestion. (S3) - explain the concept of confounding in epidemiological studies and demonstrate how to control/adjust forconfounding using stratified analysis. (S2) - explain the basis of the linear regression model, fit a linear regression model usingstandard statistical software, assess the fit of the model, and interpret the results. (S2) Learning outcomes are classified accordingto Bigg's structure of the observed learning outcome (SOLO) taxonomy: (S1) uni-structural, (S2) multi-structural, (S3) relational, and(S4) extended abstract.

The course introduces classical statistical concepts and methods with emphasis on methods used inKursens innehåll : epidemiology and public health. Topics covered include: the importance of statistical thinking; types of data (nominal, binary, discreteand continuous variables); data summary measures; contingency tables; graphical representations; notions of probability; probabilitymodels (distributions); principles of statistical inference; parameter estimation (mean, proportion (prevalence), incidence and ratios);concepts of confidence intervals and hypothesis tests; and a general introduction to correlation and linear regression models.

Lectures, exercises focusing on analysis of real data using statistical software, exercises not requiring statisticalArbetsformer : software, group discussions, literature review.

The course grade is based mainly on a written examination, but group tasks and individual written assignments areExamination : also used. The course is divided into two parts, and each part will be examined separately. To pass the course, a student must passboth parts. Students who fail will be offered a re-examination within 2 months of the final day of the course. Students who fail there-exam will be given top priority for admission the next time the course is offered. If the course is not offered during the followingtwo academic terms then another re-examination will be scheduled within 12 months of the final day of the course. Obligatoriska moment :

12 - 25Antal studenter : Eligible registered doctoral students will be prioritized according to 1) the relevance of the course content forUrval av studenter :

their research, and 2) the stated motivation for attending the course. Submit a completed application form and give all informationrequested, including a description of current research and motivation for attending, as well as an account of previous courses taken.Also state what statistical software you have experience in.

Course dates: September, 19, 20, 21, 24, 25 2012. Exam 1, September 27 2012. October, 3, 4, 5, 8, 9Ytterligare information : 2012. Exam 2, October 11. The statistical software Stata will be used throughout the course, and participants are expected topossess basic knowledge of Stata or any statistical software relevant for Biostatistics.

Kursansvarig : Yudi PawitanInstitutionen för medicinsk epidemiologi och biostatistik

[email protected]


[email protected]

Title : Signal transduction in brain diseases



ForskarnivåNivå : Department of NeuroscienceKursansvarig institution :

Särskild behörighet : Knowledge and understanding: After completion of the course, the graduate student should be able toKursens lärandemål :

understand and describe the molecular basis of specific neuropsychiatric and neurodegenerative disorders (cf. below), withparticular emphasis on the mechanisms of synaptic plasticity related to these pathological conditions. The student should also beable to understand current therapies, their efficacy and their limits. Skills and professional attitudes: The students should be able tocritically evaluate and discuss advantages and disadvantages of potential interventions on signal transduction processes for thetreatment of neuropsychiatric and neurodegenerative disorders.

The course describes alterations in signaling associated to neuropsychiatric and neurodegenerative disorders,Kursens innehåll : including schizophrenia, depression, drug addiction, Parkinson's disease and Alzheimer's disease. The potential relevance of suchalterations for the etiology and the therapy of the various diseases will be discussed.

The course will be organised as a series of presentations held by researchers working in various fields of molecularArbetsformer : neuroscience and neuropharmacology. There will be four days of lectures and a final fifth day for the examination. Each lecture willconsist of two hours of presentation followed by 45 min of discussion between the students and the speaker. Students will receivespecific literature to prepare the discussion.

Written examinationExamination : 1) Discussion: Students will be divided into groups of 4 and each group will be asked to present twoObligatoriska moment :

questions to discuss with each lecturer at the end of the presentations. 2) Individual written exam on the fifth day. To compensate forabsence from a compulsory part the graduate student will have to report on a specific lecture or write an extra exam.

15 - 25Antal studenter : Written motivation and degree of completion of graduate education (date of registration)Urval av studenter :

The course will last a week. Lectures and discussions are scheduled from Monday to Thursday duringYtterligare information : morning (9:00-12.00) and afternoon (13.00-16.00). A written examination will take place on Friday morning. The course will beorganized within the KI Campus. There may be some changes in schedule, due to the participation of foreign speakers (at leasttwo).

Kursansvarig : Gilberto FisoneInstitutionen för [email protected]

Kontaktpersoner : Gilberto FisoneInstitutionen för [email protected]

Title : From tumor immunology to immune and gene therapy of cancer



ForskarnivåNivå : Department of Oncology-PathologyKursansvarig institution :

Särskild behörighet : After the course is completed the students will be able to; 1) explain different aspects of tumor immunology,Kursens lärandemål :

2) compare advantages and disadvantages of different immune therapy strategies, 3) explain mechanisms of immune escape, 4)hypothesize how different immune-based regimens may affect outcome in patients with cancer.

This course covers basic and applied immunology and a current review of experimental research and clinicalKursens innehåll : application of tumor immunology. Both pre-clinical and clinical aspects of cancer vaccines, adoptive cell therapy, and antibodytherapy will be discussed. Development of novel therapies through genetic modification of cytotoxic lymphocytes will be presented.Features of immune surveillance, immune escape, and how to overcome such suppressive mechanisms will also be discussed.Planning, performing, and monitoring of clinical trials will be covered. One to two days are dedicated to lectures from invitedinternational experts in the field.

Lectures. seminars and group discussions.Arbetsformer : Written examinationExamination :

Obligatoriska moment : 12 - 30Antal studenter :

Selection is based on field of research. This is an relatively advanced course and priority will be given toUrval av studenter : students with good background knowledge in immunology. The course also entails clinical research why 1/3 of seats will bereserved for clinicians.

Monday-friday; kl9-16 CCK lecture hall R8:00 Four international speakers will be invited in addition toYtterligare information : 10-12 speakers from Karolinska

Kursansvarig : Rolf KiesslingInstitutionen för [email protected]

Kontaktpersoner : Andreas LundqvistInstitutionen för onkologi-patologi

[email protected]

Title : Molecular Immunology



ForskarnivåNivå : Department of Microbiology, Tumor and Cell BiologiKursansvarig institution :

Särskild behörighet : After the course, the student should be able to relate their own research project to the cutting-edgeKursens lärandemål :

developments in other areas of immunology research. Furthermore, they should have gained increased experience in preparing andpresenting novel information about an immunological problem or a specific technique to their fellow students.

The course is given during 2 weeks. Invited national and international lecturers give their views on selectedKursens innehåll : problems, or techniques, in immunology. The seminars take off from basic facts, but the speakers are encouraged to move on tocurrent problems, and to focus on both scientific and methodological aspects. To merit 3 full ECTS points for the course, studentswill be asked, in a group project work, to study an immunological method or problem deeply at the theoretical level and lecture aboutthis method to the fellow students. At the end of the course, a written and an oral presentation is expected from all students.

Lectures, group work, oral and written presentationsArbetsformer : Evaluation of oral and written presentation of project work. Specific contibution of each group participant will beExamination :

investigated and evaluated. A short written exam based on the content of the course.Oral presentations at the end of the course. Written project work and written test. If a student misses theObligatoriska moment :

presentation, a special presentation with the course leader will be arranged.8 - 25Antal studenter :

Selection of students is based on 1.Motivation to attend the course 2.Date of acceptance as doctoral student. Urval av studenter : The course is separated into two parts (3+3 days) and will be located at the Solna campus.Ytterligare information :

Kursansvarig : Robert WallinInstitutionen för medicin, [email protected]

Kontaktpersoner : Robert WallinInstitutionen för medicin, [email protected]

Title : Oxidative stress: Disease, Methods and Concepts




Särskild behörighet : After the course the students will possess updated and basic knowledge in the rapidly evolving oxidativeKursens lärandemål :

stress field. By poster presentations and discussion sessions the student will get training in critical appraisal of the role of oxidativestress in disease and aging relevant also to their own research. The student will learn state of the art methodological approachesand when and where to use them.

-The chemistry and biochemistry of endogenous oxidants and antioxidants. -Individual endogenous antioxidantKursens innehåll : defence principles and the mechanisms of their action. -Redox regulation in coordinating basal signalling and gene regulation aswell as adaptive phenotypic alterations during tissue oxidative stress. -Disease mechanisms where oxidative stress and antioxidanttherapies have been indicated. Cardiovascular and neurological disorders. -Oxidative stress and aging. -Radiation therapy inducedoxidative stress. -Antioxidants in nutrition. -State of the art methodology in measuring oxidative stress endpoints in DNA, lipids andproteins.

The course consists of lectures, seminars, laboratory demonstrations and individual presentations.Arbetsformer : Oral examinationExamination :

Lectures and seminars are compulsary. Absence can be compensated by an essay on the correspondingObligatoriska moment : subject.

12 - 20Antal studenter : Motivation and reserach profileUrval av studenter :


Kursansvarig : Ralf MorgensternInstitutet för miljö[email protected]

Nobels väg 13

17177Solna

Kontaktpersoner : Anna MarcusInstitutet för miljö[email protected]

Title : Cytokines in inflammation



ForskarnivåNivå : Department of Clinical NeuroscienceKursansvarig institution :

NoneSärskild behörighet : Aim To provide an increased understanding of the function of cytokines in the healthy immune system and inKursens lärandemål :

different diseases. Objectives At the end of the course the particpiant should be able to: - select adequate experimental methods toanalyse cytokines depending on the scientific question - understand the relevance of cytokines for analysis in your research project -compare and contrast the function of cytokines in different organs and different diseases - explain how a disease can be treated withdrugs that target cytokines - describe a future treatment of a disease, where the modification of the cytokine pattern is the target

Learning how to measure cytokine responses in different ways and understanding the function of cytokines inKursens innehåll : immunological networks

The course is partly theoretical, partly practical, where lectures and laboratory exercises are integrated. Time is alsoArbetsformer : allocated for discussing lab results and lectures.

To pass the course, a participant has to: - actively participate in the oral discussions during the last day of the course Examination : - on the last day of the course hand in a written report in which you discuss which cytokines you would like to analyse in your ownresearch project, motivate why, and describe and discuss which methods you would choose from the methods presented during thecourse.

All practical sessions are compulsory. Absence from several practical sessions cannot be compensatedObligatoriska moment : for, but absence from one session can be compensated for in subsequent sessions.

12 - 28Antal studenter : Selection will be based on motivation expressed in personal letter. Priority will be given to 1) PhD studentsUrval av studenter :

working in the field of immunology and 2) early stage students (year 1-2).Kl.09.00-16.00 all days 3 international invited experts + KI experts for lectures, local staff for practicalYtterligare information :

work.

Kursansvarig : Daniel KetelhuthInstitutionen för medicin, Solna

[email protected]

Kontaktpersoner : Alexandra BäcklundInstitutionen för medicin, Solna

[email protected]

Title : Basic course in Tumor Biology andf Oncology




Särskild behörighet : This is a basic course for all PhD-students in the field. After the course the students will have anKursens lärandemål :

understanding of the cancer problem, the modern view what cancer is, from a clinical and basic science view. You will get the basicfoundations of cancer biology as well as aquire some ability to discuss and understand advanced problems in cancer biology. Youwill have an idea which are the current most important problems to solve in cancer, to improve diagnosis, prevention, treatment andquality of life. The over all aim of the course is to form a bridge between pre-clinical and clinical aspects of tumor biology andoncology for PhD students and to provide the students an understanding of all aspects of the cancer problem. This course is a basicintroduction to modern cancer research and is recommended to all PhD students within basic and clinical cancer research.

The course will describe the causes as well as the consequences of the transformation of a normal cell into itsKursens innehåll : malignant counterpart, in order to create an understanding of cancer --from molecule to patient--, eventually also discussing themanagement and treatment of malignant diseasesThe topics of the course include genetics, the cell cycle, apoptosis, immunology,diagnostics and treatment, all topics presented from the cancer perspective. There will be focus on a few malignant diseases,described in more detail serving as models for basic concepts of Tumor Biology and Oncology, including molecular genetics,curative treatment and palliative care, psychosocial aspects of cancer, ethics and epidemiology. All seminars and demonstrationsare compulsory, also some lectures, as well as the written examination. Single missed occasions can be compensated during thecourse after discussion with te course director.

The course consists of lectures, group seminars, group discussions and demonstrations. Full time during twoArbetsformer : consecutive weeks.

Written examination with a focus on understanding of concepts, relations and how and how problems are dealt withExamination : in cancer research.

This course is full time for two weeks. All seminars and demonstrations are compulsory, also someObligatoriska moment : lectures, as well as the written examination. Single missed occasions can be compensated during the course after discussion with tecourse director.

15 - 30Antal studenter : Selection of students will be based on the written motivation.Urval av studenter :

Location: Radiumhemmet Lecture Hall in Radiumhemmet floor 1, Karolinska Universitetssjukhuset, Solna.Ytterligare information : The course administration is sited at Karolinska University Hospital, Solna, Radiumhemmet, floor 1 and can be reached by e-mail [email protected]. The lectures are give by some of the most reputed cancer scientists at the Karolinska. One appreciatedpart, especially among pre-clinical students, has been the opportunity to meet cancer patients.

Kursansvarig : Svetlana LagercrantzInstitutionen för molekylär medicin och [email protected]

Trastvägen 24

18279Stocksund

Kontaktpersoner : -

Title : Application of Epidemiological Methods in Aging Research




Särskild behörighet : The course offers an opportunity to learn epidemiological methods and their applications to research onKursens lärandemål :

aging. After completion of the course, the students should be able to understand different epidemiological methods, to recognize theimportance of epidemiological approaches in research of aging and health, and to be updated with the knowledge of epidemiology ofcommon geriatric disorders such as Alzheimer¿s disease and Parkinson¿s disease.

The one-week course consists of two parts. Part I (2 days) deals with essential concepts of modernKursens innehåll : epidemiology, epidemiological measurements, and epidemiological approaches involving descriptive (ecological and cross-sectionalstudies), analytical (e.g., case-control and cohort studies), and experimental (e.g., randomized controlled clinical trials) methods.Part II (3 days) will present ¿state-of-the-art¿ review lectures of advancements in epidemiological research of aging-relateddisorders by taking dementia (Alzheimer¿s disease and vascular dementia) and Parkinson¿s disease as examples.

The pedagogic learning activities will consist of lectures, group/individual discussions, and critical readings andArbetsformer : presentations of selected epidemiological literature.

Presentation of assignments in the group, and individual written report (evaluation and critical comments of selectedExamination : articles).

Active attendance is mandatory for lectures and group work. If the student is absence, it is possible for theObligatoriska moment : student to compensate the absence by handing in written answers to the key questions that have been discussed. Submission ofwritten report is essential for obtaining the credits.

15 - 20Antal studenter : The students will be selected based on the relevance on aging epidemiology within which the student isUrval av studenter :

working on. Basic epidemiological background is mandatory, research experience in aging is meritorious.The course will be given during one week (Monday to Friday), 9 am to 4:30 pm. Specific content 2012:Ytterligare information :

Professor Laura Fratiglioni will give several lectures. Laura Fratiglioni is a world famous specialist in the field of neuroepidemiology. Adress: Aging Research Center (ARC), Gävlegatan 16, 8th floor, Stockholm

Kursansvarig : Laura FratiglioniInstitutionen för neurobiologi, vårdvetenskap och samhä[email protected]

Kontaktpersoner : Huixin WangInstitutionen för neurobiologi, vårdvetenskap och samhälle

[email protected]

Chengxuan QiuInstitutionen för neurobiologi, vårdvetenskap och samhä[email protected]

ARC, Gävlegatan 16

11330Stockholm

Title : Epidemiology III. Analysis and interpretation of epidemiological data




Knowledge equivalent to Epidemiology I, Epidemiology II and Biostatistics I or corresponding courses.Särskild behörighet : Knowledge and understanding: At the end of the course the student should, in a self-directed manner, beKursens lärandemål :

able to describe and understand principles of causal inference. Skills and abilities: The student should be able to apply theirknowledge and understanding regarding epidemiological issues and be able to interpret the concepts confidence interval, p-value,multiple analyses, à priori probabilities, Bayesian analysis and meta-analysis. The student can be expected to communicate theirareas of expertise within and outside the scientific society. Scientific approach and ablility to make judgements: The student should,mainly independently, be able to evaluate, synthesise and draw conclusion from available scientific data concerning specificresearch questions.

The course focus on issues related to causal inference, general principles of epidemiological data analysis andKursens innehåll : meta-analysis.

Lectures, group discussions and various forms of group exercises on selected topics, will be used. The courseArbetsformer : focuses on active learning, i.e. putting knowledge into practice and critically reflecting upon the knowledge, rather than memorisingfacts.

To pass the course, the student has to show that the learning outcomes have been achieved. Assessments methodsExamination : used are group assignments along with written individual tasks. The examination is viewed as contributing to the development ofknowledge, rather than as a test of knowledge. Students who do not obtain a passing grade in the first examination will be offered asecond chance to resubmit the examination within two months of the final day of the course. Students who do not obtain a passinggrade at the first two examinations will be given top priority for admission the next time the course is offered. Obligatoriska moment :

12 - 25Antal studenter : Prerequisite knowledge equivalent to Epi I, Epi II, and Biostat I or corresponding courses. Eligible registeredUrval av studenter :

doctoral students will be prioritized according to 1) the relevance of the course content for their research, and 2) the statedmotivation for attending the course. To be considered, submit a completed application form and give all information requested,including a description of current research and motivation as well as an account of previous courses.

Course participants are expected to attend class at Karolinska Institutet Campus Solna each course dayYtterligare information : 9.00-16.00 (i.e., November 26, 28, 30, December 3, 5). The learning activities within the course will consist of lectures, groupsessions as well as individual assignments to be performed at home.

Kursansvarig : Lars AlfredssonInstitutet för miljömedicin

[email protected]

Kontaktpersoner : Anita BerglundInstitutet för miljömedicin

[email protected]

Title : Biostatistics III: Survival analysis for epidemiologists




Epidemiology I (course 1577), Biostatistics I (course 1579), and Biostatistics II (course 1513) or equivalentSärskild behörighet : courses and practical experience applying statistical models.

After successfully completing this course students should be able to: - propose a suitable statistical model forKursens lärandemål : assessing a specific research hypothesis using data from a cohort study, fit the model using standard statistical software, evaluatethe fit of the model, and interpret the results. (S4) - explain the similarities and differences between Cox regression and Poissonregression. (S3) - understand the concept of timescales in statistical models for time-to-event data, be able to control for differenttimescales using standard statistical software, and argue for an appropriate timescale for a given research hypothesis. (S3) -understand the concept of confounding in epidemiological studies and be able to control/adjust for confounding using statisticalmodels. (S3) - apply and interpret appropriate statistical models for studying effect modification and be able to reparameterise astatistical model to estimate appropriate contrasts. (S3) - critically evaluate the methodological aspects (design and analysis) of ascientific article reporting a cohort study. (S3) Learning outcomes are classified according to Bigg's structure of the observedlearning outcome (SOLO) taxonomy: (S1) uni-structural, (S2) multi-structural, (S3) relational, and (S4) extended abstract.

This course introduces statistical methods for survival analysis with emphasis on the application of suchKursens innehåll : methods to the analysis of epidemiological cohort studies. Topics covered include methods for estimating patient survival (life tableand Kaplan-Meier methods), comparing survival between patient subgroups (log-rank test), and modelling survival (primarilyPoisson regression and the Cox proportional hazards model). The course addresses the concept of 'time' as a potential confounderor effect modifier and approaches to defining 'time' (e.g., time since entry, attained age, calendar time). The course will emphasisethe basic concepts of statistical modelling in epidemiology, such as controlling for confounding and assessing effect modification.

Lectures, exercises focussing on analysis of real data using statistical software, exercises not requiring statisticalArbetsformer : software, group discussions, literature review.

The course grade is based solely on a written examination. The examination will contain two sections and a passingExamination : grade must be obtained for each section in order to obtain a passing grade for the course. Students who do not obtain a passinggrade on both sections and wish to take the examination again must retake the entire examination (i.e., both sections) even if theypreviously obtained a passing grade on one of the two sections. The focus of the exam will be on understanding concepts and theirapplication to analysis of epidemiological studies rather than mathematical detail. The course examination will be held within oneweek of the final day of the course. Students who do not obtain a passing grade in the first examination will be offered a secondexamination within 2 months of the final day of the course. Students who do not obtain a passing grade at the first two examinationswill be given top priority for admission the next time the course is offered. If the course is not offered during the following twoacademic terms then a third examination will be scheduled within 12 months of the final day of the course.Obligatoriska moment :

12 - 25Antal studenter : Prerequisite knowledge equivalent to Epi I, Biostat I, and Biostat II or corresponding courses. EligibleUrval av studenter :

registered doctoral students will be prioritized according to 1) the relevance of the course content for their research, and 2) thestated motivation for attending the course. To be considered, please submit a completed application form and give all informationrequested, including a description of current research and motivation for attending, as well as an account of previous courses taken.

Course dates: 12, 14, 16, 19 and 21 November 2012. Exam 23 November 2012Ytterligare information :

Kursansvarig : Paul DickmanInstitutionen för medicinsk epidemiologi och [email protected]

Nobels väg 12A

112 44Stockholm


[email protected]

Title : Datainsamling och dataanalys II




Särskild behörighet : Efter kursen ska studenten kunna Diskutera hur forskningskunskap byggs upp och reflektera över detKursens lärandemål :

potentiella bidraget av det egna avhandlingsarbetet. Utveckla färdigheter i användandet av forskningssyntes som en vetenskapligprocess Förstå mångfalden i omfattning och metoder i forskningssyntes. Kritiskt bedöma procedurer i systematiskalitteraturöversikter

Tillhandahålla en introduktion i metoder för systematisk litteraturgenomgång. Utveckla ett protokoll för ochKursens innehåll : genomföra en systematisk litteraturgenomgång som fokuserar på hur en viktig komponent i den valda metoden har använts i tidigareforskning och hur den kommer att appliceras i studentens eget avhandlingsarbete. Kritiskt bedöma och diskutera svagheter ochstyrkor i protokoll och reviews.

Kursen är en distanskurs på deltid som omfattar 4 seminarier. Arbetsformer : Kursens lärandemål är inriktade på att hjälpa studenterna att teoretiskt och praktiskt applicera en teori eller en metodExamination :

som de använder i den egna avhandlingen. Därför är examinationsmetoden fokuserad på att stödja studenterna i att kritiskt granskaden valda metoden. Lärandemålen kommer att bedömas utifrån 1) En individuellt skriftlig plan eller protokoll för hur manimplementerar en systematisk litteraturgenomgång av hur en viktig metodkomponent har använts i tidigare forskning (2-3 sidor, 1,5radavständ, 12 punkter Times Roman). 2) En individuell systematisk litteratur genomgång av hur den viktiga komponenten haranvänts i nyligen publicerad forskning och en preliminär plan för hur den ska användas i studentens egna forskning. (8-12 sidor, 1,5radavstånd, 12 punkter Times Roman) 3) Aktivt deltagande i det sista seminariet, där en individuell uppgift presenteras ochdiskuteras. Fokus i den sista uppgiften kommer att vara på: 1) hur forskningsmetoder/teorier inkluderade i studentens egnaavhandlingsarbete har summerats i den individuellt genomförda forskningssyntesen 2) hur studenten, i en metoddiskussion, harkritiskt granskat procedurer i den egna systematiska genomgången.

Deltagandet i alla seminarier är obligatoriskt. Frånvaro från seminarium ska kompenseras med en skriftligObligatoriska moment : kritisk diskussion av temat för seminariet. Frånvaro från det sista seminariet ska kompenseras med en skriftlig kritisk diskussion avde andra studenternas skriftliga rapporter till det sista seminariet.

10 - 20Antal studenter : Prioritet ges till doktorander vid Nationella forskarskolan i vårdvetenskap. Urvalet baseras på motivering att gåUrval av studenter :

kursen. Denna kurs ger en introduktion till metoder som används vid systematiska översikter och fördjupadYtterligare information :

förståelse av ett teoretiskt eller metodproblem inom ramen för det egna avhandlingsarbetet. Kursen är delvis en distans kurs medflera seminarier 3-4 sep, 28-sep, 19-okt, 22-23 nov-2012.

Kursansvarig : Ann RudmanInstitutionen för klinisk [email protected]

Kontaktpersoner : -

Title : Study design in clinical research




Särskild behörighet : After completion of the course the students should be able to: 1) Independently plan and produce a studyKursens lärandemål :

protocol including a thorough methodological evaluation and choice of appropriate study design. 2) Critically reflect on otherstudents individual project work in a scientifically constructive way. 3) Interpret and critically evaluate scientific studies relevant to thecourse content.

The course is designed for PhD-students, in particular those who are at an early stage of their researchKursens innehåll : education, and those with an interest in conducting clinical research. The content of the course is as follows: 1) Basic terms inepidemiology and clinical study design, 2) Measures of disease occurrence and incidence, causality, 3) Observational studies-cohort and case-control studies, 4) Systematic and random errors, 5) Experimental studies, randomised clinical trials, 6) Quality oflife in clinical research, 7) Examination and course evaluation. Throughout the course, the students will work on an individual project(examination 1) for peer-review (examination 2). Further, students will critically review and discuss relevant scientific articles(examination 3).

Lectures, individual article review, group discussions and homework tasks will be used. The course focuses onArbetsformer : active learning, i.e. putting knowledge into practice and critically reflecting upon the knowledge, rather than memorising facts.Therefore, much of the focus of the course is on the individual project where students are required to develop a full study protocolincluding several important aspects covered in the lectures, article reviews and group discussions. Students will also peer-revieweachothers projects and this will form the basis for the final examination seminar.

To pass the course the student must actively participate in the course and pass the examinations: 1) IndividualExamination : project work: To develop a written comprehensive yet concise study protocol including several important aspects study design asdiscussed during the course; 2) Peer-review of other students projects followed by oral presentation of peer-reviewed projects ingroup discussions at the end of the course; 3) Critically review scientific articles relevant to the course content and participateactively in the group discussions.

Compulsory attendance includes the scheduled lectures and group discussions. Absence will need to beObligatoriska moment : replaced by individual assignments following discussion with the course co-ordinator, e.g. article reviews, with written or oralfollow-up.

12 - 16Antal studenter : Preference will be given to students early on in their PhD education, who have a clinical reseach focus, whereUrval av studenter :

the benefits of this course will be greatest. Date of registration as a PhD student will be used in the selection process. The course will run on Friday afternoons 14.00-16.15 at Norra Stationsgatan 67. Lecturers areYtterligare information :

researchers active in the Unit of Upper Gastrointestinal Research, directed by Professor Jesper Lagergren. The course is targeted atclinically active PhD students with an interest in clinical epidemiological research. The course focuses on registry-based researchand clinical trials. Scientific articles included focus on gastroenterological and surgical research but the main focus remains onadvantages and disadvantages of different study designs. Emphasis is on the application of knowledge gained during the course tothe students own research and planned studies.

Kursansvarig : Therese DjärvInstitutionen för molekylär medicin och kirurgi08 517 762 [email protected]

Kontaktpersoner : Anna WikmanInstitutionen för molekylär medicin och [email protected]

Norra Stationsgatan 67, vån 2

17176Stockholm

Margrete GellervikInstitutionen för molekylär medicin och kirurgi

[email protected]

Title : Metoder för kvalitativ innehållsanalys




Särskild behörighet : Efter genomgången kurs ska studenterna kunna att * kritiskt kommentera litteratur som förklarar utvecklingKursens lärandemål :

och metod av innehållsanalys. * välja en adekvat design för hans/hennes egna data. * förklara de olika delarna i analysen. * utföraanalysen. * kritiskt uvärdera svagheter och styrkor i analysmetoden.

Utveckling från en kvantitativ till en kvalitativ tradition av innehållsanalys Design och val av analys OlikaKursens innehåll : beståndsdelar i analysen Applicering och kritisk granskning

Kursen innehåller föreläsningar, seminarier och individuella uppgifter. Studenterna kommer att i projektarbetenArbetsformer : under hela kursen, med stöd från föreläsningar och individuella litteratur uppgifter, applicera innehållsanalys i sin egen forskning ochkritiskt reflektera på tillämpningen.

Studenterna kommer att i sina projektarbeten, i slutet av kursen, demonstrera kunskap och förståelse avExamination : innehållsanalys genom att lämna in en skriftlig rapport innehållande praktisering av analysen i förhållande till lärandemålen.

Kursen i sin helhet kräver aktivt deltagande av studenterna genom att medverka i olika typer avObligatoriska moment : lärandeformer.

10 - 20Antal studenter : Urval sker utifrån sökandes motivering att gå kursen.Urval av studenter :

Datum: 16-17 okt, 6-7 nov, 4-5 dec 2012 Adress till kurslokal: Alfred Nobels allé 23, campus Huddinge. Ytterligare information : Kursansvariga/kursledare är Professor Ella Danielson och Professor Kenneth Asplund från Mittuniversitetet.

Kursansvarig : Lena KochInstitutionen för neurobiologi, vårdvetenskap och samhä[email protected]

Kontaktpersoner : Anna SillenInstitutionen för neurobiologi, vårdvetenskap och samhälle08-524 868 [email protected]

Title : Improving drug use, especially antibiotics



ForskarnivåNivå : Department of Public Health SciencesKursansvarig institution :

Särskild behörighet : At the end of the module students will be able to: - appraise that medicinal drugs are one of the mainKursens lärandemål :

technologies used within the health care system and are also widely used for self-medication/home treatment. - analyse factorsaffecting drug use, both on macro- and micro-level and impact of Antimicrobial resistance to global health - evaluate differentmethods to increase the rational use of drugs, and in particular antibiotics

Contents: Sources to describe drug utilisation will be presented, together with possibilities and difficulties toKursens innehåll : collect appropriate data to show the level of drug use in a given population. Methods to estimate the level of self-medication andpeople¿s beliefs and behaviour will also be shown and discussed. The use of antibiotics will be used as an example as infectionsare one of the leading causes of morbidity worldwide. Furthermore, the use of antibiotics carries a special problem in that resistanceaffecting not only previously treated persons but also previously untreated persons may spread throughout the world. Antimicrobialresistance has been recognized as a threat to public health in all countries, by both WHO and EU. Examples of antibiotic use fromfrom countries of different income level and from different parts of the health system will be presented and discussed. In additionfactors affecting drug use, both on macro- and micro-level will be mapped out and discussed. The case of Europe will be presented,where it has been shown that antibiotic use is very different between neighbouring countries which indicates that other factorsbeside strict medical factors play an important role. Decisions to use drugs are taken in homes, pharmacies or other drug outlets,within primary health care as well as in hospitals. The concept of rational use of drugs includes correct use of good quality drugs atan affordable cost. Methods to increase the rational use of drugs, and in particular antibiotics, will be presented, including the role ofguidelines and various kinds of information or educational interventions directed to health care professionals, patients or the public.Ways of evaluating such interventions will be presented and discussed. The concept and content of National Drug Policies (NDP),which include elements such as legislation and drug quality assurance, development of guidelines and information material, andmonitoring of drug use, will be presented. The development and implementation of an NDP in Laos - a low income country - will beused as an example. One specific feature of the Lao NDP is that health systems research has been included as one element, andseveral projects concerning antibiotic use have been carried out.

1 week, fulltime. Learning activities include lectures, seminars and group work. Introduction to different searchArbetsformer : database.

A written individual assignment.Examination : It is compulsory to attend all the lectures. Absence will be compensate by extra individual assignmentObligatoriska moment :

provided by the course organizers. 5 - 25Antal studenter :

Selection will be done from 1)motivation 2)date as registered doctoral studentUrval av studenter : Ytterligare information :

Kursansvarig : Cecilia LundborgInstitutionen för folkhä[email protected]

Kontaktpersoner : Marie DokkenInstitutionen för folkhä[email protected]

Kersti RadmarkInstitutionen för folkhälsovetenskap

[email protected]

Title : Penotyping of genetically engineered mice



ForskarnivåNivå : Comparative medicineKursansvarig institution :

Kursspråket är engelska. The course is held in English.Särskild behörighet : Mål för kunskap och förståelse Efter kursen skall studenterna kunna redogöra för fenotypning av genetisktKursens lärandemål :

modifierade möss, beskriva systematisk och standardiserad fenotypsanalys av både transgena och knock in/out-möss. Studentenskall kunna redovisa för olika strategier för framställning av genetiskmodifierade möss, avelsproblematik, samt för tekniker ochmedel för undersökning av både enklare parametrar och mer specialiserade funktioner såsom beteende, kardiovaskulär fysiologi,neurobiologi och utvecklingsbiologi samt för djurskyddsaspekter. Mål för praktiska färdigheter Efter kursen skall studenten kunnaidentifiera målorgan för fenotypanalys Efter kursen skall studenten kunna genomföra praktiska undersökningar av genetisktmodifierade möss (obduktionsteknik). Efter kursen skall studenten kunna identifiera och särskilja mellan olika dataanalyser.

Denna kurs syftar till att visa hur genetiskt modifierade möss kan fenotypas på ett strategiskt sätt; genom urvalKursens innehåll : av relevanta "endpoints" och med användande av så få djur som möjligt, genom planering av olika testar som ska genomföras. Denger baskunskaper i systematisk fenotypsanalys av både transgena och knock-in/out möss. Kursen belyser relevanta delar avmusens biologi och fysiologi, strategier för framställning av genetiskmodifierade möss, avelsproblematik, samt redogör för teknikeroch medel för undersökning av både enklare parametrar och mer specialiserade funktioner såsom beteende, kardiovaskulärfysiologi, neurobiologi och utvecklingsbiologi. Kursen omfattar laborationer (obduktionsteknik), demonstrationer av olika moment.

Kursen omfattar föreläsningar, laborationer, demonstrationer och grupparbete med seminarieuppgifter. Kursen gårArbetsformer : heltid och dagtid. Kursspråket är engelska.

Lärandemål för kunskap och förståelse examineras genom redovisning av grupparbete. Examination : Grupparbeten och avslutande seminarier är obligatoriska. Bortvaro under kursen kompenseras enligtObligatoriska moment :

instruktioner från kursansvarig.15 - 25Antal studenter :

The applicants will be selected by their motivation letter and the relavence of this course to their projects.Urval av studenter : The course will take place at Karolinska Institutet, campus Solna. International lectures like Cory Brayton,Ytterligare information :

Associate Professor of Molecular and Comperative Pathobiology from Johns Hoplkins University and Björn Rozell, Professor atDepartment of Veternainry Disease Biology at University of Copenhagen, will be present. The strategic and endpoint selection dataanalysis consideration will be highlighted in this course occasion.

Kursansvarig : Raoul KuiperInstitutionen för laboratoriemedicin

[email protected]

Kontaktpersoner : Dude GigliottiKomparativ [email protected]

Berzelius väg 13

171 77STOCKHOLM

Title : Embryology I



ForskarnivåNivå : Department of Biosciences and NutritionKursansvarig institution :

Särskild behörighet : At the conclusion of this course students should be have a good understanding of: -- Why in vitro systemsKursens lärandemål :

are suboptimal in producing viable human embryos relative to development in vivo -- Main components of the culture system(culture media, tissue culture plastics, gases, incubators, workstations, laboratory environment, input materials) -- Physical-chemicalproperties of culture system (osmolarity and pH of culture media, temperature, light levels) and how they can be influenced --Constitution of tubal and uterine fluids and the evolution of culture media used in ART programmes as well as nutritionalrequirements of the various cell stages from gamete to blastocyst -- Tissue culture vessels -- Functional characteristics of differenttissue culture incubators -- Functional characteristics of different workstations for ART and their benefits -- The influence of thelaboratory and clinic environment on embryo culture -- The influence of the quality of the input material on outcomes in ART -- Themorphology of oocytes, zygotes and cleavage stage embryos as well as morulae and blastocysts -- Developmental milestones --Predictors of developmental potential -- Biochemical tests for predicting developmental potential -- The use of ultrasound to assessoocyte quality -- Student should be aware of the general aspects and implication of the stem cells research and the potentiality thatthis represent for clinical application -- Morphological aspects of the blastocysts for derivation of ICM and Derivation methods --Characterization of the embryonic stem cells and the importance of the pluripotency of these cells -- The different differentiationsassay on stem cells and what is ongoing in this field -- The immunorejection problem and the production of isogonics embryonicstem cells by somatic cell nuclei transfer or therapeutic clone (SCNT) -- Finally the students will improve their capacity to producecoherent, logical and concise explanations of data and concepts - both written and oral, through consideration of the coursematerial. -- Students will also develop their ability to criticize scientific literature related with ART and reproduction physiology in aconstructive and informed fashion

Divide in lectures and laboratory work Sperm theory (lecture) 1. Anatomy of the testis, sperm production andKursens innehåll : maturation, fertilization. 2. Cryopreservation of spermatozoa. 3. Sperm preparation for IVF and ICSI, criteria for ICSI. Embryology (Lecture) 1. Follicle growth and maturation, ovulation. 2. Cell biology and oocyte genetics. 3. Embryo development in-vitro,morphological evaluation of embryos. 4 Cryopreservation of embryos, theory and practice. 5. Embryonic stem cells. 6. Selection ofembryos for transfer and cryopreservation. Laboratory 1. How to work with sperm, oocytes and embryos. 2. Manipulation andtraining with mouse oocytes and mouse embryo handling. 3. Micromanipulation techniques, presentation. 4. Micromanipulationtraining. ICSI and embryo biopsy. Genetics (Lecture) 1. Genetic aspects of prenatal diagnostics and PGD. 2. Cloning techniques. Course test, evaluation, discussions and closing of course.

Course organization The course runs for one weeks with lectures before lunch and practical training in theArbetsformer : afternoons. José Inzunza and Julius Hreinsson are responsible for organizing the lectures and literature projects; and the practicaltraining of the participants and the laboratory work. Teaching laboratories at Södertörns Högskola will be used for the training inembryological techniques.

Writing individual.Examination : The laboratory parts are obligatory. Not attendance of the laboratory activity; student should present aObligatoriska moment :

literature work related with the subject of the missing activity.10 - 17Antal studenter :

The selection of the participants will be base on motivationUrval av studenter : This course will be held at KI south's Campus, Karolinska University Hospital, HuddingeYtterligare information :

Kursansvarig : Jose InzunzaInstitutionen för biovetenskaper och näringslära08-585 850 [email protected]

Hälsovägen 7, Novum

141 86Stockholm

Kontaktpersoner : -

Title : What is life? The future of biology.




Särskild behörighet : After the course students shall be able to discuss: 1. Theories about complexity of biological systems 2. HowKursens lärandemål :

biocomplexity can be studied. 3. What is the place of computational simulations in modern biology? How simulations can be done?What the predictive power is. How mathematics can be used in simulating biological phernomena. 4. How one understands theorganizational principles of biological systems. If self-organization is a field for study or just a trivial phenomenon. 5. Howevolotionary theory can be formalized into mathematical models. 6. If quantum mechanical theory can have a role in molecularbiology. 7. How genetic information can be converted to mechanical or electrical force in biological system. The students will alsoaquire an understanding of the conceptual and technical challenges in future biomedicine and advance your ability to ask scientificquestions and identify significant - and possible - areas for problem solving.

Inspired by the seminal book by Erwin Schrödinger What is life? published 60 years ago we will adress thisKursens innehåll : question again, in view of the impressive development since then. There are many new concepts to consider in the future of biology,such as the consequencies of the -omics era, complexity, computation and simulation, as well as the role of mathematicss andphysics in biological theory. The course will cover areas such as biocomplexity, quantum mechanical theory in biology, computationand simulation (in silico biology), organization of biological systems, causality in biology, how does chemistry become electric andmagnetic forces and evolutionary theory in the light of molecular biology. Leading scientists with an overview perspective will beinvited to discuss in the seminar form the challenges that meet us today in biology, as a result of the --omics era, the availability oflarge amounts of data as a result of high through-put techniques, and the possibilities provided by mathematics, simulation theoryand computational biology. Young scientists in this areas are also invited to lecture from their perspective. Invited experts will reviewthese areas in lectures. They will also meet the students for an additional two hours in a workshop discussion of basic concepts.

Two seminars+worskhop every month for five months, 2,5-3 hrs on each occassion. Every occasion consists of aArbetsformer : appr 1-2 hour seminar/lecture with the invited expert followed by a two hour open discussion, i.e 3-4 hours on each occassion. Foreach seminar the students will usually be given at least one article on the topic to read. Active participation in discussions in groupswith invited speaker of high international standards is a key element. You also receive DVD-recordings of all lectures for further selfstudies at home.

Continuous by workshop discussions. Written home-exam (essay). Examination : The seminars are compulsory. Absence can be compensated for after discussion with the course leader.Obligatoriska moment :

12 - 25Antal studenter : Based on motivation and need to take the course, on area of research, and if equal qualifications, on progressUrval av studenter :

of studies as measured by publications and time since registration.Two teaching occassions/month, 15.00 - 18.00 including discussion with students. The lectures andYtterligare information :

discussions are held at KI campus.

Kursansvarig : Ingemar ErnbergInstitutionen för mikrobiologi, tumör- och [email protected]

Box 280, Karolinska Institutet

17177Stockholm

Kontaktpersoner : Yvonne StrandbergInstitutionen för mikrobiologi, tumör- och cellbiologi

[email protected]

Title : Introduction to Stata for epidemiologists




Särskild behörighet : After successfully completing this course students should be able to: - use Stata to perform exploratory dataKursens lärandemål :

analysis, data cleaning, and prepare data for statistical analysis. - perform standard epidemiological analyses in Stata in an efficientand effective manner. - produce descriptive statistics and publication quality graphs using Stata.

The course is presented in two parts. The first part assumes no knowledge of epidemiology and biostatistics andKursens innehåll : introduces the Stata package and basic commands for data manipulation and presentation. The second part focuses on how Statacan be used to effectively manage and analyse epidemiological data. Therefore, basic knowledge of study design and measures ofexposure-disease associations is required. Part 1: (3 days) The course is designed to gently introduce students to the basics inStata. It will focus on the minimum number of commands that users should know in order to enter, manipulate, and present data.Specific topics include data-reporting, data-management, formatting and graphics. Part 2: (2 days) This part introduces students tobasic commands useful in epidemiology. Specific topics include tables and regression models for epidemiologist(cumulative-incidence, case-control and incidence rate data), assessment of confounding and interaction, and common graphicalrepresentations.

Lectures and computer exercises using Stata®.Arbetsformer : Written examination. Students who do not obtain a passing grade in the first examination will be offered a secondExamination :

chance to resubmit the examination within two months of the final day of the course. Students who do not obtain a passing grade atthe first two examinations will be given top priority for admission the next time the course is offered.

Written examinationObligatoriska moment : 12 - 25Antal studenter :

Eligible registered doctoral students will be prioritized according to 1) the relevance of the course content forUrval av studenter : their research, and 2) the stated motivation for attending the course. To be considered, please submit a completed application formand give all information requested, including a description of current research and motivation for attending, as well as an account ofprevious courses taken.

Course dates 17-18 September + 29-31 October 2012Ytterligare information :

Kursansvarig : Rino BelloccoInstitutionen för medicinsk epidemiologi och [email protected]

Brännkyrkagatan 45

11822Stockholm


[email protected]

Title : Pathology



ForskarnivåNivå : Department of Laboratory MedicineKursansvarig institution :

The level of the course is adjusted for students with a background in natural sciences but is open for all PhDSärskild behörighet : students. Students with a background in natural science are prioritized.

After the course the student has knowledge of basic pathological events and can analyse the connection ofKursens lärandemål : these events to the development of disease.

The course is divided into two parts. The first part illustrates cell injury, adaptation and inflammation.Kursens innehåll : Mechanisms of oxidative stress, cellular defence and ageing will be discussed as well as new methods in cellular and molecularpathology. During the second part of the course will focus on tumor development and malignancy. We will discuss how basicpathological responses to inflammation or injury might be the first steps on a multi-step path to malignancy.

This is a full time course with lectures, seminars, demonstrations and microscopy exercises.Arbetsformer : Presentation (individually) and discussion of group projects concerning different pathological events.Examination :

All demonstrations/microscopy/group work are compulsory. Absence must be compensated with a writtenObligatoriska moment : report.

20 - 30Antal studenter : The level of the course is adjusted for students with a background in natural sciences but is open for all PhDUrval av studenter :

students. Students with a background in natural science are prioritized. Selection criterion by registration date as a doctoral student. PLACE: Division of Pathology, Forskningsgatan, F58, Karolinska University Hospital at Huddinge. Ytterligare information :

Kursansvarig : Barbro Ek-RylanderInstitutionen för [email protected]

Kontaktpersoner : Arja KramsuInstitutionen för laboratoriemedicin

[email protected]

Barbro Ek-RylanderInstitutionen för [email protected]

Title : How to write a successful grant application



ForskarnivåNivå : Department of Women's and children's healthKursansvarig institution :

Särskild behörighet : After the course, the participants are expected to be able to write a successful grant application. In particularKursens lärandemål :

they should: - Be able to find suitable national and international funding opportunities - Know how to write a comprehensive andsuitable CV - Be able to write a high quality application to either a human ethics or an animal ethics committee - Be able to adjust tothe instructions of the granting agencies concerning the grants applied for - Be able to understand the priorities of the fundingagencies and when possible to adjust the application to their rationale - Be able to develop a well structured research plan withclear and testable hypotheses, clear aims (specific objectives and long-term goals), adequate background information from theliterature, appropriate, adequate and feasible methodology, and to be able to show that the research planned is significant forhuman health and society. - Be able to argue in a scientific manner for choice in methods for data collection and analysis. - Be ableto calculate costs and to set up a reasonable budget. - Understand how grant applications are reviewed and how qualities of anapplication may be scored using transparent and objective measures.

The course will contain lectures about the various aspects of finding funding opportunities and how to write aKursens innehåll : grant application, an assignment for each participant to work on her/his own application, group work on the reviewing processexchanging applications between the different groups formed by the course participants, and a final review meeting to decide onfunding. The lectures are focussed on the grant writing and reviewing processes, including applications to research ethicscommittees, how to write a CV and calculate budget, legal aspects and how to write contracts with funding agencies. There will be ahands-on workshop on finding funding opportunities.

The participants should come to the course with their own preliminary research application. The pedagogic frameArbetsformer : includes lectures (2 days), seminars (1 day), an assignment working on the participants' own applications (3 days), and group workreviewing applications with final presentation (1 day).

The examination consists of writing a short grant application (KI funding format), and participation in the process ofExamination : reviewing the applications of others. The professional attitude and scientific maturity of the participant in these processes will beevaluated.

The lectures, assignments and group work on reviewing applications are obligatory. Absence can beObligatoriska moment : compensated by writing another application and /or by reviewing other applications within 2 weeks after that the course is finished.

8 - 20Antal studenter : Selection will be according to time since registration to PhD studies and, if equal, needs as expressed inUrval av studenter :

written personal statement in the application. NOTE: THIS COURSE WILL BE HELD AT KI-PARTNER UNIVERSITY MAKERERE UNIVERSITY,Ytterligare information :

UGANDA The course has a hands on approach where PhD students will work with their own research grant applications and getdirect feed back on their work by the organizers. An absolute requirement is that all delegates should bring their own preliminaryapplication to work with. The course requries 7 days of full time engangement (excluded preparation). The exact time period will bedecided in collaboration with the Makerere University.

Kursansvarig : Olle SoderInstitutionen för kvinnors och barns hälsa

[email protected]

Kontaktpersoner : -

Title : Inherited cancer syndromes; Genes predisposing to malignant disease




Särskild behörighet : After the course the students will have received insight into all known cancer syndromes, what genes areKursens lärandemål :

involved, how they were found, what is known on mechanisms for carcinogenesis, what is the current clinical state of the art forthese syndromes conerning, genetic testing, counseling and prevention programs or available therapy for affected individuals. Thestudents will also know how the knowledge today was gained and also to present the front-line of the research in the field.

The course will present syndromes such as; breast/ovarian, colorectal cancer syndromes including FAP andKursens innehåll : HNPCC and other more rare syndroms involving breast- and colorectal cancer, tumor syndromes such as MEN1-2, NF1-2, DNS andinherited melanomas, Wilms tumor, Renal cancer including VHL, and the heritibility of most known cancers.

The course will hold lectures by clinicians working with affected patients in the clinic or in prevention programs,Arbetsformer : geneticists working with genetic testing, and or molecular biologists working with research in the field. The lectures arecomplemented by case-reports to be prepared by the students.

The case-reports will be presented on the last day and serve as examination procedure. In principle lectures will beExamination : given before lunch and afternoons are reserved for work in groups. Friday will present a summary of the contents and importance ofthe field and the examination procedure.Obligatoriska moment :

8 - 24Antal studenter : Selection will be based on 1) personal motivation and 2) date for admission to doctoral education.Urval av studenter :


Kursansvarig : Annika LindblomInstitutionen för molekylär medicin och [email protected]

Kontaktpersoner : -

Title : Forskningsetik



ForskarnivåNivå : Department for Clinical Science, Intervention and TechnologyKursansvarig institution :

Särskild behörighet : Efter kursen skall doktoranderna ha tillägnat sig en generell kunskap om etik i forskning, samt förmåga attKursens lärandemål :

självständigt kunna reflektera över och kritiskt diskutera etiska problem som omgärdar den egna forskningsuppgiften samt forskningi allmänhet.

En introduktion till etiken i samband med forskning och en orientering om dess tillämpning på problem inom detKursens innehåll : vetenskapliga området. Kursen behandlar bl.a. följande teman: etiska teorier, forskningsetik, forskaretik, innehåll i och värdet avregelverk, forskningsfusk och vetenskaplig oredlighet.

Föreläsningar (ca 6t), gruppövningar, seminarier(ca 8t) och muntlig och skriftlig presentationArbetsformer : Examination består av aktivt deltagande i seminarier, ett kortare skriftligt PM där ett tema inom ramen för kursenExamination :

behandlas. Detta PM presenteras också muntligt för de andra kursdeltagarna. Doktoranden förväntas relatera temat till det egnaavhandlingsarbetet. Godkänd kurs innebär aktivt deltagande i seminarier och godkänd muntlig och skriftlig presentation avexaminationsuppgiften.

Obligatoriskt är att delta vid introduktionstillfället och vid seminarier. Vid frånvaro kan detta kompenserasObligatoriska moment : med utökat PM skrivande och muntlig presentation för kursen eller kursgivare.

15 - 20Antal studenter : Urval för denna allmänvetenskapliga baskurs görs genom (1) din rangordning av kursen och (2) datum förUrval av studenter :

antagning till forskarutbildning vid KI. Se till att du har fyllt i korrekt datum för antagning i din personliga profil samt att du harrangordnat sökta baskurser.

Kursen ges en eftermiddag/vecka (tisdag). Kursen hålls på Anestesi- och intensivvårdskliniken, KarolinskaYtterligare information : Universitetssjukhuset, Huddinge.

Kursansvarig : Sigridur KalmanInstitutionen för klinisk vetenskap, intervention och [email protected]

Kontaktpersoner : Monika ArmuandInstitutionen för klinisk vetenskap, intervention och [email protected]

Title : To communicate science in different contexts




Särskild behörighet : After the course the student is expected to be able to: 1. Orally present own research adapted to differentKursens lärandemål :

target groups. 2. Reflect on presentation skills and ability to adapt to different target groups.During the course each participant will be given the opportunity to develop practical and theoretical knowledgeKursens innehåll :

in: -- Communication, perception and learning -- Presentation techniques -- Rhetoric -- Use of different media (such as Posters,Overhead-projector, PowerPoint, Whiteboard) Each course participant will perform three oral presentations and receive feedback oncontent, presentation skills and adaptation towards target group.

The course design is based on reflective practice and includes self-directed learning, lectures and literature seminarArbetsformer : to process theoretical knowledge, and practical training in presentation skills.

The assessment consists of two different tasks: 1. Reflective statement based in experience, feedback andExamination : research/literature within communication and learning. 1. Oral presentation in a popular scientific context supported by PowerPointor similar. To pass the course the participant needs to show evidence that they reached the learning outcomes by fulfillment of theassessment criteria.

Compulsory sessions are: 1. Oral presentation in a popular science context (video recorded) 2. OralObligatoriska moment : presentation in a scientific context and observe and give feedback to an oral presentation made by a peer. Absence from thecompulsory sessions or assessment seminar can be compensated through supplementary activity.


(2) your admission date to doctoral education at Karolinska Institutet. Please make sure that you have put in the correct registrationdate for doctoral education at KI in your personal profile and that you have ranked the courses you have applied for.

The course is a two week course which requires time for independent work outside of scheduled classYtterligare information : time. Scheduled class room sessions are on the following dates: 6-7 sept, 20-21 sept and 11-12 oct. The course is given inENGLISH. This course is also available in swedish, see course catalogue.

Kursansvarig : Samuel EdelbringInstitutionen för lärande, informatik, management och etik

[email protected]

Kontaktpersoner : Ingrid SmedbergInstitutionen för lärande, informatik, management och etik08-524 837 [email protected]

Title : Att kommunicera vetenskap i olika sammanhang




Särskild behörighet : Vid slutet av kursen förväntas studenterna kunna: 1. Muntligt presentera egen forskning anpassad till olikaKursens lärandemål :

målgrupper. 2. Reflektera över färdigheter i presentationsteknik och förmågan att anpassa budskapet till olika målgrupper. Under kursen ges deltagarna möjlighet att utveckla praktiska och teoretiska kunskaper om: -Kommunikation,Kursens innehåll :

perception och lärande -Presentationteknik -Retorik -Användning av hjälpmedel såsom poster, overhead, PowerPoint, whiteboard Varje kursdeltagare genomför tre muntliga presentationer och får återkoppling på innehåll, presentationsteknik och anpassning tillmålgrupp.

Kursdesignen är baserad på reflekterande praktik och inkluderar självstudier, föreläsningar och litteraturseminariumArbetsformer : för att bearbeta det teoretiska innehållet, samt praktiska övningar för att träna färdigheter i presentationsteknik.

Examinationen består av två uppgifter: 1. En skriftlig reflektion baserad på erfarenheter av och återkoppling påExamination : presentation samt forskning/ litteratur inom kommunikation och lärande. 2. Muntlig presentation i ett populärvetenskapligtsammanhang med stöd av PowerPoint eller motsvarande. För att bli godkänd på kursen krävs att deltagaren visar att lärandemålenhar nåtts genom att uppfylla bedömningskriterierna.

Obligatoriska moment är: 1. Muntlig presentation i ett populärvetenskapligt sammanhang (spelas in påObligatoriska moment : video). 2. Genomföra en muntlig presentation i ett vetenskapligt sammanhang samt observera och ge återkoppling på enkurskamrats presentation. Frånvaro från obligatoriska moment eller examinerande moment kan kompenseras medersättningsuppgifter eller motsvarande.

20 - 40Antal studenter : Urval för denna allmänvetenskapliga baskurs görs genom (1) din rangordning av kursen och (2) datum förUrval av studenter :

antagning till forskarutbildning vid KI. Se till att du har fyllt i korrekt datum för antagning i din personliga profil samt att du harrangordnat sökta baskurser.

Kursen motsvarar två veckors studier och kräver eget arbete utanför schemalagd tid. Följande datum ärYtterligare information : schemalagda: 20-21 nov, 4-5 dec och 18-19 dec. KURSEN HÅLLS PÅ SVENSKA / COURSE IS GIVEN IN SWEDISH.

Kursansvarig : Samuel EdelbringInstitutionen för lärande, informatik, management och etik

[email protected]


Title : Cardiovascular Epidemiology




Särskild behörighet : Students having successfully completed the course are expected to recognize different risk factors or riskKursens lärandemål :

indicators for cardiovascular disease and different cardiovascular phenotypes. Students should be able to discuss the study designsmost commonly used within cardiovascular epidemiology. In addition, students should be able to interpret study results critically.

Overview and discussion of risk factors/risk indicators - environmental, genetic and biochemical. Discussion ofKursens innehåll : theories and concepts related to common epidemiological and genetic study designs - cohort, case-control, and genetic associationstudies.

Lectures (cathedral) Group work, to consolidate and reflect upon concepts introduced during the course. Seminars. Arbetsformer : Learning outcomes will be assessed using 1) a short individual written examination covering different researchExamination :

methods used within cardiovascular epidemiology, and 2) a written group examination.Participation in group work and article seminars is mandatory. Compensation through an individual writtenObligatoriska moment :

assignment.12 - 25Antal studenter :

Eligible registered doctoral students will be prioritized according to 1) the relevance of the course content forUrval av studenter : their research, and 2) the stated motivation for attending the course. To be considered, please submit a completed application formand give all information requested, including a description of current research and motivation for attending, as well as an account ofprevious courses taken.Ytterligare information :

Kursansvarig : Karin LeanderInstitutet för miljö[email protected]

Box 210 (Nobels väg 13), KI

171 77Stockholm

Kontaktpersoner : Ann HellstromInstitutionen för medicin, Solna

[email protected]

Karin LeanderInstitutet för miljö[email protected]

Box 210 (Nobels väg 13), KI

171 77Stockholm

Title : Malaria




Särskild behörighet : At the end of the module students will be able to: - discuss current issues in malaria research, preventionKursens lärandemål :

and control in low and middle income countries - analyse broader context of malaria prevention and control interventions - explainthe importance of the recent pathogenesis of malaria - understand the management of severe and uncomplicated malaria

Malaria epidemiology, life cycle, morphology, pathogenesis, clinical aspects, diagnostic methods. Principles forKursens innehåll : therapy and prophylaxis, pharmacology and resistance to antimalarial drugs. Immunology, genetics and vaccines. Entomology andvector control. Public health and socio-economic aspects. New control policies and research strategies.

The course will consist of lectures, seminars and practical sessionsArbetsformer : Written examination.Examination :

It is compulsory to attend all the lectures. The practical sessions attendance is not compulsory for studentsObligatoriska moment : with previous knowledge on the specific skills. It will be possible to compensate absence by completing individual assignmentsprovided by the course organizer.

12 - 35Antal studenter : Priority will be given to doctoral students with projects in Infectious Diseases and Global Health.Urval av studenter :


Kursansvarig : Anna FarnertInstitutionen för medicin, Solna

[email protected]

Infektionsenheten

17176Stockholm

Kontaktpersoner : Anne RasikariInstitutionen för medicin, Solna08-517 718 [email protected]

B3:03

Title : Cellular and molecular infection biology




Särskild behörighet : After the course the students will have an overview of the various aspects of microbial infections withKursens lärandemål :

bacteria, viruses and parasites. The students will have knowledge on the level of current understanding of the cellular and molecularmechanisms used by pathogenic microbes, since the course will provide "state-of-the-art-level" presentations in selected aspects ofa host-pathogen interaction. The students will be able to give examples of interdisciplinary studies in the research field ofmicrobe-host interactions, many lectures focus on interdisciplinary themes such as microbe-cell interactions, microbial manipulationof host inflammatory responses, pathogen transmission and novel techniques to study microbe-host interactions. Analytical andcritical thinking will be encouraged by the course design. The students will also have an improved capability for scientificdiscussions, since the course provides the possibility to interactive discussions with invited teachers, who will attend the studentpresentation. After the course the students will have a more holistic picture of infection biology, and hopefully they will beencouraged to apply such new information for the benefit of their further graduate training and even get significant input for their ownresearch.

Microbial pathogenesis, the interplay between microbes and various host responses and transmission ofKursens innehåll : pathogens

The course consists of lectures by in-house and invited speakers on various topics in the discipline of cellular andArbetsformer : molecular infection biology. Presentations will cover basic aspects of the research topic that will provide the students with afoundation in the subject. In addition, the more advanced part of the lecture will present state-of-the-art research. Groups of studentswill prepare a seminar and another group will act as ¿opponents¿ to critically analyse the presentations. The students willsubsequently participate in interactive student-driven discussions which includes the invited teacher.

The students will be assigned a series questions based on topics that have been discussed during the course in aExamination : written examination.

The compulsory parts of the course are preparation and attendance of the lectures and the student groupObligatoriska moment : presentations. If the students cannot attend a lecture they should write a summary based on the course literature for this lecture.There will be a written examination at the end where the students should discuss a given problem within microbial pathogenesis andmicrobe-host interactions.

15 - 40Antal studenter : The selection of participants will be after previous applications for the course, relation to doctoral topic and Urval av studenter :

time of doctoral studies.The course will be given for two weeks between the 19th and the 30th of November 2012 at the Ytterligare information :

Department of Microbiology, Tumor and Cell Biology. A preparatory meeting for information and to select topics for student seminarswill be held in due time before course start.

Kursansvarig : Ute RömlingInstitutionen för mikrobiologi, tumör- och [email protected]

Kontaktpersoner : Gerald McInerneyInstitutionen för mikrobiologi, tumör- och cellbiologi08 [email protected]

Nobels väg 16

17177Stockholm

Title : Course in endocrinology and metabolism




Särskild behörighet : The overall aim of the course is to give students an overview on current advances/knowledge concerningKursens lärandemål :

mechanisms for metabolic diseases with focus on diabetes and obesity. After the course the students will: Be able to understandknown mechanism for metabolic diseases (with focus on diabetes and obesity), if and how they could be prevented Be able toindependently compile knowledge within selected area (metabolic diseases, endocrinology) Be able to critically review receivedknowledge within the above mentioned area. Be able to work in a group and give constructive feedback to other students. Be ableto give a short oral presentation of scientific article/articles within a specific research field.

During the course the students will receive current knowledge on understanding mechanisms for metabolicKursens innehåll : diseases, mainly diabetes and obesity.

Lectures, discussions, group work, oral and written presentationArbetsformer : Write a short summary of scientific article/articles within a specific research field and present it orally. Examination :

The presence on lectures and examination is mandatory. Missing lectures must be compensated byObligatoriska moment : written resume.

15 - 35Antal studenter : If the number of applicants exceeds the number of available places, applicants will be chosen based on theUrval av studenter :

written motivation.The course will take place at Karolinska Institutet, Campus Solna for one week, full time. Ytterligare information :

Kursansvarig : Dana GaluskaInstitutionen för Fysiologi och [email protected]

Kontaktpersoner : Marie BjörnholmInstitutionen för molekylär medicin och [email protected]

Title : Developmental biology for regenerative medicine




Särskild behörighet : After the course, the students should know the basics of stem cell biology and the medical use of cellKursens lärandemål :

therapy. The students should be able to describe and understand the theoretical basis for key technologies utilized in stem cellresearch.

The course covers key concepts in translational research from the laboratory to the clinic, including anKursens innehåll : advanced review of descriptive and molecular developmental biology.

The pedagogic learning activities on the course consist of cathedral lectures, group discussions and studentArbetsformer : presentations.

The students are examinated individually with a quiz or a written essay. The final course examination is a projectExamination : presentation in groups.

Participation in the group discussions and student presentations is mandatory. Compensation through anObligatoriska moment : individual written assignment.

5 - 8Antal studenter : The selection is based on a comprehensive assessment based on the relevance of the course for the doctoralUrval av studenter :

research project and the personal motivation written by the applicant.The course is organized by the Research School of the Linné Center DBRM (Developmental Biology forYtterligare information :

Regenerative Medicine). More course information can be found at the Research School web pages at www.dbrm.se. The course isfull time, given in English and the course venue is the seminar room A216 at CMB, Berzeliusv 35.


[email protected]

Kontaktpersoner : -

Title : Introduction in Medical Education Research




Särskild behörighet : After the course the student is expected to be able to 1. Reason and argue about the significance of theKursens lärandemål :

Medical Education research field in relation to the Higher Educational field. 2. Identify, analyze and describe different kinds of issuesand phenomena that are researched in Medical Education. 3. Reflect on and express similarities and differences of differentresearch approaches and methods used in Medical Education Research.

The course content include studies of the Medical Education field especially: * Significance of professionalKursens innehåll : educational programmes, disciplines and subjects in the medical and health care field * Researching different areas within medicaleducation - student learning, teaching, course/curriculum design, assessment and evaluation * Researching learning and teaching inclinical eduaction and the health care field - supervision, professional development and patient education * Qualitative andquantitative approaches and methods in Medical education research

The course design is based on the students active participation in his/her own learning process. Self directedArbetsformer : learning activities will be stimulated and processed by assignments, lectures, seminars, group work and discussion boards inPingpong.

The assessment consists of two main parts: * A reflective paper based on an analysis of a self chosen article withinExamination : Medical Education. The analysis and reflection is expected to relate to the learning outcomes. * Written and oral self and peerassessment related to assignmemts, seminars and group work. The assessment criteria (correspondence, coherence, capacity andcritical appraisal) must be fullfilled to pass the course.

Assignments, seminars and group activities. Absence from seminars and group activities can beObligatoriska moment : compensated by self studies and written statements.

10 - 20Antal studenter : 1. Doctoral students within Medical Education Research 2. Date of registration Urval av studenter :

Course days campus: 3-4 Okt, 16 Okt, 7 Nov, 22 Nov, 5-6 December Kurslokal: Berzelius väg 3, LIME,Ytterligare information : plan 4 Researchers in Medical Education at Centre for Medical Education, CME at KI will run the course and researchers from otherinternational Centres in Medical Education are invited as quest lectures.

Kursansvarig : Charlotte SilénInstitutionen för lärande, informatik, management och [email protected]


Title : Social skills: Presentation techniques, cooperation and relationships




Särskild behörighet : After attending this cours the PhD student will: - have tools for presenting their research in a successfulKursens lärandemål :

manner - have gained an understanding of how an audience is influenced by for example our body language - have learned to makethe best out of him/herself as a speaker - have a deeper understanding of mechanisms promoting and reducing cooperationbetween individuals and within a group - understand why cooperation might be difficult and in which way humans are unique in theway we cooperate - understand more about how to apply the mechanisms of cooperation in a group

Presentation technique: Lectures on themes like body language and status. Practical sessions on bodyKursens innehåll : language, presentation, improvisation, and different techniques to make your presentation more interesting and help you delieveryour message. Everyone can improve their skills in expressing themselves in an inspiring, secure, and enthusiastic way, no matter ifthe purpose is to give a lecture in front of a big audience or to express your opinion within a group. With the help of someimprovisation exercises you will learn how to use your personal strengths in order to increase your self esteem. Cooperation andrelationships: Theory, economic games, discussions, and assignments will be mixed. You learn about the mechanisms anddynamics of cooperation; how you can influence cooperation in a group and how this can be translated to your every day work as amember of a research group. By understanding and applying the mechanisms which influence how prone we are to cooperate wewill become more successful in our relationships with other people, both professionally and in private life.

Group assignments, lectures, economic games, discussions, supervision in group, oral presentations, individualArbetsformer : assignments.

Oral presentation and individual assignments. Examination : Compulsory parts: 1. individual, written analysis of a cooperation problem 2. group assignment andObligatoriska moment :

presentation where the mechanisms behind cooperation are discussed Written assignments as compensation for missedcompulsory parts.

10 - 20Antal studenter : 1) personal motivation 2) planned date for dissertation or half time seminar - priority is given to phd studentsUrval av studenter :

who have passed half time or are about to do their dissertationWelcome to apply for the course on Social Skills! We would like to inform you that we focus a lot on the Ytterligare information :

personal motivation in the application when deciding who will participate in the course. Therefore we would like to ask you to spendsome extra time on writing something about why you are applying for this course, in which way it would be of value for yourself andyour doctoral studies, what you expect of the course, why you think cooperation is important in research and also something aboutyourself and your doctoral studies. This course is in English, including all lectures and assignments. (The course will also be given inSwedish.) Lecturers are Sofia Czinkoczky, Carl-Adam Wachtmeister, Andreas Löhmer and Anna Hildenbrand Wachtmeister: SofiaCzinkoczky is an actress with many years of experience in giving courses in improvisational theatre and presentation technique.Sofia has been head of Stockholms Improvisationsteater. Since 1999 she has been working in the field of education and givingcourses in communication, improvisation, and creativity for companies. Her passion is to make people dare using their innatecreativity, which also show in her courses on presentation technique. Carl-Adam Wachtmeister did his PhD on behavioural biologyand has about 15 years of research and teaching experience in the field of human and animal behaviour. Today he is a seniorconsultant, with assignments in both universities and companies. In his work Carl-Adam is focusing on cooperation and culturalchange. Andreas Löhmer did his PhD at the University Konstanz, Germany and now he works as vice director at the ExecutiveSchool of Management, Technology and Law of the University of St. Gallen, where he is responsible for Custom Programs. Beforejoining ES-HSG Mr. Löhmer managed the Business Faculty of one of the largest insurance company¿s Corporate University inParis. Furthermore he was responsible for its Top Executive Leadership Program for several years. Prior to his activity in France Mr.Löhmer worked as Associate Partner on numerous international assignments with a Swiss consulting company in Sankt Gallen. Mr.Löhmer has established an expertise (consultant, trainer) in topics such as leadership, effective management, rethorics, change andorganisation development as well as specific questions on strategy development. Mr. Löhmer published several articles in journalsand contributed in books. Anna Hildenbrand Wachtmeister did her PhD at Karolinska Institutet and is also a licenced ICF Executiveand Leadership Coach, working as a senior consultant in the field of business coaching, leadership development and cooperationwithin organizations. The course will be conducted at Karolinska Institutet and Hospital in Solna. Please ADDRESS ALLQUESTIONS TO Anna Hildenbrand Wachtmeister, [email protected] cell phone: 070-789 06 07

Kursansvarig : Kristina GemzellInstitutionen för kvinnors och barns hä[email protected]

Kontaktpersoner : Anna HildenbrandInstitutionen för kvinnors och barns hälsa0707890607

[email protected]

Title : Social kompetens: Presentationsteknik, samarbete och relationsbyggande




Inga krav på förkunskaperSärskild behörighet : Efter genomgången kurs ska doktoranden ha: - verktyg för att på ett framgångsrikt sätt presentera sinaKursens lärandemål :

forskningsresultat - förståelse för hur vi påverkar en publik genom exempelvis vårt kroppsspråk - lärt sig ta till vara på sina styrkorsom talare - kunskap om hur man disponerar och strukturerar ett budskap respektive en presentation - en djupare förståelse för demekanismer som främjar respektive bryter ner samarbetet mellan individer eller inom en grupp - förståelse för varför samarbete ärsvårt, på vilket sätt människan är unik i djurvärlden i sitt sätt att samarbeta - en ökad förståelse för hur vi kan tillämpasamarbetsmekanismerna i en grupp

Presentationsteknik: Teoretiska övningar omfattar bland annat strukturering av ett budskap och en presentation,Kursens innehåll : vilka media vi har att tillgå för att nå ut till en publik samt vikten av kroppspråket. De praktiska momenten omfattar egnapresentationer. Alla kan träna upp sin förmåga att uttrycka sig engagerande, inspirerande och säkert, vare sig det handlar om attföreläsa inför en stor publik eller att framföra åsikter i en grupp. Genom improvisationsövningar lär du dig använda dina personligastyrkor medvetet för att bli mer självsäker, närvarande och uttrycksfull. Samarbete och relationsbyggande: Teori varvas medgruppövningar och vi går igenom samarbetets mekanismer och dynamik, hur vi kan påverka samarbetet i en grupp och hur detta serut i praktiken i er vardag som medlem i en forskargrupp. Genom att förstå och tillämpa de mekanismer som påverkar vårbenägenhet att samarbeta kommer vi att bli mer framgångsrika i våra relationer till andra människor, vare sig det gäller enprofessionell relation eller privat.

Gruppövningar, föreläsningar, handledning i grupp, muntliga presentationer, enskilt arbete.Arbetsformer : Presentationer och gruppövningar.Examination :

Obligatoriska moment: 1. analys av ett samarbetsproblem 2. gruppanalys och presentation avObligatoriska moment : mekanismerna bakom samarbete. Kompensation för eventuell frånvaro: skriftlig inlämningsuppgift motsvarande de missadekurstillfällena.

10 - 20Antal studenter : Urvalet sker på en sammanvägning av a) motiveringen till varför studenten vill genomgå kursen och b) hittills Urval av studenter :

avlagd forskarutbildning, dvs halvtidskontroll, tid till planerad disputation, registeringsdatum.Välkommen att söka kursen i Social kompetens! Vi vill informera om att stor vikt läggs vid den personligaYtterligare information :

motiveringen i ansökan när kursplatserna fördelas och därför be dig lägga ner lite extra tid på att skriva några rader PÅ SVENSKAom varför den här kursen vore av betydelse för dig och dina doktorandstudier, vad du förväntar dig få ut av den, varför du tycker attsamarbete är viktigt för forskningen och dessutom något om dig själv och din forskning. Denna kurs ges på svenska och det är avavgörande betydelse att du behärskar språket i tal och skrift. (Kursen ges även på engelska.) Föreläsare på kursen är SofiaCzinkoczky, Carl-Adam Wachtmeister, Andreas Löhmer och Anna Hildenbrand Wachtmeister: Sofia Czinkoczky är skådespelaremed stor erfarenhet av kurser i improvisationsteater och presentationsteknik. Sofia har tidigare arbetat som konstnärlig ledare påStockholms Improvisationsteater. Sedan 1999 arbetar hon med utbildning och ger kurser i kommunikation, improvisation ochkreativitet för företag. Sofia brinner för att få människor att våga använda mer av sin inneboende kreativitet, vilket tydligt märks ihennes kurser i presentationsteknik. Carl-Adam Wachtmeister är disputerad beteendebiolog med närmare 15 års erfarenhet avforskning och undervisning om beteende hos människor och djur. Idag arbetar han som konsult och verkar både inomuniversitetsvärlden och företagsvärlden, med regelbundna uppdrag bl.a. för Karolinska institutet, Göteborgs universitet ochStockholms universitet. Carl-Adam har specialiserat sig på samarbete och kulturell förändring. Andreas Löhmer är disputerad ocharbetar som vice VD för Executive School of Management, Technology and Law of the University of St. Gallen, Schweiz. Där arbetarhan huvudsakligen med skräddarsydda utbildningsprogram. Andreas Löhmer har en gedigen bakgrund, bland annat som chef förutbildningsinstitutet vid ett av världens största försäkringsbolag i Frankrike och som associate partner vid talrika internationellauppdrag. Andreas Löhmer undervisar huvudsakligen inom ledarskap, effektivt management, förändringsarbete, retorik,organisationsutveckling och strategi. Han har också skrivit en rad artiklar och varit medförfattare i ett antal böcker. An entrepreneurhimself Mr. Löhmer established an expertise (consultant, trainer) in topics such as leadership, effective management, change andorganisation development as well as specific questions on strategy development. Mr. Löhmer published several articles in journalsand contributed in books. Anna Hildenbrand Wachtmeister är disputerad vid Karolinska Institutet och certifierad ICC-coach. Hondriver idag eget företag med verksamhetsområdet förändring, samarbete och utveckling inom olika brancher och har många årserfarenhet som egen företagare och även som föreläsare. Undervisningen sker på Karolinska sjukhuset i Solna och i Gamla stan.Varmt välkommen! SAMTLIGA FRÅGOR skickas till Anna Hildenbrand Wachtmeister [email protected] mobil:070-7890607


Kontaktpersoner : Anna Hildenbrand

Institutionen för kvinnors och barns hä[email protected]

Title : Basic Laboratory Safety




Experience of laboratory workSärskild behörighet : After successfully completing this course you as a student should be able to evaluate the risks associatedKursens lärandemål :

with experiments in the laboratory. The hazards could originate from chemicals, microbiological agents and blood/tissue. You shouldalso be able to identify the needs for personal protective equipment, routines for waste management and transport. In addition, youshould be familiar with the regulatory framework that governs these topics, the basic needs of a safe laboratory, and be able toidentify the chain of responsibilities.

The course aims at giving theoretical and practical aspects of laboratory safety.Kursens innehåll : The information will be given as lectures, group discussions, practical session and computer sessions during a totalArbetsformer :

of five days. The examination is based on individual written examination and a risk assessment.Examination :

Presence during all the scheduled activities are compulsory. Students can compensate for absenceObligatoriska moment : through individual assignments.


(2) your admission date to doctoral education at Karolinska Institutet. Please make sure that you have put in the correct registrationdate for doctoral education at KI in your personal profile and that you have ranked the courses you have applied for. Ytterligare information :

Kursansvarig : Roland MöllbyInstitutionen för mikrobiologi, tumör- och [email protected]

Kontaktpersoner : Jenny KarlssonUniversitetsförvaltningen08 524 872 [email protected]

Title : Non-coding RNAs, microRNAs in human diseases




Särskild behörighet : After the completed course the student students should be able to - explain the term microRNA, differencesKursens lärandemål :

and similarities between them and ordinary genes and siRNAs, - summarize the relevance of microRNAs in development anddisease, - relate the microRNAs to real word situation such as basic biological functions and major human diseases (i.e.: cancer). -discuss the role of small RNAs in the diagnosis and treatment of disease - demonstrate a scientific way of thinking about thepossible roles of microRNAs in their own research field. - critically think about advantages and disadvantages of methods used inmicroRNA research - use the most commonly used computational algorithms to predict microRNA targets, microRNAs targeting theirgene of interest, miroRNAs which are co-expressed with targets in tissues, predict microRNA-target gene networks After completingthe laboratory work, the students should be able to measure microRNA expression by means of - quantitative real-time PCR and -Northern-blot methods.

The course presents recent advances about a recently discovered novel class of genes, microRNAs, in humanKursens innehåll : diseases and cellular processes. In the first half of the course, lectures will be given by microRNA-researchers, who will provide acomprehensive overview. Lectures will be followed by detailed analysis and discussion with the participants. Students will be askedto present original papers or reviews on the topic, which will be handed out in advance. Students will learn how to predict targets ofa microRNA using different computational algorithms. Student groups will get the task of preparing a list of predited targets for theselected microRNA, do literature search and then summarize and present their hypotheses about the function of the microRNA theyget for this task as a short presentation. In the second half of the course, 2 days of laboratory work will be dedicated to learning howto analyze microRNA levels in RNA samples using quantitative real-time PCRs and Northern blot analysis and half a day forbioinformatics training in a computer room, where different various programs and algorithms will be used. Laboratory work will bededicated to learn how to analyze microRNA levels in RNA samples using quantitative real-time PCRs and Northern blot analysis.

Structured lectures and seminars on which the course participants are expected to work in discussion groups,Arbetsformer : problem-based learning and student presentations. 3 days laboratory work (we-lab + bioinformatics lab).

At the end of the course, students are examined in a final seminar based on presentation of group projects.Examination : Participation in and preparation for the group discussions and student presentations is mandatory.Obligatoriska moment :

Absence from will be compensated according to the instructions of the course director.10 - 15Antal studenter :

Selection of participants will be based on motivation for attending the course.Urval av studenter : Ytterligare information :

Kursansvarig : Andor PivarcsiInstitutionen för medicin, Solna

[email protected]

Kontaktpersoner : Inger WestinInstitutionen för cell- och molekylä[email protected]

Title : Live cell imaging




noneSärskild behörighet : After passing the completed course, the students will be familiar with the basic principles of fluorescenceKursens lärandemål :

microscopy and diverse live cell imaging techniques. They will be competent in independently designing and performing live cellimaging experiments and understand the possibilities/limitations of different live cell imaging techniques.

Basic principles of fluorescence microscopy and live cell imaging. Confocal Laser Scanning Microscopy Kursens innehåll : Deconvolution fluorescence Microscopy Basic principles of advanced fluorescence techniques. Design and perform live cell imagingexperiments. Data analysis and presentation.

The pedagogic learning activities on the course consist of lectures, research seminars, laboratory work (imaging),Arbetsformer : group discussions, data processing and student presentations.

The students are examinated through 1) an individually written assigment (case study), 2) a practical session and 3)Examination : a poster presentation.

All activities (lectures, research seminars, laboratory work, group discussions, data processing and studentObligatoriska moment : presentations) are compulsory. If students are unable to attend they have to discuss with course organizer how this can becompensated. Compensation of the laboratory work is not possible.

8 - 16Antal studenter : The selection is based on a comprehensive assessment based on the relevance of the course content for theirUrval av studenter :

PhD project the personal motivation letter to attend the course.The course will cover theoretical and practical work on different fluorescence microscopes (confocal laserYtterligare information :

scanning microscopy, deconvolution fluorescence microscopy, grid confocal microscope) focused on live cell imaging with theapplication of various fluorescence techniques (Fluorescence Restoration After Photobleaching, Fluorescence Loss Induced byPhotobleaching, photoactivation, fluorescence resonance energy transfer). The course includes introduction lectures, 2-3 researchseminars from international speakers, and hands-on sessions at different fluorescence microscopes.The students will be trained toapply diverse live cell imaging techniques in real life scientific problems, and will be competent to operate different fluorescentmicroscopes and perform live cell imaging experiments.

Kursansvarig : Florian SalomonsInstitutionen för cell- och molekylä[email protected]


Title : Neuroanatomy from development to adulthood




Särskild behörighet : 1) To understand the neuroanatomical base of unique feature of human brain development: specificKursens lärandemål :

lamination, cellular elements and timing of developmental events. 2) To identify and understand the macroanatomical andmicroscopical structures of adult human brain and their interconnections. 3) To understand the evolution of the human brain bycomparisons with brains from other species.

A) Development of human brain from fetal to newborn and perinatal period, with specific emphasis towards aKursens innehåll : transient fetal lamination pattern, migration and differentiation of the neurons, fetal neuronal circuits and plasticity in the fetal brain.The normal brain tissue will be demonstrated on microscope and on MRI images. B) Development and distribution of theconnections in the brain, with specific emphasis on the frontal cortex circuits in the normal development and adulthood. The tracingmethod will be discussed and samples will be presented on microscopy. C) Main histological features of adult human brain,cytoarchitectonic differences between different regions and importants of thalamic and basal ganglia projection to the cortex. Aspecific emphasis to comparative anatomy of the cortex between different species: rats, dolphins, camel, macaqua, orangutan, willbe presented on stained sections.

Lectures, discussion, multiple and single microscopy, practical demonstration. Arbetsformer : Electronic submission of answers to short questions, identification of pictures and an essay in the subject will beExamination :

required for passing the course. The entire course is compulsory. In case of absence, a possible compensation will be discussed with theObligatoriska moment :

course leader.10 - 12Antal studenter :

Priority will be given to registred doctoral students with projects concerning human brain in health and disease,Urval av studenter : for whom detailed knowledge of human brain anatomy is required.

The course is part of the FRONTIERS IN NEUROSCIENCE Course series. The course is from Friday toYtterligare information : Saturday and will include invited international speakers Nenad Bogdanovic from London/Stockholm, Ivica Kostovic from Croatia,Harry Uylings from Amsterdam and Helen Barbas från Boston. This course is a shorter version of the previously given course byNenad Bogdanovic and will include the first part of the previous course 1800. Observe that the last course practical day is on aSaturday and students will be able to prepare exam during following 4 days until the 12st of September. The course will be given atthe Pathology Department at Karolinska University Hospital Huddinge.

Kursansvarig : Nenad BogdanovicInstitutionen för neurobiologi, vårdvetenskap och samhä[email protected]

Kontaktpersoner : Anna Fogdell-HahnInstitutionen för klinisk neurovetenskap

[email protected]

CMM

Solna

Title : Advanced seminars in cancer biology incl. infection-associated cancers




Särskild behörighet : At the end of the course the students will have an updated overview of the cutting edge research activitiesKursens lärandemål :

within the fields of cell- and tumor-biology, also with some focus on the molecular and cellular mechanisms involved ininfection/inflammation-associated carcinogenesis. ¿The student will also enhance their analytical and critical thinking to discussadvanced problems in cell- and tumor biology, beyond what is found in text books, and evaluate the relevance of the topicspresented in the context of their own research activities and PhD studies. ¿¿At the end of the course the students will be able todiscuss about several main aspects of tumor biology, including apoptosis, cell cycle, cancer stem cells, virus andbacteria-associated cancer, effects of chronic inflammation in carcinogenesis, epigenetics, tumor immunology, proteomics of cancer,angiogenesis, and development of new treatments as well as some key issues in clinical cancer research.

The course is organized to contain approximately 20 seminars/lectures, held by invited national andKursens innehåll : international prominent researchers. The speakers will organize their talks to give a comprehensive and pedagogical overview of theresearch area as well as an in depth discussion of their own research. Each seminar will be followed by a discussion led by thecourse organizers where the students are encouraged to interact with the invited speaker. To enable a fruitful discussion thestudents will be encouraged to study the most recent literature, still not present in the text books within the presented filed. Thetopics presented will cover the main aspects of tumor biology, including apoptosis, cell cycle, cancer stem cell, virus andbacteria-associated cancer, effect of chronic inflammation in carcinogenesis, cancer genetics and epigenetics, tumor immunology,proteomics of cancer, angiogenesis, and development of new treatments as well as key issues in clinical cancer research.

The course will consist of approximately of a 45 minutes seminar at least once a week during one semester. At theArbetsformer : end of each seminar there will be a discussion led by one of the course organizers. To increase the learning process and tostimulate the reflection on the seminars, the students will be asked to study the most recent literature, still not present in the textbooks within the presented fields.

As assessment, the students will write an in-depth assay on a subject within the scope of the course. The assays willExamination : be evaluated by the course organizers.

Attendance to the seminars and the written assay are compulsory. Missed seminars can be compensatedObligatoriska moment : by other activities after discussion with the course leaders.

20 - 30Antal studenter : If there are more candidates than places available, we will take into account 1. students own motivation forUrval av studenter :

being accepted to the course 2. The research project of the student 3. Registration date as a doctoral student.The course is organized to contain approximately 15 seminars/lectures, held weekly by invited nationalYtterligare information :

and international prominent researchers. We will have Tuesday has the main seminar day, but some changes can occur dependingon the invited speaker. Seminars will take place mainly at MTC or CMB at 13.00 o'clock. The speakers will be asked to organizetheirtalks to give a comprehensive and pedagogical overview of the research area as well as an in depth discussion on their ownresearch. The detailed seminar list with information regarding, speakers, titles and venues will be send by e-mail to all the studentsin due time, and weekly reminders will also be send out.

Kursansvarig : Ingemar ErnbergInstitutionen för mikrobiologi, tumör- och [email protected]

Box 280, Karolinska Institutet

17177Stockholm

Kontaktpersoner : Teresa FrisanInstitutionen för cell- och molekylä[email protected]

Berzelius väg 35

S-17177Stockholm

Title : Clinical achievements of reproductive medicine




Särskild behörighet : The objectives of this course are that at the conclusion of this course students should be able to have aKursens lärandemål :

comprehensive view of: -The key factors involved in gamete biology, gamete physiology and in vivo and in vitro fertilization -The keyfactors involved in early embryo development and implantation -The clinical achievements of modern reproductive medicine andAssisted Reproduction Techniques (ART) -The causes of subfertility and infertility and the current therapeutic approaches -The linkbetween genetics and male/female infertility and the implications in ART -The difference between chromosomal and DNA-basedgenetic disease and the different technologies to detect them -The basic genetic technology used in Preimplantation GeneticDiagnosis (PGD) -The in vitro systems, culture systems and work stations used in ART -The influence of the laboratory and clinicenvironment on embryo culture -The assessment of developmental potential and the morphological aspect of normal oocytes,zygotes, cleavage stage embryos, morulae and blastocysts -The implantation process -The pathophysiology of repeated earlypregnancy loss and ectopic pregnancy -The general aspects, implication and clinical applications of stem cells research -The noveldevelopment of ART for fertility preservation, cryobiology and transplantation -The epigenetic aspects of assisted reproduction

Contents: Biology of the gametes, fertilization and early embryo development Normal and pathologicalKursens innehåll : implantation, early pregnancy loss, ectopic pregnancy, repeated miscarriage In vitro spermatogenesis and oocyte maturation Clinical investigation and therapeutic approach on female and male infertility Genetics in infertility Gonadal dysgenesia Stem cellsresearch Assisted reproduction techniques (ART) In vitro systems and cultures Cloning. Somatic cell nuclear transfer Clinicalaspects of fertility preservation Cryobiology systems for fertility preservation Pre-implantation genetic diagnosis Epigenetics inassisted reproduction Experimental reproductive tissue transplantation procedures: -ovarian and testicular tissue transplantation -transplantation of the uterus

lectures, seminaries/discussion and laboratory demonstrations Arbetsformer : Written examination and discussion Examination :

All teaching activities, the laboratory sessions and the lectures are obligatory. In case of not attendance toObligatoriska moment : the activities, students should produce a literature work related with the subject of the missing activity.

6 - 12Antal studenter : PhD students having research projects in reproductive medicine/reproductive biology would be prioritized,Urval av studenter :

other students may provide a motivation letter for participating in this courseOne week fulltimeYtterligare information :

Kursansvarig : Kenny Rodriguez-wallbergInstitutionen för klinisk vetenskap, intervention och [email protected]

Fertility Unit K59Karolinska Universitetssjukhuset Huddinge141 86Stockholm

Kontaktpersoner : Kenny Rodriguez-wallbergInstitutionen för klinisk vetenskap, intervention och [email protected]

Fertility Unit K59Karolinska Universitetssjukhuset Huddinge141 86Stockholm

Jose InzunzaInstitutionen för biovetenskaper och näringslära08-585 850 [email protected]

Hälsovägen 7, Novum

141 86Stockholm

Cecilia GotherstromInstitutionen för klinisk vetenskap, intervention och [email protected]

Klinisk Immunologi F79Karolinska Universitetssjukhuset Huddinge14186Stockholm

Title : Basic immunology




Särskild behörighet : To understand basic principles of innate and adaptive immunity and how different components of theKursens lärandemål :

immune system cooperate. To be able to relate, compare and understand experimental aspects of immune-related disease in aclinical perspective. To adapt knowledge gained of the function of the immune system by being able to analyze and discuss animmunological/clinical case (group project). To present the group project and discuss the results as well as work in pairs with clinicalcases.

The course is separated into two parts. In part 1 we discuss basic immunological mechanisms within the innateKursens innehåll : and adaptive immune response. In part 2 we apply the knowledge in clinical settings such as defence against infection, autoimmuneand allergic disease or transplantation. Part 1: Introduction An overview of the immune system T cells B cells Antigen-presentingcells Innate vs adaptive immune responses Methods to study immune reactions. Part 2: Immune defence against bacterial andviral infections Primary immunodeficiencies Autoimmune disease Allergy Vaccination Clinical Immunology Transplantation Tumour Immunology Questions and discussions Presentation of projects.

The course is given full-time during a total of six days separated into two parts. The teaching is mainly inArbetsformer : lecture/seminar form but also includes project work studying cases individually and pairwise, as well as in small groups. The groupprojects are then presented orally on the last day of the course. The project work requires studies between the two course parts,including meetings with mentors. Course literature (Abbas) and cases are handed out at the course start. An immunological quiz isconnected to the different chapters in the book so that the student will be able to digest the relatively big material. The course isdesigned so that clinically active doctors will be better able to combine it with work in the clinic (Mondays and Fridays contain noscheduled course work) .The purpose of dividing the course into two parts is that the participants should have time to thoroughlystudy the literature from part 1 (fundamental immunological mechanisms) before teaching of the applied immunology in part 2 starts.Considering the substantial literature requirement plus the cases and project work, we estimate that an extra 32h of study is needed,which is not included in the schedule.

Web-based exam on the course content. Oral presentations of small-group project work. At this occasion specialExamination : attention is given to that all students are actively participating. The clinical cases are examined by written reports.

Project work and attendance at the project presentation is compulsory as well as work with two clinicalObligatoriska moment : cases. In the case of absence a separate occasion is organized with presentation for the course organizers. The web-based exam ismandatory.

15 - 35Antal studenter : Selection of students is based on 1. Motivation to attend the course 2.Date of acceptance as doctoral student. Urval av studenter :

The course is divided into two parts, consisting of three days each (tuesday to thursday 18-20 SeptemberYtterligare information : and 23-25 October). Between the two parts the participants perform project work, including meetings with mentors as well as studythe literature. Teachers include specialists in different fields of immunology including both basic and clinical researchers: examples:Peter Bergman, Ola Winqvist, Rolf Kiesling, Helena Erlandsson Harris and Guro Gafvelin. Litterature includes Abbas (BasicImmunology) and clinical cases as well as handouts etc.

Kursansvarig : Jan WahlstromInstitutionen för medicin, [email protected]

Lungforskningslab L4:01Karolinska Universitetssjukhuset, Solna171 76Stockholm

Kontaktpersoner : -

Title : Functional Fluorescence Microscopy Imaging (fFMI) in biomedical research




Särskild behörighet : At the end of the course the student should be able: 1. to use fundamental aspects of molecular structure toKursens lärandemål :

describe molecule (matter) interaction with light (electromagnetic radiation) and the emission of fluorescence, and to use thisknowledge to discuss fluorescent properties of a fluorophore and different labeling strategies. 2. to understand the fluorescenceimaging instrumentation, to define elements of a fluorescent microscope and to describe instrumentation properties in terms ofsensitivity. 3. to describe the theoretical background behind fluorescence based methodologies for studying molecular interactionsin live cells. Discuss pros and contras in relation to the biological problem studied. 4. to specify instrumental requirements and todesign a fluorescence imaging assay for a biological problem of interest. 5. to apply a specific labeling strategy and perform a livecell fluorescence imaging assay. 6. to document experimental work in accordance with Good Laboratory Practice (GLP) guidelines. 7. to communicate the results in written and oral form. 8. to discuss the adequateness of the methodology used in the scientificliterature concerned.

Fluorescence microscopy and associated techniques are becoming indispensable research tools forKursens innehåll : investigating molecular mechanisms of biological processes. Versatility of fluorescence based methodologies comes from themultifaceted possibility to characterize fluorescence emission by position, intensity, wavelength, lifetime and polarization. Thesemethodologies bring new biological insight at an unprecedented rate and are of crucial importance for the development of lifesciences. The course covers the following topics: Luminescence and the nature of light (Fluorescence, Phosphorescence, Lightscattering, Rayleigh-Tyndall scattering, Raman scattering); Fluorescent markers and their photophysical properties (Organicfluorescent dyes for covalent conjugation (Rhodamine 6G, Alexa dyes, Cyanine dyes); Quantum dots; Intrinsically FluorescentProteins (Aequorea victoria (GFP, YFP), Discosoma coral (DsRFP) and Montipora (Keima) families); Selectively binding andintercalating dyes (DiI, DraQ 5). Labeling strategies for biomedical application. Instrumentation for fluorescence imaging (Lightsources, Wavelength selection, Detectors, Read-out devices, Sample holders, Problems of high blank values, Cuvettes, Solventsand Reagents, Other contaminants); Quantitation and Sensitivity (Instrumental sensitivity, Method sensitivity, Absolute sensitivity);Factors affecting quantitative accuracy (Adsorption, Photo-decomposition, Oxidation, Temperature, pH, Inner-filter effects,Quenching); Fluorescence based methodologies for studying molecular interactions in live cells (FRET, FLIM, FRAP).Single-molecule detection (Quantitative APD imaging, FCS and FCCS). Non-linear microscopy (Multi-photon excitation, STED).Spatially resolved fluorescence imaging (STORM, PALM).

The course includes lectures, laboratory sessions, discussion sessions and a project work.Arbetsformer : The final assignment consists of a written project report (5 pages) and an oral presentation of the project report (15Examination :

min). All sessions are compulsory. Please report any absence to the course leader in advance by e-mail.Obligatoriska moment :

Absence from any part of the course (lectures, laboratory sessions, discussion sessions and exam) is generally not accepted butcould in special cases be compensated by an individually tailored additional module and a special written examination organized bythe course committee.

8 - 12Antal studenter : This is an advanced course on fluorescence microscopy imaging. Priority will be given to applicants who canUrval av studenter :

concisely (max 250 words) show in their application an urgent need to begin their independent work with live cells fluorescenceimaging.

This is a two weeks course, with 10 sessions (December 3-14, 2012). Nine sessions include lectures andYtterligare information : laboratory practice (4 h), and time for self-study. Last session is reserved for the examination. The total working load for thestudents is estimated to be 95 h (3 hp). Experimental exercises are carried out in the fFMI laboratory CMM, L5:02, 020a. Lecturesare conducted in the lecturing hall CMM L8:01, 021.

Kursansvarig : Vladana VukojevicInstitutionen för klinisk [email protected]

CMM L8:01

17176Stockholm

Kontaktpersoner : -

Title : Observation och video som forskningsmetod inom vårdområdet




Särskild behörighet : At the end of the course the student should -know how to do direct/naturalistic observations within aKursens lärandemål :

deductive approach by developing and using an observation protocol - know how to do participatory and not participatoryobservations within an inductive approach - know how to use video-observation as a means for data-collection - know how to test forvalidity and reliability - have an understanding of different methods used (quantitative and qualitative) for analyzing data generatedfrom the observations.

Developing and testing a protocol which can be used for both naturalistic observations and videotapes orKursens innehåll : performing video-observation which should be transcribed into text and further analyzed; testing observed data for validity andreliability. The content of the course is built on how to investigate interaction between people exemplified from a caring situation.

Lectures, seminars and individual assignments/project workArbetsformer : The student will in her/his project work and with the individual assignments demonstrate her/his knowledge andExamination :

ability to use naturalistic and video observations as a means for investigate interaction in a caring situation.The course in its whole needs active involvement of the student through participation in the various typesObligatoriska moment :

of learning.10 - 20Antal studenter :

Urval sker utifrån sökandes motivering att gå kursen.Urval av studenter : Kursdatum: 24-26 okt, 29-31 okt , 14-16nov.Ytterligare information :

Kursansvarig : Kyllike ChristenssonInstitutionen för kvinnors och barns hä[email protected]

Retziusväg 13A

171 77Stockholm

Kontaktpersoner : -

Title : Molecular localisation in cells using fluorescence microscopy




Särskild behörighet : After the finished course, the students will be able to describe the basics of the technology behindKursens lärandemål :

fluorescence and confocal microscopy, and the most common applications of these technologies in cell biology. The course contains both theoretical and practical modules or demonstrations focusing on the differentKursens innehåll :

techniques used for investigating molecular localisation in cells. These include different types of microscopes, sample preparation,immunostaining and visualization, and data analysis.

The learning forms include cathedral lectures, discussions, presentations, laboratory practicals and demonstrations.Arbetsformer : Examination reflecting the learning outcomes of the course is groupwise and individually with group projects andExamination :

demonstrations. The laboratory practicals and demonstrations are obligatory. Compensation with additional individualObligatoriska moment :

projects according to the instructions of the course director. 8 - 15Antal studenter :

The selection is based on the relevance of the course content to the doctoral project and the personalUrval av studenter : motivation written by the applicant.

The target group of the course is doctoral students using cell and molecular biology methods in theirYtterligare information : research. Students can bring their own antibodies and/or plasmid vectors for mammalian expression to study their own protein ofinterest. The course is full time and it is organized at the Department of Cell and Molecular Biology. The course is a collaborationbetween the doctoral course program in Cell Biology and Genetics and the DBRM Research school. The course web pages can befound at the DBRM Research school pages at www.dbrm.se.


[email protected]


Title : Mouse models of human cancer




Särskild behörighet : The aim of the course is to convey an enhanced knowledge about the generation and use of mouse modelsKursens lärandemål :

in cancer research, as well as to empower the student to make an informed decision of suitable models for his/her own researchsituation. After completion of the course, the student should be able to: - Compare and contrast different categories of mousemodels of cancer and analyze the pros and cons of models within each category - Apply state-of-the-art technology in the generationand use of mouse models of cancer - Relate the knowledge about mouse models of cancer to his/her own research - Independentlybe able to search for more information about mouse models of cancer

The course will provide an introduction to the generation and use of mouse models of human cancer. A surveyKursens innehåll : of the state-of-the-art technology in the field, such as conditionality, inducibility and imaging, will be provided. Also, the use of mousemodels in various applications related to cancer research, such as studies of metastasis or experimental therapy, will be reviewed.Mouse models of particular interest will be highlighted. In parallel, literature studies of mouse models of specific indications will beperformed by the students, with the aim of designing new and improved mouse models.

1. Lectures will provide knowledge about the current state of the field. 2. Case in point seminars will highlight mouseArbetsformer : models of cancer of particular importance. 3. Group assignments will be used to perform a literature review and gain insight intodisease-specific mouse models of cancer.

Course examination is composed of two parts: 1. Oral presentation and discussion of the group assignments, inExamination : which the students will present the design of a new and improved mouse model of human cancer. 2. Written exam, in which thestudent will relate and apply the knowledge gained during the course to their own research situation.

Attendance is compulsory during all scheduled time slots for the group assignment. Absence will beObligatoriska moment : compensated by a written report of an extra assignment for literature review.

8 - 16Antal studenter : The primary selection criteria are 1) the usefulness of the course for the doctoral student in his/her researchUrval av studenter :

project, and 2) the motivation given in the application to the course.The lectures will be given 19th to 22nd of November 2012 (full days). The participants will give oralYtterligare information :

presentations as part of the exam on 26. November. All course moments will take place in the Novum building, 4th floor, room"Kärnan", Huddinge (KI campus South).

Kursansvarig : Rainer HeuchelInstitutionen för klinisk vetenskap, intervention och teknik08 585 830 [email protected]

Kontaktpersoner : -

Title : Applied Bioinformatics



ForskarnivåNivå : Department of Biosciences and NutritionKursansvarig institution :

Solid fundamental knowledge of molecular biology, gene structure, genetics. Knowledge how to operate aSärskild behörighet : computer

After the completed course, the students should have the working knowledge and the skills needed for selfKursens lärandemål : supporting use of fundamental bioinformatics in research. They should understand the changing nature of DNA sequences duringevolution, what kind of information can be retrieved from sequence information, and be able to use bioinformatic tools to derive newresearch ideas from sequence information.

The course will introduce the basic bioinformatics tools that are required in biomedical research. It will coverKursens innehåll : basic methods such as DNA and protein sequence analysis, use of biological databases, database searches (e.g. blast), a briefintroduction to high-throughput sequencing, gene prediction, sequence alignment, sequence motifs, understanding of geneevolution, SNP analysis, phylogenetic analyses, and basic homology modeling of protein sequences.

The course is comprised of two parts. In general, in the morning lectures take place on a topic, and in the afternoonArbetsformer : a corresponding practical computer lab takes place to apply the theoretical knowledge with real examples. Each student will gethands-on practical experience with bioinformatic tools, such as blast and multiple sequence alignments.

Written examination with computer use. The knowledge and deductive skills taught in the lectures and practica willExamination : be examined.

Both lectures and computer lab are compulsory. Absences in the lectures or computer lab can beObligatoriska moment : compensated by doing practical exercise task(s), preparing a report of the task(s) and results, and submitting it to the course leaderfor review and approval.

10 - 20Antal studenter : The selection is based on the relevance of the course content for the doctoral project and the personalUrval av studenter :

motivation to attend the course. If space is available, advanced master students or students from outside KI can participate in thecourse. Solid fundamental knowledge in molecular biology, gene structure, genetics, and competence with operating a computer isexpected.

Preliminary schedule: Monday to Friday: lectures from 9.00 to 12.00, computer lab 13.00-17.00. Full timeYtterligare information : course. Course location: Alfred Nobels Allé 8, course room Mathilda. Preliminary list of lecturers: Thomas Bürglin, Peter Swoboda,Thomas Svensson

Kursansvarig : Thomas BurglinInstitutionen för biovetenskaper och näringslära5858 [email protected]

Kontaktpersoner : Thomas BurglinInstitutionen för biovetenskaper och näringslära5858 [email protected]

Title : Methods in molecular biology and their applications in medical research




Särskild behörighet : After the course, the students will understand the principles, from both a theoretical and practical viewpoint,Kursens lärandemål :

of a number of basic techniques used in DNA/protein research and their application in medical research. The students should alsobe able to design and perform investigations with some of the discussed techniques.

The aim of this course is to confer knowledge of how basic molecular biology and protein work can be applied inKursens innehåll : clinically oriented research work. The course is designed for graduate students with limited experience of molecular biology andcombines a lecture program with laboratory work. The lectures will include theoretical and practical aspects on basic conceptsconcerning techniques in molecular biology and proteomics and their application in medical research. Specified subjects will includecloning, RNA-analysis, promoter studies, DNA-sequencing, expression, bioinformatics, antibody based protein detection andproteomics. The overall objective is to convey knowledge of possibilities and limitations with different techniques and introducevaluable methodology for the students PhD-projects.

The course combines a lecture program in the morning with laboratory work in the afternoon, where courseArbetsformer : participants will be subdivided into smaller groups.

The students will be asked to solve a scientific problem using methods they learned during the course. The last dayExamination : of the course, the participants will give a presentation. They should be able to defend the laboratory design, discuss methodologiesapplied and anticipated results. The students will work in pairs. The task will be given to the participants at the end of the first week.

Laboratory work is compulsory. To compensate for absence, self-studies and an written essay on theObligatoriska moment : topic(s) that they have missed must be performed.

8 - 14Antal studenter : Students will be selected based on their motivation. Priority will be given to the doctoral students at the Urval av studenter :

beginning of their doctoral training and/or to the students with little experience in molecular biology. The course meets for 2 weeks full time. The lectures will be given by invited specialist from different fieldsYtterligare information :

and by the course organizers. Morning lectures will take place at Karolinska University Hospital, Huddinge. Labwork in the afternoonis held at the lab in Dentist School, floor 8, Alfred Nobels allé 8, Huddinge. Some lectures and demonstrations will be given at KISolna campus. Laboratory work is compulsory and are expected to be finished on 12th of September and final examination will takeplace on the 14th of September.

Kursansvarig : Camilla PramfalkInstitutionen för laboratoriemedicin

[email protected]

Kontaktpersoner : Gosta EggertsenInstitutionen för [email protected]

Agne KulyteInstitutionen för medicin, Huddinge

[email protected]

Jurga LaurencikieneInstitutionen för medicin, Huddinge

[email protected]

Title : Medical nanosciences




Särskild behörighet : After successful completion of the course the course the student will: 1) have a deepened interdisciplinaryKursens lärandemål :

understanding of the fields of nano-engineering, nanotechnology and bioelectronics, 2) be able to apply such technologicalapplications in the PhD project of the student.

The course is mainly aimed for doctoral students from the fields of biomedicine, medicine and engineering withKursens innehåll : an interest in recent developments and biomedical applications of nanotechnology. Thus, the topics covered will include organicbioelectronics, principles of micro- and nanofluidic devices, application of polymers and nanoparticles, miniaturized biosensors andadvances in electron microscopy.

The course is based on a series of lectures, and interactive discussions with the teachers. The course will be givenArbetsformer : in the form of a retreat, and an interactive task.

The examintion task will be to solve a complex question based on a selected collection of scientific articlesExamination : distributed before the start of the course and on the lectures. At the end of the course, the students will give a shortpower-point-based presentation defining the solution to the question.

Attendance of the retreat and completion of the student task are mandatory. Compensatory written taskObligatoriska moment : will be given, should any of the lectures be missed.

10 - 16Antal studenter : Students will be selected according to the relevance of the course for their research training and on their Urval av studenter :

motivation. If space allows, the course will also be eligible for master students.This course is given in a retreat format at Hässelby Slott and the students will be staying at the conferenceYtterligare information :

site for the whole course. No cost is involved, meals are included. The course consists of two parts; a graduate education retreatand a problem-based task. The retreat will consist of lectures and seminars, as well as panel discussions between the students andthe teachers. The accepted applicants will be provided with the problem-based task before the course dates, as well as with suitablesuggestions for literature. The students will present their solutions to the task at the retreat.

Kursansvarig : Andreas NyströmInstitutionen för [email protected]

Retzius väg 8

17177Stockholm

Kontaktpersoner : -

Title : Undervisning och lärande i högre utbildning: doktorandkurs i pedagogik




Särskild behörighet : Syftet med kursen är att bidra till doktorandens utveckling som professionell universitetslärare genomKursens lärandemål :

förberedelse för undervisning. Vid slutet av kursen förväntas studenten uppnå följande lärandemål: - Känna till den professionellauniversitetslärarens villkor och roller. - Kunna använda pedagogiska begrepp i resonemang om undervisning och lärande. - Planeraundervisning utifrån principer om målrelaterad undervisning och teorier om lärande.

- Den professionella universitetslärarens villkor och roller - Studenters lärande i teori och praktik -Kursens innehåll : Undervisningsformer och metoder - Undervisningsplanering

Kursen baseras på teorier om erfarenhetsbaserat lärande, ett reflekterande förhållningssätt och lärande viaArbetsformer : deltagaraktivitet och samarbete dvs. kursen bygger på ett pedagogiskt synsätt som innebär att kursdeltagarna förväntas delta aktivt ikursens olika moment. Arbetsformerna varieras utifrån t ex föreläsningar, grupparbete och olika seminarieformer. Arbetsformernaska fungera som stöd för lärande men också som modeller att använda i egen undervisning. Mångfald och likabehandling i relationtill undervisning och lärande beaktas under kursen.

Examination sker genom att deltagaren: 1) Planerar och granskar ett eget undervisningstillfälle och redogör för dettaExamination : i en skriftlig inlämningsuppgift. 2) Auskulterar en annan lärares undervisning, genomför en intervju med läraren och redovisar dettamuntligt. För att godkännas på kursen krävs att kursdeltagaren når samtliga lärandemål i enlighet med specifikabedömningskriterier och deltar i obligatoriska moment.

- Aktivt deltagande i ett litteraturseminarium. - Aktivt deltagande i ett examinerande seminarium. -Obligatoriska moment : Kamratbedömning och återkoppling på en skriftlig examinationsuppgift. Frånvaro vid obligatoriska moment kompenseras medersättningsuppgifter.

15 - 25Antal studenter : Företräde har doktorander i vars individuella studieplan det anges att doktoranden undervisar eller skallUrval av studenter :

undervisa. Ange kortfattat i motiveringsfältet om det står inskrivet i din individuella studieplan att du undervisar eller ska undervisaunder din forskarutbildning. I andra hand sker urval utfrån registreringsdatum som doktorand.

Kursen motsvarar tre veckors studier och kräver eget arbete utanför schemalagd tid. Schemalagda dagarYtterligare information : är följande: 19-23 nov, 26-30 nov och 17-21 dec. Kursen hålls på svenska / Course is given in swedish.

Kursansvarig : Linda BarmanInstitutionen för lärande, informatik, management och etik

[email protected]


Title : Public health intervention and implementation research




Särskild behörighet : At the end of the course the student should be able to: 1. Define core concepts in intervention andKursens lärandemål :

implementation research 2. Understand the concept of evidence-based public health 3. Understand how to critically appraisepublished intervention and implementation studies, as well as systematic reviews in public health 4. Design an intervention study,which includes a relevant problem theory and a programme theory, as well as appraisal of ethical aspects 5. Design theimplementation of an evidence-based programme or practice, and describe the design of the evaluation

As this course aims at giving doctoral students knowledge in theory, method and practice in the field of publicKursens innehåll : health intervention and implementation research, the content focuses on the following themes: 1. Models and frameworks, includingcore concepts and their interrelation, within the field of intervention and implementation research 2. How to apply a theoreticalperspective based in public health science, using relevant change theories 3. Models of intervention and implementationprogrammes in a multilevel perspective and the design of evaluation studies 4. Intervention and implementation core components,success factors and barriers 5. Application of ethics on specific subjects/areas of intervention, implementation and evaluation 6.Systematic and critical appraisal of published intervention and implementation studies 7. Dissemination of scientific results

The course is based on lectures in combination with seminars in order to promote a reflective, analytical and criticalArbetsformer : approach towards this research field. The course will also use group work and group discussions to promote the students activeparticipation in their learning process, as well as the ability to accomplish tasks both individually and in groups. All teaching activitiesaim at enhancing the student¿s ability to apply for example core concepts and theory/theoretical frameworks, not the least ethicalaspects, in an analytical and reflective practice of their own in order to apply this on the students own research projects.

The students¿ knowledge and skills in theory, method and practice in the field of public health interventions andExamination : implementation research will be assessed in relation to the expected learning outcomes through the following examinations: a.Active participation in seminars with presentations, in discussions and short seminar reports b. A written project report and an oralpresentation of the report

Participation in scheduled seminars and group work is compulsory. Absence is compensated through aObligatoriska moment : written summary of the literature for the seminar where the absence occurred.

12 - 20Antal studenter : Priority will be given to doctoral students doing research in the field of intervention and/or implementationUrval av studenter :

research The course is part of the programme in Public Health Science. We will meet one or two days per week atYtterligare information :

the beginning of each week. The course will be held at the Institute of Environmental Medicine.

Kursansvarig : Lydia KwakInstitutet för miljömedicin

[email protected]

Kontaktpersoner : -

Title : SPSS I - datahantering för att beskriva dina data



ForskarnivåNivå : Department of Clinical Science and Education, SödersjukhusetKursansvarig institution :

Grundläggande statistikkunskaperSärskild behörighet : Efter kursen skall doktoranden: - Ha grundläggande kunskaper om statistikprogrammet SPSS (tidigareKursens lärandemål :

PASW) för att skapa strukturerade datafiler, modifiera data, samt skapa grafer och tabeller med hjälp av programmets menysystem. - Självständigt kunna skapa en datafil utifrån ett protokoll/enkät och mata in data. - Självständigt kunna definiera, sortera, modiferaoch selektera data för enklare situationer. - Självständigt kunna skapa grafer och avancerade tabeller och göra enklare redigeringar. - Ha en grundläggande insikt om olika typer av fel som kan uppstå vid datahantering.

Syftet med kursen är att stödja doktoranden att snabbt komma igång med statistikprogrammet SPSS. KursenKursens innehåll : vänder sig främst till kliniker och andra doktorander som planerar att använda SPSS för datahantering och analys underforskarutbildningen och vill få en överblick över programmet och dess möjligheter på ett strukturerat sätt. Kursen fokuserar pådatahantering och att beskriva ett datamaterial. Statistiska tester för att jämföra grupper och tidpunkter behandlas ej. Därav följandeinnehåll: -Grunderna i SPSS: Dataeditor, ouput-, syntaxfönster -Skapa nya variabler och bestämma format: numerisk, string, datum -Mata in, förklara och förtydliga data -Att definiera bortfall -Rutiner för att kontrollera data -Beskrivande statistik och korstabeller -Skapa och redigera avancerade tabeller -Sortera, selektera och skapa delgrupper i ett datamaterial -Koda om data och skapavariabler från dina befintliga variabler -Introduktion till syntaxer för att dokumentera datahanteringen -Introduktion till att räkna meddatumvariabler -Skapa och redigera grafer -Slå ihop datafiler -Praktiska tips och trix för att spara tid och minska risken för fel

Datorövningar kombinerat med katedrala moment. Föreläsaren går igenom och demonstrerar de olika momentenArbetsformer : och därefter får du själv arbeta med övningsuppgifter under handledning. Varje doktorand får tillgång till dator med SPSS.

Varje doktorand lämnar enskilt in lösningar till ett antal uppgifter baserade på datorövningarna under kursen. Tid förExamination : att lösa dessa uppgifter avsätts under kursen med möjlighet till löpande feedback från lärare.

Vid frånvaro från datorövningarna får doktoranden göra kompletterande övningsuppgift/-er. Obligatoriska moment : 15 - 20Antal studenter :

Registrerade doktorander har förtur. Datum för doktorandregistrering används som urvalskriterium där de somUrval av studenter : har varit registrerade längst har förtur.

Kursen ges på Södersjukhuset av institutionen för klinisk forkskning och utbildning (KI SÖS). HeldagarYtterligare information : 9-16. Kurslokal meddelas senare.

Kursansvarig : hans PetterssonInstitutionen för klinisk forskning och utbildning, Sö[email protected]

Kontaktpersoner : -

Title : Science education in emergency medicine




Särskild behörighet : After the completed course, the students will be able to design a small scale project and write theKursens lärandemål :

corresponding research plan. The students will be able to give short oral presentations of a research project and write a researchreport following the principles of scientific communication. The students will be able to make systematic literature searches andcritically appraise scientific articles. The students will be able to demonstrate the ability to link clinical research to basic science andvice versa.

The course consists of theoretical and practically oriented themes. The major topics covered include: design ofKursens innehåll : research projects, research methods, information competency, science communication, research ethics, research funding andpractical research economy, laws, rules and regulations, good research practice. Practical steps in initiating and conductingresearch activities in a clinical setting (clinical research ladder). Recruiting a team and supervision of students. Risk/benefit analysisin different medical, ethical and logistical contexts using scientific methodology. The practically oriented themes are centered aroundresearch in emergency medicine and relevant translational research aspects.

The learning activities on the course consist of lectures, group discussions, student presentations, research planArbetsformer : and report writing, peer-reviewing student projects and information searches.

The assessment is both formative and summative. The students are examined formatively with individual and groupExamination : presentations, and summatively with an individual abstract of a research plan.

Participation in the group discussions and student presentations is mandatory. Compensation according toObligatoriska moment : the instructions of the course director

1 - 2Antal studenter : The selection is based on the relevance of the course content for the doctoral project of the student and theUrval av studenter :

personal motivation letter to attend the course.The course is full time. It is organized by the DBRM Research school in collaboration with SWESEM.Ytterligare information :

More information about the course can be found at www.dbrm.se and at www.swesem.org. The course venue is the seminar roomA216 at CMB, Berzeliusv 35 in Solna.


[email protected]

Kontaktpersoner : -

Title : Cancer cell energy metabolism




Särskild behörighet : Describe and explain the role of metabolic shifts in cancer development and progression Reflect upon theKursens lärandemål :

interaction between oncogenic signaling and tumor metabolism Conceptualize tumor metabolic features in oncologic applicationswith a basis in the student¿s research area Analyse how tumor metabolism may be exploited in anticancer therapies anddiagnosis/prognosis

The course will provide an introduction to cancer metabolism. The role of oncogenic signaling and tumorKursens innehåll : microenvironment as drivers of tumor development and progression will be discussed because of their identified connections withcancer metabolic features. Therapeutic and diagnostic perspectives exploiting the altered cancer metabolism will be discussed.

The course will contain lectures, seminars and workshops for discussing student¿s projects with some of the invitedArbetsformer : speakers

Students are asked to describe and discuss a brief research project, possibly related to their own PhD project andExamination : using the concepts and knowledge acquired during the course. A 15 minutes oral presentation of the assignment with peer-basedfeedback is required.

Attendance to lectures from invited international speakers and participation to the workshops session areObligatoriska moment : strongly adviced to students. Students may compensate by a written report or by discussing the missed subject with the coursecoordinator.


project, and 2) the motivation given in the application to the course.The course will be taken from monday to thursday with lectures and seminars, at Cancer CentrumYtterligare information :

Karolinska. Besides lecturers from KI, three international experts in the field will be invited to give lectures/seminars and for adiscussion session with the students. The last day of the course is dedicated to the examination

Kursansvarig : Angelo De MilitoInstitutionen för [email protected]

Instrumentvägen 39

12653Hägersten

Kontaktpersoner : Mimmi ShoshanInstitutionen för onkologi-patologi08-517 754 [email protected]

Title : Basics of Qualitative research



ForskarnivåNivå : Department of Clinical Science and Education, SödersjukhusetKursansvarig institution :

Särskild behörighet : At the end of the course the participants will be able: 1. To describe experience of a classroom climate thatKursens lärandemål :

incorporates principles of respect, mutuality, cooperation, collaboration, and teamwork. 2. To apply knowledge of qualitativeresearch methods for discussing rationales for the design of the qualitative inquiry 3. To critically compare of qualitative andquantitative research (basic assumptions of the qualitative research paradigm as it compares to the quantitative paradigm) 4. Todescribe the common essential elements of qualitative research including How to select the appropriate: qualitative researchmethods based on phenomenon of interest setting for data collection study participants data generation strategies (includingindividual interviews, focus group discussion, written narratives, participants observation and field notes) and data analysis method5. To critically comments on/evaluate the weaknesses and strengths of the studies(published papers) using qualitative research interms of research question, aim and method 6. To design a qualitative research proposal in field of health

The course will provide some of the most important information which students need to understand andKursens innehåll : implement successful qualitative research methods (including the common essential elements of qualitative research). In additionthe course will provide step by step guidance to examine and apply current qualitative methodologies as a way to generate,manage, analysis qualitative data and moreover ,ethical considerations. The course will starts with the definition of qualitativeresearch, basic assumptions and characteristics of qualitative research in comparison to quantitative research. Following that will bethe notion of some common essential elements in qualitative methods such as: selecting the methods based on phenomenon ofinterest, using the literature review, choosing the setting for data collection, selecting participants, generating data and contentanalysis .After that , practical principle to do qualitative inquiry will be addressed. Finally ethical considerations in qualitativeresearch will be explained.

The learning activities on the course are a mix of lectures, discussions, individual and group; interview, seminar,Arbetsformer : field observation and individual presentations.

The course assessment will include formative and summative assessments. The formative assessment (50%) will beExamination : made through Peer learning Activity, critic a qualitative paper, individual and group presentation, while summative assessment(50%) will be through a written examination and individual qualitative proposal. In this way, the students are examined with bothgroup-wise and individual presentations.

Active participation in the class discussions, individual and group assignment (individual and groupObligatoriska moment : interview and field observation), written assignment (an abstract of a qualitative proposal) and student presentations is mandatory.Compensation according to the instructions of the course director, which means absentees less than 2 lectures is acceptable andshould be compensate by individual project related to absentee¿s session.


project, and 2) the motivation given in the application to the course. The course will be held at the Department of Clinical Science and Education, Södersjukhuset. InvitedYtterligare information :

Teachers: Professor Eva Johansson, PHS KI and others.

Kursansvarig : Hamid KhankehInstitutionen för klinisk forskning och utbildning, Södersjukhuset

[email protected]

Sjukhusbacken 10118 83

Stockholm

Kontaktpersoner : Jeanette Brynholt OhrmanInstitutionen för klinisk forskning och utbildning, Sö[email protected]

Title : Research documentation: theory and real examples




Särskild behörighet : After completion of the course the participants should be able to understand how to and document theirKursens lärandemål :

research in a way that ensures traceability and high quality according to the current legislation and rules. Among other things theparticipants will be able to utilise the electronic support systems for handling of research and research documentation available atKI. The participants should also be able to utilise the possibilities for large scale medical research that exist in Sweden.

The course includes an introduction to how research at KI should be documented and how electronic supportKursens innehåll : systems (ELN and LIMS) can be used to improve the documentation. Legislation regulating biobank samples and research registriesis presented and information is given regarding mandatory applications and how they can be used to complement the research. Theparticipants¿ own research (or, if necessary, course examples) will be used as examples and connects theory with practicalsessions that will make out the examination part of the course.

Lectures will be alternated with demonstrations and practical sessions for ELN, LIMS and application of the differentArbetsformer : parts of the course.

The examination of the course will be a written and oral presentation by the participants on how they can use whatExamination : they have learned during the course for their own research.

The whole course is mandatory. Absence from the practical sessions and/or the final presentationObligatoriska moment : (examination) must be compensated according to an agreement between the course responsible person/examiner and theparticipant in order to avoid a ¿non-pass-grade¿.

15 - 20Antal studenter : Selection will be based on the motivation by the student to take the course and the date of registration as aUrval av studenter :

PhD-student. The course will be some days in Solna and some days in Huddinge. Ytterligare information :

Kursansvarig : Cecilia BjorkdahlInstitutionen för medicinsk epidemiologi och biostatistik08-524 872 [email protected]

Kontaktpersoner : -

Title : Mass spectrometry-based proteomics: When and How.




Särskild behörighet : After completed the course, the student will be able to * Define and apply common proteomics terminology *Kursens lärandemål :

Illustrate the overview of proteomics * Recognize the principles of the most common proteomics techniques * Describe proteomicsworkflow: Experimental design, sample preparation and selection of techniques * Illustrate proteomics to such an extent that he/shewill be able to utilize the proteomics core facilities or collaborate with proteomics researchers. * Define the false discovery rate ofprotein and peptide identification of the protein identities based on the peptide confidence levels. * Demonstrate how modernproteomics is applied to clinical research and to evaluate when proteomics research could be beneficial to incorporate in researchprojects. * Design their own research project by mass spectrometry based proteomics.

* Overview of proteomics * The proteomics workflow * Basic of separation sciences: Protein and peptides *Kursens innehåll : Introduction to Mass spectrometry * Experimental design * Sample preparation, immunoprecipitation and enrichment strategy *Quantitative and qualitative proteomics by mass spectrometry * Comprehensive and targeted proteomics * Human protein atlas andBiological validation * Clinical applications * Current state of art in clinical proteomics is highlighted through case studies, literaturestudies and demonstrations.

The course contains lectures, literature studies with debate, seminars, and laboratory demonstration of proteomicsArbetsformer : techniques. The students will plan their own project as a case study as well as write a laboratory report.

* A written assignment of laboratory demonstration shall be handed in. * A literature study with a critical view on aExamination : mass spectrometry based proteomics subject shall be discussed in a literature/expert group. The literature group will debate andpresent their conclusions during the course. * Students shall describe a proteomics project (beneficially related to their research)including different aspects from the proteomics workflow. This is handed in as a written exam.

* Attendance at lectures and lab demonstrations. * Attendance at examination seminar and hand in theObligatoriska moment : written examination assignment. * Attendance at debate on the literatures regarding mass spectrometry-based proteomics. * Extrawritten literature study can be used to compensate absence. The students are recommended to read literatures listed below inadvance of the course.

10 - 24Antal studenter : Students will be selected based on their motivation. KI students are given priority but doctoral students fromUrval av studenter :

other higher education institutions are also mot welcome. The course is scheduled 9-17 Monday to Friday during the two course weeks (22/10 - 2/ 11 2012) atYtterligare information :

Karolinska Institutet Solna Campus (Karolinska University Hospital, Z4: Sievertrummet and Science for Life Laboratory). On the lastday (2/11), Students may have assignment as a home work, because of the day before all Saints day. The lecturers will come fromKarolinska Institutet, Karolinska University Hospital, Stockholm University and Royal Institute of Technology.

Kursansvarig : Kie KasugaInstitutionen för onkologi-patologi08 524 [email protected]

Tometebodavagen 23AKISP, Alfa Floor 117165Solna

Kontaktpersoner : Kie KasugaInstitutionen för onkologi-patologi08 524 [email protected]

Tometebodavagen 23AKISP, Alfa Floor 117165Solna

Helena BäckvallInstitutionen för [email protected]

Title : Omics data analysis: From raw data to biological information




Särskild behörighet : After completed course, the student will * Be able to use common chemomterics- and bioinformaticsKursens lärandemål :

terminology * Know the principles of some basic statistics such as t-test and false discovery rate. * Know the principles of PCA andPLS * Know when multivariate and univariate methods are applicable and how to apply them * Be able to evaluate a PCA and a PLSmodel * Know what normalization, data transformation, etc means and what it does to your data * Know the important aspects ofstudy design, experimental planning and sample selection * Be able to use tools for canonical pathway level analysis * Be able touse tools for GO annotation * Know tools for KEGG pathway analysis * Understand the analysis of ¿omics data to such an extentthat you will be able to take advantage of an 'omics core facility and collaborate with ¿omics data analysis researchers.

* The 'omics data analysis workflow * Clinical experimental design and sample selection * Introduction toKursens innehåll : statistics in 'omics data analysis: false discovery rate/p-values and fold change. * Qualitative vs quantitative data analysis *Accuracy and precision in 'Omics data. * Introduction to multivariate statistical analysis (PCA and PLS): Outlier and pattern analysisby PCA, supervised analysis by O-PLS modeling, finding significantly influential features, data model validity etc. (software: SIMCA) * Introduction to pathway analysis: the possibilities of canonical pathway analysis. (software: Ingenuity) * Case studies on clinicalbiomarker discovery * Literature studies with a critical view on how 'omics data is analyzed in clinical research. * Current state of theart in 'omics data analysis is highlighted through case studies, literature studies and demonstrations. The students will be able todownload some of the software tools and use on their own laptops during the course.

The course contains lectures, literature studies with discussions in seminars, and data analysis demonstrations. TheArbetsformer : students will also be able to use some of the software in workshops during the course.

* A literature study with a critical view on a data analysis 'omics subject shall be discussed in a literature/expertExamination : group. Discussion questions is reported and presented for the group. * The students shall do data analysis on a 'omics project(preferably related to their research) including the different moments taken up at the course. This is discussed in an examinationseminar and handed in as a written exam.

* Attendance on lectures and data analysis demonstrations * Attendance to examination seminar and handObligatoriska moment : in the written examination assignments. * Extra written literature study can be used to compensate absence.

12 - 24Antal studenter : Students will be selected based on their motivation. KI students are given priority but doctoral students fromUrval av studenter :

other universities are welcome to apply as well.The course is scheduled 9-17 Monday to Friday during the two course weeks (19/11 - 30/11 2012) atYtterligare information :

Karolinska in Solna. The Lecturers will come from Science for Life Laboratories; Karolinska Institutet, Stockholm University andRoyal Institute of Technology, and Umeå University.

Kursansvarig : Jenny ForshedInstitutionen för onkologi-patologi

[email protected]

Kontaktpersoner : Jenny ForshedInstitutionen för onkologi-patologi

[email protected]

Title : Cellular Reprogramming - from basal mechanisms to medical applications




Särskild behörighet : Upon completion of the course, the doctoral student will be familiar with mechanisms of nuclearKursens lärandemål :

reprogramming and how reprogramming techniques can be utilized in various research areas. Emphasis will be put on providing thestudent with knowledge to critically read and evaluate research work in the reprogramming field, as well as on how appropriatereprogramming methods and procedures can be applied in various research projects.

The course is composed of lectures that address different aspects of cellular reprogramming, i.e. how cellularKursens innehåll : identity can be changed, covering both basic scientific mechanisms as well as experimental procedures of cellular reprogramming.The primary focus will be on the reprogramming of fully differentiated cells to induced pluripotent stem (iPS) cells, but directreprogramming from one differentiated state to another will be discussed as well. Controlled differentiation of pluripotent cells tospecific fates and the use of cellular reprogramming in disease modeling will be discussed, and course participants will also beprovided with a practical demonstration of the reprogramming procedure.

The learning activities are a mixture of lectures, discussions, demonstrations, group seminars and individualArbetsformer : presentations.

The students are examined with individual presentations.Examination : Participation in the group discussions and student presentations is mandatory. Compensation is accordingObligatoriska moment :

to the instructions of the course director.10 - 15Antal studenter :

The selection is based on a comprehensive assessment based on the relevance of the course for the doctoralUrval av studenter : research project and the personal motivation written by the applicant.

The course is organized by the Research School of the Linné Center DBRM (Developmental Biology forYtterligare information : Regegerative Medicine). More course information can be found at the Research School web pages at www.dbrm.se. The course isfull time, given in English, and the course venue is the seminar room A216 at CMB, Berzeliusv 35.


[email protected]

Kontaktpersoner : -

Title : Writing Science and Information Literacy




Särskild behörighet : Demonstrate understanding of how to write an original scientific article and submit it for publication Kursens lärandemål :

Demonstrate ability to write other types of texts required for a scientific career Demonstrate ability to give, take, and make use ofconstructive criticism Demonstrate the ability to search and manage the medical sciences literature in a structured way Demonstratethe ability to use resources which facilitate choosing a journal to publish your research Describe aspects of post-publicationevaluation and processing of the medical sciences literature

Basic of scientific writing Writing an original scientific paper Supporting the text Writing in other contexts TheKursens innehåll : publication process Searching the literature Managing the literature Choosing a journal Evaluating published science KI-post-publication processing

This web-based course will be held using the learning management system PingPong. Content will be learnt withArbetsformer : various learning objects and learning practised by exercises. Formative feedback will be given by teachers/peer/self-assessment.Writing and IT skills will be developed.

The intended learning outcomes are assessed in the summative examination. Participants will write and rewrite aExamination : grant application and popular science summary based on teacher and peer feedback. Participants will also complete a number ofassignments which demonstrate their ability to use a number of relevant IT resources in a context of scientific communication.

There will be a number of obligatory tests and assignments to be completed.Obligatoriska moment : 18 - 22Antal studenter :

The selection for this general basic science course will be based on (1) your ranking of the applied course andUrval av studenter : (2) your admission date to doctoral education at Karolinska Institutet. Please make sure that you have put in the correct registrationdate for doctoral education at KI in your personal profile and that you have ranked the courses you have applied for.

Writing Science and Information Literacy (WSIL) Online is an entirely web-based distance course withYtterligare information : teacher support. There are no physical meetings during the course.


Berzelius 7B

17177Stockholm

Kontaktpersoner : -

Title : Basic principles in molecular imaging for medical diagnostics throughmagnetic resonance physics




Särskild behörighet : --To understand the basic principles of magnetic resonance (MR) and how these are implemented inKursens lärandemål :

magnetic resonance imaging and spectroscopy --To distinguish between anatomic and molecular imaging through MR. --To beable to interpret an MR spectrum, in general terms. --To be able to explain why mathematics are essential for processing of MRsignals. --To be able to conceptualize and generate new ways of thinking about the possibilities offered by more advancedmathematical approaches for processing MR signals, and how these could potentially impact upon medical diagnostics.

The basic principles of magnetic resonance physics, as these apply to Magnetic Resonance Imaging (MRI) andKursens innehåll : Magnetic Resonance Spectroscopy (MRS) are presented. We review how biological signals are processed with data analyticaltechniques in current practice, the limitations of these techniques as they impact upon clinical diagnostics and the potential impact ofnew analytical methods for improving detection of malignant and other pathological processes. 1. Introductory lecture: Molecularimaging through MR physics/an overview 2. Basic principles of magnetic resonance imaging and magnetic resonance spectroscopy(MRS). 3. Fundamentals of signal processing for medical applications 4. Magnetic resonance spectroscopic imaging (MRSI), safetyconsiderations in MR. 5. Review and future perspectives: Advances in signal processing for MR physics

The basis of the Course is lectures in which the students should strive to actively participate with questions andArbetsformer : comments. Handouts of each lecture with ample space for note taking will be provided. Each lecture will be accompanied byhomework which the students should prepare and to which they will receive detailed feedback. Group work is encouraged, as longas each student ensures that he/she has thoroughly and completely grasped all the material. There will be one open afternoon perweek during which students can meet with the teachers to ask questions and explore areas of interest. Before the examinationthere will be a practice oral examination for each student to test his/her knowledge and receive feedback from the teachers. It is ourexperience that students who attend all the lectures, complete the reading and homework, actively participate and attend thepractice oral examination will be able to handle the examination in a satisfactory manner.

The examination is written, closed-book. It is our experience that students who attend all the lectures, complete theExamination : reading and homework, actively participate and attend the practice oral examination will be able to handle the examination in asatisfactory manner.

It is vital that the students attend all the lectures and complete the homework. If the student has a validObligatoriska moment : reason for an absence, he/she will need to complete the reading for the lecture, turn in the homework and then come to the openafternoon for review and feedback.

5 - 20Antal studenter : We will strive to admit all applicants who would like to enter the course. If there are more applicants thanUrval av studenter :

places, we will preference to those nearer completion of their PhD, and then will plan another course for those who are earlier in thedoctoral program.

The lectures are tentatively planned for Monday, Wednesday and Thursday afternoons, and one more dayYtterligare information : will be devoted to more interactive learning sessions, with a focus upon the practical exercises. The students will also be able tocommunicate with the teachers via email. The specific content of the course is outlined in the course contents. Please, be aware ofthat the course requires two weeks of full-time dedication from those attending the course, inclusive self study and teacher-guidedstudying and examination.

Kursansvarig : Karen BelkicInstitutionen för onkologi-patologi

[email protected]

Karolinska Institutet Helicopter Bldg P9PO Box 26017177Stockholm

Kontaktpersoner : Karen BelkicInstitutionen för onkologi-patologi

[email protected]

Karolinska Institutet Helicopter Bldg P9PO Box 260

17177Stockholm

Title : Introduction to R statistical analysis for biologists




Särskild behörighet : After the completion of the course, the participants will be able to make use of R for exploring and analyzingKursens lärandemål :

data sets. More specifically, the participants will be able to manage data sets, perform descriptive data analysis, generate plots forgraphical display of data, and to perform tests such as Regression and ANOVA. A very specific goal is to provide the participantswith a long-term tool and the guidelines for improving their knowledge on it.

Data sets and formats in R. Descriptive statistics. Graphical display of data. Classical tests. Regression,Kursens innehåll : ANOVA, Kruskal-Wallis. Experimental design. Graphical display of analysis. Use of documentation in R.

The course consists of lectures, computer excercises and project work.Arbetsformer : The acquired knowledge and skills will be examined in two ways: by successfully completing computer exercises andExamination :

by a individual project (analysis of a selected data set; which can be provided by the student).Attendance is compulsory in lectures and computer excercises. Absence from obligatory moments isObligatoriska moment :

compensated according to the instructions of the course director.10 - 15Antal studenter :

Selection is based on the relevance of the course content for the doctoral project, and the personal motivationUrval av studenter : included in the course application.

The course takes place at CMB at KI Solna campus, in the seminar roomA216. Entrance Berzeliusv 35.Ytterligare information : The course director is Dr. David Gomez- Cabrero at the Department of Medicine, Solna. Email [email protected].


[email protected]

Kontaktpersoner : -

Title : Zebrafish cell biology and genetics - practical course




Särskild behörighet : After the completed course, the doctoral student can describe a number of modern techniques in biomedicalKursens lärandemål :

research using the zebrafish as a model. The student can describe and discuss ethical aspects of laboratory animal managementand welfare. The student can demonstrate practical skills in the basic handling of zebrafish, design the experimental set-up for astudy using this model, and critically evaluate and apply some of the basic techniques used.

The course contains lectures, practical demonstrations and excercises in animal husbandry and in technologiesKursens innehåll : such as embryo injections, whole mount in-situ hybridisations, zebrafish muscle physiology and fish motility.

The learning activities include practical work in groups, journaling, lectures and discussions.Arbetsformer : Examination reflecting the learning outcomes of the course is formative for the specific techniques involved, andExamination :

individually with log books (journaling) covering the practical parts of the course. The laboratory practicals and demonstrations are obligatory. Compensation according to the instructions ofObligatoriska moment :

the course director. 16 - 16Antal studenter :

The selection is based on an assessment of relevance of the course content for the PhD project, and on theUrval av studenter : personal motivation letter to attend the course.

The course will cover practical work and demonstrations of different techniques often used in zebrafishYtterligare information : biomedical research such as whole mount in situ hybridizations to detect expression of genes in early development, injections ofgene specific translation inhibitor DNA to produce morphant embryos, follow the in vivo development of zebrafish embryos in amicroscope and study movement and muscle physiology of young zebrafish. The practical part will also include how to handle theembryos and how to handle adult fish in the fish house. To identify mutant/transgenic fish there will be an exercise in fin clipping ofthe tail fin of adult zebrafish. The theoretical part of the course includes introduction lectures and research seminars frominternational speakers. The main venue of the course is CMB, seminar room A216, entrance Berzelius v 35 at CMB courtyard. Theoperative course pages are at www.dbrm.se, DBRM Research school. The course director is Monika Andersson Lendahl, [email protected].


[email protected]

Kontaktpersoner : -

Title : Plasticity in the auditory system



ForskarnivåNivå : Department of Physiology and PharmacologyKursansvarig institution :

Särskild behörighet : At the end of the course the student is expected to be able to describe the biological aspects of auditoryKursens lärandemål :

plasticity and the relevance for neuroscience. The students will be familiarized with the concept, mechanisms and consequences of activity¿dependentKursens innehåll :

synaptic plasticity in the central nervous system. In particular, the course will concentrate on the mechanisms by which electricalneurotransmission is linked to molecular signaling cascades, to regulate the efficacy of synaptic transmission. Special focus will beon the auditory system and speech processing.

Lectures from internationally known scientists in the field, and literature studies. Participating student will presentArbetsformer : their research in poster form and will present and defend their poster to the other students and scientists. The students will also writea 5 page essay on a topic within the course where they present a hypothesis and give rationale literature to support their theory.

Poster presentation and a written essay.Examination : The students will need to attend all lectures during the three days in order to pass the course. In case thatObligatoriska moment :

lectures are missed the student will compensate this loss by writing a short essay on the topic that they missed.10 - 50Antal studenter :

Students who have completed their half time control have priority. Selection will be performed from date ofUrval av studenter : registration.

The lectures will take place October 3-5 at a conference hotel in the Stockholm area (hotel Foresta,Ytterligare information : Lidingö). The lectures will begin on the Wednesday 3rd of October at 18:00 and end Friday after lunch. There is no charge for theboarding. Prior to the course the literature should be studied and a poster presenting your own research prepared.

Kursansvarig : Barbara CanlonInstitutionen för Fysiologi och [email protected]

Kontaktpersoner : -

Title : Competing risks and multi-state models: concepts, methods and software




Statistical modeling and inference using likelihood (course 2261) and Biostatistics III: Survival analysis forSärskild behörighet : epidemiologists (course 1685) or equivalent courses/practical experience (e.g., a masters degree in mathematical statisticscombined with application of survival models in medical research).

After successfully completing this course students should be able to: - describe the quantities that can beKursens lärandemål : estimated in a competing risks framework, how they are interpreted, and the assumptions that must be made. - understand therelationship between the cause-specific hazard and cumulative incidence and describe why it is no longer one-to-one in a competingrisks framework. - propose a suitable statistical model for assessing a specific research hypothesis in a competing risks situation, fitthe model using standard statistical software, evaluate the fit of the model, and interpret the results. - recognise when a multi-statemodel is appropriate, fit a multi-state model using standard statistical software, evaluate the fit of the model, and interpret the results.

Competing risks and its extension to multi-state models play an increasingly important role in the analysis ofKursens innehåll : time to event data. For competing risks models, there is a lot of confusion with respect to the proper analysis. The most importantreason for the confusion is conceptual: which quantities can be estimated and what do they represent. Especially the consequenceof violation of the independence assumption has often been interpreted incorrectly. Once the concepts are understood and theproper type of analysis has been chosen, most analyses can be performed with standard software for survival analysis. Formulti-state models with exactly observed transition times, estimation is reasonably straightforward; the real challenge is in (dynamic)prediction. Panel-observed data occur if the state is only known at a finite series of observation times, giving rise to interval censoredtransition times. A further complication arises if states are misclassified. With the recent availability of software we are seeing amarked increase in applications of multi-state models in the medical literature. The first part is devoted to competing risks. Weexplain the main concepts: the independence assumption; cause-specific cumulative incidence; cause-specific hazard andsubdistribution hazard; competing risks as a multi-state model. We discuss regression models on both cause-specific andsubdistribution hazard. We show how analyses can be performed with standard software. In the second part of the course, theextension to multi state models is discussed. Concepts like transition intensities and transition probabilities are explained.Nonparametric estimation and regression models are considered, as well as methods to obtain predictions of future events, giventhe event history and possibly covariable values of a patient. With right censored and/or left truncated data, we show that it ispossible to perform many types of analyses using standard software, using the same techniques as in the multi-state representationof the competing risks model. Finally, we discuss some issues in the analysis of multi-state models for panel data.

Lectures, exercises focussing on analysis of real data using statistical software, exercises not requiring statisticalArbetsformer : software, group discussions, literature review. The course will include practical exercises using the R statistical computingenvironment. We will provide laptop computers (running Windows in English and configured with R) for all participants, butparticipants are welcome to bring a laptop with them for use during the course if they prefer. The mstate and the dynpredR-packages will be used during the course and all participants who will bring their own laptops are encouraged to install thesepackages prior to the course.

The course grade is based solely on a written examination.Examination : Obligatoriska moment :

1 - 8Antal studenter : Applicants who have previously taken the course but not passed will be given first priority. Other eligibleUrval av studenter :

registered doctoral students will be prioritized 1) the relevance of the course for their research, and 2) the stated motivation forattending. Provide all relevant info. in the application, incl. description of current research and motivation for attending.

Face-to-face teaching will take place from 9:00-17:00 each day of the course. The majority of the teachingYtterligare information : will be held in Wargentin room at the Department of Medical Epidemiology and Biostatistics, Nobels väg 12A, KI Solna.

Kursansvarig : Paul DickmanInstitutionen för medicinsk epidemiologi och [email protected]

Nobels väg 12A

112 44Stockholm


[email protected]

Camilla AhlqvistInstitutionen för medicinsk epidemiologi och [email protected]

Title : Biologically based exposure assessment for epidemiology




Särskild behörighet : After the course the student should be able to account for the theoretical basis of exposure-response modelsKursens lärandemål :

and also be able to bridge the possible gap between exposure assessors and epidemiologists.Present the authors approach to the integration of exposure assessment and epidemiology. Contrast thisKursens innehåll :

approach to current practices. Explore the implications of the approach for the design and analysis of field studies. Illustrate theapproach with a wide range of examples. Discuss the implications of the approach for future research directions, for riskassessment, and for disease prevention.

The course consists of lectures, group seminars and group work presentationsArbetsformer : Presentation and discussion of group work. If necessary this is complemented by oral questioning (for individualExamination :

examination)Participation in group seminars and prensentation is mandatory. Absence can be compensated with anObligatoriska moment :

individual task.10 - 20Antal studenter :

The selection of students is based on the relevance of previous training and experience as well as on theUrval av studenter : individual motivation.

The main teacher is prof Thomas Smith from the School of Public Health, Harvard University, USA. He isYtterligare information : one of the leading experts in the exposure assessment with focus on biological modelling. The course will be based on his recentlypublished book A biologic approach of environmental assessment and epidemiology, T. Smith, D. Kriebel; Oxford University Press;2010; ISBN 978-1-10-514156-6

Kursansvarig : Nils PlatoInstitutet för miljömedicin

[email protected]

Kontaktpersoner : Catherine BollöInstitutet för miljömedicin08-524 870 [email protected]

Nobels väg 13, C2:4

Stockholm

Title : Neurogenetics




Särskild behörighet : I) The student will be able to understand and describe the major differences and uses of human geneticKursens lärandemål :

studies of neurogenetic diseases using i) Twin-studies, ii) population based studies, iii) case-control studies, iv) family studies.Students will have an in depth knowledge and understanding of selected neurologic conditions such as Alzheimer disease,trinucleotide repeat disorders, mitochondrial diseases, their genetic basis and an insight into the molecular pathogenesis, if known.II) The students will also be able to describe how genetic studies can be used to increase our understanding of the biological basisof neurological conditions. III) The students will be able to contribute substantially to critical evaluation and presentation of scientificarticles in the field of neurogenetics. IV) The students will have an understanding of the different genetic techniques and platformsavailable for studies in human (neurological) conditions.V) The students will have an insight in the application/use of genetic testingfor neurological diseases.

I) The course will give examples of how different types of genetic studies can help us identify genes involced inKursens innehåll : the pathogenesis of neurological disease: i) Twin-studies, ii) population based studies, iii) case-control studies, iv) family studies. II)The course will give examples of different gene defects in neurological diseases such as trinucleotide repeats, point mutations, copynumber variations, susceptibility genes, rearrangements, transciptional regulation and epigenetics. III) The course will provide an indepth understanding of the genetics of selected neurological diseases and how these genetic dysfunctions help us understand themolecular mechanisms of disease.

Daily class-room lectures. The last session on Monday through Thursday will be in a workshop/seminar formatArbetsformer : where the students prepare a group presentation of a selected topic/genetic neurological disease. The presentation will be on thelast day of the course and consitutes the examination.

The examination will be on the last day of the course and it will consist of i) participating in a group presentation of aExamination : selected topic/genetic neurological disease ii) participate as an active audience when other groups have their presentations.

All lectures/seminars are compulsory and in case of absence, the session can be compensated by a shortObligatoriska moment : written report using the literature after agreement with the course director.

12 - 14Antal studenter : Registered PhD-students studying neuroscience will be prioritized.Urval av studenter :

This course is part of the Series of FRONTIERS IN NEUROSCIENCE COURSES. The neurogeneticsYtterligare information : course will be held in the Huddinge Campus in Karolinska University Hospital, Huddinge.

Kursansvarig : Caroline GraffInstitutionen för neurobiologi, vårdvetenskap och samhä[email protected]

KIADRC, Novum plan 5

141 86Stockholm

Kontaktpersoner : -

Title : Epigenetics and its applications in clinical research




-Särskild behörighet : After this course the students will be able to: (i) describe the basic epigenetic mechanisms (DNA methylation,Kursens lärandemål :

histone modification and non-coding RNAs) and explain how they regulate gene expression, (ii) evaluate methodology used inepigenetic research, compare methods and discuss their advantages and limitations, (iii) evaluate and interpret new findings andrecent scientific papers in the field, (iv) speculate on epigenetic mechanisms underlying health and disease, and (v) hypothesize onapplications of epigenetic research in prediction, prevention and therapy of common diseases.

First part of the course includes overview of basic epigenetic mechanisms (DNA methylation, histoneKursens innehåll : modification, non-coding RNAs and chromatin organization). The course also covers methodology used to study epigenetics (suchas methods used to detect and quantify DNA methylation, chromatin immunoprecipitation, next generation sequencing andbioinformatics tools, chromosome confirmation capture etc). Second part of the course focuses on key epigenetic mechanisms incell development, differentiation and disease (cancer, inflammation, metabolic disorders etc). Current applications of epigeneticresearch in common diseases, and future perspectives will also be discussed.

The course combines traditional lectures, given by Swedish scientists and international experts in the field, withArbetsformer : case-studies performed by the students. Extra time for students' discussions with international speakers will be allocated. Thecase-study assignments will consist of designing a set of experiments to address given hypothesis. The hypothesis concernsepigenetic mechanisms in disease or application of epigenetics in clinical research. The assignment, performed in small groups,entails gathering and connecting relevant information, designing informative experiments, planning the project and then presentingand defending the project on the last day of the course. The students will also participate in evaluating and assessing case-studiesperformed by their peers.

Examination will be based on the successful completion of the case-study, presentation and interactive discussionsExamination : as well as involvement in assessment of case-studies presented by other groups (last day of the course).

All lectures, participation in case-studies, and assessment of case-studies are compulsory. CompensationObligatoriska moment : for absence (in a form of an essay) can be discussed with the course directors.

15 - 30Antal studenter : Selection will primarily be based on the proximity of the students' PhD project to the course topics, andUrval av studenter :

secondly on the time since PhD registration (priority will be given more advanced doctoral students).DATE AND TIME: 25th-28th of September (Tuesday-Friday), 9:00-16:30; and 3rd of OctoberYtterligare information :

(Wednesday) 9:00-14:00. LOCATION: Department of Biosciences and Nutrition, NOVUM, Huddinge (seminar rooms at level 5 & 6).THIS YEAR'S invited speakers include Prof K. Ekwall (histone modifications), Prof E. Hellström-Lindberg (cancer treatment withepigentic drugs), Dr B. Heijmans (environmentaly induced epigenetic changes), Prof R. Ohlsson (higher order chromatinorganization), Prof T. Ekström (epigenetics in health and disease), Dr O. Hermanson (neuronal development and cancer), Dr A.Pivarsci (micro RNAs), Dr C. Kanduri (non-coding RNA), etc.

Kursansvarig : Maja JagodicInstitutionen för klinisk [email protected]

Neuroimmunology Unit, CMM, L8:04

17176Stockholm

Kontaktpersoner : Karl EkwallInstitutionen för biovetenskaper och näringslära

[email protected]

Andreas LennartssonInstitutionen för biovetenskaper och näringslära08-524 811 [email protected]

Title : Stem cell engineering and regenerative medicine




Särskild behörighet : After the completed course, the students can describe a number of novel technologies and approaches inKursens lärandemål :

stem cell research and regenerative medicine. Students can demonstrate an interdisciplinary understanding of central concepts intissue engineering, biomaterials and stem cell science, and critically evaluate different methods and techniques used.

The course covers key aspects in stem cell research, ranging from fundamental mechanisms of cell functionKursens innehåll : and developmental processes to controlling cell behavior for tissue engineering. Emphasis will be on the use of biomaterials andengineering approaches to control the cellular microenvironment and steer stem cell differentiation, both for fundamentalunderstanding and in clinical translational applications. Networking with students and speakers is highly encouraged in this course.

The learning activities include lectures, workshops, seminars and discussions. Arbetsformer : Examination will take place in form of a poster session, in which the course participants will present their ownExamination :

research. The lectures, workshops and poster session are mandatory. Compensation according to the instructions ofObligatoriska moment :

the course director.15 - 20Antal studenter :

The selection is based on a comprehensive assessment based on the relevance of the course content for theirUrval av studenter : doctoral project and the personal motivation letter to attend the course.

The course is full time. The course venue is the seminar room A216 at CMB, entrance Berzelius v 35 formYtterligare information : the court yard of CMB. During October 3-4, the course participates in an international symposium on stem cell engineering andregenerative medicine organized at the Nobel Forum.


[email protected]

Kontaktpersoner : -

Title : Multi- and mega variate data analysis theory and practice in omics research




Basic knowledge in statistics, i.e. understanding of basic statistical concepts such as hypothesis testing, typeSärskild behörighet : I and type II error, power, significance, confidence interval, regression analysis and standard deviation is required.

Following successful completion of the course, students will have acquired a basic level of knowledgeKursens lärandemål : regarding multivariate analysis of large-scale datasets aquired in omics research. Students will be sufficiently proficient users to beable to apply learned methodologies in their own research projects. Specifically, students will: - Have basic understanding of theorybehind multivariate data analysis methods, principal component analysis (PCA), partial least squares (PLS), and orthogonalprojections to latent structures (OPLS). -Be able to normalize, filter, and scale Omics data prior to the analysis -Be able to use andinterpret PCA, PLS, and OPLS models in Omics studies -Be able to apply multivariate tools for putative biomarker identification -Beable to apply multivariate data analysis tools to detect outliers, trends, patterns and to classify groups within complex data -Be ableto relate multiple responses to multiple inputs using PLS modeling -Be able to interpret multivariate statistical models for scientificinsights -Have gained basic competence in how to use the SIMCA software for multivariate data analysis -Have basicunderstanding of multivariate design of experimental techinques -Be able to use acquired knowledge in multivariate data analysis ontheir own Omics data

Data sets in Omics research (e.g. genomics, transcriptomics, metabolomics, proteomics) contain manyKursens innehåll : hundreds or thousands of often quantitative variables, but only a handful of observations. The most important and interestingscientific findings can be found in a combination of the variables under study. Traditional statistics acquire knowledge about the databy analyzing one variable at time. This approach runs the risk of missing important interaction between several variables together.Multivariate data analysis (MVA) statistical methods, on the other hand, are able to include all the variables in the same analysisthereby giving opportunities to extract information from the complex data sets involved in Omics research. In this course thestudents will learn basic theoretical background behind multivariate statistical techniques such as principal component analysis(PCA), partial least squares regression analysis (PLS), and orthogonal projections to latent structures (OPLS). Furthermore, thestudents will learn to use SIMCA MVA software and train hands-on exercises in all the above mentioned techniques. In addition,participants will learn how to use state-of-the-art multivariate tools to extract putative biomarkers or other relevant findings in astatistically significant way. Opportunity will be given for the students to use the acquired knowledge in MVA to analyze their owndata sets, and answer their specific hypothesis with help of the instructor. Furthermore, design of experiments (DOE) will becovered. DOE is used for optimization of the effect of experimental variables, and thereby minimize time and resources spent in thelaboratory. The increased throughput and reliability of the experimental outcome will be demonstrated through hands-on analysis ofreal data using the software package MODDE.

Each day of the course is divided into a morning and an afternoon session. Every session will start with a theoreticalArbetsformer : lecture followed by practical, real-life exercises using the SIMCA or MODDE software. During the practical sessions, the studentswill have the possibility to work on their own data sets under guidance of the instructor to assure that the knowledge gained duringthe course will come into practical use in their own research.

The course examination will consist of a written report of a MVA analysis performed on the student¿s own data setsExamination : (if own data set not are available, they can be provided by the course instructor). The data set and choice of analysis method mustbe approved by the course instructor. The final report must be 3 A4 pages (12 point font, 2.5 cm margins) including references andmust be turned in within 2 weeks after completion of the course in order to receive course credits. The report should be based onacquired analysis skills in Simca software during the course. The report should consist of a discussion of the results in the light ofthe concepts covered during the course as well as in comparison to traditional analysis methods used in the relevant field ofresearch. In the event of an unsatisfactory report, as determined by the course organizer, the student will be given one additionalweek to re-write and resubmit the report. Attendance at all computer exercise sessions is required, as satisfactory completion of thecourse will also be assessed by completion and understanding of in-course computer exercises. In the case of necessary absence,the student will be required to perform the laboratory exercises outside of class before a passed grade is issued.

The course is composed of lectures, demonstrations and computer exercises using SIMCA-P+12 softwareObligatoriska moment : on real-life datasets, which will illustrate the principles and practice of MVA. The focus will thus be on practical applications anddevelopment of software skills, and attendance at all computer laboratory sessions is mandatory. The students will have to bringtheir own laptop for the computer exercises. The software package will be provided.

6 - 15Antal studenter : This is an introductory course. Therefore, little or no prior knowledge in multivariate data analysis is required.Urval av studenter :

However, familiarity of one or several Omics analysis methods is a merit. If the number of applicants exceeds the number of seats inthe course, the selection of course participants will be based on the motivation that the applicant hands in at the time of application.

Department of Medical Epidemiology and Biostatistics Karolinska Institutet Nobels väg 12 A Lecture hallYtterligare information : N4 171 77 Stockholm One of the leading scientists within the field of multivariate data analysis, prof Johan Gottfries, is invited togive a lecture. The course will be held every day from 09:00-17:00 with lunch breaks at 12:00.

Kursansvarig : Sanela KurtovicInstitutionen för medicin, Solna

[email protected]

Kontaktpersoner : -

Title : Brain development and Neurodevelopmental disorders




Background in medicine, biomedicine, neuroscience or psychology.Särskild behörighet : The aim of this translational neuroscience course is to provide an overview on the emerging field ofKursens lärandemål :

developmental cognitive neuroscience. In particular, we will focus on cortical brain development, development of cognitive functionsin typically developing children and children with neurodevelopmental disorders e.g., Attention-Deficit /Hyperactivity Disorder(ADHD) and Autism Spectrum Disorders (ASD), and the role of both genetic and environmental factors in the etiology of thesedisorders. During the course, students will learn to critically evaluate and explain in presentations the content of original articles.After the course students should be able to: 1) Describe fundamental neurodevelopmental processes (e.g. neurogenesis, neuronalmigration, synaptogenesis). 2) Describe genetic and molecular mechanisms controlling cortical development. 3) Describe cognitivedeficits among neurodevelopmental disorders (e.g., ADHD and ASD). 4) Postulate potential genetic /molecular mechanismsunderlying cognitive deficits in children with neurodevelopmental disorders

Course Curriculum Part I: Fundamentals of Developmental Neurobiology 1. Early brain development,Kursens innehåll : construction of neural circuits, and modification of neural circuits as a result of experience 2. Genetic control of cortical development 3. Effects of sex hormones on brain development Part II: Functional Brain development in humans 1. Age-Related Changes inexecutive function (e.g., working memory) 2. Working memory, and training induced plasticity 3. The molecular genetics ofexecutive function Part III: Neurodevelopmental Aspects of Clinical Disorders 1. The neurobiology and genetics of ADHD 2.Advances in the Cognitive Neuroscience of ASD 3. Childhood psychiatric disorders as anomalies in neurodevelopmental trajectories

A variety of teaching and learning strategies are presented during the course to facilitate students learning. TheseArbetsformer : strategies include short lectures, small group discussions, computer-based learning, and problem based learning.

The examination will consist of an oral group presentation focusing on cognitive deficits found in children withExamination : neurodevelopmental disorders (e.g. ADHD and ASD) and the potential genetic / molecular mechanisms underlying these deficits. Atthe beginning of the course, students will be assigned into different working group themes e.g., ADHD and ASD. These groups willwork together throughout the course and prepare for the final oral presentation. During the course there will also be formativeassessments to give students immediate feedback about their learning process during the different milestones of the course andclarify any questions relating to the final assessment. Course grades Pass: Students demonstrate an understanding of braindevelopment and cognitive deficits found in neuro-developmental disorders, and can postulate/hypothesize potential genetic /molecular mechanisms underlying these deficits based upon findings from both basic and clinical literature.

All lectures and seminars are mandatory. In order to make up for absence of a particular lecture, theObligatoriska moment : students will be required to read specific chapters from the recommended literature and write a short report.

10 - 14Antal studenter : The selection of the participants will be based upon their motivation letter.Urval av studenter :

This course is part of the Series of FRONTIERS IN NEUROSCIENCE COURSES The course is givenYtterligare information : Monday through Friday Time: 09:00--17:00

Kursansvarig : Rochellys HeijtzInstitutionen för [email protected]

Retzius Väg 8

17177Stockholm

Kontaktpersoner : -

Title : Advanced topics in genome biology




Särskild behörighet : After the completed course, the participants will be be able to understand and critically examine the contentKursens lärandemål :

and relevance of advanced scientific publications in the subject (genome biology). The students can demonstrate a capability ofdiscussing and evaluating scientific work of others. The students can demonstrate knowledge in genome biology, analyze and relatechromosome structure and function and the regulation of the transcriptome and critically evaluate different methods and techniquesused in genome biology.

The course includes an introduction lecture on the analysis of scientific publications chosen for the course andKursens innehåll : scientific seminars by some of the authors of the publications chosen for the course. The course contains analysis and discussionsof ground-breaking papers in the fields of gene regulation and structural maintenance of chromosome biology. Every student studies2-3 papers individually, and the papers are then discussed during weekly 2 hours sessions. The course provide time for studies ofinteresting papers, deepened understanding of the topics for the course as well enriching discussions.

The course contains a limited number of lectures and a few research seminars. The major pedagogic modes areArbetsformer : individual studies and discussions.

Examination based on the active participation and the proven understanding of the material during the weeklyExamination : discussions. In addition, every participant must submit a short report or reflection (1-2 pages), containing an introduction to their ownresearch project, explain how the course content connects to this and how the results of the course can be applied in their ownresearch.

The introduction lecture, seminars and weekly discussions are obligatory. Absence from discussions isObligatoriska moment : compensated according to the instructions of the course director.

8 - 12Antal studenter : The selection is based on a comprehensive assessment based on the relevance of the course content for theirUrval av studenter :

PhD project and the personal motivation letter to attend the course.The course takes place at CMB, KI.Ytterligare information :


[email protected]

Kontaktpersoner : -

Title : Mechanisms of Gene Regulation in Metabolism



ForskarnivåNivå : Department of Physiology and PharmacologyKursansvarig institution :

Särskild behörighet : At the end of the course students will understand and be able to discuss the different mechanisms thatKursens lärandemål :

regulate gene expression. They will be able to describe how these processes can affect metabolic disease and disease progression.The students will be able to choose the most appropriate methodologies to study diverse aspects of gene regulation in metabolism.

This course aims at giving students an overview of the current understanding of how metabolism and metabolicKursens innehåll : dysfunction are controlled at the level of gene regulation. During one week, students will focus on the genetic and epigeneticmechanisms that affect transcriptional output in diverse organs and tissues in health and disease situations. This will include: basicmechanisms of gene transcription, transcription factors and coregulators, mRNA splicing and genetic variability, the chromatinlandscape and associated DNA and histone modifications, noncoding RNAs and regulation of gene expression. Attention will begiven to single gene analysis as well as global regulation of gene expression. In each module the student will be introduced to thebasic concepts in the field and analyze situations in which dysregulation of the processes under examination leads to metabolicdisease. Each module will include a chapter dedicated to the presentation and discussion of current experimental approachesrelevant to research in that particular field of science.

This course will consist mainly of lectures and group discussions covering both theoretical and practical questionsArbetsformer : related to the different areas of gene regulation and metabolism. Some sessions will be dedicated to problem solving andpresentation of state-of-the-art methodologies relevant to research in each field.

Examination will consist of an oral presentation in which students discuss an example of metabolic disorder causedExamination : by dysregulation of gene expression and propose a research plan to further study that problem. The research plan should includeappropriate methodology learned during the course.

Presence at lectures, group work, and final presentation and discussion is mandatory. To compensate forObligatoriska moment : absence a written essay on the missed topic must be performed.

10 - 25Antal studenter : If the number of applicants exceeds the number of available places, applicants will be chosen by theUrval av studenter :

motivation letter supporting their application. Priority will be given to PhD students at the beginning of their training.The course will be held at the Solna Campus for one week, full time. Lectures will be given by invitedYtterligare information :

specialists who will address theoretical as well as methodological considerations in each field.

Kursansvarig : Jorge RuasInstitutionen för Fysiologi och Farmakologi(08)[email protected]

von Eulers väg 8

17177Stockholm

Kontaktpersoner : -

Title : Basic Course in Medical Statistics - a distance course







The course will be a distance course by using the platform Pingpong. The course contains videolectures, exercisesArbetsformer : with suggested solutions and 2 statistical software demonstration videos - Statistica and SPSS. The first and last day of the coursewill be face-to-face with an introduction the first day and seminars and group discussions the last day. In addition to the differentvideomoments the time will be spent working on computer based exercises and reading the course literature.

Course requirements: - Correct answers on the computer based exercises. - Active participation in the seminars. Examination : Attendance is mandatory for the seminars on the last day of the course. If the student is absent, he or sheObligatoriska moment :

can compensate the absence by handing in written answers to questions concerning the compulsory moments.35 - 40Antal studenter :


The course will be a distance course by using the platform Pingpong. The course contains videolectures,Ytterligare information : exercises with suggested solutions and 2 statistical software demonstration videos - Statistica and SPSS. The first and last day ofthe course will be face-to-face with an introduction the first day and seminars and group discussions the last day. In addition to thedifferent videomoments the time will be spent working on computer based exercises and reading the course literature.


[email protected]


Title : Basic Course in Medical Statistics - a distance course







The course will be a distance course by using the platform Pingpong. The course contains videolectures, exercisesArbetsformer : with suggested solutions and 2 statistical software demonstration videos - Statistica and SPSS. The first and last day of the coursewill be face-to-face with an introduction the first day and seminars and group discussions the last day. In addition to the differentvideomoments the time will be spent working on computer based exercises and reading the course literature.

Course requirements: - Correct answers on the computer based exercises. - Active participation in the seminars. Examination : Attendance is mandatory for the seminars on the last day of the course. If the student is absent, he or sheObligatoriska moment :

can compensate the absence by handing in written answers to questions concerning the compulsory moments.35 - 40Antal studenter :


The course will be a distance course by using the platform Pingpong. The course contains videolectures,Ytterligare information : exercises with suggested solutions and 2 statistical software demonstration videos - Statistica and SPSS. The first and last day ofthe course will be face-to-face with an introduction the first day and seminars and group discussions the last day. In addition to thedifferent videomoments the time will be spent working on computer based exercises and reading the course literature.


[email protected]


Title : Early drug discovery in the cancer field




Särskild behörighet : The intended learning outcome of this course is for the students to be able to evaluate cutting edge researchKursens lärandemål :

activities within the fields of oncology focusing on the process of discovering anticancer agents. The course is organized toencourage analytical and critical thinking. At the end of this course, students should be able to understand, analyse and criticisecurrent strategies towards exploiting the available information on cell cycle regulation, tumour suppressors and oncogenes for thedevelopment of novel therapeutics. In this way the student should be able to develop a proposal for a drug discovery strategy in thecancer field. They should also evaluate the relevance of the topics presented for their future research activities and PhD studies.

The course is organised to contain approximately 25 hours of lectures, held by invited national and internationalKursens innehåll : prominent researchers in the cancer and drug discovery fields, as well as 10 hours of discussion and student activities. Thespeakers will be asked to organise their talks to give a comprehensive and pedagogical overview of the research area as well as anin depth discussion on their own research. Each seminar will be followed by a discussion led by the course organisers where thestudents are encouraged to interact with the invited speaker. To enable a fruitful discussion the students will be asked to readrelevant literature in the field. The topic presented will cover the main aspects of: 1. Drug discovery strategies 2. Mitotic targets andcancer 3. Targeting angiogenesis in cancer 4. Targeting the p53 pathway 5. Targeting myc functions 6. Targeting proteindegradation 7. Targeting kinases 8. Targeting deacetylases 5. Technological advances for the discovery and characterisation ofanticancer therapeutics.

The course is full-time and lasts for 1 week. It will consist of approximately of 5 hours of lectures/day. Each lectureArbetsformer : will be followed by a discussion led by one of the course organisers. To increase the learning process and to stimulate the reflectionon the seminars, the students will be asked to study the most recent literature, still not present in the text books within the presentedfields. In addition we will perform several group exercises where students propose protocols for drug discovery based on thereceived information. The advantages and disadvantages of each strategy proposal will be discussed by all participants.

For assessment, the student will answer 5 questions as well as propose an original drug discovery strategy in theExamination : format of a grant application. These five questions are at levels 3 to 5 (that is "multi structural", "relational" and ¿extended abstract")in the SOLO taxonomy classification.

Students are expected to attend all lectures and presentations and provide a written essay. In the case ofObligatoriska moment : absence, the student will be asked to read a relevant review article on the topic missed, summarise it and discuss it with theorganiser of the course at a convenient time by appointment.

10 - 20Antal studenter : Students should have an interest in pursuing further studies during their career related with the topic of theUrval av studenter :

course such as the study of the molecular mechanisms governing cell cycle and the onset of cancer, chemical biology and theexploitation of this knowledge to discover and understand in detail the mechanism of action of therapeutic compounds.

The 2011 course will include lectures by the following internationally recognised experts in specific fieldsYtterligare information : within the area of cancer therapeutics. Amongst them we have invited Prof Sir David Lane (University of Dundee, Scotland),discoverer of the tumour suppressor p53 in 1979, with a remarkable international track record and career with more than 200publications on the p53 topic.

Kursansvarig : Sonia LainInstitutionen för mikrobiologi, tumör- och cellbiologi

[email protected]

Nobels väg 16

S-171 77 Stockholm

Kontaktpersoner : Klas WimanEj satt

[email protected]

Title : Clinical research in practice




None. Särskild behörighet : After completion of the course the students should be able to: 1) Evaluate potential methodological issues orKursens lärandemål :

opportunities in clinical research and critically analyse and argue both the pros and cons of the various methodologies used. 2)Independently plan and produce a grant application draft including a thorough methodological evaluation. 3) Critically reflect onother students¿ individual project work in a scientifically constructive way. 4) Interpret and critically evaluate scientific studiesrelevant to the course content.

The course is designed for PhD-students, in particular those who are at an early stage of their researchKursens innehåll : education, and those with an interest in conducting clinical research. The content of the course is as follows: 1) The beginning -Introducing the importance of study protocols and issues relating to funding, 2) Next steps - Ethical applications and statistical powercalculations, 3) Opportunities and pitfalls in observational clinical research, 4) Use of questionnaires in clinical research andopportunities and pitfalls in running a clinical trial, 5) The end result - How to write a scientific article, 6) Examination and courseevaluation. Throughout the course, the students will work on an individual project (examination 1) for peer-review (examination 2).Further, students will critically review and discuss relevant scientific articles (examination 3).

Lectures, individual article review, group discussions and homework tasks will be used. The course focuses onArbetsformer : active learning, i.e. putting knowledge into practice and critically reflecting upon the knowledge, rather than memorising facts.Therefore, much of the focus of the course is on the individual project where students are required to develop a grant applicationdraft including several important aspects covered in the lectures, article reviews and group discussions. Students will alsopeer-review each other¿s projects and this will form the basis for the final examination seminar.

To pass the course the student must actively participate in the course and pass the examinations: 1) IndividualExamination : project work: To develop a written comprehensive yet concise grant application draft including several important aspects of clinicalresearch in practice as discussed during the course; 2) Peer-review of other students¿ projects followed by oral presentation ofpeer-reviewed projects in group discussions at the end of the course; 3) Critically review scientific articles relevant to the coursecontent and participate actively in the group discussions.

Compulsory attendance includes the scheduled lectures and group discussions. Absence will need to beObligatoriska moment : replaced by individual assignments following discussion with the course co-ordinator, e.g. article reviews, with written or oralfollow-up.

12 - 16Antal studenter : Preference will be given to students early on in their PhD education, who have a clinical research focus, whereUrval av studenter :

the benefits of this course will be greatest. Date of registration as a PhD student will be used in the selection process. The course will run on Friday afternoons 14.00-16.15 at Norra Stationsgatan 67. Lecturers areYtterligare information :

researchers active in the Unit of Upper Gastrointestinal Research, directed by Professor Jesper Lagergren. The course is targeted atPhD students with an interest in the process of clinical research in practice. Emphasis is on the application of knowledge gainedduring the course to the students own research and planned studies. Students who have completed the PhD course "Study Designin Clinical Research" (number 1794) might benefit especially from attending this course.

Kursansvarig : Anna WikmanInstitutionen för molekylär medicin och [email protected]

Norra Stationsgatan 67, vån 2

17176Stockholm

Kontaktpersoner : Margrete GellervikInstitutionen för molekylär medicin och kirurgi

[email protected]

Title : Pediatric Oncology Research




Särskild behörighet : Describe the basic themes for childhood cancer research such as epidemiology, register research, tumorKursens lärandemål :

biology and genetics, side effects, late effects and follow up. Discuss the ethical issues around childhood cancer research. Describeand understand the principles of treatment, existing therapies, new targeted therapies and personalized medicine. Explain andtheorize about the link between tumor biology/genetics, and drug treatments - current and development of new targeted drugs. Understand and discuss research models in pediatric oncology research. Critical comment on research findings regarding pediatriconcology research.

Introduction to research on pediatric oncology for PhD students and junior postdocs, with research projects inKursens innehåll : this specific area or in an adjacent area. Presentation and discussion about problems, possibilities, and research models that arespecific for the research area of pediatric oncology. General introduction and focus on five themes specific for pediatric oncology,namely ethics, epidemiology, tumor biology and genetics, existing and novel targeted drug treatments, and side effects, late effectsand follow up.

Lectures, seminaries, group exercises with supervised discussions. One-day research symposium. Arbetsformer : Oral and written individual examination. Written reports from group work, oral reports and discussions. Examination :

The entire course is compulsory. In case of absence, compensation tasks will be handed out.Obligatoriska moment : 15 - 30Antal studenter :

Priority will be given to doctoral students with projects concerning pediatric oncology research.Urval av studenter : The course starts Monday afternoon and goes on Tuesday, Wednesday and Thursday with full days withYtterligare information :

lectures and seminaries. Lecturers will be Klas Blomgren, Mats Heyman, John Inge Johnsen and Per Kogner among others. Thecourse ends with a symposium on Friday with internationally known speakers. The course will be held at CCK, KI Solna.

Kursansvarig : Malin WickströmInstitutionen för kvinnors och barns hä[email protected]

Kontaktpersoner : -

Title : Mesenchymal stem cells and sarcoma. From biology to clinicalmanagement.




Särskild behörighet : After completing the course the participants should: Be able to account for the biology of normal andKursens lärandemål :

malignant mesenchymal cells. Get insight into the genetics, diagnostics, pathology and treatment of mesenchymal tumors. Haveacquired a deeper understanding of the sarcoma clinical management by meeting the patient and the treating team. Have acquiredan insight into the challenges of the clinical management of patients affected. Be able to account for novel potential therapies forsarcoma and ongoing clinical trials.

The following topics will be covered: Biology of the normal mesenchymal cell. Epidemiology, pathology, geneticKursens innehåll : hallmarks and oncogenic pathways of sarcoma tumors. The sarcoma progenitor cell. Animal models of sarcoma. Radiologicalhistopathological and molecular diagnosis with practical demonstrations. Treatment: Surgery, Radiation, Chemotherapy. Targetedtherapy: GIST as a model. Emerging targeted therapies. The sarcoma patient.

The course will include daily lectures will be held by experts in different sarcoma topics combined with meetings withArbetsformer : the sarcoma treating team (Sarcoma Center Karolinska). This include: Visits to the pathology, surgery, and oncology departments.Participation in multidisciplinary clinical conference. Meeting the patient.

Individual written examination, according to the intended learning outcome.Examination : Presence at the clinical demonstrations is obligatory and cannot be compensated for.Obligatoriska moment :

10 - 20Antal studenter : Priority will be given to PhD students with research project in the field of mesenchymal stem cells and/orUrval av studenter :

sarcoma. Selection will be done from the written motivation.Ytterligare information :

Kursansvarig : Bertha BrodinInstitutionen för [email protected]

Cancer Centrum Karolinska CCK R8:00

171 76Stockholm

Kontaktpersoner : Robert BranstromInstitutionen för onkologi-patologi

[email protected]

Bertha BrodinInstitutionen för [email protected]

Cancer Centrum Karolinska CCK R8:00

171 76Stockholm

Title : Frontiers in Cogntive Neuroscience




180 hp in medicine, biomedicine, biology, psychology, or cognitive science, or master degree in medicalSärskild behörighet : imaging engineering

After the course the student must be able to: (1) account for current concepts and key principles of cognitiveKursens lärandemål : neuroscience; (2) show an understanding of the inter-disiplinary nature of cognitive neuroscience with its roots in both psychologyand neuroscience; (3) discuss and critically evaluate scientific articles in the field; (4) To show basic knowledge about the strengthsand weakness of the different state-of-the-art methods used in cognitive neuroscience.

(1) Series of lectures informing about the state of art knowledge about: (i) Perception and sensory mechanisms;Kursens innehåll : (ii) action planning and execution (iii); (iv) sex differences in the brain; (v) higher cognitive functions including working memory andcreativity; (vi) memory; and (vii) cognitive effects of aging (2) Seminars where the students will critically discuss key publishedpapers, and group presentations where they will present their analyses and conclusions for the whole group.

Lectures, seminars, and group presentations.Arbetsformer : The oral presentation and group discussions during the last day¿s seminar count as examination. We will assessExamination :

individual students¿ ability to discuss and reason about current issues and problems in cognitive neuroscience. The group seminar is obligatory. In addition to that, the students are assumed to take part in the lectures.Obligatoriska moment :

The student will be able to compensate missing attendance by submitting written reports on the missed material later.5 - 14Antal studenter :

The primary selection criteria are 1) the usefulness of the course for the graduate student in his/her graduateUrval av studenter : work, and 2) the motivation given in the application to the course.

This course is part of the Series of FRONTIERS IN NEUROSCIENCE COURSES. Ytterligare information :

Kursansvarig : Henrik EhrssonInstitutionen för [email protected]

Retzius väg 8

17177 Stockholm

Kontaktpersoner : -

Title : Social and life course epidemiology



ForskarnivåNivå : Department of Public Health SciencesKursansvarig institution :

Ingen särskild behörighetSärskild behörighet : Intended learning outcomes Knowledge and understanding At the end of the course the doctoral studentKursens lärandemål :

should be able to: 1. Describe the design of cohort studies. and other common designs in life course epidemiology 2. Describe thefundamental features of social and life course determinants of health. 3. Describe validity, and pros and cons of different indicatorsof socioeconomic position (SEP) in studies of social and life course determinants of health. 4. Describe how social environment atdifferent time points over the life course, may influence long-term health and risk of disease directly or indirectly through otherdeterminants, e.g. growth in fetal life and childhood, cognitive ability, health behaviors, psychosocial mechanisms or social capital. 5. Describe how disease risk can be transmitted between generations through genetic, epigenetic, social and behavioralmechanisms. Proficiency and aptitude At the end of the course the doctoral student should be able to reason and argue aboutdesign and methodological problems in studies of social determinants of health in general and life course epidemiological studies inparticular. Ability to assess and approach At the end of the course the doctoral student should be able to discuss and reason aboutthe complex research ethical questions related to large scale and long-term longitudinal health research.

Course content 1) Overview and discussion of concepts and theories related to SEP, social causation, lifeKursens innehåll : course and intergenerational determinants of health. 2) Overview and discussion of strength and weaknesses of epidemiologicalstudy designs most commonly used in life course research. The below topics are will be discussed: a. Major public health problemsand their life course etiology: circulatory disease, diabetes, obesity, cancer, and mental diseases. b. Design and interpretation ofcausality in life course epidemiological studies. c. Intergenerational studies related to SEP, growth in fetal life and childhood,cognitive ability and health in later life. d. Life course studies in the Nordic countries, Europe and other countries. e. Ethical issues inlarge and long-term longitudinal health research.

Teaching forms The teaching will be based on lectures, small group tutorials and discussions, and critical reviews ofArbetsformer : literature. The course participants will read, discuss and present selected scientific papers and other relevant literature.

Examination The course will be examined through the student's active and substantial participation in critical reviewsExamination : of scientific papers and presentations. Absence from a seminar and group activity might be compensated by a written assignment.

Course requirements The following are the requirements for successful completion of the course: 1)Obligatoriska moment : Participate actively in lectures, seminars and group activities. 2) Prepare and orally present a critical review of a scientific paper. 3)Read literature selected for seminars and take active part in the discussions. 4) Give substantial feedback to student fellows on theircritical reviews and presentations.

15 - 25Antal studenter : Participants will be selected based on the relevance of the course syllabus to their doctoral project. IfUrval av studenter :

necessary, further selection criteria based on each participant¿s date of registration for doctoral studies will be used.The course is part of the programme in Public Health Science.Ytterligare information :

Kursansvarig : Finn RasmussenInstitutionen för folkhä[email protected]

Karolinska Institutet, Norrbacka

171 76Stockholm

Kontaktpersoner : -

Title : Write your research results and get them published




None.Särskild behörighet : The overall aim of the course is to give the phd student basic knowledge in presenting research results inKursens lärandemål :

different written presentation forms: scientific paper, abstract, case report, letter to editor, review paper, popular science paper,press release, poster, and electronic poster. After attending the course, the Ph.D. student should: * know the characteristics anddisposition of different written presentation forms and when to use them: scientific paper, abstract, case report, letter to editor,review paper, popular science paper, press release, poster, and electronic poster * understand and be able to apply the terminologyassociated to scientific writing, eg impact factor, running title, capsule, abstract, key words, acknowledgements, references * be ableto desig a scientific poster and an electronic poster * be able to write an abstract * be able to compose a draft for a research paper *be able to produce a draft for a popular science paper * be able to dispose and edit a scientific paper according to the editorialrequirements set by different journals * be able to compile and summarize information aligned to the target group for scientific aswell as popular science papers * be able to identify the main scope and focus of your research and choose what is the most relevantand interesting for your target audience * have learnt the basics of EndNote software for references * be able to organize and applybasic rethorics in written form * have basic knowledge of what sources of scientific texts should (and should not) be used in order toinclude reliable and relevant information as references for your written work * be able to reflect upon, document and present yourdevelopment as a writer of scientific texts during the course

The scope of this course is how to write about your research results in differents contexts. The main content ofKursens innehåll : the course: - characteristics and disposition of different written presentation forms: scientific paper, abstract, case report, letter toeditor, review paper, popular science paper, press release, poster, and electronic poster - terminology associated to scientificwriting, eg impact factor, running title, capsule, abstract, key words, acknowledgements, references - designing and writing a poster,an electronic poster, an abstract, a draft for a research paper, and a popular science paper - editorial requirements of differentjournals - summarizing information aiming at the target audience - identifying the main scope of your research - basics of EndNotesoftware - basic rethorics in written form - reference sources for your written work

Lectures, seminares, writing exercises, group assignments and practical exercises. As part of the learning process,Arbetsformer : the Ph.D students will be members of in-class review groups, giving feed-back to their colleagues.

1) The Ph.D student writes a log book in order to follow up and reflect upon the development of his/her own skills 2)Examination : Written assignments reflecting the learning goals of the course: draft for scientific and popular science paper, poster, electronicposter, and abstract.

Lectures, seminares and group assignments as well as all written assignments. Absence can beObligatoriska moment : compensated: a) during next years course b) individual assigments

10 - 15Antal studenter : 1) personal motivation 2) priority will be given to recently registered phd students, who have not yet submittedUrval av studenter :

a manuscript Please note that this course is best suitable for phd students who have not yet submitted a manuscriptYtterligare information :

and/or are at an early stage of their research education. In order to participate in the course, you need to have a research plan andsome preliminary research results to work with during the writing assignments. Main lecturers: Lalit Kumar, phd, senior researcherand supervisor at Karolinska Institutet, author of a great number of scientific papers. Jenny Eklund: journalist with many years ofexperience in writing and lecturing on different topics related to the writing process and personal development, author of a number ofarticles and books The course will take place at Karolinska Hospital, Solna and Karolinska Institutet, Solna. Please address ALLQUESTIONS to: Anna Hildenbrand Wachtmeister, [email protected] or cellphone 070-789 06 07


Kontaktpersoner : Anna HildenbrandInstitutionen för kvinnors och barns hä[email protected]

Lalit KumarInstitutionen för kvinnors och barns hälsa

[email protected]

Title : Skriv och publicera dina forskningsresultat




Inga särskilda förkunskaper krävs.Särskild behörighet : Kursens övergripande lärandemål är att ge doktoranden grundläggande kunskaper i att presenteraKursens lärandemål :

forskningsresultat i skriftlig form: vetenskaplig artikel, abstract, case report, letter to editor, review-artikel, populärvetenskaplig artikel,press-release, poster och elektronisk poster. Efter genomgången kurs ska doktoranden: - känna till karaktäristika och disposition avolika skriftliga presentationsformer och när de används: vetenskaplig och populärvetenskaplig artikel, abstract, case reports, letter toeditor, review-artikel, press-release, poster och elektronisk poster - ha förståelse för och förmåga att använda terminologi associeradtill vetenskapligt skrivande, exempelvis impact factor, running title, capsule, abstract, key words, acknowledgements, references -kunna designa en vetenskaplig poster och en elektronisk poster - kunna skriva ett abstract - kunna sammanställa ett utkast för ettvetenskapligt manuskript - kunna skriva ett utkast för en populärvetenskaplig artikel - kunna disponera och redigera ettvetenskapligt manuskript i enlighet med olika tidskrifters "editorial requirements" - kunna sammanfatta och sammanställainformation för att passa målgruppen för det vetenskapliga och populärvetenskapliga skrivandet - kunna identifiera huvudfokus förhans/hennes forskning för att göra texten relevant och intressant för målgruppen - kunna grunderna i EndNote för att skapa ochredigera referenslistor - kunna organisera och använda enkel retorik i skriven form - grundläggande kunskap om vilka källor sombör (och inte bör) användas som referenser för vetenskapligt skrivande för att garantera tillförlitlig och relevant information - kunnareflektera kring, dokumentera och presentera sin utveckling som skribent av vetenskapliga texter under kursen

Kursens huvudsakliga innehåll är hur man presenterar forskningsresultat i skriftlig form i olika sammanhang: -Kursens innehåll : karaktäristika och disposition av olika skriftliga presentationsformer: vetenskaplig och populärvetenskaplig artikel, abstract, casereport, letter to editor, review paper, popular science paper, press-release, poster och elektronisk poster - terminologi associerad tillvetenskapligt skrivande, exempelvis: impact factor, running title, capsule, abstract, key words, acknowledgements, references -design och skrivande av poster, elektronisk poster, abstract, utkast för en vetenskaplig och populärvetenskaplig artikel - olikatidskrifters 'editorial requirements' - sammanställande och sammanfattande av information anpassad för målgruppen - identifikationav forskningens huvudinnehåll och fokus - grunderna i användande av EndNote för referenshantering - basal retorik i skriftlig form - referenser för skriftligt arbete

Föreläsningar, seminarier, skrivövningar, grupparbeten och praktiska övningar. Som del av lärprocessen kommerArbetsformer : doktoranderna att ingå i review-grupper för att ge feed-back till kurskollegorna.

1) Doktoranden för en loggbok för att följa utvecklingen av de färdigheter som förmedlas under kursen. 2) SkriftligExamination : inlämningsuppgift som reflekterar lärandemålen: vetenskaplig och populärvetenskaplig artikel, abstract, poster och elektronisk poster

Obligatoriska moment omfattar föreläsningar, seminarier och grupparbeten samt alla skriftligaObligatoriska moment : inlämningsuppgifter. Frånvaro kan, efter överenskommelse med kursledningen, kompenseras med motsvarande avsnitt under nästatermins kurs alternativt med individuella inlämningsuppgifter.

10 - 15Antal studenter : 1) personlig motivering 2) prioritet ges till nyregistrerade doktorander som ännu inte har publicerat någonUrval av studenter :

vetenskaplig artikel och / eller befinner sig i början av sina forskarstudierKursen vänder sig i första hand till nyantagna doktorander som ännu inte har publicerat någonYtterligare information :

vetenskaplig artikel och / eller befinner sig i början av sin forskarutbildning. För att på ett meningsfullt sätt kunna delta i kursenbehöver du ha en forskarplan och några preliminära forskningsresultat att använda i skrivövningarna. Om du har några frågor,kontakta ENDAST Anna Hildenbrand Wachtmeister, [email protected] (070-7890607) Huvudföreläsare: LalitKumar, phd, är senior researcher och handlare för doktorander vid Karolinska Institutet. Han är författare till ett stort antalvetenskapliga artiklar och har stor erfarenhet av skrivande, planeringa av forskningsprojekt och handledning. Jenny Eklund ärjournalist med mångårig erfarenhet av skrivande och undervisning inom områden relaterade till skrivprocessen och personligutveckling. Hon är författare till ett stort antal artiklar och även böcker.




[email protected]

Title : Laboratory Techniques and Analysis of Results - Orientation course




None.Särskild behörighet : After attending the course, the PhD student who was not previously familiar with modern laboratoryKursens lärandemål :

techniques should * understand the basic principle and the theory behind the mehtods used and have hands on experience in celland molecular biology tools used in the lab; both classical and advanced current methods * be able to critically analyse the resultsand interpret the results from the techniques covered by the course * be able to apply the techniques in own research project.

The basic principles and the theory with trouble shootings of Molecular biology techniques such asKursens innehåll : Immunohistochemsitry, RNA extraction, Real time PCR, microarray, Advanced and latest Bioinformatics tools in molecular networkanalysis (IPA software), stem cell isolation and mono layer cell culture, advanced 3 Dimensional cell culture will be covered duringthe lectures and the same will be demonstrated to the students and they will have hands on training.

1. The course will have 4 hrs of lectures /day (a total of 36 h) covering the basic principles, theory, and analysis andArbetsformer : interpreting the results every day. 2. Hands on training on the laboratory methods 4 hrs/day (a total of 36 h) 3. Study the theory,discuss application for the techniques and problem based discussions (a total of 40 h) 4. Examination covering practical andtheoretical understanding gained (8 h)

Basic understanding will be tested with MCQs and in-depth knowledge written examination. Examination : All lectures and laboratory techniques sessions. Absence can be compensated during next years courseObligatoriska moment :

or with individual assignments in agreement with the contact persons for the course.5 - 10Antal studenter :

1) Relevant research project - priority is given to students who need this course for their research projects 2)Urval av studenter : Personal motivation

The course will be conducted at the Karolinska Universityhospital, Solna. Please ADDRESS ALLYtterligare information : QUESTIONS TO Anna Hildenbrand Wachtmeister, [email protected] (cell phone: 070-789 06 07)




[email protected]

Title : Scientific visualization and presentation in 3D




Särskild behörighet : After the course the students should: ...have obtained a basic knowledge of how 3D software packages canKursens lärandemål :

be used to aid in the presentation of biomedical research results and biological phenomenon and mechanisms. ...understand how3D models are generated, stored and used to make renders and animations. ...have acquired enough skills with the softwarepackage Autodesk Maya to be able to generate renders and animations of cells, viruses, proteins and DNA to make good lookinganimations and figures for posters, articles and oral presentations. ...have acquired enough skills with the software package AdobeAfter Effects to be able to put together and composit a final movie file from rendered frames. ...have aquired enough skills with thesoftware package Adobe Illustrator to integrate 3D renders from Autodesk Maya with vector drawings to produce figures for scientificposters, papers and oral presentations. ...have acquired the ability to evaluate how biological animations and 3D figures producedby other people could be reproduced by themselves. ...have acquired the ability to evaluate how much time and effort it wouldrequire to take an idea or sketch of a biological mechanism and from that, produce a finalized high quality 3D render or animation.

The course will contain lectures, demos, supervised exercises and home assignments that will aim to explainKursens innehåll : how to build computer 3D models of cells, viruses, proteins and DNA and how to use these computer models to generate animationsand figures describing biological phenomena. The lectures and exercises will focus on teaching the students how to use thesoftware package Autodesk Maya for these purposes. Towards the end of the course, the students will be encouraged to buildmodels and animations that relate to their own research.

A series of 6 half-day sessions spread out over 3 weeks. The sessions will combine lectures with demonstrations ofArbetsformer : software and individual supervised exercises in a computer lab. Between sessions, students are required to complete homeassignments.

Examination will be performed by 5 home assignments, where each home assignment corresponds to about one dayExamination : of work for the student. The assignments will be designed so that they guide the student through the methods of reproducing the3D-models, animations, or renders that were the topics of the preceding classroom session. When choosing the subject of theirmodels, renders, e.t.c, the students are asked to refer to their own research for inspiration. This way, the students will haveproduced plenty of their own material at the end of the course that can be readily applied to make animations and presentationsabout their research.

Prescence is mandatory at at least 5 of the total 6 course sessions. In addition, any absence will need toObligatoriska moment : be compensated by the student who then has to complete additional home assignments with contents corresponding to the missedclasses.

5 - 13Antal studenter : In case of more applicants than seats, priority will be given to those applicants where the subject is ofUrval av studenter :

relevance for their research project, according to the written application motivations. Course will be given as 6 half day sessions with home assignments between classes. Ytterligare information :

Kursansvarig : Björn HögbergInstitutionen för [email protected]

Retzius väg 8

171 77Stockholm

Kontaktpersoner : -

Title : Klinisk forskning och Good Clinical Practice: protokoll, informeratsamtycke och ansökan i enlighet med lagar/regler



ForskarnivåNivå : Department of Clinical Sciences, Danderyd HospitalKursansvarig institution :

--Särskild behörighet : Kunskaper om Good Clinical Practice (GCP) samt forskningsetik (Helsingforsdeklarationen). Kursen täckerKursens lärandemål :

de krav på GCP-utbildning som Läkemedelsverkets ställer för att delta i en klinisk läkemedelsprövning. Deltagaren ska eftergenomgången kurs kunna delta som en prövare i en klinisk prövning. Kunskaper om hur man praktiskt ansöker om klinisk prövningtill Regional etikprövningsnämnd, Läkemedelsverket samt till Datainspektionen. Deltagaren ska efter genomgången kurs kunnaskriva en ansökan till Regional etikprövningsnämnd och veta hur man skriver sådan till Läkemedelsverket samt till Datainspektionen.Kunskaper rörande regelverket för klinisk prövning (Etikprövningslagen, Personuppgiftslagen, Biobankslagen, Läkemedelsverketsförfattningssamling m fl). Deltagaren ska efter genomgången kurs känna till regelverket för att rätt kunna planera en klinisk prövning.Beräkning av deltagarantalet i en studie. Deltagaren ska efter genomgången kurs veta vad som påverkar studiestorlek och kunna tafram rätt underlag för att kunna beräkna detta. Kunskap om kraven att registrera en studie i publik databas (Clinical Trial Registry)samt hur man gör för att få en studie publicerad. Deltagaren ska efter genomgången kurs kunna registrera en studie i en publikdatabas.

Föreläsningar om det regelverk som gäller vid kliniska prövningar; Helsingforsdeklarationen, GCP,Kursens innehåll : Etikprövningslagen, Personuppgiftslagen, Biobankslagen, Läkemedelsverket författningssamling m fl. Beräkning av patientantalGenomgång av ansökningshandlingar till Regional etikprövningsnämnd, Läkemedelsverket och Datainspektionen. Hur man skriveren etikansökan och författar en patientinformation. Hur man gör för att registrera en prövning i ett Clinical Trial Registry samt reglerför publicering. Praktiska GCP-råd på hur man genomför en klinisk prövning.

Föreläsningar samt examinationsuppgift (studiesynopsis, etikansökan och patientinformation).Arbetsformer : Doktorandens examinationsuppgift kommer att bedömas och diskuteras i seminarieform. Examination :

Närvaro vid undervisning/seminarier samt inlämning av examinationsuppgift (studiesynopsis, etikansökanObligatoriska moment : och patientinformation). Vid frånvaro från schemalagda aktiviteter måste deltagaren genom kompletterade extra inlämningsuppgiftkunna styrka motsvarande inhämtning av kunskap.

10 - 30Antal studenter : Sökande som för sitt forskningsprojekt bedöms ha störst behov av de kunskaper som förmedlas av kursen harUrval av studenter :

företräde. Sökandes motivation för att delta i kursen kan också bidra vid urval av de sökande. Kursen består av föreläsningar och arbete i seminarieform 2012-11-12--13 och 2012-11-23 på DanderydsYtterligare information :

sjukhus. Examinationsuppgiften (studiesynopsis, etikansökan och patientinformation) genomförs 2012-11-14--15 och lämnasdärefter in för individuell bedömning och återkoppling. Examinationsuppgiften kommer i seminarieform att bedömas och diskuteras2012-11-23.

Kursansvarig : Thomas KahanInstitutionen för kliniska vetenskaper, Danderyds sjukhus08 123 568 [email protected]

Kontaktpersoner : -

Title : Medfödda immunförsvars receptorer för detektion av aminosyror



ForskarnivåNivå : Department of Medicine, HuddingeKursansvarig institution :

Basics in immunology including the receptors of the innate immune system and virology. Overview of innateSärskild behörighet : immune receptors which can be gained from recent review articles.

By the end of the course students will be able to: 1. analyze papers in the literature regarding Nucleic AcidKursens lärandemål : Detection by the Immune System. 2. conduct critical analysis of contemporary research in Nucleic Acid Detection by the ImmuneSystem. 3. discuss essential concepts in Innate Immune Detection. 4. demonstrate proficient verbal communication skills that reflectscientific analysis of the literature (oral presentation), 5. demonstrate proficient scientific writing skills that reflect scientific analysis ofthe literature (scientific writing), and 6. design experiments that provide interpretable information.

Each session involves the discussion of two significant publications within the literature of Innate ImmuneKursens innehåll : Detection of Nucleic Acids. This is a recent developing field with impact on basic understanding of host-pathogen interactions as wellas associated/subsequent pathological outcomes. The Ten primary topics to be covered are: Recognition and Antiviral Signalingthrough TLRs Recognition and Antiviral Signaling through RLHs + NLRs, Early Cellular Responses to Nucleic Acids, Dendritic CellResponses to Nucleic Acids (mDC/pDC/etc), Macrophage / Monocyte Responses to Nucleic Acids, Non-hematopoetic cellresponses to Nucleic Acids, CpG responses, ssRNA and dsRNA responses, dsDNA responses, Nucleic acids in Autoimmunity.

Each session involves the discussion of two significant papers from the recent literature. The group discussion willArbetsformer : be guided by a team of two students from the course and a knowledgeable faculty discussant. The list of discussion papers will spanthe breadth of Innate Immune Detection of Nucleic Acids in host-defense and pathology. At the beginning of each class, onemember of each student team will give an introduction of 15 minutes (PowerPoint format), to present background material for thediscussion paper and to frame the problem being studied (field review). Next, the faculty discussant will project slides of the figuresfrom the paper, and will elicit discussion from all members of the class to evaluate the data. After the figures have been discussed,the second member of the student team will make a short 'perspectives' presentation of 15 minutes, in which the person discussesother approaches being used to study the problem, conflicting conclusions from other studies, etc. Finally, the faculty discussant willlead a discussion of 'next experiments', which students will already have proposed on documents that they submitted at thebeginning of class (1-2 pages). Every student in the class will be responsible for fully reading the paper to be discussed that dayprior to class, and should be prepared to discuss each figure. Also, each student must submit a 'next experiments' document whenarriving in class. A short review(s) related to the topic of the discussion paper will be provided on the reading list prior to class. Whenpossible, the topic will also be presented by an invited speaker working in the field after the student presentations. The course willrun for 5 weeks. 2 days a week for approx 4 hours. 3 hours of literature discussions and 1 hour of seminars by an invited speakerworking in the field. The ten topics will be covered by student pairs for 'presentation'. Each pair will present 2-3 times within the timethe course is held depending on attendence.

Presentations will be evaluated on content, organization and delivery, which should demonstrate accurateExamination : knowledge, clear understanding and ability to explain the significance, strengths and weaknesses of the research, and the ability tocommunicate in a clear and engaging manner. Student progress and reaching of the intended learning outcomes will be assessedon the basis of: 1. weekly 'next experiment' writing assignments 33% 2. evaluation of participation in discussion, and 33% 3.evaluation of the quality of scientific oral presentation 33% performed during the duration of the course.

Each course session involves the discussion of two significant publications within the literature of the fieldObligatoriska moment : of Innate immune detection of nucleic acids. Presentations, and 'next experiment' documents are mandatory to class participation.Oral participation in presentations and discussions of the literature are mandatory. Compensation for class absence can by done byindividual written reports on the literature and next experiment expanded from 1-2 pages up to >5 pages.

6 - 10Antal studenter : Student selections will be based on personal motivation related to their current research projects.Urval av studenter :

10 classes in the course are to be held on Mondays and Wednesdays from 9:15 to approx 11:30. CourseYtterligare information : is likely to be held at the Center for Infectious Medicine (CIM) at Huddinge. However, this may change if many of the studentsregularly work at Solna Campus.

Kursansvarig : Steven ApplequistInstitutionen för medicin, Huddinge585 [email protected]

Kontaktpersoner : -

Title : Brain circuits




Särskild behörighet : By the end of the course the student shall be able to: Explain the structure and function of the main neuronalKursens lärandemål :

circuits in the brain e.g. in cortex, hippocampus and striatum. Describe the principles for excitatory and inhibitory networks, includingreceptors and neurotransmittors. Describe principles for the generation of brain oscillation and synchronization of neuronal activity. Describe the principles, use and readout of optogenetics, including the different opsins. Describe the principles of transsynaptic viraltracing of neuronal circuits. Explain how dysfunctions of networks can manifest as neuropsychiatric disorders. Describe animalbehavior tests probing specific networks and network functions.

The course will cover the organization and function of the main networks in the brain, including the participatingKursens innehåll : cell types, the interplay between excitation and inhibition and network output such as brain oscillations. Different techniques forlabeling and manipulation of neuronal networks will be discussed, including molecular targeting, in vivo optogentics andtranssynaptic viral tracing. The connection between deficient network functions and neuropsychiatric disorders such asschizophrenia, and autism will be covered, as well as animal behavioral test probing specific circuits and circuit (dys)functions.

Lectures by invited experts, group seminars, seminar presentations, written exam.Arbetsformer : The student should demonstrate their knowledge about the items stated above in a written exam. The studentExamination :

should demonstrate that they can critically evaluate original research papers on these topics in a seminar presentation and indiscussions.

The seminar presentations and the written exam are obligatory. Student who cannot attend will be givenObligatoriska moment : the opportunity to perform an individual seminar presentation and take part in an individual exam.

8 - 14Antal studenter : We welcome applicants from all areas of neuroscience with an interest in structural and functional brainUrval av studenter :

networks and their role in behaviors, emotions, psychiatric or mood disorders, and addiction. Selection will be based on therelevance of the course for the student´s research project.

This course is part of the Series of FRONTIERS IN NEUROSCIENCE COURSESYtterligare information :

Kursansvarig : Marie CarlenInstitutionen för [email protected]

Kontaktpersoner : -

Title : Research course on individualized drug dosage in clinical practice and indrug development-application of clinical pharmacokinetic/pharmacodynamicconcepts




Särskild behörighet : At the end of the course the student should be able to -understand and show insights in the need toKursens lärandemål :

individualize drug dosage in clinical practice and during drug development based on genetic, environmental, physiological andconcomitant drug therapy factors -understand the needs for individualizing dosage regimens of drugs in clinical practice and inclinical drug development and the possibilities to design such regimens by using pharmacokinetic/dynamic theories and concepts -design pharmacokinetic/-dynamic studies including sampling schedules for evaluation of drug concentrations and pharmacologicaland outcome effects to establish individualized dosage regimens to treat for example children, elderly and those with decreased liveror kidney functions or patients with infectious or cardiovascular diseases -design individualized dosage regimens by practisingmodelling softwares to evaluate pharmacokinetc/dynamic parameters -show insights in the principles for populationpharmacokinetic/-dynamic modelling using sparse data sampling strategies to individualize dosage regimens -be able to criticallyread, present and discuss scientific papers on indvidualizing dosage regimens -be able to present and discuss own and othersresearch projects related to clinical drug research or clinical drug development -show documented knowledge on the needs forindividualized dosage regimens and demonstrate knowledge on the principles of pharmacokinetics/dynamics to address theseneeds.

BASIC LECTURES ON VARAIBILITY IN DRUG RESPONSE Genetic, environmental, age, drug-drug interactionKursens innehåll : and disease factors are reviewed and discussed focusing on clinical practice and clinical drug development. The focus will be ondifferent pharmacotherapeutic areas and clinical situations including treatment of infectious diseases, using established and newanticoagulant drugs and achieving optimal efficacy and safety when treating children, elderly and patients with decreased kidney orliver functions. TOOLS TO OPTIMIZE DRUG DOSAGE The principles of therapeutic drug monitoring, drug information and ofpharmacokinetics/dynamics tools are reviewed, discussed and used. LITERATURE STUDIES ON RATIONALE FOR CURRENTDOSING REGIMENS OF SELECTED GROUPS AND PHARMACOTHERAPEUTIC AREAS To summarize and discuss Studiesperformed to support dosing principles, Quality of studies, Available data in subgroups (males, females, children, impaired renal orhepatic function), Suggestions for supplementary studies LITERATURE STUDIES ON INDIVIDUALIZING DOSING REGIMENSAND USING PHARMACOKINETIC/DYNAMIC TOOLS Read, summarize, discuss and apply INDIVIDUALIZING DOSINGREGIMENS BY USING PHARMACOKINETIC CONCEPTS Purpose of modelling, pharmacokinetic variables and their physiologicalcorrelates, model selection, compartmental vs. non-compartmental methods, population models, assessment of model performanceINVIDIDUALIZED DOSING REGIMENS BY INTEGRATION OF PHARMACOKINETIC/DYNHAMI CONCEPTS Purpose ofmodelling, pharmacodynamic variables and their physiological correlates, model selection, time dimension in models, assessment ofmodel performance BIOSTATISTICAL TOOLS AND MATHEMATICAL CONCEPTS Graphical presentation of data, types of data(dichotomous, categorical, continuous), logarithms and exponential functions, regression functions (linear, nonlinear, logistic),distribution fitting, parametric and nonparametric statistical tests HANDS-ON TRAINING IN USING SOFTWARES TO DEVELOPINDIVIDUALIZED DOSING REGIMENS Organizing the database, Graphical and statistical methods to explore data, transformationof data setting up aims of modeling, model selection, evaluation of model performance (Confidence intervals for parameters,correlations, AIC), statistical evaluation of results. The focus will be to use Win-Nonlin requiring access to own portable computer.CLINICAL DRUG DEVELOPMENT AND DOSAGE REGIMENS Clinical drug development to optimize dosage regimens arereviewed, discussed and applied including the procedures for registration. The focus will be on a study case of a new drug in thearea of HIV/AIDS. PRESENTATION OF OWN PROJECTS Each course participant will shortly present and discuss own research ordevelopment project related to cliical drug research and optimizing dosage regimens in clinical practice or for development of newdrugs.

Lectures, group work, PK-PD calculations, demonstrations and literature review/seminars. Except forArbetsformer : teachers/lecturers the course will have tutors with about 5 students each.

Literature reviews and home examinationExamination : Lectures, groups work, calculations, demonstrations and seminars are obligatory. If a student fail toObligatoriska moment :

participate in all moments it is required that the students document knowledge/understanding and document that he/she hascalculated and analyzed data. The course includes 2 weeks of full-time participation following lectures, reviewing and presentingresearch articles, participating in work-shops, doing practical exercises including using softwares for calculatingpharmacokinetic/dynamic parameters to improve drog dosage regimens and finally presenting own research projects. One courseweek is for preparatory work and for a home-examination of the course contents.

10 - 25Antal studenter : Prioirity for PhD students in most relevant areas for the course. Urval av studenter :

Observe that the course is for THREE weeks. ONE week totally is used for preparation before the courseYtterligare information : and for HOME EXAMINATION AFTER THE COURSE! Two weeks (121105-121116) require PHYSICAL presence at KarolinskaInstitutet, Clinical Pharmacology, Department of Laboratory Medicine at Karolinska University Hospital Huddinge. The courseleaders are: A. MD PhD Markus Jerling, clinical pharmacologist/psychiatrist, with years of experience in clinical pharmacology andin clinical drug development in Sweden, Europe and US and previous course leader for the joint pharmacokinetic/dynamic researchcourse in Kampala in October 2011. Professor Lars L Gustafsson, clinical pharmacologist, at Karolinska Institutet with years of

experience in understanding variability in drug response focusing on infectious diseases- in particular malaria and HIV/AIDS. MDPhD Staffan Rosenborg, clinical pharmacologist and specialist in renal medicine, and senior staff at Clinical Pharmacology,Karolinska University Hospital. Interested in pharmacogenetic variablity in drug response and adjusted dosage in patients withdecreased kidney function. B. Senior and junior staff at clinical departments at Karolinska University Hospital, specialists fromMedical Products Agents and from drug industries will participate as lecturers or instructors. Associate professor Urban Hellgren atKarolinska University Hospital and Dr Per-Olof Kjellström from Karolinska University Hospital/Medical Products Agency. Prior to thecourse it is recommended to aquire basic knowledge on variability in drug response and aspects on pharmacokinetics andpharmacodynamics. Costs for travel and housing have to be covered by participant/participating home institution. The courseshould BE OF INTEREST for all reserch students involved in clinical and basic drug research. The clinical topics of the course willbe adapted to the background of the students ensuring that the students can contribute with their background and knowledge in howto best understand the needs for individualized dosing regimens. The course will be higly interactive requiring access to ownportable computer to be used for exercises and analyzing data using pharmacokinetic/dynamic software to be available during thecourse period- most likely Winnonlin program. The course particpants are expected to present their own research and therebygetting feed-back irrespective the phase of the studies.

Kursansvarig : Lars-L GustafssonInstitutionen för laboratoriemedicin

[email protected]

Kontaktpersoner : -

Title : Perinatologi




Särskild behörighet : Det övergripande målet är att studenten ska fördjupa sina kunskaper och kunna resonera kring barnetsKursens lärandemål :

fysiologi och klinik. Studenten skall även bygga upp basal kunskap om olika sjukdomstillstånd under nyföddhetstiden. Kunskapernasom specificeras i de nedanstående läromålen är klassificerade enligt SOLO-taxonomin. Mer specifikt skall studenten kunna:Redovisa och resonera kring normal embryogenes och fosterutveckling, särskilt omställningarna vid födelsen och perioden närmastefter (S3). Diagnostiskt analysera och diskutera viktiga akuta sjukdomstillstånd hos foster och nyfödda och, där det är relevant,koppla samman dem med förhållanden under graviditet, födelse och nyföddhet, inklusive arv (S4). Relatera perinatal utveckling tillriskfaktorer hos foster och för tidigt födda som moderns hälsa samt barnets gestationsålder, omgivning och genus (S3). Utifrånepidemologiska data resonera kring sambandet mellan moderns hälsotillstånd och viktiga akuta sjukdomar hos foster och nyföddabarn (S3). Känna till och kunna redogöra för möjligheter och svårigheter inom diagnostik (S2). Beskriva antenatalvård samt vård av-för tidigt födda barn (neonatalvård) (S2). Identifiera begreppet epigenetik (S1), och relatera detta till perinatal programmering som engrund för framtida hälsa och sjukdom (S3).

Kursen behandlar det nära samarbetet mellan obstetrik och neonatologi som vi brukar benämna perinatologi.Kursens innehåll : Livet innan födelsen har långtgående konsekvenser för individens framtida hälsa och utveckling. Vår kunskap om denna väsentligadel av vårt liv ökar snabbt. Vi vet nu att den har en avgörande betydelse för individens framtida liv, liksom att graviditet hos modernär väsentlig för hennes framtida hälsa. Födelsen är en kritisk händelse då den nyfödde snabbt måste ställa om till ett liv utanförlivmodern. Många förändringar sker momentant, såsom påbörjande av andningen, medan andra gradvis utvecklas under den förstatiden postnatalt. Kunskap om dessa är en förutsättning för att förstå de sjukdomstillstånd som kan drabba det nyfödda barnet, menockså för att förstå utvecklingen och fysiologin hos äldre barn och vuxna. Detta är en del av det snabbt växande konceptet perinatalprogrammering och epigenetik, vilket också är en central del av kursens budskap. Betydelsen av miljö och arv diskuteras medsärskilt hänseende till framtida hälsa och sjukdom. Under kursen ska studenten skaffa sig goda kunskaper om fostrets och barnetsfysiologi och klinik, och basal kunskap om olika sjukdomstillstånd som drabbar foster respektive barn under nyföddhetstiden. Kursenberör därför basal embryologi, tillämpad fosterdiagnostik, mödra-, foster- och det nyfödda barnets fysiologi. Vidare avvikelser i dessaskeenden och eventuella interventioner. Identifikation av riskgraviditeter inom mödravård diskuteras. Kursen tar också upp prenatalprogrammering av framtida hälsa, barnets nervsystem och neuropsykomotoriska neuronala utveckling, barnet och medvetandetsamt smärtfysiologi hos den nyfödde, omställningen vid födelsen, centrala andningsstörningar hos den nyfödde och plötsligspädbarnsdöd. Speciellt kommer den sofistikerade interaktionen mellan moder och barn att belysas. Tidiga könsskillnader mellangossar och flickor diskuteras. Kursen kombinerar grundläggande preklinisk medicin med föreläsningar om klinisk praxis. Det ärkursens ambition att även kombinera etablerad medicinsk kunskap med senaste forskningsrön inom detta snabbt förändrandeområde. Kursen är indelad i olika delar som omfattar: Här startar allt: Befruktning, implantation, embryologi. Fosterfysiologi: nyfödd(hjärta-cirkulation, njurar, lungor-andning). Neonatal fysiologi vid födelsen och under nyföddhetsperioden. Fysiologisk interaktionmamma - foster - nyfödd. Epigenetiska mekanismer, Barker hypotesen, betydelsen av intrauterin och postnatal miljö för framtidahälsa för barnet.

Föreläsningar, fallbeskrivningar och seminarier. Studenten kommer att arbeta med integrerade frågeställningarArbetsformer : såsom enkla studier av fetal fysiologi. När är fostret vaket? Hur varseblir modern fostret? Varför startat de flesta förlossningarna pånatten? När utvecklas fostret- det nyfödda barnet sina sinnen? Pappans roll vid graviditetsavvikelser. Det första året efterfödelsen-vad händer? Under kursen skall varje deltagare göra ett individuellt arbete skriftligt redovisat på svenska eller engelskamed referenser till den vetenskapliga litteraturen (c:a 8 sidor med enkelt radavstånd). Det skrivna skall behandla något ämne, somrelaterar till kursens huvudtema. En handledare ska finnas tillgänglig för en stödjande diskussion en gång i veckan och godkännerslutligen det skrivna arbetet. Detta redovisas muntligt vid ett seminarium med hela kursen.

Examination: För godkänd kurs krävs: a) Aktivt deltagande i seminarie verksamheten. Kontinuerlig feedback ges iExamination : samband med seminarie presentationer och diskussioner. b) Skriftligt samt muntlig redovisning av individuellt fördjupningsarbete. c)Kursen avslutas med skriftlig examen där minst 2/3 rätt svar på kortsvarsfrågor krävs för godkänd kurs.

Aktivt deltagande i seminarieverksamheten. Mer än 3 dagars frånvaro från den kontinuerligaObligatoriska moment : seminarieverksamheten får kompenseras i samråd med kursledningen.

1 - 10Antal studenter : Sökanden skriver kort (1/2 A4, enkelt radavstånd) om sin bakgrund och motivation för att gå kursen. UtifrånUrval av studenter :

detta görs urval.OBS, KURSEN PÅGÅR FRAM TILL 18 JANUARI. Kursen ges som föreläsningar och seminarier varjeYtterligare information :

dag (halvdag), med undantag för juluppehållet. Föreläsningarna är gemensamma med kursen SVK Perinatologi på läkarlinjenstermin 5.

Kursansvarig : Eric HerleniusEj satt

[email protected]

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Title : Neurodegenerative disorders I - From molecule to treatment




Särskild behörighet : The student should: Understand the cellular processes and molecular mechanisms of neurodegeneration.Kursens lärandemål :

Understand mechanisms of protein turnover and degradation, and protein aggregation, and from these mechanisms criticallyevaluate the concept of conformational disorders, and its relevance to the different neurodegenerative disorders. Have achievedbasic knowledge about epidemiology, symptoms, pathology and current treatments of the most common neurodegenerativedisorders such as stroke, Alzheimer¿s disease, frontotemporal dementia, Lewy body disease, Parkinson¿s disease, multiplesclerosis, amyotrophic lateral sclerosis, ataxias, prion diseases, epilepsy and trauma. Understand how the pathology of thesedisorders is reflected in their symptoms. Based on this understanding, be able to discuss the effects of treatments, if they are (ormay be) symptomatic or curative. Be able to evaluate the relevance of different disease models, their advantages and limitationswith respect to the clinical picture and to what is known about disease mechanisms.

The course will cover topics related to the degeneration of neurons, apoptosis and necrosis, and the cellular andKursens innehåll : biochemical reactions to neuronal injury. The teachers will also present and discuss symptoms, diagnosis, pathology, epidemiology,genetics and treatment of neurodegenerative disorders such as stroke, Alzheimer's disease, frontotemporal dementia, Lewy bodydisease, Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis, ataxias, prion diseases, epilepsy and trauma.Molecular mechanisms of current and future treatment strategies, disease models and their potential, will be presented anddiscussed.

The course runs daytime for 1 week full-time with lectures by invited scientists, literature seminars as groupArbetsformer : assignments, and individual studies.

Written examination followed by group discussions on the examination questions, and a general discussion betweenExamination : all participants.

Literature seminars and the exam (including the group discussion after the exam) are compulsory.Obligatoriska moment : Students that are absent from literature seminars will have to submit a written presentation of the subject.

10 - 30Antal studenter : In case too many students apply, selection of participants will be based on how relevant the course content isUrval av studenter :

to the student's study planThis course is part of the Series of FRONTIERS IN NEUROSCIENCE COURSES. The course is given atYtterligare information :

Novum, Huddinge.

Kursansvarig : Erik SundströmInstitutionen för neurobiologi, vårdvetenskap och samhä[email protected]

Kontaktpersoner : -

Title : Neurodegenerativa sjukdomar II - cellulära och molekylära mekanismer




Särskild behörighet : The student should: Understand and critically evaluate relevant cellular and molecular pathophysiologicalKursens lärandemål :

mechanisms of neurodegenerative disorders such as stroke, Alzheimer¿s disease, frontotemporal dementia, Lewy body disease,Parkinson¿s disease, multiple sclerosis, amyotrophic lateral sclerosis, ataxias, prion diseases, epilepsy and trauma, and themechanisms of current and/or possible future treatments. Understand and be able to perform the common assays of celldegeneration, and discuss the results, taking into account the limitations of the assays. Be able to discuss the present diseasemodels, propose alternative models, and critically evaluate these models from the perspectives of a) clinical picture, b) diseasemechanisms, and c) treatment mechanisms

The course is a continuation of the course Neurodegenerative disorders ¿ From molecule to treatment, but itKursens innehåll : can also be taken as a separate course, provided the participant has in other ways achieved the learning outcomes of that course. The course addresses topics in basic and clinical research on neurodegenerative disorders, with a particular focus on the cellularand molecular mechanisms. The focus will be on a deeper understanding of cellular and molecular mechanisms, and the techniquesto study them.

The course runs daytime for 1 week full-time with some key lectures by invited scientists, laboratory practicals,Arbetsformer : literature seminars, and discussions in small groups and the entire class.

Written examination followed by group discussions on the examination questions, and a general discussion betweenExamination : all participants.

Laboratory practicals, literature seminars and the exam (including the group discussion after the exam) areObligatoriska moment : compulsory. Students that are absent from literature seminars and/or practicals will have to submit a written presentation of thesubject.

10 - 24Antal studenter : In case the number of applicants is too large, we will select participants based on two criteria (in order ofUrval av studenter :

priority): 1: Relevance of the course content to the student's study plan 2: Urgency of receiving course credits for planned thesisdefense

The course will take place at Novum, Huddinge. For the lab-practicals we will be at the Geriatric ClinicYtterligare information : Research Lab, Novum 5th floor.

Kursansvarig : Erik SundströmInstitutionen för neurobiologi, vårdvetenskap och samhä[email protected]

Kontaktpersoner : -

Title : Grundläggande biostatistik




Särskild behörighet : Studenten skall efter slutförande av kursen kunna beräkna enkla statistiska mått (medelvärde, median,Kursens lärandemål :

standardavvikelse, etc), skapa diagram (histogram, lådagram, stapeldiagram, cirkeldiagram, etc), utföra parametriska och icke -parametriska tvågruppsanalyser (t-test, Chi2 test, Wilcoxon test, etc), samt utföra styrke - och stickprovsberäkningar. Dessutomkommer kursdeltagarna att få en introduktion till mer avancerade statistiska metoder i form av en kort översikt av linjär regressionoch variansanalys. Efter slutförande av kursen förväntas kursdeltagaren, att med hjälp av kursmaterialet, kunna avgöra vilken/vilkaanalysmetoder som är lämpliga att använda i det egna forskningsprojektet, samt att kunna utföra statistiska analyser med hjälp avprogramvaran STATA 10. Kursdeltagaren skall även kunna avgöra när mer avancerade statistiska metoder behöver användas ochom ett samarbete med en statistiker i så fall behöver inledas.

Introduktion till biostatistik Deskriptiv statistik Hypotesprövning (parametriska metoder) Hypotesprövning (Icke -Kursens innehåll : parametriska metoder) Konfidens intervall, styrkeberäkningar, och stickprovsstorleksberäkningar Introduktion till regressionsanalysoch variansanalys

Föreläsningar med genomgång av teoretiska definitioner och statistiska antaganden, samt med tillämpandeArbetsformer : exempel från det medicinska och epidemilogiska området på förmiddagar. Sammanfattning av föreläsningar och praktiska övningar(under handledning) med STATA 10.0 på eftermiddagar. Deltagaren behöver inte ha förkunskaper i programmet STATA, vi delar utalla nödvändiga instruktioner i from av ett kurskompendium, samt har en grundläggande genomgång av programmet. Vid varjeövningsfråga anges vilket STATA kommando som kan användas. Granskning och diskussion av vetenskapliga artiklar iseminarieform och som hemuppgift.

Kursavsnitten examineras genom individuella datorlaborationer och skriftliga svar på teoretiska frågor som lämnas inExamination : varje dag. Skriftlig uppgift vid händelse av frånvaro på obligatoriska moment, inom 3 veckor efter att kursen avslutats.

Krav: Obligatorisk närvaro vid alla föreläsningar på förmiddagar och introduktion till datorlaborationer påObligatoriska moment : eftermiddagar. Frånvaro kompenseras genom extra. inlämningsuppgift avseende den del av kursen som frånvaron gäller.

35 - 40Antal studenter : Sökande prioriteras utifrån motivering och relevans för forskarplanen. Urval av studenter :

Förkunskaper i programvara STATA eller SAS, SPSS, STATISTICA är önskevärt. Kursdeltagarna bedömsYtterligare information : individuellt. Studenterna tillåts att samarbeta under datorlaborationer men på examinationsmoment skall det tydligt framgå att varjeindivid har uppnått tillräcklig kunskap för att självständigt kunna analysera och tolka liknande problem i sina egna forskningsprojekt. -Underkänd: Ej svar på hela frågan, felaktigt svar, osammanhängande resonemang, irrelevanta faktorer som visar på bristandeförståelse. - Godkänd: Korrekt och relevant svar, besvarat hela frågan, korrekta och relevanta fakta, utförligt resonemang kringorsak och verkan.

Kursansvarig : Farhad AlinaghizadehInstitutionen för neurobiologi, vårdvetenskap och samhä[email protected]

Alfred Nobels allé 12

141 83Huddinge

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Katalog kurser på forskarnivå HT12 - KIkiwas.ki.se/kicoursecatalogueHT12.pdf · Katalog kurser på forskarniv